[ { "uniprot_canonical_ac": "P83860-1", "uniprot_id": [ { "id": "OX26_RAT", "url": "https://www.uniprot.org/uniprot/P83860", "type": "external" } ], "mass": 13653.0, "length": 124, "protein_name": "Orexigenic neuropeptide QRFP", "gene_name": "Qrfp", "organism": "Rat", "refseq_name": "orexigenic neuropeptide QRFP precursor", "refseq_ac": [ { "id": "NP_937843", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_937843", "type": "external" } ], "gene_names_uniprotkb": "Qrfp; P518", "gene_names_refseq": "26RFa; NEWGENE_735020; P518; Qrfp", "protein_names_uniprotkb": "Orexigenic neuropeptide QRFP; Neuropeptide RF-amide; P518; Pyroglutamylated arginine-phenylalanine-amide peptide", "protein_names_refseq": "P518 precursor protein; orexigenic neuropeptide QRFP precursor; orexigenic neuropeptide QRFP", "tax_id": 10116, "disease": "", "pathway": " (rno:379044); (R-RNO-389397); (R-RNO-416476)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "12960173;14657341;15891009;16543265;16648250;19341706;19520126;21473894;23979792;26823127", "class_list": "", "function": "Data suggest that the GPR103-26RFa system modulates nociceptive transmission in both the spinal cord and the supraspinal brain in the formalin (paw) test., [RefSeq, PubMed]; Potential role of the orexigenic peptide 26RFa in the control of the gonadotropic axis, thus suggesting its potential involvement in the joint control of energy balance and reproduction, especially in the female, [RefSeq, PubMed]; Prepro-26RFa mRNA is expressed exclusively in two hypothalamic nuclei involved in the control of feeding behavior., [RefSeq, PubMed]; QRFP 43 might play a role downstream of leptin in the regulation of feeding behavior., [RefSeq, PubMed]; QRFP mRNA was highly expressed in the hypothalamus; QRFP receptor mRNA was highly expressed in the adrenal gland. Data suggests that QRFP and its receptor have a regulatory function in the rat adrenal gland., [RefSeq, PubMed]; QRFP may play a role in coordinating feeding behaviors with reproductive function in rats when energy demand is increased., [RefSeq, PubMed]; Stimulates feeding and grooming behavior, metabolic rate and locomotor activity and increases blood pressure. May have orexigenic activity. May promote aldosterone secretion by the adrenal gland., [UniProtKB, PubMed]; Studies support a role for estradiol (E2) in the regulation of prepro-QRFP mRNA in the ventral medial nucleus of the hypothalamus/arcuate nucleus and suggest that E2's effects on food intake may be via a direct effect on the orexigenic peptide, QRFP., [RefSeq, PubMed]; The present review discusses the role of QRFP in the regulation of feeding behavior, with emphasis on the intake of dietary fat., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001664 G protein-coupled receptor binding;GO:0005184 neuropeptide hormone activity;GO:0031854 orexigenic neuropeptide QRFP receptor binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0007626 locomotory behavior;GO:0045777 positive regulation of blood pressure;GO:0060259 regulation of feeding behavior;GO:0007625 grooming behavior", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P83860-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q04931-1", "uniprot_id": [ { "id": "SSRP1_RAT", "url": "https://www.uniprot.org/uniprot/Q04931", "type": "external" } ], "mass": 80914.0, "length": 709, "protein_name": "FACT complex subunit SSRP1", "gene_name": "Ssrp1", "organism": "Rat", "refseq_name": "FACT complex subunit SSRP1", "refseq_ac": [ { "id": "NP_112383", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112383", "type": "external" } ], "gene_names_uniprotkb": "Ssrp1; Ciidbp", "gene_names_refseq": "Ssrp1", "protein_names_uniprotkb": "FACT complex subunit SSRP1; Facilitates chromatin transcription complex subunit SSRP1; Recombination signal sequence recognition protein 1; Structure-specific recognition protein 1; T160", "protein_names_refseq": "FACT complex subunit SSRP1; T160; facilitates chromatin transcription complex subunit SSRP1; recombination signal sequence recognition protein 1", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (rno:81785); (R-RNO-112382); (R-RNO-674695); (R-RNO-6796648); (R-RNO-6804756); (R-RNO-75955); (R-RNO-9943411)", "pathway_count": 7, "publication_count": 3, "publication_id_list": "10336466;22673903;8464746", "class_list": "", "function": "Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5XIT2", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0042393 histone binding;GO:0031491 nucleosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0035101 FACT complex;GO:0005694 chromosome", "go_biological_process": "GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0006260 DNA replication;GO:0006337 nucleosome disassembly;GO:1902275 regulation of chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q04931-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q498D5-1", "uniprot_id": [ { "id": "RMD2_RAT", "url": "https://www.uniprot.org/uniprot/Q498D5", "type": "external" } ], "mass": 47217.0, "length": 412, "protein_name": "Regulator of microtubule dynamics protein 2", "gene_name": "Rmdn2", "organism": "Rat", "refseq_name": "regulator of microtubule dynamics protein 2", "refseq_ac": [ { "id": "NP_001032277", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032277", "type": "external" } ], "gene_names_uniprotkb": "Rmdn2; Fam82a1; Fam82a", "gene_names_refseq": "Fam82a1; Fam82a; Rmdn2", "protein_names_uniprotkb": "Regulator of microtubule dynamics protein 2; Protein FAM82A1; RMD-2", "protein_names_refseq": "RMD-2; family with sequence similarity 82, member A1; family with sequence similarity 82, member A; regulator of microtubule dynamics protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:313840)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22673903;29393594;37153858", "class_list": "", "function": "Regulation of Hepatocytes in G0 and G1 Phases by NOTCH3 mRNA, miR-369-3p, and rno-Rmdn2_0006 during the Initial Stage of Rat Liver Regeneration. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0016020 membrane;GO:0005876 spindle microtubule", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q498D5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KLL5-1", "uniprot_id": [ { "id": "ROP1_RAT", "url": "https://www.uniprot.org/uniprot/Q4KLL5", "type": "external" } ], "mass": 23961.0, "length": 212, "protein_name": "Ropporin-1", "gene_name": "Ropn1", "organism": "Rat", "refseq_name": "ropporin-1", "refseq_ac": [ { "id": "NP_001020799", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020799", "type": "external" } ], "gene_names_uniprotkb": "Ropn1", "gene_names_refseq": "Ropn1", "protein_names_uniprotkb": "Ropporin-1; Rhophilin-associated protein 1", "protein_names_refseq": "rhophilin-associated protein 1; ropporin, rhophilin associated protein 1; ropporin-1", "tax_id": 10116, "disease": "", "pathway": " (rno:288053)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0097598 sperm cytoplasmic droplet;GO:0005737 cytoplasm;GO:0031514 motile cilium;GO:0097228 sperm principal piece", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0048240 sperm capacitation;GO:0001932 regulation of protein phosphorylation;GO:0061512 protein localization to cilium;GO:0044782 cilium organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4KLL5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BJQ5-1", "uniprot_id": [ { "id": "RIT2_RAT", "url": "https://www.uniprot.org/uniprot/Q5BJQ5", "type": "external" } ], "mass": 24761.0, "length": 217, "protein_name": "GTP-binding protein Rit2", "gene_name": "Rit2", "organism": "Rat", "refseq_name": "GTP-binding protein Rit2", "refseq_ac": [ { "id": "NP_001013078", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013078", "type": "external" } ], "gene_names_uniprotkb": "Rit2", "gene_names_refseq": "Rin; Rit1; Rit2", "protein_names_uniprotkb": "GTP-binding protein Rit2; 3.6.5.2", "protein_names_refseq": "GTP-binding protein Rit2; Ras-like without CAAX 1", "tax_id": 10116, "disease": "acute myocardial infarction (Disease Ontology:DOID:9408)", "pathway": " (rno:291713)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16157584;17460085;18541665", "class_list": "", "function": "Binds and exchanges GTP and GDP., [UniProtKB]; Observations establish Rin as a neuronal specific regulator of neurotrophin signaling, required to couple NGF stimulation to sustain activation of p38 MAP kinase and b-Raf signaling cascades required for neuronal development [rin], [RefSeq, PubMed]; Rit is a convergence point for multiple signaling pathways and it functions to promote axonal growth but inhibit dendritic growth via activation of ERK1/2, [RefSeq, PubMed]; These observations identify an unsuspected role for Rin in neuronal PACAP signaling and establish a novel Galpha-Src-Rin-HSP27 signal transduction pathway as a critical element in PACAP38-mediated neuronal differentiation signaling., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003924 GTPase activity;GO:0005516 calmodulin binding;GO:0005525 GTP binding;GO:0030215 semaphorin receptor binding", "go_cellular_component": "GO:0097447 dendritic tree;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0032507 maintenance of protein location in cell;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0010976 positive regulation of neuron projection development;GO:0030100 regulation of endocytosis;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5BJQ5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62991-1", "uniprot_id": [ { "id": "SCFD1_RAT", "url": "https://www.uniprot.org/uniprot/Q62991", "type": "external" } ], "mass": 72263.0, "length": 637, "protein_name": "Sec1 family domain-containing protein 1", "gene_name": "Scfd1", "organism": "Rat", "refseq_name": "sec1 family domain-containing protein 1", "refseq_ac": [ { "id": "NP_062237", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062237", "type": "external" } ], "gene_names_uniprotkb": "Scfd1; Ra410; Sly1; Stxbp1l2", "gene_names_refseq": "RA410; Scfd1; Sly1; rSly1", "protein_names_uniprotkb": "Sec1 family domain-containing protein 1; SLY1 homolog; Sly1p; Syntaxin-binding protein 1-like 2; Vesicle transport-related protein Ra410", "protein_names_refseq": "SLY1 homolog; sec1 family domain-containing protein 1; sly1p; syntaxin-binding protein 1-like 2; vesicle transport-related protein Ra410", "tax_id": 10116, "disease": "", "pathway": " (rno:54350); (R-RNO-204005); (R-RNO-8980692)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10930465;15649705;15670607;19536132;22673903;8647468;8663406;9195952", "class_list": "", "function": "Elucidated the structure in solution of the isolated N-terminal domain of rat Sly1 and analyzed its complex with an N-terminal peptide of rat syntaxin 5 by NMR spectroscopy, [RefSeq, PubMed]; Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These results suggest that RA410/Sly1 plays an important cytoprotective role in MPP+ and 6-OHDA-induced cellular perturbation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q62843", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0019905 syntaxin binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005798 Golgi-associated vesicle;GO:0005789 endoplasmic reticulum membrane;GO:0032580 Golgi cisterna membrane;GO:0005801 cis-Golgi network", "go_biological_process": "GO:1902902 negative regulation of autophagosome assembly;GO:0051223 regulation of protein transport;GO:0060628 regulation of ER to Golgi vesicle-mediated transport;GO:0006886 intracellular protein transport;GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q62991-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63635-1", "uniprot_id": [ { "id": "STX6_RAT", "url": "https://www.uniprot.org/uniprot/Q63635", "type": "external" } ], "mass": 29057.0, "length": 255, "protein_name": "Syntaxin-6", "gene_name": "Stx6", "organism": "Rat", "refseq_name": "syntaxin-6", "refseq_ac": [ { "id": "NP_113853", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113853", "type": "external" } ], "gene_names_uniprotkb": "Stx6", "gene_names_refseq": "Stx6", "protein_names_uniprotkb": "Syntaxin-6", "protein_names_refseq": "Syn6; syntaxin-6", "tax_id": 10116, "disease": "", "pathway": " (rno:60562); (R-RNO-6811438); (R-RNO-6811440)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10506127;12082176;15689499;16428329;20163565;22673903;30962439;8663448", "class_list": "", "function": "SNARE promoting movement of transport vesicles to target membranes (PubMed:30962439). Targets endosomes to the trans-Golgi network, and may therefore function in retrograde trafficking (PubMed:30962439). Together with SNARE STX12, promotes movement of vesicles from endosomes to the cell membrane, and may therefore function in the endocytic recycling pathway (PubMed:30962439)., [UniProtKB, PubMed]; SNARE promoting movement of transport vesicles to target membranes. Targets endosomes to the trans-Golgi network, and may therefore function in retrograde trafficking. Together with SNARE STX12, promotes movement of vesicles from endosomes to the cell membrane, and may therefore function in the endocytic recycling pathway., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019905 syntaxin binding;GO:0000149 SNARE binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0032880 regulation of protein localization;GO:0007032 endosome organization;GO:0016192 vesicle-mediated transport;GO:0042147 retrograde transport, endosome to Golgi", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q63635-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68FY0-1", "uniprot_id": [ { "id": "QCR1_RAT", "url": "https://www.uniprot.org/uniprot/Q68FY0", "type": "external" } ], "mass": 52849.0, "length": 480, "protein_name": "Cytochrome b-c1 complex subunit 1, mitochondrial", "gene_name": "Uqcrc1", "organism": "Rat", "refseq_name": "cytochrome b-c1 complex subunit 1, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001004250", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004250", "type": "external" } ], "gene_names_uniprotkb": "Uqcrc1", "gene_names_refseq": "Uqcrc1", "protein_names_uniprotkb": "Cytochrome b-c1 complex subunit 1, mitochondrial; Complex III subunit 1; Core protein I; Ubiquinol-cytochrome-c reductase complex core protein 1", "protein_names_refseq": "complex III subunit 1; core protein I; cytochrome b-c1 complex subunit 1, mitochondrial precursor; cytochrome b-c1 complex subunit 1, mitochondrial; ubiquinol-cytochrome c reductase core protein I; ubiquinol-cytochrome-c reductase complex core protein 1", "tax_id": 10116, "disease": "multiple mitochondrial dysfunctions syndrome 6 (Disease Ontology:DOID:0070332); Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (rno:301011); (R-RNO-611105); (R-RNO-9865881)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "18047804;18683930;19004814;22673903;26446791;27213235;28676853;28750029;32819597;34502162", "class_list": "", "function": "Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (By similarity). The 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2 are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively, and they seem to have preserved their MPP processing properties. May be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS)/subunit 9 when incorporated into complex III (By similarity). Seems to play an important role in the maintenance of proper mitochondrial function in nigral dopaminergic neurons (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The overexpression of UQCRC1 can protect H9c2 cardiac cells against simulated ischemia/reperfusion, and this cardio-protective effect is likely mediated by zinc binding., [RefSeq, PubMed]; These results showed that UQCRC1 might contribute to the loss-of-cardioprotection model induced by long-term diazoxide treatment and play a role in delayed cardioprotection. Publication Status: Online-Only, [RefSeq, PubMed]; Ubiquinol-cytochrome c reductase core protein 1 overexpression protects H9c2 cardiac cells against mimic ischemia/reperfusion injury through PI3K/Akt/GSK-3beta pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0031625 ubiquitin protein ligase binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045275 respiratory chain complex III;GO:0017087 mitochondrial processing peptidase complex", "go_biological_process": "GO:0043279 response to alkaloid;GO:0014823 response to activity;GO:0006627 protein processing involved in protein targeting to mitochondrion;GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q68FY0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXT5-1", "uniprot_id": [ { "id": "RAB21_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXT5", "type": "external" } ], "mass": 24163.0, "length": 223, "protein_name": "Ras-related protein Rab-21", "gene_name": "Rab21", "organism": "Rat", "refseq_name": "ras-related protein Rab-21", "refseq_ac": [ { "id": "NP_001004238", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004238", "type": "external" } ], "gene_names_uniprotkb": "Rab21", "gene_names_refseq": "Rab21", "protein_names_uniprotkb": "Ras-related protein Rab-21; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-21", "tax_id": 10116, "disease": "", "pathway": " (rno:299799); (R-RNO-8873719); (R-RNO-8876198)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "19745841", "class_list": "", "function": "The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB21 is involved in membrane trafficking control (By similarity). Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general (By similarity). As a result, may regulate cell adhesion and migration (By similarity). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis (By similarity). Involved in neurite growth (PubMed:19745841). Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (By similarity). Modulates protein levels of the cargo receptors TMED2 and TMED10, and required for appropriate Golgi localization of TMED10 (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0019003 GDP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005769 early endosome;GO:0045202 synapse;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0050821 protein stabilization;GO:0030516 regulation of axon extension;GO:0008089 anterograde axonal transport;GO:0050775 positive regulation of dendrite morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AXT5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80WD0-1", "uniprot_id": [ { "id": "R4RL1_RAT", "url": "https://www.uniprot.org/uniprot/Q80WD0", "type": "external" } ], "mass": 49775.0, "length": 445, "protein_name": "Reticulon-4 receptor-like 1", "gene_name": "Rtn4rl1", "organism": "Rat", "refseq_name": "reticulon-4 receptor-like 1 precursor", "refseq_ac": [ { "id": "NP_852042", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_852042", "type": "external" } ], "gene_names_uniprotkb": "Rtn4rl1; Ngrh2", "gene_names_refseq": "Ngrh2; Rtn4rl1", "protein_names_uniprotkb": "Reticulon-4 receptor-like 1; NgR3; Nogo receptor-like 2; Nogo-66 receptor homolog 2; Nogo-66 receptor-related protein 3", "protein_names_refseq": "Nogo-66 receptor homolog 2; ngR3; nogo receptor-like 2; nogo-66 receptor-related protein 3; reticulon-4 receptor-like 1 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:303311)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12694398;15673660;19063867;22325200", "class_list": "", "function": "Cell surface receptor. Plays a functionally redundant role in postnatal brain development and in regulating axon regeneration in the adult central nervous system. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG. Plays a role in inhibiting neurite outgrowth and axon regeneration via its binding to neuronal chondroitin sulfate proteoglycans. Binds heparin (By similarity). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200)., [UniProtKB, PubMed, UniProtKB]; Spatio-temporal expression pattern of NgR1, NgR2 & NgR3 mRNAs & corresponding proteins in developing olfactory system; data suggest, in non-pathological conditions, NgR1 & homologs may play a role in axon outgrowth in the olfactory system., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1L1I9;Q7TQ96", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0035374 chondroitin sulfate binding;GO:0048495 Roundabout binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0043204 perikaryon;GO:0045121 membrane raft;GO:0042995 cell projection", "go_biological_process": "GO:0010977 negative regulation of neuron projection development;GO:0050919 negative chemotaxis;GO:0007411 axon guidance;GO:0022038 corpus callosum development;GO:0048681 negative regulation of axon regeneration", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q80WD0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80WD1-1", "uniprot_id": [ { "id": "R4RL2_RAT", "url": "https://www.uniprot.org/uniprot/Q80WD1", "type": "external" } ], "mass": 46184.0, "length": 420, "protein_name": "Reticulon-4 receptor-like 2", "gene_name": "Rtn4rl2", "organism": "Rat", "refseq_name": "reticulon-4 receptor-like 2 precursor", "refseq_ac": [ { "id": "NP_852045", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_852045", "type": "external" } ], "gene_names_uniprotkb": "Rtn4rl2; Ngrh1", "gene_names_refseq": "Ngrh1; Rtn4rl2", "protein_names_uniprotkb": "Reticulon-4 receptor-like 2; NgR2; Nogo receptor-like 3; Nogo-66 receptor homolog 1; Nogo-66 receptor-related protein 2", "protein_names_refseq": "Nogo-66 receptor homolog 1; ngR2; nogo receptor-like 3; nogo-66 receptor-related protein 2; reticulon-4 receptor-like 2 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:311169); (R-RNO-163125)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "12658441;12694398;15673660;18056009;19063867;19420245;21308849;22325200;26335717;34544340;34643252;38843836", "class_list": "", "function": "Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG (PubMed:15673660). Plays a functionally redundant role in postnatal brain development. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system (By similarity). Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG (PubMed:26335717). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Crystal structure of the leucine-rich repeat region and part of the stalk regions of NgR2 and comparison to the previously reported NgR1 structure with respect to the distinct signaling properties of the two receptor isoforms, [RefSeq, PubMed]; Downregulation of Nogo receptor(NgR) after kainic acid or wheel-running in cortex and hippocampus suggests a role for NgR and Nogo-A in plasticity, learning and memory., [RefSeq, PubMed]; NEP1-40-overexpressing Neural Stem Cells Enhance Axon Regeneration by Inhibiting Nogo-A/NgR1 Signaling Pathway., [RefSeq, PubMed]; NEP140 promotes myelin regeneration via upregulation of GAP43 and MAP2 expression after focal cerebral ischemia in rats. Erratum:[Mol Med Rep. 2023 Mar;27(3):58. doi: 10.3892/mmr.2023.12945. PMID: 36695184], [RefSeq, PubMed]; Spatio-temporal expression pattern of NgR1, NgR2 & NgR3 mRNAs & corresponding proteins in developing olfactory system; data suggest, in non-pathological conditions, NgR1 & homologs may play a role in axon outgrowth in the olfactory system., [RefSeq, PubMed]; The authors' results indicate that severed rubrospinal axons respond to NEP1-40 treatment but less robustly than corticospinal, raphe-spinal, or dorsal root axons., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030424 axon;GO:0030425 dendrite;GO:0043204 perikaryon", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0010977 negative regulation of neuron projection development;GO:0051965 positive regulation of synapse assembly;GO:0022038 corpus callosum development", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q80WD1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.1100000001000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JI92-1", "uniprot_id": [ { "id": "SDCB1_RAT", "url": "https://www.uniprot.org/uniprot/Q9JI92", "type": "external" } ], "mass": 32423.0, "length": 300, "protein_name": "Syntenin-1", "gene_name": "Sdcbp", "organism": "Rat", "refseq_name": "syntenin-1", "refseq_ac": [ { "id": "NP_114192", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114192", "type": "external" } ], "gene_names_uniprotkb": "Sdcbp", "gene_names_refseq": "Sdcbp; TACIP18; mda-9", "protein_names_uniprotkb": "Syntenin-1; Syndecan-binding protein 1", "protein_names_refseq": "sdc binding protein; syndecan-binding protein 1; syntenin-1; syntenin", "tax_id": 10116, "disease": "", "pathway": " (rno:83841); (R-RNO-3928664); (R-RNO-447043); (R-RNO-5213460); (R-RNO-5675482); (R-RNO-6798695)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "11152476;11179419;11434923;22673903;27830760", "class_list": "", "function": "Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis. Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1. In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis. Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway., [UniProtKB, UniProtKB]; Syntenin-1 negatively regulates syndecan-4 function via oligomerization and/or syndecan-4 interaction, impacting cytoskeletal organization and cell migration. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005109 frizzled binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0019838 growth factor binding;GO:0042802 identical protein binding;GO:0046875 ephrin receptor binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0099054 presynapse assembly;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation;GO:0030307 positive regulation of cell growth;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9JI92-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1Y0-1", "uniprot_id": [ { "id": "RHOV_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z1Y0", "type": "external" } ], "mass": 26165.0, "length": 236, "protein_name": "Rho-related GTP-binding protein RhoV", "gene_name": "Rhov", "organism": "Rat", "refseq_name": "rho-related GTP-binding protein RhoV", "refseq_ac": [ { "id": "NP_612551", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612551", "type": "external" } ], "gene_names_uniprotkb": "Rhov", "gene_names_refseq": "Arhv; Chp; Rhov", "protein_names_uniprotkb": "Rho-related GTP-binding protein RhoV; 3.6.5.2; Rho family GTPase Chp", "protein_names_refseq": "calcium binding protein p22; ras homolog gene family, member V; rho family GTPase Chp; rho-related GTP-binding protein RhoV", "tax_id": 10116, "disease": "", "pathway": " (rno:171581); (R-RNO-9013424)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "15664990;16641371;9778532", "class_list": "", "function": "Plays a role in the control of the actin cytoskeleton via activation of the JNK pathway., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 11, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0H2UHK9", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0007165 signal transduction;GO:0007264 small GTPase-mediated signal transduction;GO:0008360 regulation of cell shape", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9Z1Y0-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99372-1", "uniprot_id": [ { "id": "ELN_RAT", "url": "https://www.uniprot.org/uniprot/Q99372", "type": "external" } ], "mass": 73330.0, "length": 870, "protein_name": "Elastin", "gene_name": "Eln", "organism": "Rat", "refseq_name": "elastin precursor", "refseq_ac": [ { "id": "NP_036854", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036854", "type": "external" } ], "gene_names_uniprotkb": "Eln", "gene_names_refseq": "Eln; RATTREL11; TREL11; Trela26; Trela", "protein_names_uniprotkb": "Elastin; Tropoelastin", "protein_names_refseq": "Tropoelastin; elastin precursor", "tax_id": 10116, "disease": "pterygium (Disease Ontology:DOID:0002116); autosomal dominant cutis laxa 1 (Disease Ontology:DOID:0070130); polymyositis (Disease Ontology:DOID:0080745); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); Buschke-Ollendorff syndrome (Disease Ontology:DOID:0111536); pigmentation disease (Disease Ontology:DOID:10123); silicosis (Disease Ontology:DOID:10325); primary open angle glaucoma (Disease Ontology:DOID:1070); essential hypertension (Disease Ontology:DOID:10825); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); thromboangiitis obliterans (Disease Ontology:DOID:12918); temporal arteritis (Disease Ontology:DOID:13375); exfoliation syndrome (Disease Ontology:DOID:13641); bladder neck obstruction (Disease Ontology:DOID:13948); aortic valve stenosis (Disease Ontology:DOID:1712); melanoma (Disease Ontology:DOID:1909); Williams-Beuren syndrome (Disease Ontology:DOID:1928); supravalvular aortic stenosis (Disease Ontology:DOID:1929); pseudoxanthoma elasticum (Disease Ontology:DOID:2738); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); cutis laxa (Disease Ontology:DOID:3144); photosensitivity disease (Disease Ontology:DOID:3159); aortic aneurysm (Disease Ontology:DOID:3627); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); systemic scleroderma (Disease Ontology:DOID:418); macular degeneration (Disease Ontology:DOID:4448); liver cirrhosis (Disease Ontology:DOID:5082); aortic valve disease (Disease Ontology:DOID:62); rheumatoid arthritis (Disease Ontology:DOID:7148); abdominal aortic aneurysm (Disease Ontology:DOID:7693); dermatitis herpetiformis (Disease Ontology:DOID:8505); psoriasis (Disease Ontology:DOID:8893); diabetic retinopathy (Disease Ontology:DOID:8947); systemic lupus erythematosus (Disease Ontology:DOID:9074); polyarteritis nodosa (Disease Ontology:DOID:9810)", "pathway": " (rno:25043); (R-RNO-1474228); (R-RNO-1566948); (R-RNO-2129379)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "12882762;1572637;1702999;26479776;2768256;2913947;2971041;32630068;32794252;33558588;33761588;38508328", "class_list": "", "function": "Elastin levels are higher in healing tendons than in intact tendons and influence tissue compliance., [RefSeq, PubMed]; Enhancement of elastin expression by transdermal administration of sialidase isozyme Neu2. Publication Status: Online-Only, [RefSeq, PubMed]; LncRNA Xist induces arterial smooth muscle cell apoptosis in thoracic aortic aneurysm through miR-29b-3p/Eln pathway., [RefSeq, PubMed]; Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity)., [UniProtKB, UniProtKB]; Remodeling Matrix Synthesis in a Rat Model of Aortocaval Fistula and the Cyclic Stretch: Impaction in Pulmonary Arterial Hypertension-Congenital Heart Disease. Publication Status: Online-Only, [RefSeq, PubMed]; TGF-alpha/EGFR signaling promotes lipopolysaccharide-induced abnormal elastin deposition and alveolar simplification., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 35, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q5RKH4", "ec_number_list": [], "go_molecular_function": "GO:0050840 extracellular matrix binding;GO:0030023 extracellular matrix constituent conferring elasticity;GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0071953 elastic fiber;GO:0031012 extracellular matrix", "go_biological_process": "GO:0085029 extracellular matrix assembly;GO:0030198 extracellular matrix organization;GO:0071300 cellular response to retinoic acid;GO:0001974 blood vessel remodeling;GO:0071456 cellular response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q99372-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43427-1", "uniprot_id": [ { "id": "GTR5_RAT", "url": "https://www.uniprot.org/uniprot/P43427", "type": "external" } ], "mass": 55543.0, "length": 502, "protein_name": "Solute carrier family 2, facilitated glucose transporter member 5", "gene_name": "Slc2a5", "organism": "Rat", "refseq_name": "solute carrier family 2, facilitated glucose transporter member 5", "refseq_ac": [ { "id": "NP_113929", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113929", "type": "external" } ], "gene_names_uniprotkb": "Slc2a5; Glut5", "gene_names_refseq": "Slc2a5", "protein_names_uniprotkb": "Solute carrier family 2, facilitated glucose transporter member 5; Fructose transporter; GLUT-5; Glucose transporter type 5, small intestine", "protein_names_refseq": "GLUT-5; fructose transporter; glucose transporter type 5, small intestine; solute carrier family 2 (facilitated glucose transporter), member 5; solute carrier family 2 (facilitated glucose/fructose transporter), member 5; solute carrier family 2, facilitated glucose transporter member 5", "tax_id": 10116, "disease": "", "pathway": " (rno:65197); (R-RNO-6798695); (R-RNO-8981373)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "12914929;21222652;26416735;8333543;8404647;9820812", "class_list": "", "function": "Crystal structures of GLUT5 from Rattus norvegicus and Bos taurus in open outward- and open inward-facing conformations, respectively, [RefSeq, PubMed]; Functions as a fructose transporter that has only low activity with other monosaccharides (PubMed:26416735, PubMed:8333543, PubMed:9820812). Can mediate the uptake of deoxyglucose, but with low efficiency (PubMed:8333543). Essential for fructose uptake in the small intestine (By similarity). Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose (By similarity). Required for the development of high blood pressure in response to high dietary fructose intake (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Functions as a fructose transporter that has only low activity with other monosaccharides. Can mediate the uptake of deoxyglucose, but with low efficiency. Essential for fructose uptake in the small intestine. Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose. Required for the development of high blood pressure in response to high dietary fructose intake., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Insulin is capable of increasing the abundance and functional activity of GLUT5 in skeletal muscle cells, most likely mediated via activation of the GLUT5 promoter, [RefSeq, PubMed]; Investigation of influence of dietary carbohydrates on expression of Glut5 in small intestine: Glut5 mRNA increased with fructose perfusion and age, a pattern that matched that of Pol II binding and histone H3 acetylation at Glut5 promoter, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0070061 fructose binding;GO:0005353 fructose transmembrane transporter activity;GO:0055056 D-glucose transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0042383 sarcolemma", "go_biological_process": "GO:0070837 dehydroascorbic acid transport;GO:1904659 D-glucose transmembrane transport;GO:0072237 metanephric proximal tubule development;GO:0009750 response to fructose;GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P43427-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43884-1", "uniprot_id": [ { "id": "PLIN1_RAT", "url": "https://www.uniprot.org/uniprot/P43884", "type": "external" } ], "mass": 55614.0, "length": 517, "protein_name": "Perilipin-1", "gene_name": "Plin1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Plin1; Peri; Plin", "gene_names_refseq": "", "protein_names_uniprotkb": "Perilipin-1; Lipid droplet-associated protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "familial partial lipodystrophy type 4 (Disease Ontology:DOID:0070205); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25629)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "22673903;34502162;7505452;9755872", "class_list": "", "function": "Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0071944 cell periphery", "go_biological_process": "GO:0070417 cellular response to cold;GO:0016042 lipid catabolic process;GO:0050995 negative regulation of lipid catabolic process;GO:0010897 negative regulation of triglyceride catabolic process;GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P43884-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97837-1", "uniprot_id": [ { "id": "DLGP2_RAT", "url": "https://www.uniprot.org/uniprot/P97837", "type": "external" } ], "mass": 118978.0, "length": 1059, "protein_name": "Disks large-associated protein 2", "gene_name": "Dlgap2", "organism": "Rat", "refseq_name": "disks large-associated protein 2", "refseq_ac": [ { "id": "NP_446353", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446353", "type": "external" } ], "gene_names_uniprotkb": "Dlgap2; Dap2", "gene_names_refseq": "DAP-2; Dlgap2; SAPAP2", "protein_names_uniprotkb": "Disks large-associated protein 2; DAP-2; PSD-95/SAP90-binding protein 2; SAP90/PSD-95-associated protein 2; SAPAP2", "protein_names_refseq": "PSD-95/SAP90-associated protein-2; PSD-95/SAP90-binding protein 2; SAP90/PSD-95-associated protein 2; discs large homolog associated protein 2; disks large-associated protein 2; postsynaptic density 95", "tax_id": 10116, "disease": "", "pathway": " (rno:116681); (R-RNO-6794361)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "15207911;22673903;24585759;34818135;9115257", "class_list": "", "function": "May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane., [UniProtKB]; Oligomeric Abeta25-35 induces the tyrosine phosphorylation of PSD-95 by SrcPTKs in rat hippocampal CA1 subfield., [RefSeq, PubMed]; Protein kinase A-phosphorylated KV1 channels in PSD95 signaling complex contribute to the resting membrane potential and diameter of cerebral arteries., [RefSeq, PubMed]; The product of this gene is a membrane-associated protein that may play a role in synapse organization and signalling in neuronal cells. [provided by RefSeq, Jun 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004385 GMP kinase activity;GO:0060090 molecular adaptor activity;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0030425 dendrite;GO:0043197 dendritic spine;GO:0045211 postsynaptic membrane;GO:0005883 neurofilament", "go_biological_process": "GO:0050804 modulation of chemical synaptic transmission;GO:0007270 neuron-neuron synaptic transmission;GO:0023052 signaling", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P97837-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24135-1", "uniprot_id": [ { "id": "PLCG2_RAT", "url": "https://www.uniprot.org/uniprot/P24135", "type": "external" } ], "mass": 147735.0, "length": 1265, "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2", "gene_name": "Plcg2", "organism": "Rat", "refseq_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2", "refseq_ac": [ { "id": "NP_058864", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058864", "type": "external" } ], "gene_names_uniprotkb": "Plcg2", "gene_names_refseq": "Plcg2", "protein_names_uniprotkb": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2; 3.1.4.11; PLC-IV; PLC-gamma-2; Phosphoinositide phospholipase C-gamma-2; Phospholipase C-IV; Phospholipase C-gamma-2", "protein_names_refseq": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2; PLC-IV; PLC-gamma-2; phosphoinositide phospholipase C-gamma-2; phosphoinositide phospholipase C; phospholipase C-IV", "tax_id": 10116, "disease": "autoinflammation, antibody deficiency, and immune dysregulation syndrome (Disease Ontology:DOID:0070615); familial cold autoinflammatory syndrome 3 (Disease Ontology:DOID:0090064)", "pathway": " (rno:29337); (R-RNO-114604); (R-RNO-166016); (R-RNO-1855204); (R-RNO-202433); (R-RNO-2029485); (R-RNO-2424491); (R-RNO-2871796); (R-RNO-2871809); (R-RNO-5607764); (R-RNO-5621480); (R-RNO-983695)", "pathway_count": 12, "publication_count": 6, "publication_id_list": "10498607;2557343;27323081;29236324;29430764;31549850", "class_list": "", "function": "Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; PLCG2 plays an important role in rat liver cell proliferation via ERK and NF-kappaB pathway by regulating the expression of BCl2, MYC and CCND1, [RefSeq, PubMed]; PLCgamma2 regulates hepatocyte growth through PKCD-dependently activating p38 MAPK and JNK MAPK pathways, [RefSeq, PubMed]; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These findings suggest that interference with PLCgamma2 expression could relieve the inhibitory effect of PLCgamma2 on hepaocyte apoptosis, thus, promote proliferation through inactivating PKCdelta-mediated JNK1/2 signaling pathway., [RefSeq, PubMed]; These results show that a recombinant adenovirus, Ad-PLCg2-shRNA, was developed and was effective at silencing the rat PLCg2 gene. This construct may contribute to the study of PLCg2 in hepatocyte apoptosis during liver regeneration Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" } ], "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0019901 protein kinase binding;GO:0097110 scaffold protein binding;GO:1990782 protein tyrosine kinase binding", "go_cellular_component": "GO:0097708 intracellular vesicle;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0045121 membrane raft", "go_biological_process": "GO:0032959 inositol trisphosphate biosynthetic process;GO:0032747 positive regulation of interleukin-23 production;GO:0070884 regulation of calcineurin-NFAT signaling cascade;GO:0001878 response to yeast;GO:0007204 positive regulation of cytosolic calcium ion concentration", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P24135-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35806-1", "uniprot_id": [ { "id": "LTBP2_RAT", "url": "https://www.uniprot.org/uniprot/O35806", "type": "external" } ], "mass": 189867.0, "length": 1764, "protein_name": "Latent-transforming growth factor beta-binding protein 2", "gene_name": "Ltbp2", "organism": "Rat", "refseq_name": "latent-transforming growth factor beta-binding protein 2", "refseq_ac": [ { "id": "NP_067597", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067597", "type": "external" } ], "gene_names_uniprotkb": "Ltbp2", "gene_names_refseq": "Ltbp2", "protein_names_uniprotkb": "Latent-transforming growth factor beta-binding protein 2; LTBP-2", "protein_names_refseq": "LTBP-2 like protein; latent-transforming growth factor beta-binding protein 2", "tax_id": 10116, "disease": "Weill-Marchesani syndrome (Disease Ontology:DOID:0050475); megalocornea (Disease Ontology:DOID:0060305); dilated cardiomyopathy (Disease Ontology:DOID:12930); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (rno:59106); (R-RNO-2129379); (R-RNO-2173789)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10028916;10743502;11104663;22673903;26479776;31512380;39288883", "class_list": "", "function": "LTBP2 down-regulated FGF2 to repress vascular smooth muscle cell proliferation and vascular remodeling in a rat model of intracranial aneurysm., [RefSeq, PubMed]; LTBP2 knockdown by siRNA reverses myocardial oxidative stress injury, fibrosis and remodelling during dilated cardiomyopathy., [RefSeq, PubMed]; May play an integral structural role in elastic-fiber architectural organization and/or assembly., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 9, "predicted_n_glycosites": 8, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0019838 growth factor binding;GO:0005509 calcium ion binding;GO:0050436 microfibril binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0043279 response to alkaloid;GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0097435 supramolecular fiber organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O35806-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62688-1", "uniprot_id": [ { "id": "PLCL1_RAT", "url": "https://www.uniprot.org/uniprot/Q62688", "type": "external" } ], "mass": 122772.0, "length": 1096, "protein_name": "Inactive phospholipase C-like protein 1", "gene_name": "Plcl1", "organism": "Rat", "refseq_name": "inactive phospholipase C-like protein 1", "refseq_ac": [ { "id": "NP_445908", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445908", "type": "external" } ], "gene_names_uniprotkb": "Plcl1", "gene_names_refseq": "Plcl1", "protein_names_uniprotkb": "Inactive phospholipase C-like protein 1; PLC-L1; PRIP1; Phospholipase C-related but catalytically inactive protein; p130", "protein_names_refseq": "130kDa-Ins(1,4,5)P3 binding protein; PLC-L1; PRIP1; inactive phospholipase C-like protein 1; p130; phospholipase C-related but catalytically inactive protein", "tax_id": 10116, "disease": "", "pathway": " (rno:84587)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11278544;11867528;12467885;22673903;8546702", "class_list": "", "function": "Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor. Acts as an inhibitor of PPP1C., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" } ], "go_molecular_function": "GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0050811 GABA receptor binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007214 gamma-aminobutyric acid signaling pathway;GO:0051209 release of sequestered calcium ion into cytosol;GO:0048015 phosphatidylinositol-mediated signaling;GO:0046488 phosphatidylinositol metabolic process;GO:0032228 regulation of synaptic transmission, GABAergic", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q62688-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BJM5-1", "uniprot_id": [ { "id": "PKHO1_RAT", "url": "https://www.uniprot.org/uniprot/Q5BJM5", "type": "external" } ], "mass": 46068.0, "length": 408, "protein_name": "Pleckstrin homology domain-containing family O member 1", "gene_name": "Plekho1", "organism": "Rat", "refseq_name": "pleckstrin homology domain-containing family O member 1", "refseq_ac": [ { "id": "NP_001020290", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020290", "type": "external" } ], "gene_names_uniprotkb": "Plekho1", "gene_names_refseq": "Ckip1; Plekho1; RGD1311487", "protein_names_uniprotkb": "Pleckstrin homology domain-containing family O member 1; PH domain-containing family O member 1", "protein_names_refseq": "CK2 interacting protein 1; PH domain-containing family O member 1; pleckstrin homology domain-containing family O member 1", "tax_id": 10116, "disease": "", "pathway": " (rno:310674)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16641100;28083909;31201843", "class_list": "", "function": "CKIP-1 alleviates hypoxia-induced cardiomyocyte injury through the up-regulation of Nrf2 antioxidant signaling via the down-regulation of Keap1, suggesting a potential role for CKIP-1 in myocardial infarction., [RefSeq, PubMed]; Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation (By similarity)., [UniProtKB]; The increased PLEKHO1 could suppress Smad-dependent BMP signaling to inhibit bone formation during aging., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0032587 ruffle membrane;GO:0036195 muscle cell projection membrane;GO:0005737 cytoplasm", "go_biological_process": "GO:0007520 myoblast fusion;GO:0008360 regulation of cell shape;GO:0072673 lamellipodium morphogenesis;GO:0051451 myoblast migration;GO:1901739 regulation of myoblast fusion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5BJM5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63767-1", "uniprot_id": [ { "id": "BCAR1_RAT", "url": "https://www.uniprot.org/uniprot/Q63767", "type": "external" } ], "mass": 104262.0, "length": 968, "protein_name": "Breast cancer anti-estrogen resistance protein 1", "gene_name": "Bcar1", "organism": "Rat", "refseq_name": "breast cancer anti-estrogen resistance protein 1 isoform 3", "refseq_ac": [ { "id": "NP_037063", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037063", "type": "external" } ], "gene_names_uniprotkb": "Bcar1; Cas; Crkas", "gene_names_refseq": "Bcar1; Cas; Crkas; P130CAS", "protein_names_uniprotkb": "Breast cancer anti-estrogen resistance protein 1; CRK-associated substrate; p130cas", "protein_names_refseq": "BCAR1, Cas family scaffold protein; BCAR1, Cas family scaffolding protein; CRK-associated substrate; breast cancer anti-estrogen resistance 1; breast cancer anti-estrogen resistance protein 1 isoform 3; breast cancer anti-estrogen resistance protein 1; v-crk-associated tyrosine kinase substrate", "tax_id": 10116, "disease": "breast cancer (Disease Ontology:DOID:1612); breast ductal carcinoma (Disease Ontology:DOID:3007)", "pathway": " (rno:25414); (R-RNO-186763); (R-RNO-372708); (R-RNO-4420097); (R-RNO-8849471)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "12480533;16245368;20623582;22673903;7780740;8070403;9360983", "class_list": "", "function": "Cas plays pivotal roles in liver development through the reorganization of the actin cytoskeleton and formation of fenestrae in sinusoidal endothelial cells., [RefSeq, PubMed]; Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion (By similarity). Implicated in induction of cell migration and cell branching (By similarity). Involved in the BCAR3-mediated inhibition of TGFB signaling (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q63766", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0015629 actin cytoskeleton;GO:0016020 membrane", "go_biological_process": "GO:0086100 endothelin receptor signaling pathway;GO:1990859 cellular response to endothelin;GO:0007015 actin filament organization;GO:0007155 cell adhesion;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q63767-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91Z79-1", "uniprot_id": [ { "id": "LIPA3_RAT", "url": "https://www.uniprot.org/uniprot/Q91Z79", "type": "external" } ], "mass": 133429.0, "length": 1192, "protein_name": "Liprin-alpha-3", "gene_name": "Ppfia3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ppfia3", "gene_names_refseq": "", "protein_names_uniprotkb": "Liprin-alpha-3; PTPRF-interacting protein alpha-3; Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:140591); (R-RNO-181429); (R-RNO-181430); (R-RNO-210500); (R-RNO-212676); (R-RNO-264642); (R-RNO-388844)", "pathway_count": 7, "publication_count": 5, "publication_id_list": "11797009;12620390;20966424;22673903;23124857", "class_list": "", "function": "May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098831 presynaptic active zone cytoplasmic component;GO:0005737 cytoplasm;GO:0045202 synapse;GO:0048786 presynaptic active zone", "go_biological_process": "GO:0048172 regulation of short-term neuronal synaptic plasticity;GO:0050808 synapse organization;GO:0007269 neurotransmitter secretion;GO:0016079 synaptic vesicle exocytosis;GO:0016081 synaptic vesicle docking", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q91Z79-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JL55-1", "uniprot_id": [ { "id": "GDE1_RAT", "url": "https://www.uniprot.org/uniprot/Q9JL55", "type": "external" } ], "mass": 37634.0, "length": 331, "protein_name": "Glycerophosphodiester phosphodiesterase 1", "gene_name": "Gde1", "organism": "Rat", "refseq_name": "glycerophosphodiester phosphodiesterase 1", "refseq_ac": [ { "id": "NP_116004", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_116004", "type": "external" } ], "gene_names_uniprotkb": "Gde1; Mir16", "gene_names_refseq": "Gde1; Mir16", "protein_names_uniprotkb": "Glycerophosphodiester phosphodiesterase 1; 3.1.4.-; 3.1.4.44; Glycerophosphoinositol glycerophosphodiesterase GDE1; Lysophospholipase D GDE1; Membrane-interacting protein of RGS16", "protein_names_refseq": "glycerophosphodiester phosphodiesterase 1; glycerophosphoinositol glycerophosphodiesterase GDE1; lysophospholipase D GDE1; membrane-interacting protein of RGS16", "tax_id": 10116, "disease": "", "pathway": " (rno:60418); (R-RNO-6814848)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10760272;12576545", "class_list": "", "function": "Hydrolyzes the phosphodiester bond of glycerophosphodiesters such as glycerophosphoinositol (GroPIns) and glycerophosphoethanolamine (GroPEth), to yield a glycerol phosphate and an alcohol (PubMed:12576545). Hydrolyzes glycerophospho-N-acylethanolamines to N-acylethanolamines in the brain and participates in bioactive N-acylethanolamine biosynthesis such as anandamide (an endocannabinoid), N-palmitoylethanolamine (an anti-inflammatory), and N-oleoylethanolamine (an anorexic). In addition, has a lysophospholipase D activity by hydrolyzing N-acyl-lysoplasmenylethanolamine (N-acyl-lysoPlsEt) to N-acylethanolamine. However lysophospholipase D activity is lower than glycerophosphodiester phosphodiesterase activity (By similarity). Has little or no activity towards glycerophosphocholine (PubMed:12576545)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6IRJ6", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.44", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.44", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0008081 phosphoric diester hydrolase activity;GO:0008889 glycerophosphodiester phosphodiesterase activity;GO:0047395 glycerophosphoinositol glycerophosphodiesterase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0006580 ethanolamine metabolic process;GO:0070291 N-acylethanolamine metabolic process;GO:0007186 G protein-coupled receptor signaling pathway;GO:0006644 phospholipid metabolic process;GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9JL55-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0R7Z9-1", "uniprot_id": [ { "id": "PLIN5_RAT", "url": "https://www.uniprot.org/uniprot/M0R7Z9", "type": "external" } ], "mass": 51805.0, "length": 475, "protein_name": "Perilipin-5", "gene_name": "Plin5", "organism": "Rat", "refseq_name": "perilipin-5", "refseq_ac": [ { "id": "NP_001128109", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001128109", "type": "external" } ], "gene_names_uniprotkb": "Plin5; Lsdp5; Oxpat", "gene_names_refseq": "Oxpat; Plin5", "protein_names_uniprotkb": "Perilipin-5; Lipid storage droplet protein 5", "protein_names_refseq": "lipid storage droplet protein 5; perilipin-5", "tax_id": 10116, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:501283)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "20198297;21885430;22127648;23353597;23408028;24303154;25552350;25804837;32296390;37202925", "class_list": "", "function": "Exposure to a maternal high fat diet resulted in higher skeletal muscle lipid and PLIN5 content in plantaris of offspring through to young adulthood., [RefSeq, PubMed]; Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Perilipin 5 Reduces Oxidative Damage Associated With Lipotoxicity by Activating the PI3K/ERK-Mediated Nrf2-ARE Signaling Pathway in INS-1 Pancreatic beta-Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Perilipin 5 regulates hepatic stellate cell activation and high-fat diet-induced non-alcoholic fatty liver disease., [RefSeq, PubMed]; These results suggest that lipotoxic protection afforded by natural PLIN5 upregulation in muscle involves molecular changes in lipid composition within LDs., [RefSeq, PubMed]; This study demonstrates, for the first time, the presence of OXPAT and TIP47 transcripts in rat hepatocytes, as well as their up-regulation with lipid accumulation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0035473 lipase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005811 lipid droplet;GO:0005829 cytosol", "go_biological_process": "GO:0032000 positive regulation of fatty acid beta-oxidation;GO:0010884 positive regulation of lipid storage;GO:0031999 negative regulation of fatty acid beta-oxidation;GO:0050995 negative regulation of lipid catabolic process;GO:2000378 negative regulation of reactive oxygen species metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "M0R7Z9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35824-1", "uniprot_id": [ { "id": "DNJA2_RAT", "url": "https://www.uniprot.org/uniprot/O35824", "type": "external" } ], "mass": 45766.0, "length": 412, "protein_name": "DnaJ homolog subfamily A member 2", "gene_name": "Dnaja2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Dnaja2", "gene_names_refseq": "", "protein_names_uniprotkb": "DnaJ homolog subfamily A member 2; RDJ2", "protein_names_refseq": "", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); liver disease (Disease Ontology:DOID:409)", "pathway": " (rno:84026); (R-RNO-3371497)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "22673903;38843836;9328291", "class_list": "", "function": "Co-chaperone of Hsc70. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0001671 ATPase activator activity", "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0018885 carbon tetrachloride metabolic process;GO:0034605 cellular response to heat;GO:0042026 protein refolding;GO:0009408 response to heat", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O35824-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06765-1", "uniprot_id": [ { "id": "PLF4_RAT", "url": "https://www.uniprot.org/uniprot/P06765", "type": "external" } ], "mass": 11287.0, "length": 105, "protein_name": "Platelet factor 4", "gene_name": "Pf4", "organism": "Rat", "refseq_name": "platelet factor 4 precursor", "refseq_ac": [ { "id": "NP_001007730", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007730", "type": "external" } ], "gene_names_uniprotkb": "Pf4; Cxcl4; Scyb4", "gene_names_refseq": "Cxcl4; PF-4; Pf4a; Pf4; RATPF4A", "protein_names_uniprotkb": "Platelet factor 4; C-X-C motif chemokine 4; PF-4", "protein_names_refseq": "C-X-C motif chemokine 4; chemokine (C-X-C motif) ligand 4; platelet factor 4 precursor", "tax_id": 10116, "disease": "antiphospholipid syndrome (Disease Ontology:DOID:2988); coronary artery disease (Disease Ontology:DOID:3393); systemic scleroderma (Disease Ontology:DOID:418); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); retinal degeneration (Disease Ontology:DOID:8466); diabetic retinopathy (Disease Ontology:DOID:8947); acute myocardial infarction (Disease Ontology:DOID:9408); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (rno:360918); (R-RNO-114608); (R-RNO-202733); (R-RNO-380108); (R-RNO-418594); (R-RNO-9769739)", "pathway_count": 6, "publication_count": 4, "publication_id_list": "22673903;38174673;3821732;8033893", "class_list": "", "function": "Chemokine released during platelet aggregation that plays a role in different biological processes including hematopoiesis, cell proliferation, differentiation, and activation. Acts via different functional receptors including CCR1, CXCR3A or CXCR3B. Upon interaction with CXCR3A receptor, induces activated T-lymphocytes migration mediated via downstream Ras/extracellular signal-regulated kinase (ERK) signaling. Neutralizes the anticoagulant effect of heparin by binding more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Plays a role in the inhibition of hematopoiesis and in the maintenance of hematopoietic stem cell (HSC) quiescence. Chemotactic for neutrophils and monocytes via CCR1. Inhibits endothelial cell proliferation. In cooperation with toll-like receptor 8/TLR8, induces chromatin remodeling and activates inflammatory gene expression via the TBK1-IRF5 axis. In addition, induces myofibroblast differentiation and collagen synthesis in different precursor cells, including endothelial cells, by stimulating endothelial-to-mesenchymal transition. Interacts with thrombomodulin/THBD to enhance the activation of protein C and thus potentiates its anticoagulant activity., [UniProtKB, UniProtKB]; PF4 induces inflammatory response through NF-kB signal pathway in rats with intracerebral haemorrhage., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0048018 receptor ligand activity;GO:0008009 chemokine activity;GO:0045236 CXCR chemokine receptor binding;GO:0048248 CXCR3 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0031982 vesicle;GO:0032991 protein-containing complex;GO:0031091 platelet alpha granule", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:2000320 negative regulation of T-helper 17 cell differentiation;GO:0006954 inflammatory response;GO:0006955 immune response;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P06765-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56741-1", "uniprot_id": [ { "id": "MYPC_RAT", "url": "https://www.uniprot.org/uniprot/P56741", "type": "external" } ], "mass": 140762.0, "length": 1274, "protein_name": "Myosin-binding protein C, cardiac-type", "gene_name": "Mybpc3", "organism": "Rat", "refseq_name": "myosin-binding protein C, cardiac-type", "refseq_ac": [ { "id": "NP_001099960", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099960", "type": "external" } ], "gene_names_uniprotkb": "Mybpc3", "gene_names_refseq": "Mybpc3", "protein_names_uniprotkb": "Myosin-binding protein C, cardiac-type; C-protein, cardiac muscle isoform; Cardiac MyBP-C", "protein_names_refseq": "cardiac MyBP-C; myosin binding protein C, cardiac; myosin-binding protein C, cardiac-type", "tax_id": 10116, "disease": "familial hypertrophic cardiomyopathy (Disease Ontology:DOID:0080326); dilated cardiomyopathy 1MM (Disease Ontology:DOID:0081158); hypertrophic cardiomyopathy 4 (Disease Ontology:DOID:0110310); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (rno:295929); (R-RNO-390522)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "22673903;26109417;27233767;29470978;30082313;31308242;34502162;9784245", "class_list": "", "function": "Both tris-phosphorylation and Ser-Asp substitutions abolished the interaction between C1mC2 and myosin sub-fragment 2 (myosin S2) in vitro, but yielded different effects on thin filament binding., [RefSeq, PubMed]; CMyBP-C acts as a sarcomeric integrator of multiple signaling pathways that determines downstream physiological function., [RefSeq, PubMed]; Phosphorylation of myosin regulatory light chain (RLC) increased and remained elevated post-MI, while phosphorylation of myosin binding protein-C (MyBP-C) was initially depressed but then increased as the hearts became decompensated., [RefSeq, PubMed]; Serine 302 in cardiac myosin binding protein-C was identified as a PKCepsilon substrate that when phosphorylated contributed to the suppression of contraction and Ca(2+) transients by PKCepsilon following ET-1 stimulation., [RefSeq, PubMed]; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0017022 myosin binding;GO:0008307 structural constituent of muscle", "go_cellular_component": "GO:0030017 sarcomere;GO:0031430 M band;GO:0030016 myofibril;GO:0031672 A band;GO:0097512 cardiac myofibril", "go_biological_process": "GO:0031034 myosin filament assembly;GO:0007155 cell adhesion;GO:0008016 regulation of heart contraction;GO:0003007 heart morphogenesis;GO:0060048 cardiac muscle contraction", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P56741-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62168-1", "uniprot_id": [ { "id": "NCS1_RAT", "url": "https://www.uniprot.org/uniprot/P62168", "type": "external" } ], "mass": 21879.0, "length": 190, "protein_name": "Neuronal calcium sensor 1", "gene_name": "Ncs1", "organism": "Rat", "refseq_name": "neuronal calcium sensor 1", "refseq_ac": [ { "id": "NP_077342", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077342", "type": "external" } ], "gene_names_uniprotkb": "Ncs1; Flup; Freq", "gene_names_refseq": "Freq; Ncs1", "protein_names_uniprotkb": "Neuronal calcium sensor 1; Frequenin homolog; Frequenin-like protein; Frequenin-like ubiquitous protein; NCS-1", "protein_names_refseq": "NCS-1; frequenin-like protein; frequenin-like ubiquitous protein; neuronal calcium sensor 1", "tax_id": 10116, "disease": "", "pathway": " (rno:65153)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10514519;11526106;17502602;18199453;19109914;21035569;22521426;24978930;25979333;27796528;7488079", "class_list": "", "function": "Characterized individual residues in both non-myristoylated and myristoylated NCS-1 that access alternate states by measuring nonlinear temperature dependence of the backbone amide-proton ((1)H(N)) chemical shifts, [RefSeq, PubMed]; In the Ca(2+)/NCS-1.D2R peptide complex, the C-terminal region adopts a 310 helix-turn-310 helix, whereas in the GRK1 peptide complex it forms an a-helix, [RefSeq, PubMed]; NCS-1 was decreased in prefrontal cortex 48 hours after sepsis induction, [RefSeq, PubMed]; Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin. Stimulates PI4KB kinase activity. Involved in long-term synaptic plasticity through its interaction with PICK1. May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Physical exercise could be modulating NCS-1 in an activity dependent manner, for specific neural substrates, [RefSeq, PubMed]; Three critical amino acid residues of N. crassa NCS-1 and its functional conservation across species using the orthologue from R. norvegicus, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P36610;Q9UK26", "ec_number_list": [], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0019901 protein kinase binding;GO:0005509 calcium ion binding;GO:0005245 voltage-gated calcium channel activity;GO:0008427 calcium-dependent protein kinase inhibitor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0044305 calyx of Held;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0050850 positive regulation of calcium-mediated signaling;GO:0009966 regulation of signal transduction;GO:0010975 regulation of neuron projection development;GO:0099509 regulation of presynaptic cytosolic calcium ion concentration;GO:0045921 positive regulation of exocytosis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P62168-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70499-1", "uniprot_id": [ { "id": "IFNB_RAT", "url": "https://www.uniprot.org/uniprot/P70499", "type": "external" } ], "mass": 22073.0, "length": 184, "protein_name": "Interferon beta", "gene_name": "Ifnb1", "organism": "Rat", "refseq_name": "interferon beta precursor", "refseq_ac": [ { "id": "NP_062000", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062000", "type": "external" } ], "gene_names_uniprotkb": "Ifnb1; Ifnb", "gene_names_refseq": "If1da1; Ifnb1; Ifnb", "protein_names_uniprotkb": "Interferon beta; IFN-beta", "protein_names_refseq": "IFN-beta; interferon 1da1; interferon beta 1, fibroblast; interferon beta precursor", "tax_id": 10116, "disease": "primary bacterial infectious disease (Disease Ontology:DOID:0050338); 46,XY gonadal dysgenesis with minifascicular neuropathy (Disease Ontology:DOID:0051055); COVID-19 (Disease Ontology:DOID:0080600); 46,XY sex reversal 7 (Disease Ontology:DOID:0111774); 46,XY complete gonadal dysgenesis (Disease Ontology:DOID:14448); transient cerebral ischemia (Disease Ontology:DOID:224); multiple sclerosis (Disease Ontology:DOID:2377); cerebral infarction (Disease Ontology:DOID:3526); proteinuria (Disease Ontology:DOID:576); retinoblastoma (Disease Ontology:DOID:768)", "pathway": " (rno:24481); (R-RNO-909733); (R-RNO-912694)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "16641100;33160814;9126338", "class_list": "", "function": "In cardiac fibroblasts, interferon-beta attenuates differentiation, collagen synthesis, and TGF-beta1-induced collagen gel contraction., [RefSeq, PubMed]; Type I interferon cytokine that plays a key role in the innate immune response to infection, developing tumors and other inflammatory stimuli. Signals via binding to high-affinity (IFNAR2) and low-affinity (IFNAR1) heterodimeric receptor, activating the canonical Jak-STAT signaling pathway resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response, such as antiviral proteins, regulators of cell proliferation and differentiation, and immunoregulatory proteins (By similarity). Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways. Elicits a wide variety of responses, including antiviral and antibacterial activities, and can regulate the development of B-cells, myelopoiesis and lipopolysaccharide (LPS)-inducible production of tumor necrosis factor. Plays a role in neuronal homeostasis by regulating dopamine turnover and protecting dopaminergic neurons: acts by promoting neuronal autophagy and alpha-synuclein clearance, thereby preventing dopaminergic neuron loss. IFNB1 is more potent than interferon-alpha (IFN-alpha) in inducing the apoptotic and antiproliferative pathways required for control of tumor cell growth (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005132 type I interferon receptor binding;GO:0008811 chloramphenicol O-acetyltransferase activity;GO:0005126 cytokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0071360 cellular response to exogenous dsRNA;GO:1904465 negative regulation of matrix metallopeptidase secretion;GO:0002312 B cell activation involved in immune response;GO:0071359 cellular response to dsRNA;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P70499-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70536-1", "uniprot_id": [ { "id": "OXYR_RAT", "url": "https://www.uniprot.org/uniprot/P70536", "type": "external" } ], "mass": 42869.0, "length": 388, "protein_name": "Oxytocin receptor", "gene_name": "Oxtr", "organism": "Rat", "refseq_name": "oxytocin receptor", "refseq_ac": [ { "id": "NP_037003", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037003", "type": "external" } ], "gene_names_uniprotkb": "Oxtr; Otr", "gene_names_refseq": "OT-R; OTR1; OTR; Oxtr", "protein_names_uniprotkb": "Oxytocin receptor; OT-R", "protein_names_refseq": "oxcytocin receptor; oxytocin receptor", "tax_id": 10116, "disease": "Charcot-Marie-Tooth disease type 3 (Disease Ontology:DOID:0050540); alcohol dependence (Disease Ontology:DOID:0050741); Charcot-Marie-Tooth disease type 1D (Disease Ontology:DOID:0110150); congenital hypomyelinating neuropathy 1 (Disease Ontology:DOID:0110195); hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); impulse control disorder (Disease Ontology:DOID:10937); personality disorder (Disease Ontology:DOID:1510); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); motor peripheral neuropathy (Disease Ontology:DOID:2477); substance abuse (Disease Ontology:DOID:302); middle cerebral artery infarction (Disease Ontology:DOID:3525)", "pathway": " (rno:25342); (R-RNO-388479); (R-RNO-416476)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10497238;11606726;207528;22673903;35104164;35361281;35785764;37002874;38203176;6313158;7577971;7816817;9548257", "class_list": "", "function": "Brief versus long maternal separation in lactating rats: Consequences on maternal behavior, emotionality, and brain oxytocin receptor binding., [RefSeq, PubMed]; Delivery-Dependent Shift in Oxytocin-Responsive Cell Population in the Central Amygdala of the Female Rat., [RefSeq, PubMed]; G protein-coupled receptor for oxytocin (OXT), a neuropeptide hormone released by the posterior pituitary gland that plays a key role in social behavior and other biological processes, such as milk ejection (PubMed:10497238, PubMed:11606726, PubMed:35104164, PubMed:9548257). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as phospholipase C (PubMed:10497238). OXTR is mainly coupled to G(q) G proteins and mediates production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca(2+) ions from intracellular stores, respectively (PubMed:10497238). In presence of high levels of oxytocin, also coupled to G(i) G proteins, mediating inhibition of adenylate cyclase activity (PubMed:10497238). Central release of oxytocin plays essential roles in social behavior, such as maternal care, social cognition and affiliative behaviors, triggering signaling that modulates neural circuits by altering ion channel activity, changing intrinsic neuronal properties and modifying synaptic transmission (both excitatory and inhibitory) (PubMed:11606726). Peripheral release of oxytocin (secretion into the bloodstream) promotes various processes, such as parturition, lactation or osteoblast differentiation (By similarity). OXTR-mediated signaling promotes milk ejection by triggering and strengthening contraction of the smooth muscle of mammary gland (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Peripheral Branch Injury Induces Oxytocin Receptor Expression at the Central Axon Terminals of Primary Sensory Neurons. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system., [UniProtKB, UniProtKB, UniProtKB]; Regulation of oxytocin receptor gene expression in obsessive-compulsive disorder: a possible role for the microbiota-host epigenetic axis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q53ZC5", "ec_number_list": [], "go_molecular_function": "GO:0017046 peptide hormone binding;GO:0004990 oxytocin receptor activity;GO:0035255 ionotropic glutamate receptor binding;GO:0005000 vasopressin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0016324 apical plasma membrane;GO:0005902 microvillus", "go_biological_process": "GO:0060406 positive regulation of penile erection;GO:0010701 positive regulation of norepinephrine secretion;GO:0001967 suckling behavior;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P70536-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97710-1", "uniprot_id": [ { "id": "SHPS1_RAT", "url": "https://www.uniprot.org/uniprot/P97710", "type": "external" } ], "mass": 55691.0, "length": 509, "protein_name": "Tyrosine-protein phosphatase non-receptor type substrate 1", "gene_name": "Sirpa", "organism": "Rat", "refseq_name": "tyrosine-protein phosphatase non-receptor type substrate 1 isoform X2", "refseq_ac": [ { "id": "XP_017446986", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017446986", "type": "external" } ], "gene_names_uniprotkb": "Sirpa; Bit; Mfr; Ptpns1; Shps1; Sirp", "gene_names_refseq": "Bit; Ptpns1; SHPS-1; Sirpa", "protein_names_uniprotkb": "Tyrosine-protein phosphatase non-receptor type substrate 1; Bit; Brain Ig-like molecule with tyrosine-based activation motifs; CD172 antigen-like family member A; Inhibitory receptor SHPS-1; Macrophage fusion receptor; Macrophage membrane protein MFP150; SHP substrate 1; SHPS-1; Signal-regulatory protein alpha-1; Sirp-alpha-1", "protein_names_refseq": "tyrosine-protein phosphatase non-receptor type substrate 1 isoform X2", "tax_id": 10116, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684); oropharynx cancer (Disease Ontology:DOID:8557)", "pathway": " (rno:25528); (R-RNO-202733); (R-RNO-2172127); (R-RNO-391160); (R-RNO-6798695)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "10.1039/D0MO00044B;24090084;24511121;34106099;38843836;8943344;9271230;9344856;9535915;9712053;9774638", "class_list": "", "function": "Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Plays a role in antiviral immunity and limits new world arenavirus infection by decreasing virus internalization (By similarity). Receptor for THBS1 (PubMed:24511121). Interaction with THBS1 stimulates phosphorylation of SIRPA (PubMed:24511121). In response to THBS1, involved in ROS signaling in non-phagocytic cells, stimulating NADPH oxidase-derived ROS production (PubMed:24511121)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 4, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 29, "disease_count": 2, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "O08951;O70426;Q9QWI5", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:1990405 protein antigen binding;GO:0019903 protein phosphatase binding;GO:0030695 GTPase regulator activity;GO:0045309 protein phosphorylated amino acid binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0032651 regulation of interleukin-1 beta production;GO:0006911 phagocytosis, engulfment;GO:0007015 actin filament organization;GO:0016477 cell migration;GO:0032715 negative regulation of interleukin-6 production", "synthesized_glycan_count": 0, "hit_score": 4.6, "record_id": "P97710-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000001000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1LZ53-1", "uniprot_id": [ { "id": "DNM3A_RAT", "url": "https://www.uniprot.org/uniprot/Q1LZ53", "type": "external" } ], "mass": 101669.0, "length": 908, "protein_name": "DNA (cytosine-5)-methyltransferase 3A", "gene_name": "Dnmt3a", "organism": "Rat", "refseq_name": "DNA (cytosine-5)-methyltransferase 3A isoform 2", "refseq_ac": [ { "id": "NP_001003957", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003957", "type": "external" } ], "gene_names_uniprotkb": "Dnmt3a", "gene_names_refseq": "Dnmt3a", "protein_names_uniprotkb": "DNA (cytosine-5)-methyltransferase 3A; 2.1.1.-; 2.1.1.37; Cysteine methyltransferase DNMT3A; Dnmt3a", "protein_names_refseq": "DNA (cytosine-5)-methyltransferase 3A isoform 2; DNA (cytosine-5)-methyltransferase 3A; DNA (cytosine-5-)-methyltransferase 3 alpha; DNA methyltransferase 3A; cysteine methyltransferase DNMT3A", "tax_id": 10116, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); Tatton-Brown-Rahman syndrome (Disease Ontology:DOID:0112339); stomach cancer (Disease Ontology:DOID:10534); lung cancer (Disease Ontology:DOID:1324); prostatitis (Disease Ontology:DOID:14654); congenital heart disease (Disease Ontology:DOID:1682); endometriosis of uterus (Disease Ontology:DOID:288); endometriosis (Disease Ontology:DOID:289); middle cerebral artery infarction (Disease Ontology:DOID:3525); lung carcinoma (Disease Ontology:DOID:3905); T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603); hepatocellular carcinoma (Disease Ontology:DOID:684); chronic myeloid leukemia (Disease Ontology:DOID:8552); autoimmune thrombocytopenic purpura (Disease Ontology:DOID:8924); acute myeloid leukemia (Disease Ontology:DOID:9119); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:444984); (R-RNO-212300); (R-RNO-3214858)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "15203217;22673903;33230530;36430472;37592110;37804593;37986543", "class_list": "", "function": "DNA Methyltransferase 3A Is Involved in the Sustained Effects of Chronic Stress on Synaptic Functions and Behaviors., [RefSeq, PubMed]; DNMT3a-mediated methylation of PPARgamma promote intervertebral disc degeneration by regulating the NF-kappaB pathway., [RefSeq, PubMed]; Identification of Epigenetic Interactions between MicroRNA-30c-5p and DNA Methyltransferases in Neuropathic Pain. Publication Status: Online-Only, [RefSeq, PubMed]; MiR-199a-3p mediates bone cancer pain through upregulation of dnmt3a expression in spinal dorsal horn neurons., [RefSeq, PubMed]; POU2F1/DNMT3a Pathway Participates in Neuropathic Pain by Hypermethylation-Mediated LRFN4 Downregulation Following Oxaliplatin Treatment., [RefSeq, PubMed]; Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity (By similarity). Also has weak auto-methylation activity on Cys-706 in absence of DNA (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1LZ52", "ec_number_list": [ { "id": "2.1.1.356", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.356", "type": "external" }, { "id": "2.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.37", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0003886 DNA (cytosine-5-)-methyltransferase activity;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000775 chromosome, centromeric region;GO:0016363 nuclear matrix", "go_biological_process": "GO:0043045 epigenetic programming of gene expression;GO:1900039 positive regulation of cellular response to hypoxia;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q1LZ53-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63664-1", "uniprot_id": [ { "id": "KCNJ8_RAT", "url": "https://www.uniprot.org/uniprot/Q63664", "type": "external" } ], "mass": 47963.0, "length": 424, "protein_name": "ATP-sensitive inward rectifier potassium channel 8", "gene_name": "Kcnj8", "organism": "Rat", "refseq_name": "ATP-sensitive inward rectifier potassium channel 8", "refseq_ac": [ { "id": "NP_058795", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058795", "type": "external" } ], "gene_names_uniprotkb": "Kcnj8", "gene_names_refseq": "Kcnj8; Kir6.1; UKATP1; uKATP-1", "protein_names_uniprotkb": "ATP-sensitive inward rectifier potassium channel 8; Inward rectifier K(+) channel Kir6.1; Potassium channel, inwardly rectifying subfamily J member 8; uKATP-1", "protein_names_refseq": "ATP-sensitive inward rectifier potassium channel 8; Inwardly rectifying potassium channel gene, subfamily J-8 (ATP sensitive); inward rectifier K(+) channel Kir6.1; inwardly rectifier K(+) channel Kir6.1; potassium channel, inwardly rectifying subfamily J member 8; potassium voltage-gated channel subfamily J member 8", "tax_id": 10116, "disease": "hypertrichotic osteochondrodysplasia Cantu type (Disease Ontology:DOID:0060569); Parkinsonism (Disease Ontology:DOID:0080855); hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); coronary artery disease (Disease Ontology:DOID:3393); rheumatoid arthritis (Disease Ontology:DOID:7148)", "pathway": " (rno:25472); (R-RNO-1296025)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11726534;27035370;28842488;29353068;33523201;38763521;7890693", "class_list": "", "function": "Both Kir6.1(V65M) and Kir6.2(V64M) mutations essentially abolish high-affinity sensitivity to the KATP blocker glibenclamide in both intact cells and excised patches. This raises the possibility that, at least for some CS mutations, sulfonylurea therapy may not prove to be successful and highlights the need for detailed pharmacogenomic analyses of CS mutations., [RefSeq, PubMed]; Data suggest that sarc and mitoKATP channel populations play distinct protective roles, triggered by PKC and/or adenosine, during chemically induced hypoxia/reoxygenation., [RefSeq, PubMed]; Identification and characterisation of functional Kir6.1-containing ATP-sensitive potassium channels in the cardiac ventricular sarcolemmal membrane., [RefSeq, PubMed]; In vascular smooth muscle KATP channel subunits Kir6.1 and SUR2B contribute to modify the functionality of this channel in hypertension with age., [RefSeq, PubMed]; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium (PubMed:7890693). Can form a sulfonyllurea-sensitive but ATP-insensitive potassium channel with ABCC9 (By similarity)., [UniProtKB, PubMed, UniProtKB]; It can be concluded that mitoKATP channels regulate mitochondrial dynamics to participate in rotenone-induced Parkinson's disease mainly attributes to the pore subunits of Kir6.1., [RefSeq, PubMed]; KATP Opener Attenuates Diabetic-Induced Muller Gliosis and Inflammation by Modulating Kir6.1 in Microglia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JM49;Q9JM50", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization;GO:0005524 ATP binding;GO:0015272 ATP-activated inward rectifier potassium channel activity;GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity;GO:0017098 sulfonylurea receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0008282 inward rectifying potassium channel;GO:0042383 sarcolemma", "go_biological_process": "GO:0072359 circulatory system development;GO:0098915 membrane repolarization during ventricular cardiac muscle cell action potential;GO:0044546 NLRP3 inflammasome complex assembly;GO:0001774 microglial cell activation;GO:0002931 response to ischemia", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q63664-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91Z80-1", "uniprot_id": [ { "id": "LIPA4_RAT", "url": "https://www.uniprot.org/uniprot/Q91Z80", "type": "external" } ], "mass": 118004.0, "length": 1043, "protein_name": "Liprin-alpha-4", "gene_name": "Ppfia4", "organism": "Rat", "refseq_name": "liprin-alpha-4", "refseq_ac": [ { "id": "NP_536334", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_536334", "type": "external" } ], "gene_names_uniprotkb": "Ppfia4", "gene_names_refseq": "Ppfia4", "protein_names_uniprotkb": "Liprin-alpha-4; PTPRF-interacting protein alpha-4; Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-4", "protein_names_refseq": "PTPRF interacting protein alpha 4; liprin-alpha-4; protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-4; protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4", "tax_id": 10116, "disease": "", "pathway": " (rno:140592); (R-RNO-181429); (R-RNO-181430); (R-RNO-210500); (R-RNO-212676); (R-RNO-264642); (R-RNO-388844)", "pathway_count": 7, "publication_count": 6, "publication_id_list": "11797009;11931740;12522103;12629171;22673903;29393594", "class_list": "", "function": "May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0009986 cell surface;GO:0045202 synapse;GO:0048786 presynaptic active zone", "go_biological_process": "GO:0050808 synapse organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q91Z80-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99MZ4-1", "uniprot_id": [ { "id": "GGT7_RAT", "url": "https://www.uniprot.org/uniprot/Q99MZ4", "type": "external" } ], "mass": 70383.0, "length": 662, "protein_name": "Glutathione hydrolase 7", "gene_name": "Ggt7", "organism": "Rat", "refseq_name": "glutathione hydrolase 7", "refseq_ac": [ { "id": "NP_569107", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_569107", "type": "external" } ], "gene_names_uniprotkb": "Ggt7; Ggtl3", "gene_names_refseq": "Ggt7; Ggtl3", "protein_names_uniprotkb": "Glutathione hydrolase 7; 2.3.2.2; 3.4.19.13; GGT 7; Gamma-glutamyltransferase 7; Gamma-glutamyltransferase-like 3; Gamma-glutamyltranspeptidase 7", "protein_names_refseq": "GGT 7; gamma-glutamyltransferase-like 3; gamma-glutamyltranspeptidase 7; glutathione hydrolase 7", "tax_id": 10116, "disease": "", "pathway": " (rno:156275); (R-RNO-174403); (R-RNO-5423646); (R-RNO-9753281)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "22673903;24090084", "class_list": "", "function": "Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Hydrolyzes and transfers gamma-glutamyl moieties from glutathione and other gamma-glutamyl compounds to acceptors., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 8, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.2", "type": "external" }, { "id": "3.4.19.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.13", "type": "external" }, { "id": "3.4.19.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.14", "type": "external" } ], "go_molecular_function": "GO:0036374 glutathione hydrolase activity;GO:0103068 leukotriene C4 gamma-glutamyl transferase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006750 glutathione biosynthetic process;GO:0006751 glutathione catabolic process;GO:1902883 negative regulation of response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q99MZ4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JM01-1", "uniprot_id": [ { "id": "CDKL3_RAT", "url": "https://www.uniprot.org/uniprot/Q9JM01", "type": "external" } ], "mass": 67553.0, "length": 593, "protein_name": "Cyclin-dependent kinase-like 3", "gene_name": "Cdkl3", "organism": "Rat", "refseq_name": "cyclin-dependent kinase-like 3", "refseq_ac": [ { "id": "NP_068540", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068540", "type": "external" } ], "gene_names_uniprotkb": "Cdkl3; Nkiatre", "gene_names_refseq": "Cdkl3; Nkiatreb; Nkiatre", "protein_names_uniprotkb": "Cyclin-dependent kinase-like 3; 2.7.11.22; Serine/threonine protein kinase NKIATRE", "protein_names_refseq": "cyclin-dependent kinase-like 3; serine/threonine kinase NKIATRE beta; serine/threonine protein kinase NKIATRE", "tax_id": 10116, "disease": "", "pathway": " (rno:60396)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11161806;22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JM02", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0050775 positive regulation of dendrite morphogenesis;GO:0097484 dendrite extension;GO:0030517 negative regulation of axon extension", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9JM01-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48768-1", "uniprot_id": [ { "id": "NAC2_RAT", "url": "https://www.uniprot.org/uniprot/P48768", "type": "external" } ], "mass": 100523.0, "length": 921, "protein_name": "Sodium/calcium exchanger 2", "gene_name": "Slc8a2", "organism": "Rat", "refseq_name": "sodium/calcium exchanger 2 isoform 1 precursor", "refseq_ac": [ { "id": "NP_511174", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_511174", "type": "external" } ], "gene_names_uniprotkb": "Slc8a2; Ncx2", "gene_names_refseq": "Ncx2; Slc8a2", "protein_names_uniprotkb": "Sodium/calcium exchanger 2; Na(+)/Ca(2+)-exchange protein 2; Solute carrier family 8 member 2", "protein_names_refseq": "Na(+)/Ca(2+)-exchange protein 2; sodium/calcium exchanger 2 isoform 1 precursor; sodium/calcium exchanger 2; solute carrier family 8 (sodium/calcium exchanger), member 2; solute carrier family 8 member 2", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); status epilepticus (Disease Ontology:DOID:1824); brain ischemia (Disease Ontology:DOID:2316)", "pathway": " (rno:140447); (R-RNO-418359); (R-RNO-425561); (R-RNO-5578775)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "12377375;12502534;16914199;23506867;28428550;35114589;36077454;8021246;8798769;9486131", "class_list": "", "function": "Brain ischemia regulates gene expression levels of Na+/Ca2+ exchanger isoform NCX2, especially in cerebral cortex., [RefSeq, PubMed]; Data show a general mechanism for regulatory coupling associated with Ca2+ interactions with regulatory CBD domains of NCX1, NCX2, and NCX3 isoforms and their splice variants, where the dynamic effects of alternative splicing on conformational dynamics of the two-domain regulatory tandem (CBD12) control the contribution of a given isoform/splice variant to dynamic handling of cytosolic Ca2+ oscillations in many cell type. Publication Status: Online-Only, [RefSeq, PubMed]; Gene expression regulation in developing rat brain, [RefSeq, PubMed]; Identification and characterization of the promoter and transcription factors regulating the expression of cerebral sodium/calcium exchanger 2 (NCX2) gene., [RefSeq, PubMed]; Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed:8021246, PubMed:9486131). Contributes to cellular Ca(2+) homeostasis in excitable cells (By similarity). Contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory (By similarity). Plays a role in regulating urinary Ca(2+) and Na(+) excretion (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Sodium-Calcium Exchanger 2: A Pivotal Role in Oxaliplatin Induced Peripheral Neurotoxicity and Axonal Damage? Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0046872 metal ion binding;GO:0005432 calcium:sodium antiporter activity;GO:0015081 sodium ion transmembrane transporter activity;GO:0015085 calcium ion transmembrane transporter activity", "go_cellular_component": "GO:0005874 microtubule;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0016323 basolateral plasma membrane;GO:0030424 axon", "go_biological_process": "GO:0048172 regulation of short-term neuronal synaptic plasticity;GO:0002931 response to ischemia;GO:0007611 learning or memory;GO:0007612 learning;GO:0007613 memory", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P48768-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97564-1", "uniprot_id": [ { "id": "GPAT1_RAT", "url": "https://www.uniprot.org/uniprot/P97564", "type": "external" } ], "mass": 93715.0, "length": 828, "protein_name": "Glycerol-3-phosphate acyltransferase 1, mitochondrial", "gene_name": "Gpam", "organism": "Rat", "refseq_name": "glycerol-3-phosphate acyltransferase 1, mitochondrial", "refseq_ac": [ { "id": "NP_058970", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058970", "type": "external" } ], "gene_names_uniprotkb": "Gpam; Gpat1", "gene_names_refseq": "Gpam", "protein_names_uniprotkb": "Glycerol-3-phosphate acyltransferase 1, mitochondrial; 2.3.1.15; GPAT-1", "protein_names_refseq": "GPAT-1; GPAT; glycerol-3-phosphate acyltransferase 1, mitochondrial", "tax_id": 10116, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); nephrotic syndrome (Disease Ontology:DOID:1184); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:29653); (R-RNO-1483166); (R-RNO-75109)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10446428;10924502;12065578;12207885;16641100;19682972;22673903;22905194;38843836", "class_list": "", "function": "Casein kinase II stimulates rat liver mitochondrial glycerophosphate acyltransferase activity, [RefSeq, PubMed]; ChREBP and SREBP-1 bind to the mtGPAT distal promoter., [RefSeq, PubMed]; Gpam regulation in rats in response to exercise, [RefSeq, PubMed]; Mitochondrial membrane protein that catalyzes the essential first step of biosynthesis of glycerolipids such as triglycerides, phosphatidic acids and lysophosphatidic acids (PubMed:10446428, PubMed:22905194). Esterifies acyl-group from acyl-coenzyme A (acyl-CoA) to the sn-1 position of glycerol-3-phosphate, to produce lysophosphatidic acid (PubMed:10446428, PubMed:22905194). Has a narrow hydrophobic binding cleft that selects for a linear acyl chain (By similarity). Catalytic activity is higher for substrates with a 16-carbon acyl chain (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35349;P97565;P97566", "ec_number_list": [ { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.3.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.15", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67", "type": "external" }, { "id": "2.3.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25", "type": "external" } ], "go_molecular_function": "GO:0004366 glycerol-3-phosphate O-acyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005886 plasma membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0006650 glycerophospholipid metabolic process;GO:0006631 fatty acid metabolic process;GO:0006637 acyl-CoA metabolic process;GO:0006641 triglyceride metabolic process;GO:0006654 phosphatidic acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P97564-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64632-1", "uniprot_id": [ { "id": "ITB4_RAT", "url": "https://www.uniprot.org/uniprot/Q64632", "type": "external" } ], "mass": 200589.0, "length": 1807, "protein_name": "Integrin beta-4", "gene_name": "Itgb4", "organism": "Rat", "refseq_name": "integrin beta-4 precursor", "refseq_ac": [ { "id": "NP_037312", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037312", "type": "external" } ], "gene_names_uniprotkb": "Itgb4", "gene_names_refseq": "Itgb4", "protein_names_uniprotkb": "Integrin beta-4; GP150", "protein_names_refseq": "GP150; integrin beta-4 precursor; integrin beta-4", "tax_id": 10116, "disease": "small intestine carcinoid neuroendocrine tumor (Disease Ontology:DOID:0050925); junctional epidermolysis bullosa with pyloric atresia (Disease Ontology:DOID:0060733); junctional epidermolysis bullosa non-Herlitz type (Disease Ontology:DOID:0060738); dilated cardiomyopathy 3B (Disease Ontology:DOID:0110461); intellectual disability (Disease Ontology:DOID:1059); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); dilated cardiomyopathy (Disease Ontology:DOID:12930); cognitive disorder (Disease Ontology:DOID:1561); status epilepticus (Disease Ontology:DOID:1824); junctional epidermolysis bullosa (Disease Ontology:DOID:3209); brain edema (Disease Ontology:DOID:4724); congestive heart failure (Disease Ontology:DOID:6000); muscular atrophy (Disease Ontology:DOID:767); retinal degeneration (Disease Ontology:DOID:8466); Becker muscular dystrophy (Disease Ontology:DOID:9883); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (rno:25724); (R-RNO-3000170); (R-RNO-446107)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "22673903;32220495;9074510", "class_list": "", "function": "Astrocytes increase exosomal secretion of oligodendrocyte precursor cells to promote their proliferation via integrin beta4-mediated cell adhesion., [RefSeq, PubMed]; Integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0046872 metal ion binding;GO:0001664 G protein-coupled receptor binding;GO:0050839 cell adhesion molecule binding;GO:0038132 neuregulin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0005938 cell cortex", "go_biological_process": "GO:0007155 cell adhesion;GO:0007229 integrin-mediated signaling pathway;GO:0016477 cell migration;GO:0046847 filopodium assembly;GO:0007160 cell-matrix adhesion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q64632-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1EC95-1", "uniprot_id": [ { "id": "HEAT6_RAT", "url": "https://www.uniprot.org/uniprot/A1EC95", "type": "external" } ], "mass": 136505.0, "length": 1252, "protein_name": "HEAT repeat-containing protein 6", "gene_name": "Heatr6", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Heatr6", "gene_names_refseq": "", "protein_names_uniprotkb": "HEAT repeat-containing protein 6", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:497972)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17218081;22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A1EC95-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1L1K8-1", "uniprot_id": [ { "id": "HABP4_RAT", "url": "https://www.uniprot.org/uniprot/A1L1K8", "type": "external" } ], "mass": 45826.0, "length": 411, "protein_name": "Intracellular hyaluronan-binding protein 4", "gene_name": "Habp4", "organism": "Rat", "refseq_name": "intracellular hyaluronan-binding protein 4", "refseq_ac": [ { "id": "NP_001073409", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073409", "type": "external" } ], "gene_names_uniprotkb": "Habp4", "gene_names_refseq": "Habp4; IHABP-4; IHABP4", "protein_names_uniprotkb": "Intracellular hyaluronan-binding protein 4; Hyaluronan-binding protein 4; IHABP-4; IHABP4; Ki-1/57 intracellular antigen", "protein_names_refseq": "hyaluronic acid binding protein 4; intracellular hyaluronan-binding protein 4; ki-1/57 intracellular antigen", "tax_id": 10116, "disease": "", "pathway": " (rno:361196); (R-RNO-114608)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "15862299;22673903", "class_list": "", "function": "Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (By similarity). Acts via its association with EEF2/eEF2 factor at the A-site of the ribosome, promoting ribosome stabilization in an inactive state compatible with storage (By similarity). Plays a key role in ribosome hibernation in the mature oocyte by promoting ribosome stabilization (By similarity). Ribosomes, which are produced in large quantities during oogenesis, are stored and translationally repressed in the oocyte and early embryo (By similarity). Also binds RNA, regulating transcription and pre-mRNA splicing. Binds (via C-terminus) to poly(U) RNA. Seems to play a role in PML-nuclear bodies formation (By similarity). Negatively regulates DNA-binding activity of the transcription factor MEF2C in myocardial cells in response to mechanical stress (PubMed:15862299)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0043022 ribosome binding;GO:0061770 translation elongation factor binding;GO:0032183 SUMO binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0030578 PML body organization;GO:0033120 positive regulation of RNA splicing;GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A1L1K8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZJP6-1", "uniprot_id": [ { "id": "MYO10_RAT", "url": "https://www.uniprot.org/uniprot/D3ZJP6", "type": "external" } ], "mass": 237262.0, "length": 2060, "protein_name": "Unconventional myosin-X", "gene_name": "Myo10", "organism": "Rat", "refseq_name": "unconventional myosin-X", "refseq_ac": [ { "id": "NP_001388751", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001388751", "type": "external" } ], "gene_names_uniprotkb": "Myo10", "gene_names_refseq": "Myo10", "protein_names_uniprotkb": "Unconventional myosin-X; Unconventional myosin-10", "protein_names_refseq": "unconventional myosin-10; unconventional myosin-X; unconventionnal myosin-X", "tax_id": 10116, "disease": "", "pathway": " (rno:310178); (R-RNO-2029482)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21965296;22673903", "class_list": "", "function": "Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as a plus end-directed motor. Moves with higher velocity and takes larger steps on actin bundles than on single actin filaments (By similarity). The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation. Plays a role in formation of the podosome belt in osteoclasts (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0051015 actin filament binding;GO:0030507 spectrin binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0030027 lamellipodium;GO:0043025 neuronal cell body", "go_biological_process": "GO:0022409 positive regulation of cell-cell adhesion;GO:0008360 regulation of cell shape;GO:0051489 regulation of filopodium assembly;GO:0030705 cytoskeleton-dependent intracellular transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZJP6-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZTT2-1", "uniprot_id": [ { "id": "LYPD6_RAT", "url": "https://www.uniprot.org/uniprot/D3ZTT2", "type": "external" } ], "mass": 19051.0, "length": 171, "protein_name": "Ly6/PLAUR domain-containing protein 6", "gene_name": "Lypd6", "organism": "Rat", "refseq_name": "ly6/PLAUR domain-containing protein 6 precursor", "refseq_ac": [ { "id": "NP_001406611", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001406611", "type": "external" } ], "gene_names_uniprotkb": "Lypd6", "gene_names_refseq": "Lypd6", "protein_names_uniprotkb": "Ly6/PLAUR domain-containing protein 6", "protein_names_refseq": "LY6/PLAUR domain containing 6B-like; ly6/PLAUR domain-containing protein 6 precursor; ly6/PLAUR domain-containing protein 6", "tax_id": 10116, "disease": "", "pathway": " (rno:679564)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "27344019;34631692", "class_list": "", "function": "Acts as a modulator of nicotinic acetylcholine receptors (nAChRs) function in the brain (PubMed:27344019). Inhibits nicotine-induced Ca(2+) influx through nAChRs (By similarity). In vitro, specifically inhibits alpha-3:beta-4 and alpha-7 nAChR currents in an allosteric manner (By similarity). Acts as a positive regulator of Wnt/beta-catenin signaling (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030548 acetylcholine receptor regulator activity;GO:0030550 acetylcholine receptor inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030425 dendrite", "go_biological_process": "GO:0007399 nervous system development;GO:0048167 regulation of synaptic plasticity;GO:0007601 visual perception;GO:0030182 neuron differentiation;GO:0090263 positive regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZTT2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A3K5-1", "uniprot_id": [ { "id": "H11_RAT", "url": "https://www.uniprot.org/uniprot/D4A3K5", "type": "external" } ], "mass": 22004.0, "length": 214, "protein_name": "Histone H1.1", "gene_name": "H1-1", "organism": "Rat", "refseq_name": "histone H1.1", "refseq_ac": [ { "id": "NP_001099583", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099583", "type": "external" } ], "gene_names_uniprotkb": "H1-1; Hist1h1a", "gene_names_refseq": "H1-1; H1f1; Hist1h1a", "protein_names_uniprotkb": "Histone H1.1; Histone H1a", "protein_names_refseq": "histone 1, H1a; histone H1.1; histone H1a; histone cluster 1 H1 family member a; histone cluster 1, H1a", "tax_id": 10116, "disease": "", "pathway": " (rno:291145); (R-RNO-140342); (R-RNO-2559584)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "15499382;22673903;24551219;29393594", "class_list": "", "function": "Binding of histone H1 to DNA is differentially modulated by redox state of HMGB1. Publication Status: Online-Only, [RefSeq, PubMed]; Histone H1 is both an anchoring protein and a substrate for activated PKCepsilon, [RefSeq, PubMed]; Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers and promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0003690 double-stranded DNA binding;GO:0031490 chromatin DNA binding;GO:0031492 nucleosomal DNA binding;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0009986 cell surface;GO:0031982 vesicle;GO:0000785 chromatin", "go_biological_process": "GO:0007283 spermatogenesis;GO:0006334 nucleosome assembly;GO:0048260 positive regulation of receptor-mediated endocytosis;GO:0030261 chromosome condensation;GO:0045910 negative regulation of DNA recombination", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "D4A3K5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88599-1", "uniprot_id": [ { "id": "MYBPH_RAT", "url": "https://www.uniprot.org/uniprot/O88599", "type": "external" } ], "mass": 52656.0, "length": 484, "protein_name": "Myosin-binding protein H", "gene_name": "Mybph", "organism": "Rat", "refseq_name": "myosin-binding protein H", "refseq_ac": [ { "id": "NP_114001", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114001", "type": "external" } ], "gene_names_uniprotkb": "Mybph", "gene_names_refseq": "Mybph", "protein_names_uniprotkb": "Myosin-binding protein H; H-protein; MyBP-H", "protein_names_refseq": "H-protein; myBP-H; myosin-binding protein H; norvegicus myosin binding protein H", "tax_id": 10116, "disease": "hypertension (Disease Ontology:DOID:10763); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (rno:83708)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "22673903;25449695;28800959;9868543", "class_list": "", "function": "Binds to myosin; probably involved in interaction with thick myofilaments in the A-band., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; PDGF-induced VSMC migration was inhibited by adenovirus-mediated expression of MYBPH whereas it was enhanced by small interfering RNA knockdown of MYBPH., [RefSeq, PubMed]; This study provides evidence for a potential role of MyBPH in hypertrophic cardiomyopathy., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008307 structural constituent of muscle", "go_cellular_component": "GO:0032982 myosin filament;GO:0031430 M band", "go_biological_process": "GO:0007155 cell adhesion;GO:0045214 sarcomere organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O88599-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02600-1", "uniprot_id": [ { "id": "MYL1_RAT", "url": "https://www.uniprot.org/uniprot/P02600", "type": "external" } ], "mass": 20680.0, "length": 189, "protein_name": "Myosin light chain 1/3, skeletal muscle isoform", "gene_name": "Myl1", "organism": "Rat", "refseq_name": "myosin light chain 1/3, skeletal muscle isoform isoform 1f", "refseq_ac": [ { "id": "NP_001071124", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071124", "type": "external" } ], "gene_names_uniprotkb": "Myl1", "gene_names_refseq": "MLC-f; MLC3-f; MLCf; Mcl3; Mlc1; Mlc3; Myl1", "protein_names_uniprotkb": "Myosin light chain 1/3, skeletal muscle isoform; MLC1/MLC3; MLC1F/MLC3F; Myosin light chain A1/A2; Myosin light chain alkali 1/2", "protein_names_refseq": "MLC1/MLC3; MLC1F/MLC3F; MLC1F; MLC3F; alkali myosin light chain 1; alkali myosin light chain 3; fast myosin alkali light chain 1; fast myosin alkali light chain 3; myosin light chain 1/3, skeletal muscle isoform isoform 1f; myosin light chain A1/A2; myosin light chain alkali 1/2; myosin, light polypeptide 1", "tax_id": 10116, "disease": "congenital myopathy 14 (Disease Ontology:DOID:0081346)", "pathway": " (rno:56781); (R-RNO-390522)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "17289664;17494635;20518849;22673903;23899007;3018505;30964931;6092382", "class_list": "", "function": "Mass spectrometry analysis of ischemic rat cardiomyocyte MLC1 showed nitration of tyrosines 78 and 190, [RefSeq, PubMed]; Metastasis of aggressive amoeboid sarcoma cells is dependent on Rho/ROCK/MLC signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Slowing of shortening velocity in tyep IIb fibers with hindlimb unloading involves a increase in the amount of MLC1-f., [RefSeq, PubMed]; These results indicate that rAd-MLC3f injection rescues hindlimb unloading-induced decline in Vo in MHC type IIB single muscle fibers. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P02601", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0008307 structural constituent of muscle;GO:0000146 microfilament motor activity", "go_cellular_component": "GO:0030016 myofibril;GO:0043292 contractile muscle fiber;GO:0016460 myosin II complex;GO:0016459 myosin complex", "go_biological_process": "GO:0006936 muscle contraction;GO:0060048 cardiac muscle contraction", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P02600-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06349-1", "uniprot_id": [ { "id": "H1T_RAT", "url": "https://www.uniprot.org/uniprot/P06349", "type": "external" } ], "mass": 21726.0, "length": 208, "protein_name": "Histone H1t", "gene_name": "H1-6", "organism": "Rat", "refseq_name": "histone H1t", "refseq_ac": [ { "id": "NP_036711", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036711", "type": "external" } ], "gene_names_uniprotkb": "H1-6; H1f6; H1ft; H1t", "gene_names_refseq": "H1-6; H1.3; H1D; H1f3; H1f6; H1ft; H1s-4; H1t; Hist1h1t", "protein_names_uniprotkb": "Histone H1t", "protein_names_refseq": "H1 histone family, member 3; H1 histone family, member T (testis-specific); histone 1 a family 3; histone 1, H1t; histone 1, family 3; histone 1t; histone H1t; histone cluster 1 H1 family member t; histone cluster 1, H1t; testis-specific histone 1, probably same as Hh1tts", "tax_id": 10116, "disease": "", "pathway": " (rno:24438)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17052712;1706721;18247329;19043117;22673903;2423516;3947637", "class_list": "", "function": "It appears that not the order of up-phosphorylation but the number of the phosphate groups is necessary for regulated chromatin decondensation, thus facilitating the substitution of H1t by transition proteins and protamines., [RefSeq, PubMed]; RFX2 and NF-Y binding to the testis-specific histone H1t promoter may be required for transcriptional activation in primary spermatocytes, [RefSeq, PubMed]; Testis-specific histone H1 that forms less compacted chromatin compared to other H1 histone subtypes. Formation of more relaxed chromatin may be required to promote chromatin architecture required for proper chromosome regulation during meiosis, such as homologous recombination. Histones H1 act as linkers that bind to nucleosomes and compact polynucleosomes into a higher-order chromatin configuration., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003690 double-stranded DNA binding;GO:0031492 nucleosomal DNA binding;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0006334 nucleosome assembly;GO:0030261 chromosome condensation;GO:0045910 negative regulation of DNA recombination", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P06349-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P60203-1", "uniprot_id": [ { "id": "MYPR_RAT", "url": "https://www.uniprot.org/uniprot/P60203", "type": "external" } ], "mass": 30077.0, "length": 277, "protein_name": "Myelin proteolipid protein", "gene_name": "Plp1", "organism": "Rat", "refseq_name": "myelin proteolipid protein", "refseq_ac": [ { "id": "NP_112252", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112252", "type": "external" } ], "gene_names_uniprotkb": "Plp1; Plp", "gene_names_refseq": "Plp1; Plp", "protein_names_uniprotkb": "Myelin proteolipid protein; Lipophilin; PLP", "protein_names_refseq": "Proteolipid protein (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated); lipophilin; myelin proteolipid protein; proteolipid protein (myelin) 1", "tax_id": 10116, "disease": "hereditary spastic paraplegia 2 (Disease Ontology:DOID:0110773); intellectual disability (Disease Ontology:DOID:1059); depressive disorder (Disease Ontology:DOID:1596); aortic valve stenosis (Disease Ontology:DOID:1712); epilepsy (Disease Ontology:DOID:1826); Pelizaeus-Merzbacher disease (Disease Ontology:DOID:3210)", "pathway": " (rno:24943)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "1689377;1702593;22673903;2410294;2414013;2468346;2479544;26002313;26563642;31885393", "class_list": "", "function": "All pups with exposure to methadone demonstrated decreased expression of PLP in the cerebral cortex and hippocampus.In the cerebellum, PLP expression was downregulated without apparent alteration of CNP and MBP expression. PLP and MBP expression, but not CNP expression, were significantly inhibited in the brainstem., [RefSeq, PubMed]; PLP and DM-20 mRNA expression is restricted to oligodendrocyte-lineage cells, [RefSeq, PubMed]; Protein levels of PLP were significantly greater in orbital frontal cortex (OFC) but not dorsal striatum (dSTR) of females as compared to males, suggesting that myelination is increased in OFC but similar in dSTR of females as compared to males, [RefSeq, PubMed]; This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P04400;P06905;Q561K5", "ec_number_list": [], "go_molecular_function": "GO:0019911 structural constituent of myelin sheath;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043209 myelin sheath;GO:0034683 integrin alphav-beta3 complex", "go_biological_process": "GO:0006954 inflammatory response;GO:0010628 positive regulation of gene expression;GO:0022010 central nervous system myelination;GO:0030335 positive regulation of cell migration;GO:0042552 myelination", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P60203-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q00729-1", "uniprot_id": [ { "id": "H2B1A_RAT", "url": "https://www.uniprot.org/uniprot/Q00729", "type": "external" } ], "mass": 14225.0, "length": 127, "protein_name": "Histone H2B type 1-A", "gene_name": "ENSRNOG00000064540; ENSRNOG00000068034; H2bc12; H2bc18; H2bc1; H2bc4; H2bc6; H2bcl2; H3c15; Hist1h2bq", "organism": "Rat", "refseq_name": "histone H2B type 1-A", "refseq_ac": [ { "id": "NP_072169", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_072169", "type": "external" } ], "gene_names_uniprotkb": "ENSRNOG00000064540; ENSRNOG00000068034; H2bc12; H2bc18; H2bc1; H2bc4; H2bc6; H2bcl2; H3c15; Hist1h2bq; ENSRNOG00000064540; ENSRNOG00000069233; H2bc12l1; H2bc12; H2bc18; H2bc21; H2bc27; H2bc3; H2bc4; H2bc6; H2bc8; H2bc9; H2bcl1; H2bcl2; H2bu1; H3c13; H3c15; H3c1; Hist1h2ba; Hist1h2bc; Hist1h2bg; Hist1h2bk; Hist1h2bo; Hist2h2be; Hist2h3c2; LOC100365043; LOC100910200; LOC100912338; LOC684797; Th2b", "gene_names_refseq": "H2bc1; Hist1h2ba; Th2b; histone", "protein_names_uniprotkb": "Histone H2B type 1-A; Histone H2B, testis; Testis-specific histone H2B", "protein_names_refseq": "histone 1, H2ba; histone H2B type 1-A; histone H2B, testis; histone cluster 1 H2B family member a; histone cluster 1, H2ba; testis-specific histone 2b; testis-specific histone H2B", "tax_id": 10116, "disease": "", "pathway": " (rno:100912338); (rno:24829); (rno:306945); (rno:310678); (rno:680312); (rno:680403); (R-RNO-110330); (R-RNO-110331); (R-RNO-212300); (R-RNO-2299718); (R-RNO-2559580); (R-RNO-2559582); (R-RNO-2559586); (R-RNO-3214815); (R-RNO-3214847); (R-RNO-427359); (R-RNO-427413); (R-RNO-5250924); (R-RNO-5578749); (R-RNO-5625886); (R-RNO-5693565); (R-RNO-5693571); (R-RNO-5693607); (R-RNO-606279); (R-RNO-68616); (R-RNO-69473); (R-RNO-73728); (R-RNO-73772); (R-RNO-8866654); (R-RNO-8936459); (R-RNO-9018519); (R-RNO-9764725); (R-RNO-9841922); (R-RNO-9843940); (R-RNO-9843970); (R-RNO-9909649); (R-RNO-9940951); (R-RNO-9943411); (R-RNO-9943962); (R-RNO-9970672)", "pathway_count": 40, "publication_count": 7, "publication_id_list": "16283522;19346237;2011515;25252820;2725487;31493790;3666307", "class_list": "", "function": "TH2BS11ph is predominantly associated with H3K4me3 positive genomic regions like gene promoters, etc. TH2BS11ph modification could act alone or in concert with other histone modifications to recruit the appropriate transcription or XY body recombination protein machinery at specific genomic loci. Publication Status: Online-Only, [RefSeq, PubMed]; Testis specific histone TH2B undergoes multiple post translational amino acid modification, suggesting the possibility of chromatin regulation., [RefSeq, PubMed]; Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells. Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q64677", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0042393 histone binding;GO:0030527 structural constituent of chromatin;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0009986 cell surface;GO:0000786 nucleosome;GO:0005615 extracellular space;GO:0070062 extracellular exosome", "go_biological_process": "GO:0006954 inflammatory response;GO:0006325 chromatin organization;GO:0006334 nucleosome assembly;GO:0031639 plasminogen activation;GO:0006337 nucleosome disassembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q00729-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P6R2-1", "uniprot_id": [ { "id": "DLDH_RAT", "url": "https://www.uniprot.org/uniprot/Q6P6R2", "type": "external" } ], "mass": 54038.0, "length": 509, "protein_name": "Dihydrolipoyl dehydrogenase, mitochondrial", "gene_name": "Dld", "organism": "Rat", "refseq_name": "dihydrolipoyl dehydrogenase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_955417", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955417", "type": "external" } ], "gene_names_uniprotkb": "Dld", "gene_names_refseq": "Dld", "protein_names_uniprotkb": "Dihydrolipoyl dehydrogenase, mitochondrial; 1.8.1.4; Dihydrolipoamide dehydrogenase", "protein_names_refseq": "dihydrolipoamide dehydrogenase (E3 component of pyruvate dehydrogenase complex, 2-oxo-glutarate complex, branched chain keto acid dehydrogenase complex); dihydrolipoyl dehydrogenase, mitochondrial precursor; dihydrolipoyl dehydrogenase, mitochondrial", "tax_id": 10116, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); dihydrolipoamide dehydrogenase deficiency (Disease Ontology:DOID:0061204)", "pathway": " (rno:298942); (R-RNO-204174); (R-RNO-5362517); (R-RNO-6783984); (R-RNO-70895); (R-RNO-9837999); (R-RNO-9853506); (R-RNO-9858328); (R-RNO-9859138); (R-RNO-9861559)", "pathway_count": 10, "publication_count": 8, "publication_id_list": "22673903;25981801;26446791;27213235;27888691;28178567;29393594;34502162", "class_list": "", "function": "DLD is down-regulation and related to steroid biosynthesis in Leyig cells exposed to heavy metals; cAMP/PKA act as downstream effector molecules of DLD, which activate phosphorylation of ERK1/2 to initiate the steroidogenesis., [RefSeq, PubMed]; Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched-chain amino acid-dehydrogenase complex). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A. In monomeric form may have additional moonlighting function as serine protease (By similarity). Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction (By similarity). The pyruvate dehydrogenase (PDH) complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links cytoplasmic glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and dihydrolipoamide dehydrogenase (E3). The E3 subunit catalyzes reoxidation of the dihydrolipoyl moiety on lipoyl-bearing domains (LBDs) of E2 with NAD+ as the ultimate electron acceptor (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; These results, together with the findings that the protein contents of DLDH, sirt3, and NQO1 all are decreased in the diabetic lung, demonstrate that redox imbalance, mitochondrial abnormality, and oxidative stress contribute to lung injury in diabetes., [RefSeq, PubMed]; This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. A similar protein in human, mouse, and pig has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In homodimeric form, the protein functions as a dehydrogenase and is found in several multi-enzyme complexes that regulate energy metabolism. However, as a monomer, the protein can function as a protease. [provided by RefSeq, Jan 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.3.43", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.43", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "2.3.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.12", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "1.2.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.4", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.61", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.61", "type": "external" }, { "id": "1.2.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.-", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "1.1.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.41", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" } ], "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0051287 NAD binding;GO:0004148 dihydrolipoyl dehydrogenase (NADH) activity;GO:0043544 lipoamide binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005929 cilium", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006103 2-oxoglutarate metabolic process;GO:0006508 proteolysis;GO:0042391 regulation of membrane potential;GO:0009083 branched-chain amino acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q6P6R2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ERC1-1", "uniprot_id": [ { "id": "MYO16_RAT", "url": "https://www.uniprot.org/uniprot/Q9ERC1", "type": "external" } ], "mass": 210691.0, "length": 1912, "protein_name": "Unconventional myosin-XVI", "gene_name": "Myo16", "organism": "Rat", "refseq_name": "unconventional myosin-XVI", "refseq_ac": [ { "id": "NP_620248", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620248", "type": "external" } ], "gene_names_uniprotkb": "Myo16; Myr8; Nyap3", "gene_names_refseq": "Myo16; Myr8", "protein_names_uniprotkb": "Unconventional myosin-XVI; Myosin heavy chain myr 8; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3; Unconventional myosin-16", "protein_names_refseq": "myosin heavy chain Myr 8; neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3; unconventional myosin-16; unconventional myosin-XVI", "tax_id": 10116, "disease": "", "pathway": " (rno:192253)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11588169;23596177", "class_list": "", "function": "Myo16 may play a regulatory role in cell cycle progression., [RefSeq, PubMed]; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). May be involved in targeting of the catalytic subunit of protein phosphatase 1 during brain development. Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9QXI0", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0044877 protein-containing complex binding;GO:0019903 protein phosphatase binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0016459 myosin complex", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0048812 neuron projection morphogenesis;GO:2000134 negative regulation of G1/S transition of mitotic cell cycle;GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0021549 cerebellum development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9ERC1-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88751-1", "uniprot_id": [ { "id": "CABP1_RAT", "url": "https://www.uniprot.org/uniprot/O88751", "type": "external" } ], "mass": 33017.0, "length": 298, "protein_name": "Calcium-binding protein 1", "gene_name": "Cabp1", "organism": "Rat", "refseq_name": "calcium-binding protein 1 isoform 2", "refseq_ac": [ { "id": "NP_001028847", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028847", "type": "external" } ], "gene_names_uniprotkb": "Cabp1", "gene_names_refseq": "Cabp1", "protein_names_uniprotkb": "Calcium-binding protein 1; CaBP1; Caldendrin", "protein_names_refseq": "calcium-binding protein 1 isoform 2; caldendrin", "tax_id": 10116, "disease": "temporal lobe epilepsy (Disease Ontology:DOID:3328); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:171051)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11865310;11906216;12032348;12860411;15095872;18303947;23650371;25058677;28437073;9694893", "class_list": "", "function": "Caldendrin exhibits very little change in surface hydrophobicity and secondary as well as tertiary structure upon Ca2+-binding to Mg2+-saturated protein. Publication Status: Online-Only, [RefSeq, PubMed]; Caldendrin is a neuronal calcium-binding protein. Two additional splice variants derive from the caldendrin gene, which have unrelated N-termini were identified in neurohypophyseal axons and on secretory granules of endocrine cells., [RefSeq, PubMed]; Data suggest that during the transition from the apo to the holo state, guided by the stepwise filling of Ca2+, caldendrin passes through distinct states and acquires a stable conformational state when only binding site EF3 (one of four EF-hand motifs) is occupied by Ca2+., [RefSeq, PubMed]; Enhances inactivation, causes a depolarizing shift in the voltage dependence of activation, and does not support Ca2+-dependent facilitation of Ca(v)2.1 channels, [RefSeq, PubMed]; Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling (By similarity). Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels (PubMed:11865310). Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but has an opposite effect on channel function. Suppresses the calcium-dependent inactivation of CACNA1D. Inhibits TRPC5 channels. Prevents NMDA receptor-induced cellular degeneration. Required for the normal transfer of light signals through the retina (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; That InsP3 attenuates cross-linking, whereas CaBP1 promotes it. We conclude that CaBP1 inhibits InsP3R activity by restricting the intersubunit movements that initiate gating., [RefSeq, PubMed]; The presence of caldendrin in the PSD of distinct synapses may have important implications for Ca2+-modulated processes of synaptic plasticity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q711K8;Q91WZ7", "ec_number_list": [], "go_molecular_function": "GO:0031800 type 3 metabotropic glutamate receptor binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0048306 calcium-dependent protein binding;GO:0005246 calcium channel regulator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005856 cytoskeleton", "go_biological_process": "GO:0098885 modification of postsynaptic actin cytoskeleton;GO:0048167 regulation of synaptic plasticity;GO:0007601 visual perception;GO:0042308 negative regulation of protein import into nucleus;GO:1901385 regulation of voltage-gated calcium channel activity", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O88751-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35439-1", "uniprot_id": [ { "id": "NMDZ1_RAT", "url": "https://www.uniprot.org/uniprot/P35439", "type": "external" } ], "mass": 105509.0, "length": 938, "protein_name": "Glutamate receptor ionotropic, NMDA 1", "gene_name": "Grin1", "organism": "Rat", "refseq_name": "glutamate receptor ionotropic, NMDA 1 isoform 1b precursor", "refseq_ac": [ { "id": "NP_001257531", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257531", "type": "external" } ], "gene_names_uniprotkb": "Grin1; Nmdar1", "gene_names_refseq": "GluN1; Grin1; NMDAR1; NR1", "protein_names_uniprotkb": "Glutamate receptor ionotropic, NMDA 1; GluN1; Glutamate [NMDA] receptor subunit zeta-1; N-methyl-D-aspartate receptor subunit NR1; NMD-R1", "protein_names_refseq": "N-methyl-D-aspartate glutamate receptor; N-methyl-D-aspartate receptor subunit NR1; NMD-R1; NMDA R1 receptor C1 cassette; glutamate [NMDA] receptor subunit zeta-1; glutamate receptor ionotropic, NMDA 1 isoform 1b precursor; glutamate receptor ionotropic, NMDA 1; glutamate receptor, ionotropic, N-methyl D-aspartate 1; neurotransmitter receptor", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); Warsaw breakage syndrome (Disease Ontology:DOID:0060535); autosomal dominant neurodevelopmental disorder with or without hyperkinetic movements and seizures (Disease Ontology:DOID:0070038); developmental and epileptic encephalopathy 101 (Disease Ontology:DOID:0070387); Alzheimer's disease (Disease Ontology:DOID:10652); opioid abuse (Disease Ontology:DOID:11206); sciatic neuropathy (Disease Ontology:DOID:11446); neurodegenerative disease (Disease Ontology:DOID:1289); cognitive disorder (Disease Ontology:DOID:1561); alcohol use disorder (Disease Ontology:DOID:1574); status epilepticus (Disease Ontology:DOID:1824); middle cerebral artery infarction (Disease Ontology:DOID:3525); cerebral infarction (Disease Ontology:DOID:3526); placental insufficiency (Disease Ontology:DOID:3891); schizophrenia (Disease Ontology:DOID:5419); vascular dementia (Disease Ontology:DOID:8725)", "pathway": " (rno:24408); (R-RNO-3928662); (R-RNO-438066); (R-RNO-5673001); (R-RNO-8849932); (R-RNO-9609736)", "pathway_count": 6, "publication_count": 64, "publication_id_list": "10436042;10643790;10648644;11158244;11160393;11588171;11823786;11929923;12391275;12435416;12457264;12805203;1350383;1352681;1386026;1388270;15081590;15174082;15233747;15312654;15312791;15379998;15748156;15936117;15996549;16281028;16300895;16495444;16571972;16630835;16772733;18177891;1834949;18437031;18849881;20074623;20667449;21038693;21170295;21389213;22673903;23251573;23372792;24090084;24184018;24876489;26041915;26289587;26912815;27135925;27458189;27618671;27771532;28384476;28468946;31495080;36341805;37523044;38843836;39085540;7684237;8399301;8428958;9463421", "class_list": "", "function": "Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:1350383, PubMed:1388270, PubMed:1834949, PubMed:8428958). NMDARs participate in synaptic plasticity for learning and memory formation by contributing to the long-term potentiation (LTP) (By similarity). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:11823786, PubMed:1350383, PubMed:1388270, PubMed:15996549, PubMed:18177891, PubMed:1834949, PubMed:24876489, PubMed:27135925, PubMed:27618671, PubMed:28384476, PubMed:28468946, PubMed:8428958). NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium (By similarity). Each GluN2 or GluN3 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (PubMed:10436042, PubMed:11160393, PubMed:11929923, PubMed:28384476, PubMed:9463421). Forms excitatory glycinergic receptor complexes with GluN3 alone which are activated by glycine binding to the GluN1 and GluN3 subunits (PubMed:11823786, PubMed:11929923, PubMed:12391275)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Molecular mechanism of ligand gating and opening of NMDA receptor., [RefSeq, PubMed]; Reduced Expression of the Htr2a, Grin1, and Bdnf Genes and Cognitive Inflexibility in a Model of High Compulsive Rats., [RefSeq, PubMed]; The pathogenic N650K variant in the GluN1 subunit regulates the trafficking, conductance, and pharmacological properties of NMDA receptors., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 12, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 12, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 12, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 7, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 15, "disease_count": 16, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "Q62646", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0022849 glutamate-gated calcium ion channel activity;GO:0022824 transmitter-gated monoatomic ion channel activity;GO:0005102 signaling receptor binding;GO:0005262 calcium channel activity;GO:0005516 calmodulin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0017146 NMDA selective glutamate receptor complex;GO:0048787 presynaptic active zone membrane;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0060179 male mating behavior;GO:0001964 startle response;GO:1903539 protein localization to postsynaptic membrane;GO:0001967 suckling behavior", "synthesized_glycan_count": 0, "hit_score": 9.3, "record_id": "P35439-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91Y77-1", "uniprot_id": [ { "id": "MOT10_RAT", "url": "https://www.uniprot.org/uniprot/Q91Y77", "type": "external" } ], "mass": 55678.0, "length": 514, "protein_name": "Monocarboxylate transporter 10", "gene_name": "Slc16a10", "organism": "Rat", "refseq_name": "monocarboxylate transporter 10", "refseq_ac": [ { "id": "NP_620186", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620186", "type": "external" } ], "gene_names_uniprotkb": "Slc16a10; Mct10; Tat1", "gene_names_refseq": "Slc16a10; Tat1", "protein_names_uniprotkb": "Monocarboxylate transporter 10; Aromatic amino acid transporter 1; MCT 10; Solute carrier family 16 member 10; T-type amino acid transporter 1", "protein_names_refseq": "MCT 10; T-type amino acid transporter 1; aromatic amino acid transporter 1; monocarboxylate transporter 10; solute carrier family 16 (aromatic amino acid transporter), member 10; solute carrier family 16 (monocarboxylic acid transporters), member 10; solute carrier family 16, member 10 (aromatic amino acid transporter)", "tax_id": 10116, "disease": "esophagus squamous cell carcinoma (Disease Ontology:DOID:3748)", "pathway": " (rno:170566); (R-RNO-352230)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "11278508;22673903", "class_list": "", "function": "Sodium- and proton-independent thyroid hormones and aromatic acids transporter. Mediates both uptake and efflux of 3,5,3'-triiodothyronine (T3) and 3,5,3',5'-tetraiodothyronine (T4) with high affinity, suggesting a role in the homeostasis of thyroid hormone levels (By similarity). Responsible for low affinity bidirectional transport of the aromatic amino acids, such as phenylalanine, tyrosine, tryptophan and L-3,4-dihydroxyphenylalanine (L-dopa) (PubMed:11278508). Plays an important role in homeostasis of aromatic amino acids (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3V621", "ec_number_list": [], "go_molecular_function": "GO:0015196 L-tryptophan transmembrane transporter activity;GO:0022857 transmembrane transporter activity;GO:0015173 aromatic amino acid transmembrane transporter activity;GO:0015349 thyroid hormone transmembrane transporter activity;GO:0005302 L-tyrosine transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0030054 cell junction", "go_biological_process": "GO:0006590 thyroid hormone generation;GO:0070460 thyroid-stimulating hormone secretion;GO:0015801 aromatic amino acid transport;GO:0070327 thyroid hormone transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q91Y77-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O55012-1", "uniprot_id": [ { "id": "PICAL_RAT", "url": "https://www.uniprot.org/uniprot/O55012", "type": "external" } ], "mass": 69286.0, "length": 640, "protein_name": "Phosphatidylinositol-binding clathrin assembly protein", "gene_name": "Picalm", "organism": "Rat", "refseq_name": "phosphatidylinositol-binding clathrin assembly protein isoform 9", "refseq_ac": [ { "id": "NP_446006", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446006", "type": "external" } ], "gene_names_uniprotkb": "Picalm; Calm", "gene_names_refseq": "Calm; Picalm", "protein_names_uniprotkb": "Phosphatidylinositol-binding clathrin assembly protein; Clathrin assembly lymphoid myeloid leukemia protein; rCALM", "protein_names_refseq": "clathrin-assembly lymphoid leukemia protein; clathrin-assembly lymphoid myeloid leukemia protein; phosphatidylinositol-binding clathrin assembly protein isoform 9; rCALM", "tax_id": 10116, "disease": "acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (rno:89816); (R-RNO-432722); (R-RNO-8856825); (R-RNO-8856828); (R-RNO-9696264)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "10630373;11161218;11190274;17496889;18683930;19322778;38843836", "class_list": "", "function": "Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly. Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature. In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8. In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors. Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O55011", "ec_number_list": [], "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0017124 SH3 domain binding;GO:0042802 identical protein binding;GO:0050750 low-density lipoprotein particle receptor binding;GO:0048156 tau protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005768 endosome;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0046579 positive regulation of Ras protein signal transduction;GO:1903861 positive regulation of dendrite extension;GO:0097753 membrane bending;GO:0051223 regulation of protein transport;GO:1900244 positive regulation of synaptic vesicle endocytosis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O55012-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06911-1", "uniprot_id": [ { "id": "LCN5_RAT", "url": "https://www.uniprot.org/uniprot/P06911", "type": "external" } ], "mass": 20670.0, "length": 188, "protein_name": "Epididymal-specific lipocalin-5", "gene_name": "Lcn5", "organism": "Rat", "refseq_name": "epididymal-specific lipocalin-5 precursor", "refseq_ac": [ { "id": "NP_077050", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077050", "type": "external" } ], "gene_names_uniprotkb": "Lcn5; Erabp", "gene_names_refseq": "Erabp; Lcn5", "protein_names_uniprotkb": "Epididymal-specific lipocalin-5; Androgen-dependent epididymal 18.5 kDa protein; E-RABP; ESP-I; Epididymal retinoic acid-binding protein; Epididymal secretory protein I", "protein_names_refseq": "E-RABP; ESP-I; androgen-dependent epididymal 18.5 kDa protein; epididymal retinoic acid-binding protein; epididymal secretory protein I; epididymal-specific lipocalin-5 precursor; epididymal-specific lipocalin-5", "tax_id": 10116, "disease": "", "pathway": " (rno:29552)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "1731756;2125511;2165489;2420796;8069623", "class_list": "", "function": "Associates with spermatozoa in the epididymal fluid but does not bind tightly to them. Binds both all-trans and 9-cis retinoic acid. May act as a retinoid carrier protein which is required for epididymal function and/or sperm maturation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0036094 small molecule binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P06911-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07009-1", "uniprot_id": [ { "id": "CAN2_RAT", "url": "https://www.uniprot.org/uniprot/Q07009", "type": "external" } ], "mass": 79919.0, "length": 700, "protein_name": "Calpain-2 catalytic subunit", "gene_name": "Capn2", "organism": "Rat", "refseq_name": "calpain-2 catalytic subunit", "refseq_ac": [ { "id": "NP_058812", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058812", "type": "external" } ], "gene_names_uniprotkb": "Capn2", "gene_names_refseq": "Capn2", "protein_names_uniprotkb": "Calpain-2 catalytic subunit; 3.4.22.53; CANP 2; Calcium-activated neutral proteinase 2; Calpain M-type; Calpain-2 large subunit; M-calpain; Millimolar-calpain", "protein_names_refseq": "CANP 2; M-calpain; calcium-activated neutral proteinase 2; calpain 2, (m/II) large subunit; calpain II; calpain M-type; calpain-2 catalytic subunit; calpain-2 large subunit; millimolar-calpain", "tax_id": 10116, "disease": "traumatic brain injury (Disease Ontology:DOID:0081292); hereditary spastic paraplegia 76 (Disease Ontology:DOID:0110821); intellectual disability (Disease Ontology:DOID:1059); Alzheimer's disease (Disease Ontology:DOID:10652); sciatic neuropathy (Disease Ontology:DOID:11446); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); hereditary spastic paraplegia (Disease Ontology:DOID:2476); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:29154); (R-RNO-1474228); (R-RNO-9856530); (R-RNO-9860927)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "10601010;11102442;11342050;19020622;19020623;24806345;33517223;33688783;34513987;36430329;36703913;7635186;8218419", "class_list": "", "function": "Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226'. Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs., [UniProtKB, UniProtKB, UniProtKB]; Calpain-2 Facilitates Autophagic/Lysosomal Defects and Apoptosis in ARPE-19 Cells and Rats Induced by Exosomes from RPE Cells under NaIO3 Stimulation. Publication Status: Online-Only, [RefSeq, PubMed]; Inhibition of Calpain Attenuates Degeneration of Substantia Nigra Neurons in the Rotenone Rat Model of Parkinson's Disease. Publication Status: Online-Only, [RefSeq, PubMed]; Inhibition of extracellular signal-regulated kinase/calpain-2 pathway reduces neuroinflammation and necroptosis after cerebral ischemia-reperfusion injury in a rat model of cardiac arrest., [RefSeq, PubMed]; M-Calpain is released from striatal synaptosomes., [RefSeq, PubMed]; MicroRNA-137 Inhibited Hypoxia-Induced Proliferation of Pulmonary Artery Smooth Muscle Cells by Targeting Calpain-2. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 13, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" }, { "id": "3.4.22.54", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.54", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.22.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.53", "type": "external" } ], "go_molecular_function": "GO:0004198 calcium-dependent cysteine-type endopeptidase activity;GO:0019899 enzyme binding;GO:0005509 calcium ion binding;GO:0044877 protein-containing complex binding;GO:0008092 cytoskeletal protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0001666 response to hypoxia;GO:0042542 response to hydrogen peroxide;GO:0071222 cellular response to lipopolysaccharide;GO:0007565 female pregnancy", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q07009-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99PV3-1", "uniprot_id": [ { "id": "MKLN1_RAT", "url": "https://www.uniprot.org/uniprot/Q99PV3", "type": "external" } ], "mass": 84834.0, "length": 735, "protein_name": "Muskelin", "gene_name": "Mkln1", "organism": "Rat", "refseq_name": "muskelin isoform 1", "refseq_ac": [ { "id": "NP_112649", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112649", "type": "external" } ], "gene_names_uniprotkb": "Mkln1; Msk", "gene_names_refseq": "Mkln1", "protein_names_uniprotkb": "Muskelin", "protein_names_refseq": "muskelin 1, intracellular mediator containing kelch motifs; muskelin isoform 1", "tax_id": 10116, "disease": "", "pathway": " (rno:83536); (R-RNO-9861718)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "11006128;21482357;25579817", "class_list": "", "function": "Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (By similarity). Required for internalization of the GABA receptor GABRA1 from the cell membrane via endosomes and subsequent GABRA1 degradation (PubMed:25579817). Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1 (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005938 cell cortex", "go_biological_process": "GO:0007160 cell-matrix adhesion;GO:0030036 actin cytoskeleton organization;GO:0008360 regulation of cell shape;GO:0002090 regulation of receptor internalization;GO:0098968 neurotransmitter receptor transport postsynaptic membrane to endosome", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q99PV3-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66HC5-1", "uniprot_id": [ { "id": "NUP93_RAT", "url": "https://www.uniprot.org/uniprot/Q66HC5", "type": "external" } ], "mass": 93302.0, "length": 819, "protein_name": "Nuclear pore complex protein Nup93", "gene_name": "Nup93", "organism": "Rat", "refseq_name": "nuclear pore complex protein Nup93", "refseq_ac": [ { "id": "NP_001011925", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011925", "type": "external" } ], "gene_names_uniprotkb": "Nup93", "gene_names_refseq": "Nup93", "protein_names_uniprotkb": "Nuclear pore complex protein Nup93; 93 kDa nucleoporin; Nucleoporin Nup93", "protein_names_refseq": "93 kDa nucleoporin; nuclear pore complex protein Nup93; nucleoporin 93kDa; nucleoporin Nup93", "tax_id": 10116, "disease": "nephrotic syndrome type 12 (Disease Ontology:DOID:0080387)", "pathway": " (rno:291874); (R-RNO-159227); (R-RNO-159230); (R-RNO-159231); (R-RNO-159236); (R-RNO-170822); (R-RNO-1855170); (R-RNO-1855196); (R-RNO-1855229); (R-RNO-191859); (R-RNO-3108214); (R-RNO-3232142); (R-RNO-3301854); (R-RNO-3371453); (R-RNO-4085377); (R-RNO-4551638); (R-RNO-4570464); (R-RNO-4615885); (R-RNO-9615933)", "pathway_count": 19, "publication_count": 2, "publication_id_list": "15703211;36807413", "class_list": "", "function": "Downregulation of NUP93 aggravates hypoxia-induced death of cardiomyocytes in vitro through abnormal regulation of gene transcription., [RefSeq, PubMed]; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005813 centrosome;GO:0031965 nuclear membrane;GO:0034399 nuclear periphery", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0006998 nuclear envelope organization;GO:0051292 nuclear pore complex assembly;GO:0060391 positive regulation of SMAD protein signal transduction;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q66HC5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IFU8-1", "uniprot_id": [ { "id": "K1C17_RAT", "url": "https://www.uniprot.org/uniprot/Q6IFU8", "type": "external" } ], "mass": 48123.0, "length": 433, "protein_name": "Keratin, type I cytoskeletal 17", "gene_name": "Krt15; Krt17", "organism": "Rat", "refseq_name": "keratin, type I cytoskeletal 17", "refseq_ac": [ { "id": "NP_997710", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997710", "type": "external" } ], "gene_names_uniprotkb": "Krt15; Krt17; Ka17; Krt15", "gene_names_refseq": "Ka17; Krt17", "protein_names_uniprotkb": "Keratin, type I cytoskeletal 17; CK-17; Cytokeratin-17; K17; Keratin-17; Type I keratin Ka17", "protein_names_refseq": "CK-17; K17; cytokeratin-17; keratin 17, type I; keratin, type I cytoskeletal 17; type I keratin KA17", "tax_id": 10116, "disease": "pachyonychia congenita (Disease Ontology:DOID:0050449); steatocystoma multiplex (Disease Ontology:DOID:0111556); ectodermal dysplasia (Disease Ontology:DOID:2121)", "pathway": " (rno:287702); (R-RNO-6805567); (R-RNO-6809371)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "15085952;22673903;34502162", "class_list": "", "function": "Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial 'stem cells'. Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0030280 structural constituent of skin epidermis;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005882 intermediate filament;GO:0071944 cell periphery;GO:0045111 intermediate filament cytoskeleton", "go_biological_process": "GO:0030307 positive regulation of cell growth;GO:0030855 epithelial cell differentiation;GO:0031424 keratinization;GO:0045727 positive regulation of translation;GO:0045109 intermediate filament organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6IFU8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ESN0-1", "uniprot_id": [ { "id": "NIBA1_RAT", "url": "https://www.uniprot.org/uniprot/Q9ESN0", "type": "external" } ], "mass": 103465.0, "length": 937, "protein_name": "Protein Niban 1", "gene_name": "Niban1", "organism": "Rat", "refseq_name": "protein Niban 1", "refseq_ac": [ { "id": "NP_071578", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071578", "type": "external" } ], "gene_names_uniprotkb": "Niban1; Fam129a; Niban", "gene_names_refseq": "Fam129a; Niban1; Niban", "protein_names_uniprotkb": "Protein Niban 1; Protein FAM129A; Protein Niban", "protein_names_refseq": "family with sequence similarity 129, member A; protein Niban 1", "tax_id": 10116, "disease": "", "pathway": " (rno:63912)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11011112;14990989;17588536;22673903;29393594", "class_list": "", "function": "Regulates phosphorylation of a number of proteins involved in translation regulation including EIF2A, EIF4EBP1 and RPS6KB1. May be involved in the endoplasmic reticulum stress response (By similarity)., [UniProtKB, UniProtKB]; Together these results suggest that Niban is involved in the ER stress response, and that Niban can modulate cell death signaling by regulating translation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0001933 negative regulation of protein phosphorylation;GO:0045727 positive regulation of translation;GO:0034976 response to endoplasmic reticulum stress", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9ESN0-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35240-1", "uniprot_id": [ { "id": "ASIC3_RAT", "url": "https://www.uniprot.org/uniprot/O35240", "type": "external" } ], "mass": 59227.0, "length": 533, "protein_name": "Acid-sensing ion channel 3", "gene_name": "Asic3", "organism": "Rat", "refseq_name": "acid-sensing ion channel 3", "refseq_ac": [ { "id": "NP_775158", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775158", "type": "external" } ], "gene_names_uniprotkb": "Asic3; Accn3; Drasic", "gene_names_refseq": "Accn3; Asic3", "protein_names_uniprotkb": "Acid-sensing ion channel 3; ASIC3; Amiloride-sensitive cation channel 3; DRASIC; Dorsal root ASIC", "protein_names_refseq": "DRASIC; acid-sensing (proton-gated) ion channel 3; acid-sensing ion channel 3; amiloride-sensitive cation channel 3; dorsal root ASIC; proton gated cation channel DRASIC", "tax_id": 10116, "disease": "", "pathway": " (rno:286920); (R-RNO-2672351)", "pathway_count": 2, "publication_count": 24, "publication_id_list": "10187795;10842183;11120882;11528414;11587714;11588175;11842212;12486159;12526774;12668052;14522957;14976185;15044953;15317815;22850675;28396446;32887365;33280501;34088898;34918385;37604935;9261094;9368048;9707631", "class_list": "", "function": "ASIC3 inhibition modulates inflammation-induced changes in the activity and sensitivity of Adelta and C fiber sensory neurons that innervate bone., [RefSeq, PubMed]; Forms pH-gated heterotrimeric sodium channels that act as postsynaptic excitatory receptors in the nervous system (PubMed:10842183, PubMed:11120882, PubMed:11587714, PubMed:9261094). Upon extracellular acidification, these channels generate a biphasic current with a fast inactivating and a slow sustained phase (PubMed:10842183, PubMed:11120882). ASIC3 is more sensitive to protons and gates between closed, open, and desensitized states faster than other ASICs (PubMed:11120882). Displays high selectivity for sodium ions but can also permit the permeation of other cations (PubMed:10842183, PubMed:11120882). As a neuronal acid sensor, probably contributes to mechanoreception, acid nociception, and heat nociception (By similarity). By forming heterotrimeric channels with ASIC2, generates a biphasic current with a fast inactivating and a slow sustained phase, which in sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissues (PubMed:10842183, PubMed:11120882, PubMed:28396446, PubMed:9368048)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Histidine Residues Are Responsible for Bidirectional Effects of Zinc on Acid-Sensing Ion Channel 1a/3 Heteromeric Channels. Publication Status: Online-Only, [RefSeq, PubMed]; Retrograde nerve growth factor signaling modulates tooth mechanical hyperalgesia induced by orthodontic tooth movement via acid-sensing ion channel 3. Publication Status: Online-Only, [RefSeq, PubMed]; Upregulation of acid sensing ion channels is associated with esophageal hypersensitivity in GERD., [RefSeq, PubMed]; Vacuolar-ATPase-mediated muscle acidification caused muscular mechanical nociceptive hypersensitivity after chronic stress in rats, which involved extracellular matrix proteoglycan and ASIC3. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0015280 ligand-gated sodium channel activity;GO:0022839 monoatomic ion-gated channel activity;GO:0005261 monoatomic cation channel activity;GO:0160128 pH-gated monoatomic ion channel activity;GO:0160125 pH-gated sodium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0050907 detection of chemical stimulus involved in sensory perception;GO:0034220 monoatomic ion transmembrane transport;GO:0050965 detection of temperature stimulus involved in sensory perception of pain;GO:0051899 membrane depolarization;GO:0009612 response to mechanical stimulus", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "O35240-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JLU4-1", "uniprot_id": [ { "id": "SHAN3_RAT", "url": "https://www.uniprot.org/uniprot/Q9JLU4", "type": "external" } ], "mass": 186376.0, "length": 1740, "protein_name": "SH3 and multiple ankyrin repeat domains protein 3", "gene_name": "Shank3", "organism": "Rat", "refseq_name": "SH3 and multiple ankyrin repeat domains protein 3", "refseq_ac": [ { "id": "NP_067708", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067708", "type": "external" } ], "gene_names_uniprotkb": "Shank3; Prosap2", "gene_names_refseq": "Prosap2; Shank3; Spank-2", "protein_names_uniprotkb": "SH3 and multiple ankyrin repeat domains protein 3; ProSAP2; Proline-rich synapse-associated protein 2; SPANK-2; Shank3", "protein_names_refseq": "SH3 and multiple ankyrin repeat domains protein 3; SH3/ankyrin domain gene 3; Shank postsynaptic density protein 3a; proline-rich synapse-associated protein 2", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); schizophrenia 15 (Disease Ontology:DOID:0070091); Phelan-McDermid syndrome (Disease Ontology:DOID:0080354); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:59312); (R-RNO-6794361); (R-RNO-8853659)", "pathway_count": 3, "publication_count": 20, "publication_id_list": "10433268;10433269;10527873;10806096;10958799;15014124;16439662;16522626;17304222;21606927;21795692;22673903;23100419;23897824;24089484;33203459;33945465;34313403;35471151;37392026", "class_list": "", "function": "A bidirectional switch in the Shank3 phosphorylation state biases synapses toward up- or downscaling. Publication Status: Online-Only, [RefSeq, PubMed]; Altered synaptic ultrastructure in the prefrontal cortex of Shank3-deficient rats. Publication Status: Online-Only, [RefSeq, PubMed]; Autism-associated SHANK3 missense point mutations impact conformational fluctuations and protein turnover at synapses. Publication Status: Online-Only, [RefSeq, PubMed]; Clustering of CaV 1.3 L-type calcium channels by Shank3., [RefSeq, PubMed]; Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Reduced brain volume and white matter alterations in Shank3-deficient rats., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 30, "reported_mutagensis": 11, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9WUY7;Q9WV47", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0008270 zinc ion binding;GO:0017124 SH3 domain binding;GO:0042802 identical protein binding;GO:0001664 G protein-coupled receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0043197 dendritic spine", "go_biological_process": "GO:0097107 postsynaptic density assembly;GO:1900452 regulation of long-term synaptic depression;GO:0097117 guanylate kinase-associated protein clustering;GO:1904717 regulation of AMPA glutamate receptor clustering;GO:0050975 sensory perception of touch", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q9JLU4-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RKI6-1", "uniprot_id": [ { "id": "EIF1A_RAT", "url": "https://www.uniprot.org/uniprot/Q5RKI6", "type": "external" } ], "mass": 19076.0, "length": 167, "protein_name": "Probable RNA-binding protein EIF1AD", "gene_name": "Eif1ad", "organism": "Rat", "refseq_name": "probable RNA-binding protein EIF1AD", "refseq_ac": [ { "id": "NP_001008306", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008306", "type": "external" } ], "gene_names_uniprotkb": "Eif1ad", "gene_names_refseq": "Eif1ad; RGD1304686", "protein_names_uniprotkb": "Probable RNA-binding protein EIF1AD; Eukaryotic translation initiation factor 1A domain-containing protein", "protein_names_refseq": "eukaryotic translation initiation factor 1A domain-containing protein; probable RNA-binding protein EIF1AD", "tax_id": 10116, "disease": "", "pathway": " (rno:293673)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Plays a role into cellular response to oxidative stress. Decreases cell proliferation (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5RKI6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02563-1", "uniprot_id": [ { "id": "MYH6_RAT", "url": "https://www.uniprot.org/uniprot/P02563", "type": "external" } ], "mass": 223508.0, "length": 1938, "protein_name": "Myosin-6", "gene_name": "Myh6", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Myh6", "gene_names_refseq": "", "protein_names_uniprotkb": "Myosin-6; MyHC-alpha; Myosin heavy chain 6; Myosin heavy chain, cardiac muscle alpha isoform", "protein_names_refseq": "", "tax_id": 10116, "disease": "distal arthrogryposis (Disease Ontology:DOID:0050646); cardiomyopathy (Disease Ontology:DOID:0050700); familial hypertrophic cardiomyopathy (Disease Ontology:DOID:0080326); congenital myopathy 6 (Disease Ontology:DOID:0080719); spondylocarpotarsal synostosis syndrome (Disease Ontology:DOID:0090116); atrial heart septal defect 3 (Disease Ontology:DOID:0110108); hypertrophic cardiomyopathy 1 (Disease Ontology:DOID:0110307); hypertrophic cardiomyopathy 14 (Disease Ontology:DOID:0110320); dilated cardiomyopathy 1EE (Disease Ontology:DOID:0110453); dilated cardiomyopathy 1S (Disease Ontology:DOID:0110454); autosomal dominant hyaline body myopathy (Disease Ontology:DOID:0111269); distal arthrogryposis type 1 (Disease Ontology:DOID:0111596); distal arthrogryposis type 2B3 (Disease Ontology:DOID:0111602); distal arthrogryposis type 2A (Disease Ontology:DOID:0111605); distal myopathy (Disease Ontology:DOID:11720); dilated cardiomyopathy (Disease Ontology:DOID:12930); sick sinus syndrome (Disease Ontology:DOID:13884); hypothyroidism (Disease Ontology:DOID:1459); atrial heart septal defect (Disease Ontology:DOID:1882); myotonia congenita (Disease Ontology:DOID:2106); inclusion body myositis (Disease Ontology:DOID:3429); Wolff-Parkinson-White syndrome (Disease Ontology:DOID:384); restrictive cardiomyopathy (Disease Ontology:DOID:397); myopathy (Disease Ontology:DOID:423); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (R-RNO-390522)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "18988896;19322778;22673903;26109417;2614840;2798111;34502162;6241892;6585819;7045682", "class_list": "", "function": "Muscle contraction., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 47, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 47, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 47, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 26, "glyco_site_count": 46, "binding_glycan_count": 0, "secondary_ac_list": "Q63351", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005859 muscle myosin complex;GO:0005737 cytoplasm;GO:0001725 stress fiber;GO:0032982 myosin filament;GO:0030018 Z disc", "go_biological_process": "GO:0031449 regulation of slow-twitch skeletal muscle fiber contraction;GO:1904385 cellular response to angiotensin;GO:0060420 regulation of heart growth;GO:0001701 in utero embryonic development;GO:0003009 skeletal muscle contraction", "synthesized_glycan_count": 0, "hit_score": 5.9, "record_id": "P02563-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48966-1", "uniprot_id": [ { "id": "MPIP2_RAT", "url": "https://www.uniprot.org/uniprot/P48966", "type": "external" } ], "mass": 64287.0, "length": 574, "protein_name": "M-phase inducer phosphatase 2", "gene_name": "Cdc25b", "organism": "Rat", "refseq_name": "M-phase inducer phosphatase 2 isoform 1", "refseq_ac": [ { "id": "NP_598256", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598256", "type": "external" } ], "gene_names_uniprotkb": "Cdc25b", "gene_names_refseq": "Cdc25b", "protein_names_uniprotkb": "M-phase inducer phosphatase 2; 3.1.3.48; Dual specificity phosphatase Cdc25B", "protein_names_refseq": "M-phase inducer phosphatase 2 isoform 1; M-phase inducer phosphatase 2; dual specificity phosphatase Cdc25B", "tax_id": 10116, "disease": "endometrial hyperplasia (Disease Ontology:DOID:0080365); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); endometrial cancer (Disease Ontology:DOID:1380); vulva squamous cell carcinoma (Disease Ontology:DOID:2101); breast carcinoma (Disease Ontology:DOID:3459)", "pathway": " (rno:171103); (R-RNO-69273); (R-RNO-69656)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "22673903;8156993", "class_list": "", "function": "Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. The three isoforms seem to have a different level of activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" } ], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0004721 phosphoprotein phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0007144 female meiosis I;GO:0006468 protein phosphorylation;GO:0010971 positive regulation of G2/M transition of mitotic cell cycle;GO:0045931 positive regulation of mitotic cell cycle;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P48966-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q78PB6-1", "uniprot_id": [ { "id": "NDEL1_RAT", "url": "https://www.uniprot.org/uniprot/Q78PB6", "type": "external" } ], "mass": 38366.0, "length": 345, "protein_name": "Nuclear distribution protein nudE-like 1", "gene_name": "Ndel1", "organism": "Rat", "refseq_name": "nuclear distribution protein nudE-like 1", "refseq_ac": [ { "id": "NP_579854", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_579854", "type": "external" } ], "gene_names_uniprotkb": "Ndel1; Nude2; Nudel", "gene_names_refseq": "EOPA; NUDE2; Ndel1; Nudel", "protein_names_uniprotkb": "Nuclear distribution protein nudE-like 1; Protein Nudel", "protein_names_refseq": "LIS1-interacting protein NUDEL; endooligopeptidase A; nuclear distribution gene E-like homolog 1; nuclear distribution protein nudE-like 1; nudE nuclear distribution gene E homolog like 1; protein Nudel", "tax_id": 10116, "disease": "lissencephaly (Disease Ontology:DOID:0050453); epilepsy (Disease Ontology:DOID:1826); Rubinstein-Taybi syndrome (Disease Ontology:DOID:1933); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:170845); (R-RNO-141430); (R-RNO-141444); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-5663220); (R-RNO-68877); (R-RNO-9648025)", "pathway_count": 8, "publication_count": 6, "publication_id_list": "11163260;15728732;17035248;21890215;22673903;23551859", "class_list": "", "function": "Knocking down both Ndel1 and NudCL almost blocked retrograde mitochondrial axonal transport. Erratum:[Traffic. 2013 Oct;14(10):1105-8], [RefSeq, PubMed]; Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). Plays a role, together with DISC1, in the regulation of neurite outgrowth. May act as a RAB9A/B effector that tethers RAB9-associated late endosomes to the dynein motor for their retrograde transport to the trans-Golgi network (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; The results did not detect a significant association. It indicated that common genetic variations in NDEL1 genes might not play a role in the genetic predisposition to autism., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6IRI4", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0048487 beta-tubulin binding;GO:0043014 alpha-tubulin binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005813 centrosome;GO:0005819 spindle;GO:0005874 microtubule;GO:0030424 axon", "go_biological_process": "GO:0048680 positive regulation of axon regeneration;GO:0021799 cerebral cortex radially oriented cell migration;GO:0008090 retrograde axonal transport;GO:0007059 chromosome segregation;GO:0016477 cell migration", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q78PB6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1Z9-1", "uniprot_id": [ { "id": "PDLI7_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z1Z9", "type": "external" } ], "mass": 49913.0, "length": 457, "protein_name": "PDZ and LIM domain protein 7", "gene_name": "Pdlim7", "organism": "Rat", "refseq_name": "PDZ and LIM domain protein 7 isoform 1", "refseq_ac": [ { "id": "NP_775148", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775148", "type": "external" } ], "gene_names_uniprotkb": "Pdlim7; Enigma; Lim1", "gene_names_refseq": "Enigma; Pdlim7", "protein_names_uniprotkb": "PDZ and LIM domain protein 7; LIM mineralization protein; LMP; Protein enigma", "protein_names_refseq": "LIM mineralization protein 2; LMP; PDZ and LIM domain protein 7 isoform 1; PDZ and LIM domain protein 7; enigma (LIM domain protein); protein enigma", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); myofibrillar myopathy 4 (Disease Ontology:DOID:0080095); myopathy (Disease Ontology:DOID:423)", "pathway": " (rno:286908); (R-RNO-8853659)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "15219810;17496889;17964547;19322778;19900557;22673903;25677945;9832452", "class_list": "", "function": "Findings describe a positive regulatory effect of LMP-1 on BMP-2 expression and BMP-2-mediated osteogenesis. This effect occurs through activation of ERK1/2 pathway and subsequent upregulation of Runx2 transactivity., [RefSeq, PubMed]; In rats, estrogen was found to up-regulate enigma(LIM domain protein) genes in smooth muscle vascular cells., [RefSeq, PubMed]; May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway., [UniProtKB, PubMed]; These findings indicate that CLP36 plays a critical role in stress fiber formation and the assembly of focal adhesions in BeWo cells., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051371 muscle alpha-actinin binding;GO:0003779 actin binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005912 adherens junction;GO:0005925 focal adhesion;GO:0015629 actin cytoskeleton;GO:0001725 stress fiber", "go_biological_process": "GO:0007507 heart development;GO:0030154 cell differentiation;GO:0030036 actin cytoskeleton organization;GO:0045669 positive regulation of osteoblast differentiation;GO:0001503 ossification", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9Z1Z9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M820-1", "uniprot_id": [ { "id": "MOFA1_RAT", "url": "https://www.uniprot.org/uniprot/Q5M820", "type": "external" } ], "mass": 14222.0, "length": 125, "protein_name": "MORF4 family-associated protein 1", "gene_name": "Man2b2; Mrfap1", "organism": "Rat", "refseq_name": "MORF4 family-associated protein 1", "refseq_ac": [ { "id": "NP_001009264", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009264", "type": "external" } ], "gene_names_uniprotkb": "Man2b2; Mrfap1; Mrfap1; Pgr1", "gene_names_refseq": "Mrfap1; Pgr1; RGD1306635", "protein_names_uniprotkb": "MORF4 family-associated protein 1; T-cell activation protein-related protein", "protein_names_refseq": "MORF4 family-associated protein 1; Mof4 family associated protein 1; T-cell activation protein-related protein", "tax_id": 10116, "disease": "", "pathway": " (rno:282585)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12393805", "class_list": "", "function": "Specifically cleaves terminal alpha 1,6-linked mannose residues on Man3GlcNAc and Man2GlcNAc core oligosaccharides generated by N-glycan degradation pathways, having little activity, if any, on larger mannose oligosaccharides. Does not cleave terminal alpha 1,6-linked mannose on Man3GlcNAc2, and is also unable to hydrolyze terminal alpha 1,3-mannose linkages., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K3W6", "ec_number_list": [ { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0004559 alpha-mannosidase activity;GO:0008496 mannan endo-1,6-alpha-mannosidase activity;GO:0052767 mannosyl-oligosaccharide 1,6-alpha-mannosidase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0043202 lysosomal lumen;GO:0005576 extracellular region", "go_biological_process": "GO:0006013 mannose metabolic process;GO:0009313 oligosaccharide catabolic process;GO:0006516 glycoprotein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5M820-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62838-1", "uniprot_id": [ { "id": "MUSK_RAT", "url": "https://www.uniprot.org/uniprot/Q62838", "type": "external" } ], "mass": 96822.0, "length": 868, "protein_name": "Muscle, skeletal receptor tyrosine protein kinase", "gene_name": "Musk", "organism": "Rat", "refseq_name": "muscle, skeletal receptor tyrosine protein kinase precursor", "refseq_ac": [ { "id": "NP_112323", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112323", "type": "external" } ], "gene_names_uniprotkb": "Musk", "gene_names_refseq": "Musk; Nsk1", "protein_names_uniprotkb": "Muscle, skeletal receptor tyrosine protein kinase; 2.7.10.1; MuSK; Muscle-specific kinase receptor; Muscle-specific tyrosine protein kinase receptor", "protein_names_refseq": "muscle specific kinase (neural fold/somite kinase 1); muscle, skeletal receptor tyrosine protein kinase precursor; muscle, skeletal receptor tyrosine protein kinase; muscle, skeletal, receptor tyrosine kinase; muscle-specific kinase receptor; muscle-specific tyrosine kinase receptor MuSK; muscle-specific tyrosine protein kinase receptor", "tax_id": 10116, "disease": "congenital myasthenic syndrome 9 (Disease Ontology:DOID:0110670); fetal akinesia deformation sequence syndrome 1 (Disease Ontology:DOID:0111377); myasthenia gravis (Disease Ontology:DOID:437)", "pathway": " (rno:81725)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "12220490;15159418;16870737;17011580;18848351;19038220;19664639;20603078;23326516;29604268;7546737", "class_list": "", "function": "Low endurance exercise plus blood flow restriction improves the MuSK and hypertrophy index of both slow and fast muscles of elderly rats probably through the rise of PGC-1alpha expression, [RefSeq, PubMed]; Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle (PubMed:23326516). Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role in acetylcholinesterase (AChE) localization at the neuromuscular junctions (NMJ) via its interaction wit COLQ (PubMed:15159418). May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" } ], "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0046872 metal ion binding;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0031594 neuromuscular junction;GO:0043235 receptor complex;GO:0045202 synapse", "go_biological_process": "GO:0032224 positive regulation of synaptic transmission, cholinergic;GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering;GO:0001934 positive regulation of protein phosphorylation;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007528 neuromuscular junction development", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q62838-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.1000000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09414-1", "uniprot_id": [ { "id": "NFIA_RAT", "url": "https://www.uniprot.org/uniprot/P09414", "type": "external" } ], "mass": 55976.0, "length": 509, "protein_name": "Nuclear factor 1 A-type", "gene_name": "Nfia", "organism": "Rat", "refseq_name": "nuclear factor 1 A-type isoform 2", "refseq_ac": [ { "id": "NP_037120", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037120", "type": "external" } ], "gene_names_uniprotkb": "Nfia; Nf1l21", "gene_names_refseq": "Nfia", "protein_names_uniprotkb": "Nuclear factor 1 A-type; CCAAT-box-binding transcription factor; CTF; NF-I/A; NF1-A; NFI-A; Nuclear factor 1/A; Nuclear factor I/A; TGGCA-binding protein", "protein_names_refseq": "CCAAT-box-binding transcription factor; CTF; NF-I/A; NF1-A; NFI-A; TGGCA-binding protein; nuclear factor 1 A-type isoform 2; nuclear factor 1 A-type; nuclear factor 1/A", "tax_id": 10116, "disease": "NFIA-related disorder (Disease Ontology:DOID:0060409)", "pathway": " (rno:25492)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11835404;22673903;3053160;8832903;9089412", "class_list": "", "function": "Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q54A99;Q63782", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:1904010 response to Aroclor 1254;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0000902 cell morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P09414-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TSU1-1", "uniprot_id": [ { "id": "BIG2_RAT", "url": "https://www.uniprot.org/uniprot/Q7TSU1", "type": "external" } ], "mass": 201974.0, "length": 1791, "protein_name": "Brefeldin A-inhibited guanine nucleotide-exchange protein 2", "gene_name": "Arfgef2", "organism": "Rat", "refseq_name": "brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform 1", "refseq_ac": [ { "id": "NP_851597", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_851597", "type": "external" } ], "gene_names_uniprotkb": "Arfgef2; Arfgep2; Big2", "gene_names_refseq": "Arfgef2; Big2", "protein_names_uniprotkb": "Brefeldin A-inhibited guanine nucleotide-exchange protein 2; ADP-ribosylation factor guanine nucleotide-exchange factor 2; Brefeldin A-inhibited GEP 2", "protein_names_refseq": "ADP ribosylation factor guanine nucleotide exchange factor 2; ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited); Brefeldin A-inhibited guanine nucleotide-exchange factor 2; brefeldin A-inhibited GEP 2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform 1; brefeldin A-inhibited guanine nucleotide-exchange protein 2", "tax_id": 10116, "disease": "periventricular nodular heterotopia (Disease Ontology:DOID:0050454)", "pathway": " (rno:296380)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11809827;15198677;22673903", "class_list": "", "function": "Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017022 myosin binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0034237 protein kinase A regulatory subunit binding;GO:0050811 GABA receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005813 centrosome", "go_biological_process": "GO:0015031 protein transport;GO:0035556 intracellular signal transduction;GO:0007032 endosome organization;GO:0032760 positive regulation of tumor necrosis factor production;GO:0001881 receptor recycling", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7TSU1-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41565-1", "uniprot_id": [ { "id": "IDHG1_RAT", "url": "https://www.uniprot.org/uniprot/P41565", "type": "external" } ], "mass": 42851.0, "length": 393, "protein_name": "Isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial", "gene_name": "Idh3g", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Idh3g", "gene_names_refseq": "", "protein_names_uniprotkb": "Isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial; Isocitric dehydrogenase subunit gamma; NAD(+)-specific ICDH subunit gamma", "protein_names_refseq": "", "tax_id": 10116, "disease": "early infantile epileptic encephalopathy (Disease Ontology:DOID:0050709)", "pathway": " (rno:25179); (R-RNO-71403)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "22673903;8240232;9286695", "class_list": "", "function": "Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P70577", "ec_number_list": [], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0008047 enzyme activator activity;GO:0051287 NAD binding;GO:0004449 isocitrate dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0001917 photoreceptor inner segment;GO:0045242 isocitrate dehydrogenase complex (NAD+)", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006102 isocitrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P41565-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97570-1", "uniprot_id": [ { "id": "PLPL9_RAT", "url": "https://www.uniprot.org/uniprot/P97570", "type": "external" } ], "mass": 89556.0, "length": 807, "protein_name": "85/88 kDa calcium-independent phospholipase A2", "gene_name": "Pla2g6", "organism": "Rat", "refseq_name": "85/88 kDa calcium-independent phospholipase A2 isoform 1", "refseq_ac": [ { "id": "NP_001005560", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005560", "type": "external" } ], "gene_names_uniprotkb": "Pla2g6; Pnpla9", "gene_names_refseq": "GVI PLA2; PNPLA9; Pla2g6; caI-PLA2; iPLA2-beta; iPla2", "protein_names_uniprotkb": "85/88 kDa calcium-independent phospholipase A2; 2-lysophosphatidylcholine acylhydrolase; 3.1.1.4; 3.1.1.5; 3.1.2.2; CaI-PLA2; GVI PLA2; Group VI phospholipase A2; Intracellular membrane-associated calcium-independent phospholipase A2 beta; PNPLA9; Palmitoyl-CoA hydrolase; Patatin-like phospholipase domain-containing protein 9; iPLA2-beta", "protein_names_refseq": "2-lysophosphatidylcholine acylhydrolase; 85 kDa calcium-independent phospholipase A2; 85/88 kDa calcium-independent phospholipase A2 isoform 1; 85/88 kDa calcium-independent phospholipase A2; intracellular membrane-associated calcium-independent phospholipase A2 beta; palmitoyl-CoA hydrolase; patatin-like phospholipase domain-containing protein 9; phospholipase A2, group VI (cytosolic, calcium-independent)", "tax_id": 10116, "disease": "Parkinson's disease 14 (Disease Ontology:DOID:0060900); dystonia 12 (Disease Ontology:DOID:0090056); neurodegeneration with brain iron accumulation 2a (Disease Ontology:DOID:0110735); neurodegeneration with brain iron accumulation 2b (Disease Ontology:DOID:0110736); pleurisy (Disease Ontology:DOID:10247); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330); neuroaxonal dystrophy (Disease Ontology:DOID:2367)", "pathway": " (rno:360426); (R-RNO-1482788); (R-RNO-1482839); (R-RNO-2029485); (R-RNO-6811436)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "11118454;12089145;18937505;22673903;24648512;25979360;26206229;26632509;27973457;29637744;9111008", "class_list": "", "function": "Calcium-independent phospholipase involved in phospholipid remodeling with implications in cellular membrane homeostasis, mitochondrial integrity and signal transduction. Hydrolyzes the ester bond of the fatty acyl group attached at sn-1 or sn-2 position of phospholipids (phospholipase A1 and A2 activity respectively), producing lysophospholipids that are used in deacylation-reacylation cycles (PubMed:18937505, PubMed:9111008). Hydrolyzes both saturated and unsaturated long fatty acyl chains in various glycerophospholipid classes such as phosphatidylcholines, phosphatidylethanolamines and phosphatidates, with a preference for hydrolysis at sn-2 position. Can further hydrolyze lysophospholipids carrying saturated fatty acyl chains (lysophospholipase activity) (PubMed:18937505). Upon oxidative stress, contributes to remodeling of mitochondrial phospholipids in pancreatic beta cells, in a repair mechanism to reduce oxidized lipid content (PubMed:24648512). Preferentially hydrolyzes oxidized polyunsaturated fatty acyl chains from cardiolipins, yielding monolysocardiolipins that can be reacylated with unoxidized fatty acyls to regenerate native cardiolipin species. Hydrolyzes oxidized glycerophosphoethanolamines present in pancreatic islets, releasing oxidized polyunsaturated fatty acids such as hydroxyeicosatetraenoates (HETEs) (PubMed:24648512). Has thioesterase activity toward fatty-acyl CoA releasing CoA-SH known to facilitate fatty acid transport and beta-oxidation in mitochondria particularly in skeletal muscle (PubMed:18937505). Plays a role in regulation of membrane dynamics and homeostasis. Selectively hydrolyzes sn-2 arachidonoyl group in plasmalogen phospholipids, structural components of lipid rafts and myelin (By similarity). Regulates F-actin polymerization at the pseudopods, which is required for both speed and directionality of MCP1/CCL2-induced monocyte chemotaxis (By similarity). Targets membrane phospholipids to produce potent lipid signaling messengers. Generates lysophosphatidate (LPA, 1-acyl-glycerol-3-phosphate), which acts via G-protein receptors in various cell types. Has phospholipase A2 activity toward platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine), likely playing a role in inactivation of this potent pro-inflammatory signaling lipid (By similarity). In response to glucose, amplifies calcium influx in pancreatic beta cells to promote INS secretion (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed, UniProtKB]; Data suggest glucose-induced insulin secretion is first up-regulated (acute infection), then down-regulated (chronic infection) in beta cells infected with S. aureus; Pla2g4a is up-regulated in acute infection; Pla2g6 is up-regulated in chronic infection., [RefSeq, PubMed]; Leptin was shown to significantly inhibit the activity of iPLA2, which is considered to play crucial roles in non-apoptotic cell death, resulting in effective prevention of ischemia-induced myocyte death., [RefSeq, PubMed]; Membrane potential sensitive activity is the iPLA2gamma, [RefSeq, PubMed]; PEDF can protect against hypoxia-induced activation of the NLRP3 inflammasome by inhibiting mitochondrial fission though PEDFR/iPLA2. Publication Status: Online-Only, [RefSeq, PubMed]; The agonist-stimulated release of arachidonic acid (AA) from cellular phospholipids in many cell types (e.g. myocytes, beta-cells, and neurons) has been demonstrated to be primarily mediated by calcium-independent phospholipases A(2) (iPLA(2)s)., [RefSeq, PubMed]; The transcriptional activation of nuclear factor of activated T-cell proteins (NFATs), but not nuclear factor-kappaB, by IL-1beta stimulation was markedly attenuated by the iPLA2 inhibitor bromoenol lactone, and NFATc4 knockdown markedly attenuated the IL-1beta-induced expression of both CCL2 and CXCL10., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3V7M8;Q66HD1", "ec_number_list": [ { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.5.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.6", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.1", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "3.1.2.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.14", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.43", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.43", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "2.3.1.149", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.149", "type": "external" }, { "id": "3.4.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" } ], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0017171 serine hydrolase activity;GO:0004622 phosphatidylcholine lysophospholipase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005886 plasma membrane;GO:0031143 pseudopodium", "go_biological_process": "GO:0046338 phosphatidylethanolamine catabolic process;GO:0046473 phosphatidic acid metabolic process;GO:0034638 phosphatidylcholine catabolic process;GO:0001934 positive regulation of protein phosphorylation;GO:0006935 chemotaxis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P97570-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88954-1", "uniprot_id": [ { "id": "MPP3_RAT", "url": "https://www.uniprot.org/uniprot/O88954", "type": "external" } ], "mass": 66589.0, "length": 585, "protein_name": "MAGUK p55 subfamily member 3", "gene_name": "Mpp3", "organism": "Rat", "refseq_name": "MAGUK p55 subfamily member 3", "refseq_ac": [ { "id": "NP_446120", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446120", "type": "external" } ], "gene_names_uniprotkb": "Mpp3; Dlg3; Dusp3", "gene_names_refseq": "CSG18; Dlg3; Dusp3; Mpp3", "protein_names_uniprotkb": "MAGUK p55 subfamily member 3; Discs large homolog 3; Protein MPP3", "protein_names_refseq": "MAGUK p55 subfamily member 3; discs large homolog 3; membrane palmitoylated protein 3; membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3); protein Dlgh3; protein MPP3", "tax_id": 10116, "disease": "", "pathway": " (rno:114202)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;9753324", "class_list": "", "function": "Participates in cell spreading through the phosphoinositide-3-kinase (PI3K) pathway by connecting CADM1 to DLG1 and the regulatory subunit of phosphoinositide-3-kinase (PI3K) (By similarity). Stabilizes HTR2C at the plasma membrane and prevents its desensitization. May participates in the maintenance of adherens junctions (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6HJG0", "ec_number_list": [], "go_molecular_function": "GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005912 adherens junction;GO:0016324 apical plasma membrane;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O88954-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTY2-1", "uniprot_id": [ { "id": "REM2_RAT", "url": "https://www.uniprot.org/uniprot/Q9WTY2", "type": "external" } ], "mass": 37275.0, "length": 341, "protein_name": "GTP-binding protein REM 2", "gene_name": "Rem2", "organism": "Rat", "refseq_name": "GTP-binding protein REM 2", "refseq_ac": [ { "id": "NP_073176", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073176", "type": "external" } ], "gene_names_uniprotkb": "Rem2", "gene_names_refseq": "Rem2", "protein_names_uniprotkb": "GTP-binding protein REM 2; Rad and Gem-like GTP-binding protein 2", "protein_names_refseq": "GEM, REM, Kir family small G-protein; GTP-binding protein REM 2; GTP-binding protein REM2; RAS (RAD and GEM) like GTP binding 2; Ras-related GTP-binding protein of the Rad/Gem/Kir family, member 2; rad and Gem-like GTP-binding protein 2; rad and gem related GTP binding protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:64626)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10727423;16237180;18068949;21485012;22673903;22684057;22815963;24403140;28259675;29393594;29809135", "class_list": "", "function": "Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis., [UniProtKB, PubMed]; Our results suggest that Rem2 regulates dendritic branching and synapse development, [RefSeq, PubMed]; Rem2 has a role in neuronal plasticity hrough co-trafficking with CaMKIIa, [RefSeq, PubMed]; Rem2 is regulated at the transcriptional level by calcium influx and inhibits dendritic arborization in cultured rat cortical neurons, [RefSeq, PubMed]; Rem2 localizes to the plasma membrane via a C-terminal motif and interacts with calcium channel beta subunits in the preassembled N-type channel, thereby forming a nonconducting species., [RefSeq, PubMed]; Rem2 stabilizes intrinsic excitability and spontaneous firing in visual circuits. Publication Status: Online-Only, [RefSeq, PubMed]; Structure of the Rem2 G domain bound to GDP is reported here in a monoclinic crystal form at 2.66 A resolution, [RefSeq, PubMed]; Voltage dependant calcium channels blockade by Rem2 is likely to be controlled by both the localized concentration of membrane phosphorylated phosphatidylinositide lipids and direct 14-3-3 binding to the Rem2 C-terminus., [RefSeq, PubMed]; When rats become maternal, they increase the expression of Rem2 in the medial preoptic area which inhibits dendritic complexity and associates with an enhancement of maternal responsiveness., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5D202", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0005246 calcium channel regulator activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9WTY2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2Q1-1", "uniprot_id": [ { "id": "SC31A_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z2Q1", "type": "external" } ], "mass": 135272.0, "length": 1249, "protein_name": "Protein transport protein Sec31A", "gene_name": "Sec31a", "organism": "Rat", "refseq_name": "protein transport protein Sec31A isoform 1", "refseq_ac": [ { "id": "NP_148981", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_148981", "type": "external" } ], "gene_names_uniprotkb": "Sec31a; Sec31l1; Vap1", "gene_names_refseq": "Sec31a; Sec31l1; VAP1", "protein_names_uniprotkb": "Protein transport protein Sec31A; SEC31-like protein 1; SEC31-related protein A; Vesicle-associated protein 1", "protein_names_refseq": "SEC31 homolog A, COPII coat complex component; SEC31 homolog A, COPII coating complex component; SEC31-like 1; SEC31-like protein 1; SEC31-related protein A; protein transport protein Sec31A isoform 1; protein transport protein Sec31A; vesicle associated protein; vesicle-associated protein 1", "tax_id": 10116, "disease": "Halperin-Birk syndrome (Disease Ontology:DOID:0070539)", "pathway": " (rno:93646); (R-RNO-204005); (R-RNO-2132295); (R-RNO-983170)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "10574704;10788476;16396499;18683930;22673903;28627649;29393594;29716612;34502162", "class_list": "", "function": "Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The present study provided evidence that VAP-1 expression is upregulated by hypoxia during acute hemorrhagic shock, and that inhibition of VAP-1 may be beneficial in the setting of hemorrhagic shock., [RefSeq, PubMed]; VAP-1 is expressed in the vasculature within induced focal experimental autoimmune encephalomyelitis during the acute phase of inflammation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5RKK4", "ec_number_list": [], "go_molecular_function": "GO:0048306 calcium-dependent protein binding;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0090110 COPII-coated vesicle cargo loading;GO:0015031 protein transport;GO:0051592 response to calcium ion;GO:0007029 endoplasmic reticulum organization;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9Z2Q1-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KLG9-1", "uniprot_id": [ { "id": "ZFN2B_RAT", "url": "https://www.uniprot.org/uniprot/Q4KLG9", "type": "external" } ], "mass": 27925.0, "length": 257, "protein_name": "AN1-type zinc finger protein 2B", "gene_name": "Zfand2b", "organism": "Rat", "refseq_name": "AN1-type zinc finger protein 2B", "refseq_ac": [ { "id": "NP_001020916", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020916", "type": "external" } ], "gene_names_uniprotkb": "Zfand2b", "gene_names_refseq": "RGD1306260; Zfand2b", "protein_names_uniprotkb": "AN1-type zinc finger protein 2B; AIRAP-like protein; Arsenite-inducible RNA-associated protein-like protein", "protein_names_refseq": "AIRAP-like protein; AN1-type zinc finger protein 2B; arsenite-inducible RNA-associated protein-like protein; zinc finger, AN1 type domain 2B", "tax_id": 10116, "disease": "", "pathway": " (rno:363253)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Plays a role in protein homeostasis by regulating both the translocation and the ubiquitin-mediated proteasomal degradation of nascent proteins at the endoplasmic reticulum. It is involved in the regulation of signal-mediated translocation of proteins into the endoplasmic reticulum. It also plays a role in the ubiquitin-mediated proteasomal degradation of proteins for which signal-mediated translocation to the endoplasmic reticulum has failed. May therefore function in the endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0036435 K48-linked polyubiquitin modification-dependent protein binding;GO:0008270 zinc ion binding;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0000502 proteasome complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045047 protein targeting to ER;GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation;GO:0043567 regulation of insulin-like growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4KLG9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M7V8-1", "uniprot_id": [ { "id": "TR150_RAT", "url": "https://www.uniprot.org/uniprot/Q5M7V8", "type": "external" } ], "mass": 108252.0, "length": 951, "protein_name": "Thyroid hormone receptor-associated protein 3", "gene_name": "Thrap3", "organism": "Rat", "refseq_name": "thyroid hormone receptor-associated protein 3", "refseq_ac": [ { "id": "NP_001009693", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009693", "type": "external" } ], "gene_names_uniprotkb": "Thrap3; Trap150", "gene_names_refseq": "Thrap3", "protein_names_uniprotkb": "Thyroid hormone receptor-associated protein 3; Thyroid hormone receptor-associated protein complex 150 kDa component; Trap150", "protein_names_refseq": "thyroid hormone receptor-associated protein 3; thyroid hormone receptor-associated protein complex 150 kDa component; trap150", "tax_id": 10116, "disease": "", "pathway": " (rno:313591)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16641100;22673903", "class_list": "", "function": "Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 33, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003713 transcription coactivator activity;GO:0005524 ATP binding;GO:0051219 phosphoprotein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0016592 mediator complex;GO:0035145 exon-exon junction complex", "go_biological_process": "GO:0048026 positive regulation of mRNA splicing, via spliceosome;GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0048255 mRNA stabilization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5M7V8-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ESQ5-1", "uniprot_id": [ { "id": "TRPM4_RAT", "url": "https://www.uniprot.org/uniprot/Q9ESQ5", "type": "external" } ], "mass": 135341.0, "length": 1208, "protein_name": "Transient receptor potential cation channel subfamily M member 4", "gene_name": "Trpm4", "organism": "Rat", "refseq_name": "transient receptor potential cation channel subfamily M member 4", "refseq_ac": [ { "id": "NP_001129701", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129701", "type": "external" } ], "gene_names_uniprotkb": "Trpm4; Ltrpc4", "gene_names_refseq": "LTrpC-4; Mls2s; Trpm4", "protein_names_uniprotkb": "Transient receptor potential cation channel subfamily M member 4; Calcium-activated non-selective cation channel 1; LTrpC-4; LTrpC4; Long transient receptor potential channel 4; MLS2s; Melastatin-like 2", "protein_names_refseq": "LTrpC4; calcium-activated non-selective cation channel 1; long transient receptor potential channel 4; melastatin like 2 protein; melastatin-like 2; transient receptor potential cation channel subfamily M member 4", "tax_id": 10116, "disease": "cardiac arrest (Disease Ontology:DOID:0060319); erythrokeratodermia variabilis et progressiva 6 (Disease Ontology:DOID:0080766); progressive familial heart block type IB (Disease Ontology:DOID:0111076)", "pathway": " (rno:171143); (R-RNO-3295583)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "15030426;15472118;16806463;16966582;19945433;22673903;32619565;34144257;35099165;35163382;37404129", "class_list": "", "function": "A Central Role for TRPM4 in Ca(2+)-Signal Amplification and Vasoconstriction. Publication Status: Online-Only, [RefSeq, PubMed]; Activation of TRPM4-dependent currents contributed to myogenic vasoconstriction of cerebral arteries., [RefSeq, PubMed]; Calcium-activated selective cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane (PubMed:16966582, PubMed:19945433). It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway. Plays a role in keratinocyte differentiation (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; Cholinergic modulation shifts the response of CA1 pyramidal cells to depolarizing ramps via TRPM4 channels with potential implications for place field firing. Publication Status: Online-Only, [RefSeq, PubMed]; Insulin-secreting cells of the pancreatic beta-cell line INS-1 natively express TRPM4 proteins and generate large depolarizing membrane currents in response to increased intracellular calcium, [RefSeq, PubMed]; Lacks channel activity., [UniProtKB, PubMed]; May contribute to the transient inward current implicated in delayed-after-depolarizations observed during [Ca(2+)] overload of cardiomyocytes., [RefSeq, PubMed]; Role of the TRPM4 channel in mitochondrial function, calcium release, and ROS generation in oxidative stress. Erratum:[Biochem Biophys Res Commun. 2021 Oct 20;575:96-98. doi: 10.1016/j.bbrc.2021.08.041. PMID: 34452699], [RefSeq, PubMed]; TRPM4 inhibition improves spatial memory impairment and hippocampal long-term potentiation deficit in chronic cerebral hypoperfused rats., [RefSeq, PubMed]; Unraveling the Cardiac Effects Induced by Carvacrol in Spontaneously Hypertensive Rats: Involvement of Transient Receptor Potential Melastatin Subfamily 4 and 7 Channels. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043025 neuronal cell body", "go_biological_process": "GO:0086048 membrane depolarization during bundle of His cell action potential;GO:1904179 positive regulation of adipose tissue development;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0008284 positive regulation of cell population proliferation;GO:0016925 protein sumoylation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9ESQ5-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0R8U1-1", "uniprot_id": [ { "id": "DYH5_RAT", "url": "https://www.uniprot.org/uniprot/M0R8U1", "type": "external" } ], "mass": 395933.0, "length": 3470, "protein_name": "Dynein axonemal heavy chain 5", "gene_name": "Dnah5", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Dnah5", "gene_names_refseq": "", "protein_names_uniprotkb": "Dynein axonemal heavy chain 5; Axonemal beta dynein heavy chain 5; Ciliary dynein heavy chain 5", "protein_names_refseq": "", "tax_id": 10116, "disease": "Kartagener syndrome (Disease Ontology:DOID:0050144); visceral heterotaxy (Disease Ontology:DOID:0050545); primary ciliary dyskinesia 3 (Disease Ontology:DOID:0110599); otitis media (Disease Ontology:DOID:10754); tetralogy of Fallot (Disease Ontology:DOID:6419); primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": " (rno:294854)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21496787", "class_list": "", "function": "Force generating protein of respiratory cilia (By similarity). Produces force towards the minus ends of microtubules (By similarity). Key component of dynein, a family of motor proteins essential for movement along microtubules (By similarity). Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity). Required for structural and functional integrity of the cilia of ependymal cells lining the brain ventricles., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0003777 microtubule motor activity;GO:0008569 minus-end-directed microtubule motor activity;GO:0051959 dynein light intermediate chain binding;GO:0045505 dynein intermediate chain binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0031514 motile cilium;GO:0005930 axoneme", "go_biological_process": "GO:0060294 cilium movement involved in cell motility;GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0007507 heart development;GO:0030317 flagellated sperm motility;GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "M0R8U1-1", "record_type": "protein", "filter_code": "0000000.0000111.001000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62950-1", "uniprot_id": [ { "id": "DPYL1_RAT", "url": "https://www.uniprot.org/uniprot/Q62950", "type": "external" } ], "mass": 62196.0, "length": 572, "protein_name": "Dihydropyrimidinase-related protein 1", "gene_name": "Crmp1", "organism": "Rat", "refseq_name": "dihydropyrimidinase-related protein 1 isoform 2", "refseq_ac": [ { "id": "NP_037064", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037064", "type": "external" } ], "gene_names_uniprotkb": "Crmp1; Dpysl1", "gene_names_refseq": "Crmp1", "protein_names_uniprotkb": "Dihydropyrimidinase-related protein 1; CRMP-1; Collapsin response mediator protein 1; DRP-1; Inactive dihydropyrimidinase", "protein_names_refseq": "CRMP-1; DRP-1; dihydropyrimidinase-related protein 1 isoform 2; dihydropyrimidinase-related protein 1; inactive dihydropyrimidinase", "tax_id": 10116, "disease": "", "pathway": " (rno:25415); (R-RNO-399956)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "18683930;22673903;25358863;32880477;33771901;38105470;38142589;38843836;8815901;9375656", "class_list": "", "function": "FEZ1 Forms Complexes with CRMP1 and DCC to Regulate Axon and Dendrite Development. Publication Status: Online-Only, [RefSeq, PubMed]; High sugar but not high fat diet consumption induces hepatic metabolic disruption and up-regulation of mitochondrial fission-associated protein Drp1 in a model of moderate obesity., [RefSeq, PubMed]; LKB1 and CRMP1 cooperatively promote the repair of the sciatic nerve injury., [RefSeq, PubMed]; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (By similarity). Plays a role in axon guidance (By similarity). During the axon guidance process, acts downstream of SEMA3A to promote FLNA dissociation from F-actin which results in the rearrangement of the actin cytoskeleton and the collapse of the growth cone (By similarity). Involved in invasive growth and cell migration. May participate in cytokinesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance. During the axon guidance process, acts downstream of SEMA3A to promote FLNA dissociation from F-actin which results in the rearrangement of the actin cytoskeleton and the collapse of the growth cone. Involved in invasive growth and cell migration. May participate in cytokinesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Role of the RIP3-PGAM5-Drp1 pathway in aluminum-induced PC12 cells necroptosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P70546", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0051219 phosphoprotein binding;GO:0031005 filamin binding;GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides;GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds", "go_cellular_component": "GO:0005813 centrosome;GO:0005819 spindle;GO:0005829 cytosol;GO:0015629 actin cytoskeleton;GO:0030425 dendrite", "go_biological_process": "GO:0071526 semaphorin-plexin signaling pathway;GO:0010977 negative regulation of neuron projection development;GO:0048666 neuron development;GO:0150052 regulation of postsynapse assembly", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q62950-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q761X5-1", "uniprot_id": [ { "id": "UNC5C_RAT", "url": "https://www.uniprot.org/uniprot/Q761X5", "type": "external" } ], "mass": 103135.0, "length": 931, "protein_name": "Netrin receptor UNC5C", "gene_name": "Unc5c", "organism": "Rat", "refseq_name": "netrin receptor UNC5C isoform 2 precursor", "refseq_ac": [ { "id": "NP_955439", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955439", "type": "external" } ], "gene_names_uniprotkb": "Unc5c; Unc5h3", "gene_names_refseq": "Unc5c", "protein_names_uniprotkb": "Netrin receptor UNC5C; Protein unc-5 homolog 3; Protein unc-5 homolog C", "protein_names_refseq": "netrin receptor UNC5C isoform 2 precursor; netrin receptor UNC5C; protein unc-5 homolog 3; protein unc-5 homolog C; unc-5 homolog 3", "tax_id": 10116, "disease": "", "pathway": " (rno:362049)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11387206;15010202;22405201;22673903;25419706", "class_list": "", "function": "Receptor for netrin required for axon guidance (By similarity). Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity). NTN1/Netrin-1 binding might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (By similarity). Might also collaborate with DSCAM in NTN1-mediated axon repulsion independently of DCC (By similarity). Also involved in corticospinal tract axon guidance independently of DCC (By similarity). Involved in dorsal root ganglion axon projection towards the spinal cord (By similarity). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:11387206)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; T835M (rs137875858) in UNC5C increased hippocampal neuronal cell death and susceptibility to neurotoxic stimuli., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0015631 tubulin binding;GO:0005042 netrin receptor activity;GO:0005043 netrin receptor activity involved in chemorepulsion", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030027 lamellipodium;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0007420 brain development;GO:0030334 regulation of cell migration;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q761X5-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2RUW1-1", "uniprot_id": [ { "id": "TOLIP_RAT", "url": "https://www.uniprot.org/uniprot/A2RUW1", "type": "external" } ], "mass": 30315.0, "length": 274, "protein_name": "Toll-interacting protein", "gene_name": "Tollip", "organism": "Rat", "refseq_name": "toll-interacting protein", "refseq_ac": [ { "id": "NP_001103138", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103138", "type": "external" } ], "gene_names_uniprotkb": "Tollip", "gene_names_refseq": "Tollip", "protein_names_uniprotkb": "Toll-interacting protein", "protein_names_refseq": "toll-interacting protein", "tax_id": 10116, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (rno:361677); (R-RNO-6798695); (R-RNO-9020702)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "22673903;23656243;25269519;26011492;28056921;29142263", "class_list": "", "function": "Component of the signaling pathway of IL-1 and Toll-like receptors (By similarity). Inhibits cell activation by microbial products (By similarity). Recruits IRAK1 to the IL-1 receptor complex (By similarity). Inhibits IRAK1 phosphorylation and kinase activity. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates (By similarity). The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity). In a complex with TOM1, recruits ubiquitin-conjugated proteins onto early endosomes (By similarity). Binds to phosphatidylinositol 3-phosphate (PtdIns(3)P) (By similarity)., [UniProtKB, UniProtKB]; Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates. In a complex with TOM1, recruits ubiquitin-conjugated proteins onto early endosomes. Binds to phosphatidylinositol 3-phosphate (PtdIns(3)P)., [UniProtKB, UniProtKB]; Daata indicate that Xuebijing (XBJ) significantly reduced ligation and puncture (CLP)-induced lung permeability by upregulating Toll-interacting protein (Tollip) expression., [RefSeq, PubMed]; The disbalance between TLRs and their negative regulating factors PPAR-gamma and Tollip was closely associated with the course of colitis., [RefSeq, PubMed]; This study demonstrated B. adolescentis prevents NEC in preterm neonatal rats and that the mechanism for this action might be associated with the alteration of TLR4, TOLLIP, and SIGIRR expression. Publication Status: Online-Only, [RefSeq, PubMed]; Tollip acts as a novel modulator of I/R injury by promoting neuronal apoptosis and ischaemic inflammation, which are largely mediated by suppression of Akt signalling., [RefSeq, PubMed]; We have identified miR291b as a critical miRNA up-regulated by ethanol. Normalization of the miR291b --> Tollip pathway by HA35 ameliorated ethanol-induced sensitization of TLR4 signaling in macrophages/monocytes, suggesting that HA35 may be a novel therapeutic agent in the treatment of Alcoholic liver disease. Erratum:[Sci Rep. 2025 Mar 21;15(1):9766. doi: 10.1038/s41598-025-94493-1. PMID: 40118974] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005150 interleukin-1, type I receptor binding;GO:0031625 ubiquitin protein ligase binding;GO:0019900 kinase binding;GO:0031624 ubiquitin conjugating enzyme binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0070498 interleukin-1-mediated signaling pathway;GO:0006954 inflammatory response;GO:0007165 signal transduction;GO:0030855 epithelial cell differentiation;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A2RUW1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70645-1", "uniprot_id": [ { "id": "BLMH_RAT", "url": "https://www.uniprot.org/uniprot/P70645", "type": "external" } ], "mass": 52323.0, "length": 454, "protein_name": "Bleomycin hydrolase", "gene_name": "Blmh", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Blmh", "gene_names_refseq": "", "protein_names_uniprotkb": "Bleomycin hydrolase; 3.4.22.40; BH; BLM hydrolase; BMH", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-983168)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "8889821;8907172", "class_list": "", "function": "The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity (By similarity). Binds single-stranded DNA with higher affinity than double-stranded DNA. May play an important role in the metabolism of antibiotics., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-", "type": "external" }, { "id": "3.4.11.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.14", "type": "external" }, { "id": "3.4.22.40", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.40", "type": "external" }, { "id": "3.4.11.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.3", "type": "external" }, { "id": "3.4.14.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.10", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0004177 aminopeptidase activity;GO:0008233 peptidase activity;GO:0004197 cysteine-type endopeptidase activity;GO:0008234 cysteine-type peptidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0009636 response to toxic substance;GO:0009410 response to xenobiotic stimulus;GO:0043418 homocysteine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P70645-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55266-1", "uniprot_id": [ { "id": "DSRAD_RAT", "url": "https://www.uniprot.org/uniprot/P55266", "type": "external" } ], "mass": 129911.0, "length": 1175, "protein_name": "Double-stranded RNA-specific adenosine deaminase", "gene_name": "Adar", "organism": "Rat", "refseq_name": "double-stranded RNA-specific adenosine deaminase", "refseq_ac": [ { "id": "NP_112268", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112268", "type": "external" } ], "gene_names_uniprotkb": "Adar; Dsrad", "gene_names_refseq": "Adar", "protein_names_uniprotkb": "Double-stranded RNA-specific adenosine deaminase; 3.5.4.37; DRADA", "protein_names_refseq": "DRADA; double-stranded RNA-specific adenosine deaminase", "tax_id": 10116, "disease": "Aicardi-Goutieres syndrome (Disease Ontology:DOID:0050629); dyschromatosis symmetrica hereditaria (Disease Ontology:DOID:0060257); stomach cancer (Disease Ontology:DOID:10534); Human papillomavirus infectious disease (Disease Ontology:DOID:11166); cervical squamous cell carcinoma (Disease Ontology:DOID:3744); liver cirrhosis (Disease Ontology:DOID:5082)", "pathway": " (rno:81635); (R-RNO-75102); (R-RNO-77042); (R-RNO-9833482)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "22673903;7862132", "class_list": "", "function": "Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alters their functional activities. Exhibits low-level editing at the GRIA2 Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Does not affect polyomavirus replication but provides protection against virus-induced cytopathic effects. Essential for embryonic development and cell survival and plays a critical role in the maintenance of hematopoietic stem cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.4.37", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.37", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0008251 tRNA-specific adenosine deaminase activity;GO:0046872 metal ion binding;GO:0003725 double-stranded RNA binding;GO:0003726 double-stranded RNA adenosine deaminase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0070922 RISC complex assembly;GO:0001701 in utero embryonic development;GO:0006351 DNA-templated transcription;GO:0006396 RNA processing;GO:0006397 mRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P55266-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63520-1", "uniprot_id": [ { "id": "SYCP3_RAT", "url": "https://www.uniprot.org/uniprot/Q63520", "type": "external" } ], "mass": 29733.0, "length": 257, "protein_name": "Synaptonemal complex protein 3", "gene_name": "Sycp3", "organism": "Rat", "refseq_name": "synaptonemal complex protein 3", "refseq_ac": [ { "id": "NP_037173", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037173", "type": "external" } ], "gene_names_uniprotkb": "Sycp3; Scp3", "gene_names_refseq": "RNASCP3; Sycp3", "protein_names_uniprotkb": "Synaptonemal complex protein 3; SCP-3", "protein_names_refseq": "SCP-3; synaptonemal complex protein 3", "tax_id": 10116, "disease": "spermatogenic failure 4 (Disease Ontology:DOID:0070176); azoospermia (Disease Ontology:DOID:14227)", "pathway": " (rno:25561)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10652260;18391527;22673903;8289794;9679134;9933407", "class_list": "", "function": "Component of the synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase (PubMed:8289794, PubMed:9933407). Required for centromere pairing during meiosis in male germ cells. Required for normal meiosis during spermatogenesis and male fertility. Plays a lesser role in female fertility. Required for efficient phosphorylation of HORMAD1 and HORMAD2., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0000775 chromosome, centromeric region;GO:0000793 condensed chromosome;GO:0001673 male germ cell nucleus", "go_biological_process": "GO:0016321 female meiosis chromosome segregation;GO:0007066 female meiosis sister chromatid cohesion;GO:0000278 mitotic cell cycle;GO:0007283 spermatogenesis;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q63520-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63185-1", "uniprot_id": [ { "id": "E2AK1_RAT", "url": "https://www.uniprot.org/uniprot/Q63185", "type": "external" } ], "mass": 69586.0, "length": 620, "protein_name": "Eukaryotic translation initiation factor 2-alpha kinase 1", "gene_name": "Eif2ak1", "organism": "Rat", "refseq_name": "eukaryotic translation initiation factor 2-alpha kinase 1", "refseq_ac": [ { "id": "NP_037355", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037355", "type": "external" } ], "gene_names_uniprotkb": "Eif2ak1; Hri", "gene_names_refseq": "Eif2ak1; Hri", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 2-alpha kinase 1; 2.7.11.1; HCR; Heme-controlled repressor; Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase; Heme-regulated inhibitor; Hemin-sensitive initiation factor 2-alpha kinase", "protein_names_refseq": "HCR; eukaryotic translation initiation factor 2-alpha kinase 1; heme-controlled repressor; heme-regulated eukaryotic initiation factor eIF-2-alpha kinase; heme-regulated inhibitor; hemin-sensitive initiation factor 2-alpha kinase; hemin-sensitive initiation factor 2a kinase", "tax_id": 10116, "disease": "", "pathway": " (rno:27137); (R-RNO-9840373)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "20071449;22673903;29393594;32132707;7908290", "class_list": "", "function": "Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions. Key activator of the integrated stress response (ISR) required for adaptation to various stress, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock. EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming. Acts as a key sensor of heme-deficiency: in normal conditions, binds hemin via a cysteine thiolate and histidine nitrogenous coordination, leading to inhibit the protein kinase activity. This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell: heme depletion relieves inhibition and stimulates kinase activity, activating the ISR. Thanks to this unique heme-sensing capacity, plays a crucial role to shut off protein synthesis during acute heme-deficient conditions. In red blood cells (RBCs), controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties. It thereby plays an essential protective role for RBC survival in anemias of iron deficiency. Iron deficiency also triggers activation by full-length DELE1. Also activates the ISR in response to mitochondrial dysfunction: HRI/EIF2AK1 protein kinase activity is activated upon binding to the processed form of DELE1 (S-DELE1), thereby promoting the ATF4-mediated reprogramming (By similarity). Also acts as an activator of mitophagy in response to mitochondrial damage: catalyzes phosphorylation of eIF-2-alpha (EIF2S1) following activation by S-DELE1, thereby promoting mitochondrial localization of EIF2S1, triggering PRKN-independent mitophagy (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q642C7", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity;GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0020037 heme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0070585 protein localization to mitochondrion;GO:1901526 positive regulation of mitophagy;GO:0006417 regulation of translation;GO:0008285 negative regulation of cell population proliferation;GO:0006909 phagocytosis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q63185-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KLI2-1", "uniprot_id": [ { "id": "TM10A_RAT", "url": "https://www.uniprot.org/uniprot/Q4KLI2", "type": "external" } ], "mass": 38424.0, "length": 335, "protein_name": "tRNA methyltransferase 10 homolog A", "gene_name": "Trmt10a", "organism": "Rat", "refseq_name": "tRNA methyltransferase 10 homolog A", "refseq_ac": [ { "id": "NP_001037697", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001037697", "type": "external" } ], "gene_names_uniprotkb": "Trmt10a; Rg9mtd2", "gene_names_refseq": "Rg9mtd2; Trmt10a", "protein_names_uniprotkb": "tRNA methyltransferase 10 homolog A; 2.1.1.221; RNA (guanine-9-)-methyltransferase domain-containing protein 2; tRNA (guanine(9)-N(1))-methyltransferase TRMT10A", "protein_names_refseq": "RNA (guanine-9-) methyltransferase domain containing 2; RNA (guanine-9-)-methyltransferase domain-containing protein 2; tRNA (guanine(9)-N(1))-methyltransferase TRMT10A; tRNA methyltransferase 10 homolog A", "tax_id": 10116, "disease": "glucose metabolism disease (Disease Ontology:DOID:4194)", "pathway": " (rno:295496)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;24204302", "class_list": "", "function": "S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs. Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.221", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.221", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.218", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.218", "type": "external" } ], "go_molecular_function": "GO:0000049 tRNA binding;GO:0052905 tRNA (guanosine(9)-N1)-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol", "go_biological_process": "GO:0030488 tRNA methylation;GO:0010960 magnesium ion homeostasis;GO:0002939 tRNA N1-guanine methylation;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4KLI2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A702-1", "uniprot_id": [ { "id": "SYNP2_RAT", "url": "https://www.uniprot.org/uniprot/D4A702", "type": "external" } ], "mass": 136025.0, "length": 1262, "protein_name": "Synaptopodin-2", "gene_name": "Synpo2", "organism": "Rat", "refseq_name": "synaptopodin-2", "refseq_ac": [ { "id": "NP_001178892", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178892", "type": "external" } ], "gene_names_uniprotkb": "Synpo2", "gene_names_refseq": "RGD1564779; Synpo2", "protein_names_uniprotkb": "Synaptopodin-2; Myopodin", "protein_names_refseq": "myopodin; synaptopodin-2", "tax_id": 10116, "disease": "", "pathway": " (rno:499702)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11673475;22673903;23434281;34502162", "class_list": "", "function": "Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks. At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines (By similarity). Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (PubMed:23434281). Involved in regulation of cell migration. May be a tumor suppressor (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 26, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051371 muscle alpha-actinin binding;GO:0003779 actin binding;GO:0030674 protein-macromolecule adaptor activity;GO:0051393 alpha-actinin binding;GO:0071889 14-3-3 protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005925 focal adhesion;GO:0015629 actin cytoskeleton;GO:0001725 stress fiber;GO:0030018 Z disc", "go_biological_process": "GO:0032233 positive regulation of actin filament bundle assembly;GO:0061684 chaperone-mediated autophagy;GO:0000045 autophagosome assembly;GO:0030335 positive regulation of cell migration;GO:2000298 regulation of Rho-dependent protein serine/threonine kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "D4A702-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2EJA0-1", "uniprot_id": [ { "id": "YAP1_RAT", "url": "https://www.uniprot.org/uniprot/Q2EJA0", "type": "external" } ], "mass": 50501.0, "length": 469, "protein_name": "Transcriptional coactivator YAP1", "gene_name": "Yap1", "organism": "Rat", "refseq_name": "transcriptional coactivator YAP1 isoform 2", "refseq_ac": [ { "id": "NP_001381258", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001381258", "type": "external" } ], "gene_names_uniprotkb": "Yap1; Yap65; Yap", "gene_names_refseq": "YAP65; Yap1; Yap", "protein_names_uniprotkb": "Transcriptional coactivator YAP1; Protein yorkie homolog; Yes-associated protein 1; Yes-associated protein YAP65 homolog", "protein_names_refseq": "65 kDa Yes-associated protein; protein yorkie homolog; transcriptional coactivator YAP1 isoform 2; transcriptional coactivator YAP1; yes-associated protein 1; yes-associated protein YAP65 homolog; yorkie homolog", "tax_id": 10116, "disease": "cone dystrophy (Disease Ontology:DOID:0050795); uveal coloboma-cleft lip and palate-intellectual disability (Disease Ontology:DOID:0111249); intestinal cancer (Disease Ontology:DOID:10155); heart disease (Disease Ontology:DOID:114); coloboma (Disease Ontology:DOID:12270); neurodegenerative disease (Disease Ontology:DOID:1289); cancer (Disease Ontology:DOID:162); ovarian cancer (Disease Ontology:DOID:2394); carcinoma (Disease Ontology:DOID:305); nephrolithiasis (Disease Ontology:DOID:585); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (R-RNO-1251985); (R-RNO-2028269); (R-RNO-2032785); (R-RNO-8939236); (R-RNO-8951671); (R-RNO-9860927)", "pathway_count": 6, "publication_count": 12, "publication_id_list": "16461361;16641100;22673903;24147051;27369082;30511395;32693242;38136638;38184457;38494855;38610069;39027975", "class_list": "", "function": "Attenuates p73-mediated cell death signaling in transcriptional repression-induced atypical death (TRIAD) of neurons., [UniProtKB, PubMed]; GPX4-mediated bone ferroptosis under mechanical stress decreased bone formation via the YAP-TEAD signalling pathway., [RefSeq, PubMed]; Non-canonical IKB kinases regulate YAP/TAZ and pathological vascular remodeling behaviors in pulmonary artery smooth muscle cells., [RefSeq, PubMed]; Role of YAP in Odontoblast Damage Repair in a Dentin Hypersensitivity Model., [RefSeq, PubMed]; Transcriptional regulator with dual roles as a coactivator and corepressor. Critical downstream regulatory target in the Hippo signaling pathway, crucial for organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:16461361). The Hippo signaling pathway core involves a kinase cascade featuring STK3/MST2 and STK4/MST1, along with its regulatory partner SAV1, which phosphorylates and activates LATS1/2 in complex with their regulatory protein, MOB1. This activation leads to the phosphorylation and inactivation of the YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 prevents its nuclear translocation, thereby regulating the expression of its target genes. The transcriptional regulation of gene expression requires TEAD transcription factors and modulates cell growth, anchorage-independent growth, and induction of epithelial-mesenchymal transition (EMT). Plays a key role in tissue tension and 3D tissue shape by regulating the cortical actomyosin network, acting via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization. It also suppresses ciliogenesis by acting as a transcriptional corepressor of TEAD4 target genes AURKA and PLK1 (By similarity). In conjunction with WWTR1, regulates TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). Synergizes with WBP2 to enhance PGR activity (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Understanding the Role of Yes-Associated Protein (YAP) Signaling in the Transformation of Lens Epithelial Cells (EMT) and Fibrosis. Publication Status: Online-Only, [RefSeq, PubMed]; Upregulation of Angiomotin-Like 2 Ameliorates Experimental Pulmonary Arterial Hypertension by Inactivating YAP1 Signaling. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 24, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 11, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3LRU4;Q3LRU5;Q3LRU6", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0003714 transcription corepressor activity;GO:0070064 proline-rich region binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:1902018 negative regulation of cilium assembly;GO:0061026 cardiac muscle tissue regeneration;GO:0072307 regulation of metanephric nephron tubule epithelial cell differentiation;GO:1902459 positive regulation of stem cell population maintenance;GO:1904036 negative regulation of epithelial cell apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q2EJA0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QX75-1", "uniprot_id": [ { "id": "TRDN_RAT", "url": "https://www.uniprot.org/uniprot/Q9QX75", "type": "external" } ], "mass": 77200.0, "length": 687, "protein_name": "Triadin", "gene_name": "Trdn", "organism": "Rat", "refseq_name": "triadin", "refseq_ac": [ { "id": "NP_067698", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067698", "type": "external" } ], "gene_names_uniprotkb": "Trdn", "gene_names_refseq": "Trdn", "protein_names_uniprotkb": "Triadin", "protein_names_refseq": "triadin 1; triadin 32 kDa (TRISK 32); triadin 49 kDa (TRISK 49); triadin 95; triadin", "tax_id": 10116, "disease": "catecholaminergic polymorphic ventricular tachycardia (Disease Ontology:DOID:0060674); catecholaminergic polymorphic ventricular tachycardia 5 (Disease Ontology:DOID:0060679); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (rno:59299); (R-RNO-2672351); (R-RNO-5578775)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10713145;12955494;15927957;21811790;22673903;37589058", "class_list": "", "function": "Acute aerobic exercise regulation of myocardial calcium homeostasis involves CASQ1, CASQ2, and TRDN., [RefSeq, PubMed]; Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact. Required for normal skeletal muscle strength. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Findings show that Trisk 32 not only co-localizes with, but directly contributes to, the regulation of Ca(2+) release via IP(3) receptors, [RefSeq, PubMed]; The expression of Trdn was studied during muscle development in a novel three-dimensional muscle-neuronal coculture system., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 1, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "E9PTN7;Q5DVI6;Q5DVI7;Q9JKZ5;Q9JKZ6;Q9QX76", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0030674 protein-macromolecule adaptor activity;GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0042383 sarcolemma;GO:0014701 junctional sarcoplasmic reticulum membrane;GO:0016529 sarcoplasmic reticulum;GO:0034704 calcium channel complex", "go_biological_process": "GO:1904010 response to Aroclor 1254;GO:0051280 negative regulation of release of sequestered calcium ion into cytosol;GO:0090158 endoplasmic reticulum membrane organization;GO:0006874 intracellular calcium ion homeostasis;GO:0060047 heart contraction", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9QX75-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKY3-1", "uniprot_id": [ { "id": "ZBT18_RAT", "url": "https://www.uniprot.org/uniprot/Q9JKY3", "type": "external" } ], "mass": 58310.0, "length": 522, "protein_name": "Zinc finger and BTB domain-containing protein 18", "gene_name": "Zbtb18", "organism": "Rat", "refseq_name": "zinc finger and BTB domain-containing protein 18 isoform 1", "refseq_ac": [ { "id": "NP_073169", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073169", "type": "external" } ], "gene_names_uniprotkb": "Zbtb18; Rp58; Zfp238; Znf238", "gene_names_refseq": "Rp58; Zbtb18; Zfp238; Znf238", "protein_names_uniprotkb": "Zinc finger and BTB domain-containing protein 18; 58 kDa repressor protein; Transcriptional repressor RP58; Zinc finger protein 238; rRP58", "protein_names_refseq": "58 kDa repressor protein; rRP58; transcriptional repressor RP58; zinc finger and BTB domain-containing protein 18 isoform 1; zinc finger and BTB domain-containing protein 18; zinc finger protein 238", "tax_id": 10116, "disease": "autosomal dominant intellectual developmental disorder (Disease Ontology:DOID:0060307); autosomal dominant intellectual developmental disorder 22 (Disease Ontology:DOID:0070052)", "pathway": " (rno:64619)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12040400;22673903;37183291", "class_list": "", "function": "RP58 knockdown contributes to hypoxia-ischemia-induced pineal dysfunction and circadian rhythm disruption in neonatal rats., [RefSeq, PubMed]; Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. May also play a role in the organization of chromosomes in the nucleus (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0000792 heterochromatin", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9JKY3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z220-1", "uniprot_id": [ { "id": "TSG10_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z220", "type": "external" } ], "mass": 83012.0, "length": 712, "protein_name": "Testis-specific gene 10 protein", "gene_name": "Tsga10", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Tsga10", "gene_names_refseq": "", "protein_names_uniprotkb": "Testis-specific gene 10 protein; Cp431", "protein_names_refseq": "", "tax_id": 10116, "disease": "spermatogenic failure 26 (Disease Ontology:DOID:0111924)", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "14585816;16643851;22673903", "class_list": "", "function": "Plays a role in spermatogenesis (By similarity). When overexpressed, prevents nuclear localization of HIF1A (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031514 motile cilium;GO:0043005 neuron projection;GO:0005814 centriole;GO:0035686 sperm fibrous sheath", "go_biological_process": "GO:0030031 cell projection assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9Z220-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99MA2-1", "uniprot_id": [ { "id": "XPP2_RAT", "url": "https://www.uniprot.org/uniprot/Q99MA2", "type": "external" } ], "mass": 76080.0, "length": 674, "protein_name": "Xaa-Pro aminopeptidase 2", "gene_name": "Xpnpep2", "organism": "Rat", "refseq_name": "xaa-Pro aminopeptidase 2 precursor", "refseq_ac": [ { "id": "NP_476496", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476496", "type": "external" } ], "gene_names_uniprotkb": "Xpnpep2", "gene_names_refseq": "Xpnpep2; mAPP", "protein_names_uniprotkb": "Xaa-Pro aminopeptidase 2; 3.4.11.9; Membrane-bound APP; Membrane-bound aminopeptidase P; X-prolyl aminopeptidase 2; mAPP", "protein_names_refseq": "X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound; membrane-bound APP; membrane-bound aminopeptidase P; xaa-Pro aminopeptidase 2 precursor; xaa-Pro aminopeptidase 2-like; xaa-Pro aminopeptidase 2", "tax_id": 10116, "disease": "acquired angioedema (Disease Ontology:DOID:0080941)", "pathway": " (rno:117522); (R-RNO-163125)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "12941294;17515839;25568306;7669781", "class_list": "", "function": "Membrane-bound metalloprotease which catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro. May play a role in the metabolism of the vasodilator bradykinin., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results describe the organ distribution, developmental change and specific inhibitors of prolidases I and II in the rat., [RefSeq, PubMed]; Xpnpep2 could be a target for heavy metals that impact follicle development by altering the ration of collagens., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.31", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.5.1.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.92", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "3.1.4.50", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.50", "type": "external" }, { "id": "3.4.11.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.9", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0070006 metalloaminopeptidase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0070062 extracellular exosome;GO:0098552 side of membrane", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q99MA2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A8G9-1", "uniprot_id": [ { "id": "ZFY26_RAT", "url": "https://www.uniprot.org/uniprot/D4A8G9", "type": "external" } ], "mass": 284215.0, "length": 2542, "protein_name": "Zinc finger FYVE domain-containing protein 26", "gene_name": "Zfyve26", "organism": "Rat", "refseq_name": "zinc finger FYVE domain-containing protein 26", "refseq_ac": [ { "id": "NP_001101508", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101508", "type": "external" } ], "gene_names_uniprotkb": "Zfyve26", "gene_names_refseq": "Zfyve26", "protein_names_uniprotkb": "Zinc finger FYVE domain-containing protein 26", "protein_names_refseq": "zinc finger FYVE domain-containing protein 26; zinc finger, FYVE domain containing 26", "tax_id": 10116, "disease": "hereditary spastic paraplegia 15 (Disease Ontology:DOID:0110768)", "pathway": " (rno:314265)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Phosphatidylinositol 3-phosphate-binding protein required for the abscission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abscission. May also be required for efficient homologous recombination DNA double-strand break repair (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3ZB97;D3ZBA4", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019901 protein kinase binding;GO:0032266 phosphatidylinositol-3-phosphate binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005813 centrosome;GO:0005764 lysosome;GO:0005770 late endosome;GO:0030496 midbody", "go_biological_process": "GO:0007040 lysosome organization;GO:0000281 mitotic cytokinesis;GO:0000724 double-strand break repair via homologous recombination;GO:1905037 autophagosome organization;GO:0032465 regulation of cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4A8G9-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70566-1", "uniprot_id": [ { "id": "TMOD2_RAT", "url": "https://www.uniprot.org/uniprot/P70566", "type": "external" } ], "mass": 39492.0, "length": 351, "protein_name": "Tropomodulin-2", "gene_name": "Tmod2", "organism": "Rat", "refseq_name": "tropomodulin-2", "refseq_ac": [ { "id": "NP_113801", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113801", "type": "external" } ], "gene_names_uniprotkb": "Tmod2; Ntmod", "gene_names_refseq": "Tmod2", "protein_names_uniprotkb": "Tropomodulin-2; N-Tmod; Neuronal tropomodulin", "protein_names_refseq": "N-Tmod; neuronal tropomodulin; tropomodulin-2", "tax_id": 10116, "disease": "", "pathway": " (rno:58814); (R-RNO-390522)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "22673903;27126680;30301754;30625365;8886980", "class_list": "", "function": "Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; In hippocampal neurons, TMOD2 regulates dendritic arborization., [RefSeq, PubMed]; Tmod1 increases dendritic branching distal from the cell body and the number of filopodia/thin spines. Tmod2 increases dendritic branching proximal to the cell body and the number of mature dendritic spines., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005523 tropomyosin binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0030426 growth cone;GO:0045202 synapse;GO:0005865 striated muscle thin filament;GO:0030016 myofibril", "go_biological_process": "GO:0006936 muscle contraction;GO:0007015 actin filament organization;GO:0007611 learning or memory;GO:0045745 positive regulation of G protein-coupled receptor signaling pathway;GO:0007270 neuron-neuron synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P70566-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63802-1", "uniprot_id": [ { "id": "WEE1_RAT", "url": "https://www.uniprot.org/uniprot/Q63802", "type": "external" } ], "mass": 71496.0, "length": 646, "protein_name": "Wee1-like protein kinase", "gene_name": "Wee1", "organism": "Rat", "refseq_name": "wee1-like protein kinase", "refseq_ac": [ { "id": "NP_001012760", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012760", "type": "external" } ], "gene_names_uniprotkb": "Wee1", "gene_names_refseq": "Wee1", "protein_names_uniprotkb": "Wee1-like protein kinase; 2.7.10.2; Wee1A kinase", "protein_names_refseq": "wee 1 homolog; wee1 tyrosine kinase; wee1-like protein kinase; wee1A kinase", "tax_id": 10116, "disease": "", "pathway": " (rno:308937); (R-RNO-156711); (R-RNO-69202); (R-RNO-69273); (R-RNO-69478); (R-RNO-69656); (R-RNO-75035)", "pathway_count": 7, "publication_count": 7, "publication_id_list": "19444744;20026642;22673903;25659151;26991553;29393594;36591933", "class_list": "", "function": "Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation., [UniProtKB, UniProtKB]; Correlation of Myc Expression with Wee1 Expression by Zanthoxylum acanthopodium in Cervical Carcinoma Histology., [RefSeq, PubMed]; Data suggest that the increase of Wee 1 tyrosine kinase but decrease of early mitotic inhibitor 2 level triggers maturation promoting factor (MPF) destabilization and thereby postovulatory aging-mediated abortive spontaneous egg activation in eggs., [RefSeq, PubMed]; Identified the PI3K/Akt pathway, the cell-cycle regulator Wee1 kinase, and protein kinase C (PKC) as prospective regulatory nodes of neuronal excitability through modulation of the FGF14:Nav1.6 complex. Publication Status: Online-Only, [RefSeq, PubMed]; Rhythmic profiles of the clock gene Wee1 expression within the epithelium from different parts of the rat gut exhibited a difference in phasing., [RefSeq, PubMed]; The regulation of Wee1 by SadA and SadB kinases is essential for the differentiation of polarized neurons., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5EAN3", "ec_number_list": [ { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004672 protein kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0006468 protein phosphorylation;GO:0018108 peptidyl-tyrosine phosphorylation;GO:0051301 cell division;GO:0048812 neuron projection morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q63802-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XID0-1", "uniprot_id": [ { "id": "YIPF5_RAT", "url": "https://www.uniprot.org/uniprot/Q5XID0", "type": "external" } ], "mass": 27903.0, "length": 257, "protein_name": "Protein YIPF5", "gene_name": "Yipf5", "organism": "Rat", "refseq_name": "protein YIPF5", "refseq_ac": [ { "id": "NP_001014172", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014172", "type": "external" } ], "gene_names_uniprotkb": "Yipf5; Yip1a", "gene_names_refseq": "Ac2-256; Yipf5", "protein_names_uniprotkb": "Protein YIPF5; YIP1 family member 5; YPT-interacting protein 1 A", "protein_names_refseq": "YIP1 family member 5; YPT-interacting protein 1 A; protein YIPF5", "tax_id": 10116, "disease": "azoospermia (Disease Ontology:DOID:14227)", "pathway": " (rno:361315)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11489904", "class_list": "", "function": "Plays a role in transport between endoplasmic reticulum and Golgi. In pancreatic beta cells, required to transport proinsulin from endoplasmic reticulum into the Golgi (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0005789 endoplasmic reticulum membrane;GO:0070971 endoplasmic reticulum exit site", "go_biological_process": "GO:0060628 regulation of ER to Golgi vesicle-mediated transport;GO:0015031 protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0007030 Golgi organization;GO:0048280 vesicle fusion with Golgi apparatus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XID0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O55043-1", "uniprot_id": [ { "id": "ARHG7_RAT", "url": "https://www.uniprot.org/uniprot/O55043", "type": "external" } ], "mass": 73140.0, "length": 646, "protein_name": "Rho guanine nucleotide exchange factor 7", "gene_name": "Arhgef7", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Arhgef7; Pak3bp; Pixb", "gene_names_refseq": "", "protein_names_uniprotkb": "Rho guanine nucleotide exchange factor 7; Beta-Pix; PAK-interacting exchange factor beta", "protein_names_refseq": "", "tax_id": 10116, "disease": "cerebrovascular disease (Disease Ontology:DOID:6713)", "pathway": " (rno:114559); (R-RNO-182971); (R-RNO-193648); (R-RNO-3928664); (R-RNO-416482); (R-RNO-8980692); (R-RNO-9013149); (R-RNO-9013406); (R-RNO-9013420); (R-RNO-9013424)", "pathway_count": 10, "publication_count": 6, "publication_id_list": "10896954;16228008;16527308;17652093;22673903;9659915", "class_list": "", "function": "Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions. May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0043008 ATP-dependent protein binding;GO:0043015 gamma-tubulin binding", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0043547 positive regulation of GTPase activity;GO:0007266 Rho protein signal transduction;GO:0007264 small GTPase-mediated signal transduction;GO:0030032 lamellipodium assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O55043-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJP9-1", "uniprot_id": [ { "id": "UBQL1_RAT", "url": "https://www.uniprot.org/uniprot/Q9JJP9", "type": "external" } ], "mass": 62072.0, "length": 582, "protein_name": "Ubiquilin-1", "gene_name": "Ubqln1", "organism": "Rat", "refseq_name": "ubiquilin-1", "refseq_ac": [ { "id": "NP_446199", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446199", "type": "external" } ], "gene_names_uniprotkb": "Ubqln1; Da41; Plic1", "gene_names_refseq": "Da41; Ubqln1", "protein_names_uniprotkb": "Ubiquilin-1; PLIC-1; Protein linking IAP with cytoskeleton 1", "protein_names_refseq": "PLIC-1; protein linking IAP with cytoskeleton 1; ubiquilin-1", "tax_id": 10116, "disease": "amyotrophic lateral sclerosis type 15 (Disease Ontology:DOID:0060206); neurodegenerative disease (Disease Ontology:DOID:1289); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); frontotemporal dementia (Disease Ontology:DOID:9255)", "pathway": " (rno:114590); (R-RNO-8856825)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11528422;12470953;18683930;21852239;22847417;26415648;9303440", "class_list": "", "function": "Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome. Plays a role in the ERAD pathway via its interaction with ER-localized proteins UBXN4, VCP and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome. Plays a role in unfolded protein response (UPR) by attenuating the induction of UPR-inducible genes, DDTI3/CHOP, HSPA5 and PDIA2 during ER stress. Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion. Negatively regulates the TICAM1/TRIF-dependent toll-like receptor signaling pathway by decreasing the abundance of TICAM1 via the autophagic pathway. Promotes the ubiquitination and lysosomal degradation of ORAI1, consequently down-regulating the ORAI1-mediated Ca2+ mobilization (By similarity). Suppresses the maturation and proteasomal degradation of amyloid beta A4 protein (A4) by stimulating the lysine 63 (K63)-linked polyubiquitination. Delays the maturation of A4 by sequestering it in the Golgi apparatus and preventing its transport to the cell surface for subsequent processing (PubMed:22847417). Promotes the surface expression of GABA-A receptors (PubMed:11528422). Ubiquitinates BCL2L10 and thereby stabilizes protein abundance (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; Plic-1 plays an important role in managing epileptic seizures by enhancing seizure inhibition through regulation of GABAARs at synaptic sites., [RefSeq, PubMed]; These results reveal the mechanistic basis by which ubiquilin-1 regulates APP maturation., [RefSeq, PubMed]; Ubiquilin-1 chaperone activity is necessary to regulate the production of APP and its fragments and that diminished ubiquilin-1 levels may contribute to AD pathogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6IN34", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0042802 identical protein binding;GO:0019900 kinase binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0000045 autophagosome assembly;GO:0016236 macroautophagy;GO:0016241 regulation of macroautophagy;GO:0071456 cellular response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9JJP9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VIL3-1", "uniprot_id": [ { "id": "ZWINT_RAT", "url": "https://www.uniprot.org/uniprot/Q8VIL3", "type": "external" } ], "mass": 30142.0, "length": 266, "protein_name": "Outer kinetochore KNL1 complex subunit ZWINT", "gene_name": "Zwint", "organism": "Rat", "refseq_name": "outer kinetochore KNL1 complex subunit ZWINT", "refseq_ac": [ { "id": "NP_671479", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_671479", "type": "external" } ], "gene_names_uniprotkb": "Zwint; Sip30", "gene_names_refseq": "Sip30; Zwint-1; Zwint", "protein_names_uniprotkb": "Outer kinetochore KNL1 complex subunit ZWINT; SNAP25-interacting protein 30; Scoilin; ZW10 interactor; ZW10-interacting protein 1; Zwint-1", "protein_names_refseq": "SNAP25-interacting protein 30; ZW10 interacting protein-1; ZW10 interactor, kinetochore protein; neuroprotective protein 8; outer kinetochore KNL1 complex subunit ZWINT; scoilin", "tax_id": 10116, "disease": "", "pathway": " (rno:257644); (R-RNO-141430); (R-RNO-141444); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-5663220); (R-RNO-68877); (R-RNO-9648025)", "pathway_count": 8, "publication_count": 4, "publication_id_list": "12068081;19723624;22673903;24403136", "class_list": "", "function": "Acts as a component of the outer kinetochore KNL1 complex that serves as a docking point for spindle assembly checkpoint components and mediates microtubule-kinetochore interactions. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules. The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle. Targets the RZZ complex to the kinetochore at prometaphase (By similarity). Recruits MAD2L1 to the kinetochore, but is not required for BUB1B localization. In addition to orienting mitotic chromosomes, it is also essential for alignment of homologous chromosomes during meiotic metaphase I. In meiosis I, required to activate the spindle assembly checkpoint at unattached kinetochores to correct erroneous kinetochore-microtubule attachments (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Our results highlight SIP30 as a target to mediate neuropathic pain-evoked negative emotion, [RefSeq, PubMed]; There is an ERK-responsive region in the rat sip30 promoter. Activation of ERK promotes the recruitment of the transcription factor cyclic AMP-response element-binding protein to the sip30 gene promoter, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q546Y5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030425 dendrite;GO:0016604 nuclear body", "go_biological_process": "GO:0031619 homologous chromosome orientation in meiotic metaphase I;GO:0051301 cell division;GO:0007094 mitotic spindle assembly checkpoint signaling;GO:0051649 establishment of localization in cell;GO:0000070 mitotic sister chromatid segregation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8VIL3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XID5-1", "uniprot_id": [ { "id": "YPEL4_RAT", "url": "https://www.uniprot.org/uniprot/Q5XID5", "type": "external" } ], "mass": 14315.0, "length": 127, "protein_name": "Protein yippee-like 4", "gene_name": "Ypel4", "organism": "Rat", "refseq_name": "protein yippee-like 4", "refseq_ac": [ { "id": "NP_001019540", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019540", "type": "external" } ], "gene_names_uniprotkb": "Ypel4; Ypel", "gene_names_refseq": "Ypel4", "protein_names_uniprotkb": "Protein yippee-like 4", "protein_names_refseq": "protein yippee-like 4", "tax_id": 10116, "disease": "chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515)", "pathway": " (rno:502643)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16641100", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005730 nucleolus", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0008360 regulation of cell shape;GO:0045647 negative regulation of erythrocyte differentiation;GO:0034107 negative regulation of erythrocyte clearance", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XID5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TMD5-1", "uniprot_id": [ { "id": "ZC3HE_RAT", "url": "https://www.uniprot.org/uniprot/Q7TMD5", "type": "external" } ], "mass": 82632.0, "length": 736, "protein_name": "Zinc finger CCCH domain-containing protein 14", "gene_name": "Zc3h14", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Zc3h14; Npuk68", "gene_names_refseq": "", "protein_names_uniprotkb": "Zinc finger CCCH domain-containing protein 14; Nuclear protein UKp83/UKp68", "protein_names_refseq": "", "tax_id": 10116, "disease": "autosomal recessive intellectual developmental disorder (Disease Ontology:DOID:0060308); autosomal recessive intellectual developmental disorder 56 (Disease Ontology:DOID:0081217); intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (rno:192359)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21734151;22673903", "class_list": "", "function": "RNA-binding protein involved in the biogenesis of circular RNAs (circRNAs), which are produced by back-splicing circularization of pre-mRNAs. Acts by binding to both exon-intron boundary and 3'-UTR of pre-mRNAs to promote circRNA biogenesis through dimerization and the association with the spliceosome. Required for spermatogenesis via involvement in circRNA biogenesis. Regulates the pre-mRNA processing of ATP5MC1; preventing its degradation. Also binds the poly(A) tail of mRNAs; controlling poly(A) length in neuronal cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TSK6;Q99NC1", "ec_number_list": [], "go_molecular_function": "GO:0036002 pre-mRNA binding;GO:0008270 zinc ion binding;GO:0003730 mRNA 3'-UTR binding;GO:0008143 poly(A) binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0032839 dendrite cytoplasm;GO:1904115 axon cytoplasm", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0048255 mRNA stabilization;GO:0043488 regulation of mRNA stability;GO:0160091 spliceosome-depend formation of circular RNA", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7TMD5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0CG51-1", "uniprot_id": [ { "id": "UBB_RAT", "url": "https://www.uniprot.org/uniprot/P0CG51", "type": "external" } ], "mass": 34369.0, "length": 305, "protein_name": "Polyubiquitin-B", "gene_name": "Ubb", "organism": "Rat", "refseq_name": "polyubiquitin-B", "refseq_ac": [ { "id": "NP_001396021", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001396021", "type": "external" } ], "gene_names_uniprotkb": "Ubb", "gene_names_refseq": "Ubb", "protein_names_uniprotkb": "Polyubiquitin-B", "protein_names_refseq": "polyubiquitin-B", "tax_id": 10116, "disease": "", "pathway": " (rno:192255); (R-RNO-110312); (R-RNO-110314); (R-RNO-110320); (R-RNO-1169091); (R-RNO-1234176); (R-RNO-1253288); (R-RNO-1295596); (R-RNO-1358803); (R-RNO-168638); (R-RNO-174048); (R-RNO-174084); (R-RNO-174113); (R-RNO-174154); (R-RNO-174178); (R-RNO-174184); (R-RNO-179409); (R-RNO-182971); (R-RNO-187577); (R-RNO-195253); (R-RNO-201681); (R-RNO-202424); (R-RNO-205043); (R-RNO-209543); (R-RNO-209560); (R-RNO-2122948); (R-RNO-2173788); (R-RNO-2173791); (R-RNO-2173795); (R-RNO-2173796); (R-RNO-2467813); (R-RNO-2559580); (R-RNO-2559582); (R-RNO-2559585); (R-RNO-2565942); (R-RNO-2672351); (R-RNO-2871837); (R-RNO-3134975); (R-RNO-349425); (R-RNO-3769402); (R-RNO-382556); (R-RNO-445989); (R-RNO-450302); (R-RNO-450321); (R-RNO-450408); (R-RNO-4608870); (R-RNO-4641257); (R-RNO-4641258); (R-RNO-4641263); (R-RNO-5205685); (R-RNO-532668); (R-RNO-5357905); (R-RNO-5357956); (R-RNO-5358346); (R-RNO-5607761); (R-RNO-5607764); (R-RNO-5610780); (R-RNO-5610785); (R-RNO-5632684); (R-RNO-5654726); (R-RNO-5654727); (R-RNO-5654732); (R-RNO-5654733); (R-RNO-5655862); (R-RNO-5656121); (R-RNO-5656169); (R-RNO-5658442); (R-RNO-5668541); (R-RNO-5675221); (R-RNO-5675482); (R-RNO-5676590); (R-RNO-5684264); (R-RNO-5685942); (R-RNO-5687128); (R-RNO-5689603); (R-RNO-5689877); (R-RNO-5689880); (R-RNO-5689896); (R-RNO-5689901); (R-RNO-5693537); (R-RNO-5693565); (R-RNO-5696394); (R-RNO-5696395); (R-RNO-5696397); (R-RNO-5696400); (R-RNO-6781823); (R-RNO-6782135); (R-RNO-6782210); (R-RNO-6783310); (R-RNO-6804756); (R-RNO-6804757); (R-RNO-6804760); (R-RNO-6807004); (R-RNO-68867); (R-RNO-68949); (R-RNO-69017); (R-RNO-69231); (R-RNO-69481); (R-RNO-69541); (R-RNO-69601); (R-RNO-75815); (R-RNO-8849469); (R-RNO-8852276); (R-RNO-8854050); (R-RNO-8856825); (R-RNO-8856828); (R-RNO-8863795); (R-RNO-8866427); (R-RNO-8866652); (R-RNO-8866654); (R-RNO-8939236); (R-RNO-8941858); (R-RNO-8948747); (R-RNO-8948751); (R-RNO-8951664); (R-RNO-901032); (R-RNO-9013507); (R-RNO-9020702); (R-RNO-9033241); (R-RNO-909733); (R-RNO-912631); (R-RNO-917729); (R-RNO-917937); (R-RNO-936440); (R-RNO-936964); (R-RNO-937039); (R-RNO-937041); (R-RNO-937042); (R-RNO-937072); (R-RNO-9645460); (R-RNO-9646399); (R-RNO-9648002); (R-RNO-9664873); (R-RNO-9705462); (R-RNO-975144); (R-RNO-975163); (R-RNO-9755511); (R-RNO-9758274); (R-RNO-9762114); (R-RNO-9766229); (R-RNO-9770562); (R-RNO-9824878); (R-RNO-983168); (R-RNO-9861718); (R-RNO-9929356); (R-RNO-9929491); (R-RNO-9931269); (R-RNO-9931295); (R-RNO-9932298); (R-RNO-9954709); (R-RNO-9954716); (R-RNO-9958810); (R-RNO-9958825)", "pathway_count": 153, "publication_count": 5, "publication_id_list": "19844237;20737472;29475881;8018730;8031840", "class_list": "", "function": "Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling., [UniProtKB, UniProtKB]; Mn(2+)-induced SNAT3 protein degradation and the dysregulation of Gln homeostasis in primary astrocyte cultures proceeds through the ubiquitin-mediated proteolytic system, [RefSeq, PubMed]; We conclude that activation of caspase-3 might be upstream of UBB(+1) formation and that excessive UBB(+1) could bind to beta secretase, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P02248;P02249;P02250;P62989;Q29120;Q63446;Q91887;Q91888", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0031386 protein tag activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0043025 neuronal cell body;GO:0043005 neuron projection", "go_biological_process": "GO:0047497 mitochondrion transport along microtubule;GO:0007144 female meiosis I;GO:0060612 adipose tissue development;GO:0048812 neuron projection morphogenesis;GO:0051881 regulation of mitochondrial membrane potential", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P0CG51-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8WCF8-1", "uniprot_id": [ { "id": "TPRGL_RAT", "url": "https://www.uniprot.org/uniprot/A8WCF8", "type": "external" } ], "mass": 29844.0, "length": 266, "protein_name": "Tumor protein p63-regulated gene 1-like protein", "gene_name": "Tprg1l", "organism": "Rat", "refseq_name": "tumor protein p63-regulated gene 1-like protein isoform 1", "refseq_ac": [ { "id": "NP_001103788", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103788", "type": "external" } ], "gene_names_uniprotkb": "Tprg1l; Mover", "gene_names_refseq": "Tprg1l; mover", "protein_names_uniprotkb": "Tumor protein p63-regulated gene 1-like protein; Mossy fiber terminal-associated vertebrate-specific presynaptic protein", "protein_names_refseq": "mossy-fiber terminal-associated vertebrate-specific presynaptic protein; tumor protein p63-regulated gene 1-like protein isoform 1; tumor protein p63-regulated gene 1-like protein", "tax_id": 10116, "disease": "", "pathway": " (rno:687090)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17869247;22673903;23723986;26212709", "class_list": "", "function": "Mover expression in certain subsets of synapses negatively regulates synaptic release probability in the calyx of Held., [RefSeq, PubMed]; Mover may act in concert with generally expressed scaffolding proteins in distinct sets of presynaptic terminals, [RefSeq, PubMed]; Presynaptic protein involved in the synaptic transmission tuning. Regulates synaptic release probability by decreasing the calcium sensitivity of release., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098850 extrinsic component of synaptic vesicle membrane;GO:0044305 calyx of Held;GO:0005737 cytoplasm;GO:0048786 presynaptic active zone", "go_biological_process": "GO:0050805 negative regulation of synaptic transmission;GO:0051966 regulation of synaptic transmission, glutamatergic;GO:0033173 calcineurin-NFAT signaling cascade;GO:0016081 synaptic vesicle docking;GO:2000300 regulation of synaptic vesicle exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A8WCF8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80U96-1", "uniprot_id": [ { "id": "XPO1_RAT", "url": "https://www.uniprot.org/uniprot/Q80U96", "type": "external" } ], "mass": 123039.0, "length": 1071, "protein_name": "Exportin-1", "gene_name": "Xpo1", "organism": "Rat", "refseq_name": "exportin-1", "refseq_ac": [ { "id": "NP_445942", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445942", "type": "external" } ], "gene_names_uniprotkb": "Xpo1; Crm1", "gene_names_refseq": "Xpo1; exp1", "protein_names_uniprotkb": "Exportin-1; Chromosome region maintenance 1 protein homolog; Exp1", "protein_names_refseq": "chromosome region maintenance 1 protein homolog; exportin 1 (CRM1, yeast, homolog); exportin 1, CRM1 homolog; exportin-1", "tax_id": 10116, "disease": "colorectal carcinoma (Disease Ontology:DOID:0080199); stomach cancer (Disease Ontology:DOID:10534); pancreatic cancer (Disease Ontology:DOID:1793); gastric adenocarcinoma (Disease Ontology:DOID:3717); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); extrahepatic bile duct carcinoma (Disease Ontology:DOID:4682); stomach carcinoma (Disease Ontology:DOID:5517); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:85252); (R-RNO-141430); (R-RNO-141444); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-3769402); (R-RNO-450520); (R-RNO-5663220); (R-RNO-5687128); (R-RNO-68877); (R-RNO-69273); (R-RNO-9634638); (R-RNO-9648025); (R-RNO-9707616); (R-RNO-9856649)", "pathway_count": 15, "publication_count": 3, "publication_id_list": "11689633;16641100;22673903", "class_list": "", "function": "Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase Ran in its active GTP-bound form. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0019904 protein domain specific binding;GO:0031267 small GTPase binding;GO:0005049 nuclear export signal receptor activity;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0010824 regulation of centrosome duplication;GO:0000055 ribosomal large subunit export from nucleus;GO:0071401 cellular response to triglyceride;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006406 mRNA export from nucleus", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q80U96-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R1Z0-1", "uniprot_id": [ { "id": "VDAC3_RAT", "url": "https://www.uniprot.org/uniprot/Q9R1Z0", "type": "external" } ], "mass": 30798.0, "length": 283, "protein_name": "Non-selective voltage-gated ion channel VDAC3", "gene_name": "Vdac3", "organism": "Rat", "refseq_name": "non-selective voltage-gated ion channel VDAC3", "refseq_ac": [ { "id": "NP_112645", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112645", "type": "external" } ], "gene_names_uniprotkb": "Vdac3", "gene_names_refseq": "Vdac3", "protein_names_uniprotkb": "Non-selective voltage-gated ion channel VDAC3; Outer mitochondrial membrane protein porin 3; VDAC-3; rVDAC3", "protein_names_refseq": "VDAC-3; mitochondrial voltage dependent anion channel 3; non-selective voltage-gated ion channel VDAC3; outer mitochondrial membrane protein porin 3; rVDAC3; voltage-dependent anion-selective channel protein 3", "tax_id": 10116, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (rno:83532); (R-RNO-5205685); (R-RNO-5689880)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10998068;17478130;19423663;34502162;9714728", "class_list": "", "function": "Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane. Forms a high-conducting channel with a stable open state and a voltage-induced closure with a mild preference for anions over cations. Involved in male fertility and sperm mitochondrial sheath formation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6GSZ1;Q9ESR2;Q9JI31;Q9WTU2", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0005244 voltage-gated monoatomic ion channel activity;GO:0015288 porin activity;GO:0008308 voltage-gated monoatomic anion channel activity;GO:0000166 nucleotide binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0016020 membrane;GO:0008021 synaptic vesicle;GO:0046930 pore complex", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007612 learning;GO:0007268 chemical synaptic transmission;GO:0001662 behavioral fear response;GO:0007270 neuron-neuron synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9R1Z0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PQS2-1", "uniprot_id": [ { "id": "ZN365_RAT", "url": "https://www.uniprot.org/uniprot/Q5PQS2", "type": "external" } ], "mass": 46968.0, "length": 408, "protein_name": "Protein ZNF365", "gene_name": "Zfp365; Znf365", "organism": "Rat", "refseq_name": "protein ZNF365", "refseq_ac": [ { "id": "NP_001020316", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020316", "type": "external" } ], "gene_names_uniprotkb": "Zfp365; Znf365; DBZ; Zfp365", "gene_names_refseq": "Zfp365; Znf365", "protein_names_uniprotkb": "Protein ZNF365; DISC1-binding zinc-finger protein", "protein_names_refseq": "DISC1-binding zinc-finger protein; protein ZNF365", "tax_id": 10116, "disease": "uric acid nephrolithiasis (Disease Ontology:DOID:580)", "pathway": " (rno:499425)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17389905;22673903;24481677", "class_list": "", "function": "Involved in the positive regulation of oligodendrocyte differentiation during postnatal growth (PubMed:24481677). Involved in the morphogenesis of basket cells in the somatosensory cortex during embryogenesis. Involved in dendritic arborization, morphogenesis of spine density dendrite, and establishment of postsynaptic dendrite density in cortical pyramidal neurons (By similarity). Involved in the regulation of neurogenesis. Negatively regulates neurite outgrowth. Involved in homologous recombination (HR) repair pathway. Required for proper resolution of DNA double-strand breaks (DSBs) by HR. Is required for recovery of stalled replication forks, and directly contributes to genomic stability. Interacts with PARP1 and mediates MRE11-dependent DNA end resection during replication fork recovery. Contributes to genomic stability by preventing telomere dysfunction (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005813 centrosome", "go_biological_process": "GO:0048714 positive regulation of oligodendrocyte differentiation;GO:0140059 dendrite arborization;GO:0010977 negative regulation of neuron projection development;GO:0000723 telomere maintenance;GO:0010975 regulation of neuron projection development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5PQS2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91ZQ0-1", "uniprot_id": [ { "id": "VMP1_RAT", "url": "https://www.uniprot.org/uniprot/Q91ZQ0", "type": "external" } ], "mass": 45901.0, "length": 406, "protein_name": "Vacuole membrane protein 1", "gene_name": "Vmp1", "organism": "Rat", "refseq_name": "vacuole membrane protein 1", "refseq_ac": [ { "id": "NP_620194", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620194", "type": "external" } ], "gene_names_uniprotkb": "Vmp1", "gene_names_refseq": "Tmem49; Vmp1", "protein_names_uniprotkb": "Vacuole membrane protein 1", "protein_names_refseq": "transmembrane protein 49; vacuole membrane protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:192129)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11785947;12649568;15367889;17940279;21173155", "class_list": "", "function": "Phospholipid scramblase involved in lipid homeostasis and membrane dynamics processes (By similarity). Has phospholipid scramblase activity toward cholesterol and phosphatidylserine, as well as phosphatidylethanolamine and phosphatidylcholine (By similarity). Required for autophagosome formation: participates in early stages of autophagosome biogenesis at the endoplasmic reticulum (ER) membrane by reequilibrating the leaflets of the ER as lipids are extracted by ATG2 (ATG2A or ATG2B) to mediate autophagosome assembly (By similarity). Regulates ATP2A2 activity to control ER-isolation membrane contacts for autophagosome formation (PubMed:17940279). In addition to autophagy, involved in other processes in which phospholipid scramblase activity is required (By similarity). Modulates ER contacts with lipid droplets, mitochondria and endosomes (By similarity). Plays an essential role in formation of cell junctions (By similarity). Upon stress such as bacterial and viral infection, promotes formation of cytoplasmic vacuoles followed by cell death (PubMed:11785947, PubMed:12649568, PubMed:15367889). Involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis (PubMed:11785947, PubMed:12649568, PubMed:15367889)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]; VMP1 expression may be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis., [RefSeq, PubMed]; Zymophagy, a novel selective autophagy pathway mediated by VMP1-USP9x-p62, prevents pancreatic cell death., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" } ], "go_molecular_function": "GO:0017128 phospholipid scramblase activity", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0034329 cell junction assembly;GO:0042953 lipoprotein transport;GO:0098609 cell-cell adhesion;GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q91ZQ0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P7B7-1", "uniprot_id": [ { "id": "ZFY27_RAT", "url": "https://www.uniprot.org/uniprot/Q6P7B7", "type": "external" } ], "mass": 44948.0, "length": 404, "protein_name": "Protrudin", "gene_name": "Zfyve27", "organism": "Rat", "refseq_name": "protrudin", "refseq_ac": [ { "id": "NP_954535", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_954535", "type": "external" } ], "gene_names_uniprotkb": "Zfyve27", "gene_names_refseq": "Zfyve27", "protein_names_uniprotkb": "Protrudin; Zinc finger FYVE domain-containing protein 27", "protein_names_refseq": "protrudin; zinc finger FYVE domain-containing protein 27; zinc finger, FYVE domain containing 27", "tax_id": 10116, "disease": "", "pathway": " (rno:309376)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17082457;19289470;25855459;34348158", "class_list": "", "function": "A kinesin 1-protrudin complex mediates AMPA receptor synaptic removal during long-term depression., [RefSeq, PubMed]; Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport. Promotes axonal elongation and contributes to the establishment of neuronal cell polarity. Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner. Contributes to both the formation and stabilization of the tubular ER network. Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections. Acts as an adapter protein that facilitates the interaction of KIF5A with VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 and the ZFYVE27-KIF5A complex contributes to the transport of these proteins in neurons. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a KIF5A/B-dependent manner., [UniProtKB, UniProtKB, UniProtKB]; Molecular tethering protein, which plays a role in the formation of membrane contact sites between the endoplasmic reticulum and late endosomes/lysosomes (PubMed:17082457, PubMed:25855459). Promotes neurite formation by tethering endosomes to the endoplasmic reticulum membrane: interacts with Rab7-positive late endosomes, acting as a bridge to form endoplasmic reticulum membrane-endosome contact sites (PubMed:25855459). Acts in cooperation with vesicle-associated membrane protein-associated protein (VAPA or VAPB), thereby facilitating loading of the endosome membrane with KIF5, which is required for movement of the endosomes along microtubules in the plus-end direction (By similarity). Also associates with Rab11-positive recycling endosomes, facilitating exocytosis and membrane expansion (By similarity). Contributes to both the formation and stabilization of the tubular endoplasmic reticulum network (By similarity). Involved in endoplasmic reticulum morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; Protrudin regulates Rab11-dependent membrane recycling to promote the directional membrane trafficking required for neurite formation [protrudin], [RefSeq, PubMed]; VAP-A is an important regulator both of the subcellular localization of protrudin and of its ability to stimulate neurite outgrowth., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0032584 growth cone membrane;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0030424 axon", "go_biological_process": "GO:0031175 neuron projection development;GO:0072659 protein localization to plasma membrane;GO:0016192 vesicle-mediated transport;GO:0045773 positive regulation of axon extension;GO:0048011 neurotrophin TRK receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6P7B7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z327-1", "uniprot_id": [ { "id": "SYNPO_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z327", "type": "external" } ], "mass": 99986.0, "length": 931, "protein_name": "Synaptopodin", "gene_name": "Myoz3; Synpo", "organism": "Rat", "refseq_name": "synaptopodin", "refseq_ac": [ { "id": "NP_067727", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067727", "type": "external" } ], "gene_names_uniprotkb": "Myoz3; Synpo; Myoz3", "gene_names_refseq": "Synpo", "protein_names_uniprotkb": "Synaptopodin", "protein_names_refseq": "synaptopodin", "tax_id": 10116, "disease": "chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (rno:60324); (rno:689274)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "11595771;15340146;22673903;26840625;28657654;29393594;30744518;31371487;34502162;9314539", "class_list": "", "function": "Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity., [UniProtKB, PubMed]; Myosin V regulates synaptopodin clustering and localization in the dendrites of hippocampal neurons. Publication Status: Online-Only, [RefSeq, PubMed]; The study provides evidence of a novel role for the co-chaperone BAG3 in synapses. In cooperation with SYNPO, it functions as part of a surveillance complex that facilitates the autophagic clearance of MAPT p-Ser262, and possibly other MAPT species at the post-synapse., [RefSeq, PubMed]; Using single particle tracking we have identified a specific effect of synaptopodin on the diffusion of metabotropic mGluR5 receptors in the spine neck. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005829 cytosol;GO:0005923 bicellular tight junction;GO:0014069 postsynaptic density", "go_biological_process": "GO:0032233 positive regulation of actin filament bundle assembly;GO:0008542 visual learning;GO:0048169 regulation of long-term neuronal synaptic plasticity;GO:0051492 regulation of stress fiber assembly;GO:1905355 spine apparatus assembly", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9Z327-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35147-1", "uniprot_id": [ { "id": "BAD_RAT", "url": "https://www.uniprot.org/uniprot/O35147", "type": "external" } ], "mass": 22228.0, "length": 205, "protein_name": "Bcl2-associated agonist of cell death", "gene_name": "Bad", "organism": "Rat", "refseq_name": "bcl2-associated agonist of cell death isoform 4", "refseq_ac": [ { "id": "NP_073189", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073189", "type": "external" } ], "gene_names_uniprotkb": "Bad", "gene_names_refseq": "Bad_v1; Bad_v2; Bad", "protein_names_uniprotkb": "Bcl2-associated agonist of cell death; BAD; Bcl-2-binding component 6; Bcl-xL/Bcl-2-associated death promoter; Bcl2 antagonist of cell death", "protein_names_refseq": "Bcl2-antagonist of cell death; bcl-2 associated death agonist; bcl-2-binding component 6; bcl-xL/Bcl-2-associated death promoter; bcl2 antagonist of cell death; bcl2-associated agonist of cell death isoform 4; bcl2-associated death promoter", "tax_id": 10116, "disease": "chronic pancreatitis (Disease Ontology:DOID:0051065); Parkinsonism (Disease Ontology:DOID:0080855); traumatic brain injury (Disease Ontology:DOID:0081292); prostate carcinoma (Disease Ontology:DOID:10286); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); prostatic hypertrophy (Disease Ontology:DOID:11132); endometrial cancer (Disease Ontology:DOID:1380); hypothyroidism (Disease Ontology:DOID:1459); breast cancer (Disease Ontology:DOID:1612); glaucoma (Disease Ontology:DOID:1686); pancreatic cancer (Disease Ontology:DOID:1793); impotence (Disease Ontology:DOID:1875); colon cancer (Disease Ontology:DOID:219); brain ischemia (Disease Ontology:DOID:2316); acute kidney failure (Disease Ontology:DOID:3021); high grade glioma (Disease Ontology:DOID:3070); middle cerebral artery infarction (Disease Ontology:DOID:3525); intermittent claudication (Disease Ontology:DOID:3669); pulmonary fibrosis (Disease Ontology:DOID:3770); lung non-small cell carcinoma (Disease Ontology:DOID:3908); macular degeneration (Disease Ontology:DOID:4448); renal cell carcinoma (Disease Ontology:DOID:4450); osteoarthritis (Disease Ontology:DOID:8398); type 2 diabetes mellitus (Disease Ontology:DOID:9352); diabetic neuropathy (Disease Ontology:DOID:9743); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:64639); (R-RNO-111447); (R-RNO-111453); (R-RNO-193648)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "10195903;10597268;11161472;17998337;20410435;22673903;27690136;30911955;31784847;34315852;9369453;9535132", "class_list": "", "function": "Chrysin prevents apoptosis by upregulating the Bcl-2 mRNA expression and downregulating the pro-apoptotic (Bax, Bad) mRNAs in 3-nitropropionic acid induced behavioral despair/mitochondrial dysfunction/striatal apoptosis., [RefSeq, PubMed]; It was found that NGF promoted phosphorylation of Akt and Bad, which is TrkA dependent. However, K252a and MK-2206 (TrkA and Akt inhibitor, respectively) suppressed the anti-apoptosis of NGF, indicating the protective effect of NGF on BMSCs apoptosis via a novel Akt/Bad pathway., [RefSeq, PubMed]; On day 14 after hyperthermia changes in synthesis led to a decrease in Bcl-2/Bad index, which attested to weakening of the antiapoptotic defense and activation of oocyte apoptosis by the mitochondrial pathway., [RefSeq, PubMed]; Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways., [UniProtKB]; Super-resolution microscopy reveals that Na(+)/K(+)-ATPase signaling protects against glucose-induced apoptosis by deactivating Bad. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 28, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O70256;Q9JHX1", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0019901 protein kinase binding;GO:0008289 lipid binding;GO:0071889 14-3-3 protein binding;GO:0030346 protein phosphatase 2B binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol;GO:0097138 BAD-BCL-2 complex", "go_biological_process": "GO:0007283 spermatogenesis;GO:0008283 cell population proliferation;GO:0032024 positive regulation of insulin secretion;GO:0034201 response to oleic acid;GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "O35147-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QY02-1", "uniprot_id": [ { "id": "YTDC1_RAT", "url": "https://www.uniprot.org/uniprot/Q9QY02", "type": "external" } ], "mass": 85902.0, "length": 738, "protein_name": "YTH domain-containing protein 1", "gene_name": "Ythdc1", "organism": "Rat", "refseq_name": "YTH domain-containing protein 1 isoform 7", "refseq_ac": [ { "id": "NP_001424136", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001424136", "type": "external" } ], "gene_names_uniprotkb": "Ythdc1; Yt521", "gene_names_refseq": "Yt521; Ythdc1", "protein_names_uniprotkb": "YTH domain-containing protein 1; RA301-binding protein; Splicing factor YT521", "protein_names_refseq": "RA301-binding protein; YTH domain containing 1; YTH domain-containing protein 1 isoform 7; YTH domain-containing protein 1; putative splicing factor YT521; splicing factor YT521-B", "tax_id": 10116, "disease": "", "pathway": " (rno:170956); (R-RNO-9930044)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10564280;10973987;11118435;19282290;22673903;25389274;33188203;36443649;39407279;9473574", "class_list": "", "function": "METTL3 mediates m6A modification of lncRNA CRNDE to promote ATG10 expression and improve brain ischemia/reperfusion injury through YTHDC1. Publication Status: Online-Only, [RefSeq, PubMed]; Methyltransferase-like 3 modulates visceral hypersensitivity through regulating the nuclear export of circKcnk9 in YTHDC1-dependent manner., [RefSeq, PubMed]; Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:25389274). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:25389274). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (By similarity). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (By similarity). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (By similarity). May also regulate alternative splice site selection (PubMed:10564280, PubMed:9473574). Also involved in nuclear export of m6A-containing mRNAs via interaction with SRSF3: interaction with SRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (By similarity). Involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs (By similarity). Also recognizes and binds m6A on other RNA molecules (By similarity). Involved in random X inactivation mediated by Xist RNA: recognizes and binds m6A-containing Xist and promotes transcription repression activity of Xist (By similarity). Also recognizes and binds m6A-containing single-stranded DNA (By similarity). Involved in germline development: required for spermatogonial development in males and oocyte growth and maturation in females, probably via its role in alternative splicing (By similarity). Independently of its N6-methyladenosine-containing RNA reader activity, it regulates PPARG stability by preventing its interaction with the E3 ubiquitin ligase ARIH2, thereby protecting it from ubiquitin-mediated proteasomal degradation and contributing to brown adipose tissue (BAT) development and energy homeostasis (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, UniProtKB]; Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing., [UniProtKB, UniProtKB, UniProtKB]; YTHDC1 mitigates ischemic stroke by promoting Akt phosphorylation through destabilizing PTEN mRNA. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3V690;O54729", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:1990247 N6-methyladenosine-containing RNA reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0016604 nuclear body", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0006406 mRNA export from nucleus;GO:0007283 spermatogenesis;GO:0050873 brown fat cell differentiation;GO:0010608 post-transcriptional regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9QY02-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQV6-1", "uniprot_id": [ { "id": "TPP1_RAT", "url": "https://www.uniprot.org/uniprot/Q9EQV6", "type": "external" } ], "mass": 61332.0, "length": 563, "protein_name": "Tripeptidyl-peptidase 1", "gene_name": "Tpp1", "organism": "Rat", "refseq_name": "tripeptidyl-peptidase 1 precursor", "refseq_ac": [ { "id": "NP_112647", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112647", "type": "external" } ], "gene_names_uniprotkb": "Tpp1; Cln2", "gene_names_refseq": "Cln2; Tpp1", "protein_names_uniprotkb": "Tripeptidyl-peptidase 1; 3.4.14.9; TPP-1; TPP-I; Tripeptidyl aminopeptidase; Tripeptidyl-peptidase I", "protein_names_refseq": "TPP-1; TPP-I; ceroid-lipofuscinosis, neuronal 2; tripeptidyl aminopeptidase; tripeptidyl-peptidase 1 precursor; tripeptidyl-peptidase I", "tax_id": 10116, "disease": "autosomal recessive spinocerebellar ataxia 7 (Disease Ontology:DOID:0080059); neuronal ceroid lipofuscinosis 2 (Disease Ontology:DOID:0110726)", "pathway": " (rno:83534)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "24090084;24841565;25636608;27263093;31533043;38843836;9659384", "class_list": "", "function": "A High-Content Screen Identifies TPP1 and Aurora B as Regulators of Axonal Mitochondrial Transport., [RefSeq, PubMed]; Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; TPPI activity was strictly regulated following hypoxic stress in the rat brain., [RefSeq, PubMed]; These findings also suggest that TPP I is involved in the general turnover of chemotransmitters between glomus cells and sensory nerve endings which emphasizes its importance for chemoreception under hypoxic conditions., [RefSeq, PubMed]; We describe a molecular mechanism in which inducible interactions of noncanonical RNA motif structures with targeting factor heterogeneous nuclear ribonucleoprotein (hnRNP) A2 form the basis for activity-dependent dendritic RNA targeting with CLN2., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 8, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0046872 metal ion binding;GO:0008240 tripeptidyl-peptidase activity;GO:0042277 peptide binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0045121 membrane raft;GO:0055037 recycling endosome;GO:0005764 lysosome;GO:0042470 melanosome", "go_biological_process": "GO:0006508 proteolysis;GO:0007399 nervous system development;GO:0030855 epithelial cell differentiation;GO:0050885 neuromuscular process controlling balance;GO:0043171 peptide catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9EQV6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2VCX1-1", "uniprot_id": [ { "id": "TIPRL_RAT", "url": "https://www.uniprot.org/uniprot/A2VCX1", "type": "external" } ], "mass": 31225.0, "length": 271, "protein_name": "TIP41-like protein", "gene_name": "Tiprl", "organism": "Rat", "refseq_name": "TIP41-like protein", "refseq_ac": [ { "id": "NP_001103137", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103137", "type": "external" } ], "gene_names_uniprotkb": "Tiprl", "gene_names_refseq": "RGD1310442; Tiprl", "protein_names_uniprotkb": "TIP41-like protein", "protein_names_refseq": "CG9578-like; TIP41, TOR signaling pathway regulator-like; TIP41, TOR signalling pathway regulator-like; TIP41-like protein", "tax_id": 10116, "disease": "", "pathway": " (rno:360869)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. Acts as a negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AX phosphorylated on Ser-140 (gamma-H2AX). May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004864 protein phosphatase inhibitor activity;GO:0072542 protein phosphatase activator activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0031929 TOR signaling;GO:0000077 DNA damage checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2VCX1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70441-1", "uniprot_id": [ { "id": "SYN3_RAT", "url": "https://www.uniprot.org/uniprot/O70441", "type": "external" } ], "mass": 63349.0, "length": 579, "protein_name": "Synapsin-3", "gene_name": "Syn3", "organism": "Rat", "refseq_name": "synapsin-3", "refseq_ac": [ { "id": "NP_058805", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058805", "type": "external" } ], "gene_names_uniprotkb": "Syn3", "gene_names_refseq": "Syn3", "protein_names_uniprotkb": "Synapsin-3; Synapsin III", "protein_names_refseq": "regulated by Ca+2; synapsin-3-like; synapsin-3", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (rno:29130); (R-RNO-181429); (R-RNO-212676)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "11867766;22673903;25843720;9593663", "class_list": "", "function": "May be involved in the regulation of neurotransmitter release and synaptogenesis. Binds ATP with high affinity and ADP with a lower affinity. This is consistent with a catalytic role of the C-domain in which ADP would be dissociated by cellular ATP after bound ATP was hydrolyzed., [UniProtKB]; We show that SynIII phosphorylation at the CDK5 site is induced by activation of the semaphorin-3A (Sema3A) pathway, which is implicated in migration and orientation of cortical pyramidal neurons, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098850 extrinsic component of synaptic vesicle membrane;GO:0014069 postsynaptic density;GO:0045202 synapse;GO:0030672 synaptic vesicle membrane", "go_biological_process": "GO:0097091 synaptic vesicle clustering;GO:0099504 synaptic vesicle cycle;GO:0050808 synapse organization;GO:0007269 neurotransmitter secretion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O70441-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TPK1-1", "uniprot_id": [ { "id": "UHRF1_RAT", "url": "https://www.uniprot.org/uniprot/Q7TPK1", "type": "external" } ], "mass": 87449.0, "length": 774, "protein_name": "E3 ubiquitin-protein ligase UHRF1", "gene_name": "Uhrf1", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase UHRF1 isoform 2", "refseq_ac": [ { "id": "NP_001380775", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001380775", "type": "external" } ], "gene_names_uniprotkb": "Uhrf1; Ac2-121", "gene_names_refseq": "Ac2-121; Np95; Uhrf1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase UHRF1; 2.3.2.27; Liver regeneration-related protein LRRG126; Ubiquitin-like PHD and RING finger domain-containing protein 1; Ubiquitin-like-containing PHD and RING finger domains protein 1", "protein_names_refseq": "E3 ubiquitin-protein ligase UHRF1 isoform 2; E3 ubiquitin-protein ligase UHRF1; RING-type E3 ubiquitin transferase UHRF1; liver regeneration-related protein LRRG126; nuclear protein 95; ubiquitin-like PHD and RING finger domain-containing protein 1; ubiquitin-like, containing PHD and RING finger domains, 1; ubiquitin-like-containing PHD and RING finger domains protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:316129)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17065439;22673903", "class_list": "", "function": "E3 ubiquitin-protein ligase that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Plays a key role in DNA methylation inheritance by promoting recruitment of DNMT1 to hemimethylated DNA and ensure faithful propagation of the DNA methylation patterns through DNA replication. Acts both as a histone reader and writer: specifically recognizes and binds (1) hemimethylated DNA at replication forks and (2) histone H3 trimethylated at 'Lys-9' and unmethylated at 'Arg-2' (H3K9me3 and H3R2me0, respectively), thereby activating its E3 ubiquitin-protein ligase activity. UHRF1 then mediates histone H3 'Lys-18' monoubiquitination (H3K18ub), a docking site for DNMT1, leading to DNMT1 recruitment and replication-coupled DNA methylation maintenance. Also mediates histone H3 'Lys-14' and 'Lys-23' ubiquitination (H3K14ub and H3K23ub) at lower level. Histone ubiquitin ligase activity also stimulates the methyltransferase activity of SUV39H1 and/or SUV39H2, promoting accumulation of H3K9me3 histone mark to reinformce heterochromatin state. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Plays a role in DNA repair by cooperating with UHRF2 to ensure recruitment of FANCD2 to interstrand cross-links (ICLs) leading to FANCD2 activation. Also ubiquitinates non-histone proteins, such as histone H3, KIF11 and PML. Acts as a critical player of proper spindle architecture by catalyzing the 'Lys-63'-linked ubiquitination of KIF11, thereby controlling KIF11 localization on the spindle., [UniProtKB, UniProtKB]; Multi domain E3 ubiquitin ligase that also plays a role in DNA methylation and histone modifications., [UniProtKB, UniProtKB, UniProtKB]; UHRF1 inhibits the late phase of oligodendrocyte differentiation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4FZR4", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0003676 nucleic acid binding;GO:0061630 ubiquitin protein ligase activity;GO:0000987 cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016363 nuclear matrix;GO:0000785 chromatin;GO:0000791 euchromatin", "go_biological_process": "GO:0050678 regulation of epithelial cell proliferation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7TPK1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15389-1", "uniprot_id": [ { "id": "SCN5A_RAT", "url": "https://www.uniprot.org/uniprot/P15389", "type": "external" } ], "mass": 227367.0, "length": 2019, "protein_name": "Sodium channel protein type 5 subunit alpha", "gene_name": "Scn5a", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Scn5a", "gene_names_refseq": "", "protein_names_uniprotkb": "Sodium channel protein type 5 subunit alpha; Sodium channel protein cardiac muscle subunit alpha; Sodium channel protein type V subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.5", "protein_names_refseq": "", "tax_id": 10116, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); familial atrial fibrillation (Disease Ontology:DOID:0050650); generalized epilepsy with febrile seizures plus (Disease Ontology:DOID:0060170); Dravet syndrome (Disease Ontology:DOID:0080422); Brugada syndrome 1 (Disease Ontology:DOID:0110218); dilated cardiomyopathy 1E (Disease Ontology:DOID:0110433); long QT syndrome 3 (Disease Ontology:DOID:0110646); progressive familial heart block type IA (Disease Ontology:DOID:0111074); generalized epilepsy with febrile seizures plus 2 (Disease Ontology:DOID:0111294); sick sinus syndrome (Disease Ontology:DOID:13884); epilepsy (Disease Ontology:DOID:1826); brain ischemia (Disease Ontology:DOID:2316); long QT syndrome (Disease Ontology:DOID:2843); congestive heart failure (Disease Ontology:DOID:6000); sudden infant death syndrome (Disease Ontology:DOID:9007)", "pathway": " (rno:25665)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "15579534;18386309;19376164;19661460;21454685;21617128;22673903;24497506;2554302;26039939;29530619;31866066;9417050", "class_list": "", "function": "Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Pore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes (By similarity). Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient (By similarity). The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:24497506, PubMed:31866066). Nav1.5 is the predominant sodium channel expressed in myocardial cells and it is responsible for the initial upstroke of the action potential in cardiac myocytes, thereby initiating the heartbeat (By similarity). Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2 (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 11, "predicted_n_glycosites": 10, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 15, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "Q925G6", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0086060 voltage-gated sodium channel activity involved in AV node cell action potential;GO:0086061 voltage-gated sodium channel activity involved in bundle of His cell action potential;GO:0086063 voltage-gated sodium channel activity involved in SA node cell action potential;GO:0005516 calmodulin binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0030424 axon", "go_biological_process": "GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization;GO:0086048 membrane depolarization during bundle of His cell action potential;GO:0003360 brainstem development;GO:0003231 cardiac ventricle development;GO:0019228 neuronal action potential", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P15389-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQE1-1", "uniprot_id": [ { "id": "SENP2_RAT", "url": "https://www.uniprot.org/uniprot/Q9EQE1", "type": "external" } ], "mass": 67252.0, "length": 588, "protein_name": "Sentrin-specific protease 2", "gene_name": "Senp2", "organism": "Rat", "refseq_name": "sentrin-specific protease 2", "refseq_ac": [ { "id": "NP_076479", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076479", "type": "external" } ], "gene_names_uniprotkb": "Senp2", "gene_names_refseq": "Axam; Senp2", "protein_names_uniprotkb": "Sentrin-specific protease 2; 3.4.22.-; Axam; Axin-associating molecule; Sentrin/SUMO-specific protease SENP2", "protein_names_refseq": "Axin-associating molecule; SUMO/sentrin specific peptidase 2; SUMO/sentrin specific protease 2; Sumo1/sentrin/SMT3 specific peptidase 2; sentrin-specific protease 2; sentrin/SUMO-specific protease SENP2", "tax_id": 10116, "disease": "", "pathway": " (rno:78973); (R-RNO-3065679)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10944533;11997515;29146736;29535048;34947973", "class_list": "", "function": "Data suggest that SENP2 in hepatic stellate cells is involved in regulation of apoptosis in these cells and in development/reversion of liver fibrosis (here, carbon tetrachloride-induced liver fibrosis)., [RefSeq, PubMed]; Protease that catalyzes two essential functions in the SUMO pathway (By similarity). The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins (By similarity). The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein (By similarity). May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway (PubMed:10944533, PubMed:11997515). Deconjugates SUMO2 from MTA1 (By similarity). Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB (By similarity). Acts as a regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS and STING1 during the late phase of viral infection (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed]; Quantitative high-throughput screening identifies cytoprotective molecules that enhance SUMO conjugation via the inhibition of SUMO-specific protease (SENP)2., [RefSeq, PubMed]; Regulation of Serotonin 1A Receptor SUMOylation by SENP2 and PIASxalpha. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" } ], "go_molecular_function": "GO:0016929 deSUMOylase activity;GO:0019904 protein domain specific binding;GO:0070139 SUMO-specific endopeptidase activity;GO:0008234 cysteine-type peptidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005643 nuclear pore;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031965 nuclear membrane", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0006508 proteolysis;GO:0007507 heart development;GO:0015031 protein transport;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9EQE1-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28573-1", "uniprot_id": [ { "id": "SC6A7_RAT", "url": "https://www.uniprot.org/uniprot/P28573", "type": "external" } ], "mass": 71091.0, "length": 637, "protein_name": "Sodium-dependent proline transporter", "gene_name": "Slc6a7", "organism": "Rat", "refseq_name": "sodium-dependent proline transporter", "refseq_ac": [ { "id": "NP_446448", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446448", "type": "external" } ], "gene_names_uniprotkb": "Slc6a7; Prot", "gene_names_refseq": "Prot; Slc6a7", "protein_names_uniprotkb": "Sodium-dependent proline transporter; Solute carrier family 6 member 7", "protein_names_refseq": "L-proline transporter; sodium-dependent proline transporter-like; sodium-dependent proline transporter; solute carrier family 6 (neurotransmitter transporter), member 7; solute carrier family 6 (neurotransmitter transporter, L-proline), member 7", "tax_id": 10116, "disease": "", "pathway": " (rno:117100); (R-RNO-442660); (R-RNO-71288)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10414958;1350201;16458270;16641100;22673903", "class_list": "", "function": "Brain specific sodium (and chloride)-dependent proline transporter (PubMed:10414958). Terminates the action of proline by its high affinity sodium-dependent reuptake into presynaptic terminals (Probable)., [UniProtKB, PubMed]; Strong L-proline-like immunoreactivity was confined to several groups of neurons in the arcuate nucleus (n) and supraoptic n and area postrema and the nerve fiber of brainstem., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015193 L-proline transmembrane transporter activity;GO:0005298 proline:sodium symporter activity;GO:0046872 metal ion binding;GO:0015293 symporter activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0045202 synapse;GO:0030672 synaptic vesicle membrane;GO:0042734 presynaptic membrane", "go_biological_process": "GO:0015824 proline transport;GO:0035524 proline transmembrane transport;GO:0035725 sodium ion transmembrane transport;GO:0030163 protein catabolic process;GO:0006836 neurotransmitter transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P28573-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88420-1", "uniprot_id": [ { "id": "SCN8A_RAT", "url": "https://www.uniprot.org/uniprot/O88420", "type": "external" } ], "mass": 225159.0, "length": 1978, "protein_name": "Sodium channel protein type 8 subunit alpha", "gene_name": "Scn8a", "organism": "Rat", "refseq_name": "sodium channel protein type 8 subunit alpha", "refseq_ac": [ { "id": "NP_062139", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062139", "type": "external" } ], "gene_names_uniprotkb": "Scn8a", "gene_names_refseq": "Scn8a", "protein_names_uniprotkb": "Sodium channel protein type 8 subunit alpha; NaCh6; PN4; Peripheral nerve protein type 4; Sodium channel 6; Sodium channel protein type VIII subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.6", "protein_names_refseq": "Na+ channel; PN4; naCh6; peripheral nerve protein type 4; sodium channel 6; sodium channel protein type 8 subunit alpha; sodium channel protein type VIII subunit alpha; sodium channel, voltage gated, type VIII, alpha subunit; sodium channel, voltage-gated, type 8, alpha polypeptide; sodium channel, voltage-gated, type 8, alpha subunit; sodium channel, voltage-gated, type VIII, alpha polypeptide; voltage-gated sodium channel subunit alpha Nav1.6", "tax_id": 10116, "disease": "early infantile epileptic encephalopathy (Disease Ontology:DOID:0050709); generalized epilepsy with febrile seizures plus (Disease Ontology:DOID:0060170); Dravet syndrome (Disease Ontology:DOID:0080422); developmental and epileptic encephalopathy 13 (Disease Ontology:DOID:0080445); benign familial infantile seizures 5 (Disease Ontology:DOID:0081118); generalized epilepsy with febrile seizures plus 2 (Disease Ontology:DOID:0111294); epilepsy (Disease Ontology:DOID:1826); pancreatitis (Disease Ontology:DOID:4989); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (rno:29710)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "15282281;22673903;24497506;27905510;28655185;30699332;36359772;37572007;9603190", "class_list": "", "function": "Data strongly suggest that voltage-gated sodium channel subunit alpha Nav1.6 ( Nav1.6) plays an indispensable role in the peripheral pain hypersensitivity induced by BmK I., [RefSeq, PubMed]; Increased expression of Nav1.6 of reactive astrocytes in the globus pallidus is closely associated with motor deficits in a model of Parkinson's disease., [RefSeq, PubMed]; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Pore-forming subunit of a voltage-gated sodium channel complex assuming opened or closed conformations in response to the voltage difference across membranes and through which sodium ions selectively pass along their electrochemical gradient. Contributes to neuronal excitability by regulating action potential threshold and propagation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]; Study found that knockdown of either NaV1.6 or NaVbeta4 reduced pain behaviors and sensory neuron hyperexcitability in the chronic compression dorsal rook ganglia model of low back pain., [RefSeq, PubMed]; To clarify the exact expression patterns of Nav1.6 during epileptogenesis, we examined the expression of Nav1.6 at protein and mRNA levels in two distinct models of temporal lobe epilepsy including a post-status epilepticus model induced by kainic acid intrahippocampal injection and a kindling model evoked by pentylenetetrazole. Publication Status: Online-Only, [RefSeq, PubMed]; Upregulation of Nav1.6 Mediated by the p38 MAPK Pathway in the Dorsal Root Ganglia Contributes to Cancer-Induced Bone Pain in Rats. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 8, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "O88421", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0031402 sodium ion binding;GO:0005248 voltage-gated sodium channel activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon", "go_biological_process": "GO:0007626 locomotory behavior;GO:0019228 neuronal action potential;GO:0001508 action potential;GO:0019233 sensory perception of pain;GO:0042552 myelination", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O88420-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4G056-1", "uniprot_id": [ { "id": "TYDP1_RAT", "url": "https://www.uniprot.org/uniprot/Q4G056", "type": "external" } ], "mass": 68632.0, "length": 609, "protein_name": "Tyrosyl-DNA phosphodiesterase 1", "gene_name": "Tdp1", "organism": "Rat", "refseq_name": "tyrosyl-DNA phosphodiesterase 1", "refseq_ac": [ { "id": "NP_001026827", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026827", "type": "external" } ], "gene_names_uniprotkb": "Tdp1", "gene_names_refseq": "Tdp1", "protein_names_uniprotkb": "Tyrosyl-DNA phosphodiesterase 1; 3.1.4.-; Tyr-DNA phosphodiesterase 1", "protein_names_refseq": "tyr-DNA phosphodiesterase 1; tyrosyl-DNA phosphodiesterase 1", "tax_id": 10116, "disease": "spinocerebellar ataxia with axonal neuropathy 1 (Disease Ontology:DOID:0090115)", "pathway": " (rno:314380); (R-RNO-5693571)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0003690 double-stranded DNA binding;GO:0004527 exonuclease activity;GO:0003697 single-stranded DNA binding;GO:0017005 3'-tyrosyl-DNA phosphodiesterase activity;GO:0008081 phosphoric diester hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0006281 DNA repair;GO:0006302 double-strand break repair;GO:0000012 single strand break repair", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4G056-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q01986-1", "uniprot_id": [ { "id": "MP2K1_RAT", "url": "https://www.uniprot.org/uniprot/Q01986", "type": "external" } ], "mass": 43465.0, "length": 393, "protein_name": "Dual specificity mitogen-activated protein kinase kinase 1", "gene_name": "Map2k1", "organism": "Rat", "refseq_name": "dual specificity mitogen-activated protein kinase kinase 1", "refseq_ac": [ { "id": "NP_113831", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113831", "type": "external" } ], "gene_names_uniprotkb": "Map2k1; Mek1; Prkmk1", "gene_names_refseq": "Map2k1; Mek1", "protein_names_uniprotkb": "Dual specificity mitogen-activated protein kinase kinase 1; 2.7.12.2; ERK activator kinase 1; MAP kinase kinase 1; MAPK/ERK kinase 1; MAPKK 1; MEK 1", "protein_names_refseq": "ERK activator kinase 1; MAP kinase kinase 1; MAP kinase/Erk kinase 1; MAPK/ERK kinase 1; MAPKK 1; dual specificity mitogen-activated protein kinase kinase 1", "tax_id": 10116, "disease": "cardiofaciocutaneous syndrome (Disease Ontology:DOID:0060233); RASopathy (Disease Ontology:DOID:0080690); cardiofaciocutaneous syndrome 3 (Disease Ontology:DOID:0111462); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); prostate adenocarcinoma (Disease Ontology:DOID:2526); high grade glioma (Disease Ontology:DOID:3070); lung adenocarcinoma (Disease Ontology:DOID:3910); ovarian carcinoma (Disease Ontology:DOID:4001); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); melorheostosis (Disease Ontology:DOID:4253); renal cell carcinoma (Disease Ontology:DOID:4450); small intestine adenocarcinoma (Disease Ontology:DOID:4906); cataract (Disease Ontology:DOID:83)", "pathway": " (rno:170851); (R-RNO-110056); (R-RNO-170968); (R-RNO-445144); (R-RNO-5673000); (R-RNO-5674135); (R-RNO-5674499)", "pathway_count": 7, "publication_count": 21, "publication_id_list": "10769026;11226259;12876277;14993270;15520807;19177150;19319189;19565474;21779493;22673903;28975447;30206251;30876692;36642184;7565670;8034665;8380494;8406028;8462694;9733512;9779990", "class_list": "", "function": "Biotin labeling of cell surface proteins from cardiomyocytes overexpressing ADAP1 revealed that it reduces the surface expression of b1-integrin, an effect that is strongly potentiated by Mek1ca overexpression. Publication Status: Online-Only, [RefSeq, PubMed]; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (By similarity). Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis., [UniProtKB, PubMed, UniProtKB, PubMed]; TSG-6 can inhibit the inflammatory response of transplanted vein grafts in rats and reduce vascular injury by downregulation of P38 and JNK signaling pathway., [RefSeq, PubMed]; Used a constitutively active MEK1 gene (CaMEK) transfection strategy to investigate whether CaMEK provides a protective effect against apoptosis and autophagy induced by hydrogen peroxide (H2O2) in neonatal rat cardiac ventricular cardiomyocytes (NCMs) and the underlying mechanisms, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 14, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5EBD5", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0030295 protein kinase activator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:2000641 regulation of early endosome to late endosome transport;GO:0030878 thyroid gland development;GO:0046579 positive regulation of Ras protein signal transduction;GO:0045933 positive regulation of muscle contraction;GO:2001171 positive regulation of ATP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q01986-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V893-1", "uniprot_id": [ { "id": "ZN335_RAT", "url": "https://www.uniprot.org/uniprot/G3V893", "type": "external" } ], "mass": 145536.0, "length": 1336, "protein_name": "Zinc finger protein 335", "gene_name": "Zfp335; Znf335", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Zfp335; Znf335; Zfp335", "gene_names_refseq": "", "protein_names_uniprotkb": "Zinc finger protein 335; NIF-1; NRC-interacting factor 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "primary autosomal recessive microcephaly 10 (Disease Ontology:DOID:0070294)", "pathway": "", "pathway_count": 0, "publication_count": 4, "publication_id_list": "12215545;18180299;22673903;29393594", "class_list": "", "function": "Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters (By similarity). Enhances ligand-dependent transcriptional activation by nuclear hormone receptors (By similarity). Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST (By similarity). Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8CIV9", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0035097 histone methyltransferase complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0048812 neuron projection morphogenesis;GO:0007420 brain development;GO:0040029 epigenetic regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "G3V893-1", "record_type": "protein", "filter_code": "0000000.0000110.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2GUZ1-1", "uniprot_id": [ { "id": "UBP4_RAT", "url": "https://www.uniprot.org/uniprot/B2GUZ1", "type": "external" } ], "mass": 108373.0, "length": 961, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 4", "gene_name": "C8h3orf62; Usp4", "organism": "Rat", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 4", "refseq_ac": [ { "id": "NP_001128484", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001128484", "type": "external" } ], "gene_names_uniprotkb": "C8h3orf62; Usp4; LOC498675; Usp4", "gene_names_refseq": "Usp4", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 4; 3.4.19.12; Deubiquitinating enzyme 4; Ubiquitin thioesterase 4; Ubiquitin-specific-processing protease 4", "protein_names_refseq": "deubiquitinating enzyme 4; ubiquitin carboxyl-terminal hydrolase 4; ubiquitin specific peptidase 4 (proto-oncogene); ubiquitin specific protease 4 (proto-oncogene); ubiquitin thioesterase 4; ubiquitin-specific-processing protease 4", "tax_id": 10116, "disease": "", "pathway": " (rno:290864); (rno:498675); (R-RNO-5357786); (R-RNO-5357905); (R-RNO-5357956); (R-RNO-5689880)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "16339847;22673903;27114249;28755289;29393594", "class_list": "", "function": "Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes., [UniProtKB, UniProtKB, UniProtKB]; Deubiquitinating enzyme that removes conjugated ubiquitin from target proteins. Deubiquitinates PDPK1. Deubiquitinates TRIM21. Deubiquitinates receptor ADORA2A which increases the amount of functional receptor at the cell surface. Deubiquitinates HAS2. Deubiquitinates RHEB in response to EGF signaling, promoting mTORC1 signaling. Deubiquitinates MAVS leading to maintain MAVS protein stability, resulting in increased production of type I interferons (IFN-I) and enhanced antiviral innate immune responses against viral infections. May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3. This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6.U5 snRNP. May also play a role in the regulation of quality control in the ER., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; USP4 may be involved in neuronal apoptosis after intracerebral hemorrhage., [RefSeq, PubMed]; USP4 was expressed in microglia, but its expression decreased after spinal cord injury., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0031685 adenosine receptor binding;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0000244 spliceosomal tri-snRNP complex assembly;GO:0031647 regulation of protein stability", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "B2GUZ1-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZF42-1", "uniprot_id": [ { "id": "SENP7_RAT", "url": "https://www.uniprot.org/uniprot/D3ZF42", "type": "external" } ], "mass": 116872.0, "length": 1037, "protein_name": "Sentrin-specific protease 7", "gene_name": "Impg2; Senp7", "organism": "Rat", "refseq_name": "sentrin-specific protease 7", "refseq_ac": [ { "id": "NP_001099358", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099358", "type": "external" } ], "gene_names_uniprotkb": "Impg2; Senp7; Impg2; Senp7; Susp2", "gene_names_refseq": "Senp7", "protein_names_uniprotkb": "Sentrin-specific protease 7; 3.4.22.-; SUMO-1-specific protease 2; Sentrin/SUMO-specific protease SENP7", "protein_names_refseq": "SUMO-1-specific protease 2; SUMO1/sentrin specific peptidase 7; SUMO1/sentrin specific protease 7; Sumo1/sentrin/SMT3 specific peptidase 7; sentrin-specific protease 7; sentrin/SUMO-specific protease SENP7", "tax_id": 10116, "disease": "acute promyelocytic leukemia (Disease Ontology:DOID:0060318)", "pathway": " (rno:288167)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "Chondroitin sulfate- and hyaluronan-binding proteoglycan involved in the organization of interphotoreceptor matrix; may participate in the maturation and maintenance of the light-sensitive photoreceptor outer segment. Binds heparin., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Protease that acts as a positive regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS. Desumoylation of CGAS promotes DNA-binding activity of CGAS, subsequent oligomerization and activation (By similarity). Deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO proteins to their mature forms (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0070139 SUMO-specific endopeptidase activity;GO:0008201 heparin binding;GO:0008234 cysteine-type peptidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0099523 presynaptic cytosol;GO:0099524 postsynaptic cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0016926 protein desumoylation;GO:0140374 antiviral innate immune response;GO:0007601 visual perception;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZF42-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62764-1", "uniprot_id": [ { "id": "YBOX3_RAT", "url": "https://www.uniprot.org/uniprot/Q62764", "type": "external" } ], "mass": 38852.0, "length": 361, "protein_name": "Y-box-binding protein 3", "gene_name": "Ybx3", "organism": "Rat", "refseq_name": "Y-box-binding protein 3", "refseq_ac": [ { "id": "NP_114185", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114185", "type": "external" } ], "gene_names_uniprotkb": "Ybx3; Csda; Dbpa; Yb2", "gene_names_refseq": "Csda; Dbpa; Yb2; Ybx3", "protein_names_uniprotkb": "Y-box-binding protein 3; Cold shock domain-containing protein A; DNA-binding protein A; Muscle Y-box protein YB2; RYB-A; Y-box-binding protein A", "protein_names_refseq": "DNA-binding protein A; RYB-A; Y-box-binding protein 3; Y-box-binding protein A; cold shock domain protein A; cold shock domain-containing protein A; muscle Y-box protein YB2", "tax_id": 10116, "disease": "", "pathway": " (rno:83807)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22673903;29393348;8029009", "class_list": "", "function": "Binds to the GM-CSF promoter. Seems to act as a repressor. Also binds to full-length mRNA and to short RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression (By similarity)., [UniProtKB]; These results suggest that Csda expression in alveolar epithelial cells type II decreases under hyperoxia conditions, which promotes transdifferentiation and inhibits proliferation of alveolar epithelial cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q63748", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0043021 ribonucleoprotein complex binding;GO:0003676 nucleic acid binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005923 bicellular tight junction;GO:0045202 synapse", "go_biological_process": "GO:2000767 positive regulation of cytoplasmic translation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q62764-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33436-1", "uniprot_id": [ { "id": "MMP2_RAT", "url": "https://www.uniprot.org/uniprot/P33436", "type": "external" } ], "mass": 74149.0, "length": 662, "protein_name": "72 kDa type IV collagenase", "gene_name": "Mmp2", "organism": "Rat", "refseq_name": "72 kDa type IV collagenase precursor", "refseq_ac": [ { "id": "NP_112316", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112316", "type": "external" } ], "gene_names_uniprotkb": "Mmp2", "gene_names_refseq": "Mmp2", "protein_names_uniprotkb": "72 kDa type IV collagenase; 3.4.24.24; 72 kDa gelatinase; Gelatinase A; MMP-2; Matrix metalloproteinase-2", "protein_names_refseq": "72 KDa type IV collagenase; 72 kDa gelatinase; 72 kDa type IV collagenase precursor; MMP-2; gelatinase A; matrix metalloproteinase-2", "tax_id": 10116, "disease": "pterygium (Disease Ontology:DOID:0002116); cardiomyopathy (Disease Ontology:DOID:0050700); stroke (Disease Ontology:DOID:0051061); ductal carcinoma in situ (Disease Ontology:DOID:0060074); atrial fibrillation (Disease Ontology:DOID:0060224); aortic valve disease 2 (Disease Ontology:DOID:0080334); COVID-19 (Disease Ontology:DOID:0080600); Sweet syndrome (Disease Ontology:DOID:0080746); immunoglobulin light chain amyloidosis (Disease Ontology:DOID:0080933); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); traumatic brain injury (Disease Ontology:DOID:0081292); Sturge-Weber syndrome (Disease Ontology:DOID:0111563); keratoconus (Disease Ontology:DOID:10126); prostate cancer (Disease Ontology:DOID:10283); adrenoleukodystrophy (Disease Ontology:DOID:10588); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); renal hypertension (Disease Ontology:DOID:1073); hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); intracranial aneurysm (Disease Ontology:DOID:10941); cholesteatoma of middle ear (Disease Ontology:DOID:10964); urinary bladder cancer (Disease Ontology:DOID:11054); polycystic ovary syndrome (Disease Ontology:DOID:11612); myopia (Disease Ontology:DOID:11830); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); primary biliary cholangitis (Disease Ontology:DOID:12236); leiomyoma (Disease Ontology:DOID:127); dilated cardiomyopathy (Disease Ontology:DOID:12930); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); Behcet's disease (Disease Ontology:DOID:13241); temporal arteritis (Disease Ontology:DOID:13375); cholestasis (Disease Ontology:DOID:13580); thoracic aortic aneurysm (Disease Ontology:DOID:14004); Marfan syndrome (Disease Ontology:DOID:14323); alcohol use disorder (Disease Ontology:DOID:1574); retinal vein occlusion (Disease Ontology:DOID:1727); squamous cell carcinoma (Disease Ontology:DOID:1749); pancreatic cancer (Disease Ontology:DOID:1793); atherosclerosis (Disease Ontology:DOID:1936); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); colon adenocarcinoma (Disease Ontology:DOID:234); arteriosclerosis (Disease Ontology:DOID:2349); hemangioma (Disease Ontology:DOID:255); transitional cell carcinoma (Disease Ontology:DOID:2671); pseudoxanthoma elasticum (Disease Ontology:DOID:2738); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); endometriosis (Disease Ontology:DOID:289); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); HTLV-1-associated myelopathy/tropical spastic paraparesis (Disease Ontology:DOID:321); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); carotid artery disease (Disease Ontology:DOID:3407); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); heart valve disease (Disease Ontology:DOID:4079); macular degeneration (Disease Ontology:DOID:4448); renal cell carcinoma (Disease Ontology:DOID:4450); cholangiocarcinoma (Disease Ontology:DOID:4947); liver cirrhosis (Disease Ontology:DOID:5082); stomach carcinoma (Disease Ontology:DOID:5517); proteinuria (Disease Ontology:DOID:576); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); conjunctivitis (Disease Ontology:DOID:6195); abdominal aortic aneurysm (Disease Ontology:DOID:7693); end stage renal disease (Disease Ontology:DOID:783); periodontitis (Disease Ontology:DOID:824); osteoarthritis (Disease Ontology:DOID:8398); pyoderma gangrenosum (Disease Ontology:DOID:8553); cholesteatoma (Disease Ontology:DOID:869); vascular dementia (Disease Ontology:DOID:8725); skin melanoma (Disease Ontology:DOID:8923); diabetic retinopathy (Disease Ontology:DOID:8947); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); cutaneous leishmaniasis (Disease Ontology:DOID:9111); colorectal cancer (Disease Ontology:DOID:9256); ocular hypertension (Disease Ontology:DOID:9282); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary embolism (Disease Ontology:DOID:9477); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (rno:81686); (R-RNO-1442490); (R-RNO-1474228); (R-RNO-1592389); (R-RNO-381426); (R-RNO-3928665); (R-RNO-9009391)", "pathway_count": 7, "publication_count": 7, "publication_id_list": "26479776;36988559;37607602;37643020;37700592;38388415;7916617", "class_list": "", "function": "HNF4A Negatively Regulated Posterior Capsular Opacification via Transcriptional Inhibition of MMP2., [RefSeq, PubMed]; Knockout of Matrix Metalloproteinase 2 Opposes Hypertension- and Diabetes-induced Nephropathy. Publication Status: Online-Only, [RefSeq, PubMed]; PEX, the C-terminal non-catalytic fragment of MMP2, possesses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrin alpha-v/beta3 on the surface of blood vessels (By similarity)., [UniProtKB]; S-nitrosylation of EMMPRIN influences the migration of HSCs and MMP activity in liver fibrosis., [RefSeq, PubMed]; SPOCK2 modulates neuropathic pain by interacting with MT1-MMP to regulate astrocytic MMP-2 activation in rats with chronic constriction injury. Publication Status: Online-Only, [RefSeq, PubMed]; Type I collagen proteolysis by matrix metalloproteinase-2 contributes to focal adhesion kinase activation and vascular smooth muscle cell proliferation in the aorta in early hypertension., [RefSeq, PubMed]; Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 2, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 83, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "P97581;Q6GMM9", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.4.24.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.7", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.4.24.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.34", "type": "external" }, { "id": "3.4.24.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.17", "type": "external" }, { "id": "3.4.24.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.22", "type": "external" }, { "id": "3.4.24.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.24", "type": "external" }, { "id": "3.4.24.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.23", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.4.24.80", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.80", "type": "external" }, { "id": "3.4.24.65", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.65", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005886 plasma membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0006508 proteolysis;GO:0006979 response to oxidative stress;GO:0007162 negative regulation of cell adhesion;GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P33436-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WU34-1", "uniprot_id": [ { "id": "SEPT3_RAT", "url": "https://www.uniprot.org/uniprot/Q9WU34", "type": "external" } ], "mass": 40598.0, "length": 358, "protein_name": "Neuronal-specific septin-3", "gene_name": "Septin3", "organism": "Rat", "refseq_name": "neuronal-specific septin-3", "refseq_ac": [ { "id": "NP_062248", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062248", "type": "external" } ], "gene_names_uniprotkb": "Septin3; Sept3", "gene_names_refseq": "Sep3; Sept3; Septin3", "protein_names_uniprotkb": "Neuronal-specific septin-3; G-septin; P40", "protein_names_refseq": "G-septin alpha; P40; alternatively spliced; neuronal-specific septin-3", "tax_id": 10116, "disease": "", "pathway": " (rno:56003)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10744683;15107017;15485489;18466330", "class_list": "", "function": "Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential)., [UniProtKB]; Filament-forming cytoskeletal GTPase. May play a role in cytokinesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Sept3 is a neurone-specific developmentally regulated protein highly enriched in nerve terminals which supports a secretory role in synaptic vesicle recycling., [RefSeq, PubMed]; Septin 3 localizes in the membrane microdomains of the synaptic plasma membrane in adult brain and may have important roles in the membrane dynamics of neurons., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9R245;Q9WU35", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005940 septin ring;GO:0015630 microtubule cytoskeleton;GO:0042734 presynaptic membrane;GO:0098793 presynapse;GO:0031105 septin complex", "go_biological_process": "GO:0008104 intracellular protein localization;GO:0061640 cytoskeleton-dependent cytokinesis;GO:0140247 protein catabolic process at presynapse", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9WU34-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WUF4-1", "uniprot_id": [ { "id": "VAMP8_RAT", "url": "https://www.uniprot.org/uniprot/Q9WUF4", "type": "external" } ], "mass": 11320.0, "length": 100, "protein_name": "Vesicle-associated membrane protein 8", "gene_name": "Vamp8", "organism": "Rat", "refseq_name": "vesicle-associated membrane protein 8", "refseq_ac": [ { "id": "NP_114015", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114015", "type": "external" } ], "gene_names_uniprotkb": "Vamp8", "gene_names_refseq": "Vamp8", "protein_names_uniprotkb": "Vesicle-associated membrane protein 8; EDB; Endobrevin; VAMP-8", "protein_names_refseq": "EDB; VAMP-8; endobrevin; vesicle-associated membrane protein 8", "tax_id": 10116, "disease": "", "pathway": " (rno:83730); (R-RNO-1236974); (R-RNO-199992); (R-RNO-432720); (R-RNO-432722); (R-RNO-6798695); (R-RNO-8856825); (R-RNO-8856828)", "pathway_count": 8, "publication_count": 11, "publication_id_list": "10336434;10982406;11029036;11208143;11786915;12414999;12737809;27402227;28242757;33641252;9614193", "class_list": "", "function": "Acute inhibition of VAMP8-mediated secretion during pancreatitis triggers intracellular trypsin accumulation and loss of the early endosomal compartment, [RefSeq, PubMed]; SNAREs (soluble N-ethylmaleimide-sensitive factor-attachment protein receptors) are essential proteins for intracellular membrane fusion. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four-helix bundle whose assembly releases energy that drives membrane fusion. The core SNARE complex typically consists of four alpha-helical domains, three from target membrane SNAREs (t-SNAREs) and one from a vesicle SNARE (v-SNARE). VAMP8 is a v-SNARE that forms a SNARE complex with the t-SNARE STX11 and SNAP23. This SNARE complex plays a critical role in the regulated exocytosis of cytotoxic granules by natural killer (NK) cells and cytotoxic T-lymphocytes. VAMP8 plays a role in autophagy where it controls organelle-organelle membrane fusion through a VAMP8, SNAP29 and STX17 SNARE complex that mediates the fusion of autophagosome and lysososome membranes (By similarity). VAMP8 is required for dense-granule secretion in platelets (By similarity). Also plays a role in regulated enzyme secretion in pancreatic acinar cells (By similarity). Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells (PubMed:12737809). Involved in the homotypic fusion of early and late endosomes (PubMed:10982406, PubMed:11029036). Also participates in the activation of type I interferon antiviral response through a TRIM6-dependent mechanism (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t-SNARE complex. Also required for dense-granule secretion in platelets. Also plays a role in regulated enzyme secretion in pancreatic acinar cells. Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells. Involved in the homotypic fusion of early and late endosomes. Also participates in the activation of type I interferon antiviral response through a TRIM6-dependent mechanism., [UniProtKB, UniProtKB]; The authors took a proteomics approach using a PKCB knockout mast cell model and found that the key mast cell secretory protein VAMP8 becomes phosphorylated by PKC at multiple residues in the SNARE domain., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019869 chloride channel inhibitor activity;GO:0019905 syntaxin binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0042588 zymogen granule;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0097352 autophagosome maturation;GO:1902278 positive regulation of pancreatic amylase secretion;GO:0015031 protein transport;GO:0030100 regulation of endocytosis;GO:0051607 defense response to virus", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9WUF4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EPU7-1", "uniprot_id": [ { "id": "Z354C_RAT", "url": "https://www.uniprot.org/uniprot/Q9EPU7", "type": "external" } ], "mass": 64193.0, "length": 560, "protein_name": "Zinc finger protein 354C", "gene_name": "Zfp354c; Znf354c", "organism": "Rat", "refseq_name": "zinc finger protein 354C", "refseq_ac": [ { "id": "NP_076478", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076478", "type": "external" } ], "gene_names_uniprotkb": "Zfp354c; Znf354c; Zfp354c", "gene_names_refseq": "Aj18; Zfn354c; Zfp354c; Znf354c", "protein_names_uniprotkb": "Zinc finger protein 354C; Protein AJ18", "protein_names_refseq": "zinc finger protein 354C; zinc finger transcription factor", "tax_id": 10116, "disease": "", "pathway": " (rno:78972); (R-RNO-212436)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "11278774;22009963", "class_list": "", "function": "Glucocorticoids may induce femoral head osteonecrosis by down-regulating Runx2/Osterix mRNA and up-regulating AJ18 mRNA., [RefSeq, PubMed]; Transcriptional repressor that inhibits endothelial angiogenic sprouting (By similarity). Suppresses osteogenic effects of RUNX2 and may be involved in osteoblastic differentiation (PubMed:11278774). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity)., [UniProtKB, UniProtKB, PubMed]; Transcriptional repressor that inhibits endothelial angiogenic sprouting. Suppresses osteogenic effects of RUNX2 and may be involved in osteoblastic differentiation. Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0031965 nuclear membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:1903671 negative regulation of sprouting angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9EPU7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63537-1", "uniprot_id": [ { "id": "SYN2_RAT", "url": "https://www.uniprot.org/uniprot/Q63537", "type": "external" } ], "mass": 63457.0, "length": 586, "protein_name": "Synapsin-2", "gene_name": "Syn2", "organism": "Rat", "refseq_name": "synapsin-2 isoform 1", "refseq_ac": [ { "id": "NP_001029192", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029192", "type": "external" } ], "gene_names_uniprotkb": "Syn2", "gene_names_refseq": "Syn2", "protein_names_uniprotkb": "Synapsin-2; Synapsin II", "protein_names_refseq": "synapsin-2 isoform 1; synapsin-2", "tax_id": 10116, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); autism spectrum disorder (Disease Ontology:DOID:0060041); epilepsy (Disease Ontology:DOID:1826); colon adenocarcinoma (Disease Ontology:DOID:234); lung non-small cell carcinoma (Disease Ontology:DOID:3908); systemic scleroderma (Disease Ontology:DOID:418); renal carcinoma (Disease Ontology:DOID:4451); schizophrenia (Disease Ontology:DOID:5419); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (rno:29179); (R-RNO-181429); (R-RNO-212676)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10571231;11867766;19609639;20657584;22673903;2506642", "class_list": "", "function": "Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradrenaline secretion by sympathetic neurons (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Study provided high sequence coverage information on synapsin 2a and 2b in mouse and rat, revealing highest identity between the species; phosphorylation sites were determined, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 13, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9Z1H0", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0048306 calcium-dependent protein binding;GO:0008092 cytoskeletal protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098850 extrinsic component of synaptic vesicle membrane;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0043195 terminal bouton", "go_biological_process": "GO:0097091 synaptic vesicle clustering;GO:0099504 synaptic vesicle cycle;GO:0050808 synapse organization;GO:0046928 regulation of neurotransmitter secretion;GO:0007269 neurotransmitter secretion", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q63537-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q00900-1", "uniprot_id": [ { "id": "ZEP2_RAT", "url": "https://www.uniprot.org/uniprot/Q00900", "type": "external" } ], "mass": 267426.0, "length": 2437, "protein_name": "Human immunodeficiency virus type I enhancer-binding protein 2 homolog", "gene_name": "Hivep2", "organism": "Rat", "refseq_name": "human immunodeficiency virus type I enhancer-binding protein 2 homolog", "refseq_ac": [ { "id": "NP_077051", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077051", "type": "external" } ], "gene_names_uniprotkb": "Hivep2; Agie-bp1; Mibp1", "gene_names_refseq": "Hivep2; MIBP1", "protein_names_uniprotkb": "Human immunodeficiency virus type I enhancer-binding protein 2 homolog; Angiotensinogen gene-inducible enhancer-binding protein 1; DNA-binding protein AGIE-BP1; MIBP-1; Myc intron-binding protein 1", "protein_names_refseq": "DNA-binding protein AGIE-BP1; MIBP-1; angiotensinogen gene-inducible enhancer-binding protein 1; c-myc intron binding protein 1; human immunodeficiency virus type 1 enhancer-binding protein 2; human immunodeficiency virus type I enhancer binding protein 2; human immunodeficiency virus type I enhancer-binding protein 2 homolog; myc intron-binding protein 1", "tax_id": 10116, "disease": "juvenile polyposis syndrome (Disease Ontology:DOID:0050787); autosomal dominant intellectual developmental disorder 43 (Disease Ontology:DOID:0070073); intellectual disability (Disease Ontology:DOID:1059); Alzheimer's disease (Disease Ontology:DOID:10652); asthma (Disease Ontology:DOID:2841); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:29721)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "2017183;22294689;22673903;7838722", "class_list": "", "function": "Binds to DNA at the acute-phase response element of the angiotensinogen gene and related nuclear factor kappa-B binding sites through a zinc-finger motif., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q63725", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q00900-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P37091-1", "uniprot_id": [ { "id": "SCNNG_RAT", "url": "https://www.uniprot.org/uniprot/P37091", "type": "external" } ], "mass": 74066.0, "length": 650, "protein_name": "Epithelial sodium channel subunit gamma", "gene_name": "Scnn1g", "organism": "Rat", "refseq_name": "epithelial sodium channel subunit gamma", "refseq_ac": [ { "id": "NP_058742", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058742", "type": "external" } ], "gene_names_uniprotkb": "Scnn1g; RCNaCh2", "gene_names_refseq": "ENaC; Scnn1g", "protein_names_uniprotkb": "Epithelial sodium channel subunit gamma; Amiloride-sensitive sodium channel subunit gamma; Gamma-ENaC; Gamma-NaCH; Nonvoltage-gated sodium channel 1 subunit gamma; SCNEG; pithelial Na(+) channel subunit gamma", "protein_names_refseq": "SCNEG; Sodium channel, nonvoltage-gated 1, gamma (epithelial); amiloride sensitive sodium channel gamma1 subunit; amiloride-sensitive sodium channel subunit gamma; epithelial Na(+) channel subunit gamma; epithelial sodium channel gamma subunit; epithelial sodium channel subunit gamma; gamma-ENaC; gamma-NaCH; nonvoltage-gated sodium channel 1 subunit gamma; pithelial Na(+) channel subunit gamma; sodium channel epithelial 1 gamma subunit; sodium channel, non-voltage-gated 1, gamma subunit; sodium channel, nonvoltage-gated, type I, gamma", "tax_id": 10116, "disease": "Liddle syndrome (Disease Ontology:DOID:0050477); autosomal recessive pseudohypoaldosteronism type 1 (Disease Ontology:DOID:0060854); bronchiectasis 3 (Disease Ontology:DOID:0080528); neurodegenerative disease (Disease Ontology:DOID:1289); hypokalemic periodic paralysis (Disease Ontology:DOID:14452); ischemia (Disease Ontology:DOID:326); pseudohypoaldosteronism (Disease Ontology:DOID:4479)", "pathway": " (rno:24768); (R-RNO-2672351); (R-RNO-9730628)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "11323714;12424229;12654927;28954214;29767556;30659401;30736831;31522814;8107805;8188647;8665844;9039092;9118951;9351815;9501257", "class_list": "", "function": "Based on the widespread presence of ENaC along the epididymis we suggest that mutations in ENaC subunits may also be associated with male infertility., [RefSeq, PubMed]; Decreased in plasma aldosterone, Na(+) and ENaC levels in kidneys under testosterone influence indicated that testosterone-induced increased in mean arterial pressure (MAP) were not due to increased plasma aldosterone and ENaC levels in kidneys, and thus the testosterone effect on MAP likely involve other mechanisms., [RefSeq, PubMed]; The SCNN1G defects triggered programmed cell death via inhibiting miR-21 and upregulating PTEN, which then orchestrated the key downstream regulators, including Bcl2, Bax2, and cleaved Caspse-3 in a way that favors cell apoptosis., [RefSeq, PubMed]; The presence of active plasmin in urine in hydronephrosis could cause abnormal proteolytic activation of ENaC-gamma and impaired ability to excrete Na via NCC., [RefSeq, PubMed]; These findings reveal ENaC as an interactor and potential regulator of Cav3.2 calcium channels expressed in neuronal tissues. Publication Status: Online-Only, [RefSeq, PubMed]; This is one of the three pore-forming subunits of the heterotrimeric epithelial sodium channel (ENaC), a critical regulator of sodium balance and fluid homeostasis (PubMed:8107805, PubMed:8188647, PubMed:9118951). ENaC operates in epithelial tissues, where it mediates the electrodiffusion of sodium ions from extracellular fluid through the apical membrane of cells, with water following osmotically (PubMed:8107805, PubMed:8188647, PubMed:9118951). It plays a key role in maintaining sodium homeostasis through electrogenic sodium reabsorption in the kidneys. Additionally, ENaC is essential for airway surface liquid homeostasis, which is crucial for proper mucus clearance (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005216 monoatomic ion channel activity;GO:0050699 WW domain binding;GO:0015280 ligand-gated sodium channel activity;GO:0005272 sodium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0070062 extracellular exosome;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0001666 response to hypoxia;GO:0008217 regulation of blood pressure;GO:1904117 cellular response to vasopressin;GO:0006883 intracellular sodium ion homeostasis;GO:0035313 wound healing, spreading of epidermal cells", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P37091-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JLS4-1", "uniprot_id": [ { "id": "SFRP4_RAT", "url": "https://www.uniprot.org/uniprot/Q9JLS4", "type": "external" } ], "mass": 39762.0, "length": 348, "protein_name": "Secreted frizzled-related protein 4", "gene_name": "Sfrp4", "organism": "Rat", "refseq_name": "secreted frizzled-related protein 4 precursor", "refseq_ac": [ { "id": "NP_445996", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445996", "type": "external" } ], "gene_names_uniprotkb": "Sfrp4; Ddc4; Frp", "gene_names_refseq": "Sfrp4", "protein_names_uniprotkb": "Secreted frizzled-related protein 4; DDC-4 protein; sFRP-4", "protein_names_refseq": "DDC-4 protein; FRP; frizzled related protein; sFRP-4; secreted frizzled-related protein 4 precursor", "tax_id": 10116, "disease": "metaphyseal dysplasia (Disease Ontology:DOID:0080019)", "pathway": " (rno:89803)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11485313;12063187;12960062;21120994;23200852;33726573;9409757;9510961", "class_list": "", "function": "Differential expression of secreted frizzled-related protein 4 in decidual cells during pregnancy., [RefSeq, PubMed]; Hydroxytyrosol alters several genes associated with cell proliferation, apoptosis and the Wnt signalling pathway, promoting a high expression of Sfrp4 in rat mammary tumors., [RefSeq, PubMed]; Increased SFRP4 down-regulated the key gene beta-catenin, the downstream effectors gene ccnd1 and fibronectin expression in canonical Wnt pathway at the same time., [RefSeq, PubMed]; MeCP2 attenuates cardiomyocyte hypoxia/reperfusion-induced injury via regulation of the SFRP4/Wnt/beta-catenin axis., [RefSeq, PubMed]; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types (By similarity). SFRP4 plays a role in bone morphogenesis (By similarity). May also act as a regulator of adult uterine morphology and function (PubMed:12063187). May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (PubMed:12960062). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "O35222;Q9JLS5", "ec_number_list": [], "go_molecular_function": "GO:0017147 Wnt-protein binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0009986 cell surface", "go_biological_process": "GO:1902174 positive regulation of keratinocyte apoptotic process;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9JLS4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5EXX3-1", "uniprot_id": [ { "id": "ZBT38_RAT", "url": "https://www.uniprot.org/uniprot/Q5EXX3", "type": "external" } ], "mass": 135300.0, "length": 1203, "protein_name": "Zinc finger and BTB domain-containing protein 38", "gene_name": "Zbtb38", "organism": "Rat", "refseq_name": "zinc finger and BTB domain-containing protein 38", "refseq_ac": [ { "id": "NP_001012489", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012489", "type": "external" } ], "gene_names_uniprotkb": "Zbtb38", "gene_names_refseq": "RGD1310136; Zbtb38", "protein_names_uniprotkb": "Zinc finger and BTB domain-containing protein 38; Zenon; Zinc finger protein expressed in neurons", "protein_names_refseq": "zenon; zinc finger and BTB domain-containing protein 38; zinc finger protein expressed in neurons; zinc finger transcription factor Kaiso", "tax_id": 10116, "disease": "", "pathway": " (rno:315936)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15713629;16075062", "class_list": "", "function": "Transcriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to E-box elements (5'-CACGTG-3'). Can also bind specifically to a single methyl-CpG pair. Represses transcription in a methyl-CpG-dependent manner. Plays an important role in regulating DNA-replication and common fragile sites (CFS) stability in a RBBP6- and MCM10-dependent manner; represses expression of MCM10 which plays an important role in DNA-replication (By similarity). Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons (PubMed:15713629)., [UniProtKB, UniProtKB, PubMed]; ZENON is involved in the maintenance of panneuronal features and/or in the survival of mature neurons., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005694 chromosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5EXX3-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08562-1", "uniprot_id": [ { "id": "SCN9A_RAT", "url": "https://www.uniprot.org/uniprot/O08562", "type": "external" } ], "mass": 226039.0, "length": 1984, "protein_name": "Sodium channel protein type 9 subunit alpha", "gene_name": "Scn9a", "organism": "Rat", "refseq_name": "sodium channel protein type 9 subunit alpha", "refseq_ac": [ { "id": "NP_579823", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_579823", "type": "external" } ], "gene_names_uniprotkb": "Scn9a", "gene_names_refseq": "Nav1.7; PN1; Scn2a; Scn9a", "protein_names_uniprotkb": "Sodium channel protein type 9 subunit alpha; PN1; Peripheral sodium channel 1; Sodium channel protein type IX subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.7", "protein_names_refseq": "peripheral sodium channel 1; sodium channel protein type 9 subunit alpha; sodium channel protein type IX subunit alpha; sodium channel, voltage-gated, type 9, alpha polypeptide; sodium channel, voltage-gated, type IX, alpha subunit; voltage-gated sodium channel subunit alpha Nav1.7", "tax_id": 10116, "disease": "generalized epilepsy with febrile seizures plus (Disease Ontology:DOID:0060170); Dravet syndrome (Disease Ontology:DOID:0080422); generalized epilepsy with febrile seizures plus 2 (Disease Ontology:DOID:0111294); paroxysmal extreme pain disorder (Disease Ontology:DOID:0111537); epilepsy (Disease Ontology:DOID:1826); anxiety disorder (Disease Ontology:DOID:2030); erythromelalgia (Disease Ontology:DOID:9240)", "pathway": " (rno:78956)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "15123669;24497506;32407275;33063281;35418262;36773735;38167752;9037087;9169448", "class_list": "", "function": "Correlative increasing expressions of KIF5b and Nav1.7 in DRG neurons of rats under neuropathic pain conditions., [RefSeq, PubMed]; Extracellular signal-regulated kinase phosphorylation enhancement and NaV1.7 sodium channel upregulation in rat dorsal root ganglia neurons contribute to resiniferatoxin-induced neuropathic pain: The efficacy and mechanism of pulsed radiofrequency therapy., [RefSeq, PubMed]; Involvement of the Sodium Channel Nav1.7 in Paclitaxel-induced Peripheral Neuropathy through ERK1/2 Signaling in Rats., [RefSeq, PubMed]; Long noncoding RNA small nucleolar RNA host gene 5 facilitates neuropathic pain in spinal nerve injury by promoting SCN9A expression via CDK9., [RefSeq, PubMed]; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient., [UniProtKB, UniProtKB]; NGF-Induced Nav1.7 Upregulation Contributes to Chronic Post-surgical Pain by Activating SGK1-Dependent Nedd4-2 Phosphorylation., [RefSeq, PubMed]; Pore-forming subunit of Nav1.7, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes (By similarity). Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient (By similarity). The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:15123669). Nav1.7 plays a crucial role in controlling the excitability and action potential propagation from nociceptor neurons, thereby contributing to the sensory perception of pain (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005248 voltage-gated sodium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0043679 axon terminus;GO:0033268 node of Ranvier;GO:0001518 voltage-gated sodium channel complex", "go_biological_process": "GO:0061368 behavioral response to formalin induced pain;GO:0006954 inflammatory response;GO:0019228 neuronal action potential;GO:0019233 sensory perception of pain;GO:0050965 detection of temperature stimulus involved in sensory perception of pain", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O08562-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08625-1", "uniprot_id": [ { "id": "SYT10_RAT", "url": "https://www.uniprot.org/uniprot/O08625", "type": "external" } ], "mass": 59011.0, "length": 523, "protein_name": "Synaptotagmin-10", "gene_name": "Syt10", "organism": "Rat", "refseq_name": "synaptotagmin-10", "refseq_ac": [ { "id": "NP_113854", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113854", "type": "external" } ], "gene_names_uniprotkb": "Syt10", "gene_names_refseq": "Syt10", "protein_names_uniprotkb": "Synaptotagmin-10; Synaptotagmin X; SytX", "protein_names_refseq": "synaptotagmin X; synaptotagmin-10; sytX", "tax_id": 10116, "disease": "", "pathway": " (rno:60567)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11823420;18508778;9122248", "class_list": "", "function": "Ca(2+) sensor specifically required for the Ca(2+)-dependent exocytosis of secretory vesicles containing IGF1 in neurons of the olfactory bulb. Exocytosis of IGF1 is required for sensory perception of smell. Not involved in Ca(2+)-dependent synaptic vesicle exocytosis (By similarity). Acts through Ca(2+) and phospholipid binding to the C2 domain: Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (PubMed:18508778)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q925B8", "ec_number_list": [], "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0030672 synaptic vesicle membrane;GO:0070382 exocytic vesicle;GO:0098793 presynapse", "go_biological_process": "GO:0007268 chemical synaptic transmission;GO:0016192 vesicle-mediated transport;GO:0007608 sensory perception of smell;GO:0045956 positive regulation of calcium ion-dependent exocytosis;GO:0017158 regulation of calcium ion-dependent exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O08625-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08104-1", "uniprot_id": [ { "id": "SCN3A_RAT", "url": "https://www.uniprot.org/uniprot/P08104", "type": "external" } ], "mass": 221387.0, "length": 1951, "protein_name": "Sodium channel protein type 3 subunit alpha", "gene_name": "Scn3a", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Scn3a", "gene_names_refseq": "", "protein_names_uniprotkb": "Sodium channel protein type 3 subunit alpha; Sodium channel protein brain III subunit alpha; Sodium channel protein type III subunit alpha; Voltage-gated sodium channel subtype III; Voltage-gated sodium channel subunit alpha Nav1.3", "protein_names_refseq": "", "tax_id": 10116, "disease": "generalized epilepsy with febrile seizures plus (Disease Ontology:DOID:0060170); developmental and epileptic encephalopathy 62 (Disease Ontology:DOID:0080420); Dravet syndrome (Disease Ontology:DOID:0080422); familial focal epilepsy with variable foci 4 (Disease Ontology:DOID:0081424); generalized epilepsy with febrile seizures plus 2 (Disease Ontology:DOID:0111294); epilepsy (Disease Ontology:DOID:1826); anxiety disorder (Disease Ontology:DOID:2030)", "pathway": " (rno:497770)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "20678086;22673903;2449363;24497506;25784299;28428547", "class_list": "", "function": "Pore-forming subunit of Nav1.3, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:25784299). In some secretory cell types, it also participates in cell excitability through membrane depolarization and regulates cells responsiveness to stimuli triggering secretion. For instance, it controls the release of serotonin/5-hydroxytryptamine by enterochromaffin cells and is required for both glucagon- and glucose-induced insulin secretion in pancreatic endocrine cells (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005248 voltage-gated sodium channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007399 nervous system development;GO:0019228 neuronal action potential;GO:0019233 sensory perception of pain;GO:0086010 membrane depolarization during action potential;GO:0035725 sodium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P08104-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09951-1", "uniprot_id": [ { "id": "SYN1_RAT", "url": "https://www.uniprot.org/uniprot/P09951", "type": "external" } ], "mass": 73988.0, "length": 704, "protein_name": "Synapsin-1", "gene_name": "Syn1", "organism": "Rat", "refseq_name": "synapsin-1 isoform b", "refseq_ac": [ { "id": "NP_001104252", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104252", "type": "external" } ], "gene_names_uniprotkb": "Syn1", "gene_names_refseq": "Syn1", "protein_names_uniprotkb": "Synapsin-1; Synapsin I", "protein_names_refseq": "synapsin-1 isoform b; synapsin-1", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); withdrawal disorder (Disease Ontology:DOID:0060001); autism spectrum disorder (Disease Ontology:DOID:0060041); non-syndromic X-linked intellectual disability 50 (Disease Ontology:DOID:0112029); X-linked epilepsy with variable learning disabilities and behavior disorders (Disease Ontology:DOID:0112122); opioid abuse (Disease Ontology:DOID:11206); major depressive disorder (Disease Ontology:DOID:1470); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); morphine dependence (Disease Ontology:DOID:2560); amphetamine abuse (Disease Ontology:DOID:670); cocaine abuse (Disease Ontology:DOID:809); substance dependence (Disease Ontology:DOID:9973); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:24949); (R-RNO-181429); (R-RNO-212676)", "pathway_count": 3, "publication_count": 25, "publication_id_list": "10386995;10571231;11685225;11867766;12237306;12438562;18587562;18683930;19896987;20399245;20657584;22673903;23490331;23715865;24280219;2506642;29808487;3028773;3118371;31545395;32580014;33632727;38213171;38843836;8622996", "class_list": "", "function": "MicroRNA-153 impairs hippocampal synaptic vesicle trafficking via downregulation of synapsin I in rats following chronic cerebral hypoperfusion., [RefSeq, PubMed]; Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal (PubMed:11685225). Also involved in the regulation of axon outgrowth and synaptogenesis (By similarity). The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxide functions at a presynaptic level (PubMed:11867766)., [UniProtKB, PubMed, PubMed, UniProtKB]; Synapsin 1 Ameliorates Cognitive Impairment and Neuroinflammation in Rats with Alzheimer's Disease: An Experimental and Bioinformatics Study., [RefSeq, PubMed]; The Phosphoprotein Synapsin Ia Regulates the Kinetics of Dense-Core Vesicle Release., [RefSeq, PubMed]; The miR1345p/Foxp2/Syn1 axis was found to contribute to cognitive impairment in a chronic ischemiainduced early VD model, which may enable the development of new therapeutic strategies for the prevention and treatment of VD., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 6, "mined_n_glycosites": 0, "mined_o_glycosites": 6, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 11, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 11, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 11, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 11, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 27, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 17, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "Q9WUX7", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0048306 calcium-dependent protein binding", "go_cellular_component": "GO:0098850 extrinsic component of synaptic vesicle membrane;GO:0005794 Golgi apparatus;GO:0005856 cytoskeleton;GO:0014069 postsynaptic density;GO:0030424 axon", "go_biological_process": "GO:0097091 synaptic vesicle clustering;GO:0099504 synaptic vesicle cycle;GO:0050808 synapse organization;GO:0007269 neurotransmitter secretion;GO:0048666 neuron development", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "P09951-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100010001001.111.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15242-1", "uniprot_id": [ { "id": "TEST2_RAT", "url": "https://www.uniprot.org/uniprot/P15242", "type": "external" } ], "mass": 38033.0, "length": 333, "protein_name": "Testin-2", "gene_name": "Testin", "organism": "Rat", "refseq_name": "testin-2 precursor", "refseq_ac": [ { "id": "NP_775155", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775155", "type": "external" } ], "gene_names_uniprotkb": "Testin", "gene_names_refseq": "Testin", "protein_names_uniprotkb": "Testin-2; CMB-22; CMB-23", "protein_names_refseq": "CMB-23; testin-2 precursor; testin-2", "tax_id": 10116, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (rno:286916)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "2592382;29393594;31975378;7711203;8447824", "class_list": "", "function": "Testin regulates the blood-testis barrier via disturbing occludin/ZO-1 association and actin organization., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "P15243", "ec_number_list": [], "go_molecular_function": "GO:0004197 cysteine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0030054 cell junction;GO:0005764 lysosome", "go_biological_process": "GO:0051603 proteolysis involved in protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P15242-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27775-1", "uniprot_id": [ { "id": "IPKB_RAT", "url": "https://www.uniprot.org/uniprot/P27775", "type": "external" } ], "mass": 7585.0, "length": 71, "protein_name": "cAMP-dependent protein kinase inhibitor beta", "gene_name": "Pkib", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pkib", "gene_names_refseq": "", "protein_names_uniprotkb": "cAMP-dependent protein kinase inhibitor beta; PKI-beta; cAMP-dependent protein kinase inhibitor, testis isoform", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:24678)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "2052616;22673903", "class_list": "", "function": "Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004862 cAMP-dependent protein kinase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:2000480 negative regulation of cAMP-dependent protein kinase activity;GO:0032206 positive regulation of telomere maintenance", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P27775-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P45380-1", "uniprot_id": [ { "id": "S26A1_RAT", "url": "https://www.uniprot.org/uniprot/P45380", "type": "external" } ], "mass": 75447.0, "length": 703, "protein_name": "Sulfate anion transporter 1", "gene_name": "Slc26a1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Slc26a1; Sat1", "gene_names_refseq": "", "protein_names_uniprotkb": "Sulfate anion transporter 1; Canalicular sulfate transporter; SAT-1; Solute carrier family 26 member 1; Sulfate/carbonate antiporter", "protein_names_refseq": "", "tax_id": 10116, "disease": "calcium oxalate nephrolithiasis (Disease Ontology:DOID:0080652)", "pathway": " (R-RNO-174362); (R-RNO-427601)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "16357056;19369292;21093948;22673903;27210743;3661708;8300633;9689008", "class_list": "", "function": "Sodium-independent sulfate anion transporter (PubMed:16357056, PubMed:19369292, PubMed:21093948, PubMed:3661708, PubMed:8300633, PubMed:9689008). Can transport other anions including thiosulfate, bicarbonate and oxalate by mediating sulfate-oxalate, sulfate-bicarbonate, sulfate-thiosulfate and oxalate-bicarbonate anion exchange (PubMed:16357056, PubMed:19369292, PubMed:21093948, PubMed:3661708, PubMed:8300633, PubMed:9689008)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 3, "mined_n_glycosites": 3, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005452 solute:inorganic anion antiporter activity;GO:0015108 chloride transmembrane transporter activity;GO:0019531 oxalate transmembrane transporter activity;GO:0015116 sulfate transmembrane transporter activity;GO:0140900 chloride:bicarbonate antiporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0019532 oxalate transport;GO:0006821 chloride transport;GO:1902476 chloride transmembrane transport;GO:1902358 sulfate transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P45380-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1000100000001.110.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47861-1", "uniprot_id": [ { "id": "SYT5_RAT", "url": "https://www.uniprot.org/uniprot/P47861", "type": "external" } ], "mass": 43127.0, "length": 386, "protein_name": "Synaptotagmin-5", "gene_name": "Syt5", "organism": "Rat", "refseq_name": "synaptotagmin-5", "refseq_ac": [ { "id": "NP_062223", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062223", "type": "external" } ], "gene_names_uniprotkb": "Syt5", "gene_names_refseq": "Syt5; SytIX", "protein_names_uniprotkb": "Synaptotagmin-5; Synaptotagmin IX; Synaptotagmin V; SytV", "protein_names_refseq": "synaptotagmin IX; synaptotagmin V; synaptotagmin-5; sytV", "tax_id": 10116, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); Bamforth-Lazarus syndrome (Disease Ontology:DOID:0050655); congenital myasthenic syndrome 7 (Disease Ontology:DOID:0110659); congenital myasthenic syndrome (Disease Ontology:DOID:3635); papillary thyroid carcinoma (Disease Ontology:DOID:3969); neuromuscular junction disease (Disease Ontology:DOID:439)", "pathway": " (rno:54309)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12966166;15784685;17264148;38843836;7597049;7698322", "class_list": "", "function": "May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca(2+)-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface., [UniProtKB, PubMed]; Syt1 and Syt5 function redundantly in regulated exocytosis but not endocytosis in PC12 cells., [RefSeq, PubMed]; We show that targeting of Syt IX to the ERC involves constitutive trafficking to the plasma membrane followed by internalization and transport to the ERC., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q56A28", "ec_number_list": [], "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0046982 protein heterodimerization activity;GO:0005509 calcium ion binding;GO:0019905 syntaxin binding;GO:0005544 calcium-dependent phospholipid binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0043025 neuronal cell body;GO:0048471 perinuclear region of cytoplasm;GO:0055038 recycling endosome membrane", "go_biological_process": "GO:0016192 vesicle-mediated transport;GO:0017156 calcium-ion regulated exocytosis;GO:0017158 regulation of calcium ion-dependent exocytosis;GO:2000300 regulation of synaptic vesicle exocytosis;GO:0099502 calcium-dependent activation of synaptic vesicle fusion", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P47861-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54900-1", "uniprot_id": [ { "id": "SCN2B_RAT", "url": "https://www.uniprot.org/uniprot/P54900", "type": "external" } ], "mass": 24145.0, "length": 215, "protein_name": "Sodium channel regulatory subunit beta-2", "gene_name": "Scn2b", "organism": "Rat", "refseq_name": "sodium channel regulatory subunit beta-2 precursor", "refseq_ac": [ { "id": "NP_037009", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037009", "type": "external" } ], "gene_names_uniprotkb": "Scn2b", "gene_names_refseq": "SCNB2; Scn2b", "protein_names_uniprotkb": "Sodium channel regulatory subunit beta-2", "protein_names_refseq": "Sodium channel beta 2; sodium channel regulatory subunit beta-2 precursor; sodium channel regulatory subunit beta-2; sodium channel subunit beta-2; sodium channel, voltage-gated, type II, beta polypeptide; sodium channel, voltage-gated, type II, beta subunit", "tax_id": 10116, "disease": "familial atrial fibrillation (Disease Ontology:DOID:0050650); otitis media (Disease Ontology:DOID:10754)", "pathway": " (rno:25349)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "15178439;22673903;22992729;26259688;26852328;26894959;28871036;8521473;9861042", "class_list": "", "function": "Distribution of SCN2B-containing neurons in the trigeminal ganglion, [RefSeq, PubMed]; MiR-9 suppressed the trafficking of Nav1.1/Nav1.2 from cytoplasm to cell membrane. miR-9 overexpression inhibited Navbeta2 expression by targeting its coding sequence domain. Publication Status: Online-Only, [RefSeq, PubMed]; Navbeta2 is a critical regulator of axonal excitability and synaptic function., [RefSeq, PubMed]; Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:15178439, PubMed:22992729, PubMed:26894959). The accessory beta subunits participate in localization and functional modulation of the Nav channels (PubMed:15178439, PubMed:22992729, PubMed:26894959). Modulates the activity of SCN1A/Nav1.1, SCN2A/Nav1.2, SCN2A/Nav1.3, SCN5A/Nav1.5, SCN8A/Nav1.6, SCN9A/Nav1.7 and SCN10A/Nav1.8 (By similarity) (PubMed:15178439, PubMed:22992729, PubMed:26894959)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization;GO:0017080 sodium channel regulator activity;GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential;GO:0005248 voltage-gated sodium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030315 T-tubule;GO:0033268 node of Ranvier;GO:0043194 axon initial segment;GO:0001518 voltage-gated sodium channel complex", "go_biological_process": "GO:0007399 nervous system development;GO:0086010 membrane depolarization during action potential;GO:0086091 regulation of heart rate by cardiac conduction;GO:0060048 cardiac muscle contraction;GO:0061337 cardiac conduction", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P54900-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2MHH0-1", "uniprot_id": [ { "id": "TARG1_RAT", "url": "https://www.uniprot.org/uniprot/Q2MHH0", "type": "external" } ], "mass": 18722.0, "length": 173, "protein_name": "Trafficking regulator of GLUT4 1", "gene_name": "Trarg1", "organism": "Rat", "refseq_name": "trafficking regulator of GLUT4 1", "refseq_ac": [ { "id": "NP_001034252", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034252", "type": "external" } ], "gene_names_uniprotkb": "Trarg1; Tusc5", "gene_names_refseq": "DSPB1; Trarg1; Tusc5", "protein_names_uniprotkb": "Trafficking regulator of GLUT4 1; BEC-1; Brain endothelial cell-derived protein 1; DSPB1; Dispanin subfamily B member 1; Tumor suppressor candidate 5 homolog", "protein_names_refseq": "BEC-1; brain endothelial cell-derived protein 1; dispanin subfamily B member 1; trafficking regulator of GLUT4 1; tumor suppressor candidate 5 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:360576)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17007998;17592729;22363774;22673903;26240143", "class_list": "", "function": "Detected as a gene dominantly expressed in rat brain endothelial cells; abundantly expressed in adipose tissues, [RefSeq, PubMed]; Findings functionally link TUSC5 to GLUT4 trafficking, insulin action, insulin resistance, and PPARgamma action in the adipocyte, [RefSeq, PubMed]; Regulates insulin-mediated adipose tissue glucose uptake and transport by modulation of SLC2A4 recycling. Not required for SLC2A4 membrane fusion upon an initial stimulus, but rather is necessary for proper protein recycling during prolonged insulin stimulation., [UniProtKB, PubMed, PubMed]; These data suggested that TUSC5 is involved in the differentiation, and its expression is regulated independently of the beta-adrenergic pathway in BAT., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0012505 endomembrane system;GO:0030659 cytoplasmic vesicle membrane;GO:0016020 membrane", "go_biological_process": "GO:0032869 cellular response to insulin stimulus;GO:0072659 protein localization to plasma membrane;GO:0044381 glucose import in response to insulin stimulus;GO:0099638 endosome to plasma membrane protein transport;GO:0099500 vesicle fusion to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q2MHH0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q498M5-1", "uniprot_id": [ { "id": "SH3R2_RAT", "url": "https://www.uniprot.org/uniprot/Q498M5", "type": "external" } ], "mass": 79880.0, "length": 735, "protein_name": "E3 ubiquitin-protein ligase SH3RF2", "gene_name": "Sh3rf2", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase SH3RF2", "refseq_ac": [ { "id": "NP_001029359", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029359", "type": "external" } ], "gene_names_uniprotkb": "Sh3rf2; Posh3; Posher; Ppp1r39; Rnf158", "gene_names_refseq": "Posh2; Ppp1r39; Sh3rf2", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase SH3RF2; 2.3.2.27; POSH-eliminating RING protein; Protein phosphatase 1 regulatory subunit 39; RING finger protein 158; RING-type E3 ubiquitin transferase SH3RF2; SH3 domain-containing RING finger protein 2", "protein_names_refseq": "E3 ubiquitin-protein ligase SH3RF2; POSH-eliminating RING protein; RING finger protein 158; RING-type E3 ubiquitin transferase SH3RF2; SH3 domain-containing RING finger protein 2; protein phosphatase 1 regulatory subunit 39; putative E3 ubiquitin-protein ligase SH3RF2", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (rno:307472)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17762203;22128169;22673903", "class_list": "", "function": "A model in which Sh3rf2 promotes proteasomal degradation of pro-apoptotic POSH in healthy cells and in which apoptotic stimuli lead to rapid loss of Sh3rf2 expression, and consequently to stabilization of POSH and JNK activation and cell death, [RefSeq, PubMed]; Has E3 ubiquitin-protein ligase activity. Acts as an anti-apoptotic regulator of the JNK pathway by ubiquitinating and promoting the degradation of SH3RF1, a scaffold protein that is required for pro-apoptotic JNK activation (PubMed:22128169). Facilitates TNF-mediated recruitment of adapter proteins TRADD and RIPK1 to TNFRSF1A and regulates PAK4 protein stability via inhibition of its ubiquitin-mediated proteasomal degradation. Inhibits PPP1CA phosphatase activity (By similarity)., [UniProtKB, PubMed, UniProtKB]; These results indicate that POSH2 may regulate JNK activation and consequent apoptosis under conditions of increased expression., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0008157 protein phosphatase 1 binding;GO:0004864 protein phosphatase inhibitor activity;GO:0019902 phosphatase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0043066 negative regulation of apoptotic process;GO:0046330 positive regulation of JNK cascade;GO:0031397 negative regulation of protein ubiquitination;GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q498M5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIN1-1", "uniprot_id": [ { "id": "MDM4_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIN1", "type": "external" } ], "mass": 55221.0, "length": 490, "protein_name": "Protein Mdm4", "gene_name": "Mdm4", "organism": "Rat", "refseq_name": "protein Mdm4", "refseq_ac": [ { "id": "NP_001012026", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012026", "type": "external" } ], "gene_names_uniprotkb": "Mdm4; Mdmx", "gene_names_refseq": "Mdm4", "protein_names_uniprotkb": "Protein Mdm4; Double minute 4 protein; Mdm2-like p53-binding protein; Protein Mdmx; p53-binding protein Mdm4", "protein_names_refseq": "MDM4, p53 regulator; Mdm4 p53 binding protein homolog; double minute 4 homolog; double minute 4 protein; mdm2-like p53-binding protein; p53-binding protein Mdm4; protein Mdm4; protein Mdmx; transformed mouse 3T3 cell double minute 4", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (rno:304798); (R-RNO-2559580); (R-RNO-2559585); (R-RNO-5689880); (R-RNO-6804756); (R-RNO-6804757); (R-RNO-6804760); (R-RNO-69541)", "pathway_count": 8, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Contributes to p53/TP53 regulation. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding their transcriptional activation domains. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008047 enzyme activator activity;GO:0008270 zinc ion binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0017053 transcription repressor complex;GO:0005634 nucleus", "go_biological_process": "GO:0003170 heart valve development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation;GO:0045892 negative regulation of DNA-templated transcription;GO:0071456 cellular response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XIN1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62634-1", "uniprot_id": [ { "id": "VGLU1_RAT", "url": "https://www.uniprot.org/uniprot/Q62634", "type": "external" } ], "mass": 61665.0, "length": 560, "protein_name": "Vesicular glutamate transporter 1", "gene_name": "Slc17a7", "organism": "Rat", "refseq_name": "vesicular glutamate transporter 1", "refseq_ac": [ { "id": "NP_446311", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446311", "type": "external" } ], "gene_names_uniprotkb": "Slc17a7; Bnpi; Vglut1", "gene_names_refseq": "BNPI; Slc17a7; Vglut1", "protein_names_uniprotkb": "Vesicular glutamate transporter 1; Brain-specific Na(+)-dependent inorganic phosphate cotransporter; Solute carrier family 17 member 7; VGluT1", "protein_names_refseq": "brain-specific Na(+)-dependent inorganic phosphate cotransporter; brain-specific Na-dependent inorganic phosphate cotransporter; solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7; solute carrier family 17 (vesicular glutamate transporter), member 7; vesicular glutamate transporter 1", "tax_id": 10116, "disease": "sciatic neuropathy (Disease Ontology:DOID:11446); neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330); transient cerebral ischemia (Disease Ontology:DOID:224)", "pathway": " (rno:116638); (R-RNO-210500); (R-RNO-442660)", "pathway_count": 3, "publication_count": 21, "publication_id_list": "10938000;11001057;11502256;11698619;11698620;15028755;16987242;17110340;18080752;18278042;19169251;22673903;25433636;27133463;29642010;29650024;30500398;32562720;33440152;34321562;8202535", "class_list": "", "function": "Coexpression of VGLUT1 and VGLUT2 in precerebellar neurons in the lateral reticular nucleus of the rat., [RefSeq, PubMed]; DNA methylation of Vesicular Glutamate Transporters in the mesocorticolimbic brain following early-life stress and adult ethanol exposure-an explorative study. Publication Status: Online-Only, [RefSeq, PubMed]; Data indicate that VGLUTs play a functional role in exocytotic glutamate release from astrocytes, [RefSeq, PubMed]; Dual retrograde tract tracing was used in combination with fluorescence in situ hybridization (FISH) for VGLUT1 or VGLUT2 mRNA to identify the existence of VGLUT1 or VGLUT2 mRNA neurons that send collateral projections to both the thalamus and the parabrachial nucleus. Publication Status: Online-Only, [RefSeq, PubMed]; Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, proton, potassium, sodium and phosphate (PubMed:10938000, PubMed:11001057, PubMed:11698619, PubMed:18080752, PubMed:19169251, PubMed:25433636, PubMed:27133463, PubMed:29642010, PubMed:33440152, PubMed:8202535). At the synaptic vesicle membrane, mainly functions as an uniporter which transports preferentially L-glutamate but also phosphate from the cytoplasm into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells (PubMed:10938000, PubMed:11001057, PubMed:11698619, PubMed:18080752, PubMed:29642010). The L-glutamate or phosphate uniporter activity is electrogenic and is driven by the proton electrochemical gradient, mainly by the electrical gradient established by the vacuolar H(+)-ATPase across the synaptic vesicle membrane (PubMed:29642010). In addition, functions as a chloride channel that allows a chloride permeation through the synaptic vesicle membrane that affects the proton electrochemical gradient and promotes synaptic vesicles acidification (PubMed:10938000, PubMed:19169251, PubMed:25433636, PubMed:27133463, PubMed:29642010). Moreover, may function as a K(+)/H(+) antiport allowing to maintain the electrical gradient and to decrease chemical gradient and therefore sustain vesicular glutamate uptake (PubMed:25433636). The vesicular K(+)/H(+) antiport activity is electroneutral (PubMed:25433636). At the plasma membrane, following exocytosis, functions as a symporter of Na(+) and phosphate from the extracellular space to the cytoplasm allowing synaptic phosphate homeostasis regulation (PubMed:29642010, PubMed:33440152, PubMed:8202535). The symporter activity is driven by an inside negative membrane potential and is electrogenic (PubMed:29642010). Is necessary for synaptic signaling of visual-evoked responses from photoreceptors (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Study indicates that chronic prolactin administration before kainic acid induced damage induces hippocampal neuroprotection associated with prolactin receptor and VGLUT1 overexpression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A9LRT0", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0005326 neurotransmitter transmembrane transporter activity;GO:0015386 potassium:proton antiporter activity;GO:0005254 chloride channel activity;GO:0008068 extracellularly glutamate-gated chloride channel activity;GO:0005313 L-glutamate transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0045202 synapse;GO:0048786 presynaptic active zone;GO:0098794 postsynapse", "go_biological_process": "GO:0003407 neural retina development;GO:0050803 regulation of synapse structure or activity;GO:0060079 excitatory postsynaptic potential;GO:0007268 chemical synaptic transmission;GO:0035249 synaptic transmission, glutamatergic", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q62634-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TNK0-1", "uniprot_id": [ { "id": "SERC1_RAT", "url": "https://www.uniprot.org/uniprot/Q7TNK0", "type": "external" } ], "mass": 50553.0, "length": 453, "protein_name": "Serine incorporator 1", "gene_name": "Serinc1", "organism": "Rat", "refseq_name": "serine incorporator 1", "refseq_ac": [ { "id": "NP_891996", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_891996", "type": "external" } ], "gene_names_uniprotkb": "Serinc1; Tde1l; Tde2", "gene_names_refseq": "LRRGT00191; Serinc1; Tde1l; Tde2", "protein_names_uniprotkb": "Serine incorporator 1; Tumor differentially expressed protein 1-like; Tumor differentially expressed protein 2", "protein_names_refseq": "serine incorporator 1; tumor differentially expressed 1, like; tumor differentially expressed protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:294421); (R-RNO-977347)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "16120614;22673903", "class_list": "", "function": "Enhances the incorporation of serine into phosphatidylserine and sphingolipids., [UniProtKB, PubMed]; Serinc proteins incorporate serine into membrane lipid synthesis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0030674 protein-macromolecule adaptor activity;GO:0010698 acetyltransferase activator activity;GO:0003964 RNA-directed DNA polymerase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006665 sphingolipid metabolic process;GO:0008654 phospholipid biosynthetic process;GO:0044091 membrane biogenesis;GO:0006658 phosphatidylserine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7TNK0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TSF2-1", "uniprot_id": [ { "id": "VGLU3_RAT", "url": "https://www.uniprot.org/uniprot/Q7TSF2", "type": "external" } ], "mass": 64755.0, "length": 588, "protein_name": "Vesicular glutamate transporter 3", "gene_name": "Slc17a8", "organism": "Rat", "refseq_name": "vesicular glutamate transporter 3", "refseq_ac": [ { "id": "NP_714947", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_714947", "type": "external" } ], "gene_names_uniprotkb": "Slc17a8; Vglut3", "gene_names_refseq": "Slc17a8; Vglut3", "protein_names_uniprotkb": "Vesicular glutamate transporter 3; Solute carrier family 17 member 8; VGluT3", "protein_names_refseq": "solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8; solute carrier family 17 (vesicular glutamate transporter), member 8; vesicular glutamate transporter 3", "tax_id": 10116, "disease": "Parkinsonism (Disease Ontology:DOID:0080855); autosomal dominant nonsyndromic deafness 25 (Disease Ontology:DOID:0110555); sciatic neuropathy (Disease Ontology:DOID:11446); neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330); transient cerebral ischemia (Disease Ontology:DOID:224); cochlear disease (Disease Ontology:DOID:5463); trichinosis (Disease Ontology:DOID:9784)", "pathway": " (rno:266767); (R-RNO-442660)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "12097496;12384506;12388773;14648683;14681932;14751290;15746915;17110340;18215623;18278042;25780293;27133463;29375045;34321562", "class_list": "", "function": "Chronic voluntary wheel running results in increased gene expression of VGLUT3 (and GLT-1) in the frontal cortex without changes in other glutamate transporter subtypes., [RefSeq, PubMed]; DNA methylation of Vesicular Glutamate Transporters in the mesocorticolimbic brain following early-life stress and adult ethanol exposure-an explorative study. Publication Status: Online-Only, [RefSeq, PubMed]; Dendritic expression of VGLUT3 by particular neurons also indicates the potential for retrograde synaptic signaling, [RefSeq, PubMed]; In the rat retina, the dendrites of vGluT3 amacrine cells form a dendritic tree that is bistratified in the inner plexiform layer. The vGluT3 cells have a dendritic overlap and form a regular mosaic, suggesting a single type of amacrine cell., [RefSeq, PubMed]; Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, sodium and phosphate (PubMed:12097496, PubMed:12388773, PubMed:27133463). At the synaptic vesicle membrane, mainly functions as an uniporter that mediates the uptake of L-glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells (PubMed:12097496, PubMed:12388773, PubMed:27133463). The L-glutamate uniporter activity is electrogenic and is driven by the proton electrochemical gradient, mainly by the electrical gradient established by the vacuolar H(+)-ATPase across the synaptic vesicle membrane (PubMed:12097496, PubMed:12388773). In addition, functions as a chloride channel that allows a chloride permeation through the synaptic vesicle membrane that affects the proton electrochemical gradient and promotes synaptic vesicles acidification (PubMed:27133463). At the plasma membrane, following exocytosis, functions as a symporter of Na(+) and phosphate from the extracellular space to the cytoplasm allowing synaptic phosphate homeostasis regulation (By similarity). The symporter activity is electrogenic (By similarity). Moreover, operates synergistically with SLC18A3/VACHT under a constant H(+) gradient, thereby allowing striatal vesicular acetylcholine uptake (PubMed:18278042)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; VGLUT3 is involved in the pathogenesis of visceral hyperalgesia in a rat model of irritable bowel syndrome., [RefSeq, PubMed]; Weak expression of VGLUT3 mRNA is only detected in deep laminae of lumbar spinal cord., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8K1Q1", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0005326 neurotransmitter transmembrane transporter activity;GO:0005254 chloride channel activity;GO:0005313 L-glutamate transmembrane transporter activity;GO:0005436 sodium:phosphate symporter activity;GO:0140788 L-glutamate uniporter activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0043204 perikaryon", "go_biological_process": "GO:0003407 neural retina development;GO:0050803 regulation of synapse structure or activity;GO:0035249 synaptic transmission, glutamatergic;GO:0007605 sensory perception of sound;GO:0055062 phosphate ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q7TSF2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQS5-1", "uniprot_id": [ { "id": "SC5D_RAT", "url": "https://www.uniprot.org/uniprot/Q9EQS5", "type": "external" } ], "mass": 35147.0, "length": 299, "protein_name": "Lathosterol oxidase", "gene_name": "Sc5d", "organism": "Rat", "refseq_name": "lathosterol oxidase", "refseq_ac": [ { "id": "NP_446094", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446094", "type": "external" } ], "gene_names_uniprotkb": "Sc5d; C5d", "gene_names_refseq": "Sc5dl; Sc5d", "protein_names_uniprotkb": "Lathosterol oxidase; 1.14.19.20; C-5 sterol desaturase; Delta(7)-sterol 5-desaturase; Delta(7)-sterol C5(6)-desaturase; Lathosterol 5-desaturase; Sterol-C5-desaturase", "protein_names_refseq": "C-5 sterol desaturase; delta(7)-sterol 5-desaturase; delta(7)-sterol C5(6)-desaturase; lathosterol 5-desaturase; lathosterol oxidase; sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like; sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog; sterol-C5-desaturase (fungal ERG3, delta-5-desaturase)-like", "tax_id": 10116, "disease": "", "pathway": " (rno:114100); (R-RNO-6807047)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "12606372;29735017;4019441;9056262", "class_list": "", "function": "Catalyzes the penultimate step of the biosynthesis of cholesterol, the dehydrogenation of lathosterol into 7-dehydrocholesterol (7-DHC). Cholesterol is the major sterol component in mammalian membranes and a precursor for bile acid and steroid hormone synthesis (PubMed:4019441). In addition to its essential role in cholesterol biosynthesis, it also indirectly regulates ferroptosis through the production of 7-DHC. By diverting the spread of damage caused by peroxyl radicals from the phospholipid components to its sterol nucleus, 7-DHC prevents this form of cell death (By similarity)., [UniProtKB, PubMed, UniProtKB]; Testicular distribution of Delta5- and Delta6-desaturase and stearoyl-CoA desaturase 1 and 2 shows that all four desaturases seem to be localized in the Sertoli cells, with far lower expression in germ cells, [RefSeq, PubMed]; The effect of dietary plant extracts and vegetable oils on hepatic SREBP-1c, Delta5 and Delta6 desaturases has been reported., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.19.20", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.20", "type": "external" } ], "go_molecular_function": "GO:0000248 C-5 sterol desaturase activity;GO:0005506 iron ion binding;GO:0050046 delta7-sterol 5(6)-desaturase activity;GO:0070704 sterol desaturase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0006695 cholesterol biosynthetic process;GO:0033489 cholesterol biosynthetic process via desmosterol;GO:0033490 cholesterol biosynthetic process via lathosterol;GO:0110076 negative regulation of ferroptosis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9EQS5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WVR6-1", "uniprot_id": [ { "id": "LAT2_RAT", "url": "https://www.uniprot.org/uniprot/Q9WVR6", "type": "external" } ], "mass": 58190.0, "length": 533, "protein_name": "Large neutral amino acids transporter small subunit 2", "gene_name": "Slc7a8", "organism": "Rat", "refseq_name": "large neutral amino acids transporter small subunit 2", "refseq_ac": [ { "id": "NP_445894", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445894", "type": "external" } ], "gene_names_uniprotkb": "Slc7a8; Lat2; Lat4", "gene_names_refseq": "Lat2; Lat4; Slc7a8", "protein_names_uniprotkb": "Large neutral amino acids transporter small subunit 2; L-type amino acid transporter 2; Solute carrier family 7 member 8", "protein_names_refseq": "L-type amino acid transporter 2; cationic amino acid transporter y+ system; large neutral amino acids transporter small subunit 2; solute carrier family 7 (amino acid transporter light chain, L system), member 8; solute carrier family 7 (cationic amino acid transporter, y+ system), member 8", "tax_id": 10116, "disease": "sensorineural hearing loss (Disease Ontology:DOID:10003)", "pathway": " (rno:84551); (R-RNO-210991); (R-RNO-352230)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10391916;12975385;15200428;15980244;16027961;17091765;21115085;22185814;22673903;28560461", "class_list": "", "function": "Associates with SLC3A2 to form a functional heterodimeric complex that translocates small and large neutral amino acids with broad specificity and a stoichiometry of 1:1 (PubMed:10391916). Functions as amino acid antiporter mediating the influx of extracellular essential amino acids mainly in exchange with the efflux of highly concentrated intracellular amino acids. Has relatively symmetrical selectivities but strongly asymmetrical substrate affinities at both the intracellular and extracellular sides of the transporter. This asymmetry allows SLC7A8 to regulate intracellular amino acid pools (mM concentrations) by exchange with external amino acids (uM concentration range), equilibrating the relative concentrations of different amino acids across the plasma membrane instead of mediating their net uptake. May play an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane (By similarity). Imports the thyroid hormone diiodothyronine (T2) and to a smaller extent triiodothyronine (T3) but not rT 3 or thyroxine (T4) (By similarity). Mediates the uptake of L-DOPA (PubMed:15200428). May participate in auditory function (By similarity). Mediates the uptake of leucine, 3-iodo-L-tyrosine (MIT) and 3,5-diiodo-L-tyrosine (DIT) (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed]; Data suggest that glucose deprivation sensitivity (model for ischemia) of LAT1 expression in retinal capillary endothelial cells is transcriptionally regulated, and cis-elements within LAT1 promoter region from -162 bp to -155 bp mediate this regulation., [RefSeq, PubMed]; LAT1 and its subunit 4F2hc are highly expressed in the early stage of new bone formation and may have an important role in providing cells with neutral amino acids, including several essential amino acids, at that stage., [RefSeq, PubMed]; Overexpression of renal LAT2 might contribute to enhanced L-DOPA uptake and precedes the onset of hypertension., [RefSeq, PubMed]; Reduced delivery of Arg due to enhanced y+ LAT2-mediated exchange of extracellular Gln for intracellular Arg may contribute to the decrease of nitric oxide/cyclic GMP pathway activity evoked in the brain by hyperammonemia., [RefSeq, PubMed]; The results of the present study suggested that SLC7A8 may serve a critical role in blood pressure control through regulating LDOPA uptake in renal epithelial cells of the proximal tubule., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015180 L-alanine transmembrane transporter activity;GO:0015187 glycine transmembrane transporter activity;GO:0015179 L-amino acid transmembrane transporter activity;GO:0022857 transmembrane transporter activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0009925 basal plasma membrane;GO:0031528 microvillus membrane", "go_biological_process": "GO:0015816 glycine transport;GO:0015820 L-leucine transport;GO:0035524 proline transmembrane transport;GO:1903801 L-leucine import across plasma membrane;GO:0006865 amino acid transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9WVR6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZML2-1", "uniprot_id": [ { "id": "BRSK2_RAT", "url": "https://www.uniprot.org/uniprot/D3ZML2", "type": "external" } ], "mass": 81455.0, "length": 735, "protein_name": "Serine/threonine-protein kinase BRSK2", "gene_name": "Brsk2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Brsk2; Sada", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine/threonine-protein kinase BRSK2; 2.7.11.1; 2.7.11.26; BR serine/threonine-protein kinase 2; Brain-specific serine/threonine-protein kinase 2; Serine/threonine-protein kinase SAD-A", "protein_names_refseq": "", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); depressive disorder (Disease Ontology:DOID:1596)", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "18794346;22673903", "class_list": "", "function": "Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-523' and 'Ser-573'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-175 can inhibit insulin secretion, BRSK2 phosphorylated at Thr-261 can promote insulin secretion. Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmic reticulum (ER) stress (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9PTC7;Q4A1P4", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0051117 ATPase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005813 centrosome;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0006468 protein phosphorylation;GO:0007409 axonogenesis;GO:0051301 cell division;GO:0000086 G2/M transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZML2-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O09171-1", "uniprot_id": [ { "id": "BHMT1_RAT", "url": "https://www.uniprot.org/uniprot/O09171", "type": "external" } ], "mass": 44976.0, "length": 407, "protein_name": "Betaine--homocysteine S-methyltransferase 1", "gene_name": "Bhmt", "organism": "Rat", "refseq_name": "betaine--homocysteine S-methyltransferase 1", "refseq_ac": [ { "id": "NP_110477", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_110477", "type": "external" } ], "gene_names_uniprotkb": "Bhmt", "gene_names_refseq": "Bhmt", "protein_names_uniprotkb": "Betaine--homocysteine S-methyltransferase 1; 2.1.1.5", "protein_names_refseq": "betaine--homocysteine S-methyltransferase 1; betaine-homocysteine methyltransferase", "tax_id": 10116, "disease": "metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); alcohol-associated liver disease (Disease Ontology:DOID:0070658); cerebral infarction (Disease Ontology:DOID:3526); hepatocellular carcinoma (Disease Ontology:DOID:684); pulmonary embolism (Disease Ontology:DOID:9477)", "pathway": " (rno:81508); (R-RNO-1614635); (R-RNO-6798163)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10417327;12487625;12757931;15099744;22673903;28288879;29924862;8753772", "class_list": "", "function": "Data report the crystal structure of rat liver betaine homocysteine s-methyltransferase at 2.5A resolution., [RefSeq, PubMed]; Gene cloning and expression analysis in liver cirrhosis, [RefSeq, PubMed]; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline., [UniProtKB, PubMed, PubMed]; Results describe the site-directed-mutagenesis of putative active-site residues in rat liver betaine-homocysteine S-methyltransferase., [RefSeq, PubMed]; The array of interactions of betaine homocysteine S-methyltransferase in normal liver of Rattus norvegicus, were examined. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 17, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6AZ06", "ec_number_list": [ { "id": "2.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.5", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0008168 methyltransferase activity;GO:0047150 betaine-homocysteine S-methyltransferase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005829 cytosol;GO:0070062 extracellular exosome;GO:0032991 protein-containing complex", "go_biological_process": "GO:0097305 response to alcohol;GO:0006479 protein methylation;GO:0009086 methionine biosynthetic process;GO:0006577 amino-acid betaine metabolic process;GO:0006579 amino-acid betaine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O09171-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54898-1", "uniprot_id": [ { "id": "CAC1G_RAT", "url": "https://www.uniprot.org/uniprot/O54898", "type": "external" } ], "mass": 250407.0, "length": 2254, "protein_name": "Voltage-dependent T-type calcium channel subunit alpha-1G", "gene_name": "Cacna1g", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cacna1g", "gene_names_refseq": "", "protein_names_uniprotkb": "Voltage-dependent T-type calcium channel subunit alpha-1G; Voltage-gated calcium channel subunit alpha Cav3.1", "protein_names_refseq": "", "tax_id": 10116, "disease": "cerebellar ataxia type 42 (Disease Ontology:DOID:0111742)", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "11073957;22673903;9495342", "class_list": "", "function": "Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the `low-voltage activated (LVA)` group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 10, "predicted_n_glycosites": 8, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q548R1", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0097110 scaffold protein binding;GO:0005245 voltage-gated calcium channel activity;GO:0005248 voltage-gated sodium channel activity;GO:0008332 low voltage-gated calcium channel activity;GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0045202 synapse", "go_biological_process": "GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0042391 regulation of membrane potential;GO:0001508 action potential;GO:0007268 chemical synaptic transmission;GO:0051924 regulation of calcium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O54898-1", "record_type": "protein", "filter_code": "0000000.0000110.010000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PPN4-1", "uniprot_id": [ { "id": "CAH8_RAT", "url": "https://www.uniprot.org/uniprot/Q5PPN4", "type": "external" } ], "mass": 32962.0, "length": 290, "protein_name": "Carbonic anhydrase-related protein", "gene_name": "Ca8", "organism": "Rat", "refseq_name": "carbonic anhydrase-related protein", "refseq_ac": [ { "id": "NP_001009662", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009662", "type": "external" } ], "gene_names_uniprotkb": "Ca8; Car8", "gene_names_refseq": "Ca8; Car8", "protein_names_uniprotkb": "Carbonic anhydrase-related protein; CA-VIII; CARP; Carbonic anhydrase VIII", "protein_names_refseq": "CA-VIII; CARP; carbonic anhydrase VIII; carbonic anhydrase-related protein", "tax_id": 10116, "disease": "cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome (Disease Ontology:DOID:0050997); autosomal recessive spinocerebellar ataxia 34 (Disease Ontology:DOID:0070558)", "pathway": " (rno:297814)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Does not have a carbonic anhydrase catalytic activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004089 carbonate dehydratase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5PPN4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2DD29-1", "uniprot_id": [ { "id": "BRSK1_RAT", "url": "https://www.uniprot.org/uniprot/B2DD29", "type": "external" } ], "mass": 85183.0, "length": 778, "protein_name": "Serine/threonine-protein kinase BRSK1", "gene_name": "Brsk1", "organism": "Rat", "refseq_name": "serine/threonine-protein kinase BRSK1", "refseq_ac": [ { "id": "NP_001120809", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001120809", "type": "external" } ], "gene_names_uniprotkb": "Brsk1; Sadb", "gene_names_refseq": "Brsk1; RGD1563268; Sad-b", "protein_names_uniprotkb": "Serine/threonine-protein kinase BRSK1; 2.7.11.1; 2.7.11.26; BR serine/threonine-protein kinase 1; Brain-specific serine/threonine-protein kinase 1; Serine/threonine-protein kinase SAD-B", "protein_names_refseq": "BR serine/threonine-protein kinase 1; brain-specific serine/threonine-protein kinase 1; serine/threonine-protein kinase BRSK1; serine/threonine-protein kinase SAD-B", "tax_id": 10116, "disease": "depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (rno:499073)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "16630837;18324781;18794346;20026642;22673903;25788287;38843836", "class_list": "", "function": "Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-523' and 'Ser-573'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C (By similarity). In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1., [UniProtKB, PubMed]; The activities of both AMPK and BRSK are polarized in developing hippocampal neurons, with high levels in the distal region of extended axons., [RefSeq, PubMed]; The regulation of Wee1 by SadA and SadB kinases is essential for the differentiation of polarized neurons., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F1M6Y8", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0050321 tau-protein kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0014069 postsynaptic density", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0099504 synaptic vesicle cycle;GO:0006468 protein phosphorylation;GO:0007409 axonogenesis;GO:0008306 associative learning", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "B2DD29-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A055-2", "uniprot_id": [ { "id": "CACB4_RAT", "url": "https://www.uniprot.org/uniprot/D4A055", "type": "external" } ], "mass": 57964.0, "length": 519, "protein_name": "Voltage-dependent L-type calcium channel subunit beta-4", "gene_name": "Cacnb4", "organism": "Rat", "refseq_name": "voltage-dependent L-type calcium channel subunit beta-4 isoform 2", "refseq_ac": [ { "id": "NP_001099203", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099203", "type": "external" } ], "gene_names_uniprotkb": "Cacnb4", "gene_names_refseq": "CAB4; Cacnb4", "protein_names_uniprotkb": "Voltage-dependent L-type calcium channel subunit beta-4; CAB4; Calcium channel voltage-dependent subunit beta 4", "protein_names_refseq": "calcium channel beta 4 subunit; calcium channel voltage-dependent subunit beta 4; calcium channel, voltage-dependent, beta 4 subunit; voltage-dependent L-type calcium channel subunit beta-4 isoform 2; voltage-dependent L-type calcium channel subunit beta-4", "tax_id": 10116, "disease": "episodic ataxia type 5 (Disease Ontology:DOID:0050993); dilated cardiomyopathy (Disease Ontology:DOID:12930); generalized epilepsy (Disease Ontology:DOID:1827); episodic ataxia (Disease Ontology:DOID:963)", "pathway": " (rno:58942); (R-RNO-112308)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "15170217;22673903;28587927;30538175", "class_list": "", "function": "Beta4 subunit of the voltage-gated calcium channel (Cacnb4) regulates the rate of cell proliferation in Chinese Hamster Ovary cells, [RefSeq, PubMed]; Study demonstrated that the beta4 subunit of Cav1.2 channels can act as an antiviral agent; overexpression of beta4 increased the amounts of four key antiviral proteins, namely, DDX58, IRF7, IFITM3, and STAT2, and contrasting results were obtained by silencing beta4. Publication Status: Online-Only, [RefSeq, PubMed]; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0005246 calcium channel regulator activity;GO:0099626 voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels;GO:0005245 voltage-gated calcium channel activity;GO:0008331 high voltage-gated calcium channel activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0016607 nuclear speck;GO:0045202 synapse;GO:0098793 presynapse", "go_biological_process": "GO:0046058 cAMP metabolic process;GO:0007528 neuromuscular junction development;GO:0008285 negative regulation of cell population proliferation;GO:0042391 regulation of membrane potential;GO:0006816 calcium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "D4A055-2", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08839-1", "uniprot_id": [ { "id": "BIN1_RAT", "url": "https://www.uniprot.org/uniprot/O08839", "type": "external" } ], "mass": 64533.0, "length": 588, "protein_name": "Myc box-dependent-interacting protein 1", "gene_name": "Bin1", "organism": "Rat", "refseq_name": "myc box-dependent-interacting protein 1", "refseq_ac": [ { "id": "NP_446411", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446411", "type": "external" } ], "gene_names_uniprotkb": "Bin1; Amph2; Amphl", "gene_names_refseq": "Bin1", "protein_names_uniprotkb": "Myc box-dependent-interacting protein 1; Amphiphysin II; Amphiphysin-like protein; Bridging integrator 1", "protein_names_refseq": "Amph2; amphiphysin IIamph2; amphiphysin II; amphiphysin-like protein; myc box-dependent-interacting protein 1", "tax_id": 10116, "disease": "centronuclear myopathy 2 (Disease Ontology:DOID:0111220); prostate adenocarcinoma (Disease Ontology:DOID:2526); breast carcinoma (Disease Ontology:DOID:3459)", "pathway": " (rno:117028); (R-RNO-8856828)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10380931;10430869;16516836;22673903;27760323;9182667;9280305;9341169;9348539;9736607", "class_list": "", "function": "Is a key player in the control of plasma membrane curvature, and membrane shaping and remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling (By similarity). Is a negative regulator of endocytosis (PubMed:27760323, PubMed:9736607). Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production (By similarity). In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates (PubMed:27760323). May be involved in the regulation of MYC activity and the control cell proliferation (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Lower BIN1 levels promote the propagation of Tau pathology by efficiently increasing aggregate internalization by endocytosis and endosomal trafficking., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0005543 phospholipid binding;GO:0042802 identical protein binding;GO:0051015 actin filament binding;GO:0051087 protein-folding chaperone binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098850 extrinsic component of synaptic vesicle membrane;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005737 cytoplasm", "go_biological_process": "GO:1901380 negative regulation of potassium ion transmembrane transport;GO:1904878 negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0043065 positive regulation of apoptotic process;GO:0043547 positive regulation of GTPase activity", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O08839-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A631-1", "uniprot_id": [ { "id": "BIG1_RAT", "url": "https://www.uniprot.org/uniprot/D4A631", "type": "external" } ], "mass": 207890.0, "length": 1846, "protein_name": "Brefeldin A-inhibited guanine nucleotide-exchange protein 1", "gene_name": "Arfgef1", "organism": "Rat", "refseq_name": "brefeldin A-inhibited guanine nucleotide-exchange protein 1", "refseq_ac": [ { "id": "NP_001263985", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263985", "type": "external" } ], "gene_names_uniprotkb": "Arfgef1", "gene_names_refseq": "Arfgef1; BIG1; RGD1560793", "protein_names_uniprotkb": "Brefeldin A-inhibited guanine nucleotide-exchange protein 1; ADP-ribosylation factor guanine nucleotide-exchange factor 1; BIG1; Brefeldin A-inhibited GEP 1", "protein_names_refseq": "ADP ribosylation factor guanine nucleotide exchange factor 1; ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited); brefeldin A-inhibited GEP 1; brefeldin A-inhibited guanine nucleotide-exchange protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:312915)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11809827;15644318;22673903;23220274;24090963;24198228", "class_list": "", "function": "A role was identified for BIG1 in modulating GABA-gated Cl(-) influx through regulation of GABA A receptor expression., [RefSeq, PubMed]; BIG1, through its ability to activate ADP-ribosylation factor 1, regulates cell-surface levels and function of ABCA1., [RefSeq, PubMed]; Myosin IXb binds to BIG1, which regulates its Rho-GTPase activating protein activity [BIG1], [RefSeq, PubMed]; Overexpression of BIG1 in neurites significantly increases ERK phosphorylation., [RefSeq, PubMed]; Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturation of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competitive RhoA binding. The function in the nucleus remains to be determined (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017022 myosin binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0034237 protein kinase A regulatory subunit binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0015031 protein transport;GO:0031175 neuron projection development;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0009101 glycoprotein biosynthetic process;GO:0090303 positive regulation of wound healing", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "D4A631-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1Y3-1", "uniprot_id": [ { "id": "CADH2_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z1Y3", "type": "external" } ], "mass": 99686.0, "length": 906, "protein_name": "Cadherin-2", "gene_name": "Cdh2", "organism": "Rat", "refseq_name": "cadherin-2 precursor", "refseq_ac": [ { "id": "NP_112623", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112623", "type": "external" } ], "gene_names_uniprotkb": "Cdh2", "gene_names_refseq": "Cdh2; N-cadherin", "protein_names_uniprotkb": "Cadherin-2; N-cadherin; Neural cadherin", "protein_names_refseq": "cadherin 2, type 1, N-cadherin (neuronal); cadherin-2 precursor; neural cadherin", "tax_id": 10116, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); agenesis of corpus callosum, cardiac, ocular, and genital syndrome (Disease Ontology:DOID:0080948); arrhythmogenic right ventricular dysplasia 14 (Disease Ontology:DOID:0080959); prostate cancer (Disease Ontology:DOID:10283); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); cancer (Disease Ontology:DOID:162)", "pathway": " (rno:83501); (R-RNO-381426); (R-RNO-418990); (R-RNO-525793); (R-RNO-8957275)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "10.1039/D0MO00044B;17988630;21617128;24090084;29133434;34106099;37654026;38127465;38169592;38843836;9528971", "class_list": "", "function": "Cadherins are calcium-dependent cell adhesion proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. Plays a role in cell-to-cell junction formation between pancreatic beta cells and neural crest stem (NCS) cells, promoting the formation of processes by NCS cells. Required for proper neurite branching. Required for pre- and postsynaptic organization. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. May promote axon outgrowth and motor fiber repair via DSP-mediated recruitment to outgrowth tips., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Essential role of obscurin kinase-1 in cardiomyocyte coupling via N-cadherin phosphorylation. Publication Status: Online-Only, [RefSeq, PubMed]; N-cadherin Alleviates Apoptosis and Senescence of Nucleus Pulposus Cells via Suppressing ROS-dependent ERS in the Hyper-osmolarity Microenvironment. Publication Status: Online-Only, [RefSeq, PubMed]; Plk2 promotes synaptic destabilization through disruption of N-cadherin adhesion complexes during homeostatic adaptation to hyperexcitation., [RefSeq, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 6, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 3, "reported_phosphosites": 4, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 7, "disease_count": 6, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q9R0T5", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0019899 enzyme binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005912 adherens junction", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0097091 synaptic vesicle clustering;GO:0007155 cell adhesion;GO:0016477 cell migration;GO:0043410 positive regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q9Z1Y3-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31000-1", "uniprot_id": [ { "id": "VIME_RAT", "url": "https://www.uniprot.org/uniprot/P31000", "type": "external" } ], "mass": 53733.0, "length": 466, "protein_name": "Vimentin", "gene_name": "Vim", "organism": "Rat", "refseq_name": "vimentin", "refseq_ac": [ { "id": "NP_112402", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112402", "type": "external" } ], "gene_names_uniprotkb": "Vim", "gene_names_refseq": "Vim", "protein_names_uniprotkb": "Vimentin", "protein_names_refseq": "vimentin", "tax_id": 10116, "disease": "cataract 30 (Disease Ontology:DOID:0110248); Alzheimer's disease (Disease Ontology:DOID:10652); Chagas disease (Disease Ontology:DOID:12140); Sjogren's syndrome (Disease Ontology:DOID:12894); Behcet's disease (Disease Ontology:DOID:13241); atherosclerosis (Disease Ontology:DOID:1936); nephrosis (Disease Ontology:DOID:2527); coronary artery disease (Disease Ontology:DOID:3393); cerebral infarction (Disease Ontology:DOID:3526); pulmonary hypertension (Disease Ontology:DOID:6432); rheumatoid arthritis (Disease Ontology:DOID:7148); varicose veins (Disease Ontology:DOID:799); hyperthyroidism (Disease Ontology:DOID:7998); systemic lupus erythematosus (Disease Ontology:DOID:9074); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (rno:81818); (R-RNO-264870); (R-RNO-390522); (R-RNO-9013422); (R-RNO-9646399)", "pathway_count": 5, "publication_count": 14, "publication_id_list": "12639940;12686602;1540169;15985269;16128803;2192768;22673903;25291543;27726058;31626376;34502162;38467554;38843836;9168797", "class_list": "", "function": "Impairment of Assembly of the Vimentin Intermediate Filaments Leads to Suppression of Formation and Maturation of Focal Contacts and Alteration of the Type of Cellular Protrusions., [RefSeq, PubMed]; Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The role of vimentin in directional migration of rat fibroblasts., [RefSeq, PubMed]; Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front. Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner. May promote axon outgrowth and motor fiber repair via DSP-mediated recruitment to outgrowth tips., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 3, "mined_n_glycosites": 0, "mined_o_glycosites": 3, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 3, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 41, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 15, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990254 keratin filament binding;GO:0060090 molecular adaptor activity;GO:0003723 RNA binding;GO:0005200 structural constituent of cytoskeleton;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005777 peroxisome;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0043403 skeletal muscle tissue regeneration;GO:0050770 regulation of axonogenesis;GO:0060252 positive regulation of glial cell proliferation;GO:0010043 response to zinc ion;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P31000-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100010000001.110.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4QQU1-1", "uniprot_id": [ { "id": "BUD13_RAT", "url": "https://www.uniprot.org/uniprot/Q4QQU1", "type": "external" } ], "mass": 71869.0, "length": 636, "protein_name": "BUD13 homolog", "gene_name": "Bud13", "organism": "Rat", "refseq_name": "BUD13 homolog", "refseq_ac": [ { "id": "NP_001020448", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020448", "type": "external" } ], "gene_names_uniprotkb": "Bud13", "gene_names_refseq": "Bud13; RGD1308076", "protein_names_uniprotkb": "BUD13 homolog", "protein_names_refseq": "BUD13 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:300687); (R-RNO-72163)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 30, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005681 spliceosomal complex;GO:0071006 U2-type catalytic step 1 spliceosome;GO:0005684 U2-type spliceosomal complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4QQU1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08557-1", "uniprot_id": [ { "id": "DDAH1_RAT", "url": "https://www.uniprot.org/uniprot/O08557", "type": "external" } ], "mass": 31426.0, "length": 285, "protein_name": "N(G),N(G)-dimethylarginine dimethylaminohydrolase 1", "gene_name": "Ddah1", "organism": "Rat", "refseq_name": "N(G),N(G)-dimethylarginine dimethylaminohydrolase 1", "refseq_ac": [ { "id": "NP_071633", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071633", "type": "external" } ], "gene_names_uniprotkb": "Ddah1; Ddah", "gene_names_refseq": "Ddah1", "protein_names_uniprotkb": "N(G),N(G)-dimethylarginine dimethylaminohydrolase 1; 3.5.3.18; DDAH-1; DDAHI; Dimethylargininase-1; Dimethylarginine dimethylaminohydrolase 1", "protein_names_refseq": "DDAH-1; DDAHI; N(G),N(G)-dimethylarginine dimethylaminohydrolase 1; NG,NG dimethylarginine dimethylaminohydrolase; dimethylargininase-1", "tax_id": 10116, "disease": "hypertension (Disease Ontology:DOID:10763); cardiovascular system disease (Disease Ontology:DOID:1287); coronary artery disease (Disease Ontology:DOID:3393)", "pathway": " (rno:64157); (R-RNO-203615)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "12237779;14766200;15256062;16632550;22673903;31870966;33574439;35509834;37116560;9003431", "class_list": "", "function": "DDAH-1 via HIF-1 target genes improves cerebral ischemic tolerance after hypoxic preconditioning and middle cerebral artery occlusion-reperfusion., [RefSeq, PubMed]; DDAH-1, via regulation of ADMA levels, protects against ischemia-induced blood-brain barrier leakage. Erratum:[Lab Invest. 2021 Oct;101(10):1411-1413. doi: 10.1038/s41374-021-00588-4. PMID: 34341461], [RefSeq, PubMed]; DDAH1/ADMA Regulates Adiponectin Resistance in Cerebral Ischemia via the ROS/FOXO1/APR1 Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Dimethylarginine dimethylaminohydrolase plays a pivotal role in tumour growth and the development of the tumour vasculature by regulating the concentration of nitric oxide and altering vascular endothelial cell growth factor production., [RefSeq, PubMed]; Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation., [UniProtKB, PubMed]; LncRNA DANCR deficiency promotes high glucose-induced endothelial to mesenchymal transition in cardiac microvascular cells via the FoxO1/DDAH1/ADMA signaling pathway., [RefSeq, PubMed]; The DDAH1 mRNA expression in the embryonic spinal cord, which was especially strong in the ventral horn and dorsal root ganglion (DRG). DDAH1 was also detected in the brain, kidney, digestive tract, and in other tissues., [RefSeq, PubMed]; Transfected into glioma cells in nude mice increases cell hypoxia and points to an inverse relationship of tumor oxygenation and angiogenesis in vivo., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.18", "type": "external" } ], "go_molecular_function": "GO:0016403 dimethylargininase activity;GO:0046872 metal ion binding;GO:0016597 amino acid binding;GO:0030235 nitric-oxide synthase regulator activity", "go_cellular_component": "", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0045429 positive regulation of nitric oxide biosynthetic process;GO:0043116 negative regulation of vascular permeability;GO:0045766 positive regulation of angiogenesis;GO:0003073 regulation of systemic arterial blood pressure", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O08557-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P14668-1", "uniprot_id": [ { "id": "ANXA5_RAT", "url": "https://www.uniprot.org/uniprot/P14668", "type": "external" } ], "mass": 35745.0, "length": 319, "protein_name": "Annexin A5", "gene_name": "Anxa5", "organism": "Rat", "refseq_name": "annexin A5", "refseq_ac": [ { "id": "NP_037264", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037264", "type": "external" } ], "gene_names_uniprotkb": "Anxa5; Anx5", "gene_names_refseq": "Anx5; Anxa5; CPB-I; LC5", "protein_names_uniprotkb": "Annexin A5; Anchorin CII; Annexin V; Annexin-5; CPB-I; Calphobindin I; Endonexin II; Lipocortin V; PAP-I; PP4; Placental anticoagulant protein 4; Placental anticoagulant protein I; Thromboplastin inhibitor; VAC-alpha; Vascular anticoagulant-alpha", "protein_names_refseq": "Annexin V; CBP-I; PAP-I; PP4; VAC-alpha; anchorin CII; annexin A5; annexin-5; calphobindin I; endonexin II; lipocortin V; placental anticoagulant protein 4; placental anticoagulant protein I; thromboplastin inhibitor; vascular anticoagulant-alpha", "tax_id": 10116, "disease": "amyotrophic lateral sclerosis type 23 (Disease Ontology:DOID:0080225); nephrotic syndrome type 2 (Disease Ontology:DOID:0080379); Alzheimer's disease (Disease Ontology:DOID:10652); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); cryptorchidism (Disease Ontology:DOID:11383); Lewy body dementia (Disease Ontology:DOID:12217); Parkinson's disease (Disease Ontology:DOID:14330); hypothyroidism (Disease Ontology:DOID:1459); glomerulonephritis (Disease Ontology:DOID:2921); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); systemic scleroderma (Disease Ontology:DOID:418); autoimmune disease of the nervous system (Disease Ontology:DOID:438); myocardial infarction (Disease Ontology:DOID:5844); hyperthyroidism (Disease Ontology:DOID:7998); Wilson disease (Disease Ontology:DOID:893)", "pathway": " (rno:25673); (R-RNO-114608)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "11342135;21454685;22673903;28543594;29393594;2968983;31515275;33840679;37595881;7556178;7583670;8362244;8667030;9609693", "class_list": "", "function": "Further analysis showed that miR-124-3p enhanced the viability of 6-OHDA-treated PC12 or SH-SY5Y cells by targeting ANXA5, which was associated with the stimulation of the ERK pathway., [RefSeq, PubMed]; Sequential preovulatory expression of a gonadotropin-releasing hormone-inducible gene, Nr4a3, and its suppressor Anxa5 in the pituitary gland of female rats., [RefSeq, PubMed]; The increment of annexin V-positive microvesicles versus annexin V-negative microvesicles in CSF of an animal model of Alzheimer's disease., [RefSeq, PubMed]; These results identify a novel role for ANXA5 specifically in the recognition and binding step of clearance phagocytosis, which is essential to retinal physiology. Publication Status: Online-Only, [RefSeq, PubMed]; This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0017046 peptide hormone binding;GO:0030971 receptor tyrosine kinase binding;GO:0005544 calcium-dependent phospholipid binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0043204 perikaryon", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0051592 response to calcium ion;GO:0007596 blood coagulation;GO:0097066 response to thyroid hormone;GO:0030195 negative regulation of blood coagulation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P14668-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27139-1", "uniprot_id": [ { "id": "CAH2_RAT", "url": "https://www.uniprot.org/uniprot/P27139", "type": "external" } ], "mass": 29114.0, "length": 260, "protein_name": "Carbonic anhydrase 2", "gene_name": "Ca2", "organism": "Rat", "refseq_name": "carbonic anhydrase 2", "refseq_ac": [ { "id": "NP_062164", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062164", "type": "external" } ], "gene_names_uniprotkb": "Ca2", "gene_names_refseq": "Ca2; Car2", "protein_names_uniprotkb": "Carbonic anhydrase 2; 4.2.1.1; 4.2.1.69; CA-II; Carbonate dehydratase II; Carbonic anhydrase II; Cyanamide hydratase CA2", "protein_names_refseq": "CA-II; carbonate dehydratase II; carbonic anhydrase 2; carbonic anhydrase II; cyanamide hydratase CA2", "tax_id": 10116, "disease": "autoimmune pancreatitis (Disease Ontology:DOID:0040091); chronic pancreatitis (Disease Ontology:DOID:0051065); colorectal carcinoma (Disease Ontology:DOID:0080199); autosomal recessive osteopetrosis 3 (Disease Ontology:DOID:0110941); primary biliary cholangitis (Disease Ontology:DOID:12236); Sjogren's syndrome (Disease Ontology:DOID:12894); osteopetrosis (Disease Ontology:DOID:13533); viral hepatitis (Disease Ontology:DOID:1884); Lynch syndrome (Disease Ontology:DOID:3883); bladder urothelial carcinoma (Disease Ontology:DOID:4006); alcoholic pancreatitis (Disease Ontology:DOID:4988); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (rno:54231); (R-RNO-1237044); (R-RNO-1247673); (R-RNO-1475029)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "1765271;22673903;29393594;31694264;34502162;9074494;9665810", "class_list": "", "function": "Catalyzes the reversible hydration of carbon dioxide (By similarity). Can also hydrate cyanamide to urea (By similarity). Involved in the regulation of fluid secretion into the anterior chamber of the eye (By similarity). Essential for bone resorption and osteoclast differentiation (PubMed:9665810). Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption (By similarity). Stimulates the chloride-bicarbonate exchange activity of SLC26A6 (By similarity)., [UniProtKB, PubMed, UniProtKB]; Uncoupling of Carbonic Anhydrase from Na-H exchanger-1 in Experimental Colitis: A Possible Mechanistic Link with Na-H Exchanger. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 14, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.2.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.1", "type": "external" }, { "id": "4.2.1.69", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.69", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004064 arylesterase activity;GO:0004089 carbonate dehydratase activity;GO:0018820 cyanamide hydratase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0045124 regulation of bone resorption;GO:0010043 response to zinc ion;GO:0001822 kidney development;GO:0045780 positive regulation of bone resorption", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P27139-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30543-1", "uniprot_id": [ { "id": "AA2AR_RAT", "url": "https://www.uniprot.org/uniprot/P30543", "type": "external" } ], "mass": 44999.0, "length": 410, "protein_name": "Adenosine receptor A2a", "gene_name": "Adora2a", "organism": "Rat", "refseq_name": "adenosine receptor A2a isoform A2AR", "refseq_ac": [ { "id": "NP_445746", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445746", "type": "external" } ], "gene_names_uniprotkb": "Adora2a", "gene_names_refseq": "A2ar; ADENO; Adora2a; Adora2l1", "protein_names_uniprotkb": "Adenosine receptor A2a", "protein_names_refseq": "Adenosine A2a-receptor; adenosine receptor A2a isoform A2AR; adenosine receptor A2a", "tax_id": 10116, "disease": "myopia (Disease Ontology:DOID:11830); primary pulmonary hypertension (Disease Ontology:DOID:14557); asthma (Disease Ontology:DOID:2841); lung disease (Disease Ontology:DOID:850)", "pathway": " (rno:25369); (R-RNO-417973); (R-RNO-5683826)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "1279342;1599465;16339847;23994616;24293369;34043863;34946538;35907034;39192377", "class_list": "", "function": "A2AR regulate inflammation through PKA/NF-kappaB signaling pathways in intervertebral disc degeneration. Publication Status: Online-Only, [RefSeq, PubMed]; Abeta1-42 peptides blunt the adenosine A2A receptor-mediated control of the interplay between P2X7 and P2Y1 receptors mediated calcium responses in astrocytes. Publication Status: Online-Only, [RefSeq, PubMed]; Attenuation of Tumor Development in Mammary Carcinoma Rats by Theacrine, an Antagonist of Adenosine 2A Receptor. Publication Status: Online-Only, [RefSeq, PubMed]; Rat A2AR gene encodes two distinct proteins (A2AR and uORF5) in an A2AR-dependent manner. Our study reveals a new example of the complexity of the mammalian genome and provides novel insights into the function of A2AR., [RefSeq, PubMed]; Receptor for adenosine (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (PubMed:23994616)., [UniProtKB, UniProtKB, PubMed]; Regulation of hippocampal postnatal and adult neurogenesis by adenosine A2A receptor: Interaction with brain-derived neurotrophic factor., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0001609 G protein-coupled adenosine receptor activity;GO:0031802 type 5 metabotropic glutamate receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon", "go_biological_process": "GO:0043279 response to alkaloid;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007271 synaptic transmission, cholinergic;GO:0007626 locomotory behavior", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P30543-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35426-1", "uniprot_id": [ { "id": "CDK4_RAT", "url": "https://www.uniprot.org/uniprot/P35426", "type": "external" } ], "mass": 33799.0, "length": 303, "protein_name": "Cyclin-dependent kinase 4", "gene_name": "Cdk4", "organism": "Rat", "refseq_name": "cyclin-dependent kinase 4 isoform 1", "refseq_ac": [ { "id": "NP_446045", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446045", "type": "external" } ], "gene_names_uniprotkb": "Cdk4", "gene_names_refseq": "Cdk4", "protein_names_uniprotkb": "Cyclin-dependent kinase 4; 2.7.11.22; Cell division protein kinase 4; PSK-J3", "protein_names_refseq": "PSK-J3; cell division protein kinase 4; cyclin-dependent kinase 4 isoform 1", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283); intellectual disability (Disease Ontology:DOID:1059); cystinosis (Disease Ontology:DOID:1064); urinary bladder cancer (Disease Ontology:DOID:11054); prostatic hypertrophy (Disease Ontology:DOID:11132); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); pancreatic cancer (Disease Ontology:DOID:1793); islet cell tumor (Disease Ontology:DOID:1799); nephroblastoma (Disease Ontology:DOID:2154); transitional cell carcinoma (Disease Ontology:DOID:2671); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); breast carcinoma (Disease Ontology:DOID:3459); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684); familial melanoma (Disease Ontology:DOID:6846); non-functioning pancreatic endocrine tumor (Disease Ontology:DOID:7698); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); type 2 diabetes mellitus (Disease Ontology:DOID:9352); encephalitis (Disease Ontology:DOID:9588); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:94201); (R-RNO-187577); (R-RNO-2559580); (R-RNO-2559582); (R-RNO-2559585); (R-RNO-3214858); (R-RNO-69231); (R-RNO-75815); (R-RNO-8849470); (R-RNO-9616222); (R-RNO-9754119); (R-RNO-9929491)", "pathway_count": 12, "publication_count": 6, "publication_id_list": "22673903;30701428;32666227;33336721;37684532;8466525", "class_list": "", "function": "A small molecule dual inhibitor of the c-MYC activated kinases ARK5 and CDK4/6, is being developed., [RefSeq, PubMed]; CDK4 and CDK5 Inhibition Have Comparable Mild Hypothermia Effects in Preventing Drp1-Dependent Mitochondrial Fission and Neuron Death Induced by MPP()., [RefSeq, PubMed]; Cyclin D1-Cdk4 regulates neuronal activity through phosphorylation of GABAA receptors. Publication Status: Online-Only, [RefSeq, PubMed]; LncRNA SNHG1 attenuates neuropathic pain following spinal cord injury by regulating CDK4 level., [RefSeq, PubMed]; Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 28, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.1.1.320", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.320", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0044877 protein-containing complex binding;GO:0016301 kinase activity;GO:0004693 cyclin-dependent protein serine/threonine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007165 signal transduction;GO:0008284 positive regulation of cell population proliferation;GO:0010971 positive regulation of G2/M transition of mitotic cell cycle;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P35426-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35565-1", "uniprot_id": [ { "id": "CALX_RAT", "url": "https://www.uniprot.org/uniprot/P35565", "type": "external" } ], "mass": 67255.0, "length": 591, "protein_name": "Calnexin", "gene_name": "Canx", "organism": "Rat", "refseq_name": "calnexin precursor", "refseq_ac": [ { "id": "NP_742005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742005", "type": "external" } ], "gene_names_uniprotkb": "Canx", "gene_names_refseq": "Canx", "protein_names_uniprotkb": "Calnexin", "protein_names_refseq": "calnexin precursor", "tax_id": 10116, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:29144); (R-RNO-2132295); (R-RNO-8984722); (R-RNO-901042); (R-RNO-9020956); (R-RNO-9768727); (R-RNO-983170)", "pathway_count": 7, "publication_count": 7, "publication_id_list": "10393181;22673903;27425249;28912545;29522763;8136357;8440713", "class_list": "", "function": "Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse., [UniProtKB, UniProtKB, UniProtKB]; The authors demonstrate that the Genetic Absence Epilepsy Rat from Strasbourg (GAERS) missense mutation located in the Cav3.2 III-IV linker alters the Cav3.2/calnexin interaction, resulting in an increased surface expression of the channel and a concomitant elevation in calcium influx. Publication Status: Online-Only, [RefSeq, PubMed]; The mechanism underlying these effects may involve the direct binding of PPARgamma to the pre-miR-711 promoter for the upregulation of miR-711, which may induce ER stress-mediated cardiomyocyte apoptosis via calnexin., [RefSeq, PubMed]; Therefore, these results indicate that obesity down-regulates CNX and CRT expressions and their activities and diabetes up-regulates the expressions and activities of CNX and CRT. Our findings clearly suggest that metabolic syndrome affects the lectin-like chaperones in the CNX/CRT cycle at both the activity and expression levels., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0034185 apolipoprotein binding;GO:0051082 unfolded protein binding;GO:0005509 calcium ion binding;GO:0030246 carbohydrate binding;GO:0035255 ionotropic glutamate receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005783 endoplasmic reticulum;GO:0005790 smooth endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0006457 protein folding;GO:0072583 clathrin-dependent endocytosis;GO:0036503 ERAD pathway;GO:0048488 synaptic vesicle endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P35565-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48675-1", "uniprot_id": [ { "id": "DESM_RAT", "url": "https://www.uniprot.org/uniprot/P48675", "type": "external" } ], "mass": 53457.0, "length": 469, "protein_name": "Desmin", "gene_name": "Des", "organism": "Rat", "refseq_name": "desmin", "refseq_ac": [ { "id": "NP_071976", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071976", "type": "external" } ], "gene_names_uniprotkb": "Des", "gene_names_refseq": "Des", "protein_names_uniprotkb": "Desmin", "protein_names_refseq": "desmin", "tax_id": 10116, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); cardiomyopathy (Disease Ontology:DOID:0050700); myofibrillar myopathy 1 (Disease Ontology:DOID:0080092); dilated cardiomyopathy 1I (Disease Ontology:DOID:0110431); neurogenic scapuloperoneal syndrome Kaeser type (Disease Ontology:DOID:0111551); dilated cardiomyopathy (Disease Ontology:DOID:12930); restrictive cardiomyopathy (Disease Ontology:DOID:397); mitral valve prolapse (Disease Ontology:DOID:988)", "pathway": " (rno:64362); (R-RNO-390522)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "22673903;23110217;23615443;29987122;30344511;31794771;34100182;34411340;34502162;36603297;8286410;8900395", "class_list": "", "function": "A mutation in desmin makes skeletal muscle less vulnerable to acute muscle damage after eccentric loading in rats., [RefSeq, PubMed]; Aberrant mitochondrial fission results in mitochondrial respiratory defects and apoptotic cell death in D7-Des Tg hearts. Inhibition of aberrant mitochondrial fission using mitochondrial division inhibitor significantly preserved mitochondrial function and decreased apoptotic cell death Publication Status: Online-Only, [RefSeq, PubMed]; Desmin participates in the mechanoelectric feedback in heart failure through the NF-kappaB pathway., [RefSeq, PubMed]; Differential expression of desmin in the uterine myometrium and cervix as a possible mechanism for successful parturition in rats., [RefSeq, PubMed]; Micro-RNA-338-3p Promotes the Development of Atherosclerosis by Targeting Desmin and Promoting Proliferation., [RefSeq, PubMed]; Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Required for nuclear membrane integrity, via anchoring at the cell tip and nuclear envelope, resulting in maintenance of microtubule-derived intracellular mechanical forces (By similarity). Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0042802 identical protein binding;GO:0008092 cytoskeletal protein binding", "go_cellular_component": "GO:0051286 cell tip;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005856 cytoskeleton", "go_biological_process": "GO:0060538 skeletal muscle organ development;GO:0045109 intermediate filament organization;GO:0006998 nuclear envelope organization", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P48675-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52481-1", "uniprot_id": [ { "id": "CAP2_RAT", "url": "https://www.uniprot.org/uniprot/P52481", "type": "external" } ], "mass": 52912.0, "length": 477, "protein_name": "Adenylyl cyclase-associated protein 2", "gene_name": "Cap2", "organism": "Rat", "refseq_name": "adenylyl cyclase-associated protein 2", "refseq_ac": [ { "id": "NP_446326", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446326", "type": "external" } ], "gene_names_uniprotkb": "Cap2", "gene_names_refseq": "Cap2", "protein_names_uniprotkb": "Adenylyl cyclase-associated protein 2; CAP 2", "protein_names_refseq": "CAP 2; CAP, adenylate cyclase-associated protein, 2; adenylyl cyclase-associated protein 2", "tax_id": 10116, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (rno:116653)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;8522189", "class_list": "", "function": "Involved in the regulation of actin polymerization., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0042802 identical protein binding;GO:0008179 adenylate cyclase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0098794 postsynapse", "go_biological_process": "GO:0007015 actin filament organization;GO:0000902 cell morphogenesis;GO:0030036 actin cytoskeleton organization;GO:0007010 cytoskeleton organization;GO:0099140 presynaptic actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P52481-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70486-1", "uniprot_id": [ { "id": "ATRX_RAT", "url": "https://www.uniprot.org/uniprot/P70486", "type": "external" } ], "mass": 59259.0, "length": 527, "protein_name": "Chromatin remodeler ATRX", "gene_name": "Atrx", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Atrx", "gene_names_refseq": "", "protein_names_uniprotkb": "Chromatin remodeler ATRX; 3.6.4.-; Transcriptional regulator ATRX; X-linked nuclear protein; pABP-2", "protein_names_refseq": "", "tax_id": 10116, "disease": "X-linked intellectual disability-hypotonic facies syndrome-1 (Disease Ontology:DOID:0080982); alpha thalassemia-X-linked intellectual disability syndrome (Disease Ontology:DOID:0110030); alpha-thalassemia myelodysplasia syndrome (Disease Ontology:DOID:0112125); sarcoma (Disease Ontology:DOID:1115); islet cell tumor (Disease Ontology:DOID:1799); melanoma (Disease Ontology:DOID:1909); glioblastoma (Disease Ontology:DOID:3068); malignant astrocytoma (Disease Ontology:DOID:3069); high grade glioma (Disease Ontology:DOID:3070); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung adenocarcinoma (Disease Ontology:DOID:3910); lung small cell carcinoma (Disease Ontology:DOID:5409)", "pathway": " (rno:246284)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;8667030", "class_list": "", "function": "Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells probably implying recruitment of CBX5 to telomeres. May be involved in transcriptional regulation of telomeric repeat-containing RNA (TERRA). Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCF within the H19 imprinting control region (ICR) and involved in establishment of histone tails modifications in the ICR. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0016604 nuclear body;GO:0016605 PML body", "go_biological_process": "GO:0031509 subtelomeric heterochromatin formation;GO:0006281 DNA repair;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P70486-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97846-1", "uniprot_id": [ { "id": "CNTP1_RAT", "url": "https://www.uniprot.org/uniprot/P97846", "type": "external" } ], "mass": 155868.0, "length": 1381, "protein_name": "Contactin-associated protein 1", "gene_name": "Cntnap1", "organism": "Rat", "refseq_name": "contactin-associated protein 1 precursor", "refseq_ac": [ { "id": "NP_114450", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114450", "type": "external" } ], "gene_names_uniprotkb": "Cntnap1; Caspr; Nrxn4", "gene_names_refseq": "Caspr; Cntnap1", "protein_names_uniprotkb": "Contactin-associated protein 1; Caspr1; Caspr; Neurexin IV; Neurexin-4; Paranodin; p190", "protein_names_refseq": "caspr1; contactin-associated protein 1 precursor; neurexin IV; neurexin-4; p190; paranodin", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal recessive intellectual developmental disorder (Disease Ontology:DOID:0060308); lethal congenital contracture syndrome (Disease Ontology:DOID:0060558)", "pathway": " (rno:84008)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1039/D0MO00044B;11512672;22673903;24090084;29895952;30010864;34106099;38843836;9118959;9292722;9396755", "class_list": "", "function": "E. coli exploits Caspr1 as a host receptor for penetration of the blood-brain barrier, resulting in meningitis Publication Status: Online-Only, [RefSeq, PubMed]; Required, with CNTNAP2, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the paranodal region of the axo-glial junction. In association with contactin involved in the signaling between axons and myelinating glial cells., [UniProtKB, UniProtKB]; The physical interaction, co-distribution and functional role of Caspr1-mGlu5R interplay in memory formation was characterized., [RefSeq, PubMed]", "predicted_glycosites": 13, "predicted_n_glycosites": 12, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 3, "glyco_site_count": 18, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0030424 axon;GO:0045202 synapse;GO:0048786 presynaptic active zone", "go_biological_process": "GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0007399 nervous system development;GO:0007409 axonogenesis;GO:0022010 central nervous system myelination", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P97846-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q01134-1", "uniprot_id": [ { "id": "CHKA_RAT", "url": "https://www.uniprot.org/uniprot/Q01134", "type": "external" } ], "mass": 51824.0, "length": 453, "protein_name": "Choline kinase alpha", "gene_name": "Chka", "organism": "Rat", "refseq_name": "choline kinase alpha isoform 2", "refseq_ac": [ { "id": "NP_058823", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058823", "type": "external" } ], "gene_names_uniprotkb": "Chka; Chk; Ckr", "gene_names_refseq": "CK-R; Chka; Chk", "protein_names_uniprotkb": "Choline kinase alpha; 2.7.1.32; 2.7.1.82; CHETK-alpha; CK; EK; Ethanolamine kinase", "protein_names_refseq": "CHETK-alpha; CK; EK; choline kinase R; choline kinase alpha isoform 2; ethanolamine kinase", "tax_id": 10116, "disease": "colon adenoma (Disease Ontology:DOID:0050912); microcephaly (Disease Ontology:DOID:10907); epilepsy (Disease Ontology:DOID:1826); colon cancer (Disease Ontology:DOID:219); transient cerebral ischemia (Disease Ontology:DOID:224)", "pathway": " (rno:29194); (R-RNO-1483191); (R-RNO-1483213)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "1577786;22673903;7852267", "class_list": "", "function": "Plays a key role in phospholipid biosynthesis by catalyzing the phosphorylation of free choline to phosphocholine, the first step in phosphatidylcholine biosynthesis. Also phosphorylates ethanolamine, thereby contributing to phosphatidylethanolamine biosynthesis. Has higher activity with choline., [UniProtKB, UniProtKB]; This isoform plays a key role in lipolysis of lipid droplets following glucose deprivation (By similarity). In response to glucose deprivation, phosphorylated by AMPK, promoting localization to lipid droplets (By similarity). Phosphorylation is followed by acetylation by KAT5, leading to dissociation of the homodimer into a monomer (By similarity). Monomeric CHKA isoform 1 is converted into a tyrosine-protein kinase, which phosphorylates lipid droplet structural proteins PLIN2 and PLIN3, leading to lipolysis of lipid droplets (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q63114", "ec_number_list": [ { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" } ], "go_molecular_function": "GO:0033265 choline binding;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0005829 cytosol", "go_biological_process": "GO:0019695 choline metabolic process;GO:0006580 ethanolamine metabolic process;GO:0006657 CDP-choline pathway;GO:1904681 response to 3-methylcholanthrene;GO:0006656 phosphatidylcholine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q01134-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1WIM2-1", "uniprot_id": [ { "id": "CADM2_RAT", "url": "https://www.uniprot.org/uniprot/Q1WIM2", "type": "external" } ], "mass": 47528.0, "length": 435, "protein_name": "Cell adhesion molecule 2", "gene_name": "Cadm2", "organism": "Rat", "refseq_name": "cell adhesion molecule 2 precursor", "refseq_ac": [ { "id": "NP_001040567", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040567", "type": "external" } ], "gene_names_uniprotkb": "Cadm2; Igsf4d; Necl3", "gene_names_refseq": "Cadm2; Igsf4d; Necl-3; SynCAM 2", "protein_names_uniprotkb": "Cell adhesion molecule 2; IgSF4D; Immunoglobulin superfamily member 4D; NECL-3; Nectin-like protein 3; SynCAM 2; Synaptic cell adhesion molecule 2", "protein_names_refseq": "cell adhesion molecule 2 precursor; immunoglobulin superfamily member 4D; immunoglobulin superfamily, member 4; nectin-like protein 3; synaptic cell adhesion molecule 2", "tax_id": 10116, "disease": "", "pathway": " (rno:360687); (R-RNO-418990)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "17967169;22673903;24090084;29039453", "class_list": "", "function": "Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes (By similarity)., [UniProtKB]; Overexpression of miR125a reduced the level of Cadm2 expression in PC12 cell injury induced by free-serum. In contrast, inhibition of miR125a using miR125a inhibitors significantly resulted in higher levels of Cadm2 expression. In conclusion, miR125a is involved in the behavioral disorder of animal models of MCAO by regulation of Cadm2., [RefSeq, PubMed]; We show that Necl-3/SynCAM-2 is a plasma membrane protein that accumulates in several tissues, including those of the central and peripheral nervous system. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 15, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0030424 axon;GO:0045211 postsynaptic membrane;GO:0032809 neuronal cell body membrane", "go_biological_process": "GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0099560 synaptic membrane adhesion", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q1WIM2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3MKP9-1", "uniprot_id": [ { "id": "BEX4_RAT", "url": "https://www.uniprot.org/uniprot/Q3MKP9", "type": "external" } ], "mass": 13721.0, "length": 118, "protein_name": "Protein BEX4", "gene_name": "Bex4", "organism": "Rat", "refseq_name": "protein BEX4", "refseq_ac": [ { "id": "NP_001032643", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032643", "type": "external" } ], "gene_names_uniprotkb": "Bex4", "gene_names_refseq": "Bex4", "protein_names_uniprotkb": "Protein BEX4; Brain-expressed X-linked protein 4", "protein_names_refseq": "BEX1-like 1; BEX1-like protein 1; brain expressed gene 4; brain-expressed X-linked protein 4 homolog; protein BEX4", "tax_id": 10116, "disease": "", "pathway": " (rno:501624)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15958283;34576008", "class_list": "", "function": "BEX1 and BEX4 Induce GBM Progression through Regulation of Actin Polymerization and Activation of YAP/TAZ Signaling. Publication Status: Online-Only, [RefSeq, PubMed]; May play a role in microtubule deacetylation by negatively regulating the SIRT2 deacetylase activity toward alpha-tubulin and thereby participate in the control of cell cycle progression and genomic stability (By similarity). In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1A5L0", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0042826 histone deacetylase binding;GO:0043014 alpha-tubulin binding;GO:0140678 molecular function inhibitor activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0007059 chromosome segregation;GO:0042127 regulation of cell population proliferation;GO:0007346 regulation of mitotic cell cycle;GO:0030334 regulation of cell migration;GO:0031397 negative regulation of protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3MKP9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q564G3-1", "uniprot_id": [ { "id": "DEGS2_RAT", "url": "https://www.uniprot.org/uniprot/Q564G3", "type": "external" } ], "mass": 37441.0, "length": 323, "protein_name": "Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2", "gene_name": "Degs2", "organism": "Rat", "refseq_name": "sphingolipid delta(4)-desaturase/C4-monooxygenase DES2", "refseq_ac": [ { "id": "NP_001017457", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017457", "type": "external" } ], "gene_names_uniprotkb": "Degs2; Des2", "gene_names_refseq": "Degs2; RGD1305023", "protein_names_uniprotkb": "Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2; 1.14.18.5; 1.14.19.17; Degenerative spermatocyte homolog 2; Sphingolipid 4-desaturase; Sphingolipid C4-monooxygenase", "protein_names_refseq": "sphingolipid 4-desaturase; sphingolipid C4-hydroxylase/delta 4-desaturase; sphingolipid C4-monooxygenase; sphingolipid delta(4)-desaturase/C4-hydroxylase DES2; sphingolipid delta(4)-desaturase/C4-monooxygenase DES2", "tax_id": 10116, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:314438); (R-RNO-1660661)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "17716801;21914808", "class_list": "", "function": "Bifunctional enzyme which acts both as a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase., [UniProtKB, UniProtKB]; Overexpression of DEGS1 or DEGS2 attenuates the DHC accumulation and increased cell proliferation during hypoxia Erratum:[J Biol Chem. 2012 May 18;287(21):17425], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.19.17", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.17", "type": "external" }, { "id": "1.14.18.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.18.5", "type": "external" }, { "id": "5.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0042284 sphingolipid delta-4 desaturase activity;GO:0102772 sphingolipid C4-monooxygenase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0046513 ceramide biosynthetic process;GO:0030148 sphingolipid biosynthetic process;GO:0006667 sphinganine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q564G3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M876-1", "uniprot_id": [ { "id": "ACY3_RAT", "url": "https://www.uniprot.org/uniprot/Q5M876", "type": "external" } ], "mass": 35419.0, "length": 319, "protein_name": "N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)", "gene_name": "Acy3", "organism": "Rat", "refseq_name": "N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)", "refseq_ac": [ { "id": "NP_001009603", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009603", "type": "external" } ], "gene_names_uniprotkb": "Acy3", "gene_names_refseq": "Acy3; RGD1305394", "protein_names_uniprotkb": "N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming); 3.5.1.114; ACY-3; Aminoacylase-3; Aspartoacylase-2", "protein_names_refseq": "ACY-3; N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming); aspartoacylase (aminoacylase) 3; aspartoacylase (aminocyclase) 3; aspartoacylase 3; aspartoacylase-2", "tax_id": 10116, "disease": "", "pathway": " (rno:293653); (R-RNO-5423646)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22673903;22819785", "class_list": "", "function": "Plays an important role in deacetylating mercapturic acids in kidney proximal tubules. Also acts on N-acetyl-aromatic amino acids (By similarity)., [UniProtKB]; We report a new potential mechanism for neuronal damage in Alzheimer disease that involves AA3; This previously unrecognized mechanism may also function in Parkinson disease, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.1.114", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.114", "type": "external" }, { "id": "3.5.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.14", "type": "external" } ], "go_molecular_function": "GO:0004046 aminoacylase activity;GO:0016788 hydrolase activity, acting on ester bonds;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0016324 apical plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5M876-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62717-1", "uniprot_id": [ { "id": "CAPS1_RAT", "url": "https://www.uniprot.org/uniprot/Q62717", "type": "external" } ], "mass": 146266.0, "length": 1289, "protein_name": "Calcium-dependent secretion activator 1", "gene_name": "Cadps", "organism": "Rat", "refseq_name": "calcium-dependent secretion activator 1", "refseq_ac": [ { "id": "NP_037351", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037351", "type": "external" } ], "gene_names_uniprotkb": "Cadps; Caps1; Caps", "gene_names_refseq": "Cadps; Caps1; Caps2; Caps", "protein_names_uniprotkb": "Calcium-dependent secretion activator 1; CAPS-1; Calcium-dependent activator protein for secretion 1; rCAPS", "protein_names_refseq": "CAPS-1; Ca++-dependent secretion activator; Ca2+ dependent secretion activator; Ca2+-dependent activator protein; Ca<2+-dependent activator protein for secretion; calcium-dependent activator protein for secretion 1; calcium-dependent secretion activator 1-like; calcium-dependent secretion activator 1; rCAPS", "tax_id": 10116, "disease": "", "pathway": " (rno:26989)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10792045;11927595;14530279;1516133;15312653;18683930;19460754;22673903;26700319;27528604;29393594;33580180;9162085;9289490;9525942;9697858;9697859", "class_list": "", "function": "Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Down-regulation of habenular calcium-dependent secretion activator 2 induces despair-like behavior. Publication Status: Online-Only, [RefSeq, PubMed]; Results indicate that dense-core vesicles carry CAPS to sites of exocytosis, where CAPS promotes vesicle docking and fusion competence, probably by initiating SNARE complex assembly., [RefSeq, PubMed]; The unique tandem C2-PH domain of CAPS may serve as a PI(4,5)P2-triggered switch for dimerization. CAPS dimerization may be coupled to oligomeric SNARE complex assembly for vesicle docking and priming., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0019901 protein kinase binding;GO:0005509 calcium ion binding;GO:0046872 metal ion binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0031410 cytoplasmic vesicle;GO:0098793 presynapse;GO:0098674 extrinsic component of neuronal dense core vesicle membrane", "go_biological_process": "GO:0015031 protein transport;GO:0045055 regulated exocytosis;GO:0016050 vesicle organization;GO:0006887 exocytosis;GO:0017156 calcium-ion regulated exocytosis", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q62717-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63369-1", "uniprot_id": [ { "id": "NFKB1_RAT", "url": "https://www.uniprot.org/uniprot/Q63369", "type": "external" } ], "mass": 105704.0, "length": 973, "protein_name": "Nuclear factor NF-kappa-B p105 subunit", "gene_name": "Nfkb1", "organism": "Rat", "refseq_name": "nuclear factor NF-kappa-B p105 subunit isoform 1", "refseq_ac": [ { "id": "NP_001401941", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001401941", "type": "external" } ], "gene_names_uniprotkb": "Nfkb1", "gene_names_refseq": "EBP-1; NF-kB; NFKB-p50; Nfkb1; p50", "protein_names_uniprotkb": "Nuclear factor NF-kappa-B p105 subunit; DNA-binding factor KBF1; EBP-1; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1", "protein_names_refseq": "DNA-binding factor KBF1; nuclear factor NF-kappa-B p105 subunit isoform 1; nuclear factor NF-kappa-B p105 subunit; nuclear factor NF-kappa-B p50; nuclear factor of kappa light chain gene enhancer in B-cells 1, p105; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105", "tax_id": 10116, "disease": "metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); common variable immunodeficiency 12 (Disease Ontology:DOID:0081154); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); alcoholic hepatitis (Disease Ontology:DOID:12351); lung cancer (Disease Ontology:DOID:1324); breast cancer (Disease Ontology:DOID:1612); melanoma (Disease Ontology:DOID:1909); transient cerebral ischemia (Disease Ontology:DOID:224); HTLV-1-associated myelopathy/tropical spastic paraparesis (Disease Ontology:DOID:321); lung non-small cell carcinoma (Disease Ontology:DOID:3908); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); hepatocellular carcinoma (Disease Ontology:DOID:684); collagen disease (Disease Ontology:DOID:854); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (R-RNO-1169091); (R-RNO-1810476); (R-RNO-193692); (R-RNO-202424); (R-RNO-209560); (R-RNO-2871837); (R-RNO-3134963); (R-RNO-3214841); (R-RNO-445989); (R-RNO-448706); (R-RNO-5607764); (R-RNO-5621575); (R-RNO-5684264); (R-RNO-6798695); (R-RNO-9020702); (R-RNO-933542); (R-RNO-9860927); (R-RNO-9958825)", "pathway_count": 18, "publication_count": 7, "publication_id_list": "22673903;38302679;38334011;38466011;38788361;38850784;8161377", "class_list": "", "function": "Alpha7nAChR Activation Combined with Endothelial Progenitor Cell Transplantation Attenuates Lung Injury in Diabetic Rats with Sepsis through the NF-kappaB Pathway., [RefSeq, PubMed]; Constitutes the active form, which associates with RELA/p65 to form the NF-kappa-B p65-p50 complex to form a transcription factor. Together with RELA/p65, binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Echinatin alleviates inflammation and pyroptosis in hypoxic-ischemic brain damage by inhibiting TLR4/ NF-kappaB pathway., [RefSeq, PubMed]; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. In a complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105., [UniProtKB, UniProtKB]; P105 is the precursor of the active p50 subunit (Nuclear factor NF-kappa-B p50 subunit) of the nuclear factor NF-kappa-B. Acts as a cytoplasmic retention of attached NF-kappa-B proteins by p105., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Protein tyrosine phosphatase 1B contributes to neuropathic pain by aggravating NF-kappaB and glial cells activation-mediated neuroinflammation via promoting endoplasmic reticulum stress. Erratum:[CNS Neurosci Ther. 2025 Aug;31(8):e70557. doi: 10.1111/cns.70557. PMID: 40755269], [RefSeq, PubMed]; Suppression of microRNA-320 Induces Cerebral Protection Against Ischemia/Reperfusion Injury by Targeting HMGB1/NF-kappaB Axis., [RefSeq, PubMed]; The involvement of oxidative stress and the TLR4/NF-kappaB/NLRP3 pathway in acute lung injury induced by high-altitude hypoxia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1LQH2", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0031072 heat shock protein binding", "go_cellular_component": "GO:0033256 I-kappaB/NF-kappaB complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:1904385 cellular response to angiotensin;GO:1990416 cellular response to brain-derived neurotrophic factor stimulus;GO:0010957 negative regulation of vitamin D biosynthetic process;GO:0071359 cellular response to dsRNA", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q63369-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66HA5-1", "uniprot_id": [ { "id": "C2D1A_RAT", "url": "https://www.uniprot.org/uniprot/Q66HA5", "type": "external" } ], "mass": 103587.0, "length": 941, "protein_name": "Coiled-coil and C2 domain-containing protein 1A", "gene_name": "Cc2d1a", "organism": "Rat", "refseq_name": "coiled-coil and C2 domain-containing protein 1A isoform 1", "refseq_ac": [ { "id": "NP_001013891", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013891", "type": "external" } ], "gene_names_uniprotkb": "Cc2d1a", "gene_names_refseq": "Cc2d1a; RGD1306108", "protein_names_uniprotkb": "Coiled-coil and C2 domain-containing protein 1A; FRE under dual repression-binding protein 1; Five prime repressor element under dual repression-binding protein 1; Freud-1", "protein_names_refseq": "FRE under dual repression-binding protein 1; coiled-coil and C2 domain-containing protein 1A isoform 1; coiled-coil and C2 domain-containing protein 1A; five prime repressor element under dual repression-binding protein 1; five repressor element under dual repression-binding protein 1; freud-1", "tax_id": 10116, "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545); syndromic intellectual disability (Disease Ontology:DOID:0050888); ciliopathy (Disease Ontology:DOID:0060340); autosomal recessive intellectual developmental disorder 3 (Disease Ontology:DOID:0081179); intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (rno:288908)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12917378;19647046;22673903;24946016;27150226;38843836", "class_list": "", "function": "Freud-1 and Freud-2 levels were different in rats selectively bred for 85 generations for either high level of fear-induced aggression or its absence. Freud-1 protein level was decreased in the hippocampus, whereas Freud-2 protein level was increased in the frontal cortex of highly aggressive rats. There no differences in 5-HT1A receptor gene expression were found in the brains of highly aggressive and nonaggressive rats., [RefSeq, PubMed]; In pregnancy stress, prefrontal cortex Cc2d1a levels were reduced in rats., [RefSeq, PubMed]; Results point to the importance of understanding the mechanism for the differential regulation of 5-HT1AR, Freud-1 and NUDR in the prefrontal cortex as a basis for understanding the related effects of chronic stress and stress-related disorders, [RefSeq, PubMed]; Transcription factor that binds specifically to the DRE (dual repressor element) and represses 5-HT1A gene transcription though this element. Mediates HDAC-independent repression of HTR1A promoter. CAMK2G inhibits CC2D1a-induced repression of the HTR1A. May play a role in the altered regulation of 5-HT1A receptors associated with anxiety and major depression. Performs essential function in controlling functional maturation of synapses (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0045202 synapse", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0002087 regulation of respiratory gaseous exchange by nervous system process;GO:0140059 dendrite arborization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q66HA5-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q695P6-1", "uniprot_id": [ { "id": "C5AR2_RAT", "url": "https://www.uniprot.org/uniprot/Q695P6", "type": "external" } ], "mass": 38123.0, "length": 343, "protein_name": "C5a anaphylatoxin chemotactic receptor 2", "gene_name": "C5ar2", "organism": "Rat", "refseq_name": "C5a anaphylatoxin chemotactic receptor 2", "refseq_ac": [ { "id": "NP_001003710", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003710", "type": "external" } ], "gene_names_uniprotkb": "C5ar2; C5l2; Gpr77", "gene_names_refseq": "C5L2; C5ar2; Gpr77", "protein_names_uniprotkb": "C5a anaphylatoxin chemotactic receptor 2; Complement component 5a receptor 2; G protein-coupled receptor 77", "protein_names_refseq": "C5A receptor beta; C5a anaphylatoxin chemotactic receptor 2; C5a anaphylatoxin chemotactic receptor C5L2; G protein-coupled receptor 77; complement 5A receptor beta; complement component 5a receptor 2", "tax_id": 10116, "disease": "", "pathway": " (rno:445269); (R-RNO-375276); (R-RNO-977606)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "15634936;15715664;15784721;17158873;19020281;22099750;22673903;29393594", "class_list": "", "function": "A C5aR isoform expressed by glia and neurons is regulated by NA and exerts anti-inflammatory functions. Changes in C5aR isoform levels in diseased brain could therefore contribute to the progression of inflammatory damage., [RefSeq, PubMed]; C5L2 appears to bind complement factor C5a and its C-terminal cleavage product C5a des Arg by different mechanisms, and, unlike C5a receptor (C5aR), C5L2 uses critical residues in its N-terminal domain for binding only to C5a des Arg., [RefSeq, PubMed]; C5a receptors and C5L2 were demonstrated in the rat anterior pituitary gland and they may play a role in dampening down inflammation by inhibiting the release of MIF and stimulating the release of ACTH., [RefSeq, PubMed]; C5aR and C5L2, but not C3aR, are expressed on CD11b-positive leukocytes in islet preparations, [RefSeq, PubMed]; Data provide the first evidence for a role for C5a receptor C5L2 in balancing the biological responses to Complement 5a, [RefSeq, PubMed]; Following cecal ligation and puncture-induced sepsis in rats, neutrophils demonstrated a time-dependent decrease in C5L2., [RefSeq, PubMed]; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a, stimulating chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production. Also acts as a receptor for dearginated forms of C3a, C4a and C5a anaphylatoxin peptides (ASP/C3adesArg, C4adesArg and C5adesArg, respectively). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. C5AR1 is coupled to G(i)/G(o) (GNAI1 or GNAO1) G alpha proteins and mediates inhibition of adenylate cyclase., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004878 complement component C5a receptor activity;GO:0004875 complement receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0045177 apical part of cell;GO:0009925 basal plasma membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0002430 complement receptor mediated signaling pathway;GO:0006954 inflammatory response;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0032715 negative regulation of interleukin-6 production", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q695P6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYT5-1", "uniprot_id": [ { "id": "ARMT1_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYT5", "type": "external" } ], "mass": 50184.0, "length": 439, "protein_name": "Damage-control phosphatase 1", "gene_name": "Dcph1", "organism": "Rat", "refseq_name": "damage-control phosphatase 1", "refseq_ac": [ { "id": "NP_001017447", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017447", "type": "external" } ], "gene_names_uniprotkb": "Dcph1; Armt1", "gene_names_refseq": "Armt1; Dcph1; RGD1305235", "protein_names_uniprotkb": "Damage-control phosphatase 1; 2.1.1.-; 3.1.3.-; Acidic residue methyltransferase 1; Protein-glutamate O-methyltransferase; Sugar phosphate phosphatase ARMT1", "protein_names_refseq": "UPF0364 protein C6orf211 homolog; acidic residue methyltransferase 1; damage-control phosphatase 1; damage-control phosphatase ARMT1; protein-glutamate O-methyltransferase; sugar phosphate phosphatase ARMT1", "tax_id": 10116, "disease": "", "pathway": " (rno:292267)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate (By similarity). Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism (By similarity). Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues (By similarity). Possibly methylates PCNA, suggesting it is involved in the DNA damage response (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.94", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.94", "type": "external" }, { "id": "3.1.3.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.25", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0019899 enzyme binding;GO:0046872 metal ion binding;GO:0008757 S-adenosylmethionine-dependent methyltransferase activity;GO:0051998 protein carboxyl O-methyltransferase activity;GO:0016791 phosphatase activity", "go_cellular_component": "", "go_biological_process": "GO:0006974 DNA damage response;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AYT5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6MG11-1", "uniprot_id": [ { "id": "ATAT_RAT", "url": "https://www.uniprot.org/uniprot/Q6MG11", "type": "external" } ], "mass": 47327.0, "length": 421, "protein_name": "Alpha-tubulin N-acetyltransferase 1", "gene_name": "Atat1", "organism": "Rat", "refseq_name": "alpha-tubulin N-acetyltransferase 1", "refseq_ac": [ { "id": "NP_997663", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997663", "type": "external" } ], "gene_names_uniprotkb": "Atat1; ATAT1; MEC17; Mec17", "gene_names_refseq": "3110080J08Rik; Atat1; Mec17; RGD1303066; TAT", "protein_names_uniprotkb": "Alpha-tubulin N-acetyltransferase 1; 2.3.1.108; Acetyltransferase mec-17 homolog; Alpha-TAT1; Alpha-TAT; TAT", "protein_names_refseq": "acetyltransferase mec-17 homolog; alpha-TAT1; alpha-TAT; alpha-tubulin N-acetyltransferase 1", "tax_id": 10116, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (rno:361789); (R-RNO-5620920)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "15060004;22673903;22972992;26700226;27314403;28505206;33626373;38897390", "class_list": "", "function": "Eml1 promotes axonal growth by enhancing alphaTAT1-mediated microtubule acetylation., [RefSeq, PubMed]; HAGLR aggravates neuropathic pain and promotes inflammatory response and apoptosis of lipopolysaccharide-treated SH-SY5Y cells by sequestering miR-182-5p from ATAT1 and activating NLRP3 inflammasome., [RefSeq, PubMed]; Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These results agree with the hypothesis that the acetylation of alpha-tubulin by ATAT1 regulates the intracellular transport of secretory granules in corticotrophs., [RefSeq, PubMed]; These results indicated that alpha-tubulin acetylation by ATAT1 at distinct subcellular positions may influence the functional regulation of microtubules and cilia in a variety of ciliated cells., [RefSeq, PubMed]; This finding reveals the importance of MEC-17 and alpha-tubulin acetylation in cortical development., [RefSeq, PubMed]; While alphaTAT1 may be important for axonal growth in vitro, neither alphaTAT1 nor HDAC5 had an effect in vivo on the regeneration of sciatic nerves. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.108", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.108", "type": "external" } ], "go_molecular_function": "GO:0016407 acetyltransferase activity;GO:0004468 L-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor;GO:0019799 tubulin N-acetyltransferase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005874 microtubule;GO:0005905 clathrin-coated pit;GO:0005925 focal adhesion;GO:0016020 membrane", "go_biological_process": "GO:0007283 spermatogenesis;GO:0009612 response to mechanical stimulus;GO:0000226 microtubule cytoskeleton organization;GO:0048666 neuron development;GO:0048265 response to pain", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6MG11-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80ZG6-1", "uniprot_id": [ { "id": "BBC3_RAT", "url": "https://www.uniprot.org/uniprot/Q80ZG6", "type": "external" } ], "mass": 20718.0, "length": 193, "protein_name": "Bcl-2-binding component 3", "gene_name": "Bbc3", "organism": "Rat", "refseq_name": "bcl-2-binding component 3", "refseq_ac": [ { "id": "NP_776209", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776209", "type": "external" } ], "gene_names_uniprotkb": "Bbc3; Puma", "gene_names_refseq": "Bbc3; Puma", "protein_names_uniprotkb": "Bcl-2-binding component 3; p53 up-regulated modulator of apoptosis", "protein_names_refseq": "bcl-2-binding component 3; p53 up-regulated modulator of apoptosis", "tax_id": 10116, "disease": "transient cerebral ischemia (Disease Ontology:DOID:224); intermittent claudication (Disease Ontology:DOID:3669); lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (rno:317673)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12787069;17998337;27117005;31878844;37088760;39305937", "class_list": "", "function": "Cdc25A phosphatase is activated and mediates neuronal cell death by PUMA via pRb/E2F1 pathway in a model of Parkinson's disease., [RefSeq, PubMed]; Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis. Promotes partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53, releasing the bound p53/TP53 to induce apoptosis. Regulates ER stress-induced neuronal apoptosis., [UniProtKB, UniProtKB, UniProtKB]; LncRNAGAS5 sponges miRNA-221 to promote neurons apoptosis by up-regulated PUMA under hypoxia condition., [RefSeq, PubMed]; These results demonstrated the involvement of BBC3/Bbc3 in cold preservation/rewarming-mediated islet injury, possibly through modulating HMGB1- and oxidative stress-mediated injury to islets., [RefSeq, PubMed]; [Effects of PUMA knockout on the apoptosis of H9C2 cardiomyocytes induced by high glucose]., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051117 ATPase binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005764 lysosome", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0097190 apoptotic signaling pathway;GO:0070245 positive regulation of thymocyte apoptotic process;GO:0071456 cellular response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q80ZG6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VIB2-1", "uniprot_id": [ { "id": "DAXX_RAT", "url": "https://www.uniprot.org/uniprot/Q8VIB2", "type": "external" } ], "mass": 80687.0, "length": 731, "protein_name": "Death domain-associated protein 6", "gene_name": "Daxx", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Daxx", "gene_names_refseq": "", "protein_names_uniprotkb": "Death domain-associated protein 6; Daxx", "protein_names_refseq": "", "tax_id": 10116, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); lung non-squamous non-small cell carcinoma (Disease Ontology:DOID:0080521); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); appendiceal neoplasm (Disease Ontology:DOID:11240); leukemia (Disease Ontology:DOID:1240); neuroendocrine tumor (Disease Ontology:DOID:169); pancreatic endocrine carcinoma (Disease Ontology:DOID:1798); islet cell tumor (Disease Ontology:DOID:1799); ovary epithelial cancer (Disease Ontology:DOID:2152); transient cerebral ischemia (Disease Ontology:DOID:224); colon adenocarcinoma (Disease Ontology:DOID:234); transitional cell carcinoma (Disease Ontology:DOID:2671); clear cell adenocarcinoma (Disease Ontology:DOID:4468)", "pathway": " (rno:140926); (R-RNO-3899300); (R-RNO-6804757)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53 stabilization. Acts as a histone chaperone that facilitates deposition of histone H3.3. Acts as a targeting component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Does not affect the ATPase activity of ATRX but alleviates its transcription repression activity. Upon neuronal activation associates with regulatory elements of selected immediate early genes where it promotes deposition of histone H3.3 which may be linked to transcriptional induction of these genes. Required for the recruitment of histone H3.3:H4 dimers to PML-nuclear bodies (PML-NBs); the process is independent of ATRX and facilitated by ASF1A; PML-NBs are suggested to function as regulatory sites for the incorporation of newly synthesized histone H3.3 into chromatin. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. Plays a role as a positive regulator of the heat shock transcription factor HSF1 activity during the stress protein response (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0019899 enzyme binding;GO:0019901 protein kinase binding;GO:0042803 protein homodimerization activity;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0005874 microtubule", "go_biological_process": "GO:0030578 PML body organization;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0008283 cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VIB2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q920K5-1", "uniprot_id": [ { "id": "BAALC_RAT", "url": "https://www.uniprot.org/uniprot/Q920K5", "type": "external" } ], "mass": 15475.0, "length": 145, "protein_name": "Brain and acute leukemia cytoplasmic protein", "gene_name": "Baalc", "organism": "Rat", "refseq_name": "brain and acute leukemia cytoplasmic protein", "refseq_ac": [ { "id": "NP_658907", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_658907", "type": "external" } ], "gene_names_uniprotkb": "Baalc", "gene_names_refseq": "Baalc", "protein_names_uniprotkb": "Brain and acute leukemia cytoplasmic protein", "protein_names_refseq": "BAALC, MAP3K1 and KLF4 binding; brain and acute leukemia cytoplasmic protein; brain and acute leukemia, cytoplasmic", "tax_id": 10116, "disease": "", "pathway": " (rno:140720)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11707601;15659234;16376586", "class_list": "", "function": "MRNA differential display analysis identified two genes, viz. BAALC and RAMP3, whose expression is altered in primary astrocytes treated with differentiation inducers., [RefSeq, PubMed]; May play a synaptic role at the postsynaptic lipid rafts possibly through interaction with CAMK2A., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q790N3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0014069 postsynaptic density;GO:0045121 membrane raft;GO:0043005 neuron projection", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q920K5-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ET61-1", "uniprot_id": [ { "id": "C1QR1_RAT", "url": "https://www.uniprot.org/uniprot/Q9ET61", "type": "external" } ], "mass": 68782.0, "length": 643, "protein_name": "Complement component C1q receptor", "gene_name": "Cd93", "organism": "Rat", "refseq_name": "complement component C1q receptor precursor", "refseq_ac": [ { "id": "NP_445835", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445835", "type": "external" } ], "gene_names_uniprotkb": "Cd93; C1qr1; C1qrp", "gene_names_refseq": "C1qRp; C1qr1; Cd93; Ly68", "protein_names_uniprotkb": "Complement component C1q receptor; C1q/MBL/SPA receptor; C1qR(p); C1qRp; Cell surface antigen AA4; Complement component 1 q subcomponent receptor 1", "protein_names_refseq": "C1q/MBL/SPA receptor; C1qR(p); CD93 antigen; cell surface antigen AA4; complement component 1 q subcomponent receptor 1; complement component C1q receptor precursor; complement component C1q receptor; lymphocyte antigen 68", "tax_id": 10116, "disease": "thyroid gland carcinoma (Disease Ontology:DOID:3963)", "pathway": " (rno:84398); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10934210;11093152;22673903;24106277;36197773;36336138", "class_list": "", "function": "Cell surface receptor that plays a role in various physiological processes including inflammation, phagocytosis, and cell adhesion. Plays a role in phagocytosis and enhances the uptake of apoptotic cells and immune complexes by acting as a receptor for defense collagens including surfactant protein A/SFTPA1, C1q, and mannose-binding lectin (MBL2). Plays a role in the regulation of endothelial cell function and adhesion by activating angiogenesis. Mechanistically, exerts its angiogenic function by associating with beta-dystroglycan, leading to SRC-dependent phosphorylation and subsequent recruitment of CBL. In turn, CBL provides a docking site for downstream signaling components, such as CRKL to enhance cell migration. Participates in angiogenesis also by acting as a receptor for the ECM pan-endothelial glycoprotein multimerin-2/MMRN2 and IGFBP7 ligands. Both ligands play a non-redundant role in CD93-mediated endothelial cell function (By similarity). Acts as a key regulator of endothelial barrier function through modulating VEGFR2 function (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Crosstalk between CD93, C1q and GIPC in the Regulation of Pneumococcal Meningitis Inflammation., [RefSeq, PubMed]; Synergistic regulation of microglia differentiation by CD93 and integrin beta1 in the rat pneumococcal meningitis model., [RefSeq, PubMed]; These results indicate that gC1qR is the receptor for TLQP-21 and plays an important role in chronic pain through activation of macrophages, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9JIZ6", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0030246 carbohydrate binding;GO:0001849 complement component C1q complex binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0001525 angiogenesis;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9ET61-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JHL4-1", "uniprot_id": [ { "id": "DBNL_RAT", "url": "https://www.uniprot.org/uniprot/Q9JHL4", "type": "external" } ], "mass": 48613.0, "length": 436, "protein_name": "Drebrin-like protein", "gene_name": "Dbnl", "organism": "Rat", "refseq_name": "drebrin-like protein isoform 1", "refseq_ac": [ { "id": "NP_001264140", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264140", "type": "external" } ], "gene_names_uniprotkb": "Dbnl; Sh3p7", "gene_names_refseq": "Dbnl; Sh3p7; abp1", "protein_names_uniprotkb": "Drebrin-like protein; Abp1; Actin-binding protein 1; SH3 domain-containing protein 7", "protein_names_refseq": "SH3 domain-containing protein 7; actin-binding protein 1; drebrin-like protein isoform 1; drebrin-like protein", "tax_id": 10116, "disease": "", "pathway": " (rno:83527)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11309416;11595038;15014124;17476322;17956734;22673903;23223303;24802081", "class_list": "", "function": "Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Required for the formation of organized podosome rosettes. May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Findings reveal a novel signaling adaptor protein, HIP-55, which negatively regulates the beta-AR-mediated ERK proliferative pathway and Cardia Fibroblast proliferation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JM66;Q9JM67;Q9JM74", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0019904 protein domain specific binding;GO:0051015 actin filament binding;GO:0098973 structural constituent of postsynaptic actin cytoskeleton", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005829 cytosol", "go_biological_process": "GO:0006897 endocytosis;GO:0048812 neuron projection morphogenesis;GO:0007416 synapse assembly;GO:0016601 Rac protein signal transduction;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9JHL4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q29RW1-1", "uniprot_id": [ { "id": "MYH4_RAT", "url": "https://www.uniprot.org/uniprot/Q29RW1", "type": "external" } ], "mass": 222880.0, "length": 1939, "protein_name": "Myosin-4", "gene_name": "Myh1; Myh2; Myh4", "organism": "Rat", "refseq_name": "myosin-4", "refseq_ac": [ { "id": "NP_062198", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062198", "type": "external" } ], "gene_names_uniprotkb": "Myh1; Myh2; Myh4; Myh1", "gene_names_refseq": "Myh4", "protein_names_uniprotkb": "Myosin-4; MyHC-2b; Myosin heavy chain 2b; Myosin heavy chain 4", "protein_names_refseq": "2B myosin heavy chain; myHC-2b; myosin heavy chain 2b; myosin heavy chain type IIb; myosin, heavy chain 4, skeletal muscle; myosin, heavy polypeptide 4, skeletal muscle; myosin-4", "tax_id": 10116, "disease": "distal arthrogryposis (Disease Ontology:DOID:0050646); cardiomyopathy (Disease Ontology:DOID:0050700); familial hypertrophic cardiomyopathy (Disease Ontology:DOID:0080326); congenital myopathy 6 (Disease Ontology:DOID:0080719); dilated cardiomyopathy 1S (Disease Ontology:DOID:0110454); autosomal dominant hyaline body myopathy (Disease Ontology:DOID:0111269); distal arthrogryposis type 1 (Disease Ontology:DOID:0111596); distal arthrogryposis type 2B3 (Disease Ontology:DOID:0111602); distal arthrogryposis type 2A (Disease Ontology:DOID:0111605); sciatic neuropathy (Disease Ontology:DOID:11446); distal myopathy (Disease Ontology:DOID:11720); dilated cardiomyopathy (Disease Ontology:DOID:12930); myotonia congenita (Disease Ontology:DOID:2106); inclusion body myositis (Disease Ontology:DOID:3429); restrictive cardiomyopathy (Disease Ontology:DOID:397); myopathy (Disease Ontology:DOID:423)", "pathway": " (rno:360543); (rno:691644)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "19040707;19260067;22673903;34502162", "class_list": "", "function": "Although the sarcomeric stability of paralyzed muscle might be impaired, moderate mechanical loading does not seem to affect paralyzed muscle protein composition, [RefSeq, PubMed]; Exercise training showed a myosin heavy chain shift from type IIb to IIa skeletal muscles., [RefSeq, PubMed]; Muscle contraction., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 46, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 16, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0003725 double-stranded RNA binding;GO:0000146 microfilament motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0032982 myosin filament;GO:0030016 myofibril;GO:0016460 myosin II complex;GO:0005911 cell-cell junction", "go_biological_process": "GO:0006936 muscle contraction;GO:0014850 response to muscle activity;GO:0035994 response to muscle stretch;GO:0061061 muscle structure development;GO:0009629 response to gravity", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q29RW1-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99PS8-1", "uniprot_id": [ { "id": "HRG_RAT", "url": "https://www.uniprot.org/uniprot/Q99PS8", "type": "external" } ], "mass": 59049.0, "length": 525, "protein_name": "Histidine-rich glycoprotein", "gene_name": "Hrgl1; Hrg", "organism": "Rat", "refseq_name": "histidine-rich glycoprotein like 1 precursor", "refseq_ac": [ { "id": "NP_001316829", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001316829", "type": "external" } ], "gene_names_uniprotkb": "Hrgl1; Hrg; Hrg l1; Hrg1; Hrgl1; LOC681544", "gene_names_refseq": "Hrgl1; Hrg; RNHRG2; Usp17l8", "protein_names_uniprotkb": "Histidine-rich glycoprotein; HPRG; HRG1; Histidine-proline-rich glycoprotein; Histidine-rich glycoprotein 1", "protein_names_refseq": "histidine-rich glycoprotein 2; histidine-rich glycoprotein like 1 precursor; histidine-rich glycoprotein-like; ubiquitin specific peptidase 17 like family member 8", "tax_id": 10116, "disease": "thrombosis (Disease Ontology:DOID:0060903); thrombophilia due to HRG deficiency (Disease Ontology:DOID:0111903); pancreatic adenocarcinoma (Disease Ontology:DOID:4074)", "pathway": " (rno:171016); (rno:681544); (R-RNO-114608); (R-RNO-75205); (R-RNO-9855719)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "10849117;22673903", "class_list": "", "function": "Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions. Inhibits rosette formation. Acts as an adapter protein and implicated in regulating many processes such as immune complex and pathogen clearance, cell adhesion, angiogenesis, coagulation and fibrinolysis. Mediates clearance of necrotic cells through enhancing the phagocytosis of necrotic cells in a heparan sulfate-dependent pathway. This process can be regulated by the presence of certain HRG ligands such as heparin and zinc ions. Binds to IgG subclasses of immunoglobins containing kappa and lambda light chains with different affinities regulating their clearance and inhibiting the formation of insoluble immune complexes. Tethers plasminogen to the cell surface. Binds T-cells and alters the cell morphology. Modulates angiogenesis by blocking the CD6-mediated antiangiongenic effect of thrombospondins, THBS1 and THBS2 (By similarity)., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "D3ZJN0;Q99PS7;Q9ESB2", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0005102 signaling receptor binding;GO:0008201 heparin binding;GO:0008270 zinc ion binding;GO:0043395 heparan sulfate proteoglycan binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0009986 cell surface", "go_biological_process": "GO:2000504 positive regulation of blood vessel remodeling;GO:0010543 regulation of platelet activation;GO:0007162 negative regulation of cell adhesion;GO:0008285 negative regulation of cell population proliferation;GO:0032956 regulation of actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q99PS8-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2J4-1", "uniprot_id": [ { "id": "NEXN_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z2J4", "type": "external" } ], "mass": 78393.0, "length": 656, "protein_name": "Nexilin", "gene_name": "Nexn", "organism": "Rat", "refseq_name": "nexilin isoform b", "refseq_ac": [ { "id": "NP_631976", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_631976", "type": "external" } ], "gene_names_uniprotkb": "Nexn", "gene_names_refseq": "Nexn", "protein_names_uniprotkb": "Nexilin", "protein_names_refseq": "nexilin isoform b", "tax_id": 10116, "disease": "hypertrophic cardiomyopathy 20 (Disease Ontology:DOID:0110326); dilated cardiomyopathy 1CC (Disease Ontology:DOID:0110424)", "pathway": " (rno:246172)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "19881492;22673903;23383252;25062485;9832551", "class_list": "", "function": "Hepatocyte growth factor upregulates nexilin gene expression in cardiomyocytes via JNK pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity., [UniProtKB]; Nexilin, a cardiomyopathy-associated F-actin binding protein, binds and regulates IRS1 signaling in skeletal muscle cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9Z2J3", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0008307 structural constituent of muscle;GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0005925 focal adhesion;GO:0015629 actin cytoskeleton;GO:0030424 axon", "go_biological_process": "GO:0009617 response to bacterium;GO:0030334 regulation of cell migration;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0051493 regulation of cytoskeleton organization;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9Z2J4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35826-1", "uniprot_id": [ { "id": "GLCNE_RAT", "url": "https://www.uniprot.org/uniprot/O35826", "type": "external" } ], "mass": 79227.0, "length": 722, "protein_name": "Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase", "gene_name": "Gne", "organism": "Rat", "refseq_name": "bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase", "refseq_ac": [ { "id": "NP_446217", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446217", "type": "external" } ], "gene_names_uniprotkb": "Gne; Glcne", "gene_names_refseq": "Gne; Uae1", "protein_names_uniprotkb": "Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase; ManAc kinase; UDP-GlcNAc-2-epimerase/ManAc kinase; UDP-GlcNAc-2-epimerase; Uridine diphosphate-N-acetylglucosamine-2-epimerase; rEpi", "protein_names_refseq": "UDP-GlcNAc-2-epimerase/ManAc kinase; UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase; bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase", "tax_id": 10116, "disease": "GNE myopathy (Disease Ontology:DOID:0080718); thrombocytopenia (Disease Ontology:DOID:1588); sialuria (Disease Ontology:DOID:3659)", "pathway": " (rno:114711); (R-RNO-4085001)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10103025;10334995;10497249;17118363;17448495;18628673;21873062;27037841;33608771;9305887;9305888", "class_list": "", "function": "Analysis of oligomeric states of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase by biophysical methods, [RefSeq, PubMed]; Bifunctional enzyme that possesses both UDP-N-acetylglucosamine 2-epimerase and N-acetylmannosamine kinase activities, and serves as the initiator of the biosynthetic pathway leading to the production of N-acetylneuraminic acid (NeuAc), a critical precursor in the synthesis of sialic acids. By catalyzing this pivotal and rate-limiting step in sialic acid biosynthesis, this enzyme assumes a pivotal role in governing the regulation of cell surface sialylation (PubMed:10497249, PubMed:9305887, PubMed:9305888). Sialic acids represent a category of negatively charged sugars that reside on the surface of cells as terminal components of glycoconjugates and mediate important functions in various cellular processes, including cell adhesion, signal transduction, and cellular recognition (PubMed:10334995)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Data show that overexpression of GNE induces neurite outgrowth in PC12 cells, but does not lead to an increased biosynthesis of sialic acid., [RefSeq, PubMed]; M712T mutation of GNE gene does not affect GNE oligomerization but affects the solubility and posttranslational modification of the GNE protein., [RefSeq, PubMed]; The collapsin response mediator protein 1 and the promyelocytic leukemia zinc finger protein interact with UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE)., [RefSeq, PubMed]; Variations in the mRNA expression level of UDP-GlcNAc epimerase/ManNAc kinase and neuraminidase 1 genes in organs of type 2 diabetic animals., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.60", "type": "external" }, { "id": "3.2.1.183", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.183", "type": "external" } ], "go_molecular_function": "GO:0008761 UDP-N-acetylglucosamine 2-epimerase activity;GO:0009384 N-acylmannosamine kinase activity;GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006045 N-acetylglucosamine biosynthetic process;GO:0006054 N-acetylneuraminate metabolic process;GO:0006055 CMP-N-acetylneuraminate biosynthetic process;GO:0046380 N-acetylneuraminate biosynthetic process;GO:0006047 UDP-N-acetylglucosamine metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "O35826-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11915-1", "uniprot_id": [ { "id": "SCP2_RAT", "url": "https://www.uniprot.org/uniprot/P11915", "type": "external" } ], "mass": 58813.0, "length": 547, "protein_name": "Sterol carrier protein 2", "gene_name": "Podn; Scp2", "organism": "Rat", "refseq_name": "sterol carrier protein 2", "refseq_ac": [ { "id": "NP_612517", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612517", "type": "external" } ], "gene_names_uniprotkb": "Podn; Scp2; Podn; Scp-2", "gene_names_refseq": "NSLIPTR; SCPx; Scp2", "protein_names_uniprotkb": "Sterol carrier protein 2; 2.3.1.155; 2.3.1.16; 2.3.1.176; Acetyl-CoA C-myristoyltransferase; NSL-TP; Non-specific lipid-transfer protein; Propanoyl-CoA C-acyltransferase; SCP-2/3-oxoacyl-CoA thiolase; SCP-2/thiolase; SCP-2; SCP-X; SCP-chi; Sterol carrier protein X", "protein_names_refseq": "NSL-TP; SCP-2/3-oxoacyl-CoA thiolase; SCP-2/thiolase; SCP-2; SCP-X; SCP-chi; Sterol carrier protein 2, liver; acetyl-CoA C-myristoyltransferase; non-specific lipid-transfer protein; propanoyl-CoA C-acyltransferase; sterol carrier protein 2; sterol carrier protein X; straight-chain acyl-CoA oxidase", "tax_id": 10116, "disease": "retinitis pigmentosa (Disease Ontology:DOID:10584); Parkinson's disease (Disease Ontology:DOID:14330); auditory system disease (Disease Ontology:DOID:2742); optic atrophy (Disease Ontology:DOID:5723); Zellweger syndrome (Disease Ontology:DOID:905); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:102552895); (rno:25541); (R-RNO-193368); (R-RNO-2046106); (R-RNO-389887); (R-RNO-9033241)", "pathway_count": 6, "publication_count": 14, "publication_id_list": "10706581;1915369;1985920;2034675;22673903;2334427;2340090;27863214;3115977;3395344;8063752;9245689;9325339;9553048", "class_list": "", "function": "Mediates the transfer of all common phospholipids, cholesterol and gangliosides from the endoplasmic reticulum to the plasma membrane. May play a role in regulating steroidogenesis (By similarity). Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol (PubMed:8063752). Also binds fatty acids and fatty acyl Coenzyme A (CoA) such as phytanoyl-CoA. Involved in the regulation phospholipid synthesis in endoplasmic reticulum enhancing the incorporation of exogenous fatty acid into glycerides. Seems to stimulate the rate-limiting step in phosphatidic acid formation mediated by GPAT3 (By similarity) (PubMed:9553048). Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs (PubMed:9553048)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Plays a crucial role in the peroxisomal oxidation of branched-chain fatty acids (PubMed:8063752, PubMed:9325339). Catalyzes the last step of the peroxisomal beta-oxidation of branched chain fatty acids and the side chain of the bile acid intermediates di- and trihydroxycoprostanic acids (DHCA and THCA) (PubMed:8063752, PubMed:9325339). Also active with medium and long straight chain 3-oxoacyl-CoAs (PubMed:10706581, PubMed:9325339). Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol and transfers phosphatidylcholine and 7-dehydrocholesterol between membrances, in vitro (PubMed:8063752). Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs (PubMed:9553048)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Plays a crucial role in the peroxisomal oxidation of branched-chain fatty acids. Catalyzes the last step of the peroxisomal beta-oxidation of branched chain fatty acids and the side chain of the bile acid intermediates di- and trihydroxycoprostanic acids (DHCA and THCA). Also active with medium and long straight chain 3-oxoacyl-CoAs. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol and transfers phosphatidylcholine and 7-dehydrocholesterol between membrances, in vitro. Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs., [UniProtKB, UniProtKB, UniProtKB]; That type II natural killer T cells reactive with autologous SCP2 are implicated in vascular inflammation in the rat model., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q63383;Q642G0", "ec_number_list": [ { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "1.2.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "1.4.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" }, { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "5.1.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "4.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.9", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" } ], "go_molecular_function": "GO:0033814 propanoyl-CoA C-acyltransferase activity;GO:0050632 propionyl-CoA C2-trimethyltridecanoyltransferase activity;GO:0070538 oleic acid binding;GO:0005102 signaling receptor binding;GO:0005504 fatty acid binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005782 peroxisomal matrix;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0032385 positive regulation of intracellular cholesterol transport;GO:0032959 inositol trisphosphate biosynthetic process;GO:0045940 positive regulation of steroid metabolic process;GO:1901373 lipid hydroperoxide transport;GO:0071926 endocannabinoid signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P11915-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4GTP4-1", "uniprot_id": [ { "id": "ELK1_RAT", "url": "https://www.uniprot.org/uniprot/A4GTP4", "type": "external" } ], "mass": 45272.0, "length": 427, "protein_name": "ETS domain-containing protein Elk-1", "gene_name": "Elk1", "organism": "Rat", "refseq_name": "ETS domain-containing protein Elk-1", "refseq_ac": [ { "id": "NP_001101529", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101529", "type": "external" } ], "gene_names_uniprotkb": "Elk1", "gene_names_refseq": "Elk1", "protein_names_uniprotkb": "ETS domain-containing protein Elk-1", "protein_names_refseq": "ELK1, ETS transcription factor; ELK1, member of ETS oncogene family; ETS domain-containing protein Elk-1", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); Lewy body dementia (Disease Ontology:DOID:12217); Huntington's disease (Disease Ontology:DOID:12858); anxiety disorder (Disease Ontology:DOID:2030); transient cerebral ischemia (Disease Ontology:DOID:224); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:314436)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17156131;24075908;30053446;38649840", "class_list": "", "function": "Elk1 enhances inflammatory cell infiltration and exacerbates acute lung injury/acute respiratory distress syndrome by suppressing Fcgr2b transcription. Publication Status: Online-Only, [RefSeq, PubMed]; Elk1 suppression protects cortical neurons against oxygen-glucose deprivation injury. Erratum:[Exp Cell Res. 2018 Nov 1;372(1):83. doi: 10.1016/j.yexcr.2018.09.007. PMID: 30266209], [RefSeq, PubMed]; Insulin activates prolactin gene transcription by activating Elk-1 that recruits the NuA4 complex to the promoter., [RefSeq, PubMed]; This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. Multiple isoforms are produced from this gene by the use of alternative translational start codons. [provided by RefSeq, Mar 2012]., [RefSeq]; Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2 (By similarity) (PubMed:17156131). Induces target gene transcription upon JNK and MAPK-signaling pathways stimulation (PubMed:17156131)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0003690 double-stranded DNA binding;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0030425 dendrite;GO:0031966 mitochondrial membrane;GO:0043025 neuronal cell body", "go_biological_process": "GO:0001889 liver development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0045471 response to ethanol", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A4GTP4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2GV22-1", "uniprot_id": [ { "id": "PTSS2_RAT", "url": "https://www.uniprot.org/uniprot/B2GV22", "type": "external" } ], "mass": 54722.0, "length": 471, "protein_name": "Phosphatidylserine synthase 2", "gene_name": "Ptdss2", "organism": "Rat", "refseq_name": "phosphatidylserine synthase 2", "refseq_ac": [ { "id": "NP_001099786", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099786", "type": "external" } ], "gene_names_uniprotkb": "Ptdss2", "gene_names_refseq": "PSS-2; Ptdss2", "protein_names_uniprotkb": "Phosphatidylserine synthase 2; 2.7.8.29; PSS-2; PtdSer synthase 2; Serine-exchange enzyme II", "protein_names_refseq": "phosphatidylserine synthase 2; ptdSer synthase 2; serine-exchange enzyme II", "tax_id": 10116, "disease": "", "pathway": " (rno:293620); (R-RNO-1483101)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine., [UniProtKB, UniProtKB]; Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (By similarity). Catalyzes the conversion of phosphatatidylethanolamine and does not act on phosphatidylcholine (By similarity). Can utilize both phosphatidylethanolamine (PE) plasmalogen and diacyl PE as substrate and the latter is six times better utilized, indicating the importance of an ester linkage at the sn-1 position (By similarity). Although it shows no sn-1 fatty acyl preference, exhibits significant preference towards docosahexaenoic acid (22:6n-3) compared with 18:1 or 20:4 at the sn-2 position (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.8.29", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.8.29", "type": "external" } ], "go_molecular_function": "GO:0003882 CDP-diacylglycerol-serine O-phosphatidyltransferase activity;GO:0106245 L-serine-phosphatidylethanolamine phosphatidyltransferase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006659 phosphatidylserine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B2GV22-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZAA9-1", "uniprot_id": [ { "id": "MPP2_RAT", "url": "https://www.uniprot.org/uniprot/D3ZAA9", "type": "external" } ], "mass": 61565.0, "length": 552, "protein_name": "MAGUK p55 subfamily member 2", "gene_name": "Mpp2", "organism": "Rat", "refseq_name": "MAGUK p55 subfamily member 2", "refseq_ac": [ { "id": "NP_445965", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445965", "type": "external" } ], "gene_names_uniprotkb": "Mpp2; rCG_34691", "gene_names_refseq": "Dlg2; Mpp2", "protein_names_uniprotkb": "MAGUK p55 subfamily member 2; Protein MPP2", "protein_names_refseq": "MAGUK p55 subfamily member 2; membrane palmitoylated protein 2; membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)", "tax_id": 10116, "disease": "", "pathway": " (rno:85275)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22673903;27756895;35075790", "class_list": "", "function": "Behavioural and molecular characterisation of the Dlg2 haploinsufficiency rat model of genetic risk for psychiatric disorder., [RefSeq, PubMed]; Postsynaptic MAGUK scaffold protein that links CADM1 cell adhesion molecules to core components of the postsynaptic density (PubMed:27756895). In CA1 pyramidal neurons, required for synaptic KCNN2-containing channel function and long-term potentiation expression (By similarity). Seems to negatively regulate SRC function in epithelial cells (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Proteins. Our results highlight a previously unexplored role for MPP2 at postsynaptic sites as a scaffold that links SynCAM1 cell adhesion molecules to core proteins of the postsynaptic density. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3V8T8", "ec_number_list": [], "go_molecular_function": "GO:0044325 transmembrane transporter binding;GO:0030165 PDZ domain binding;GO:0098919 structural constituent of postsynaptic density", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0014069 postsynaptic density", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0060079 excitatory postsynaptic potential;GO:0060291 long-term synaptic potentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D3ZAA9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZGX1-1", "uniprot_id": [ { "id": "NEXMI_RAT", "url": "https://www.uniprot.org/uniprot/D3ZGX1", "type": "external" } ], "mass": 166662.0, "length": 1517, "protein_name": "Neurite extension and migration factor", "gene_name": "Nexmif", "organism": "Rat", "refseq_name": "neurite extension and migration factor", "refseq_ac": [ { "id": "NP_001300744", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001300744", "type": "external" } ], "gene_names_uniprotkb": "Nexmif", "gene_names_refseq": "KIAA2022; KIDLIA; Nexmif; RGD1561931; Xpn", "protein_names_uniprotkb": "Neurite extension and migration factor; KIAA2022 protein associated with intellectual disability, language impairment and autistic behavior homolog; KIDLIA; XLMR protein related to neurite extension; Xpn", "protein_names_refseq": "XLMR protein related to neurite extension; neurite extension and migration factor", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); non-syndromic X-linked intellectual disability 98 (Disease Ontology:DOID:0112044)", "pathway": " (rno:302396)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "22531377;23615299;24071057;27822498", "class_list": "", "function": "Involved in neurite outgrowth by regulating cell-cell adhesion via the N-cadherin signaling pathway (PubMed:22531377, PubMed:23615299, PubMed:24071057, PubMed:27822498). May act by regulating expression of protein-coding genes, such as N-cadherins and integrin beta-1 (ITGB1) (PubMed:24071057, PubMed:27822498)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Knockdown of KIAA2022/KIDLIA leads to altered neuron migration and a reduction in dendritic growth and disorganized apical dendrite projections in layer II/III cortical neurons. In cultured neurons loss of KIDLIA expression also leads to suppression of dendritic growth and branching. KIDLIA suppression leads to an increase in cell-surface N-cadherin and an elevated association of N-cadherin with delta-catenin. Publication Status: Online-Only, [RefSeq, PubMed]; Result showed that siRNA-mediated KIAA2022 knockdown resulted in marked impairment in neurite outgrowth including both the dendrites and the axons, suggesting a major role for KIAA2022 in neuron development and brain function., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007399 nervous system development;GO:0001953 negative regulation of cell-matrix adhesion;GO:0033629 negative regulation of cell adhesion mediated by integrin;GO:2001223 negative regulation of neuron migration", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "D3ZGX1-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97685-1", "uniprot_id": [ { "id": "NFASC_RAT", "url": "https://www.uniprot.org/uniprot/P97685", "type": "external" } ], "mass": 138004.0, "length": 1240, "protein_name": "Neurofascin", "gene_name": "Nfasc", "organism": "Rat", "refseq_name": "neurofascin isoform 1 precursor", "refseq_ac": [ { "id": "NP_001153786", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153786", "type": "external" } ], "gene_names_uniprotkb": "Nfasc", "gene_names_refseq": "NF; Nfasc", "protein_names_uniprotkb": "Neurofascin", "protein_names_refseq": "neurofascin isoform 1 precursor", "tax_id": 10116, "disease": "MASA syndrome (Disease Ontology:DOID:0060246); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (rno:116690); (R-RNO-447043); (R-RNO-6798695)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10.1039/D0MO00044B;10931875;11470829;16039564;22673903;24090084;29404957;34106099;38843836;8947556;9562181", "class_list": "", "function": "Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions. Isoform 2/isoform 3 may be responsible for mediating and signaling axon-glial interaction during the early stages of myelination., [UniProtKB, PubMed, PubMed, PubMed]; The knock down of neurofascin in the basolateral amygdala prevented a priming-induced impairment on long-term potentiation maintenance in the dentate gyrus., [RefSeq, PubMed]; This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.[provided by RefSeq, May 2009]., [RefSeq]", "predicted_glycosites": 9, "predicted_n_glycosites": 7, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 2, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "P97684;Q91Z60", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0098632 cell-cell adhesion mediator activity;GO:0086080 protein binding involved in heterotypic cell-cell adhesion", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0033010 paranodal junction;GO:0097454 Schwann cell microvillus", "go_biological_process": "GO:0050808 synapse organization;GO:0072659 protein localization to plasma membrane;GO:0042552 myelination;GO:0098609 cell-cell adhesion;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P97685-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4AD53-1", "uniprot_id": [ { "id": "KCNG1_RAT", "url": "https://www.uniprot.org/uniprot/D4AD53", "type": "external" } ], "mass": 58027.0, "length": 514, "protein_name": "Voltage-gated potassium channel regulatory subunit KCNG1", "gene_name": "Kcng1", "organism": "Rat", "refseq_name": "voltage-gated potassium channel regulatory subunit KCNG1 isoform 1", "refseq_ac": [ { "id": "NP_001100015", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100015", "type": "external" } ], "gene_names_uniprotkb": "Kcng1", "gene_names_refseq": "Kcng1; Kh2; Kv6.1", "protein_names_uniprotkb": "Voltage-gated potassium channel regulatory subunit KCNG1; Potassium voltage-gated channel subfamily G member 1; Voltage-gated potassium channel subunit Kv6.1", "protein_names_refseq": "potassium channel, voltage-gated modifier subfamily G, member 1; potassium voltage-gated channel, subfamily G, member 1; voltage-gated potassium channel regulatory subunit KCNG1 isoform 1; voltage-gated potassium channel regulatory subunit KCNG1; voltage-gated potassium channel subunit Kv6.1", "tax_id": 10116, "disease": "", "pathway": " (rno:296395); (R-RNO-1296072)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "8980147;9305895;9696692", "class_list": "", "function": "Regulatory alpha-subunit of the voltage-gated potassium (Kv) channel which, when coassembled with KCNB1 or KCNB2, can modulate their expression and their gating kinetics by acting on deactivation upon repolarization and inactivation during maintained depolarization (PubMed:8980147, PubMed:9305895, PubMed:9696692). Potassium channel subunit that does not form functional channels by itself (PubMed:8980147, PubMed:9305895)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0016020 membrane;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0051260 protein homooligomerization;GO:0001508 action potential;GO:0006813 potassium ion transport;GO:0043266 regulation of potassium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D4AD53-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LQ48-1", "uniprot_id": [ { "id": "HNRPL_RAT", "url": "https://www.uniprot.org/uniprot/F1LQ48", "type": "external" } ], "mass": 67903.0, "length": 623, "protein_name": "Heterogeneous nuclear ribonucleoprotein L", "gene_name": "Hnrnpl", "organism": "Rat", "refseq_name": "heterogeneous nuclear ribonucleoprotein L isoform a", "refseq_ac": [ { "id": "NP_001128232", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001128232", "type": "external" } ], "gene_names_uniprotkb": "Hnrnpl; Fblim1", "gene_names_refseq": "Hnrnpl; Hnrpl; hnrnp-L", "protein_names_uniprotkb": "Heterogeneous nuclear ribonucleoprotein L; hnRNP L", "protein_names_refseq": "heterogeneous nuclear ribonucleoprotein L isoform a; heterogenous nuclear ribonucleoprotein L", "tax_id": 10116, "disease": "Sertoli cell-only syndrome (Disease Ontology:DOID:0050457); brain cancer (Disease Ontology:DOID:1319); lung cancer (Disease Ontology:DOID:1324); systemic scleroderma (Disease Ontology:DOID:418); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:80846); (R-RNO-72163); (R-RNO-72203); (R-RNO-9770562)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "18161049;26051023", "class_list": "", "function": "Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPK and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (By similarity). Regulates alternative splicing of a core group of genes involved in neuronal differentiation, likely by mediating H3K36me3-coupled transcription elongation and co-transcriptional RNA processing via interaction with CHD8., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1LPP9;Q5U1Y5", "ec_number_list": [], "go_molecular_function": "GO:0097157 pre-mRNA intronic binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0000976 transcription cis-regulatory region binding;GO:0003730 mRNA 3'-UTR binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005925 focal adhesion;GO:0030054 cell junction", "go_biological_process": "GO:0033623 regulation of integrin activation;GO:0006397 mRNA processing;GO:0045892 negative regulation of DNA-templated transcription;GO:0098609 cell-cell adhesion;GO:0007623 circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1LQ48-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21807-1", "uniprot_id": [ { "id": "PERI_RAT", "url": "https://www.uniprot.org/uniprot/P21807", "type": "external" } ], "mass": 53550.0, "length": 468, "protein_name": "Peripherin", "gene_name": "Prph", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Prph; Prph1", "gene_names_refseq": "", "protein_names_uniprotkb": "Peripherin", "protein_names_refseq": "", "tax_id": 10116, "disease": "amyotrophic lateral sclerosis type 1 (Disease Ontology:DOID:0060193)", "pathway": " (rno:24688)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "17268851;17569669;19913522;2126481;22673903;2585054;2624740;3272173;3339087;3418352;38843836;7530776;8575457;9388258;9453548", "class_list": "", "function": "Class-III neuronal intermediate filament protein (PubMed:2624740, PubMed:3339087). My form an independent structural network without the involvement of other neurofilaments or may cooperate with the neuronal intermediate filament proteins NEFL, NEFH, NEFM and INA to form a filamentous network (By similarity). Assembly of the neuronal intermediate filaments may be regulated by RAB7A (By similarity). Plays a role in the development of unmyelinated sensory neurons (By similarity). May be involved in axon elongation and axon regeneration after injury (PubMed:2585054, PubMed:7530776). Inhibits neurite extension in type II spiral ganglion neurons in the cochlea (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0044877 protein-containing complex binding;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0043025 neuronal cell body;GO:0043195 terminal bouton;GO:0043204 perikaryon", "go_biological_process": "GO:0045109 intermediate filament organization;GO:0045104 intermediate filament cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P21807-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20069-1", "uniprot_id": [ { "id": "MPPA_RAT", "url": "https://www.uniprot.org/uniprot/P20069", "type": "external" } ], "mass": 58608.0, "length": 524, "protein_name": "Mitochondrial-processing peptidase subunit alpha", "gene_name": "Pmpca", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pmpca; Mppa", "gene_names_refseq": "", "protein_names_uniprotkb": "Mitochondrial-processing peptidase subunit alpha; Alpha-MPP; Inactive zinc metalloprotease alpha; P-55", "protein_names_refseq": "", "tax_id": 10116, "disease": "autosomal recessive spinocerebellar ataxia 2 (Disease Ontology:DOID:0080061)", "pathway": " (R-RNO-8949664); (R-RNO-9837999)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "2236012", "class_list": "", "function": "Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0017087 mitochondrial processing peptidase complex", "go_biological_process": "GO:0016485 protein processing;GO:0006627 protein processing involved in protein targeting to mitochondrion;GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P20069-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35867-1", "uniprot_id": [ { "id": "NEB1_RAT", "url": "https://www.uniprot.org/uniprot/O35867", "type": "external" } ], "mass": 122735.0, "length": 1095, "protein_name": "Neurabin-1", "gene_name": "Ppp1r9a", "organism": "Rat", "refseq_name": "neurabin-1 isoform 2", "refseq_ac": [ { "id": "NP_445925", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445925", "type": "external" } ], "gene_names_uniprotkb": "Ppp1r9a", "gene_names_refseq": "Neb1; PP1bp175; Ppp1r9a; p180", "protein_names_uniprotkb": "Neurabin-1; Neurabin-I; Neural tissue-specific F-actin-binding protein I; PP1bp175; Protein phosphatase 1 regulatory subunit 9A; p180", "protein_names_refseq": "actin-binding protein neurabin; neurabin-1 isoform 2; neurabin-1; neurabin-I; neural tissue-specific F-actin-binding protein I; protein phosphatase 1, regulatory (inhibitor) subunit 9A", "tax_id": 10116, "disease": "Huntington's disease (Disease Ontology:DOID:12858); transient cerebral ischemia (Disease Ontology:DOID:224); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:84685)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10504266;10514494;10585469;20305656;21094159;22673903;29383693;9362513;9653190", "class_list": "", "function": "Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May be involved in neurite formation. Inhibits protein phosphatase 1-alpha activity. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction., [UniProtKB]; Data show that the PP1:spinophilin holoenzyme is dynamic in solution, which allows for an increased capture radius of spinophilin and is likely important for its biological role., [RefSeq, PubMed]; PP1 bound on spinophilin, a close homolog of neurabin and another major synaptic PP1 anchoring protein, does not play a role in long term depression [LTD] induction, which suggests that neurabin plays a privileged role in nanodomain targeting of PP1 in LTD induction., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0051015 actin filament binding;GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098871 postsynaptic actin cytoskeleton;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0014069 postsynaptic density", "go_biological_process": "GO:0007015 actin filament organization;GO:0010976 positive regulation of neuron projection development;GO:0019722 calcium-mediated signaling;GO:0031175 neuron projection development;GO:0060079 excitatory postsynaptic potential", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O35867-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54701-1", "uniprot_id": [ { "id": "NCKX2_RAT", "url": "https://www.uniprot.org/uniprot/O54701", "type": "external" } ], "mass": 74657.0, "length": 670, "protein_name": "Sodium/potassium/calcium exchanger 2", "gene_name": "Slc24a2", "organism": "Rat", "refseq_name": "sodium/potassium/calcium exchanger 2", "refseq_ac": [ { "id": "NP_113931", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113931", "type": "external" } ], "gene_names_uniprotkb": "Slc24a2; Nckx2", "gene_names_refseq": "Nckx2; Slc24a2", "protein_names_uniprotkb": "Sodium/potassium/calcium exchanger 2; Na(+)/K(+)/Ca(2+)-exchange protein 2; Retinal cone Na-Ca+K exchanger; Solute carrier family 24 member 2", "protein_names_refseq": "Na(+)/K(+)/Ca(2+)-exchange protein 2; potassium-dependent sodium-calcium exchanger; retinal cone Na-Ca+K exchanger; sodium/potassium/calcium exchanger 2; solute carrier family 24 (sodium/potassium/calcium exchanger), member 2", "tax_id": 10116, "disease": "", "pathway": " (rno:84550); (R-RNO-425561)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "12218699;22673903;23431067;32582988;9461611", "class_list": "", "function": "A critical role for miR135a5pmediated regulation of SLC24A2 in neuropathic pain., [RefSeq, PubMed]; Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) (PubMed:9461611). Required for learming and memory by regulating neuronal Ca(2+), which is essential for the development of synaptic plasticity (By similarity)., [UniProtKB, UniProtKB, PubMed]; Preferential expression of plasmalemmal K-dependent Na+/Ca2+ exchangers in neurons versus astrocytes., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O54706", "ec_number_list": [], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0015293 symporter activity;GO:0008273 calcium, potassium:sodium antiporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0098794 postsynapse;GO:0098793 presynapse", "go_biological_process": "GO:0007612 learning;GO:0007613 memory;GO:0006816 calcium ion transport;GO:0006874 intracellular calcium ion homeostasis;GO:0034220 monoatomic ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O54701-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06762-1", "uniprot_id": [ { "id": "HMOX1_RAT", "url": "https://www.uniprot.org/uniprot/P06762", "type": "external" } ], "mass": 33006.0, "length": 289, "protein_name": "Heme oxygenase 1", "gene_name": "Hmox1", "organism": "Rat", "refseq_name": "heme oxygenase 1", "refseq_ac": [ { "id": "NP_036712", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036712", "type": "external" } ], "gene_names_uniprotkb": "Hmox1", "gene_names_refseq": "HEOXG; Heox; Hmox1; Hmox; Ho-1; Ho1; hsp32", "protein_names_uniprotkb": "Heme oxygenase 1; 1.14.14.18; HO-1; HSP32", "protein_names_refseq": "heme oxygenase (decycling) 1; heme oxygenase (decyclizing) 1; heme oxygenase 1", "tax_id": 10116, "disease": "obstructive sleep apnea (Disease Ontology:DOID:0050848); limb ischemia (Disease Ontology:DOID:0050852); stroke (Disease Ontology:DOID:0051061); colitis (Disease Ontology:DOID:0060180); hepatic veno-occlusive disease (Disease Ontology:DOID:0080177); Parkinsonism (Disease Ontology:DOID:0080855); berylliosis (Disease Ontology:DOID:10322); silicosis (Disease Ontology:DOID:10325); Alzheimer's disease (Disease Ontology:DOID:10652); renal hypertension (Disease Ontology:DOID:1073); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); sickle cell anemia (Disease Ontology:DOID:10923); IgA vasculitis (Disease Ontology:DOID:11123); adult respiratory distress syndrome (Disease Ontology:DOID:11394); sciatic neuropathy (Disease Ontology:DOID:11446); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); factor VIII deficiency (Disease Ontology:DOID:12134); primary biliary cholangitis (Disease Ontology:DOID:12236); varicocele (Disease Ontology:DOID:12337); malaria (Disease Ontology:DOID:12365); retinal ischemia (Disease Ontology:DOID:12510); newborn respiratory distress syndrome (Disease Ontology:DOID:12716); Sjogren's syndrome (Disease Ontology:DOID:12894); intracranial vasospasm (Disease Ontology:DOID:13100); Behcet's disease (Disease Ontology:DOID:13241); pulmonary sarcoidosis (Disease Ontology:DOID:13406); hepatic encephalopathy (Disease Ontology:DOID:13413); toxic shock syndrome (Disease Ontology:DOID:14115); cystic fibrosis (Disease Ontology:DOID:1485); acute chest syndrome (Disease Ontology:DOID:1584); pneumothorax (Disease Ontology:DOID:1673); status epilepticus (Disease Ontology:DOID:1824); brain ischemia (Disease Ontology:DOID:2316); hemochromatosis (Disease Ontology:DOID:2352); asthma (Disease Ontology:DOID:2841); adenocarcinoma (Disease Ontology:DOID:299); acute kidney failure (Disease Ontology:DOID:3021); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); coronary artery disease (Disease Ontology:DOID:3393); middle cerebral artery infarction (Disease Ontology:DOID:3525); coronary restenosis (Disease Ontology:DOID:4247); brain edema (Disease Ontology:DOID:4724); esophageal cancer (Disease Ontology:DOID:5041); pulmonary venoocclusive disease (Disease Ontology:DOID:5453); pneumonia (Disease Ontology:DOID:552); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); peptic ulcer disease (Disease Ontology:DOID:750); abdominal aortic aneurysm (Disease Ontology:DOID:7693); hyperthyroidism (Disease Ontology:DOID:7998); ileus (Disease Ontology:DOID:8440); lung disease (Disease Ontology:DOID:850); hepatopulmonary syndrome (Disease Ontology:DOID:900); acute myeloid leukemia (Disease Ontology:DOID:9119); visceral leishmaniasis (Disease Ontology:DOID:9146); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (rno:24451); (R-RNO-189483); (R-RNO-917937); (R-RNO-9609523); (R-RNO-9707564); (R-RNO-9707587)", "pathway_count": 6, "publication_count": 12, "publication_id_list": "10760513;1575508;1935972;22673903;29393594;3032976;38573338;38583746;3865203;39075530;39293832;39444099", "class_list": "", "function": "Acupoint Autohemotherapy Alleviates Airway Inflammation in Asthmatic Rats via Upregulating Expression of Hemeoxygenase-1., [RefSeq, PubMed]; Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron (PubMed:1575508, PubMed:1935972, PubMed:3865203). Affords protection against programmed cell death and this cytoprotective effect relies on its ability to catabolize free heme and prevent it from sensitizing cells to undergo apoptosis (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; LncRNA HMOX1 alleviates renal ischemia-reperfusion-induced ferroptotic injury via the miR-3587/HMOX1 axis., [RefSeq, PubMed]; MiR-340-3p-modified bone marrow mesenchymal stem cell-derived exosomes inhibit ferroptosis through METTL3-mediated m[6]A modification of HMOX1 to promote recovery of injured rat uterus. Erratum:[Stem Cell Res Ther. 2024 Oct 10;15(1):357. doi: 10.1186/s13287-024-03985-w. PMID: 39390524] Publication Status: Online-Only, [RefSeq, PubMed]; The Bach1/HO-1 pathway regulates oxidative stress and contributes to ferroptosis in doxorubicin-induced cardiomyopathy in H9c2 cells and mice., [RefSeq, PubMed]; The Role of Heme Oxygenase 1 in Rheumatoid Arthritis and IL-1 Induced Inflammatory Cell Model., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 60, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5BK87", "ec_number_list": [ { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "1.2.1.94", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.94", "type": "external" } ], "go_molecular_function": "GO:0004630 phospholipase D activity;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:1904681 response to 3-methylcholanthrene;GO:0031670 cellular response to nutrient;GO:1904550 response to arachidonate;GO:0002246 wound healing involved in inflammatory response;GO:1904036 negative regulation of epithelial cell apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P06762-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31423-1", "uniprot_id": [ { "id": "GRM4_RAT", "url": "https://www.uniprot.org/uniprot/P31423", "type": "external" } ], "mass": 101819.0, "length": 912, "protein_name": "Metabotropic glutamate receptor 4", "gene_name": "Grm4", "organism": "Rat", "refseq_name": "metabotropic glutamate receptor 4 precursor", "refseq_ac": [ { "id": "NP_073157", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073157", "type": "external" } ], "gene_names_uniprotkb": "Grm4; Gprc1d; Mglur4", "gene_names_refseq": "Grm4; mGluR4", "protein_names_uniprotkb": "Metabotropic glutamate receptor 4; mGluR4", "protein_names_refseq": "glutamate receptor, metabotropic 4; metabotropic glutamate receptor 4 precursor; metabotropic glutamate receptor 4", "tax_id": 10116, "disease": "Sertoli cell-only syndrome (Disease Ontology:DOID:0050457); syndromic X-linked intellectual disability (Disease Ontology:DOID:0060309); childhood medulloblastoma (Disease Ontology:DOID:3869); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:24417); (R-RNO-418594); (R-RNO-420499)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "11122333;1309649;28487067;28661401;28829739;32052426;34244459;38843836;8338667", "class_list": "", "function": "Activation of metabotropic glutamate receptor 4 regulates proliferation and neural differentiation in neural stem/progenitor cells of the rat subventricular zone and increases phosphatase and tensin homolog protein expression., [RefSeq, PubMed]; Although assumed to form exclusive homodimers, 16 possible heterodimeric mGluRs have been proposed but their existence in native cells remains elusive. Study identified mGlu2-4 specific pharmacological fingerprints that were also observed in a neuronal cell line and in lateral perforant path terminals naturally expressing mGlu2 and mGlu4. Results show the existence of mGlu2-4 heterodimers in native cells. Publication Status: Online-Only, [RefSeq, PubMed]; G protein-coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity., [UniProtKB]; Regulation and functional consequences of mGlu4 RNA editing., [RefSeq, PubMed]; This study investigated the role of mGluR4 in modulating two distinct forms of waiting impulsivity and its putative interaction with D2 receptors in modulating motor impulsivity on the five-choice serial reaction time task. The main findings indicate a prominent role of mGluR4 in modulating motor, and to some extent choice, impulsivity as well as aspects of visual attention., [RefSeq, PubMed]; Whereas both glutamate metabotropic receptor 2 and glutamate metabotropic receptor 4 couple to G proteins, G protein activation is mediated by mGlu4 heptahelical domain (HD) exclusively in glutamate metabotropic receptor 2-4 heterodimers. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001640 adenylate cyclase inhibiting G protein-coupled glutamate receptor activity;GO:0004930 G protein-coupled receptor activity;GO:0005516 calmodulin binding;GO:0048306 calcium-dependent protein binding;GO:0008066 glutamate receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0043195 terminal bouton;GO:0043198 dendritic shaft", "go_biological_process": "GO:0007612 learning;GO:0008285 negative regulation of cell population proliferation;GO:0031175 neuron projection development;GO:0043066 negative regulation of apoptotic process;GO:0043410 positive regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P31423-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49897-1", "uniprot_id": [ { "id": "IOD3_RAT", "url": "https://www.uniprot.org/uniprot/P49897", "type": "external" } ], "mass": 34096.0, "length": 304, "protein_name": "Thyroxine 5-deiodinase", "gene_name": "Dio3", "organism": "Rat", "refseq_name": "thyroxine 5-deiodinase", "refseq_ac": [ { "id": "NP_058906", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058906", "type": "external" } ], "gene_names_uniprotkb": "Dio3; Itdi3; Txdi3", "gene_names_refseq": "5DIII; DIOIII; Dio3", "protein_names_uniprotkb": "Thyroxine 5-deiodinase; 1.21.99.3; 5DIII; DIOIII; Type 3 DI; Type III iodothyronine deiodinase", "protein_names_refseq": "deiodinase, iodothyronine, type 3; deiodinase, iodothyronine, type III; thyroxine 5-deiodinase; type 3 DI; type III iodothyronine deiodinase; type-III 5'-deiodinase", "tax_id": 10116, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (rno:29475); (R-RNO-350864)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "12959985;17510246;33746903;39238408;7622463", "class_list": "", "function": "Adaptive Thermogenesis Driving Catch-Up Fat Is Associated With Increased Muscle Type 3 and Decreased Hepatic Type 1 Iodothyronine Deiodinase Activities: A Functional and Proteomic Study. Publication Status: Online-Only, [RefSeq, PubMed]; Genomic imprinting and gene expression at the Dlk1/Dio3 imprinted domain may play a role in the regulation of adipocyte proliferation and differentiation, [RefSeq, PubMed]; Induction of D3 activity begins immediately after implantation and increases markedly over next 72 hours. In spontaneously cycling female rats, both D2 and D3 were observed to be 3- to 8-fold higher in proestrus, compared with diestrus., [RefSeq, PubMed]; Plays a crucial role in the metabolism of thyroid hormones (TH) and has specific roles in TH activation and inactivation by deiodination. Catalyzes the deiodination of L-thyroxine (T4) to 3,3',5'-triiodothyronine (rT3), 3,5-diiodothyronine (3,5-T2) to 3-monoiodothyronine (3-T1), rT3 to 3',5'-diiodothyronine (3',5'-T2) and 3,3'-diiodothyronine (3,3'-T2) to 3'-monoiodothyronine (3'-T1) via inner-ring deiodination (IRD) (By similarity). Catalyzes the deiodination of 3,5,3'-triiodothyronine (T3) to 3,3'-diiodothyronine (3,3'-T2) via IRD (PubMed:7622463). Catalyzes the deiodination of 3-T1 to L-thyronine (T0) via outer-ring deiodination (ORD) (By similarity). Catalyzes the tyrosyl ring deiodinations of T4AM (3,3',5,5'-tetraiodothyronamine), rT3AM (3,3',5'-triiodothyronamine), T3AM (3,5,3'-triiodothyronamine), 3,5-T2AM (3,5-diiodothyronamine), 3,3'-T2AM (3,3'-diiodothyronamine) and 3-T1AM (3-iodothyronamine) (By similarity)., [UniProtKB, PubMed, UniProtKB]; This is an intronless, imprinted gene that is preferentially expressed from the paternal allele. The encoded protein belongs to the iodothyronine deiodinase family, and catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5' triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. It is highly expressed in placenta, fetal and neonatal tissues, and thought to prevent premature exposure of developing fetal tissues to adult levels of thyroid hormones. It thus plays a critical role in mammalian development by regulating circulating fetal thyroid hormone concentration. This protein is a selenoprotein, containing the rare selenocysteine (Sec) amino acid at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jun 2016]., [RefSeq]; [Inhibition of type 3 deiodinase expression can improve mitochondrial function in skeletal muscle of sepsis by up-regulating peroxisome proliferator-activated receptor-gamma coactivator-1alpha]., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.21.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.21.99.3", "type": "external" }, { "id": "1.21.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.21.99.4", "type": "external" } ], "go_molecular_function": "GO:0033798 thyroxine 5-deiodinase activity;GO:0004800 thyroxine 5'-deiodinase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0042404 thyroid hormone catabolic process;GO:0001666 response to hypoxia;GO:0006915 apoptotic process;GO:0042446 hormone biosynthetic process;GO:0040018 positive regulation of multicellular organism growth", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P49897-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V893-1", "uniprot_id": [ { "id": "GPAM1_RAT", "url": "https://www.uniprot.org/uniprot/Q4V893", "type": "external" } ], "mass": 39174.0, "length": 348, "protein_name": "GPALPP motifs-containing protein 1", "gene_name": "Gpalpp1", "organism": "Rat", "refseq_name": "GPALPP motifs-containing protein 1", "refseq_ac": [ { "id": "NP_001020046", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020046", "type": "external" } ], "gene_names_uniprotkb": "Gpalpp1", "gene_names_refseq": "Gpalpp1; RGD1307254", "protein_names_uniprotkb": "GPALPP motifs-containing protein 1", "protein_names_refseq": "GPALPP motifs-containing protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:298712)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4V893-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5DT37-1", "uniprot_id": [ { "id": "KLRI2_RAT", "url": "https://www.uniprot.org/uniprot/Q5DT37", "type": "external" } ], "mass": 28814.0, "length": 247, "protein_name": "Killer cell lectin-like receptor subfamily I member 2", "gene_name": "Klri2", "organism": "Rat", "refseq_name": "killer cell lectin-like receptor subfamily I member 2", "refseq_ac": [ { "id": "NP_001012666", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012666", "type": "external" } ], "gene_names_uniprotkb": "Klri2", "gene_names_refseq": "Klri2", "protein_names_uniprotkb": "Killer cell lectin-like receptor subfamily I member 2", "protein_names_refseq": "killer cell lectin-like receptor subfamily I member 2", "tax_id": 10116, "disease": "", "pathway": " (rno:503650)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15650876;18713988", "class_list": "", "function": "KLRE1-KLRI2 heterodimer is a functional activating heterodimer in NK cells, [RefSeq, PubMed]; Lectin-like receptor for natural killer (NK) cells. Heterodimer formation with KLRE1 mediates NK cell cytolytic activity., [UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0002228 natural killer cell mediated immunity;GO:0045954 positive regulation of natural killer cell mediated cytotoxicity;GO:0002223 stimulatory C-type lectin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5DT37-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5DT39-1", "uniprot_id": [ { "id": "KLRI1_RAT", "url": "https://www.uniprot.org/uniprot/Q5DT39", "type": "external" } ], "mass": 28175.0, "length": 243, "protein_name": "Killer cell lectin-like receptor subfamily I member 1", "gene_name": "Klri1", "organism": "Rat", "refseq_name": "killer cell lectin-like receptor subfamily I member 1", "refseq_ac": [ { "id": "NP_001012667", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012667", "type": "external" } ], "gene_names_uniprotkb": "Klri1", "gene_names_refseq": "Klri1", "protein_names_uniprotkb": "Killer cell lectin-like receptor subfamily I member 1", "protein_names_refseq": "killer cell lectin-like receptor subfamily I member 1", "tax_id": 10116, "disease": "", "pathway": " (rno:503651)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15650876;18713988", "class_list": "", "function": "KLRE1-KLRI1 heterodimer is a functional inhibitory heterodimer in NK cells, [RefSeq, PubMed]; Lectin-like receptor for natural killer (NK) cells. Heterodimer formation with KLRE1 mediates inhibition of NK cell cytolytic activity., [UniProtKB, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "E9PTP0", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0002228 natural killer cell mediated immunity;GO:0045954 positive regulation of natural killer cell mediated cytotoxicity;GO:0002223 stimulatory C-type lectin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5DT39-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62645-1", "uniprot_id": [ { "id": "NMDE4_RAT", "url": "https://www.uniprot.org/uniprot/Q62645", "type": "external" } ], "mass": 143101.0, "length": 1323, "protein_name": "Glutamate receptor ionotropic, NMDA 2D", "gene_name": "Grin2d", "organism": "Rat", "refseq_name": "glutamate receptor ionotropic, NMDA 2D precursor", "refseq_ac": [ { "id": "NP_073634", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073634", "type": "external" } ], "gene_names_uniprotkb": "Grin2d; GluN2D", "gene_names_refseq": "GluN2D; Grin2d", "protein_names_uniprotkb": "Glutamate receptor ionotropic, NMDA 2D; GluN2D; Glutamate [NMDA] receptor subunit epsilon-4; N-methyl D-aspartate receptor subtype 2D; NMDAR2D; NR2D", "protein_names_refseq": "N-methyl D-aspartate receptor subtype 2D; NMDAR2D; NR2D; glutamate [NMDA] receptor subunit epsilon-4; glutamate receptor ionotropic, NMDA 2D precursor; glutamate receptor ionotropic, NMDA 2D; glutamate receptor, ionotropic, N-methyl D-aspartate 2D; glutamate receptor, ionotropic, NMDA2D", "tax_id": 10116, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); abdominal obesity-metabolic syndrome (Disease Ontology:DOID:0060611); developmental and epileptic encephalopathy 46 (Disease Ontology:DOID:0080456); alcohol use disorder (Disease Ontology:DOID:1574); cancer (Disease Ontology:DOID:162); epilepsy (Disease Ontology:DOID:1826); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:24412); (R-RNO-438066); (R-RNO-5673001); (R-RNO-8849932); (R-RNO-9609736)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "21522138;23625947;30261285;31969570;38277219;38843836;7512349;7569905;8428958;9463421;9647694", "class_list": "", "function": "Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:21522138, PubMed:23625947, PubMed:7512349). Participates in synaptic plasticity for learning and memory formation (By similarity). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:21522138, PubMed:23625947, PubMed:7512349). NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium (By similarity). Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (PubMed:23625947, PubMed:7512349, PubMed:9463421)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, UniProtKB]; Inhibition of GluN2D-Containing NMDA Receptors Protects Dopaminergic Neurons against 6-OHDA-Induced Neurotoxicity via Activating ERK/NRF2/HO-1 Signaling., [RefSeq, PubMed]; Study supports a role for GluN2D-NMDARs in L-DOPA-induced dyskinesia (LID), and they confirm that cell-type and subunit specific modifications of NMDARs underlie the pathophysiology of LID., [RefSeq, PubMed]; UBP791 ((2S*, 3R*)-1-(7-(2-carboxyethyl)phenanthrene-2-carbonyl)piperazine-2, 3-dicarboxylic acid) inhibits GluN2C/2D with 40-fold selectivity over GluN2A-containing receptors, and that a methionine and a lysine residue in the ligand binding pocket are the critical molecular elements for the subtype-specific binding. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 7, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q63381;Q63382;Q63729;Q63730", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0022849 glutamate-gated calcium ion channel activity;GO:0005261 monoatomic cation channel activity;GO:0004970 glutamate-gated receptor activity;GO:0016595 glutamate binding;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0017146 NMDA selective glutamate receptor complex;GO:0008328 ionotropic glutamate receptor complex;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0001964 startle response;GO:0008344 adult locomotory behavior;GO:0035235 ionotropic glutamate receptor signaling pathway;GO:0060079 excitatory postsynaptic potential;GO:2000463 positive regulation of excitatory postsynaptic potential", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q62645-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64289-1", "uniprot_id": [ { "id": "NDF1_RAT", "url": "https://www.uniprot.org/uniprot/Q64289", "type": "external" } ], "mass": 40001.0, "length": 357, "protein_name": "Neurogenic differentiation factor 1", "gene_name": "Neurod1", "organism": "Rat", "refseq_name": "neurogenic differentiation factor 1", "refseq_ac": [ { "id": "NP_062091", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062091", "type": "external" } ], "gene_names_uniprotkb": "Neurod1; Neurod", "gene_names_refseq": "Neurod1", "protein_names_uniprotkb": "Neurogenic differentiation factor 1; BHF-1; Basic helix-loop-helix factor 1; NeuroD1", "protein_names_refseq": "BHF-1; basic helix-loop-helix factor 1; neurogenic differentiation 1; neurogenic differentiation factor 1", "tax_id": 10116, "disease": "type 1 diabetes mellitus 7 (Disease Ontology:DOID:0110746); maturity-onset diabetes of the young type 6 (Disease Ontology:DOID:0111104); glucose intolerance (Disease Ontology:DOID:10603); hypertension (Disease Ontology:DOID:10763); hyperglycemia (Disease Ontology:DOID:4195); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:29458)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10101232;12297313;14741104;19272376;20554861;24338128;25752781;33340723;8660336", "class_list": "", "function": "Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3' (By similarity). Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A (By similarity). Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine (By similarity). Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification (By similarity). Also required for dendrite morphogenesis and maintenance in the cerebellar cortex (PubMed:14741104). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity)., [UniProtKB, UniProtKB, PubMed]; LncRNA SOX2OT Knockdown Alleviates Lipopolysaccharide-Induced Damage of PC12 Cells by Regulating miR-331-3p/Neurod1 Axis., [RefSeq, PubMed]; NeuroD1, an essential regulator of glutamatergic neuronal differentiation, as a new mRNA target interacting with FMRP in co-immunoprecipitation experiments., [RefSeq, PubMed]; The nuclear import of NeuroD1 and E47 is energy-dependent and involves the Ran-mediated pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q569P0", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0046982 protein heterodimerization activity;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006913 nucleocytoplasmic transport;GO:0032024 positive regulation of insulin secretion;GO:0043065 positive regulation of apoptotic process;GO:0045666 positive regulation of neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q64289-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYG7-1", "uniprot_id": [ { "id": "NF2IP_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYG7", "type": "external" } ], "mass": 45430.0, "length": 414, "protein_name": "NFATC2-interacting protein", "gene_name": "Nfatc2ip", "organism": "Rat", "refseq_name": "NFATC2-interacting protein", "refseq_ac": [ { "id": "NP_001007693", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007693", "type": "external" } ], "gene_names_uniprotkb": "Nfatc2ip", "gene_names_refseq": "Nfatc2ip", "protein_names_uniprotkb": "NFATC2-interacting protein; Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein", "protein_names_refseq": "NFATC2-interacting protein; nuclear factor of activated T-cells, cytoplasmic 2-interacting protein; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein", "tax_id": 10116, "disease": "", "pathway": " (rno:308983)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;38894694", "class_list": "", "function": "In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity)., [UniProtKB]; MiR-31-5p suppresses myocardial hypertrophy by targeting Nfatc2ip., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6AYG7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63862-1", "uniprot_id": [ { "id": "MYH11_RAT", "url": "https://www.uniprot.org/uniprot/Q63862", "type": "external" } ], "mass": 152492.0, "length": 1327, "protein_name": "Myosin-11", "gene_name": "Myh11", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Myh11", "gene_names_refseq": "", "protein_names_uniprotkb": "Myosin-11; Myosin heavy chain 11; Myosin heavy chain, smooth muscle isoform; SMMHC", "protein_names_refseq": "", "tax_id": 10116, "disease": "megacystis-microcolon-intestinal hypoperistalsis syndrome (Disease Ontology:DOID:0060610); MYH-9 related disease (Disease Ontology:DOID:0060651); patent ductus arteriosus (Disease Ontology:DOID:13832); thoracic aortic aneurysm (Disease Ontology:DOID:14004); abdominal aortic aneurysm (Disease Ontology:DOID:7693)", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "22673903;2614841;7684561", "class_list": "", "function": "Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9. Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Muscle contraction., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q58GJ0;Q63338;Q63339;Q63861", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0043531 ADP binding;GO:0008307 structural constituent of muscle", "go_cellular_component": "GO:0005859 muscle myosin complex;GO:0098871 postsynaptic actin cytoskeleton;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006939 smooth muscle contraction;GO:0007015 actin filament organization;GO:0051017 actin filament bundle assembly;GO:0031032 actomyosin structure organization;GO:0055013 cardiac muscle cell development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q63862-1", "record_type": "protein", "filter_code": "0000000.0000110.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33273-1", "uniprot_id": [ { "id": "CP255_RAT", "url": "https://www.uniprot.org/uniprot/P33273", "type": "external" } ], "mass": 55991.0, "length": 490, "protein_name": "Cytochrome P450 2C55", "gene_name": "Cyp2c55", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cyp2c55; Cyp2c-55; Cyp2c24; LOC100361492", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytochrome P450 2C55; 1.14.14.1; CYPIIC24; CYPIIC55; Cytochrome P450 2C24; Cytochrome P450-PROS2", "protein_names_refseq": "", "tax_id": 10116, "disease": "invasive aspergillosis (Disease Ontology:DOID:0050073); Keshan disease (Disease Ontology:DOID:0050083); alcohol dependence (Disease Ontology:DOID:0050741); warfarin resistance (Disease Ontology:DOID:0080665); hypertension (Disease Ontology:DOID:10763); sickle cell anemia (Disease Ontology:DOID:10923); urinary bladder cancer (Disease Ontology:DOID:11054); dilated cardiomyopathy (Disease Ontology:DOID:12930); eosinophilic esophagitis (Disease Ontology:DOID:13922); Plasmodium falciparum malaria (Disease Ontology:DOID:14067); breast cancer (Disease Ontology:DOID:1612); tuberculosis (Disease Ontology:DOID:399); hyperglycemia (Disease Ontology:DOID:4195); multiple chemical sensitivity (Disease Ontology:DOID:4661); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); hepatocellular carcinoma (Disease Ontology:DOID:684); peptic ulcer disease (Disease Ontology:DOID:750); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); heroin dependence (Disease Ontology:DOID:9976); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (rno:100361492)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1953735", "class_list": "", "function": "Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics., [UniProtKB, UniProtKB]; Metabolizes arachidonic acid mainly to 19-hydroxyeicosatetraenoic acid (HETE)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 22, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" }, { "id": "1.14.14.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.-", "type": "external" }, { "id": "4.2.1.152", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.152", "type": "external" }, { "id": "1.14.13.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.n7", "type": "external" } ], "go_molecular_function": "GO:0071614 linoleic acid epoxygenase activity;GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0008392 arachidonate epoxygenase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0043651 linoleic acid metabolic process;GO:0019369 arachidonate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P33273-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3MKQ2-1", "uniprot_id": [ { "id": "BEX1_RAT", "url": "https://www.uniprot.org/uniprot/Q3MKQ2", "type": "external" } ], "mass": 15248.0, "length": 128, "protein_name": "Protein BEX1", "gene_name": "Bex1", "organism": "Rat", "refseq_name": "protein BEX1", "refseq_ac": [ { "id": "NP_001032442", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032442", "type": "external" } ], "gene_names_uniprotkb": "Bex1; Bex2", "gene_names_refseq": "Bex1h; Bex1; Bex2; Bex", "protein_names_uniprotkb": "Protein BEX1; Brain-expressed X-linked protein 1 homolog; EG2RVC", "protein_names_refseq": "EG2RVC; brain expressed X-linked 2; brain expressed gene 1; brain-expressed X-linked protein 1 homolog; brain-expressed X-linked protein 2 homolog; protein BEX1; protein BEX2", "tax_id": 10116, "disease": "", "pathway": " (rno:501625)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15033532;15958283;16498402;25612294;29572119", "class_list": "", "function": "Bex family members play important roles in the formation of protein network hubs. Publication Status: Online-Only, [RefSeq, PubMed]; Bex1 may play the neuronal anti-apoptosis role following intracerebral hemorrhage (ICH), implying a novel molecular target for the therapy of ICH., [RefSeq, PubMed]; Signaling adapter molecule involved in p75NTR/NGFR signaling (PubMed:16498402). Plays a role in cell cycle progression and neuronal differentiation (PubMed:16498402). Inhibits neuronal differentiation in response to nerve growth factor (NGF) (PubMed:16498402). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states (PubMed:16498402). In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6XUZ8", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0046872 metal ion binding;GO:0140678 molecular function inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0007165 signal transduction;GO:0045665 negative regulation of neuron differentiation;GO:0042981 regulation of apoptotic process;GO:0031397 negative regulation of protein ubiquitination;GO:0002052 positive regulation of neuroblast proliferation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3MKQ2-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29147-1", "uniprot_id": [ { "id": "BDH_RAT", "url": "https://www.uniprot.org/uniprot/P29147", "type": "external" } ], "mass": 38202.0, "length": 343, "protein_name": "D-beta-hydroxybutyrate dehydrogenase, mitochondrial", "gene_name": "Bdh1", "organism": "Rat", "refseq_name": "D-beta-hydroxybutyrate dehydrogenase, mitochondrial", "refseq_ac": [ { "id": "NP_446447", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446447", "type": "external" } ], "gene_names_uniprotkb": "Bdh1; Bdh", "gene_names_refseq": "Bdh1; Bdh", "protein_names_uniprotkb": "D-beta-hydroxybutyrate dehydrogenase, mitochondrial; 1.1.1.30; 3-hydroxybutyrate dehydrogenase; BDH", "protein_names_refseq": "3-hydroxybutyrate dehydrogenase (heart, mitochondrial); 3-hydroxybutyrate dehydrogenase, type 1; D-beta-hydroxybutyrate dehydrogenase, mitochondrial", "tax_id": 10116, "disease": "chromosome 3q29 microdeletion syndrome (Disease Ontology:DOID:0060419); COVID-19 (Disease Ontology:DOID:0080600); hyperthyroidism (Disease Ontology:DOID:7998)", "pathway": " (rno:117099); (R-RNO-77108); (R-RNO-77111); (R-RNO-9837999)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "1567834;22673903;24098488;38843836;8515054", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5U2Q2", "ec_number_list": [ { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "1.1.1.104", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.104", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "1.1.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.41", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" } ], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0003858 3-hydroxybutyrate dehydrogenase activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0099617 matrix side of mitochondrial inner membrane", "go_biological_process": "GO:0001889 liver development;GO:0007584 response to nutrient;GO:0042594 response to starvation;GO:0045471 response to ethanol;GO:0060612 adipose tissue development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P29147-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CFN2-1", "uniprot_id": [ { "id": "CDC42_RAT", "url": "https://www.uniprot.org/uniprot/Q8CFN2", "type": "external" } ], "mass": 21259.0, "length": 191, "protein_name": "Cell division control protein 42 homolog", "gene_name": "Cdc42", "organism": "Rat", "refseq_name": "cell division control protein 42 homolog", "refseq_ac": [ { "id": "NP_741991", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_741991", "type": "external" } ], "gene_names_uniprotkb": "Cdc42", "gene_names_refseq": "Cdc42", "protein_names_uniprotkb": "Cell division control protein 42 homolog; 3.6.5.2", "protein_names_refseq": "cell division control protein 42 homolog; cell division cycle 42 (GTP binding protein); cell division cycle 42 homolog", "tax_id": 10116, "disease": "cerebral cavernous malformation (Disease Ontology:DOID:0060669); microvillus inclusion disease (Disease Ontology:DOID:0060775); Alzheimer's disease (Disease Ontology:DOID:10652); pancreatic cancer (Disease Ontology:DOID:1793); syndrome (Disease Ontology:DOID:225); bipolar disorder (Disease Ontology:DOID:3312); temporal lobe epilepsy (Disease Ontology:DOID:3328); fibrosarcoma (Disease Ontology:DOID:3355); rhinitis (Disease Ontology:DOID:4483); myelofibrosis (Disease Ontology:DOID:4971); kidney disease (Disease Ontology:DOID:557); cleft palate (Disease Ontology:DOID:674)", "pathway": " (rno:64465); (R-RNO-114604); (R-RNO-182971); (R-RNO-2029482); (R-RNO-389359); (R-RNO-3928662); (R-RNO-418885); (R-RNO-4420097); (R-RNO-525793); (R-RNO-5625970); (R-RNO-5626467); (R-RNO-5627123); (R-RNO-5663213); (R-RNO-5663220); (R-RNO-5687128); (R-RNO-8964616); (R-RNO-9013148); (R-RNO-9013149); (R-RNO-9013404); (R-RNO-9013406); (R-RNO-9013408); (R-RNO-9013420); (R-RNO-9013423); (R-RNO-9013424); (R-RNO-983231); (R-RNO-9958810); (R-RNO-9958825)", "pathway_count": 27, "publication_count": 8, "publication_id_list": "11048641;21423166;25498153;31397884;34634536;34753065;36137969;38386112", "class_list": "", "function": "CDC42 contributes to vascular calcification in chronic kidney disease through a mechanism involving AKT signaling., [RefSeq, PubMed]; Cdc42 Promotes Axonogenesis of Primary Hippocampal Neurons by Inhibiting Glycogen Synthase Kinase-3beta., [RefSeq, PubMed]; Cdc42 activates paracellular transport in polarised submandibular gland cells., [RefSeq, PubMed]; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Spatiotemporal distribution of PKCalpha, Cdc42, and Rac1 before directed cell migration., [RefSeq, PubMed]; The distinct localization of CDC42 isoforms is responsible for their specific functions during migration., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P9Y3;Q71TW5", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "1.3.1.70", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.70", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "1.16.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.1.-", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "1.6.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "5.6.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.3", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding;GO:0034191 apolipoprotein A-I receptor binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0086100 endothelin receptor signaling pathway;GO:0006468 protein phosphorylation;GO:0006897 endocytosis;GO:0006911 phagocytosis, engulfment;GO:0007015 actin filament organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8CFN2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88778-1", "uniprot_id": [ { "id": "BSN_RAT", "url": "https://www.uniprot.org/uniprot/O88778", "type": "external" } ], "mass": 418424.0, "length": 3938, "protein_name": "Protein bassoon", "gene_name": "Bsn", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Bsn", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein bassoon", "protein_names_refseq": "", "tax_id": 10116, "disease": "epilepsy (Disease Ontology:DOID:1826)", "pathway": " (rno:29138)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10564375;12163476;12812759;14734538;15340146;16452088;17496889;18683930;19322778;21700703;22875941;23403927;25652077;26212709;27907191;29150638;38843836;9679147", "class_list": "", "function": "Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (PubMed:22875941). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (PubMed:22875941). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (PubMed:27907191). Also functions in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy by associating with ATG5 (PubMed:23403927, PubMed:27907191). Also mediates synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (PubMed:25652077). Inhibits the activity of the proportion of DAO enzyme that localizes to the presynaptic active zone, which may modulate synaptic transmission (PubMed:21700703)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 21, "predicted_n_glycosites": 0, "predicted_o_glycosites": 21, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 25, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 23, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0098882 structural constituent of presynaptic active zone;GO:0004857 enzyme inhibitor activity;GO:0008270 zinc ion binding;GO:0045503 dynein light chain binding;GO:0001222 transcription corepressor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0098831 presynaptic active zone cytoplasmic component;GO:1990257 piccolo-bassoon transport vesicle;GO:0005798 Golgi-associated vesicle", "go_biological_process": "GO:0008090 retrograde axonal transport;GO:0097091 synaptic vesicle clustering;GO:0008088 axo-dendritic transport;GO:0050808 synapse organization;GO:0007010 cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "O88778-1", "record_type": "protein", "filter_code": "0000000.1100111.001000.000000000000001000.0100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZU7-1", "uniprot_id": [ { "id": "BODG_RAT", "url": "https://www.uniprot.org/uniprot/Q9QZU7", "type": "external" } ], "mass": 44546.0, "length": 387, "protein_name": "Gamma-butyrobetaine dioxygenase", "gene_name": "Bbox1", "organism": "Rat", "refseq_name": "gamma-butyrobetaine dioxygenase", "refseq_ac": [ { "id": "NP_072151", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_072151", "type": "external" } ], "gene_names_uniprotkb": "Bbox1; Bbh", "gene_names_refseq": "Bbh; Bbox1; Bbox", "protein_names_uniprotkb": "Gamma-butyrobetaine dioxygenase; 1.14.11.1; Gamma-BBH; Gamma-butyrobetaine hydroxylase; Gamma-butyrobetaine,2-oxoglutarate dioxygenase", "protein_names_refseq": "butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1; butyrobetaine (gamma), 2-oxoglutarate dioxygenase 1 (gamma-butyrobetaine hydroxylase); gamma butyrobetaine hydroxylase; gamma-BBH; gamma-butyrobetaine dioxygenase; gamma-butyrobetaine,2-oxoglutarate dioxygenase", "tax_id": 10116, "disease": "", "pathway": " (rno:64564); (R-RNO-71262)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10526231;11964131;15795431;19150623;22014179;22673903;9753662", "class_list": "", "function": "Alterations in enzyme activities in the pivalate-treated rats are not regulated at the transcriptional level, and are apparently related to post-transcriptional effects on the enzymes themselves., [RefSeq, PubMed]; BBH mRNA, however, was detected during the suckling period onwards and its abundance was not changed significantly by maturation, [RefSeq, PubMed]; Catalyzes the formation of L-carnitine from gamma-butyrobetaine., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Data suggest that expression of BBH mRNA and protein is up-regulated in liver with training in physical activity; in kidney, only BBH mRNA expression is up-regulated., [RefSeq, PubMed]; Thyroid hormone controls carnitine status through modifications of gamma-butyrobetaine hydroxylase activity and gene expression, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.1", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0008336 gamma-butyrobetaine dioxygenase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0045329 carnitine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9QZU7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q00972-1", "uniprot_id": [ { "id": "BCKD_RAT", "url": "https://www.uniprot.org/uniprot/Q00972", "type": "external" } ], "mass": 46474.0, "length": 412, "protein_name": "Branched-chain alpha-ketoacid dehydrogenase kinase", "gene_name": "Bckdk", "organism": "Rat", "refseq_name": "branched-chain alpha-ketoacid dehydrogenase kinase precursor", "refseq_ac": [ { "id": "NP_062117", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062117", "type": "external" } ], "gene_names_uniprotkb": "Bckdk; Kat8", "gene_names_refseq": "BDK; Bckdk", "protein_names_uniprotkb": "Branched-chain alpha-ketoacid dehydrogenase kinase; 2.7.11.1; 2.7.11.4; BCKDH kinase; BCKDHKIN; BDK; [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial", "protein_names_refseq": "BCKD-kinase; BCKDH kinase; BCKDHKIN; [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial; branched-chain alpha-ketoacid dehydrogenase kinase precursor; branched-chain alpha-ketoacid dehydrogenase kinase", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); scoliosis (Disease Ontology:DOID:0060249); Ehlers-Danlos syndrome arthrochalasia type 2 (Disease Ontology:DOID:0080728); Ehlers-Danlos syndrome cardiac valvular type (Disease Ontology:DOID:0080730); branched-chain keto acid dehydrogenase kinase deficiency (Disease Ontology:DOID:0090126); osteogenesis imperfecta type 3 (Disease Ontology:DOID:0110339); osteogenesis imperfecta type 4 (Disease Ontology:DOID:0110340); osteogenesis imperfecta type 2 (Disease Ontology:DOID:0110341); intracranial aneurysm (Disease Ontology:DOID:10941); osteoporosis (Disease Ontology:DOID:11476); osteogenesis imperfecta (Disease Ontology:DOID:12347); dilated cardiomyopathy (Disease Ontology:DOID:12930); Ehlers-Danlos syndrome (Disease Ontology:DOID:13359); oligospermia (Disease Ontology:DOID:14228); hypothyroidism (Disease Ontology:DOID:1459); breast cancer (Disease Ontology:DOID:1612); pulmonary fibrosis (Disease Ontology:DOID:3770); heart valve disease (Disease Ontology:DOID:4079); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); ureteral obstruction (Disease Ontology:DOID:5199); muscular atrophy (Disease Ontology:DOID:767)", "pathway": " (rno:29603); (R-RNO-70895)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11562470;1377677;1496922;22673903;29779826;7649998", "class_list": "", "function": "Serine/threonine-protein kinase component of macronutrients metabolism. Forms a functional kinase and phosphatase pair with PPM1K, serving as a metabolic regulatory node that coordinates branched-chain amino acids (BCAAs) with glucose and lipid metabolism via two distinct phosphoprotein targets: mitochondrial BCKDHA subunit of the branched-chain alpha-ketoacid dehydrogenase (BCKDH) complex and cytosolic ACLY, a lipogenic enzyme of Krebs cycle (Probable) (PubMed:1377677, PubMed:7649998). Phosphorylates and inactivates mitochondrial BCKDH complex a multisubunit complex consisting of three multimeric components each involved in different steps of BCAA catabolism: E1 composed of BCKDHA and BCKDHB, E2 core composed of DBT monomers, and E3 composed of DLD monomers. Associates with the E2 component of BCKDH complex and phosphorylates BCKDHA on Ser-333, leading to conformational changes that interrupt substrate channeling between E1 and E2 and inactivates the BCKDH complex (Probable) (PubMed:1377677, PubMed:7649998). phosphorylates ACLY on Ser-455 in response to changes in cellular carbohydrate abundance such as occurs during fasting to feeding metabolic transition. Refeeding stimulates MLXIPL/ChREBP transcription factor, leading to increased BCKDK to PPM1K expression ratio, phosphorylation and activation of ACLY that ultimately results in the generation of malonyl-CoA and oxaloacetate immediate substrates of de novo lipogenesis and glucogenesis, respectively (Probable). Recognizes phosphosites having SxxE/D canonical motif (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q64552", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "1.2.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.4", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.3.1.259", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.259", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.3.1.80", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.80", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0045252 oxoglutarate dehydrogenase complex;GO:0031981 nuclear lumen;GO:0000785 chromatin", "go_biological_process": "GO:0007283 spermatogenesis;GO:0008610 lipid biosynthetic process;GO:0010906 regulation of glucose metabolic process;GO:0009083 branched-chain amino acid catabolic process;GO:0006574 L-valine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q00972-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66HD8-1", "uniprot_id": [ { "id": "F221B_RAT", "url": "https://www.uniprot.org/uniprot/Q66HD8", "type": "external" } ], "mass": 57157.0, "length": 507, "protein_name": "Protein FAM221B", "gene_name": "Fam221b", "organism": "Rat", "refseq_name": "protein FAM221B", "refseq_ac": [ { "id": "NP_001013956", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013956", "type": "external" } ], "gene_names_uniprotkb": "Fam221b", "gene_names_refseq": "Fam221b", "protein_names_uniprotkb": "Protein FAM221B", "protein_names_refseq": "protein FAM221B; uncharacterized protein C9orf128 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:298398)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q66HD8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P25023-1", "uniprot_id": [ { "id": "BKRB2_RAT", "url": "https://www.uniprot.org/uniprot/P25023", "type": "external" } ], "mass": 44930.0, "length": 396, "protein_name": "B2 bradykinin receptor", "gene_name": "Bdkrb2", "organism": "Rat", "refseq_name": "B2 bradykinin receptor isoform 2", "refseq_ac": [ { "id": "NP_775123", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775123", "type": "external" } ], "gene_names_uniprotkb": "Bdkrb2", "gene_names_refseq": "B2BKR; B2BRA; Bdkrb2", "protein_names_uniprotkb": "B2 bradykinin receptor; B2R; BK-2 receptor", "protein_names_refseq": "B2 bradykinin receptor isoform 2; B2 bradykinin receptor; B2R; BK-2 receptor; bradykinin receptor, beta 2", "tax_id": 10116, "disease": "rheumatic heart disease (Disease Ontology:DOID:0050827); renal fibrosis (Disease Ontology:DOID:0050855); pleurisy (Disease Ontology:DOID:10247); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); dilated cardiomyopathy (Disease Ontology:DOID:12930); Ehlers-Danlos syndrome (Disease Ontology:DOID:13359); bladder neck obstruction (Disease Ontology:DOID:13948); vascular type Ehlers-Danlos syndrome (Disease Ontology:DOID:14756); Ehlers-Danlos syndrome hypermobility type (Disease Ontology:DOID:14757); epilepsy (Disease Ontology:DOID:1826); asthma (Disease Ontology:DOID:2841); high grade glioma (Disease Ontology:DOID:3070); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); systemic scleroderma (Disease Ontology:DOID:418); rhinitis (Disease Ontology:DOID:4483); pancreatitis (Disease Ontology:DOID:4989); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); end stage renal disease (Disease Ontology:DOID:783); lung disease (Disease Ontology:DOID:850); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25245); (R-RNO-375276); (R-RNO-416476); (R-RNO-418594)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "10085087;1715575;27628189;30580020;31086419;33687297;7929432;8086459;8394991;8652530", "class_list": "", "function": "High bradykinin receptor B2 expression is associated with spinal cord ischemia-reperfusion injury., [RefSeq, PubMed]; Mas receptor antagonist abolished relaxation while bradykinin receptor antagonist only slightly reduced it, suggesting that bradykinin-induced vasorelaxation is regulated also by other mechanisms than the classical BR1/BR2 pathway., [RefSeq, PubMed]; Myocardial angiogenesis induced by exercise training involves a regulatory mechanism mediated by kinin receptors., [RefSeq, PubMed]; Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]; This is the first study that provides evidence supporting the existence of bradykinin receptor B2 - thromboxane TP receptors heteromerization fingerprints in primary cultured vascular smooth muscle cell. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 24, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031698 beta-2 adrenergic receptor binding;GO:0002020 protease binding;GO:0046982 protein heterodimerization activity;GO:0031702 type 1 angiotensin receptor binding;GO:0004947 bradykinin receptor activity", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0008285 negative regulation of cell population proliferation;GO:0042311 vasodilation;GO:0045776 negative regulation of blood pressure", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P25023-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KMA0-1", "uniprot_id": [ { "id": "AZI2_RAT", "url": "https://www.uniprot.org/uniprot/Q4KMA0", "type": "external" } ], "mass": 45986.0, "length": 404, "protein_name": "5-azacytidine-induced protein 2", "gene_name": "Azi2", "organism": "Rat", "refseq_name": "5-azacytidine-induced protein 2", "refseq_ac": [ { "id": "NP_001020876", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020876", "type": "external" } ], "gene_names_uniprotkb": "Azi2", "gene_names_refseq": "Azi2", "protein_names_uniprotkb": "5-azacytidine-induced protein 2", "protein_names_refseq": "5-azacytidine induced gene 2; 5-azacytidine-induced protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:316051)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;25691576", "class_list": "", "function": "Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity (By similarity). Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization (By similarity). Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1 (By similarity). Promotes TBK1-induced as well as TNF or PMA-induced activation of NF-kappa-B (By similarity). Participates in IFNB promoter activation via TICAM1 (By similarity)., [UniProtKB, UniProtKB]; Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1., [UniProtKB, UniProtKB]; Data indicate that 5-Azacytidine-induced protein 2 (AZI2) deficiency mice Are osteoporotic., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0042110 T cell activation;GO:0043124 negative regulation of canonical NF-kappaB signal transduction;GO:0097028 dendritic cell differentiation;GO:0044565 dendritic cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4KMA0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01161-1", "uniprot_id": [ { "id": "ANF_RAT", "url": "https://www.uniprot.org/uniprot/P01161", "type": "external" } ], "mass": 16556.0, "length": 152, "protein_name": "Natriuretic peptides A", "gene_name": "Nppa", "organism": "Rat", "refseq_name": "natriuretic peptides A precursor", "refseq_ac": [ { "id": "NP_036744", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036744", "type": "external" } ], "gene_names_uniprotkb": "Nppa", "gene_names_refseq": "ANF; ANP; CDD; Nppa; Pnd; RATANF", "protein_names_uniprotkb": "Natriuretic peptides A; ANF 1-33; ANF 3-33; ANF 8-33; ANF; Alpha-atrial natriuretic peptide; Alpha-hANP; Atrial natriuretic factor 1-33; Atrial natriuretic factor 3-33; Atrial natriuretic factor 8-33; Atrial natriuretic factor prohormone; Atrial natriuretic factor; Atrial natriuretic peptide prohormone; Atriopeptigen; Atriopeptin III; Atriopeptin II; Atriopeptin I; CDD 95-126; CDD-ANF; CDD-ANP (95-126); CDD-ANP (99-126); CDD; Cardiodilatin; Cardionatrin; LANH; Long-acting natriuretic hormone; Pro atrial natriuretic factor 1-30; Pro atrial natriuretic factor 31-67; Pro atrial natriuretic factor 79-98; Pro atrial natriuretic factor 99-126; Pro atrial natriuretic peptide 1-30; Pro atrial natriuretic peptide 31-67; Pro atrial natriuretic peptide 79-98; Pro atrial natriuretic peptide 95-126; preproANF; preproANP; preproCDD-ANF; proANF 1-30; proANF 31-67; proANF 79-98; proANF 99-126; proANF; proANP 1-30; proANP 31-67; proANP 79-98; proANP 95-126; proANP", "protein_names_refseq": "Natriuretic peptide precursor A (pronatriodilatin, also Anf, Pnd); atrial natriuretic factor prohormone; atrial natriuretic peptide prohormone; atriopeptigen; cardiodilatin; natriuretic peptide precursor type A; natriuretic peptides A precursor; natriuretic peptides A; preproANF; preproANP; preproCDD-ANF; prepronatriodilatin; proANF; proANP", "tax_id": 10116, "disease": "familial atrial fibrillation (Disease Ontology:DOID:0050650); stroke (Disease Ontology:DOID:0051061); intrinsic cardiomyopathy (Disease Ontology:DOID:0060036); atrial standstill 2 (Disease Ontology:DOID:0080663); renal hypertension (Disease Ontology:DOID:1073); hypertension (Disease Ontology:DOID:10763); heart disease (Disease Ontology:DOID:114); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930); nephrosis (Disease Ontology:DOID:2527); glomerulonephritis (Disease Ontology:DOID:2921); acute kidney failure (Disease Ontology:DOID:3021); coronary artery disease (Disease Ontology:DOID:3393); ureteral obstruction (Disease Ontology:DOID:5199); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); chronic kidney disease (Disease Ontology:DOID:784); peritonitis (Disease Ontology:DOID:8283); diabetic retinopathy (Disease Ontology:DOID:8947); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24602); (R-RNO-5578768)", "pathway_count": 2, "publication_count": 23, "publication_id_list": "15117952;1837590;22673903;2525379;2951736;2962707;2966343;2966345;2985557;31386893;31541683;3160114;35509154;37924963;6232612;6233494;6234658;6238331;6239103;6328328;6419347;6547210;7831500", "class_list": "", "function": "Ameliorating effect of rutin against diclofenac-induced cardiac injury in rats with underlying function of FABP3, MYL3, and ANP., [RefSeq, PubMed]; Hormone produced in the kidneys that appears to be important for maintaining cardio-renal homeostasis. Mediates vasodilation, natriuresis and diuresis primarily in the renal system, in order to maintain the extracellular fluid volume and control the fluid-electrolyte balance. Specifically binds and stimulates cGMP production by renal transmembrane receptors, likely NPR1. Urodilatin not ANP, may be the natriuretic peptide responsible for the regulation of sodium and water homeostasis in the kidney., [UniProtKB, UniProtKB]; Hormone that plays a key role in mediating cardio-renal homeostasis, and is involved in vascular remodeling and regulating energy metabolism (By similarity). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins, such as PRKG1, that drive various biological responses (PubMed:15117952). Regulates vasodilation, natriuresis, diuresis and aldosterone synthesis and is therefore essential for regulating blood pressure, controlling the extracellular fluid volume and maintaining the fluid-electrolyte balance (PubMed:7831500). Also involved in inhibiting cardiac remodeling and cardiac hypertrophy by inducing cardiomyocyte apoptosis and attenuating the growth of cardiomyocytes and fibroblasts (By similarity). Plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus, and thus prevents pregnancy-induced hypertension (By similarity). In adipose tissue, acts in various cGMP- and PKG-dependent pathways to regulate lipid metabolism and energy homeostasis (By similarity). This includes up-regulating lipid metabolism and mitochondrial oxygen utilization by activating the AMP-activated protein kinase (AMPK), and increasing energy expenditure by acting via MAPK11 to promote the UCP1-dependent thermogenesis of brown adipose tissue (By similarity). Binds the clearance receptor NPR3 which removes the hormone from circulation (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB]; Hypoxia augments NaHS-induced ANP secretion via KATP channel, HIF-1A and PPAR-gamma pathway., [RefSeq, PubMed]; May have a role in cardio-renal homeostasis through regulation of diuresis and inhibiting aldosterone synthesis. In vitro, promotes the production of cGMP and induces vasodilation. May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+-ATPase. May have a role in potassium excretion but not sodium excretion (natriuresis). Possibly enhances protein excretion in urine by decreasing proximal tubular protein reabsorption., [UniProtKB, UniProtKB]; May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis and in vitro, vasodilates renal artery strips., [UniProtKB, PubMed, PubMed]; May have a role in cardio-renal homeostasis through regulation of natriuresis, diuresis, and vasodilation (By similarity). In vitro, promotes the production of cGMP and induces vasodilation (By similarity). May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+-ATPase (By similarity). However reports on the involvement of this peptide in mammal blood volume and blood pressure homeostasis are conflicting; according to a report, in vivo it is not sufficient to activate cGMP and does not inhibit collecting duct transport nor effect diuresis and natriuresis (PubMed:7831500). Appears to bind to specific receptors that are distinct from the receptors bound by the atrial natriuretic and long-acting natriuretic peptides (By similarity). Possibly functions in protein excretion in urine by maintaining the integrity of the proximal tubules and enhancing protein excretion by decreasing proximal tubular protein reabsorption (By similarity)., [UniProtKB, PubMed, UniProtKB]; May have a role in cardio-renal homeostasis through regulation of natriuresis, diuresis, vasodilation, and inhibiting aldosterone synthesis (By similarity). In vitro, promotes the production of cGMP and induces vasodilation (By similarity). May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+-ATPase (By similarity). However reports on the involvement of this peptide in mammal blood volume and blood pressure homeostasis are conflicting; according to a report, in vivo it is not sufficient to activate cGMP and does not inhibit collecting duct transport nor effect diuresis and natriuresis (PubMed:7831500). Appears to bind to specific receptors that are distinct from the receptors bound by atrial natriuretic peptide and vessel dilator. Possibly enhances protein excretion in urine by decreasing proximal tubular protein reabsorption (By similarity)., [UniProtKB, PubMed, UniProtKB]; May have a role in cardio-renal homeostasis through regulation of regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, vasodilates intestinal smooth muscle but not smooth muscle strips., [UniProtKB, PubMed]; These results indicate that endogenous ET-1 induced by hypoxia promotes hypoxia-induced ANP secretion by activation of COX2-L-PGDS-PPARgamma signaling in beating rat atria, [RefSeq, PubMed]; Underlying mechanism of atrial fibrillation-associated Nppa-I137T mutation and cardiac effect of potential drug therapy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005184 neuropeptide hormone activity;GO:0005179 hormone activity;GO:0051427 hormone receptor binding;GO:0071855 neuropeptide receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005903 brush border;GO:0043204 perikaryon;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:1904385 cellular response to angiotensin;GO:1904681 response to 3-methylcholanthrene;GO:0006182 cGMP biosynthetic process;GO:0007218 neuropeptide signaling pathway;GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P01161-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P05370-1", "uniprot_id": [ { "id": "G6PD_RAT", "url": "https://www.uniprot.org/uniprot/P05370", "type": "external" } ], "mass": 59376.0, "length": 515, "protein_name": "Glucose-6-phosphate 1-dehydrogenase", "gene_name": "G6pdx", "organism": "Rat", "refseq_name": "glucose-6-phosphate 1-dehydrogenase", "refseq_ac": [ { "id": "NP_058702", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058702", "type": "external" } ], "gene_names_uniprotkb": "G6pdx; G6pd", "gene_names_refseq": "G6pdx; G6pd", "protein_names_uniprotkb": "Glucose-6-phosphate 1-dehydrogenase; 1.-.-.-; 1.1.1.49; G6PD", "protein_names_refseq": "glucose-6-phosphate 1-dehydrogenase; glucose-6-phosphate dehydrogenase X-linked", "tax_id": 10116, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); congenital nonspherocytic hemolytic anemia 1 (Disease Ontology:DOID:0051003); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); hypertension (Disease Ontology:DOID:10763); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); malaria (Disease Ontology:DOID:12365); hepatic encephalopathy (Disease Ontology:DOID:13413); cholestasis (Disease Ontology:DOID:13580); favism (Disease Ontology:DOID:13628); Plasmodium falciparum malaria (Disease Ontology:DOID:14067); renovascular hypertension (Disease Ontology:DOID:1591); transient cerebral ischemia (Disease Ontology:DOID:224); anemia (Disease Ontology:DOID:2355); neonatal jaundice (Disease Ontology:DOID:2383); congenital nonspherocytic hemolytic anemia (Disease Ontology:DOID:2861); kidney disease (Disease Ontology:DOID:557); hemolytic anemia (Disease Ontology:DOID:583); myocardial infarction (Disease Ontology:DOID:5844); cerebrovascular disease (Disease Ontology:DOID:6713); hepatocellular carcinoma (Disease Ontology:DOID:684); cataract (Disease Ontology:DOID:83); hyperhomocysteinemia (Disease Ontology:DOID:9279); phenylketonuria (Disease Ontology:DOID:9281); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24377); (R-RNO-5628897); (R-RNO-71336)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "2606104;33964586;3412913;36321738;36372233;38069050;38876306", "class_list": "", "function": "Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis. Also catalyzes the conversion of NAADPH, which is produced by enzymes such as DUOX1, DUOX2 and NOX5 from NAADP and promotes Ca(2+) signaling during T cell activation, back to NAADP., [UniProtKB, UniProtKB]; G6PD Orchestrates Genome-Wide DNA Methylation and Gene Expression in the Vascular Wall. Publication Status: Online-Only, [RefSeq, PubMed]; HSPB1 overexpression improves hypoxic-ischemic brain damage by attenuating ferroptosis in rats through promoting G6PD expression., [RefSeq, PubMed]; Loss-of-function G6PD variant moderated high-fat diet-induced obesity, adipocyte hypertrophy, and fatty liver in male rats., [RefSeq, PubMed]; Mediterranean G6PD variant mitigates expression of DNA methyltransferases and right heart pressure in experimental model of pulmonary hypertension., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 27, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.31", "type": "external" }, { "id": "1.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.47", "type": "external" }, { "id": "1.1.1.363", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.363", "type": "external" }, { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "1.1.1.49", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.49", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0030246 carbohydrate binding;GO:0004345 glucose-6-phosphate dehydrogenase activity;GO:0050661 NADP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0009898 cytoplasmic side of plasma membrane;GO:0034451 centriolar satellite", "go_biological_process": "GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development;GO:0006739 NADP+ metabolic process;GO:0006741 NADP+ biosynthetic process;GO:0043249 erythrocyte maturation;GO:0006979 response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P05370-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23928-1", "uniprot_id": [ { "id": "CRYAB_RAT", "url": "https://www.uniprot.org/uniprot/P23928", "type": "external" } ], "mass": 20089.0, "length": 175, "protein_name": "Alpha-crystallin B chain", "gene_name": "Cryab", "organism": "Rat", "refseq_name": "alpha-crystallin B chain", "refseq_ac": [ { "id": "NP_037067", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037067", "type": "external" } ], "gene_names_uniprotkb": "Cryab", "gene_names_refseq": "AACRYA; Cryab", "protein_names_uniprotkb": "Alpha-crystallin B chain; Alpha(B)-crystallin", "protein_names_refseq": "Crystallin, alpha polypeptide 2; alpha(B)-crystallin; alpha-crystallin B chain", "tax_id": 10116, "disease": "adult-onset myofibrillar myopathy 2A (Disease Ontology:DOID:0080093); infantile-onset myofibrillar myopathy-2B (Disease Ontology:DOID:0080309); Charcot-Marie-Tooth disease axonal type 2L (Disease Ontology:DOID:0110174); cataract 16 multiple types (Disease Ontology:DOID:0110250); dilated cardiomyopathy 1II (Disease Ontology:DOID:0110450); autosomal dominant distal hereditary motor neuronopathy 2 (Disease Ontology:DOID:0111206); macular degeneration (Disease Ontology:DOID:4448); cataract (Disease Ontology:DOID:83)", "pathway": " (rno:25420); (R-RNO-3371571)", "pathway_count": 2, "publication_count": 25, "publication_id_list": "10100856;10751411;12205038;14985449;16641100;1730617;1764082;1765091;1783614;21615407;2176207;22673903;23110217;23543138;24950024;25900025;2912453;32016842;32554860;33220080;34502162;37584866;8282729;8639509;9368070", "class_list": "", "function": "Alpha crystallin is a moonlighting protein that functions as a heat shock protein as well as a lens crystallin., [RefSeq, PubMed]; Evidence of the involvement of spinal alphaB-crystallin in the maintenance of bone cancer pain in rats., [RefSeq, PubMed]; HspB5/alphaB-crystallin phosphorylation at S45 and S59 is essential for protection of the dendritic tree of rat hippocampal neurons., [RefSeq, PubMed]; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. In lens epithelial cells, stabilizes the ATP6V1A protein, preventing its degradation by the proteasome (By similarity)., [UniProtKB, UniProtKB]; Regulation of rat HspB5/alphaB-Crystallin by microRNAs miR-101a-3p, miR-140-5p, miR-330-5p, and miR-376b-3p., [RefSeq, PubMed]; The transcription factor CREB acts as an important regulator mediating oxidative stress-induced apoptosis by suppressing alphaB-crystallin expression., [RefSeq, PubMed]; This gene encodes subunit b, one of two subunits of alpha-crystallin, which is a high molecular weight, soluble aggregate and is a member of the small heat shock protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. It acts as a molecular chaperone and is the major protein in the eye lens, maintaining the transparency and refractive index of the lens. Alternate promoter usage results in different transcript variants encoding the same protein. [provided by RefSeq, Sep 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 0, "mined_o_glycosites": 1, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6LDR2", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0051082 unfolded protein binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0032387 negative regulation of intracellular transport;GO:0010629 negative regulation of gene expression;GO:0043066 negative regulation of apoptotic process;GO:0001666 response to hypoxia;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P23928-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100010000001.110.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03351-1", "uniprot_id": [ { "id": "NTRK3_RAT", "url": "https://www.uniprot.org/uniprot/Q03351", "type": "external" } ], "mass": 97064.0, "length": 864, "protein_name": "NT-3 growth factor receptor", "gene_name": "Ntrk3", "organism": "Rat", "refseq_name": "NT-3 growth factor receptor isoform 2 precursor", "refseq_ac": [ { "id": "NP_001257584", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257584", "type": "external" } ], "gene_names_uniprotkb": "Ntrk3; Trkc", "gene_names_refseq": "Ntrk3; trkC", "protein_names_uniprotkb": "NT-3 growth factor receptor; 2.7.10.1; GP145-TrkC; Neurotrophic tyrosine kinase receptor type 3; Trk-C; TrkC tyrosine kinase", "protein_names_refseq": "GP145-TrkC; NT-3 growth factor receptor isoform 2 precursor; NT-3 growth factor receptor; neural receptor protein-tyrosine kinase (trkC); neurotrophic tyrosine kinase, receptor, type 3; trk-C; trkC tyrosine kinase", "tax_id": 10116, "disease": "spinocerebellar ataxia 26 (Disease Ontology:DOID:0050975); adenoid cystic carcinoma (Disease Ontology:DOID:0080202); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); glaucoma (Disease Ontology:DOID:1686); rectum adenocarcinoma (Disease Ontology:DOID:1996); colon adenocarcinoma (Disease Ontology:DOID:234); invasive ductal carcinoma (Disease Ontology:DOID:3008); brain glioblastoma multiforme (Disease Ontology:DOID:3073); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); borna disease (Disease Ontology:DOID:5154); lung small cell carcinoma (Disease Ontology:DOID:5409); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:29613); (R-RNO-1257604); (R-RNO-388844); (R-RNO-6811558); (R-RNO-9034013); (R-RNO-9034793); (R-RNO-9603381)", "pathway_count": 7, "publication_count": 12, "publication_id_list": "12471037;1488112;15167895;17967490;21775604;27830679;28614398;34970951;38843836;8494647;8494648;9856458", "class_list": "", "function": "Data show that 5-Aza-dc reversed the alcohol-induced downregulation of neurotrophin-3 (Ntf3), correspondingly the expression of its receptor-neurotrophic receptor tyrosine kinase 3 (TrkC) was reduced. Publication Status: Online-Only, [RefSeq, PubMed]; It has been shown that ischemia influenced the expression of neurotrophins (Bdnf, Ngf, Nt-3) and their receptors (TrkB, TrkA, TrkC, p75) in brain structures outside the lesion focus, including the contralateral hemisphere., [RefSeq, PubMed]; P75NTR Exacerbates SCI-induced Mitochondrial Damage and Neuronal Apoptosis Depending on NTRK3., [RefSeq, PubMed]; Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation (By similarity). NTRK3 isoforms containing insertions within the kinase domain can autophosphorylate in response to NTF3/neurotrophin-3, but cannot mediate downstream phenotypic responses (PubMed:8494647, PubMed:8494648)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 15, "predicted_n_glycosites": 14, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 16, "glyco_site_count": 15, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" } ], "go_molecular_function": "GO:0043121 neurotrophin binding;GO:0005524 ATP binding;GO:0004675 transmembrane receptor protein serine/threonine kinase activity;GO:0004714 transmembrane receptor protein tyrosine kinase activity;GO:0002039 p53 binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0097107 postsynaptic density assembly;GO:0042490 mechanoreceptor differentiation;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007507 heart development;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q03351-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KM77-1", "uniprot_id": [ { "id": "EI24_RAT", "url": "https://www.uniprot.org/uniprot/Q4KM77", "type": "external" } ], "mass": 38893.0, "length": 340, "protein_name": "Etoposide-induced protein 2.4 homolog", "gene_name": "Ei24", "organism": "Rat", "refseq_name": "etoposide-induced protein 2.4 homolog", "refseq_ac": [ { "id": "NP_001020831", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020831", "type": "external" } ], "gene_names_uniprotkb": "Ei24", "gene_names_refseq": "Ei24", "protein_names_uniprotkb": "Etoposide-induced protein 2.4 homolog", "protein_names_refseq": "etoposide induced 2.4 mRNA; etoposide-induced protein 2.4 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:300514)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "20550938;22673903;29769309", "class_list": "", "function": "Acts as a negative growth regulator via p53-mediated apoptosis pathway. Regulates formation of degradative autolysosomes during autophagy., [UniProtKB, PubMed]; Etoposide-induced protein 2.4 functions as a regulator of the calcium ATPase and protects pancreatic beta-cell survival, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0061676 importin-alpha family protein binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0050885 neuromuscular process controlling balance;GO:0016236 macroautophagy;GO:0006914 autophagy;GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage;GO:0030308 negative regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q4KM77-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62894-1", "uniprot_id": [ { "id": "ECM1_RAT", "url": "https://www.uniprot.org/uniprot/Q62894", "type": "external" } ], "mass": 63249.0, "length": 562, "protein_name": "Extracellular matrix protein 1", "gene_name": "Ecm1", "organism": "Rat", "refseq_name": "extracellular matrix protein 1 precursor", "refseq_ac": [ { "id": "NP_446334", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446334", "type": "external" } ], "gene_names_uniprotkb": "Ecm1", "gene_names_refseq": "Ecm1", "protein_names_uniprotkb": "Extracellular matrix protein 1; Secretory component p85", "protein_names_refseq": "extracellular matrix protein 1 precursor; secretory component p85", "tax_id": 10116, "disease": "lipoid proteinosis (Disease Ontology:DOID:14498)", "pathway": " (rno:116662); (R-RNO-114608)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22673903;26479776", "class_list": "", "function": "Involved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q5U2S9", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0005134 interleukin-2 receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0001960 negative regulation of cytokine-mediated signaling pathway;GO:0010466 negative regulation of peptidase activity;GO:0001525 angiogenesis;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006954 inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q62894-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63276-1", "uniprot_id": [ { "id": "BAAT_RAT", "url": "https://www.uniprot.org/uniprot/Q63276", "type": "external" } ], "mass": 46465.0, "length": 420, "protein_name": "Bile acid-CoA:amino acid N-acyltransferase", "gene_name": "Baat", "organism": "Rat", "refseq_name": "bile acid-CoA:amino acid N-acyltransferase", "refseq_ac": [ { "id": "NP_058996", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058996", "type": "external" } ], "gene_names_uniprotkb": "Baat", "gene_names_refseq": "Baat; kan-1", "protein_names_uniprotkb": "Bile acid-CoA:amino acid N-acyltransferase; 2.3.1.65; 3.1.2.27; 3.1.2.2; BACAT; BAT; Bile acid-CoA thioesterase; Choloyl-CoA hydrolase; Glycine N-choloyltransferase; Kan-1; Long-chain fatty-acyl-CoA hydrolase", "protein_names_refseq": "BACAT; BAT; bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase); bile acid-CoA thioesterase; bile acid-CoA:amino acid N-acyltransferase; bile acid-Coenzyme A dehydrogenase: amino acid n-acyltransferase; bile acid-Coenzyme A: amino acid N-acyltransferase; choloyl-CoA hydrolase; glycine N-choloyltransferase; long-chain fatty-acyl-CoA hydrolase", "tax_id": 10116, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); familial hypercholanemia 3 (Disease Ontology:DOID:0061180); congenital myasthenic syndrome 19 (Disease Ontology:DOID:0110673)", "pathway": " (rno:29725); (R-RNO-159418); (R-RNO-193368); (R-RNO-9033241)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "12951368;17256745;17483744;19008781;22673903;624713;7575455", "class_list": "", "function": "Catalyzes the amidation of bile acids (BAs) with the amino acids taurine and glycine (PubMed:12951368, PubMed:624713). More efficient at taurine conjugation of cholyl CoA than glycine conjugation (PubMed:12951368, PubMed:624713). Amidation of BAs in the liver with glycine or taurine prior to their excretion into bile is an important biochemical event in bile acid metabolism (By similarity). This conjugation (or amidation) plays several important biological roles in that it promotes the secretion of BAs and cholesterol into bile and increases the detergent properties of BAs in the intestine, which facilitates lipid and vitamin absorption (By similarity). May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids (By similarity). In vitro, catalyzes the hydrolysis of long- and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A (CoASH), and conjugates glycine to these acyl-CoAs (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; Dex restored the expression of rBAT in septic rats by enhancing RXR[alpha], a process that might explain the mechanism underlying Dex's anticholestatic effect., [RefSeq, PubMed]; HBAAT and rBaat are peroxisomal enzymes present in undetectable amounts in the cytosol. Unconjugated or deconjugated bile salts returning to the liver need to shuttle through the peroxisome before reentering the enterohepatic circulation., [RefSeq, PubMed]; Mechanisms of RXR-alpha-mediated BAAT regulation during polymicrobial sepsis, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5M8A2", "ec_number_list": [ { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "1.2.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "1.4.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "3.5.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.6", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" }, { "id": "3.1.2.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.14", "type": "external" }, { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "5.1.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "4.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.9", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" } ], "go_molecular_function": "GO:0033882 choloyl-CoA hydrolase activity;GO:0047617 fatty acyl-CoA hydrolase activity;GO:0052689 carboxylic ester hydrolase activity;GO:0052815 medium-chain fatty acyl-CoA hydrolase activity;GO:0016410 N-acyltransferase activity", "go_cellular_component": "GO:0005777 peroxisome;GO:0005829 cytosol", "go_biological_process": "GO:0001889 liver development;GO:0006631 fatty acid metabolic process;GO:0006637 acyl-CoA metabolic process;GO:0006699 bile acid biosynthetic process;GO:0008206 bile acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q63276-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q641Z6-1", "uniprot_id": [ { "id": "EHD1_RAT", "url": "https://www.uniprot.org/uniprot/Q641Z6", "type": "external" } ], "mass": 60603.0, "length": 534, "protein_name": "EH domain-containing protein 1", "gene_name": "Ehd1", "organism": "Rat", "refseq_name": "EH domain-containing protein 1", "refseq_ac": [ { "id": "NP_001011939", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011939", "type": "external" } ], "gene_names_uniprotkb": "Ehd1", "gene_names_refseq": "Ehd1; RGD1306960", "protein_names_uniprotkb": "EH domain-containing protein 1", "protein_names_refseq": "EH domain-containing protein 1", "tax_id": 10116, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:293692); (R-RNO-983231)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "15930129;22673903;23572513;27211346;30320922;32138615", "class_list": "", "function": "ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes vesiculation of endocytic membranes (By similarity). Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes (By similarity). Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth (PubMed:23572513). Plays a role in myoblast fusion (By similarity). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing (By similarity). Plays a role in the formation of the ciliary vesicle (CV), an early step in cilium biogenesis. Proposed to be required for the fusion of distal appendage vesicles (DAVs) to form the CV by recruiting SNARE complex component SNAP29. Is required for recruitment of transition zone proteins CEP290, RPGRIP1L, TMEM67 and B9D2, and of IFT20 following DAV reorganization before Rab8-dependent ciliary membrane extension. Required for the loss of CCP110 form the mother centriole essential for the maturation of the basal body during ciliogenesis (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; EHD1 Modulates Cx43 Gap Junction Remodeling Associated With Cardiac Diseases., [RefSeq, PubMed]; Our data delineate a novel interaction between Triad1 and EHD1 that may contribute to the regulation of neurite outgrowth for neurons after the spinal cord injury., [RefSeq, PubMed]; This study demonstrated that EHD1 was up-regulated in rat spinal cord injury model., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1H289", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome;GO:0005811 lipid droplet", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006897 endocytosis;GO:0010976 positive regulation of neuron projection development;GO:0031175 neuron projection development;GO:0051260 protein homooligomerization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q641Z6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64428-1", "uniprot_id": [ { "id": "ECHA_RAT", "url": "https://www.uniprot.org/uniprot/Q64428", "type": "external" } ], "mass": 82665.0, "length": 763, "protein_name": "Trifunctional enzyme subunit alpha, mitochondrial", "gene_name": "Hadha", "organism": "Rat", "refseq_name": "trifunctional enzyme subunit alpha, mitochondrial precursor", "refseq_ac": [ { "id": "NP_570839", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_570839", "type": "external" } ], "gene_names_uniprotkb": "Hadha", "gene_names_refseq": "Hadha; MLCL AT; RGD1560655", "protein_names_uniprotkb": "Trifunctional enzyme subunit alpha, mitochondrial; 2.3.1.-; MLCL AT; Monolysocardiolipin acyltransferase; TP-alpha", "protein_names_refseq": "TP-alpha; hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit; hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit; monolysocardiolipin acyltransferase; trifunctional enzyme subunit alpha, mitochondrial precursor; trifunctional enzyme subunit alpha, mitochondrial", "tax_id": 10116, "disease": "long chain 3-hydroxyacyl-CoA dehydrogenase deficiency (Disease Ontology:DOID:0061186); mitochondrial trifunctional protein deficiency 1 (Disease Ontology:DOID:0070619); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Alzheimer's disease (Disease Ontology:DOID:10652); lipid metabolism disorder (Disease Ontology:DOID:3146); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (rno:170670); (R-RNO-1482798); (R-RNO-77285); (R-RNO-77305); (R-RNO-77310); (R-RNO-77346); (R-RNO-77348); (R-RNO-77350)", "pathway_count": 8, "publication_count": 7, "publication_id_list": "1730633;22673903;26446791;27213235;34502162;38843836;8253773", "class_list": "", "function": "Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through cycles of four consecutive reactions. Each beta-oxidation cycle shortens the fatty acyl-CoA by two carbons, yielding one acetyl-CoA (for the citric acid cycle), one FADH(2), and one NADH (which donate electrons to the respiratory chain for ATP production). These cycles repeat until the chain is fully degraded to acetyl-CoA units. Among the enzymes involved in this pathway, the trifunctional protein--responsible for the hydration, dehydrogenation, and thiolysis steps, shows specificity for long-chain fatty acids, such as those from dietary and stored fats. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enzyme subunit alpha/HADHA described here carries the 2,3-enoyl-CoA hydratase and the 3-hydroxyacyl-CoA dehydrogenase activities while the trifunctional enzyme subunit beta/HADHB bears the 3-ketoacyl-CoA thiolase activity. These activities have been experimentally confirmed on a few substrates derived from beta-oxidation of long-chain saturated fatty acids such as palmitate (hexadecanoate) and laurate (dodecanoate). In addition, based on its established catalytic mechanism, and combined genetic interaction or mutant phenotype evidence, it is predicted to act also on other substrates, including long-chain unsaturated fatty acids such as oleate (9Z-octadecenoate), linoleate (9Z,12Z-octadecadienoate), linolenate (9Z,12Z,15Z-octadecatrienoate), and others. Independently of subunit beta, HADHA also exhibits a cardiolipin acyltransferase activity that participates in cardiolipin remodeling; cardiolipin is a major mitochondrial membrane phospholipid. HADHA may act downstream of Tafazzin/TAZ, that remodels monolysocardiolipin (MLCL) to a cardiolipin intermediate, and then HADHA may continue to remodel this species into mature tetralinoleoyl-cardiolipin. Has also been proposed to act directly on MLCL; capable of acylating MLCL using different acyl-CoA substrates, with highest activity for oleoyl-CoA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q5BIZ5", "ec_number_list": [ { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "4.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.17", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.1.1.211", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.211", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0016509 long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity;GO:0051287 NAD binding;GO:0044877 protein-containing complex binding;GO:0000062 fatty-acyl-CoA binding;GO:0070403 NAD+ binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0042645 mitochondrial nucleoid;GO:0016507 mitochondrial fatty acid beta-oxidation multienzyme complex", "go_biological_process": "GO:0006635 fatty acid beta-oxidation;GO:0032868 response to insulin;GO:0035965 cardiolipin acyl-chain remodeling;GO:0009410 response to xenobiotic stimulus", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q64428-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q792S6-1", "uniprot_id": [ { "id": "BOK_RAT", "url": "https://www.uniprot.org/uniprot/Q792S6", "type": "external" } ], "mass": 23456.0, "length": 213, "protein_name": "Bcl-2-related ovarian killer protein", "gene_name": "Bok", "organism": "Rat", "refseq_name": "bcl-2-related ovarian killer protein", "refseq_ac": [ { "id": "NP_059008", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059008", "type": "external" } ], "gene_names_uniprotkb": "Bok", "gene_names_refseq": "Bok-BH3; Bok", "protein_names_uniprotkb": "Bcl-2-related ovarian killer protein", "protein_names_refseq": "BCL2-related ovarian killer; BOK, BCL2 family apoptosis regulator; bcl-2-related ovarian killer protein", "tax_id": 10116, "disease": "hydrocephalus (Disease Ontology:DOID:10908); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (rno:29884)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "9356461;9804769", "class_list": "", "function": "Apoptosis regulator that functions through different apoptotic signaling pathways (PubMed:9356461, PubMed:9804769). Plays a roles as pro-apoptotic protein that positively regulates intrinsic apoptotic process in a BAX- and BAK1-dependent manner or in a BAX- and BAK1-independent manner (By similarity). In response to endoplasmic reticulum stress promotes mitochondrial apoptosis through downstream BAX/BAK1 activation and positive regulation of PERK-mediated unfolded protein response (By similarity). Activates apoptosis independently of heterodimerization with survival-promoting BCL2 and BCL2L1 through induction of mitochondrial outer membrane permeabilization, in a BAX- and BAK1-independent manner, in response to inhibition of ERAD-proteasome degradation system, resulting in cytochrome c release (By similarity). In response to DNA damage, mediates intrinsic apoptotic process in a TP53-dependent manner. Plays a role in granulosa cell apoptosis by CASP3 activation (By similarity). Plays a roles as anti-apoptotic protein during neuronal apoptotic process, by negatively regulating poly ADP-ribose polymerase-dependent cell death through regulation of neuronal calcium homeostasis and mitochondrial bioenergetics in response to NMDA excitation (By similarity). In addition to its role in apoptosis, may regulate trophoblast cell proliferation during the early stages of placental development, by acting on G1/S transition through regulation of CCNE1 expression. May also play a role as an inducer of autophagy by disrupting interaction between MCL1 and BECN1 (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed]; Positively regulates apoptotic process in an heterodimerization-independent manner with antiapoptotic Bcl-2 proteins., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88857", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0046983 protein dimerization activity;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0010506 regulation of autophagy;GO:0043065 positive regulation of apoptotic process;GO:0051259 protein complex oligomerization;GO:0051402 neuron apoptotic process;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q792S6-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91XJ1-1", "uniprot_id": [ { "id": "BECN1_RAT", "url": "https://www.uniprot.org/uniprot/Q91XJ1", "type": "external" } ], "mass": 51557.0, "length": 448, "protein_name": "Beclin-1", "gene_name": "Becn1", "organism": "Rat", "refseq_name": "beclin-1", "refseq_ac": [ { "id": "NP_001029289", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029289", "type": "external" } ], "gene_names_uniprotkb": "Becn1", "gene_names_refseq": "Beclin1; Becn1", "protein_names_uniprotkb": "Beclin-1; Coiled-coil myosin-like BCL2-interacting protein; Protein GT197", "protein_names_refseq": "beclin 1 (coiled-coil, myosin-like BCL2-interacting protein); beclin 1, autophagy related; beclin-1; coiled-coil myosin-like BCL2-interacting protein", "tax_id": 10116, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); polycystic kidney disease (Disease Ontology:DOID:0080322); Parkinsonism (Disease Ontology:DOID:0080855); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); anterior ischemic optic neuropathy (Disease Ontology:DOID:12010); Machado-Joseph disease (Disease Ontology:DOID:1440); depressive disorder (Disease Ontology:DOID:1596); breast cancer (Disease Ontology:DOID:1612); glaucoma (Disease Ontology:DOID:1686); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); glioblastoma (Disease Ontology:DOID:3068); ischemia (Disease Ontology:DOID:326); brain infarction (Disease Ontology:DOID:3454); middle cerebral artery infarction (Disease Ontology:DOID:3525); esophagus adenocarcinoma (Disease Ontology:DOID:4914); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); liver cirrhosis (Disease Ontology:DOID:5082); ureteral obstruction (Disease Ontology:DOID:5199); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); paraplegia (Disease Ontology:DOID:607); viral encephalitis (Disease Ontology:DOID:646); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); peritonitis (Disease Ontology:DOID:8283); osteoarthritis (Disease Ontology:DOID:8398); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677); diabetic retinopathy (Disease Ontology:DOID:8947); degenerative disc disease (Disease Ontology:DOID:90); Barrett's esophagus (Disease Ontology:DOID:9206); type 2 diabetes mellitus (Disease Ontology:DOID:9352); diabetic neuropathy (Disease Ontology:DOID:9743)", "pathway": " (rno:114558); (R-RNO-1169408); (R-RNO-1632852); (R-RNO-5689880)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "17724469;22314358;27994061;34830430;35266018;35818233;38261732", "class_list": "", "function": "Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors., [UniProtKB, UniProtKB, UniProtKB]; Beclin1 exerts protective effects against cerebral ischemiareperfusion injury by promoting DNA damage repair through a nonautophagydependent regulatory mechanism., [RefSeq, PubMed]; MicroRNA-141-3p reduces pulmonary hypoxia/reoxygenation injury through suppression of Beclin-1-dependent autophagy., [RefSeq, PubMed]; Plays a central role in autophagy. Acts as a core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abscission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis. May play a role in antiviral host defense (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Propofol Regulates the Expression of BecliN-1 through miR-30b and Protects against Lung Ischemia-Reperfusion Injury. Publication Status: Online-Only, [RefSeq, PubMed]; Synbiotics Alleviate Hepatic Damage, Intestinal Injury and Muscular Beclin-1 Elevation in Rats after Chronic Ethanol Administration. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 39, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019901 protein kinase binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0097352 autophagosome maturation;GO:1902902 negative regulation of autophagosome assembly;GO:0051707 response to other organism;GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process;GO:0000045 autophagosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q91XJ1-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4QQU5-1", "uniprot_id": [ { "id": "YIPF6_RAT", "url": "https://www.uniprot.org/uniprot/Q4QQU5", "type": "external" } ], "mass": 26107.0, "length": 236, "protein_name": "Protein YIPF6", "gene_name": "Yipf6", "organism": "Rat", "refseq_name": "protein YIPF6", "refseq_ac": [ { "id": "NP_001020918", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020918", "type": "external" } ], "gene_names_uniprotkb": "Yipf6", "gene_names_refseq": "Yipf6", "protein_names_uniprotkb": "Protein YIPF6; YIP1 family member 6", "protein_names_refseq": "YIP1 family member 6; protein YIPF6", "tax_id": 10116, "disease": "", "pathway": " (rno:363476); (R-RNO-432722)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "May be required for stable YIPF1 and YIPF2 protein expression., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0005797 Golgi medial cisterna;GO:0005801 cis-Golgi network", "go_biological_process": "GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0060576 intestinal epithelial cell development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4QQU5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R1U7-1", "uniprot_id": [ { "id": "S22A8_RAT", "url": "https://www.uniprot.org/uniprot/Q9R1U7", "type": "external" } ], "mass": 59186.0, "length": 536, "protein_name": "Organic anion transporter 3", "gene_name": "Slc22a8", "organism": "Rat", "refseq_name": "organic anion transporter 3", "refseq_ac": [ { "id": "NP_112622", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112622", "type": "external" } ], "gene_names_uniprotkb": "Slc22a8; Oat3", "gene_names_refseq": "OCT3; Oat3; Roct; Slc22a8", "protein_names_uniprotkb": "Organic anion transporter 3; Oat3; Organic anion/dicarboxylate exchanger; Solute carrier family 22 member 8", "protein_names_refseq": "organic anion transporter 3; organic anion/dicarboxylate exchanger; rOat3; solute carrier family 22 (organic anion transporter), member 8", "tax_id": 10116, "disease": "", "pathway": " (rno:83500); (R-RNO-561048)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "10224140;11861777;11961115;12102636;12488248;12660303;12684544;14675047;15292460;15319347;15389674;15846470;22673903;23832370;29393594;29436232;29980603;32101757;32271169;33790363", "class_list": "", "function": "Atorvastatin attenuates obese-induced kidney injury and impaired renal organic anion transporter 3 function through inhibition of oxidative stress and inflammation., [RefSeq, PubMed]; Data suggest that a remote sensing and signaling system between gut and kidney by which probiotic might facilitate renal handling of gut microbiota products through the improvement of organic anion transporter 3 (Oat3) function. Publication Status: Online-Only, [RefSeq, PubMed]; Functions as an organic anion/dicarboxylate exchanger that couples organic anion uptake indirectly to the sodium gradient (PubMed:12488248, PubMed:12660303). Transports organic anions such as estrone 3-sulfate (E1S) and urate in exchange for dicarboxylates such as glutarate or ketoglutarate (2-oxoglutarate) (PubMed:12488248, PubMed:12660303, PubMed:23832370). Plays an important role in the excretion of endogenous and exogenous organic anions, especially from the kidney and the brain (PubMed:10224140, PubMed:11961115, PubMed:12684544). E1S transport is pH- and chloride-dependent and may also involve E1S/cGMP exchange (By similarity). Responsible for the transport of prostaglandin E2 (PGE2) and prostaglandin F2(alpha) (PGF2(alpha)) in the basolateral side of the renal tubule (By similarity). Involved in the transport of neuroactive tryptophan metabolites kynurenate and xanthurenate (PubMed:23832370). Functions as a biopterin transporters involved in the uptake and the secretion of coenzymes tetrahydrobiopterin (BH4), dihydrobiopterin (BH2) and sepiapterin to urine, thereby determining baseline levels of blood biopterins (By similarity). May be involved in the basolateral transport of steviol, a metabolite of the popular sugar substitute stevioside (By similarity). May participate in the detoxification/ renal excretion of drugs and xenobiotics, such as the histamine H(2)-receptor antagonists fexofenadine and cimetidine, the antibiotic benzylpenicillin (PCG), the anionic herbicide 2,4-dichloro-phenoxyacetate (2,4-D), the diagnostic agent p-aminohippurate (PAH), the antiviral acyclovir (ACV), and the mycotoxin ochratoxin (OTA), by transporting these exogenous organic anions across the cell membrane in exchange for dicarboxylates such as 2-oxoglutarate (By similarity). Contributes to the renal uptake of potent uremic toxins (indoxyl sulfate (IS), indole acetate (IA), hippurate/N-benzoylglycine (HA) and 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF)), pravastatin, PCG, E1S and dehydroepiandrosterone sulfate (DHEAS), and is partly involved in the renal uptake of temocaprilat (an angiotensin-converting enzyme (ACE) inhibitor) (PubMed:11861777, PubMed:12660303, PubMed:14675047, PubMed:15846470). May contribute to the release of cortisol in the adrenals (By similarity). Involved in one of the detoxification systems on the choroid plexus (CP), removes substrates such as E1S or taurocholate (TC), PCG, 2,4-D and PAH, from the cerebrospinal fluid (CSF) to the blood for eventual excretion in urine and bile (PubMed:11961115, PubMed:15319347, PubMed:15389674). Regulates the CSF concentration of histamine H(2)-receptor antagonists cimetidine and ranitidine at the CP (PubMed:15319347). Also contributes to the uptake of several other organic compounds such as the prostanoids prostaglandin E(2) and prostaglandin F(2-alpha), L-carnitine, and the therapeutic drugs allopurinol, 6-mercaptopurine (6-MP) and 5-fluorouracil (5-FU) (By similarity). Mediates the uptake from brain of organic anions, such as E1S, PAH, and OTA (PubMed:10224140, PubMed:11961115). Mediates the transport of PAH, PCG, and the statins pravastatin and pitavastatin, from the cerebrum into the blood circulation across the blood-brain barrier (BBB) (PubMed:11961115, PubMed:12684544, PubMed:15292460). In summary, plays a role in the efflux of drugs and xenobiotics, helping reduce their undesired toxicological effects on the body (PubMed:15292460)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Gut-derived uremic toxin handling in vivo requires OAT-mediated tubular secretion in chronic kidney disease. Publication Status: Online-Only, [RefSeq, PubMed]; Hypouricemic agents reduce indoxyl sulfate excretion by inhibiting the renal transporters OAT1/3 and ABCG2. Publication Status: Online-Only, [RefSeq, PubMed]; Role of aromatic transmembrane residues in substrate recognition, [RefSeq, PubMed]; Study results indicate that Oat1 and Oat3 at the blood-arachnoid barrier provide a distinct clearance pathway of organic anion drugs from cerebrospinal fluid independently of choroid plexus., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q66HN0", "ec_number_list": [], "go_molecular_function": "GO:0015651 quaternary ammonium group transmembrane transporter activity;GO:0042910 xenobiotic transmembrane transporter activity;GO:0022857 transmembrane transporter activity;GO:0005080 protein kinase C binding;GO:0015297 antiporter activity", "go_cellular_component": "GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0012505 endomembrane system;GO:0016020 membrane;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0015697 quaternary ammonium group transport;GO:0034635 glutathione transport;GO:0006811 monoatomic ion transport;GO:0009636 response to toxic substance;GO:0015711 organic anion transport", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q9R1U7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40748-1", "uniprot_id": [ { "id": "SYT3_RAT", "url": "https://www.uniprot.org/uniprot/P40748", "type": "external" } ], "mass": 63313.0, "length": 588, "protein_name": "Synaptotagmin-3", "gene_name": "Syt3", "organism": "Rat", "refseq_name": "synaptotagmin-3", "refseq_ac": [ { "id": "NP_061995", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061995", "type": "external" } ], "gene_names_uniprotkb": "Syt3", "gene_names_refseq": "SIII; Syt3", "protein_names_uniprotkb": "Synaptotagmin-3; Synaptotagmin III; SytIII", "protein_names_refseq": "synaptotagmin III; synaptotagmin-3; sytIII", "tax_id": 10116, "disease": "", "pathway": " (rno:25731)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10545502;11823420;18508778;20173762;8163462", "class_list": "", "function": "Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain. Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (PubMed:11823420, PubMed:18508778). Plays a role in dendrite formation by melanocytes (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q925B7", "ec_number_list": [], "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0030658 transport vesicle membrane;GO:0098794 postsynapse;GO:0097060 synaptic membrane", "go_biological_process": "GO:1903861 positive regulation of dendrite extension;GO:0030154 cell differentiation;GO:0051592 response to calcium ion;GO:0007268 chemical synaptic transmission;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P40748-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2TL32-1", "uniprot_id": [ { "id": "UBR4_RAT", "url": "https://www.uniprot.org/uniprot/Q2TL32", "type": "external" } ], "mass": 573792.0, "length": 5194, "protein_name": "E3 ubiquitin-protein ligase UBR4", "gene_name": "Ubr4", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ubr4; Rbaf600; Zubr1", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase UBR4; 2.3.2.27; N-recognin-4; Zinc finger UBR1-type protein 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (R-RNO-6798695); (R-RNO-983168)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "16641100;22673903;29393594", "class_list": "", "function": "E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm (By similarity). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (By similarity). Does not ubiquitinate proteins that are acetylated at the N-terminus (By similarity). Together with UBR5, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR4 probably synthesizes mixed chains containing multiple linkages, while UBR5 is likely branching multiple 'Lys-48'-linked chains of substrates initially modified (By similarity). Together with KCMF1, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (By similarity). Catalytic component of the silencing factor of the integrated stress response (SIFI) complex, a multiprotein complex that turns off the mitochondrial stress response after a specific stress event has been resolved (By similarity). The SIFI complex ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors such as ABHD10 (By similarity). Within the SIFI complex, UBR4 initiates ubiquitin chains that are further elongated or branched by KCMF1 (By similarity). Mediates ubiquitination of ACLY, leading to its subsequent degradation (By similarity). Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5BJM4", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.29", "type": "external" }, { "id": "3.4.16.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.2", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "3.4.21.73", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.73", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "1.14.19.17", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.17", "type": "external" }, { "id": "5.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.-", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.2.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.20", "type": "external" }, { "id": "2.3.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.20", "type": "external" }, { "id": "2.3.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.76", "type": "external" } ], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0045717 negative regulation of fatty acid biosynthetic process;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0050821 protein stabilization;GO:0007032 endosome organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q2TL32-1", "record_type": "protein", "filter_code": "0000000.0000111.000100.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V7P1-1", "uniprot_id": [ { "id": "STX12_RAT", "url": "https://www.uniprot.org/uniprot/G3V7P1", "type": "external" } ], "mass": 31187.0, "length": 274, "protein_name": "Syntaxin-12", "gene_name": "Stx12", "organism": "Rat", "refseq_name": "syntaxin-12", "refseq_ac": [ { "id": "NP_075228", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075228", "type": "external" } ], "gene_names_uniprotkb": "Stx12; Stx13", "gene_names_refseq": "Stx12; Syn13", "protein_names_uniprotkb": "Syntaxin-12; Syntaxin-13", "protein_names_refseq": "syntaxin-12; syntaxin-13", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162); carcinoma (Disease Ontology:DOID:305)", "pathway": " (rno:65033)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12070131;16037816;17159904;20098723;22673903;28202235;30962439;37830626;9507000;9553086", "class_list": "", "function": "SNARE promoting fusion of transport vesicles with target membranes (PubMed:17159904, PubMed:30962439). Together with SNARE STX6, promotes movement of vesicles from endosomes to the cell membrane, and may therefore function in the endocytic recycling pathway (PubMed:30962439). Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (PubMed:16037816)., [UniProtKB, PubMed, PubMed, PubMed]; SNARE promoting fusion of transport vesicles with target membranes. Together with SNARE STX6, promotes movement of vesicles from endosomes to the cell membrane, and may therefore function in the endocytic recycling pathway. Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The activation and regulation of STX12, miR-148a and SMAD5 in pancreatic stellate cells may serve as a new gene therapy strategy for the treatment of chronic pancreatitis and reversal of pancreatic fibrosis., [RefSeq, PubMed]; Unveiling Neuroprotection and Regeneration Mechanisms in Optic Nerve Injury: Insight from Neural Progenitor Cell Therapy with Focus on Vps35 and Syntaxin12. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O70319;O88385", "ec_number_list": [], "go_molecular_function": "GO:0000149 SNARE binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098837 postsynaptic recycling endosome;GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0045121 membrane raft", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0006886 intracellular protein transport;GO:0033344 cholesterol efflux;GO:0050821 protein stabilization;GO:0032456 endocytic recycling", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "G3V7P1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LMY4-1", "uniprot_id": [ { "id": "RYR1_RAT", "url": "https://www.uniprot.org/uniprot/F1LMY4", "type": "external" } ], "mass": 565483.0, "length": 5035, "protein_name": "Ryanodine receptor 1", "gene_name": "Ryr1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ryr1", "gene_names_refseq": "", "protein_names_uniprotkb": "Ryanodine receptor 1; RYR-1; RyR1; Skeletal muscle calcium release channel; Skeletal muscle ryanodine receptor; Skeletal muscle-type ryanodine receptor; Type 1 ryanodine receptor", "protein_names_refseq": "", "tax_id": 10116, "disease": "King Denborough syndrome (Disease Ontology:DOID:0080990); congenital myopathy 1B (Disease Ontology:DOID:0080991); pre-eclampsia (Disease Ontology:DOID:10591); gestational diabetes (Disease Ontology:DOID:11714); intracranial vasospasm (Disease Ontology:DOID:13100); primary pulmonary hypertension (Disease Ontology:DOID:14557); alcohol use disorder (Disease Ontology:DOID:1574); osteochondrodysplasia (Disease Ontology:DOID:2256); congenital myopathy 1A (Disease Ontology:DOID:3529); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); malignant hyperthermia (Disease Ontology:DOID:8545)", "pathway": " (rno:114207); (R-RNO-2672351); (R-RNO-5578775)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10444400;11316255;16641100;22673903;29393594", "class_list": "", "function": "Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules (PubMed:11316255). Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm (By similarity). Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O35208;Q9R1G1;Q9R272", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0002020 protease binding;GO:0005262 calcium channel activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005790 smooth endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0016020 membrane", "go_biological_process": "GO:0043931 ossification involved in bone maturation;GO:0003009 skeletal muscle contraction;GO:0006936 muscle contraction;GO:0051289 protein homotetramerization;GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "F1LMY4-1", "record_type": "protein", "filter_code": "0000000.0000111.000100.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49804-1", "uniprot_id": [ { "id": "RGS8_RAT", "url": "https://www.uniprot.org/uniprot/P49804", "type": "external" } ], "mass": 20949.0, "length": 180, "protein_name": "Regulator of G protein signaling 8", "gene_name": "Rgs8", "organism": "Rat", "refseq_name": "regulator of G-protein signaling 8", "refseq_ac": [ { "id": "NP_062217", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062217", "type": "external" } ], "gene_names_uniprotkb": "Rgs8", "gene_names_refseq": "Rgs8", "protein_names_uniprotkb": "Regulator of G protein signaling 8; RGS8", "protein_names_refseq": "regulator of G-protein signaling 8", "tax_id": 10116, "disease": "non-syndromic X-linked intellectual disability (Disease Ontology:DOID:0050776); non-syndromic X-linked intellectual disability 63 (Disease Ontology:DOID:0112050); intellectual disability (Disease Ontology:DOID:1059); Sjogren-Larsson syndrome (Disease Ontology:DOID:14501)", "pathway": " (rno:54297); (R-RNO-418594)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "11549278;12110731;12880183;13679049;19609226;22673903;8548815;9394004", "class_list": "", "function": "Alternative splicing determines inhibitory function of receptor type-specific Gq signaling., [RefSeq, PubMed]; Examination of expression of mRNA in developing cerebellum by in situ hybridization, [RefSeq, PubMed]; RGS8 protein is distributed in dendrites and cell body but not the nucleus nor axons of cerebellar Purkinje cells, suggesting protein distribution is controlled., [RefSeq, PubMed]; Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Modulates the activity of potassium channels that are activated in response to DRD2 and CHRM2 signaling., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0001965 G-protein alpha-subunit binding", "go_cellular_component": "GO:0005634 nucleus;GO:0030425 dendrite;GO:0043204 perikaryon;GO:0045202 synapse;GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0007213 G protein-coupled acetylcholine receptor signaling pathway;GO:0043547 positive regulation of GTPase activity;GO:0001975 response to amphetamine;GO:0045744 negative regulation of G protein-coupled receptor signaling pathway;GO:0060159 regulation of dopamine receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P49804-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P37199-1", "uniprot_id": [ { "id": "NU155_RAT", "url": "https://www.uniprot.org/uniprot/P37199", "type": "external" } ], "mass": 155003.0, "length": 1390, "protein_name": "Nuclear pore complex protein Nup155", "gene_name": "Nup155", "organism": "Rat", "refseq_name": "nuclear pore complex protein Nup155", "refseq_ac": [ { "id": "NP_446404", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446404", "type": "external" } ], "gene_names_uniprotkb": "Nup155", "gene_names_refseq": "Nup155", "protein_names_uniprotkb": "Nuclear pore complex protein Nup155; 155 kDa nucleoporin; Nucleoporin Nup155; P140", "protein_names_refseq": "155 kDa nucleoporin; P140; nuclear pore complex protein Nup155; nucleoporin 155kD; nucleoporin Nup155", "tax_id": 10116, "disease": "familial atrial fibrillation (Disease Ontology:DOID:0050650)", "pathway": " (rno:117021); (R-RNO-159227); (R-RNO-159230); (R-RNO-159231); (R-RNO-159236); (R-RNO-170822); (R-RNO-1855170); (R-RNO-1855196); (R-RNO-1855229); (R-RNO-191859); (R-RNO-3108214); (R-RNO-3232142); (R-RNO-3301854); (R-RNO-3371453); (R-RNO-4085377); (R-RNO-4551638); (R-RNO-4570464); (R-RNO-4615885); (R-RNO-9615933)", "pathway_count": 19, "publication_count": 3, "publication_id_list": "12438562;15703211;8458861", "class_list": "", "function": "BEMAD was used on a purified nuclear pore complex preparation to map novel sites of O-GlcNAc modification on Nup155., [RefSeq, PubMed]; Essential component of nuclear pore complex. Could be essessential for embryogenesis (By similarity). Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport., [UniProtKB, UniProtKB]; Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0031965 nuclear membrane;GO:0044611 nuclear pore inner ring;GO:0005643 nuclear pore", "go_biological_process": "GO:0006406 mRNA export from nucleus;GO:0034504 protein localization to nucleus;GO:0035196 miRNA processing;GO:0086014 atrial cardiac muscle cell action potential;GO:0006998 nuclear envelope organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P37199-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2L9-1", "uniprot_id": [ { "id": "NDRG4_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z2L9", "type": "external" } ], "mass": 38487.0, "length": 352, "protein_name": "Protein NDRG4", "gene_name": "Ndrg4", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ndrg4; Bdm1; Ndr4", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein NDRG4; Brain development-related molecule 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070)", "pathway": " (rno:64457)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10320792;14693380;16408304;22673903", "class_list": "", "function": "Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress (By similarity). May enhance growth factor-induced ERK1 and ERK2 phosphorylation, including that induced by NGF. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6XQ62;Q6XQ63;Q6XQ64;Q6XQ65;Q78ZK9;Q7TST8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016323 basolateral plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0031253 cell projection membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0008542 visual learning;GO:0010976 positive regulation of neuron projection development;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9Z2L9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JMD7-1", "uniprot_id": [ { "id": "SC5A7_RAT", "url": "https://www.uniprot.org/uniprot/Q9JMD7", "type": "external" } ], "mass": 63407.0, "length": 580, "protein_name": "High affinity choline transporter 1", "gene_name": "Slc5a7", "organism": "Rat", "refseq_name": "high affinity choline transporter 1", "refseq_ac": [ { "id": "NP_445973", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445973", "type": "external" } ], "gene_names_uniprotkb": "Slc5a7; Cht1", "gene_names_refseq": "Cht1; Slc5a7; rCHT1", "protein_names_uniprotkb": "High affinity choline transporter 1; CHT; Hemicholinium-3-sensitive choline transporter; Solute carrier family 5 member 7; rCHT1", "protein_names_refseq": "CHT; hemicholinium-3-sensitive choline transporter; high affinity choline transporter 1; solute carrier family 5 (choline transporter), member 7; solute carrier family 5 (sodium/choline cotransporter), member 7", "tax_id": 10116, "disease": "congenital myasthenic syndrome 20 (Disease Ontology:DOID:0110661); autosomal dominant distal hereditary motor neuronopathy 7 (Disease Ontology:DOID:0111199); major depressive disorder (Disease Ontology:DOID:1470); depressive disorder (Disease Ontology:DOID:1596); asthma (Disease Ontology:DOID:2841)", "pathway": " (rno:85426); (R-RNO-264642); (R-RNO-9958517)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10649566;12969261;17092608;36808325", "class_list": "", "function": "Activation of the High-Affinity Choline Transporter 1 in the Spinal Cord Relieves Stress-Induced Hyperalgesia., [RefSeq, PubMed]; High-affinity Na(+)-coupled choline transmembrane symporter (PubMed:10649566). Functions as an electrogenic, voltage-dependent transporter with variable charge/choline stoichiometry (By similarity). Choline uptake and choline-induced current is also Cl(-)-dependent where Cl(-) is likely a regulatory ion rather than cotransported ion (By similarity). Plays a critical role in acetylcholine (ACh) synthesis by taking up the substrate choline from the synaptic cleft into the presynaptic nerve terminals after neurotransmitter release (By similarity). SLC5A7/CHT1-mediated choline high-affinity transport in cholinergic neurons is the rate-limiting step for production of ACh, thereby facilitating communication by subsequent action potentials (By similarity). Localized predominantly in presynaptic terminal intracellular organelles, and translocated to the plasma membrane in active form in response to neuronal activity (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; High-affinity Na(+)-coupled choline transmembrane symporter. Functions as an electrogenic, voltage-dependent transporter with variable charge/choline stoichiometry. Choline uptake and choline-induced current is also Cl(-)-dependent where Cl(-) is likely a regulatory ion rather than cotransported ion. Plays a critical role in acetylcholine (ACh) synthesis by taking up the substrate choline from the synaptic cleft into the presynaptic nerve terminals after neurotransmitter release. SLC5A7/CHT1-mediated choline high-affinity transport in cholinergic neurons is the rate-limiting step for production of ACh, thereby facilitating communication by subsequent action potentials. Localized predominantly in presynaptic terminal intracellular organelles, and translocated to the plasma membrane in active form in response to neuronal activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0033265 choline binding;GO:0015220 choline transmembrane transporter activity;GO:0005307 choline:sodium symporter activity;GO:0015293 symporter activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0007271 synaptic transmission, cholinergic;GO:0007274 neuromuscular synaptic transmission;GO:0008292 acetylcholine biosynthetic process;GO:0015871 choline transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9JMD7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKE8-1", "uniprot_id": [ { "id": "TR110_RAT", "url": "https://www.uniprot.org/uniprot/Q9JKE8", "type": "external" } ], "mass": 38406.0, "length": 333, "protein_name": "Taste receptor type 2 member 110", "gene_name": "Tas2r110", "organism": "Rat", "refseq_name": "taste receptor type 2 member 110", "refseq_ac": [ { "id": "NP_001160149", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160149", "type": "external" } ], "gene_names_uniprotkb": "Tas2r110; Tas2r10", "gene_names_refseq": "Tas2r110", "protein_names_uniprotkb": "Taste receptor type 2 member 110; T2R10; T2R110; Taste receptor type 2 member 10", "protein_names_refseq": "T2R10; T2R110; taste receptor type 2 member 10; taste receptor type 2 member 110", "tax_id": 10116, "disease": "", "pathway": " (rno:100310875)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10761934;10761935;11696554;11854532;12139982;12581520", "class_list": "", "function": "Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q67ET8", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008527 taste receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JKE8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04143-1", "uniprot_id": [ { "id": "THRSP_RAT", "url": "https://www.uniprot.org/uniprot/P04143", "type": "external" } ], "mass": 17009.0, "length": 150, "protein_name": "Thyroid hormone-inducible hepatic protein", "gene_name": "Thrsp", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Thrsp; S14", "gene_names_refseq": "", "protein_names_uniprotkb": "Thyroid hormone-inducible hepatic protein; S14; SPOT14; Spot 14 protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "attention deficit hyperactivity disorder (Disease Ontology:DOID:1094)", "pathway": " (R-RNO-200425)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "1446647;20233797;22673903;2303455;4065033;6327713;8999918", "class_list": "", "function": "Plays a role in the regulation of lipogenesis, especially in lactating mammary gland. Important for the biosynthesis of triglycerides with medium-length fatty acid chains. May modulate lipogenesis by interacting with MID1IP1 and preventing its interaction with ACACA. May function as transcriptional coactivator. May modulate the transcription factor activity of THRB (By similarity)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q63536", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0140678 molecular function inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006629 lipid metabolic process;GO:0009617 response to bacterium;GO:0046890 regulation of lipid biosynthetic process;GO:0010866 regulation of triglyceride biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P04143-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31662-1", "uniprot_id": [ { "id": "S6A17_RAT", "url": "https://www.uniprot.org/uniprot/P31662", "type": "external" } ], "mass": 81055.0, "length": 727, "protein_name": "Sodium-dependent neutral amino acid transporter SLC6A17", "gene_name": "Slc6a17", "organism": "Rat", "refseq_name": "sodium-dependent neutral amino acid transporter SLC6A17", "refseq_ac": [ { "id": "NP_001028251", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028251", "type": "external" } ], "gene_names_uniprotkb": "Slc6a17; Ntt4; Rxt1", "gene_names_refseq": "Ntt4; Slc6a17", "protein_names_uniprotkb": "Sodium-dependent neutral amino acid transporter SLC6A17; Sodium-dependent neurotransmitter transporter NTT4; Solute carrier family 6 member 17", "protein_names_refseq": "orphan sodium- and chloride-dependent neurotransmitter transporter NTT4; sodium-dependent neurotransmitter transporter NTT4; sodium-dependent neutral amino acid transporter SLC6A17; solute carrier family 6 (neurotransmitter transporter), member 17; solute carrier family 6 (neutral amino acid transporter), member 17", "tax_id": 10116, "disease": "autosomal recessive intellectual developmental disorder 48 (Disease Ontology:DOID:0081212)", "pathway": " (rno:613226)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "16125675;18768736;19103603;19147495;22673903;23672601;8093354;8294906", "class_list": "", "function": "Expression of Slc6a17 increases ~9-fold at night in the rat pineal gland. Expression appears to be regulated by neural mechanisms involving norepinephrine and cyclic AMP signaling., [RefSeq, PubMed]; Synaptic vesicle transporter with apparent selectivity for neutral amino acids. The transport is sodium-coupled but chloride-independent, likely driven by the proton electrochemical gradient generated by vacuolar H(+)-ATPase in an overall electrogenic mechanism. May contribute to the synaptic uptake of neurotransmitter precursors in a process coupled in part to vesicle exocytosis., [UniProtKB, PubMed, PubMed]; The data of this results suggested that the B0AT3 transporter have a role in regulation of monoaminergic as well as glutamatergic synapses. Publication Status: Online-Only, [RefSeq, PubMed]; The substrate profile of the NTT4/XT1-dependent activity is similar to that of the closely related B(0)AT2/SBAT1 (SLC6A15), including a submillimolar apparent affinity for proline and leucine and a low millimolar apparent affinity for glutamine., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015293 symporter activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0045202 synapse", "go_biological_process": "GO:0015816 glycine transport;GO:0015820 L-leucine transport;GO:0015824 proline transport;GO:0032328 alanine transport;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P31662-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32551-1", "uniprot_id": [ { "id": "QCR2_RAT", "url": "https://www.uniprot.org/uniprot/P32551", "type": "external" } ], "mass": 48396.0, "length": 452, "protein_name": "Cytochrome b-c1 complex subunit 2, mitochondrial", "gene_name": "Uqcrc2", "organism": "Rat", "refseq_name": "cytochrome b-c1 complex subunit 2, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001006971", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006971", "type": "external" } ], "gene_names_uniprotkb": "Uqcrc2", "gene_names_refseq": "Uqcrc2", "protein_names_uniprotkb": "Cytochrome b-c1 complex subunit 2, mitochondrial; Complex III subunit 2; Core protein II; Ubiquinol-cytochrome-c reductase complex core protein 2", "protein_names_refseq": "complex III subunit 2; core protein II; cytochrome b-c1 complex subunit 2, mitochondrial precursor; cytochrome b-c1 complex subunit 2, mitochondrial; ubiquinol-cytochrome C reductase complex core protein 2, mitochondrial precursor (Complex III subunit II); ubiquinol-cytochrome c reductase core protein II; ubiquinol-cytochrome-c reductase complex core protein 2", "tax_id": 10116, "disease": "chromosome 16p12.1 deletion syndrome (Disease Ontology:DOID:0060399); mitochondrial complex III deficiency nuclear type 5 (Disease Ontology:DOID:0080114)", "pathway": " (rno:293448); (R-RNO-611105); (R-RNO-9837999); (R-RNO-9865881)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "19423663;2162168;22673903;26446791;27213235;27914013;34502162;38843836", "class_list": "", "function": "Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (By similarity). The 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2 are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively, and they seem to have preserved their MPP processing properties. May be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS)/subunit 9 when incorporated into complex III (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Proteomic analysis revealed that the expression levels of two mitochondrial proteins, cytochrome bc1 complex2 (UQCRC2, the major component of electron transport chain complex III) and aconitase (an enzyme involved in the tricarboxylic acid cycle), were decreased by homocysteine in neural stem cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q5XIR3", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045275 respiratory chain complex III", "go_biological_process": "GO:0006508 proteolysis;GO:0009410 response to xenobiotic stimulus;GO:0022904 respiratory electron transport chain", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P32551-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P37089-1", "uniprot_id": [ { "id": "SCNNA_RAT", "url": "https://www.uniprot.org/uniprot/P37089", "type": "external" } ], "mass": 78888.0, "length": 698, "protein_name": "Epithelial sodium channel subunit alpha", "gene_name": "Scnn1a", "organism": "Rat", "refseq_name": "epithelial sodium channel subunit alpha", "refseq_ac": [ { "id": "NP_113736", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113736", "type": "external" } ], "gene_names_uniprotkb": "Scnn1a; RCNaCh1; RCNaCh; Renac", "gene_names_refseq": "ENaCA; Scnn1a", "protein_names_uniprotkb": "Epithelial sodium channel subunit alpha; Alpha-ENaC; Alpha-NaCH; Amiloride-sensitive sodium channel subunit alpha; Epithelial Na(+) channel subunit alpha; Nonvoltage-gated sodium channel 1 subunit alpha; SCNEA", "protein_names_refseq": "SCNEA; alpha-ENaC; alpha-NaCH; amiloride-sensitive epithelial sodium channel alpha subunit; amiloride-sensitive sodium channel subunit alpha; epithelial Na(+) channel subunit alpha; epithelial sodium channel alpha subunit; epithelial sodium channel subunit alpha; nonvoltage-gated sodium channel 1 subunit alpha; sodium channel epithelial 1 alpha subunit; sodium channel, non-voltage-gated 1 alpha subunit; sodium channel, nonvoltage-gated 1 alpha; sodium channel, nonvoltage-gated, type I, alpha", "tax_id": 10116, "disease": "Liddle syndrome (Disease Ontology:DOID:0050477); stroke (Disease Ontology:DOID:0051061); bronchiectasis 2 (Disease Ontology:DOID:0080527); nephrotic syndrome (Disease Ontology:DOID:1184); newborn respiratory distress syndrome (Disease Ontology:DOID:12716); neurodegenerative disease (Disease Ontology:DOID:1289); hypokalemic periodic paralysis (Disease Ontology:DOID:14452); cystic fibrosis (Disease Ontology:DOID:1485); ischemia (Disease Ontology:DOID:326); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); pseudohypoaldosteronism (Disease Ontology:DOID:4479); neuroblastoma (Disease Ontology:DOID:769)", "pathway": " (rno:25122); (R-RNO-2672351); (R-RNO-9730628)", "pathway_count": 3, "publication_count": 21, "publication_id_list": "10226074;11323714;11352848;11773057;12424229;12654927;14556380;28218740;29453757;30977984;31113930;7744818;7929098;8175716;8188647;8381523;8382172;8665844;9039092;9118951;9351815", "class_list": "", "function": "Studied the effect and underlining mechanisms of MaR1(maresin 1) in modulating alveolar fluid clearance on LPS-induced acute lung injury; found MaR1 improved epithelial sodium channel (ENaC) and Na,K-adenosine triphosphatase expression and activity., [RefSeq, PubMed]; Taken together, these findings indicate that the alphaENaC 3'UTR plays an important role in modulating transcript levels, and Dhx36 and Tial1 seem to be involved in posttranscriptional regulation of alphaENaC expression in alveolar epithelial cells., [RefSeq, PubMed]; The results demonstrated that the loss of estrogen elevated systolic blood pressure in ovariectomized (OVX) rats. OVX rat kidneys showed increased alpha-ENaC expression but decreased derlin-1 expression. Publication Status: Online-Only, [RefSeq, PubMed]; This is one of the three pore-forming subunits of the heterotrimeric epithelial sodium channel (ENaC), a critical regulator of sodium balance and fluid homeostasis (PubMed:8188647, PubMed:9118951). ENaC operates in epithelial tissues, where it mediates the electrodiffusion of sodium ions from extracellular fluid through the apical membrane of cells, with water following osmotically (PubMed:8382172, PubMed:9118951). It plays a key role in maintaining sodium homeostasis through electrogenic sodium reabsorption in the kidneys. Additionally, ENaC is essential for airway surface liquid homeostasis, which is crucial for proper mucus clearance (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q64593;Q9QUI4", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0003779 actin binding;GO:0050699 WW domain binding;GO:0015280 ligand-gated sodium channel activity;GO:0005272 sodium channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0031514 motile cilium", "go_biological_process": "GO:0008217 regulation of blood pressure;GO:1904117 cellular response to vasopressin;GO:0006883 intracellular sodium ion homeostasis;GO:0035725 sodium ion transmembrane transport;GO:1904045 cellular response to aldosterone", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P37089-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1HAQ0-1", "uniprot_id": [ { "id": "PCAT1_RAT", "url": "https://www.uniprot.org/uniprot/Q1HAQ0", "type": "external" } ], "mass": 59762.0, "length": 534, "protein_name": "Lysophosphatidylcholine acyltransferase 1", "gene_name": "Lpcat1", "organism": "Rat", "refseq_name": "lysophosphatidylcholine acyltransferase 1", "refseq_ac": [ { "id": "NP_001094205", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094205", "type": "external" } ], "gene_names_uniprotkb": "Lpcat1; Aytl2", "gene_names_refseq": "Aytl2; Lpcat1; RGD1311599", "protein_names_uniprotkb": "Lysophosphatidylcholine acyltransferase 1; 1-acylglycerol-3-phosphate O-acyltransferase; 1-acylglycerophosphocholine O-acyltransferase; 1-alkenylglycerophosphocholine O-acyltransferase; 1-alkylglycerophosphocholine O-acetyltransferase; 2.3.1.23; 2.3.1.25; 2.3.1.51; 2.3.1.67; Acetyl-CoA:lyso-PAF acetyltransferase; Acetyl-CoA:lyso-platelet-activating factor acetyltransferase; Acyltransferase-like 2; LPC acyltransferase 1; LPCAT-1; Lyso-PAF acetyltransferase; LysoPAFAT; LysoPC acyltransferase 1", "protein_names_refseq": "1-acylglycerol-3-phosphate O-acyltransferase; 1-acylglycerophosphocholine O-acyltransferase; 1-alkenylglycerophosphocholine O-acyltransferase; 1-alkylglycerophosphocholine O-acetyltransferase; LPC acyltransferase 1; LPCAT-1; acetyl-CoA:lyso-PAF acetyltransferase; acetyl-CoA:lyso-platelet-activating factor acetyltransferase; acyltransferase-like 2; lyso-PAF acetyltransferase; lysoPAFAT; lysoPC acyltransferase 1; lysophosphatidylcholine acyltransferase 1", "tax_id": 10116, "disease": "", "pathway": " (rno:361467); (R-RNO-1482788); (R-RNO-1482925); (R-RNO-1483166); (R-RNO-1483191); (R-RNO-6798695)", "pathway_count": 6, "publication_count": 4, "publication_id_list": "16704971;16864775;18285344;29393594", "class_list": "", "function": "Exhibits acyltransferase activity (PubMed:16864775). Exhibits acetyltransferase activity (By similarity). Activity is calcium-independent (By similarity). Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (PubMed:16864775). Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:16864775). Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively (By similarity). Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) (By similarity). May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology (PubMed:16864775). Involved in the regulation of lipid droplet number and size (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; LPCAT1 transfers acetate from acetyl-CoA to lyso-PAF; its activity and expression are independent of inflammatory signals, [RefSeq, PubMed]; Results suggest that lysophosphatidylcholine acyltransferase (LPCAT) plays a critical role in regulating surfactant phospholipid biosynthesis [LPCAT]., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "2.3.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.15", "type": "external" }, { "id": "3.4.16.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.2", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "2.3.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67", "type": "external" }, { "id": "2.3.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.4.23.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.-", "type": "external" }, { "id": "2.3.1.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n7", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.2.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.25", "type": "external" }, { "id": "3.5.1.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.92", "type": "external" }, { "id": "2.3.1.n6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n6", "type": "external" }, { "id": "3.2.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.20", "type": "external" } ], "go_molecular_function": "GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0042171 lysophosphatidic acid acyltransferase activity;GO:0005509 calcium ion binding;GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity;GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005811 lipid droplet;GO:0005886 plasma membrane", "go_biological_process": "GO:0043129 surfactant homeostasis;GO:0060041 retina development in camera-type eye;GO:0036151 phosphatidylcholine acyl-chain remodeling;GO:0045732 positive regulation of protein catabolic process;GO:0008654 phospholipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q1HAQ0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q569C0-1", "uniprot_id": [ { "id": "TM100_RAT", "url": "https://www.uniprot.org/uniprot/Q569C0", "type": "external" } ], "mass": 14352.0, "length": 134, "protein_name": "Transmembrane protein 100", "gene_name": "Tmem100", "organism": "Rat", "refseq_name": "transmembrane protein 100", "refseq_ac": [ { "id": "NP_001017479", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017479", "type": "external" } ], "gene_names_uniprotkb": "Tmem100", "gene_names_refseq": "Tmem100", "protein_names_uniprotkb": "Transmembrane protein 100", "protein_names_refseq": "transmembrane protein 100", "tax_id": 10116, "disease": "", "pathway": " (rno:497979)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10. Involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons. Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open probability of the TRPA1-TRPV1 complex., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0043204 perikaryon;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0001525 angiogenesis;GO:0001570 vasculogenesis;GO:0001701 in utero embryonic development;GO:0007219 Notch signaling pathway;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q569C0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RJT2-1", "uniprot_id": [ { "id": "SPB1_RAT", "url": "https://www.uniprot.org/uniprot/Q5RJT2", "type": "external" } ], "mass": 94767.0, "length": 829, "protein_name": "pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3", "gene_name": "Ftsj3", "organism": "Rat", "refseq_name": "pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3", "refseq_ac": [ { "id": "NP_001012014", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012014", "type": "external" } ], "gene_names_uniprotkb": "Ftsj3", "gene_names_refseq": "Ftsj3", "protein_names_uniprotkb": "pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3; 2.1.1.-; Protein ftsJ homolog 3; Putative rRNA methyltransferase 3", "protein_names_refseq": "2'-O-ribose RNA methyltransferase SPB1 homolog; FtsJ RNA methyltransferase homolog 3; FtsJ homolog 3; pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3; pre-rRNA processing protein FTSJ3; protein ftsJ homolog 3; putative rRNA methyltransferase 3; rRNA (uridine-2'-O-)-methyltransferase 3", "tax_id": 10116, "disease": "", "pathway": " (rno:303608); (R-RNO-6791226)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0016435 rRNA (guanine) methyltransferase activity;GO:0008650 rRNA (uridine-2'-O-)-methyltransferase activity;GO:0062105 RNA 2'-O-methyltransferase activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0030687 preribosome, large subunit precursor;GO:0030688 preribosome, small subunit precursor", "go_biological_process": "GO:0031167 rRNA methylation;GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0001510 RNA methylation;GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5RJT2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q925C0-1", "uniprot_id": [ { "id": "SYT9_RAT", "url": "https://www.uniprot.org/uniprot/Q925C0", "type": "external" } ], "mass": 56233.0, "length": 491, "protein_name": "Synaptotagmin-9", "gene_name": "Syt9", "organism": "Rat", "refseq_name": "synaptotagmin-9", "refseq_ac": [ { "id": "NP_445776", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445776", "type": "external" } ], "gene_names_uniprotkb": "Syt9; Syt5", "gene_names_refseq": "Syt9; Sytv", "protein_names_uniprotkb": "Synaptotagmin-9; Synaptotagmin 5; Synaptotagmin IX; Synaptotagmin V; SytIX", "protein_names_refseq": "synaptogamin V; synaptotagmin 5; synaptotagmin IX; synaptotagmin V; synaptotagmin-9; sytIX", "tax_id": 10116, "disease": "", "pathway": " (rno:60564); (R-RNO-8856825); (R-RNO-8856828)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "11823420;20573977;21287204;22673903;26202512;7791877", "class_list": "", "function": "Data show that Syt I produced more rapid dilation of fusion pores than syt VII or syt IX, consistent with its role in synchronous synaptic release., [RefSeq, PubMed]; In contrast to PC12 cells and the pancreatic beta cell line INS-1, Syt9 was not immunodetected in large dense-core vesicles in rat chromaffin cells., [RefSeq, PubMed]; May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis., [UniProtKB]; Syt-9 regulates endogenous APP-CTF and Abeta levels in PC12 cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q62748", "ec_number_list": [], "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0005544 calcium-dependent phospholipid binding;GO:0000149 SNARE binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030141 secretory granule;GO:0030672 synaptic vesicle membrane;GO:0070382 exocytic vesicle;GO:0031045 dense core granule", "go_biological_process": "GO:0007268 chemical synaptic transmission;GO:0050796 regulation of insulin secretion;GO:0016192 vesicle-mediated transport;GO:0031340 positive regulation of vesicle fusion;GO:0045956 positive regulation of calcium ion-dependent exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q925C0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQ25-1", "uniprot_id": [ { "id": "S38A4_RAT", "url": "https://www.uniprot.org/uniprot/Q9EQ25", "type": "external" } ], "mass": 60613.0, "length": 547, "protein_name": "Sodium-coupled neutral amino acid transporter 4", "gene_name": "Slc38a4", "organism": "Rat", "refseq_name": "sodium-coupled neutral amino acid transporter 4", "refseq_ac": [ { "id": "NP_570104", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_570104", "type": "external" } ], "gene_names_uniprotkb": "Slc38a4; Ata3; Snat4", "gene_names_refseq": "Ata3; Slc38a4", "protein_names_uniprotkb": "Sodium-coupled neutral amino acid transporter 4; Amino acid transporter A3; Na(+)-coupled neutral amino acid transporter 4; Solute carrier family 38 member 4; System A amino acid transporter 3", "protein_names_refseq": "Na(+)-coupled neutral amino acid transporter 4; amino acid transport system A3; amino acid transporter A3; sodium-coupled neutral amino acid transporter 4; system A amino acid transporter 3", "tax_id": 10116, "disease": "", "pathway": " (rno:170573); (R-RNO-352230)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "11118514;21454685;22673903;29393594", "class_list": "", "function": "Symporter that cotransports neutral amino acids and sodium ions from the extracellular to the intracellular side of the cell membrane (PubMed:11118514). The transport is electrogenic, pH dependent and partially tolerates substitution of Na(+) by Li(+) (PubMed:11118514). Preferentially transports smaller amino acids, such as glycine, L-alanine, L-serine, L-asparagine and L-threonine, followed by L-cysteine, L-histidine, L-proline and L-glutamine and L-methionine (PubMed:11118514)., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015179 L-amino acid transmembrane transporter activity;GO:0015171 amino acid transmembrane transporter activity;GO:0005283 amino acid:sodium symporter activity;GO:0061459 L-arginine transmembrane transporter activity;GO:0005295 neutral L-amino acid:sodium symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031528 microvillus membrane", "go_biological_process": "GO:1904557 L-alanine transmembrane transport;GO:0015804 neutral amino acid transport;GO:0003333 amino acid transmembrane transport;GO:1903826 L-arginine transmembrane transport;GO:1904273 L-alanine import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9EQ25-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKC9-1", "uniprot_id": [ { "id": "SYNRG_RAT", "url": "https://www.uniprot.org/uniprot/Q9JKC9", "type": "external" } ], "mass": 141359.0, "length": 1329, "protein_name": "Synergin gamma", "gene_name": "Synrg", "organism": "Rat", "refseq_name": "synergin gamma", "refseq_ac": [ { "id": "NP_445871", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445871", "type": "external" } ], "gene_names_uniprotkb": "Synrg; Ap1gbp1; Syng", "gene_names_refseq": "Ap1gbp1; Syng; Synrg", "protein_names_uniprotkb": "Synergin gamma; AP1 subunit gamma-binding protein 1; Gamma-synergin", "protein_names_refseq": "AP1 subunit gamma-binding protein 1; gamma-synergin; synergin gamma", "tax_id": 10116, "disease": "", "pathway": " (rno:84479)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10477754;10777571;17218081;22673903", "class_list": "", "function": "Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (By similarity). May act by linking the adapter protein complex AP-1 to other proteins (By similarity). Component of clathrin-coated vesicles (By similarity). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A1EC70;A1EC72;A1EC74;A1EC75;Q9R145", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0048471 perinuclear region of cytoplasm;GO:0030130 clathrin coat of trans-Golgi network vesicle", "go_biological_process": "GO:0006897 endocytosis;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9JKC9-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z158-1", "uniprot_id": [ { "id": "STX17_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z158", "type": "external" } ], "mass": 33182.0, "length": 301, "protein_name": "Syntaxin-17", "gene_name": "Stx17", "organism": "Rat", "refseq_name": "syntaxin-17", "refseq_ac": [ { "id": "NP_663775", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663775", "type": "external" } ], "gene_names_uniprotkb": "Stx17", "gene_names_refseq": "Stx17", "protein_names_uniprotkb": "Syntaxin-17", "protein_names_refseq": "syntaxin-17", "tax_id": 10116, "disease": "", "pathway": " (rno:252853); (R-RNO-204005)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10930465;21545355;23006999;32467992;9852078", "class_list": "", "function": "Hyperoxia reduces STX17 expression and inhibits the autophagic flux in alveolar type II epithelial cells in newborn rats., [RefSeq, PubMed]; SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane. May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0000149 SNARE binding;GO:0019903 protein phosphatase binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0030897 HOPS complex;GO:0000421 autophagosome membrane;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0034497 protein localization to phagophore assembly site;GO:0006887 exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9Z158-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYP5-1", "uniprot_id": [ { "id": "CADM1_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYP5", "type": "external" } ], "mass": 51854.0, "length": 476, "protein_name": "Cell adhesion molecule 1", "gene_name": "Cadm1", "organism": "Rat", "refseq_name": "cell adhesion molecule 1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001012201", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012201", "type": "external" } ], "gene_names_uniprotkb": "Cadm1; SynCam1", "gene_names_refseq": "Cadm1; Igsf4a; Igsf4; Necl-2; SynCAM; TSLC-1; TSLC1; sgigsf", "protein_names_uniprotkb": "Cell adhesion molecule 1; SynCAM; Synaptic cell adhesion molecule; TSLC-1; Tumor suppressor in lung cancer 1 homolog", "protein_names_refseq": "cell adhesion molecule 1 isoform 1 precursor; immunoglobulin superfamily, member 4A; nectin-like protein 2; spermatogenic immunoglobulin superfamily; synaptic cell adhesion molecule; tumor suppressor in lung cancer 1 homolog", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283); breast carcinoma (Disease Ontology:DOID:3459); lung adenocarcinoma (Disease Ontology:DOID:3910); hepatocellular carcinoma (Disease Ontology:DOID:684); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991)", "pathway": " (rno:363058); (R-RNO-418990); (R-RNO-420597)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "12202822;16814249;22673903;27072493;27756895;28335740;32929607", "class_list": "", "function": "A brain-specific, immunoglobulin domain-containing protein that binds to intracellular PDZ-domain proteins and functions as a homophilic cell adhesion molecule at the synapse (SynCAM; Synaptic cell adhesion molecule), [RefSeq, PubMed]; CADM1 enhances intestinal barrier function in a rat model of mild inflammatory bowel disease by inhibiting the STAT3 signaling pathway., [RefSeq, PubMed]; Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ T-cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo (By similarity). In mast cells, may mediate attachment to and promote communication with nerves (By similarity). CADM1, together with MITF, is essential for development and survival of mast cells in vivo. By interacting with CRTAM and thus promoting the adhesion between CD8+ T-cells and CD8+ dendritic cells, regulates the retention of activated CD8+ T-cell within the draining lymph node. Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells. Interaction with CRTAM promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells. Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; MiR-21 overexpression promotes cardiac fibrosis via STAT3 signaling pathway by decrease CADM1 expression, indicating miR-21 as an important signaling molecule for cardiac fibrotic remodeling and atrial fibrillation. Publication Status: Online-Only, [RefSeq, PubMed]; Our results suggest that, as in the CNS, CADM1 interactions drive exocytic site assembly and promote actin network formation. These results support the broader hypothesis that the effects of cell-cell contact on beta-cell maturation and function are mediated by the same extracellular protein interactions that drive the formation of the presynaptic exocytic machinery. These interactions may be therapeutic targets for re..., [RefSeq, PubMed]; Proteins. Our results highlight a previously unexplored role for MPP2 at postsynaptic sites as a scaffold that links SynCAM1 cell adhesion molecules to core proteins of the postsynaptic density. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "F7EYW4;Q0WXX6", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0050839 cell adhesion molecule binding;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0014069 postsynaptic density;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0099054 presynapse assembly;GO:0098942 retrograde trans-synaptic signaling by trans-synaptic protein complex;GO:0001889 liver development;GO:0007155 cell adhesion;GO:0001933 negative regulation of protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6AYP5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q00954-1", "uniprot_id": [ { "id": "SCN1B_RAT", "url": "https://www.uniprot.org/uniprot/Q00954", "type": "external" } ], "mass": 24692.0, "length": 218, "protein_name": "Sodium channel regulatory subunit beta-1", "gene_name": "Scn1b", "organism": "Rat", "refseq_name": "sodium channel regulatory subunit beta-1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001257974", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257974", "type": "external" } ], "gene_names_uniprotkb": "Scn1b", "gene_names_refseq": "Scn1b", "protein_names_uniprotkb": "Sodium channel regulatory subunit beta-1", "protein_names_refseq": "sodium channel regulatory subunit beta-1 isoform 1 precursor; sodium channel regulatory subunit beta-1; sodium channel subunit beta-1; sodium channel, voltage-gated, type 1, beta polypeptide; sodium channel, voltage-gated, type I, beta polypeptide; sodium channel, voltage-gated, type I, beta subunit", "tax_id": 10116, "disease": "familial atrial fibrillation (Disease Ontology:DOID:0050650); generalized epilepsy with febrile seizures plus (Disease Ontology:DOID:0060170); developmental and epileptic encephalopathy 52 (Disease Ontology:DOID:0080455); Brugada syndrome 5 (Disease Ontology:DOID:0110222); generalized epilepsy with febrile seizures plus 1 (Disease Ontology:DOID:0111302); alcohol use disorder (Disease Ontology:DOID:1574); porokeratosis (Disease Ontology:DOID:3805); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:29686)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11470829;1375395;15178439;22425777;24090084;26528804;28012039;28758202;36541246;8021275;8282123", "class_list": "", "function": "Nav1.1 and Nav1.2 are highly expressed in axon terminals in central hilus compared to stratum radiatum and in dendrites and spines in stratum radiatum compared to central hilus, [RefSeq, PubMed]; Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. The accessory beta subunits participate in localization and functional modulation of the Nav channels. Modulates the activity of SCN1A/Nav1.1, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN4A/Nav1.4, SCN5A/Nav1.5, SCN8A/Nav1.6, SCN9A/Nav1.7 and SCN10A/Nav1.8., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; The presences of Nav1.1, Nav1.6, Navbeta1 and Navbeta3 mRNA and their reduced levels in rat SAN during aging., [RefSeq, PubMed]; The relationship between miRNA-210 and SCN1B in fetal rats with hypoxic-ischemic brain injury., [RefSeq, PubMed]; The role of the intracellular IFM motif of rNav1.4 (skeletal muscle isoform of the rat Na(+) channel) on the alpha-beta1 functional interaction, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 8, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q505J0", "ec_number_list": [], "go_molecular_function": "GO:0019871 sodium channel inhibitor activity;GO:0017080 sodium channel regulator activity;GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043204 perikaryon;GO:0014704 intercalated disc;GO:0030315 T-tubule;GO:0033268 node of Ranvier", "go_biological_process": "GO:0010976 positive regulation of neuron projection development;GO:0051899 membrane depolarization;GO:0086010 membrane depolarization during action potential;GO:0086091 regulation of heart rate by cardiac conduction;GO:0002028 regulation of sodium ion transport", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q00954-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04775-1", "uniprot_id": [ { "id": "SCN2A_RAT", "url": "https://www.uniprot.org/uniprot/P04775", "type": "external" } ], "mass": 227874.0, "length": 2005, "protein_name": "Sodium channel protein type 2 subunit alpha", "gene_name": "Scn2a", "organism": "Rat", "refseq_name": "sodium channel protein type 2 subunit alpha", "refseq_ac": [ { "id": "NP_036779", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036779", "type": "external" } ], "gene_names_uniprotkb": "Scn2a; Scn2a1", "gene_names_refseq": "NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN; Scn2a1; Scn2a2; Scn2a; ScpII", "protein_names_uniprotkb": "Sodium channel protein type 2 subunit alpha; Sodium channel protein brain II subunit alpha; Sodium channel protein type II subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.2", "protein_names_refseq": "RIIA sodium channel protein; sodium channel protein type 2 subunit alpha; sodium channel protein type II subunit alpha; sodium channel protein, brain II subunit alpha; sodium channel voltage-gated type II alpha polypeptide; sodium channel, voltage-gated, type 2, alpha 1 polypeptide; sodium channel, voltage-gated, type 2, alpha 1 subunit; sodium channel, voltage-gated, type II, alpha 1; sodium channel, voltage-gated, type II, alpha subunit; voltage-gated sodium channel subunit alpha Nav1.2", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); generalized epilepsy with febrile seizures plus (Disease Ontology:DOID:0060170); episodic ataxia type 9 (Disease Ontology:DOID:0060965); developmental and epileptic encephalopathy 11 (Disease Ontology:DOID:0080421); Dravet syndrome (Disease Ontology:DOID:0080422); benign familial infantile seizures 3 (Disease Ontology:DOID:0081116); generalized epilepsy with febrile seizures plus 2 (Disease Ontology:DOID:0111294); epilepsy (Disease Ontology:DOID:1826); anxiety disorder (Disease Ontology:DOID:2030)", "pathway": " (rno:24766)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "10827969;11166117;1322892;15548568;1658937;16641100;20131913;20678086;21439835;22673903;24297919;24497506;26039939;26894959;28029095;28343066;28758202;28916793;33051988;3754035;9893979", "class_list": "", "function": "Knockdown of Nav1.2 channels in pre-oligodendrocyte alters their morphology, reduces axon-oligodendrocyte interactions and impairs myelination. Publication Status: Online-Only, [RefSeq, PubMed]; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed, UniProtKB]; Scorpion toxin MeuNaTxalpha-1 sensitizes primary nociceptors by selective modulation of voltage-gated sodium channels., [RefSeq, PubMed]; The Nav1.2 are highly expressed in axon terminals in central hilus compared to stratum radiatum and in dendrites and spines in stratum radiatum compared to central hilus ., [RefSeq, PubMed]; The polarity of (Ca(2+))2-CaMC relative to the IQ motif of NaV1.2 was opposite to that seen in apo CaMC-Nav1.2IQp (2KXW), revealing that CaMC recognizes nested, anti-parallel sites in Nav1.2IQp. (CaMC is C-domain residues of CaM, calmodulin)., [RefSeq, PubMed]; Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with four repeat domains, each of which is composed of six membrane-spanning segments, and one or more regulatory beta subunits. Voltage-gated sodium channels are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. In humans, variants of this gene are associated with seizure disorders and autism spectrum disorder. Mice homozygous for a knockout mutation die with severe hypoxia and extensive neuronal cell death, while gain of function mutations result in progressive seizure disorder. [provided by RefSeq, Nov 2016]., [RefSeq]", "predicted_glycosites": 10, "predicted_n_glycosites": 10, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 24, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0043522 leucine zipper domain binding;GO:0005248 voltage-gated sodium channel activity;GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0014704 intercalated disc", "go_biological_process": "GO:0007399 nervous system development;GO:0007613 memory;GO:0019228 neuronal action potential;GO:0051402 neuron apoptotic process;GO:0019233 sensory perception of pain", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P04775-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4QQS1-1", "uniprot_id": [ { "id": "T184A_RAT", "url": "https://www.uniprot.org/uniprot/Q4QQS1", "type": "external" } ], "mass": 46878.0, "length": 425, "protein_name": "Transmembrane protein 184A", "gene_name": "Tmem184a", "organism": "Rat", "refseq_name": "transmembrane protein 184A", "refseq_ac": [ { "id": "NP_001020584", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020584", "type": "external" } ], "gene_names_uniprotkb": "Tmem184a", "gene_names_refseq": "RGD1306702; Tmem184a", "protein_names_uniprotkb": "Transmembrane protein 184A", "protein_names_refseq": "transmembrane protein 184A", "tax_id": 10116, "disease": "", "pathway": " (rno:304325)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "26769966", "class_list": "", "function": "Acts as a heparin receptor in vascular cells (PubMed:26769966). May be involved in vesicle transport in exocrine cells and Sertoli cells (By similarity)., [UniProtKB, PubMed, UniProtKB]; TMEM184A is a heparin receptor in vascular cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5XHY9", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0030658 transport vesicle membrane;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0032880 regulation of protein localization;GO:0051046 regulation of secretion;GO:0018992 germ-line sex determination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4QQS1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62868-1", "uniprot_id": [ { "id": "ROCK2_RAT", "url": "https://www.uniprot.org/uniprot/Q62868", "type": "external" } ], "mass": 160387.0, "length": 1388, "protein_name": "Rho-associated protein kinase 2", "gene_name": "Rock2", "organism": "Rat", "refseq_name": "rho-associated protein kinase 2", "refseq_ac": [ { "id": "NP_037154", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037154", "type": "external" } ], "gene_names_uniprotkb": "Rock2", "gene_names_refseq": "ROCK-II; ROK; Rock2", "protein_names_uniprotkb": "Rho-associated protein kinase 2; 2.7.11.39; ROCK-II; ROKalpha; Rho-associated, coiled-coil-containing protein kinase 2; Rho-associated, coiled-coil-containing protein kinase II; RhoA-binding kinase 2; p150 ROK-alpha; p164 ROCK-2", "protein_names_refseq": "ROKalpha; Rho-associated coiled-coil forming kinase 2; RhoA - binding serine/threosine kinase alpha (ROK - alpha); p150 ROK-alpha; p164 ROCK-2; rho-associated protein kinase 2; rho-associated, coiled-coil-containing protein kinase 2; rho-associated, coiled-coil-containing protein kinase II; rhoA-binding kinase 2", "tax_id": 10116, "disease": "primary biliary cholangitis (Disease Ontology:DOID:12236); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (rno:25537); (R-RNO-3928662); (R-RNO-416482); (R-RNO-416572); (R-RNO-4420097); (R-RNO-5627117); (R-RNO-8980692); (R-RNO-9013026); (R-RNO-9013106); (R-RNO-9013407); (R-RNO-9013422)", "pathway_count": 11, "publication_count": 16, "publication_id_list": "11739394;11867620;15699075;15753127;19099536;19131646;21457715;32308124;32386193;32485129;32813542;35889443;37096660;7493923;8816443;9353125", "class_list": "", "function": "3-Mercaptopyruvate sulfurtransferase/hydrogen sulfide protects cerebral endothelial cells against oxygen-glucose deprivation/reoxygenation-induced injury via mitoprotection and inhibition of the RhoA/ROCK pathway., [RefSeq, PubMed]; CircHECTD1 promoted MIRI-associated inflammation via inhibiting miR-138-5p and upregulating ROCK2., [RefSeq, PubMed]; Ghrelin suppresses migration of macrophages via inhibition of ROCK2 under chronic intermittent hypoxia., [RefSeq, PubMed]; Glucagon-like peptide 1 reverses myocardial hypertrophy through cAMP/PKA/RhoA/ROCK2 signaling., [RefSeq, PubMed]; Increased ROCK1 not ROCK2 in circulating leukocytes in rats with myocardial ischemia/reperfusion., [RefSeq, PubMed]; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity., [UniProtKB, UniProtKB, UniProtKB]; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays a role in placental homeostasis during the perinatal period. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; RhoA and Rho kinase-dependent phosphorylation of moesin at Thr-558 in hippocampal neuronal cells by glutamate, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.13", "type": "external" } ], "go_molecular_function": "GO:0072518 Rho-dependent protein serine/threonine kinase activity;GO:0002020 protease binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0032723 positive regulation of connective tissue growth factor production;GO:0071559 response to transforming growth factor beta;GO:1902966 positive regulation of protein localization to early endosome;GO:1905205 positive regulation of connective tissue replacement;GO:1903140 regulation of establishment of endothelial barrier", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q62868-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z270-1", "uniprot_id": [ { "id": "VAPA_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z270", "type": "external" } ], "mass": 27841.0, "length": 249, "protein_name": "Vesicle-associated membrane protein-associated protein A", "gene_name": "Vapa", "organism": "Rat", "refseq_name": "vesicle-associated membrane protein-associated protein A", "refseq_ac": [ { "id": "NP_113819", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113819", "type": "external" } ], "gene_names_uniprotkb": "Vapa; Vap33", "gene_names_refseq": "Vapa", "protein_names_uniprotkb": "Vesicle-associated membrane protein-associated protein A; 33 kDa VAMP-associated protein; VAMP-A; VAMP-associated protein A; VAP-33; VAP-A", "protein_names_refseq": "33 kDa Vamp-associated protein; VAMP (vesicle-associated membrane protein)-associated protein A; VAMP-A; VAP-33; VAP-A; vesicle-associated membrane protein, associated protein a; vesicle-associated membrane protein-associated protein A", "tax_id": 10116, "disease": "amyotrophic lateral sclerosis type 8 (Disease Ontology:DOID:0050752); autosomal dominant adult-onset proximal spinal muscular atrophy (Disease Ontology:DOID:0111194); neurodegenerative disease (Disease Ontology:DOID:1289); motor neuron disease (Disease Ontology:DOID:231); amyotrophic lateral sclerosis (Disease Ontology:DOID:332)", "pathway": " (rno:58857); (R-RNO-6798695); (R-RNO-9609523)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "15240697;16004875;19289470;22673903;24262037;31594761;9920726", "class_list": "", "function": "Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44. STARD3-VAPA interaction enables cholesterol transfer from the ER to endosomes. Via interaction with WDR44 participates in neosynthesized protein export. In addition, recruited to the plasma membrane through OSBPL3 binding. The OSBPL3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology (By similarity). May play a role in vesicle trafficking (PubMed:19289470)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; MicroRNA-15a Inhibits Glucose Transporter 4 Translocation and Impairs Glucose Metabolism in L6 Skeletal Muscle Via Targeting of Vesicle-Associated Membrane Protein-Associated Protein A., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P723", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0019904 protein domain specific binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0016020 membrane", "go_biological_process": "GO:0006686 sphingomyelin biosynthetic process;GO:0044829 host-mediated activation of viral genome replication;GO:0031175 neuron projection development;GO:0035627 ceramide transport;GO:0015914 phospholipid transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9Z270-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7VJC2-1", "uniprot_id": [ { "id": "ROA2_RAT", "url": "https://www.uniprot.org/uniprot/A7VJC2", "type": "external" } ], "mass": 37478.0, "length": 353, "protein_name": "Heterogeneous nuclear ribonucleoproteins A2/B1", "gene_name": "Hnrnpa2b1", "organism": "Rat", "refseq_name": "heterogeneous nuclear ribonucleoproteins A2/B1", "refseq_ac": [ { "id": "NP_001098083", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098083", "type": "external" } ], "gene_names_uniprotkb": "Hnrnpa2b1; Hnrnp; Hnrpa2b1", "gene_names_refseq": "Hnrnpa2b1; Hnrpa2b1; Hnrpa2; hnRNP", "protein_names_uniprotkb": "Heterogeneous nuclear ribonucleoproteins A2/B1; hnRNP A2/B1", "protein_names_refseq": "heterogeneous nuclear ribonucleoprotein A2; heterogeneous nuclear ribonucleoprotein B0a; heterogeneous nuclear ribonucleoprotein B0b; heterogeneous nuclear ribonucleoprotein B1; heterogeneous nuclear ribonucleoproteins A2/B1; hnRNP A2 / hnRNP B1; hnRNP A2/B1; nuclear ribonucleoprotein particle A2 protein", "tax_id": 10116, "disease": "inclusion body myopathy with Paget disease of bone and frontotemporal dementia (Disease Ontology:DOID:0050881); inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 2 (Disease Ontology:DOID:0111384); Alzheimer's disease (Disease Ontology:DOID:10652); neurodegenerative disease (Disease Ontology:DOID:1289); transient cerebral ischemia (Disease Ontology:DOID:224); lung non-small cell carcinoma (Disease Ontology:DOID:3908); pancreatic carcinoma (Disease Ontology:DOID:4905); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148)", "pathway": " (rno:362361); (R-RNO-72163); (R-RNO-72203); (R-RNO-9770562)", "pathway_count": 4, "publication_count": 17, "publication_id_list": "10567417;10772824;15659580;18683930;19099192;19343716;20406423;22673903;24098712;25124043;25286195;26663205;34502162;38843836;38955308;9578590;9925756", "class_list": "", "function": "Data suggest that a prominent down-regulation of hnRNP-A2/B1 during hypoxia is associated with the post-transcriptional suppression of hASH1 synthesis., [RefSeq, PubMed]; Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs. Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus (PubMed:19099192). Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (PubMed:10567417, PubMed:9578590). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (PubMed:15659580). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts. Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs. Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs. Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (By similarity). Also plays a role in the activation of the innate immune response. Mechanistically, senses the presence of viral DNA in the nucleus, homodimerizes and is demethylated by JMJD6. In turn, translocates to the cytoplasm where it activates the TBK1-IRF3 pathway, leading to interferon alpha/beta production (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Lnc-HC negatively regulates cholesterol metabolism within hepatocytes through physical interaction with hnRNPA2B1. By further binding to the target messenger RNA of Cyp7a1 or Abca1, the lnc-HC-hnRNPA2B1 complex decreases expressions of the two genes that are implicated in cellular cholesterol excretion., [RefSeq, PubMed]; These results show that the distribution of hnRNP A2/B1 is regulated by BDNF. Publication Status: Online-Only, [RefSeq, PubMed]; UBE2I regulates the nuclear translocation of hnRNPA2B1 by contributing to SUMO modification in osteoarthritis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 19, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A7VJC1;A7VJC3;A7VJC4", "ec_number_list": [], "go_molecular_function": "GO:0001069 regulatory region RNA binding;GO:0097157 pre-mRNA intronic binding;GO:0098505 G-rich strand telomeric DNA binding;GO:0003723 RNA binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0014069 postsynaptic density", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006397 mRNA processing;GO:0006406 mRNA export from nucleus;GO:0030324 lung development;GO:0008584 male gonad development", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "A7VJC2-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0LPN4-1", "uniprot_id": [ { "id": "RYR2_RAT", "url": "https://www.uniprot.org/uniprot/B0LPN4", "type": "external" } ], "mass": 563184.0, "length": 4955, "protein_name": "Ryanodine receptor 2", "gene_name": "Ryr2", "organism": "Rat", "refseq_name": "ryanodine receptor 2 isoform 2", "refseq_ac": [ { "id": "NP_001177972", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001177972", "type": "external" } ], "gene_names_uniprotkb": "Ryr2", "gene_names_refseq": "RYR-2; RyR; Ryr2", "protein_names_uniprotkb": "Ryanodine receptor 2; Cardiac muscle ryanodine receptor-calcium release channel; Cardiac muscle ryanodine receptor; RYR-2; RyR2; Type 2 ryanodine receptor", "protein_names_refseq": "cardiac muscle ryanodine receptor-calcium release channel; cardiac muscle ryanodine receptor; cardiac-type ryaodine receptor; ryanodine receptor 2 isoform 2; ryanodine receptor 2, cardiac; ryanodine receptor type II; type 2 ryanodine receptor", "tax_id": 10116, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); catecholaminergic polymorphic ventricular tachycardia 1 (Disease Ontology:DOID:0060675); pre-eclampsia (Disease Ontology:DOID:10591); heart disease (Disease Ontology:DOID:114); gestational diabetes (Disease Ontology:DOID:11714); alcohol use disorder (Disease Ontology:DOID:1574); congenital myopathy 1A (Disease Ontology:DOID:3529); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); malignant hyperthermia (Disease Ontology:DOID:8545)", "pathway": " (rno:689560); (R-RNO-2672351); (R-RNO-5578775)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "18650434;18755143;20431056;20445169;20471962;22673903;30414461;35562179;36344175;38266577;38652413", "class_list": "", "function": "Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) cytosolic levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, UniProtKB]; Hippocampal dendritic spines express the RyR3 but not the RyR2 ryanodine receptor isoform., [RefSeq, PubMed]; Hyperglycemia triggers RyR2-dependent alterations of mitochondrial calcium homeostasis in response to cardiac ischemia-reperfusion: Key role of DRP1 activation., [RefSeq, PubMed]; RyR2 Stabilizer Attenuates Cardiac Hypertrophy by Downregulating TNF-alpha/NF-kappaB/NLRP3 Signaling Pathway through Inhibiting Calcineurin., [RefSeq, PubMed]; RyR2/IRBIT regulates insulin gene transcript, insulin content, and secretion in the insulinoma cell line INS-1. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D7UNT3;F1LRZ1;F1LS89", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0034236 protein kinase A catalytic subunit binding;GO:0005262 calcium channel activity;GO:0005516 calmodulin binding;GO:0019899 enzyme binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005790 smooth endoplasmic reticulum;GO:0016020 membrane;GO:0031234 extrinsic component of cytoplasmic side of plasma membrane;GO:0030017 sarcomere", "go_biological_process": "GO:0007584 response to nutrient;GO:0019722 calcium-mediated signaling;GO:0051592 response to calcium ion;GO:0051775 response to redox state;GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "B0LPN4-1", "record_type": "protein", "filter_code": "0000000.0000111.000100.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z8L7-1", "uniprot_id": [ { "id": "RRAS_RAT", "url": "https://www.uniprot.org/uniprot/D3Z8L7", "type": "external" } ], "mass": 23909.0, "length": 218, "protein_name": "Ras-related protein R-Ras", "gene_name": "Rras", "organism": "Rat", "refseq_name": "ras-related protein R-Ras", "refseq_ac": [ { "id": "NP_001101951", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101951", "type": "external" } ], "gene_names_uniprotkb": "Rras", "gene_names_refseq": "Rras; p23", "protein_names_uniprotkb": "Ras-related protein R-Ras; 3.6.5.2; p23", "protein_names_refseq": "Harvey rat sarcoma oncogene, subgroup R; Harvey rat sarcoma virus oncogene, subgroup R; RAS-related viral oncoprotein; Ras-related protein R-RAS (P23); ras-related protein R-Ras; related RAS viral (r-ras) oncogene homolog", "tax_id": 10116, "disease": "Costello syndrome (Disease Ontology:DOID:0050469); RASopathy (Disease Ontology:DOID:0080690); urinary bladder cancer (Disease Ontology:DOID:11054)", "pathway": " (rno:361568); (R-RNO-416550)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "15297673;19319189", "class_list": "", "function": "GTP-binding protein with GTPase activity, likely involved in the regulation of MAPK signaling pathway and thereby controlling multiple cellular processes (By similarity). Regulates the organization of the actin cytoskeleton (By similarity). With OSPBL3, modulates integrin beta-1 (ITGB1) activity (By similarity)., [UniProtKB, UniProtKB]; Plexin-B1 mediates Sema4D-induced repulsive axon guidance signaling by acting as a GTPase activating protein for R-Ras, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0044877 protein-containing complex binding;GO:0019003 GDP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0010595 positive regulation of endothelial cell migration;GO:0030336 negative regulation of cell migration;GO:0045766 positive regulation of angiogenesis;GO:0007265 Ras protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3Z8L7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29476-1", "uniprot_id": [ { "id": "NOS1_RAT", "url": "https://www.uniprot.org/uniprot/P29476", "type": "external" } ], "mass": 160559.0, "length": 1429, "protein_name": "Nitric oxide synthase 1", "gene_name": "Nos1", "organism": "Rat", "refseq_name": "nitric oxide synthase 1 isoform 1", "refseq_ac": [ { "id": "NP_434686", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_434686", "type": "external" } ], "gene_names_uniprotkb": "Nos1; Bnos", "gene_names_refseq": "Nos1; bNOS", "protein_names_uniprotkb": "Nitric oxide synthase 1; 1.14.13.39; Constitutive NOS; N-NOS; NC-NOS; NOS type I; Neuronal NOS; Nitric oxide synthase, brain; Peptidyl-cysteine S-nitrosylase NOS1; bNOS; nNOS", "protein_names_refseq": "N-NOS; NC-NOS; NOS type I; constitutive NOS; nNOS; neuronal NOS; nitric oxidase synthase; nitric oxide synthase 1 isoform 1; nitric oxide synthase 1, neuronal; nitric oxide synthase, brain; peptidyl-cysteine S-nitrosylase NOS1", "tax_id": 10116, "disease": "lissencephaly (Disease Ontology:DOID:0050453); cardiomyopathy (Disease Ontology:DOID:0050700); stroke (Disease Ontology:DOID:0051061); Parkinsonism (Disease Ontology:DOID:0080855); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); Alzheimer's disease (Disease Ontology:DOID:10652); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); nephrotic syndrome (Disease Ontology:DOID:1184); urethral obstruction (Disease Ontology:DOID:12577); hypertrophic pyloric stenosis (Disease Ontology:DOID:12638); alcoholic cardiomyopathy (Disease Ontology:DOID:12935); retinopathy of prematurity (Disease Ontology:DOID:13025); hepatic encephalopathy (Disease Ontology:DOID:13413); Parkinson's disease (Disease Ontology:DOID:14330); major depressive disorder (Disease Ontology:DOID:1470); cystic fibrosis (Disease Ontology:DOID:1485); renovascular hypertension (Disease Ontology:DOID:1591); depressive disorder (Disease Ontology:DOID:1596); epilepsy (Disease Ontology:DOID:1826); impotence (Disease Ontology:DOID:1875); transient cerebral ischemia (Disease Ontology:DOID:224); motor neuron disease (Disease Ontology:DOID:231); brain ischemia (Disease Ontology:DOID:2316); asthma (Disease Ontology:DOID:2841); acute kidney failure (Disease Ontology:DOID:3021); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); temporal lobe epilepsy (Disease Ontology:DOID:3328); schizophrenia (Disease Ontology:DOID:5419); congestive heart failure (Disease Ontology:DOID:6000); end stage renal disease (Disease Ontology:DOID:783); diabetic retinopathy (Disease Ontology:DOID:8947); achalasia (Disease Ontology:DOID:9164); type 2 diabetes mellitus (Disease Ontology:DOID:9352); allergic asthma (Disease Ontology:DOID:9415); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24598); (R-RNO-1222556); (R-RNO-392154); (R-RNO-5578775)", "pathway_count": 4, "publication_count": 48, "publication_id_list": "10221915;10400690;11086993;11237702;11473123;11867766;12218415;15105416;15208315;15251453;15466472;15548660;16244499;16984226;1712077;17161399;17446268;18271754;18498443;20002515;20371700;21595896;22576624;22673903;23300088;23643588;23806217;24499461;25940762;26945078;27529477;28087360;28238085;28470537;28782252;29074292;30103682;33121174;33296434;35772285;36964568;37442439;38100901;38747545;7520037;7530005;8806605;8864115", "class_list": "", "function": "Differential superoxide production in phosphorylated neuronal nitric oxide synthase mu and alpha variants., [RefSeq, PubMed]; Downregulation of Preso protects against ischemic/reperfusion-mediated neuronal injury through regulating PSD95-nNOS/YAP pathways., [RefSeq, PubMed]; Inhibition of miR-4640-5p alleviates pulmonary hypertension in chronic obstructive pulmonary disease patients by regulating nitric oxide synthase 1. Publication Status: Online-Only, [RefSeq, PubMed]; Mapping the Intersubunit Interdomain FMN-Heme Interactions in Neuronal Nitric Oxide Synthase by Targeted Quantitative Cross-Linking Mass Spectrometry., [RefSeq, PubMed]; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum., [UniProtKB, PubMed, PubMed, PubMed]; Produces nitric oxide (NO) which is a messenger molecule with diverse functions., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 37, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "P70594", "ec_number_list": [ { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "7.2.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.10", "type": "external" } ], "go_molecular_function": "GO:0004517 nitric-oxide synthase activity;GO:0046870 cadmium ion binding;GO:0005516 calmodulin binding;GO:0008270 zinc ion binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0044305 calyx of Held;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0046209 nitric oxide metabolic process;GO:0008285 negative regulation of cell population proliferation;GO:0010288 response to lead ion;GO:0018119 peptidyl-cysteine S-nitrosylation;GO:0032496 response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 5.2, "record_id": "P29476-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15390-1", "uniprot_id": [ { "id": "SCN4A_RAT", "url": "https://www.uniprot.org/uniprot/P15390", "type": "external" } ], "mass": 208867.0, "length": 1840, "protein_name": "Sodium channel protein type 4 subunit alpha", "gene_name": "Scn4a", "organism": "Rat", "refseq_name": "sodium channel protein type 4 subunit alpha", "refseq_ac": [ { "id": "NP_037310", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037310", "type": "external" } ], "gene_names_uniprotkb": "Scn4a", "gene_names_refseq": "NCHVS; Nav1.4; Scn4a; microI", "protein_names_uniprotkb": "Sodium channel protein type 4 subunit alpha; Mu-1; SkM1; Sodium channel protein skeletal muscle subunit alpha; Sodium channel protein type IV subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.4", "protein_names_refseq": "Sodium channel voltage-gated type IV alpha polypeptide; mu-1; skM1; sodium channel protein skeletal muscle subunit alpha; sodium channel protein type 4 subunit alpha; sodium channel protein type IV subunit alpha; sodium channel, voltage-gated, type 4, alpha polypeptide; sodium channel, voltage-gated, type 4, alpha subunit; sodium channel, voltage-gated, type IV, alpha polypeptide; sodium channel, voltage-gated, type IV, alpha subunit; voltage-gated sodium channel subunit alpha Nav1.4", "tax_id": 10116, "disease": "generalized epilepsy with febrile seizures plus (Disease Ontology:DOID:0060170); Dravet syndrome (Disease Ontology:DOID:0080422); congenital myopathy 22A (Disease Ontology:DOID:0081354); congenital myopathy 22B (Disease Ontology:DOID:0081355); congenital myasthenic syndrome 16 (Disease Ontology:DOID:0110682); generalized epilepsy with febrile seizures plus 2 (Disease Ontology:DOID:0111294); paramyotonia congenita of Von Eulenburg (Disease Ontology:DOID:0111538); hyperkalemic periodic paralysis (Disease Ontology:DOID:14451); hypokalemic periodic paralysis (Disease Ontology:DOID:14452); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (rno:25722)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "12397382;16303569;22673903;22935229;23077250;24497506;25133704;2559760;26485043;26636939;28012039;28202723;28428547;30389410;9613589", "class_list": "", "function": "Intramolecular distances computed from the LRET signals define a geometrical map of Nav1.4 with the bound toxins, and reveal voltage-dependent structural changes related to channel gating, [RefSeq, PubMed]; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient., [UniProtKB, UniProtKB]; Pore-forming subunit of Nav1.4, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:16303569, PubMed:2559760, PubMed:28012039). Highly expressed in skeletal muscles, Nav1.4 generates the action potential crucial for muscle contraction (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; Role of Asparagines in Coupling the Pore and Votage-Sensor Domain in Voltage-Gated Sodium Channels, [RefSeq, PubMed]; Role of a conserved neighbouring tryptophan residue at position 736 (W736) of Na(V)1.4 in the pore formation was examined. W736 contributes to the formation of the pore, close to the mouth of the channel, but is not part of the selectivity filter., [RefSeq, PubMed]; The role of the intracellular IFM motif of rNav1.4 (skeletal muscle isoform of the rat Na(+) channel) on the alpha-beta1 functional interaction, [RefSeq, PubMed]; The study constructs a homology model for the pore domain of the NaV1.4 channel and uses the functional data for the binding of micro-conotoxin GIIIA to NaV1.4 to validate the model. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 11, "predicted_n_glycosites": 9, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "O70611", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005248 voltage-gated sodium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0001518 voltage-gated sodium channel complex", "go_biological_process": "GO:0019228 neuronal action potential;GO:0019233 sensory perception of pain;GO:0086010 membrane depolarization during action potential;GO:0006812 monoatomic cation transport;GO:0006813 potassium ion transport", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P15390-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49803-1", "uniprot_id": [ { "id": "RGS7_RAT", "url": "https://www.uniprot.org/uniprot/P49803", "type": "external" } ], "mass": 55691.0, "length": 477, "protein_name": "Regulator of G protein signaling 7", "gene_name": "Rgs7", "organism": "Rat", "refseq_name": "regulator of G-protein signaling 7", "refseq_ac": [ { "id": "NP_062216", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062216", "type": "external" } ], "gene_names_uniprotkb": "Rgs7", "gene_names_refseq": "Rgs7", "protein_names_uniprotkb": "Regulator of G protein signaling 7; RGS7", "protein_names_refseq": "regulator of G-protein signaling 7", "tax_id": 10116, "disease": "non-syndromic X-linked intellectual disability (Disease Ontology:DOID:0050776); non-syndromic X-linked intellectual disability 63 (Disease Ontology:DOID:0112050); prostate cancer (Disease Ontology:DOID:10283); lung cancer (Disease Ontology:DOID:1324); Sjogren-Larsson syndrome (Disease Ontology:DOID:14501); depressive disorder (Disease Ontology:DOID:1596); breast cancer (Disease Ontology:DOID:1612); asthma (Disease Ontology:DOID:2841)", "pathway": " (rno:54296); (R-RNO-418594); (R-RNO-6814122)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10092682;22673903;8548815;9315921", "class_list": "", "function": "GTPase activator component of the RGS7-GNB5 complex that regulates G protein-coupled receptor signaling cascades. The RGS7-GNB5 complex acts as an inhibitor signal transduction by promoting the GTPase activity of G protein alpha subunits, such as GNAO1, thereby driving them into their inactive GDP-bound form. May play a role in synaptic vesicle exocytosis (By similarity). Glycine-dependent regulation of the RGS7-GNB5 complex by GPR158 affects mood and cognition via its ability to regulate neuronal excitability in L2/L3 pyramidal neurons of the prefrontal cortex (By similarity). Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling (PubMed:10092682)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9R0R0", "ec_number_list": [], "go_molecular_function": "GO:0031681 G-protein beta-subunit binding;GO:0005096 GTPase activator activity;GO:0001965 G-protein alpha-subunit binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0051286 cell tip;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005737 cytoplasm", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0035556 intracellular signal transduction;GO:0043547 positive regulation of GTPase activity;GO:0045471 response to ethanol;GO:0001975 response to amphetamine", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P49803-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A540-1", "uniprot_id": [ { "id": "AUGN_RAT", "url": "https://www.uniprot.org/uniprot/D4A540", "type": "external" } ], "mass": 16949.0, "length": 148, "protein_name": "Augurin", "gene_name": "Ecrg4", "organism": "Rat", "refseq_name": "augurin precursor", "refseq_ac": [ { "id": "NP_001257980", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257980", "type": "external" } ], "gene_names_uniprotkb": "Ecrg4", "gene_names_refseq": "Ecrg4; RGD1305645", "protein_names_uniprotkb": "Augurin; Esophageal cancer-related gene 4 protein homolog", "protein_names_refseq": "augurin precursor; augurin; esophageal cancer related gene 4 protein; esophageal cancer-related gene 4 protein homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:363225)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "20404145;21349154;21935431;23626679;26150152;26479776", "class_list": "", "function": "Augurin would play a constitutive inhibitory function in normal CNS while down regulation of Ecrg4 gene expression in injury, like in cancer, dysinhibits proliferation., [RefSeq, PubMed]; Ecrg4 plays a role in coordinating the inflammatory and proliferative response to infection of mucosal epithelium suggesting a possible mechanism for its putative anti-tumor activity. Publication Status: Online-Only, [RefSeq, PubMed]; Probable hormone that may attenuate cell proliferation and induce senescence of oligodendrocyte and neural precursor cells in the central nervous system (PubMed:20404145, PubMed:21349154). ECRG4-induced senescence is characterized by G1 arrest, RB1 dephosphorylation and accelerated CCND1 and CCND3 proteasomal degradation (PubMed:20404145)., [UniProtKB, PubMed, PubMed]; Ur identification of ECRG4 in many structures suggests the involvement of ECRG4 in the tumorigenesis of other organs Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005184 neuropeptide hormone activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0016324 apical plasma membrane;GO:0031045 dense core granule;GO:0005576 extracellular region", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0042127 regulation of cell population proliferation;GO:0007417 central nervous system development;GO:0031145 anaphase-promoting complex-dependent catabolic process;GO:0051461 positive regulation of corticotropin secretion", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "D4A540-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47709-1", "uniprot_id": [ { "id": "RP3A_RAT", "url": "https://www.uniprot.org/uniprot/P47709", "type": "external" } ], "mass": 75832.0, "length": 684, "protein_name": "Rabphilin-3A", "gene_name": "Rph3a", "organism": "Rat", "refseq_name": "rabphilin-3A isoform 1", "refseq_ac": [ { "id": "NP_598202", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598202", "type": "external" } ], "gene_names_uniprotkb": "Rph3a", "gene_names_refseq": "Rph3a", "protein_names_uniprotkb": "Rabphilin-3A; Exophilin-1", "protein_names_refseq": "exophilin-1; rabphilin 3A homolog; rabphilin-3A isoform 1", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515)", "pathway": " (rno:171039)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10025402;10559882;16203731;17166855;18683930;22673903;24302762;26679993;28634303;28823933;29367474;35626653;36173100;7946335;8060298;8617225", "class_list": "", "function": "Findings indicate that Rph3A activity is linked to the aberrant synaptic localization of GluN2A-expressing NMDARs characterizing levodopa-induced dyskinesias; suggest that Rph3A/GluN2A complex could represent an innovative therapeutic target for those pathological conditions where NMDAR composition is significantly altered., [RefSeq, PubMed]; Plays an essential role in docking and fusion steps of regulated exocytosis (PubMed:16203731, PubMed:8617225). At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP-dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release (PubMed:8617225). In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability (PubMed:26679993). Also plays a role in the exocytosis of arginine vasopressin hormone (PubMed:29367474)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Plays an essential role in docking and fusion steps of regulated exocytosis. At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP-dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release. In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability. Also plays a role in the exocytosis of arginine vasopressin hormone., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Rabphilin 3A binds the N-peptide of SNAP-25 to promote SNARE complex assembly in exocytosis. Publication Status: Online-Only, [RefSeq, PubMed]; Rabphilin-3A Drives Structural Modifications of Dendritic Spines Induced by Long-Term Potentiation. Publication Status: Online-Only, [RefSeq, PubMed]; Rph3A interacts with GluN2A and PSD-95 forming a complex that regulates NMDARs stabilization at postsynaptic membranes. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042301 phosphate ion binding;GO:0070679 inositol 1,4,5 trisphosphate binding;GO:0005543 phospholipid binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0098850 extrinsic component of synaptic vesicle membrane;GO:0030141 secretory granule;GO:0031594 neuromuscular junction;GO:0043197 dendritic spine;GO:0045202 synapse", "go_biological_process": "GO:0006886 intracellular protein transport;GO:2000310 regulation of NMDA receptor activity;GO:0097061 dendritic spine organization;GO:0045956 positive regulation of calcium ion-dependent exocytosis;GO:0061669 spontaneous neurotransmitter secretion", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P47709-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63155-1", "uniprot_id": [ { "id": "DCC_RAT", "url": "https://www.uniprot.org/uniprot/Q63155", "type": "external" } ], "mass": 157941.0, "length": 1445, "protein_name": "Netrin receptor DCC", "gene_name": "Dcc", "organism": "Rat", "refseq_name": "netrin receptor DCC precursor", "refseq_ac": [ { "id": "NP_036973", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036973", "type": "external" } ], "gene_names_uniprotkb": "Dcc", "gene_names_refseq": "Dcc", "protein_names_uniprotkb": "Netrin receptor DCC; Tumor suppressor protein DCC", "protein_names_refseq": "colorectal tumor suppressor; deleted in colorectal carcinoma; netrin receptor DCC precursor; netrin receptor DCC; putative colorectal tumor suppressor; tumor suppressor protein DCC", "tax_id": 10116, "disease": "mirror movements 1 (Disease Ontology:DOID:0070636); depressive disorder (Disease Ontology:DOID:1596); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:25311); (R-RNO-373752); (R-RNO-418885); (R-RNO-418889)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "10399920;21070949;23230270;23291093;24090084;30626732;33771901;8861902", "class_list": "", "function": "DCC activation of Src is required for NMDAR-dependent long-term potentiation and certain forms of learning and memory., [RefSeq, PubMed]; FEZ1 Forms Complexes with CRMP1 and DCC to Regulate Axon and Dendrite Development. Publication Status: Online-Only, [RefSeq, PubMed]; MiRs let-7 and miR-9 are involved in regulating neuron pathfinding and extend our understanding of the regulatory pathways active during peripheral nerve regeneration Erratum:[J Biol Chem. 2019 Apr 26;294(17):6695. doi: 10.1074/jbc.AAC119.008724. PMID: 31028164], [RefSeq, PubMed]; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Trio(Y2622) phosphorylation is essential for the regulation of the DCC/Trio signaling complex in cortical neurons during netrin-1-mediated axon outgrowth., [RefSeq, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 4, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0042802 identical protein binding;GO:0005042 netrin receptor activity", "go_cellular_component": "GO:0032584 growth cone membrane;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030424 axon;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0010976 positive regulation of neuron projection development;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0001764 neuron migration;GO:0001975 response to amphetamine;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q63155-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.1000000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q793F9-1", "uniprot_id": [ { "id": "VPS4A_RAT", "url": "https://www.uniprot.org/uniprot/Q793F9", "type": "external" } ], "mass": 48907.0, "length": 437, "protein_name": "Vacuolar protein sorting-associated protein 4A", "gene_name": "Vps4a", "organism": "Rat", "refseq_name": "vacuolar protein sorting-associated protein 4A", "refseq_ac": [ { "id": "NP_663711", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663711", "type": "external" } ], "gene_names_uniprotkb": "Vps4a; vps4-A", "gene_names_refseq": "Vps4a", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 4A; 3.6.4.6", "protein_names_refseq": "vacuolar protein sorting 4a; vacuolar protein sorting protein 4a; vacuolar protein sorting-associated protein 4A", "tax_id": 10116, "disease": "attention deficit hyperactivity disorder (Disease Ontology:DOID:1094)", "pathway": " (rno:246772); (R-RNO-917729); (R-RNO-9668328)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "22673903;28064406", "class_list": "", "function": "Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. It is required for proper accomplishment of various processes including the regulation of endosome size, primary cilium organization, mitotic spindle organization and chromosome segregation, and nuclear envelope sealing and spindle disassembly during anaphase (By similarity). In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. Involved in cytokinesis: retained at the midbody by ZFYVE19/ANCHR and CHMP4C until abscission checkpoint signaling is terminated at late cytokinesis. It is then released following dephosphorylation of CHMP4C, leading to abscission. VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). Critical for normal erythroblast cytokinesis and correct erythropoiesis (By similarity)., [UniProtKB, UniProtKB]; Vps4A was involved in promoting neuronal apoptosis via inhibiting Akt phosphorylation after intracerebral hemorrhage, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.1", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0044877 protein-containing complex binding;GO:0031267 small GTPase binding;GO:0140545 ATP-dependent protein disaggregase activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome", "go_biological_process": "GO:0036258 multivesicular body assembly;GO:0039702 viral budding via host ESCRT complex;GO:0061738 late endosomal microautophagy;GO:1903774 positive regulation of viral budding via host ESCRT complex;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q793F9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10719-1", "uniprot_id": [ { "id": "ATPB_RAT", "url": "https://www.uniprot.org/uniprot/P10719", "type": "external" } ], "mass": 56354.0, "length": 529, "protein_name": "ATP synthase F(1) complex catalytic subunit beta, mitochondrial", "gene_name": "Atp5f1b", "organism": "Rat", "refseq_name": "ATP synthase F(1) complex catalytic subunit beta, mitochondrial precursor", "refseq_ac": [ { "id": "NP_599191", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599191", "type": "external" } ], "gene_names_uniprotkb": "Atp5f1b; Atp5b", "gene_names_refseq": "Atp5b; Atp5f1b", "protein_names_uniprotkb": "ATP synthase F(1) complex catalytic subunit beta, mitochondrial; 7.1.2.2; ATP synthase F1 subunit beta", "protein_names_refseq": "ATP synthase F(1) complex catalytic subunit beta, mitochondrial precursor; ATP synthase F(1) complex catalytic subunit beta, mitochondrial; ATP synthase subunit beta, mitochondrial; ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit; ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide; mitochondrial ATP synthase beta subunit", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); polycystic ovary syndrome (Disease Ontology:DOID:11612); transient cerebral ischemia (Disease Ontology:DOID:224); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:171374); (R-RNO-1268020); (R-RNO-163210); (R-RNO-8949613); (R-RNO-9837999)", "pathway_count": 5, "publication_count": 19, "publication_id_list": "14673794;17575325;18047804;18683930;21926988;21933451;22673903;24098488;2522775;2531579;26446791;27213235;2894849;2907347;30552345;34502162;38843836;8764999;9736690", "class_list": "", "function": "Catalytic subunit beta, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. With the subunit alpha (ATP5F1A), forms the catalytic core in the F(1) domain., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; Catalytic subunit beta, of the soluble F(1) head domain within the mitochondrial ATP synthase complex (F(1)F(0) ATP synthase or complex V) that produces ATP from ADP and phosphate inorganique in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (PubMed:2531579). With the non-catalytic subunit alpha (ATP5F1A), forms the catalytic core in the F(1) domain. ATP synthase complex consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)., [UniProtKB, UniProtKB, PubMed]; Here, the authors show that the beta-chain of ATP synthase is a cell surface receptor for salusin-beta Publication Status: Online-Only, [RefSeq, PubMed]; Produces ATP from ADP in the presence of a proton gradient across the membrane., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 13, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 13, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 13, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "Q499W0", "ec_number_list": [ { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "2.1.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.3.3", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "2.5.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.39", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "1.1.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.41", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0043531 ADP binding;GO:0005509 calcium ion binding;GO:0043532 angiostatin binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:1904643 response to curcumin;GO:0001525 angiogenesis;GO:0001889 liver development;GO:0006629 lipid metabolic process;GO:0006754 ATP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "P10719-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29101-1", "uniprot_id": [ { "id": "SYT2_RAT", "url": "https://www.uniprot.org/uniprot/P29101", "type": "external" } ], "mass": 47210.0, "length": 422, "protein_name": "Synaptotagmin-2", "gene_name": "Syt2", "organism": "Rat", "refseq_name": "synaptotagmin-2", "refseq_ac": [ { "id": "NP_036797", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036797", "type": "external" } ], "gene_names_uniprotkb": "Syt2", "gene_names_refseq": "RATSYNII; SYNII; Syt2", "protein_names_uniprotkb": "Synaptotagmin-2; Synaptotagmin II; SytII", "protein_names_refseq": "synaptotagmin II; synaptotagmin-2; sytII", "tax_id": 10116, "disease": "congenital myasthenic syndrome 7 (Disease Ontology:DOID:0110659); vitiligo (Disease Ontology:DOID:12306); glaucoma (Disease Ontology:DOID:1686); congenital myasthenic syndrome (Disease Ontology:DOID:3635); neuromuscular junction disease (Disease Ontology:DOID:439)", "pathway": " (rno:24805); (R-RNO-8856825); (R-RNO-8856828)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "11823420;15123599;15350218;17167421;1856191;22673903;23932591;31431523;9867811", "class_list": "", "function": "(Microbial infection) Receptor for C.botulinum neurotoxin type B (BoNT/B, botB); unlike the case with BoNT/B interaction is not improved in the presence of gangliosides (PubMed:17167421). The toxin binds to the vesicular domain of Syt2 (residues 1-61) (PubMed:15123599)., [UniProtKB, PubMed]; (Microbial infection) Receptor for C.botulinum neurotoxin type G (BoNT/G, botG); unlike the case with BoNT/B interaction is not improved in the presence of gangliosides (PubMed:15123599). The toxin binds to the vesicular domain of Syt2 (residues 1-61) (PubMed:15123599)., [UniProtKB, PubMed]; A point mutation on synaptotagmin, located outside of the BoNT/B-binding segment, inhibited GT1b binding and blocked GT1b-induced potentiation of BoNT/B binding to synaptotagmin-expressing cells., [RefSeq, PubMed]; Crystal structure of the rat Syt2 protein botulinum neurotoxin DC complex., [RefSeq, PubMed]; Exhibits calcium-dependent phospholipid and inositol polyphosphate binding properties. May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. Plays a role in dendrite formation by melanocytes., [UniProtKB, UniProtKB, UniProtKB]; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 11, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding;GO:0005509 calcium ion binding;GO:0019905 syntaxin binding;GO:0005544 calcium-dependent phospholipid binding;GO:0000149 SNARE binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0031594 neuromuscular junction;GO:0043195 terminal bouton;GO:0030672 synaptic vesicle membrane", "go_biological_process": "GO:1903861 positive regulation of dendrite extension;GO:0030154 cell differentiation;GO:0016192 vesicle-mediated transport;GO:0017158 regulation of calcium ion-dependent exocytosis;GO:0016079 synaptic vesicle exocytosis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P29101-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4FZU9-1", "uniprot_id": [ { "id": "S52A3_RAT", "url": "https://www.uniprot.org/uniprot/Q4FZU9", "type": "external" } ], "mass": 50130.0, "length": 463, "protein_name": "Solute carrier family 52, riboflavin transporter, member 3", "gene_name": "Slc52a3", "organism": "Rat", "refseq_name": "solute carrier family 52, riboflavin transporter, member 3", "refseq_ac": [ { "id": "NP_001032275", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032275", "type": "external" } ], "gene_names_uniprotkb": "Slc52a3; Rft2", "gene_names_refseq": "RGD1304644; Rft2; Slc52a3; rRFT2", "protein_names_uniprotkb": "Solute carrier family 52, riboflavin transporter, member 3; Riboflavin transporter 2; rRFT2", "protein_names_refseq": "riboflavin transporter 2; solute carrier family 52, riboflavin transporter, member 3", "tax_id": 10116, "disease": "Brown-Vialetto-Van Laere syndrome (Disease Ontology:DOID:0050694); Fazio-Londe disease (Disease Ontology:DOID:0080632); Brown-Vialetto-Van Laere syndrome 1 (Disease Ontology:DOID:0080785)", "pathway": " (rno:311536); (R-RNO-196843)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "19122205;20724488;22673903;23413253;27964953", "class_list": "", "function": "Intestinal riboflavin uptake process undergoes differentiation-dependent upregulation and suggest that this is mediated (at least in part) via transcriptional mechanisms of Rft1 and Rft2., [RefSeq, PubMed]; Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; RFT2 may play a role in the intestinal absorption of riboflavin., [RefSeq, PubMed]; Results indicate that riboflavin transporter 2(RFT2) is a transporter involved in the epithelial uptake of riboflavin in the small intestine for its nutritional utilization, [RefSeq, PubMed]; The function and inhibition profile suggested the involvement of Slc52a3 in riboflavin transport at the inner BRB, and this is supported by expression and knockdown analysis of rRFVT2 (Slc52a2) and rRFVT3 (Slc52a3) in TR-iBRB2 cells., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0032217 riboflavin transmembrane transporter activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0034605 cellular response to heat;GO:0007605 sensory perception of sound;GO:0032218 riboflavin transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q4FZU9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88764-1", "uniprot_id": [ { "id": "DAPK3_RAT", "url": "https://www.uniprot.org/uniprot/O88764", "type": "external" } ], "mass": 51450.0, "length": 448, "protein_name": "Death-associated protein kinase 3", "gene_name": "Dapk3", "organism": "Rat", "refseq_name": "death-associated protein kinase 3", "refseq_ac": [ { "id": "NP_071991", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071991", "type": "external" } ], "gene_names_uniprotkb": "Dapk3; Zipk", "gene_names_refseq": "Dapk3; Dapkl", "protein_names_uniprotkb": "Death-associated protein kinase 3; 2.7.11.1; DAP kinase 3; DAP-like kinase; Dlk; MYPT1 kinase; ZIP-kinase", "protein_names_refseq": "DAP kinase 3; DAP-like kinase; Death-associated like kinase; MYPT1 kinase; ZIP-kinase; death-associated protein kinase 3; dlk", "tax_id": 10116, "disease": "", "pathway": " (rno:64391)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10580117;10602474;10602480;11384979;11884640;12560483;14582533;15096528;17953487;18084323;18505470;20854903;26111663;29393594;30851272;37084168;9840928", "class_list": "", "function": "DAPK3 modulated VSMC calcification through AMPK-mediated ERS signaling, [RefSeq, PubMed]; Death-associated protein kinase 3 regulates the myogenic reactivity of cerebral arteries., [RefSeq, PubMed]; Estrogen promotes ethanol-evoked myocardial oxidative stress and left ventricular dysfunction via DAPK3/Akt/ERK activation in male rats., [RefSeq, PubMed]; Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation and actin cytoskeleton reorganization. Regulates both type I (caspase-dependent) apoptotic and type II (caspase-independent) autophagic cell deaths signal, depending on the cellular setting. Involved in formation of promyelocytic leukemia protein nuclear body (PML-NB). Involved in apoptosis involving PAWR which mediates cytoplasmic relocation; in vitro phosphorylates PAWR. Regulates myosin phosphorylation in both smooth muscle and non-muscle cells. In smooth muscle, regulates myosin either directly by phosphorylating MYL12B and MYL9 or through inhibition of smooth muscle myosin phosphatase (SMPP1M) via phosphorylation of PPP1R12A; the inhibition of SMPP1M functions to enhance muscle responsiveness to Ca(2+) and promote a contractile state. Phosphorylates MYL12B in non-muscle cells leading to reorganization of actin cytoskeleton such as in regulation of cell polarity and cell migration. Positively regulates canonical Wnt/beta-catenin signaling through interaction with NLK and TCF7L2; disrupts the NLK-TCF7L2 complex thereby influencing the phosphorylation of TCF7L2 by NLK. Phosphorylates RPL13A on 'Ser-77' upon interferon-gamma activation which is causing RPL13A release from the ribosome, RPL13A association with the GAIT complex and its subsequent involvement in transcript-selective translation inhibition (By similarity). Phosphorylates STAT3 and enhances its transcriptional activity (By similarity). Enhances transcription from AR-responsive promoters in a hormone- and kinase-dependent manner. Phosphorylates histone H3 on 'Thr-11' at centromeres during mitosis., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005819 spindle;GO:0005829 cytosol", "go_biological_process": "GO:0051893 regulation of focal adhesion assembly;GO:0006351 DNA-templated transcription;GO:0006468 protein phosphorylation;GO:0030335 positive regulation of cell migration;GO:0032956 regulation of actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "O88764-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88828-1", "uniprot_id": [ { "id": "RPAB2_RAT", "url": "https://www.uniprot.org/uniprot/O88828", "type": "external" } ], "mass": 14464.0, "length": 127, "protein_name": "DNA-directed RNA polymerases I, II, and III subunit RPABC2", "gene_name": "Polr2f", "organism": "Rat", "refseq_name": "DNA-directed RNA polymerases I, II, and III subunit RPABC2", "refseq_ac": [ { "id": "NP_112625", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112625", "type": "external" } ], "gene_names_uniprotkb": "Polr2f", "gene_names_refseq": "Polr2f", "protein_names_uniprotkb": "DNA-directed RNA polymerases I, II, and III subunit RPABC2; DNA-directed RNA polymerase II subunit F; RNA polymerases I, II, and III subunit ABC2; RPB6 homolog", "protein_names_refseq": "DNA-directed RNA polymerase II subunit F; DNA-directed RNA polymerases I, II, and III subunit RPABC2; RNA polymerases I, II, and III subunit ABC2; RPB6 homolog; polymerase (RNA) II (DNA directed) polypeptide F; polymerase (RNA) II subunit F", "tax_id": 10116, "disease": "", "pathway": " (rno:83503); (R-RNO-112382); (R-RNO-113418); (R-RNO-5250924); (R-RNO-5578749); (R-RNO-674695); (R-RNO-6781823); (R-RNO-6782135); (R-RNO-6782210); (R-RNO-6796648); (R-RNO-6803529); (R-RNO-6807505); (R-RNO-72086); (R-RNO-72163); (R-RNO-72165); (R-RNO-72203); (R-RNO-73762); (R-RNO-73772); (R-RNO-73776); (R-RNO-73779); (R-RNO-73863); (R-RNO-75953); (R-RNO-75955); (R-RNO-76042); (R-RNO-76061); (R-RNO-76066); (R-RNO-76071); (R-RNO-77075); (R-RNO-9018519); (R-RNO-9770562)", "pathway_count": 30, "publication_count": 2, "publication_id_list": "10393248;22673903", "class_list": "", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II, and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2F/RPABC2 is part of the clamp element and together with parts of POLR2A/RPB1 and POLR2B/RPB2 forms a pocket to which the POLR2D/RPB4-POLR2G/RPB7 subcomplex binds., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0001650 fibrillar center;GO:0005665 RNA polymerase II, core complex;GO:0005736 RNA polymerase I complex", "go_biological_process": "GO:0006360 transcription by RNA polymerase I;GO:0042797 tRNA transcription by RNA polymerase III;GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006368 transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O88828-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04256-1", "uniprot_id": [ { "id": "ROA1_RAT", "url": "https://www.uniprot.org/uniprot/P04256", "type": "external" } ], "mass": 34212.0, "length": 320, "protein_name": "Heterogeneous nuclear ribonucleoprotein A1", "gene_name": "Hnrnpa1", "organism": "Rat", "refseq_name": "heterogeneous nuclear ribonucleoprotein A1 isoform 2", "refseq_ac": [ { "id": "NP_058944", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058944", "type": "external" } ], "gene_names_uniprotkb": "Hnrnpa1; Hnrpa1", "gene_names_refseq": "Hnrnpa1; Hnrpa1; hnRNP A1", "protein_names_uniprotkb": "Heterogeneous nuclear ribonucleoprotein A1; HDP; Helix-destabilizing protein; Single-strand RNA-binding protein; hnRNP A1; hnRNP core protein A1", "protein_names_refseq": "HDP; helix-destabilizing protein; heterogeneous nuclear ribonucleoprotein A1 isoform 2; hnRNP core protein A1; single-strand RNA-binding protein", "tax_id": 10116, "disease": "inclusion body myopathy with Paget disease of bone and frontotemporal dementia (Disease Ontology:DOID:0050881); amyotrophic lateral sclerosis type 20 (Disease Ontology:DOID:0060211); distal myopathy 3 (Disease Ontology:DOID:0111189); inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 3 (Disease Ontology:DOID:0111386); Alzheimer's disease (Disease Ontology:DOID:10652); neurodegenerative disease (Disease Ontology:DOID:1289); HTLV-1-associated myelopathy/tropical spastic paraparesis (Disease Ontology:DOID:321); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:29578); (R-RNO-6803529); (R-RNO-72163); (R-RNO-72203); (R-RNO-9770562)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "18683930;24098712;2447078;3005291;34502162;38003404;38843836", "class_list": "", "function": "Increase in hnRNPA1 Expression Suffices to Kill Motor Neurons in Transgenic Rats. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection. Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform. Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1. May bind to specific miRNA hairpins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0036002 pre-mRNA binding;GO:1990825 sequence-specific mRNA binding;GO:0098505 G-rich strand telomeric DNA binding;GO:0061752 telomeric repeat-containing RNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0045202 synapse;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0030324 lung development;GO:0051170 import into nucleus;GO:0008584 male gonad development;GO:0032211 negative regulation of telomere maintenance via telomerase", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P04256-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11507-1", "uniprot_id": [ { "id": "AT2A2_RAT", "url": "https://www.uniprot.org/uniprot/P11507", "type": "external" } ], "mass": 114768.0, "length": 1043, "protein_name": "Sarcoplasmic/endoplasmic reticulum calcium ATPase 2", "gene_name": "Atp2a2", "organism": "Rat", "refseq_name": "sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform a", "refseq_ac": [ { "id": "NP_001103609", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103609", "type": "external" } ], "gene_names_uniprotkb": "Atp2a2", "gene_names_refseq": "Atp2a2; Serca2; SercaII", "protein_names_uniprotkb": "Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; 7.2.2.10; Calcium pump 2; Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform; Endoplasmic reticulum class 1/2 Ca(2+) ATPase; SERCA2; SR Ca(2+)-ATPase 2", "protein_names_refseq": "ATPase, Ca++ transporting, cardiac muscle, slow twitch 2; ATPase, Ca++ transporting, slow twitch 2; SR Ca(2+)-ATPase 2; calcium pump 2; endoplasmic reticulum class 1/2 Ca(2+) ATPase; sarco(endo)plasmic reticulum Ca(2+)-dependent ATPase 2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform a; sarcoplasmic/endoplasmic reticulum calcium ATPase 2", "tax_id": 10116, "disease": "acrokeratosis verruciformis (Disease Ontology:DOID:0050606); Brody myopathy (Disease Ontology:DOID:0050692); essential hypertension (Disease Ontology:DOID:10825); heart disease (Disease Ontology:DOID:114); abdominal obesity-metabolic syndrome 1 (Disease Ontology:DOID:14221); hypothyroidism (Disease Ontology:DOID:1459); keratosis follicularis (Disease Ontology:DOID:2734); euthyroid sick syndrome (Disease Ontology:DOID:2856); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:29693); (R-RNO-418359); (R-RNO-5578775); (R-RNO-936837)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "10359649;16399855;18683930;22673903;23132757;2542094;2844797;33130073;33689540;34502162;35331264;35988281;37897375;38843836", "class_list": "", "function": "Catalyzes the hydrolysis of ATP coupled with the transport of calcium., [UniProtKB, UniProtKB]; Effects of MiR-214-3p Regulation of SERCA2a Expression on Contractility of Cardiomyocytes in Heart Failure Model. Publication Status: Online-Only, [RefSeq, PubMed]; Estrogen inhibits endoplasmic reticulum stress and ameliorates myocardial ischemia/reperfusion injury in rats by upregulating SERCA2a. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca(2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca(2+) signaling cascades that promote osteoclast differentiation and activation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Oxidative stress in early metabolic syndrome impairs cardiac RyR2 and SERCA2a activity and modifies the interplay of these proteins during Ca[2+] waves., [RefSeq, PubMed]; Relative role of T-tubules disruption and decreased SERCA2 on contractile dynamics of isolated rat ventricular myocytes., [RefSeq, PubMed]; Remote ischemic postconditioning alleviates cerebral ischemic injury through SERCA2/endoplasmic reticulum stress-mediated apoptosis., [RefSeq, PubMed]; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation. Also modulates ER contacts with lipid droplets, mitochondria and endosomes (By similarity). In coordination with FLVCR2 mediates heme-stimulated switching from mitochondrial ATP synthesis to thermogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P11508", "ec_number_list": [ { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "7.2.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.10", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0005246 calcium channel regulator activity;GO:0016887 ATP hydrolysis activity;GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0031234 extrinsic component of cytoplasmic side of plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0032496 response to lipopolysaccharide;GO:0006816 calcium ion transport;GO:0006874 intracellular calcium ion homeostasis;GO:0034605 cellular response to heat", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P11507-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P25977-1", "uniprot_id": [ { "id": "UBF1_RAT", "url": "https://www.uniprot.org/uniprot/P25977", "type": "external" } ], "mass": 89437.0, "length": 764, "protein_name": "Nucleolar transcription factor 1", "gene_name": "Ubtf", "organism": "Rat", "refseq_name": "nucleolar transcription factor 1 isoform 1", "refseq_ac": [ { "id": "NP_001099193", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099193", "type": "external" } ], "gene_names_uniprotkb": "Ubtf; Tcfubf; Ubf-1", "gene_names_refseq": "Tcfubf; Ubtf", "protein_names_uniprotkb": "Nucleolar transcription factor 1; UBF-1; Upstream-binding factor 1", "protein_names_refseq": "UBF-1; nucleolar transcription factor 1 isoform 1; nucleolar transcription factor 1; transcription factor UBF; upstream binding transcription factor, RNA polymerase I; upstream-binding factor 1", "tax_id": 10116, "disease": "childhood-onset neurodegeneration with brain atrophy (Disease Ontology:DOID:0070474)", "pathway": " (rno:25574); (R-RNO-73728); (R-RNO-73762); (R-RNO-73772); (R-RNO-73863)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "10099786;11106745;20075868;2014238", "class_list": "", "function": "Competitive recruitment of CBP and Rb-HDAC regulates UBF acetylation and ribosomal transcription, [RefSeq, PubMed]; Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P25978", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0097110 scaffold protein binding;GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding;GO:0001165 RNA polymerase I cis-regulatory region sequence-specific DNA binding;GO:0001181 RNA polymerase I general transcription initiation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0001650 fibrillar center", "go_biological_process": "GO:0006360 transcription by RNA polymerase I;GO:1990830 cellular response to leukemia inhibitory factor;GO:0000183 rDNA heterochromatin formation;GO:0045943 positive regulation of transcription by RNA polymerase I;GO:0006362 transcription elongation by RNA polymerase I", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P25977-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33568-1", "uniprot_id": [ { "id": "RB_RAT", "url": "https://www.uniprot.org/uniprot/P33568", "type": "external" } ], "mass": 105025.0, "length": 920, "protein_name": "Retinoblastoma-associated protein", "gene_name": "Rb1", "organism": "Rat", "refseq_name": "retinoblastoma-associated protein", "refseq_ac": [ { "id": "NP_058741", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058741", "type": "external" } ], "gene_names_uniprotkb": "Rb1; Rb-1", "gene_names_refseq": "Rb1", "protein_names_uniprotkb": "Retinoblastoma-associated protein; Rb; pRb; pp105", "protein_names_refseq": "Retinoblastoma 1 (including osteosarcoma); pRb; pp105; retinoblastoma protein; retinoblastoma-associated protein", "tax_id": 10116, "disease": "small cell carcinoma (Disease Ontology:DOID:0050685); glioblastoma proneural subtype (Disease Ontology:DOID:0050804); ductal carcinoma in situ (Disease Ontology:DOID:0060074); prostate cancer (Disease Ontology:DOID:10283); intellectual disability (Disease Ontology:DOID:1059); urinary bladder cancer (Disease Ontology:DOID:11054); cancer (Disease Ontology:DOID:162); acute kidney failure (Disease Ontology:DOID:3021); glioblastoma (Disease Ontology:DOID:3068); oligodendroglioma (Disease Ontology:DOID:3181); embryonal carcinoma (Disease Ontology:DOID:3308); osteosarcoma (Disease Ontology:DOID:3347); seminoma (Disease Ontology:DOID:4440); renal cell carcinoma (Disease Ontology:DOID:4450); familial retinoblastoma (Disease Ontology:DOID:4648); hepatocellular carcinoma (Disease Ontology:DOID:684); retinoblastoma (Disease Ontology:DOID:768); in situ carcinoma (Disease Ontology:DOID:8719); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24708); (R-RNO-113501); (R-RNO-174178); (R-RNO-2299718); (R-RNO-2559584); (R-RNO-69200); (R-RNO-69202); (R-RNO-69231); (R-RNO-69656); (R-RNO-9841922)", "pathway_count": 10, "publication_count": 10, "publication_id_list": "10542199;10888886;10952156;19081374;22673903;27056896;29393594;7665085;8441612;9697699", "class_list": "", "function": "Identify Dyrk1a as a novel negative regulator of D-cyclin-mediated Rb1/E2f-signalling. As dysregulation of this pathway with impaired cardiomyocyte proliferation leads to cardiomyopathy., [RefSeq, PubMed]; Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle. The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes. Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription. Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase. RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter (PubMed:19081374). In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 20, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 20, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q63527", "ec_number_list": [], "go_molecular_function": "GO:0061676 importin-alpha family protein binding;GO:0060090 molecular adaptor activity;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005819 spindle;GO:0005667 transcription regulator complex", "go_biological_process": "GO:1903055 positive regulation of extracellular matrix organization;GO:1903944 negative regulation of hepatocyte apoptotic process;GO:0043353 enucleate erythrocyte differentiation;GO:0071459 protein localization to chromosome, centromeric region;GO:1904761 negative regulation of myofibroblast differentiation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P33568-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35739-1", "uniprot_id": [ { "id": "NTRK1_RAT", "url": "https://www.uniprot.org/uniprot/P35739", "type": "external" } ], "mass": 87868.0, "length": 799, "protein_name": "High affinity nerve growth factor receptor", "gene_name": "Ntrk1", "organism": "Rat", "refseq_name": "high affinity nerve growth factor receptor precursor", "refseq_ac": [ { "id": "NP_067600", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067600", "type": "external" } ], "gene_names_uniprotkb": "Ntrk1; Trka; Trk", "gene_names_refseq": "Ntrk1; Trk", "protein_names_uniprotkb": "High affinity nerve growth factor receptor; 2.7.10.1; Neurotrophic tyrosine kinase receptor type 1; Slow nerve growth factor receptor; Trk-A; p140-TrkA", "protein_names_refseq": "TrkA neurotrophin receptor; high affinity nerve growth factor receptor precursor; high affinity nerve growth factor receptor; neurotrophic tyrosine kinase, receptor, type 1; p140-TrkA; slow nerve growth factor receptor; trk-A; trkA proto-oncogene receptor; tropomyosin-related kinase A", "tax_id": 10116, "disease": "hereditary sensory and autonomic neuropathy (Disease Ontology:DOID:0050548); obstructive sleep apnea (Disease Ontology:DOID:0050848); colitis (Disease Ontology:DOID:0060180); congenital insensitivity to pain with anhidrosis (Disease Ontology:DOID:0070146); Parkinsonism (Disease Ontology:DOID:0080855); Hirschsprung's disease (Disease Ontology:DOID:10487); Alzheimer's disease (Disease Ontology:DOID:10652); pulmonary sarcoidosis (Disease Ontology:DOID:13406); glaucoma (Disease Ontology:DOID:1686); pancreatic cancer (Disease Ontology:DOID:1793); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); atopic dermatitis (Disease Ontology:DOID:3310); myofascial pain syndrome (Disease Ontology:DOID:431); rhinitis (Disease Ontology:DOID:4483); retinal detachment (Disease Ontology:DOID:5327); schizophrenia (Disease Ontology:DOID:5419); neuroblastoma (Disease Ontology:DOID:769); periodontitis (Disease Ontology:DOID:824); diabetic neuropathy (Disease Ontology:DOID:9743)", "pathway": " (rno:59109); (R-RNO-1257604); (R-RNO-170968); (R-RNO-170984); (R-RNO-177504); (R-RNO-187042); (R-RNO-198203)", "pathway_count": 7, "publication_count": 24, "publication_id_list": "10748052;11150334;11244088;12471037;1312719;15167895;15378608;16223723;16306406;17724123;17967490;1850821;18624909;20811452;26446845;31440771;33043964;33125501;34943971;36575400;38725127;8155326;8325889;9856458", "class_list": "", "function": "Comparison of tyrosine kinase domain properties for the neurotrophin receptors TrkA and TrkB., [RefSeq, PubMed]; EFA6A, an Exchange Factor for Arf6, Regulates NGF-Dependent TrkA Recycling From Early Endosomes and Neurite Outgrowth in PC12 Cells., [RefSeq, PubMed]; Increased hippocampal TrkA expression ameliorates cranial radiationinduced neurogenesis impairment and cognitive deficit via PI3K/AKT signaling., [RefSeq, PubMed]; Ntrk1 promotes mesangial cell proliferation and inflammation in rat glomerulonephritis model by activating the STAT3 and p38/ERK MAPK signaling pathways. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand (PubMed:1312719, PubMed:1850821, PubMed:31440771). Can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Small Endogenous Ligands Modulation of Nerve Growth Factor Bioactivity: A Structural Biology Overview. Review article Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 11, "predicted_n_glycosites": 11, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 20, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" } ], "go_molecular_function": "GO:0048406 nerve growth factor binding;GO:0043121 neurotrophin binding;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005769 early endosome;GO:0005886 plasma membrane", "go_biological_process": "GO:0046579 positive regulation of Ras protein signal transduction;GO:0021553 olfactory nerve development;GO:0060384 innervation;GO:0061368 behavioral response to formalin induced pain;GO:0042490 mechanoreceptor differentiation", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P35739-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41542-1", "uniprot_id": [ { "id": "USO1_RAT", "url": "https://www.uniprot.org/uniprot/P41542", "type": "external" } ], "mass": 107162.0, "length": 959, "protein_name": "General vesicular transport factor p115", "gene_name": "Uso1", "organism": "Rat", "refseq_name": "general vesicular transport factor p115", "refseq_ac": [ { "id": "NP_062252", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062252", "type": "external" } ], "gene_names_uniprotkb": "Uso1; Vdp", "gene_names_refseq": "TAP; Uso1; Vdp", "protein_names_uniprotkb": "General vesicular transport factor p115; Protein USO1 homolog; TAP; Transcytosis-associated protein; Vesicle-docking protein", "protein_names_refseq": "general vesicular transport factor p115; protein USO1 homolog; transcytosis-associated protein; vesicle docking protein, 115 kDa; vesicle-docking protein", "tax_id": 10116, "disease": "", "pathway": " (rno:56042); (R-RNO-204005); (R-RNO-6807878)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10679020;10744704;10769027;16641100;22673903;25406594;29393594;7831323;7831324;9150144;9753325", "class_list": "", "function": "General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane (PubMed:10679020, PubMed:7831323, PubMed:7831324). May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity (PubMed:10679020, PubMed:7831323, PubMed:7831324)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Monomeric SNAREs are a major binding site for p115 on COPII vesicles, and that p115 dissociates from its SNARE partners upon SNAREpin assembly., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:1900076 regulation of cellular response to insulin stimulus;GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0007264 small GTPase-mediated signal transduction;GO:0061025 membrane fusion", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P41542-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V7B5-1", "uniprot_id": [ { "id": "TEKL1_RAT", "url": "https://www.uniprot.org/uniprot/Q4V7B5", "type": "external" } ], "mass": 57466.0, "length": 500, "protein_name": "Tektin-like protein 1", "gene_name": "Tektl1", "organism": "Rat", "refseq_name": "tektin-like protein 1", "refseq_ac": [ { "id": "NP_001020945", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020945", "type": "external" } ], "gene_names_uniprotkb": "Tektl1; Ccdc105", "gene_names_refseq": "Ccdc105; Tektl1", "protein_names_uniprotkb": "Tektin-like protein 1; Coiled-coil domain-containing protein 105", "protein_names_refseq": "coiled-coil domain containing 105; coiled-coil domain-containing protein 105; tektin-like protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:500800)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in sperm flagellar axoneme, which is required for motile flagellum beating (By similarity). Forms an extensive interaction network cross-linking the lumen of axonemal doublet microtubules (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0036126 sperm flagellum;GO:0160112 axonemal B tubule inner sheath", "go_biological_process": "GO:0030317 flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4V7B5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q568Z0-1", "uniprot_id": [ { "id": "T11L2_RAT", "url": "https://www.uniprot.org/uniprot/Q568Z0", "type": "external" } ], "mass": 57980.0, "length": 517, "protein_name": "T-complex protein 11-like protein 2", "gene_name": "Tcp11l2", "organism": "Rat", "refseq_name": "T-complex protein 11-like protein 2", "refseq_ac": [ { "id": "NP_001017458", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017458", "type": "external" } ], "gene_names_uniprotkb": "Tcp11l2", "gene_names_refseq": "RGD1307494; Tcp11l2", "protein_names_uniprotkb": "T-complex protein 11-like protein 2", "protein_names_refseq": "T-complex protein 11-like protein 2; t-complex 11, testis-specific-like 2", "tax_id": 10116, "disease": "", "pathway": " (rno:314683)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Promotes the migration of muscle-derived satellite cells (MDSCs) during differentiation throught interaction with FMNL2 and therefore may participate in microfilament assembly., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0016607 nuclear speck", "go_biological_process": "GO:0007165 signal transduction;GO:0014812 muscle cell migration", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q568Z0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PQV5-1", "uniprot_id": [ { "id": "TPBG_RAT", "url": "https://www.uniprot.org/uniprot/Q5PQV5", "type": "external" } ], "mass": 46508.0, "length": 426, "protein_name": "Trophoblast glycoprotein", "gene_name": "Tpbg", "organism": "Rat", "refseq_name": "trophoblast glycoprotein precursor", "refseq_ac": [ { "id": "NP_001418560", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001418560", "type": "external" } ], "gene_names_uniprotkb": "Tpbg; 5t4", "gene_names_refseq": "5T4; Tpbg; WAIF1", "protein_names_uniprotkb": "Trophoblast glycoprotein; 5T4 oncofetal trophoblast glycoprotein; 5T4 oncotrophoblast glycoprotein; WAIF1; Wnt-activated inhibitory factor 1", "protein_names_refseq": "5T4 oncofetal trophoblast glycoprotein; 5T4 oncotrophoblast glycoprotein; trophoblast glycoprotein precursor; wnt-activated inhibitory factor 1", "tax_id": 10116, "disease": "", "pathway": " (rno:83684)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;24090084", "class_list": "", "function": "May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 188, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9QYD9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0043679 axon terminus", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0072659 protein localization to plasma membrane;GO:0090090 negative regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q5PQV5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64542-1", "uniprot_id": [ { "id": "AT2B4_RAT", "url": "https://www.uniprot.org/uniprot/Q64542", "type": "external" } ], "mass": 133094.0, "length": 1203, "protein_name": "Plasma membrane calcium-transporting ATPase 4", "gene_name": "Atp2b4", "organism": "Rat", "refseq_name": "plasma membrane calcium-transporting ATPase 4", "refseq_ac": [ { "id": "NP_001005871", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005871", "type": "external" } ], "gene_names_uniprotkb": "Atp2b4", "gene_names_refseq": "Atp2b4; PMCA4", "protein_names_uniprotkb": "Plasma membrane calcium-transporting ATPase 4; 7.2.2.10; PMCA4; Plasma membrane calcium ATPase isoform 4; Plasma membrane calcium pump isoform 4", "protein_names_refseq": "ATPase, Ca++ transporting, plasma membrane 4; plasma membrane Ca2+-ATPases 4; plasma membrane calcium ATPase; plasma membrane calcium pump; plasma membrane calcium-transporting ATPase 4", "tax_id": 10116, "disease": "Hailey-Hailey disease (Disease Ontology:DOID:0050429); pre-eclampsia (Disease Ontology:DOID:10591); gestational diabetes (Disease Ontology:DOID:11714); dystonia (Disease Ontology:DOID:543)", "pathway": " (rno:29600); (R-RNO-418359); (R-RNO-5578775); (R-RNO-936837)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "22673903;37882330;38843836;7702574;7945253;8428948", "class_list": "", "function": "Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell (By similarity). By regulating sperm cell calcium homeostasis, may play a role in sperm motility (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Mammalian cysteine-rich secretory proteins interact with plasma membrane Ca[2+] exporter PMCA4b., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q63127;Q63445;Q64543;Q64544;Q64545", "ec_number_list": [ { "id": "7.2.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" } ], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0003407 neural retina development;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:0010629 negative regulation of gene expression;GO:0006816 calcium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q64542-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q75Q39-1", "uniprot_id": [ { "id": "TOM70_RAT", "url": "https://www.uniprot.org/uniprot/Q75Q39", "type": "external" } ], "mass": 67445.0, "length": 610, "protein_name": "Mitochondrial import receptor subunit TOM70", "gene_name": "Tomm70", "organism": "Rat", "refseq_name": "mitochondrial import receptor subunit TOM70", "refseq_ac": [ { "id": "NP_997684", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997684", "type": "external" } ], "gene_names_uniprotkb": "Tomm70; Tomm70a", "gene_names_refseq": "TOM70; Tomm70a; Tomm70", "protein_names_uniprotkb": "Mitochondrial import receptor subunit TOM70; Mitochondrial precursor proteins import receptor; Translocase of outer membrane 70 kDa subunit; Translocase of outer mitochondrial membrane protein 70", "protein_names_refseq": "mitochondrial import receptor subunit TOM70; mitochondrial precursor proteins import receptor; translocase of outer membrane 70 kDa subunit; translocase of outer mitochondrial membrane protein 70", "tax_id": 10116, "disease": "hypothyroidism (Disease Ontology:DOID:1459); congestive heart failure (Disease Ontology:DOID:6000); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (rno:304017); (R-RNO-168928); (R-RNO-5205685); (R-RNO-5689880)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "11956321;16396499;19401463;22673903;27919679", "class_list": "", "function": "Acts as a receptor of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex). Recognizes and mediates the translocation of mitochondrial preproteins from the cytosol into the mitochondria in a chaperone dependent manner (PubMed:11956321, PubMed:19401463). Mediates TBK1 and IRF3 activation induced by MAVS in response to Sendai virus infection and promotes host antiviral responses during virus infection (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Adenosine-induced translocation of PKCepsilon to mitochondria is mediated by a caveolin-3-dependent mechanism and this process is age-related, possibly in part, through regulation of HSP90 and TOM70 expression, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0030943 mitochondrion targeting sequence binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development;GO:0097068 response to thyroxine;GO:0045039 protein insertion into mitochondrial inner membrane;GO:1903955 positive regulation of protein targeting to mitochondrion;GO:0006626 protein targeting to mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q75Q39-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CJB9-1", "uniprot_id": [ { "id": "BRE1B_RAT", "url": "https://www.uniprot.org/uniprot/Q8CJB9", "type": "external" } ], "mass": 113841.0, "length": 1002, "protein_name": "E3 ubiquitin-protein ligase BRE1B", "gene_name": "Rnf40", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase BRE1B", "refseq_ac": [ { "id": "NP_703201", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_703201", "type": "external" } ], "gene_names_uniprotkb": "Rnf40; Bre1b", "gene_names_refseq": "Rnf40", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase BRE1B; 2.3.2.27; BRE1-B; Protein staring; RING finger protein 40; RING-type E3 ubiquitin transferase BRE1B; Syntaxin-1-interacting RING finger protein", "protein_names_refseq": "BRE1-B; E3 ubiquitin-protein ligase BRE1B; RING-type E3 ubiquitin transferase BRE1B; protein staring; ring finger protein 40, E3 ubiquitin protein ligase; staring protein; syntaxin-1-interacting RING finger protein", "tax_id": 10116, "disease": "nephrogenic diabetes insipidus (Disease Ontology:DOID:12387); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (rno:266712); (R-RNO-8866654)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "12121982;22673903", "class_list": "", "function": "A novel E3 ubiquitin-protein ligase that targets syntaxin 1 for degradation, [RefSeq, PubMed]; Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0031625 ubiquitin protein ligase binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000151 ubiquitin ligase complex;GO:0032991 protein-containing complex;GO:0033503 HULC complex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0016567 protein ubiquitination;GO:0006325 chromatin organization;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8CJB9-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q925D4-1", "uniprot_id": [ { "id": "T176B_RAT", "url": "https://www.uniprot.org/uniprot/Q925D4", "type": "external" } ], "mass": 28485.0, "length": 263, "protein_name": "Transmembrane protein 176B", "gene_name": "Tmem176b", "organism": "Rat", "refseq_name": "transmembrane protein 176B", "refseq_ac": [ { "id": "NP_001257518", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257518", "type": "external" } ], "gene_names_uniprotkb": "Tmem176b; Lr8; Torid", "gene_names_refseq": "Lr8; Tmem176b; Torid", "protein_names_uniprotkb": "Transmembrane protein 176B; Protein LR8; Tolerance-related and induced transcript protein", "protein_names_refseq": "TORID; tolerance-related and induced transcript protein; transmembrane protein 176B", "tax_id": 10116, "disease": "", "pathway": " (rno:171411)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16095493;22673903", "class_list": "", "function": "Required for the development of cerebellar granule cells (By similarity). May play a role in the process of maturation of dendritic cells., [UniProtKB, PubMed]; TORID may be involved in the control of DC maturation and may, therefore, play a role in the induction or maintenance of allograft tolerance, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0031965 nuclear membrane", "go_biological_process": "GO:0030154 cell differentiation;GO:2001199 negative regulation of dendritic cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q925D4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ES53-1", "uniprot_id": [ { "id": "UFD1_RAT", "url": "https://www.uniprot.org/uniprot/Q9ES53", "type": "external" } ], "mass": 34485.0, "length": 307, "protein_name": "Ubiquitin recognition factor in ER-associated degradation protein 1", "gene_name": "Ufd1", "organism": "Rat", "refseq_name": "ubiquitin recognition factor in ER-associated degradation protein 1", "refseq_ac": [ { "id": "NP_445870", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445870", "type": "external" } ], "gene_names_uniprotkb": "Ufd1; Ufd1l", "gene_names_refseq": "Ufd1", "protein_names_uniprotkb": "Ubiquitin recognition factor in ER-associated degradation protein 1; UB fusion protein 1; Ubiquitin fusion degradation protein 1 homolog", "protein_names_refseq": "UB fusion protein 1; ubiquitin fusion degradation 1 like; ubiquitin fusion degradation protein 1 homolog; ubiquitin recognition factor in ER-associated degradation protein 1", "tax_id": 10116, "disease": "DiGeorge syndrome (Disease Ontology:DOID:11198); velocardiofacial syndrome (Disease Ontology:DOID:12583); neurodegenerative disease (Disease Ontology:DOID:1289); schizophrenia (Disease Ontology:DOID:5419); cleft palate (Disease Ontology:DOID:674)", "pathway": " (rno:84478); (R-RNO-110320); (R-RNO-5689880); (R-RNO-8951664); (R-RNO-9755511)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "10811609;22673903", "class_list": "", "function": "Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures (PubMed:10811609). Acts as a negative regulator of type I interferon production via the complex formed with VCP and NPLOC4, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0036435 K48-linked polyubiquitin modification-dependent protein binding;GO:0005102 signaling receptor binding;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0051117 ATPase binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0036501 UFD1-NPL4 complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0036503 ERAD pathway;GO:0071218 cellular response to misfolded protein;GO:0030970 retrograde protein transport, ER to cytosol", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9ES53-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZE9-1", "uniprot_id": [ { "id": "T150A_RAT", "url": "https://www.uniprot.org/uniprot/Q9QZE9", "type": "external" } ], "mass": 29050.0, "length": 271, "protein_name": "Transmembrane protein 150A", "gene_name": "Tmem150a", "organism": "Rat", "refseq_name": "transmembrane protein 150A precursor", "refseq_ac": [ { "id": "NP_620807", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620807", "type": "external" } ], "gene_names_uniprotkb": "Tmem150a; Tm6p1; Tmem150", "gene_names_refseq": "Tm6p1; Tmem150a; Tmem150", "protein_names_uniprotkb": "Transmembrane protein 150A; Fasting-inducible integral membrane protein TM6P1; Transmembrane protein 150", "protein_names_refseq": "fasting-inducible integral membrane protein TM6P1; fasting-inducible; membrane integrated protein containing 6 transmembrane domains; transmembrane protein 150A precursor; transmembrane protein 150", "tax_id": 10116, "disease": "", "pathway": " (rno:245966)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10858565", "class_list": "", "function": "Possible role in fasting-induced catabolism., [UniProtKB, PubMed]; Regulates localization of phosphatidylinositol 4-kinase (PI4K) to the plasma membrane, possibly by reducing the association of TTC7 (TTC7A or TTC7B) with the PI4K complex. Acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (By similarity). May also play a role in fasting-induced catabolism (PubMed:10858565)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0046854 phosphatidylinositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9QZE9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0T4-1", "uniprot_id": [ { "id": "CADH1_RAT", "url": "https://www.uniprot.org/uniprot/Q9R0T4", "type": "external" } ], "mass": 98715.0, "length": 886, "protein_name": "Cadherin-1", "gene_name": "Cdh1", "organism": "Rat", "refseq_name": "cadherin-1 precursor", "refseq_ac": [ { "id": "NP_112624", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112624", "type": "external" } ], "gene_names_uniprotkb": "Cdh1", "gene_names_refseq": "Cdh1", "protein_names_uniprotkb": "Cadherin-1; E-cadherin; Epithelial cadherin; Uvomorulin", "protein_names_refseq": "E-cadherin; cadherin-1 precursor; epithelial cadherin; uvomorulin", "tax_id": 10116, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); blepharocheilodontic syndrome 1 (Disease Ontology:DOID:0080345); hereditary diffuse gastric cancer (Disease Ontology:DOID:0080764); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); endometrial cancer (Disease Ontology:DOID:1380); breast cancer (Disease Ontology:DOID:1612); ovarian cancer (Disease Ontology:DOID:2394); asthma (Disease Ontology:DOID:2841); invasive lobular carcinoma (Disease Ontology:DOID:3457); pulmonary fibrosis (Disease Ontology:DOID:3770); lung adenocarcinoma (Disease Ontology:DOID:3910); papillary thyroid carcinoma (Disease Ontology:DOID:3969); renal cell carcinoma (Disease Ontology:DOID:4450); mucoepidermoid carcinoma (Disease Ontology:DOID:4531); hepatocellular carcinoma (Disease Ontology:DOID:684); hepatoblastoma (Disease Ontology:DOID:687); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); acute myeloid leukemia (Disease Ontology:DOID:9119); cleft lip (Disease Ontology:DOID:9296); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (rno:83502); (R-RNO-1474228); (R-RNO-216083); (R-RNO-351906); (R-RNO-418990); (R-RNO-5626467); (R-RNO-9764561); (R-RNO-9766229); (R-RNO-9768727); (R-RNO-9958810); (R-RNO-9958825)", "pathway_count": 11, "publication_count": 8, "publication_id_list": "10650949;12639940;29393594;32336545;32842802;33390855;34852269;37792794", "class_list": "", "function": "Air pollution-regulated E-cadherin mediates contact inhibition of proliferation via the hippo signaling pathways in emphysema., [RefSeq, PubMed]; CDH1 is Identified as A Therapeutic Target for Skin Regeneration after Mechanical Loading. Publication Status: Online-Only, [RefSeq, PubMed]; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Promotes organization of radial actin fiber structure and cellular response to contractile forces, via its interaction with AMOTL2 which facilitates anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane (By similarity). Plays a role in the early stages of desmosome cell-cell junction formation via facilitating the recruitment of DSG2 and DSP to desmosome plaques (By similarity). Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7., [UniProtKB, UniProtKB, UniProtKB]; E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production (By similarity)., [UniProtKB, UniProtKB]; E-cadherin/beta-catenin expression is conserved in human and rat erythropoiesis and marks stress erythropoiesis., [RefSeq, PubMed]; Hsc70 is required for E-cadherin expression in epithelial-like NRK-52E cells., [RefSeq, PubMed]; Radiation-induced H3K9 tri-methylation in E-cadherin promoter during lung EMT: in vitro and in vivo approaches using vanillin., [RefSeq, PubMed]", "predicted_glycosites": 11, "predicted_n_glycosites": 2, "predicted_o_glycosites": 9, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "O35794;Q9JIV9", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0045296 cadherin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0022409 positive regulation of cell-cell adhesion;GO:0042307 positive regulation of protein import into nucleus;GO:0001701 in utero embryonic development;GO:0016477 cell migration;GO:0031175 neuron projection development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9R0T4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97586-1", "uniprot_id": [ { "id": "CGRE1_RAT", "url": "https://www.uniprot.org/uniprot/P97586", "type": "external" } ], "mass": 30835.0, "length": 281, "protein_name": "Cell growth regulator with EF hand domain protein 1", "gene_name": "Cgref1", "organism": "Rat", "refseq_name": "cell growth regulator with EF hand domain protein 1", "refseq_ac": [ { "id": "NP_620787", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620787", "type": "external" } ], "gene_names_uniprotkb": "Cgref1; Cgr11", "gene_names_refseq": "Cgr11; Cgref1", "protein_names_uniprotkb": "Cell growth regulator with EF hand domain protein 1; Cell growth regulatory gene 11 protein; Hydrophobestin", "protein_names_refseq": "cell growth regulator with EF hand domain protein 1; cell growth regulatory gene 11 protein; cell growth regulatory with EF-hand domain; hydrophobestin", "tax_id": 10116, "disease": "", "pathway": " (rno:245918)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "19473726;22673903;8968090", "class_list": "", "function": "CGR11 appears to be a primary response gene expressed to moderate levels in functional p53 cells., [RefSeq, PubMed]; Cgr11 encodes a secretory protein involved in cell adhesion, [RefSeq, PubMed]; Mediates cell-cell adhesion in a calcium-dependent manner. Able to inhibit growth in several cell lines., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0007155 cell adhesion;GO:0030308 negative regulation of cell growth;GO:0051726 regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P97586-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M831-1", "uniprot_id": [ { "id": "DBND1_RAT", "url": "https://www.uniprot.org/uniprot/Q5M831", "type": "external" } ], "mass": 17329.0, "length": 160, "protein_name": "Dysbindin domain-containing protein 1", "gene_name": "Dbndd1", "organism": "Rat", "refseq_name": "dysbindin domain-containing protein 1", "refseq_ac": [ { "id": "NP_001014178", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014178", "type": "external" } ], "gene_names_uniprotkb": "Dbndd1", "gene_names_refseq": "Dbndd1; RGD1310008", "protein_names_uniprotkb": "Dysbindin domain-containing protein 1", "protein_names_refseq": "dysbindin (dystrobrevin binding protein 1) domain containing 1; dysbindin domain-containing protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:361437)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "19573021;20531346;21502952;21998198;22337344;22673903;23954924;24385487", "class_list": "", "function": "A novel cardiac role of Dysbindin in the activation of RhoA-SRF and MEK1-ERK1 signaling pathways and in the induction of cardiac hypertrophy, is reported., [RefSeq, PubMed]; Differentially regulated dysbindin isoforms are expressed in rat retina during postnatal maturation. Interestingly, we found that dysbindin is mainly localized in Muller cells., [RefSeq, PubMed]; Dysbindin and its associated complex sort cargoes from cell bodies to the synapse., [RefSeq, PubMed]; Dysbindin was expressed in the cytoplasm of neurons from epileptic specimens, and levels of dysbindin proteins were significantly increased in patients with temporal lobe epilepsy, [RefSeq, PubMed]; In primary cultured hippocampal neurons, Munc-18 is involved with dysbindin in synaptic vesicle exocytosis as a dysbindin-interacting protein., [RefSeq, PubMed]; In primary cultured neurons from rat cortex, knockdown of dysbindin-1 decreased both Coronin 1b & Rab13 mRNA levels. mRNA levels of p53 or necdin were unaltered., [RefSeq, PubMed]; Results indicate possible functions of dysbindin-1 at the postsynapse in the regulation of dendritic spine morphogenesis through the interaction with WAVE2 and Abi-1, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0009966 regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q5M831-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70569-1", "uniprot_id": [ { "id": "MYO5B_RAT", "url": "https://www.uniprot.org/uniprot/P70569", "type": "external" } ], "mass": 213721.0, "length": 1846, "protein_name": "Unconventional myosin-Vb", "gene_name": "Myo5b", "organism": "Rat", "refseq_name": "unconventional myosin-Vb", "refseq_ac": [ { "id": "NP_058779", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058779", "type": "external" } ], "gene_names_uniprotkb": "Myo5b", "gene_names_refseq": "Myo5b; Myr6", "protein_names_uniprotkb": "Unconventional myosin-Vb; Myosin heavy chain myr 6", "protein_names_refseq": "Myosin of the dilute-myosin-V family; myosin 5B; myosin heavy chain myr 6; unconventional myosin-Vb", "tax_id": 10116, "disease": "microvillus inclusion disease (Disease Ontology:DOID:0060775); progressive familial intrahepatic cholestasis (Disease Ontology:DOID:0070221)", "pathway": " (rno:25132); (R-RNO-432040)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "1469047;14766983;16338934;23770993;30545898;8855265", "class_list": "", "function": "May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis. Required for proper localization of bile salt export pump ABCB11 at the apical/canalicular plasma membrane of hepatocytes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Myosin Vb functions in traffic between peripheral and pericentrosomal compartments, [RefSeq, PubMed]; Myosin Vb has a role in in glutamate receptor GluR1 trafficking, [RefSeq, PubMed]; Rab10 interaction with myosin Vb (MYO5B) determines the formation of Rab10 carriers and is important for axon development., [RefSeq, PubMed]; Which bridges Myo5b and the membrane-bound Rab11a. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0016887 ATP hydrolysis activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0045179 apical cortex;GO:0098871 postsynaptic actin cytoskeleton;GO:0005737 cytoplasm;GO:0005903 brush border", "go_biological_process": "GO:0036466 synaptic vesicle recycling via endosome;GO:0099639 neurotransmitter receptor transport, endosome to plasma membrane;GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0032880 regulation of protein localization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P70569-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3ZB98-1", "uniprot_id": [ { "id": "BCAS1_RAT", "url": "https://www.uniprot.org/uniprot/Q3ZB98", "type": "external" } ], "mass": 62382.0, "length": 589, "protein_name": "Breast carcinoma-amplified sequence 1 homolog", "gene_name": "Bcas1", "organism": "Rat", "refseq_name": "breast carcinoma-amplified sequence 1 homolog isoform 2", "refseq_ac": [ { "id": "NP_663703", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663703", "type": "external" } ], "gene_names_uniprotkb": "Bcas1", "gene_names_refseq": "Band83; Bcas1; Pmes-2", "protein_names_uniprotkb": "Breast carcinoma-amplified sequence 1 homolog; Pmes-2; Protein whose mRNA is enriched in synaptosomes 2", "protein_names_refseq": "band 83; breast carcinoma amplified sequence 1; breast carcinoma-amplified sequence 1 homolog isoform 2; breast carcinoma-amplified sequence 1 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:246755)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12427555;16133941;22673903", "class_list": "", "function": "PMES-2 possibly modifies the cytoskeletal architecture and protein transport at the synapse and/or regulates signal transduction from the synapse to the nucleus., [RefSeq, PubMed]; Required for myelination., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1LN49;Q52KK0;Q5TLG8;Q5TLG9;Q5TLH0;Q5TLH1;Q8K4U9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0045202 synapse", "go_biological_process": "GO:0042552 myelination", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3ZB98-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XI43-1", "uniprot_id": [ { "id": "MXRA8_RAT", "url": "https://www.uniprot.org/uniprot/Q5XI43", "type": "external" } ], "mass": 42735.0, "length": 382, "protein_name": "Matrix remodeling-associated protein 8", "gene_name": "Mxra8", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mxra8", "gene_names_refseq": "", "protein_names_uniprotkb": "Matrix remodeling-associated protein 8; Limitrin", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-381426); (R-RNO-8957275)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "26479776", "class_list": "", "function": "Transmembrane protein which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3. Mediates heterophilic cell-cell interactions in vitro. Inhibits osteoclastogenesis downstream of TNFSF11/RANKL and CSF1, where it may function by attenuating signaling via integrin ITGB3 and MAP kinase p38. Plays a role in cartilage formation where it promotes proliferation and maturation of growth plate chondrocytes. Stimulates formation of primary cilia in chondrocytes. Enhances expression of genes involved in the hedgehog signaling pathway in chondrocytes, including the hedgehog signaling molecule IHH; may also promote signaling via the PTHLH/PTHrP pathway. Plays a role in angiogenesis where it suppresses migration of endothelial cells and also promotes their apoptosis. Inhibits VEGF-induced activation of AKT and p38 MAP kinase in endothelial cells. Also inhibits VTN (vitronectin)-mediated integrin ITGAV:ITGB3 signaling and activation of PTK2/FAK. May play a role in the maturation and maintenance of the blood-brain barrier., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005923 bicellular tight junction;GO:0009986 cell surface;GO:0060170 ciliary membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0030154 cell differentiation;GO:0060857 establishment of glial blood-brain barrier", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XI43-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15146-1", "uniprot_id": [ { "id": "MTAP2_RAT", "url": "https://www.uniprot.org/uniprot/P15146", "type": "external" } ], "mass": 202411.0, "length": 1861, "protein_name": "Microtubule-associated protein 2", "gene_name": "Map2", "organism": "Rat", "refseq_name": "microtubule-associated protein 2 isoform X21", "refseq_ac": [ { "id": "XP_008765430", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008765430", "type": "external" } ], "gene_names_uniprotkb": "Map2; Mtap2", "gene_names_refseq": "MAP2R; Map2; Mtap2", "protein_names_uniprotkb": "Microtubule-associated protein 2; MAP-2", "protein_names_refseq": "microtubule-associated protein 2 isoform X21", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); asphyxia neonatorum (Disease Ontology:DOID:11088); arteriovenous malformation (Disease Ontology:DOID:11294); sciatic neuropathy (Disease Ontology:DOID:11446); Lewy body dementia (Disease Ontology:DOID:12217); Huntington's disease (Disease Ontology:DOID:12858); brain ischemia (Disease Ontology:DOID:2316); temporal lobe epilepsy (Disease Ontology:DOID:3328); cerebral infarction (Disease Ontology:DOID:3526); schizophrenia (Disease Ontology:DOID:5419)", "pathway": "", "pathway_count": 0, "publication_count": 15, "publication_id_list": "11029056;15340146;17496889;18683930;19322778;2174050;22673903;2326166;2339070;2770869;29934347;38843836;8282767;9108484;9391014", "class_list": "", "function": "The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 51, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005516 calmodulin binding;GO:0008017 microtubule binding;GO:0019901 protein kinase binding;GO:0002162 dystroglycan binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule;GO:0005886 plasma membrane", "go_biological_process": "GO:0007409 axonogenesis;GO:0016358 dendrite development;GO:0031175 neuron projection development;GO:0032570 response to progesterone;GO:0032880 regulation of protein localization", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P15146-1", "record_type": "protein", "filter_code": "0000000.0000110.010000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PT87-1", "uniprot_id": [ { "id": "MYLK3_RAT", "url": "https://www.uniprot.org/uniprot/E9PT87", "type": "external" } ], "mass": 85541.0, "length": 786, "protein_name": "Myosin light chain kinase 3", "gene_name": "Mylk3", "organism": "Rat", "refseq_name": "myosin light chain kinase 3", "refseq_ac": [ { "id": "NP_001104280", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104280", "type": "external" } ], "gene_names_uniprotkb": "Mylk3", "gene_names_refseq": "MLCK; Mylk3; RGD1305801", "protein_names_uniprotkb": "Myosin light chain kinase 3; 2.7.11.18; Cardiac-MLCK; Cardiac-MyBP-C-associated Ca/CaM kinase", "protein_names_refseq": "cardiac-MLCK; cardiac-MyBP-C-associated Ca/CaM kinase; myosin light chain kinase 3; putative myosin light chain kinase 3", "tax_id": 10116, "disease": "", "pathway": " (rno:291926)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17885681;20615916;22673903;25451385;26809094;28300565", "class_list": "", "function": "Calmodulin-dependent kinase that phosphorylates MYL2 in vitro (PubMed:17885681). Promotes sarcomere formation in cardiomyocytes. Increases cardiomyocyte contractility., [UniProtKB, PubMed, PubMed]; In conclusion, in addition to MLCK, CaMKII phosphorylates RLC in cardiomyocytes., [RefSeq, PubMed]; Ischemia/reperfusion-activated MMP-2 leads to the degradation of cardiac MLCK., [RefSeq, PubMed]; We found that a rounded shape with high cortical tension depends on MLCK and ROCK, whereas in cells with an elongated shape, MLCK is the primary protein responsible for cell spreading. Further, in cells with a slow and directionally persistent motility, MLCK predominates, while rapid and erratic movement is ROCK-dependent, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8WE96", "ec_number_list": [ { "id": "2.7.11.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.18", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004683 calcium/calmodulin-dependent protein kinase activity;GO:0004687 myosin light chain kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0007165 signal transduction;GO:0055003 cardiac myofibril assembly;GO:1905075 positive regulation of tight junction disassembly;GO:0045214 sarcomere organization;GO:0071347 cellular response to interleukin-1", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "E9PT87-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62598-1", "uniprot_id": [ { "id": "DSPP_RAT", "url": "https://www.uniprot.org/uniprot/Q62598", "type": "external" } ], "mass": 70179.0, "length": 687, "protein_name": "Dentin sialophosphoprotein", "gene_name": "Dspp", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Dspp; Rdsp2", "gene_names_refseq": "", "protein_names_uniprotkb": "Dentin sialophosphoprotein; DPP; Dentin phosphophoryn", "protein_names_refseq": "", "tax_id": 10116, "disease": "osteoporosis (Disease Ontology:DOID:11476); periodontal disease (Disease Ontology:DOID:3388); dentinogenesis imperfecta (Disease Ontology:DOID:4154)", "pathway": " (R-RNO-3000178)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10403786;10978503;11042175;15308669;8106414;8702961;9395101", "class_list": "", "function": "DSP may be an important factor in dentinogenesis. DPP may bind high amount of calcium and facilitate initial mineralization of dentin matrix collagen as well as regulate the size and shape of the crystals., [UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 6, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "P70578;Q9R057", "ec_number_list": [], "go_molecular_function": "GO:0005518 collagen binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0031012 extracellular matrix", "go_biological_process": "GO:0071559 response to transforming growth factor beta;GO:0097187 dentinogenesis;GO:2001054 negative regulation of mesenchymal cell apoptotic process;GO:0048820 hair follicle maturation;GO:1903011 negative regulation of bone development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q62598-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06518-1", "uniprot_id": [ { "id": "NOS2_RAT", "url": "https://www.uniprot.org/uniprot/Q06518", "type": "external" } ], "mass": 130628.0, "length": 1147, "protein_name": "Nitric oxide synthase, inducible", "gene_name": "Nos2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Nos2", "gene_names_refseq": "", "protein_names_uniprotkb": "Nitric oxide synthase, inducible; 1.14.13.39; Inducible NO synthase; Inducible NOS; NOS type II; Peptidyl-cysteine S-nitrosylase NOS2; iNOS", "protein_names_refseq": "", "tax_id": 10116, "disease": "lissencephaly (Disease Ontology:DOID:0050453); inflammatory bowel disease (Disease Ontology:DOID:0050589); obstructive sleep apnea (Disease Ontology:DOID:0050848); stroke (Disease Ontology:DOID:0051061); colitis (Disease Ontology:DOID:0060180); respiratory allergy (Disease Ontology:DOID:0060496); mucositis (Disease Ontology:DOID:0080178); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); asthma, nasal polyps, and aspirin intolerance (Disease Ontology:DOID:0111579); sleeping sickness (Disease Ontology:DOID:10112); pleurisy (Disease Ontology:DOID:10247); asbestosis (Disease Ontology:DOID:10320); Alzheimer's disease (Disease Ontology:DOID:10652); renal hypertension (Disease Ontology:DOID:1073); otitis media (Disease Ontology:DOID:10754); hypertension (Disease Ontology:DOID:10763); essential hypertension (Disease Ontology:DOID:10825); gastroschisis (Disease Ontology:DOID:11044); meconium aspiration syndrome (Disease Ontology:DOID:11049); pneumocystosis (Disease Ontology:DOID:11339); pulmonary edema (Disease Ontology:DOID:11396); diabetic angiopathy (Disease Ontology:DOID:11713); allergic disease (Disease Ontology:DOID:1205); Lewy body dementia (Disease Ontology:DOID:12217); primary biliary cholangitis (Disease Ontology:DOID:12236); malaria (Disease Ontology:DOID:12365); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); dilated cardiomyopathy (Disease Ontology:DOID:12930); retinopathy of prematurity (Disease Ontology:DOID:13025); dementia (Disease Ontology:DOID:1307); lung cancer (Disease Ontology:DOID:1324); pulmonary sarcoidosis (Disease Ontology:DOID:13406); hepatic encephalopathy (Disease Ontology:DOID:13413); interstitial cystitis (Disease Ontology:DOID:13949); anterior uveitis (Disease Ontology:DOID:1407); toxic shock syndrome (Disease Ontology:DOID:14115); hypothyroidism (Disease Ontology:DOID:1459); cystic fibrosis (Disease Ontology:DOID:1485); pancreatic cancer (Disease Ontology:DOID:1793); epilepsy (Disease Ontology:DOID:1826); impotence (Disease Ontology:DOID:1875); hepatitis (Disease Ontology:DOID:2237); colon adenocarcinoma (Disease Ontology:DOID:234); bronchiolitis obliterans (Disease Ontology:DOID:2799); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); coronary artery disease (Disease Ontology:DOID:3393); middle cerebral artery infarction (Disease Ontology:DOID:3525); allergic rhinitis (Disease Ontology:DOID:4481); rhinitis (Disease Ontology:DOID:4483); uremia (Disease Ontology:DOID:4676); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); cholangiocarcinoma (Disease Ontology:DOID:4947); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); paraplegia (Disease Ontology:DOID:607); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); abdominal aortic aneurysm (Disease Ontology:DOID:7693); extrinsic allergic alveolitis (Disease Ontology:DOID:841); lung disease (Disease Ontology:DOID:850); alcoholic gastritis (Disease Ontology:DOID:8680); nasopharynx carcinoma (Disease Ontology:DOID:9261); type 2 diabetes mellitus (Disease Ontology:DOID:9352); allergic asthma (Disease Ontology:DOID:9415); pulmonary emphysema (Disease Ontology:DOID:9675); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24599); (R-RNO-1222556); (R-RNO-392154); (R-RNO-9033241)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "16641100;7513765;7516453;7519448;7540573;7680561;7682072;7693462;8913516;9535415;9851365", "class_list": "", "function": "Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in inflammation, enhances the synthesis of pro-inflammatory mediators such as IL6 and IL8., [UniProtKB, UniProtKB, UniProtKB]; Produces nitric oxide (NO) which is a messenger molecule with diverse functions., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 70, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35765;O35766;O60591;O60604;P97774;Q63267;Q64005;Q64558", "ec_number_list": [ { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "1.2.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "1.4.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" }, { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "5.1.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "4.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.9", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" } ], "go_molecular_function": "GO:0004517 nitric-oxide synthase activity;GO:0034617 tetrahydrobiopterin binding;GO:0003779 actin binding;GO:0005516 calmodulin binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005777 peroxisome;GO:0005829 cytosol", "go_biological_process": "GO:0071461 cellular response to redox state;GO:0006954 inflammatory response;GO:0010629 negative regulation of gene expression;GO:0018119 peptidyl-cysteine S-nitrosylation;GO:0032496 response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q06518-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23348-1", "uniprot_id": [ { "id": "B3A3_RAT", "url": "https://www.uniprot.org/uniprot/P23348", "type": "external" } ], "mass": 135407.0, "length": 1227, "protein_name": "Anion exchange protein 3", "gene_name": "Slc4a3", "organism": "Rat", "refseq_name": "anion exchange protein 3", "refseq_ac": [ { "id": "NP_058745", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058745", "type": "external" } ], "gene_names_uniprotkb": "Slc4a3; Ae3; B3rp3", "gene_names_refseq": "Ae3; Aep3; Slc4a3", "protein_names_uniprotkb": "Anion exchange protein 3; AE 3; Anion exchanger 3; B3RP-3; Band 3-related protein 3; Neuronal band 3-like protein; Solute carrier family 4 member 3", "protein_names_refseq": "AE 3; B3RP-3; Solute carrier family 4, member 3, anion exchange protein 3; anion exchange protein 3; anion exchanger 3; band 3-related protein 3; neuronal band 3-like protein; solute carrier family 4 (anion exchanger), member 3", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); short QT syndrome (Disease Ontology:DOID:0050793); catecholaminergic polymorphic ventricular tachycardia (Disease Ontology:DOID:0060674); Graves' disease (Disease Ontology:DOID:12361); anemia (Disease Ontology:DOID:2355); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (rno:24781); (R-RNO-425381)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10548554;17652430;21608017;22673903;22693949;2294114;28677776", "class_list": "", "function": "AE(3) is required for SQS to inhibit sI/R-induced elevation of [Cl(-)](i), which subsequently inhibited sI/R-induced Ca(2+) overload, ROS production, and cell apoptosis., [RefSeq, PubMed]; Coexpression of carbonic anhydrase IX and SLC4A3 activated SLC4A3 mediated transport., [RefSeq, PubMed]; Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane. May be involved in the regulation of intracellular pH, and the modulation of cardiac action potential (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; The increase in AE(3) expression occurring during SQS pretreatment was almost completely abolished., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0022857 transmembrane transporter activity;GO:0015106 bicarbonate transmembrane transporter activity;GO:0140900 chloride:bicarbonate antiporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0061337 cardiac conduction;GO:0015701 bicarbonate transport;GO:0051453 regulation of intracellular pH;GO:0098901 regulation of cardiac muscle cell action potential", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P23348-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62908-1", "uniprot_id": [ { "id": "CSRP2_RAT", "url": "https://www.uniprot.org/uniprot/Q62908", "type": "external" } ], "mass": 20940.0, "length": 193, "protein_name": "Cysteine and glycine-rich protein 2", "gene_name": "Csrp2", "organism": "Rat", "refseq_name": "cysteine and glycine-rich protein 2", "refseq_ac": [ { "id": "NP_803174", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803174", "type": "external" } ], "gene_names_uniprotkb": "Csrp2; Smlim", "gene_names_refseq": "Csrp2; SmLIM", "protein_names_uniprotkb": "Cysteine and glycine-rich protein 2; CRP2; Cysteine-rich protein 2; SmLIM; Smooth muscle cell LIM protein", "protein_names_refseq": "CRP2; LIM/double zinc-finger protein; cysteine and glycine-rich protein 2; cysteine-rich protein 2; smooth muscle cell LIM protein", "tax_id": 10116, "disease": "", "pathway": " (rno:29317)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15219810;17185421;18387947;19364329;8626582", "class_list": "", "function": "CRP2 acted as a potent transcription coadaptor that remodeled silent cardiac myocyte chromatin and directed serum response factor-dependent smooth muscle gene activity., [RefSeq, PubMed]; Could play a role in neuronal development., [UniProtKB, UniProtKB]; Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system., [UniProtKB]; In rats, estrogen was found to up-regulate SmLIM genes in smooth muscle vascular cells., [RefSeq, PubMed]; Results demonstrated that in undifferentiated olfactory precursor cells Csrp2 was distributed both in the nucleus and the cytoplasm, whereas CRIP2 was predominantly localized in the cytoplasm., [RefSeq, PubMed]; TGFbeta activates ATF2 phosphorylation and Csrp2 gene expression via a CRE promoter element., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008307 structural constituent of muscle;GO:0042805 actinin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0030018 Z disc", "go_biological_process": "GO:0045214 sarcomere organization;GO:0045445 myoblast differentiation;GO:0060537 muscle tissue development;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q62908-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35179-1", "uniprot_id": [ { "id": "SH3G2_RAT", "url": "https://www.uniprot.org/uniprot/O35179", "type": "external" } ], "mass": 39899.0, "length": 352, "protein_name": "Endophilin-A1", "gene_name": "Sh3gl2", "organism": "Rat", "refseq_name": "endophilin-A1", "refseq_ac": [ { "id": "NP_446387", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446387", "type": "external" } ], "gene_names_uniprotkb": "Sh3gl2; Sh3d2a; Sh3p4", "gene_names_refseq": "Sh3d2a; Sh3gl2; Sh3p4", "protein_names_uniprotkb": "Endophilin-A1; Endophilin-1; SH3 domain protein 2A; SH3 domain-containing GRB2-like protein 2; SH3p4", "protein_names_refseq": "SH3 domain protein 2A; SH3 domain-containing GRB2-like 2; SH3 domain-containing GRB2-like protein 2; SH3-domain GRB2-like 2; endophilin-1; endophilin-A1", "tax_id": 10116, "disease": "", "pathway": " (rno:116743); (R-RNO-177504); (R-RNO-182971); (R-RNO-2132295); (R-RNO-432720); (R-RNO-432722); (R-RNO-437239); (R-RNO-6807004); (R-RNO-8856825); (R-RNO-8856828)", "pathway_count": 10, "publication_count": 12, "publication_id_list": "11384986;11604418;15066995;16319893;16763557;16763559;26854628;28933693;31059028;8889548;9238017;9341169", "class_list": "", "function": "A potential role for endophilin 1 in Abetainduced postsynaptic dysfunction has been identified, indicating a possible direction for the prevention of postsynaptic dysfunction in cognitive impairment and suggesting that endophilin may be a potential target for the clinical treatment of Alzheimer's disease., [RefSeq, PubMed]; Implicated in endocytosis (PubMed:11604418, PubMed:16763559). Involved ultrafast endocytosis, by mediating, in a first step, neck formation and in a second step, aids in the removal of clathrin coats from the regenerated vesicles (By similarity). May recruit other proteins to membranes with high curvature (By similarity) (PubMed:11604418, PubMed:16763559). Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; These data suggested a role of EndoII in protecting BASMCs apoptosis induced by H2O2, possibly by inhibiting the addressing of Bax to mitochondria. Targeting on EndoII may be a new strategy to treat apoptosis-associated diseases., [RefSeq, PubMed]; Together, these observations suggest that while endophilin helps shape endocytic tubules and recruit dynamin to endocytic sites, it can also block membrane fission when present in excess by inhibiting inter-dynamin interactions. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0044325 transmembrane transporter binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0097749 membrane tubulation;GO:1990416 cellular response to brain-derived neurotrophic factor stimulus;GO:0097753 membrane bending;GO:0010629 negative regulation of gene expression;GO:0031175 neuron projection development", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O35179-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35274-1", "uniprot_id": [ { "id": "NEB2_RAT", "url": "https://www.uniprot.org/uniprot/O35274", "type": "external" } ], "mass": 89646.0, "length": 817, "protein_name": "Neurabin-2", "gene_name": "Ppp1r9b", "organism": "Rat", "refseq_name": "neurabin-2", "refseq_ac": [ { "id": "NP_445926", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445926", "type": "external" } ], "gene_names_uniprotkb": "Ppp1r9b; Spino", "gene_names_refseq": "Neb2; Ppp1r9b", "protein_names_uniprotkb": "Neurabin-2; Neurabin-II; Neural tissue-specific F-actin-binding protein II; PP1bp134; Protein phosphatase 1 regulatory subunit 9B; Spinophilin; p130", "protein_names_refseq": "PP1bp134; neurabin-2; neurabin-II; neural tissue-specific F-actin-binding protein II; nuerabin 2; p130; spinophilin", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); Parkinson's disease (Disease Ontology:DOID:14330); schizophrenia (Disease Ontology:DOID:5419); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:84686)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10194355;10391935;10514494;10585469;11154706;12417592;12531897;15135218;15228588;15514983;15743906;15793568;20305656;22673903;24069387;25750125;27890541;29383693;9275233;9452470", "class_list": "", "function": "Aging-induced proteostatic changes in the rat hippocampus identify ARP3, NEB2 and BRAG2 as a molecular circuitry for cognitive impairment. Publication Status: Online-Only, [RefSeq, PubMed]; At 1 d after acute foodshake-stress Spinophilin was significantly increased in At 1 d after desipramine-treated animals as compared to vehicle-treated animals., [RefSeq, PubMed]; PP1 bound on spinophilin, a close homolog of neurabin and another major synaptic PP1 anchoring protein, does not play a role in long term depression [LTD] induction, which suggests that neurabin plays a privileged role in nanodomain targeting of PP1 in LTD induction., [RefSeq, PubMed]; Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Plays a role in regulation of G protein-coupled receptor signaling, including dopamine D2 receptors and alpha-adrenergic receptors. May establish a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Binds to ADRA1B and RGS2 and mediates regulation of ADRA1B signaling. May confer to Rac signaling specificity by binding to both, RacGEFs and Rac effector proteins. Probably regulates p70 S6 kinase activity by forming a complex with TIAM1. Required for hepatocyte growth factor (HGF)-induced cell migration (By similarity)., [UniProtKB, PubMed, PubMed]; The guanine nucleotide exchange factor (GEF) Asef2 promotes dendritic spine formation via Rac activation and spinophilin-dependent targeting., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 12, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0004672 protein kinase activity;GO:0051015 actin filament binding;GO:0044325 transmembrane transporter binding;GO:0019900 kinase binding", "go_cellular_component": "GO:1990780 cytoplasmic side of dendritic spine plasma membrane;GO:0098978 glutamatergic synapse;GO:0098890 extrinsic component of postsynaptic membrane;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0003006 developmental process involved in reproduction;GO:1903119 protein localization to actin cytoskeleton;GO:1904372 positive regulation of protein localization to actin cortical patch;GO:1904386 response to L-phenylalanine derivative;GO:0060179 male mating behavior", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "O35274-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18125-1", "uniprot_id": [ { "id": "CP7A1_RAT", "url": "https://www.uniprot.org/uniprot/P18125", "type": "external" } ], "mass": 56883.0, "length": 503, "protein_name": "Cytochrome P450 7A1", "gene_name": "Cyp7a1", "organism": "Rat", "refseq_name": "cytochrome P450 7A1", "refseq_ac": [ { "id": "NP_037074", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037074", "type": "external" } ], "gene_names_uniprotkb": "Cyp7a1; Cyp7", "gene_names_refseq": "CHAP; CYP7S1; CYP7; Cyp7a1", "protein_names_uniprotkb": "Cytochrome P450 7A1; 1.14.14.23; 1.14.14.26; 24-hydroxycholesterol 7-alpha-hydroxylase; CYPVII; Cholesterol 7-alpha-hydroxylase; Cholesterol 7-alpha-monooxygenase", "protein_names_refseq": "24-hydroxycholesterol 7-alpha-hydroxylase; CYPVII; cholesterol 7-alpha-hydroxylase; cholesterol 7-alpha-monooxygenase; cytochrome P450 (cholesterol hydroxylase 7 alpha); cytochrome P450 7A1; cytochrome P450, 7a1; cytochrome P450, family 7, subfamily a, polypeptide 1", "tax_id": 10116, "disease": "metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); progressive myoclonus epilepsy 1A (Disease Ontology:DOID:0111452); morbid obesity (Disease Ontology:DOID:11981); alcoholic hepatitis (Disease Ontology:DOID:12351); cholestasis (Disease Ontology:DOID:13580); extrahepatic cholestasis (Disease Ontology:DOID:13619); Unverricht-Lundborg syndrome (Disease Ontology:DOID:3535)", "pathway": " (rno:25428); (R-RNO-192105); (R-RNO-193368); (R-RNO-193807); (R-RNO-211976)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "11278771;1420318;1693613;1694852;2007596;2261433;2335522;2806567;31288013;8021257", "class_list": "", "function": "A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (PubMed:1694852, PubMed:2335522). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:1694852, PubMed:2335522). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis. Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha position of cholesterol, a rate-limiting step in cholesterol catabolism and bile acid biosynthesis (PubMed:1694852, PubMed:2335522). 7-alpha hydroxylates several oxysterols, including 4beta-hydroxycholesterol and 24-hydroxycholesterol. Catalyzes the oxidation of the 7,8 double bond of 7-dehydrocholesterol and lathosterol with direct and predominant formation of the 7-keto derivatives (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; The increased CDCAs concentrations activated Fxr-Fgf15 pathway in ileum to result in the mRNA expression of Cyp7a1 in liver down-regulation, which inhibited cholesterol metabolizing into primary BAs to contribute to the cholesterol level increase in liver tissue in HFD-induced obesity rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P51543", "ec_number_list": [ { "id": "1.14.14.23", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.23", "type": "external" }, { "id": "1.14.14.26", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.26", "type": "external" }, { "id": "1.14.14.29", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.29", "type": "external" } ], "go_molecular_function": "GO:0008123 cholesterol 7-alpha-monooxygenase activity;GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0033782 24S-hydroxycholesterol 7-alpha-hydroxylase activity", "go_cellular_component": "GO:0043231 intracellular membrane-bounded organelle;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0070857 regulation of bile acid biosynthetic process;GO:0006699 bile acid biosynthetic process;GO:0045471 response to ethanol;GO:0045717 negative regulation of fatty acid biosynthetic process;GO:0071333 cellular response to glucose stimulus", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P18125-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19335-1", "uniprot_id": [ { "id": "MYF6_RAT", "url": "https://www.uniprot.org/uniprot/P19335", "type": "external" } ], "mass": 26987.0, "length": 242, "protein_name": "Myogenic factor 6", "gene_name": "Myf6", "organism": "Rat", "refseq_name": "myogenic factor 6", "refseq_ac": [ { "id": "NP_037304", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037304", "type": "external" } ], "gene_names_uniprotkb": "Myf6; Mrf4", "gene_names_refseq": "MRF4AA; Myf6", "protein_names_uniprotkb": "Myogenic factor 6; Muscle-specific regulatory factor 4; Myf-6", "protein_names_refseq": "Myogenic factor 6 (herculin); muscle-specific regulatory factor 4; myf-6; myogenic factor 6", "tax_id": 10116, "disease": "Duchenne muscular dystrophy (Disease Ontology:DOID:11723); musculoskeletal system disease (Disease Ontology:DOID:17); congenital structural myopathy (Disease Ontology:DOID:422)", "pathway": " (rno:25714); (R-RNO-525793)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "1639267;22464481;2560751;27484840;8413199;9234731", "class_list": "", "function": "Decreased myostatin expression combined with significant muscle atrophy is observed in spontaneously hypertensive rats (SHR) with heart failure; MRF4 levels positively correlate with type I MyHC isoform., [RefSeq, PubMed]; Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein. May play a role in controlling terminal differentiation events., [UniProtKB]; MRF4 acts by stabilizing a repressor complex that controls MEF2 activity. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0043403 skeletal muscle tissue regeneration;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0001756 somitogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P19335-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20817-1", "uniprot_id": [ { "id": "CP4AE_RAT", "url": "https://www.uniprot.org/uniprot/P20817", "type": "external" } ], "mass": 58232.0, "length": 507, "protein_name": "Cytochrome P450 4A14", "gene_name": "Cyp4a14", "organism": "Rat", "refseq_name": "cytochrome P450 4A14", "refseq_ac": [ { "id": "NP_786936", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786936", "type": "external" } ], "gene_names_uniprotkb": "Cyp4a14; Cyp4a-3; Cyp4a3", "gene_names_refseq": "CYPIVA3; Cyp4a14; Cyp4a3", "protein_names_uniprotkb": "Cytochrome P450 4A14; 1.14.14.80; CYPIVA14; Cytochrome P450-LA-omega 3; Lauric acid omega-hydroxylase; Long-chain fatty acid omega-monooxygenase", "protein_names_refseq": "CYPIVA14; P450-LA-omega 3; cytochrome P450 4A14; cytochrome P450 4A3; cytochrome P450, family 4, subfamily a, polypeptide 14; cytochrome P450-LA-omega 3; long-chain fatty acid omega-monooxygenase", "tax_id": 10116, "disease": "", "pathway": " (rno:298423); (R-RNO-211935); (R-RNO-211958); (R-RNO-211979); (R-RNO-2142691)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "10869363;11139583;11821421;22673903;2766933;28270609;3365247", "class_list": "", "function": "A cytochrome P450 monooxygenase that catalyzes omega and omega-1 hydroxylation of saturated fatty acids. Exhibits preferential omega versus omega-1 regioselectivity and (R) versus (S) stereoselectivity for hydroxylation of dodecanoic (lauric) acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase)., [UniProtKB, PubMed]; This study provides a link between CYP4A14 and NAFLD. Overexpression of CYP4A14 promotes, whereas gene disruption of CYP4A14 attenuates, HFD- and MCD-induced liver lipid accumulation. Ablation of CYP4A14 gene markedly attenuates liver damage, inflammation, and fibrosis in MCD-induced NASH. Erratum:[Proc Natl Acad Sci U S A. 2023 Oct 17;120(42):e2315591120. doi: 10.1073/pnas.2315591120. PMID: 37824533], [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.14.80", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.80", "type": "external" }, { "id": "1.14.14.79", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.79", "type": "external" }, { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" }, { "id": "1.14.14.94", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.94", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0018685 alkane 1-monooxygenase activity;GO:0008391 arachidonate monooxygenase activity;GO:0102033 long-chain fatty acid omega-hydroxylase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:1904681 response to 3-methylcholanthrene;GO:0046456 icosanoid biosynthetic process;GO:0001822 kidney development;GO:0043651 linoleic acid metabolic process;GO:0019369 arachidonate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P20817-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21994-1", "uniprot_id": [ { "id": "CXB2_RAT", "url": "https://www.uniprot.org/uniprot/P21994", "type": "external" } ], "mass": 26451.0, "length": 226, "protein_name": "Gap junction beta-2 protein", "gene_name": "Gjb2", "organism": "Rat", "refseq_name": "gap junction beta-2 protein", "refseq_ac": [ { "id": "NP_001004099", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004099", "type": "external" } ], "gene_names_uniprotkb": "Gjb2; Cxn-26", "gene_names_refseq": "CXN-26; Cx26; Cxne; Gjb2", "protein_names_uniprotkb": "Gap junction beta-2 protein; Connexin-26; Cx26", "protein_names_refseq": "connexin e; gap junction beta-2 protein; gap junction channel protein connexin 26; gap junction membrane channel protein beta 2", "tax_id": 10116, "disease": "Bart-Pumphrey syndrome (Disease Ontology:DOID:0050658); autosomal dominant keratitis-ichthyosis-deafness syndrome (Disease Ontology:DOID:0060871); autosomal recessive nonsyndromic deafness 1A (Disease Ontology:DOID:0110475); autosomal dominant nonsyndromic deafness 3A (Disease Ontology:DOID:0110564); Vohwinkel syndrome (Disease Ontology:DOID:0111339); palmoplantar keratoderma-deafness syndrome (Disease Ontology:DOID:0111505); sensorineural hearing loss (Disease Ontology:DOID:10003); urethral obstruction (Disease Ontology:DOID:12577); extrahepatic cholestasis (Disease Ontology:DOID:13619); ischemia (Disease Ontology:DOID:326); lung adenocarcinoma (Disease Ontology:DOID:3910); hepatocellular carcinoma (Disease Ontology:DOID:684); autoimmune thyroiditis (Disease Ontology:DOID:7188)", "pathway": " (rno:394266); (R-RNO-190872)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "19864490;2557354;27053364;27143357;27816814;2823143;29207085;33171391", "class_list": "", "function": "Heart and liver connexin expression related to the first stage of aging: A study on naturally aged animals., [RefSeq, PubMed]; SP1 and TFAP2A regulate Gjb2 promoter activity during epididymal differentiation in rat., [RefSeq, PubMed]; Structural component of gap junctions. Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane. Small molecules and ions diffuse from one cell to a neighboring cell via the central pore., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Structural component of the gap junction, a specialized intercellular structure consisting of a cluster of closely packed pairs of transmembrane channels, the connexons, that allow passage of small molecules and electrical signals between neighboring cells. Forms homotypic and heterotypic channels gated by transjunctional voltage. Involved in intercellular innate immune signaling. Mediates translocation of 2',3'-cGAMP and 2',5'-oligoadenylates (2-5A) second messengers from virus-infected cells to macrophages and uninfected neighboring cells to propagate and amplify the antiviral immune response., [UniProtKB, UniProtKB]; Supplementation with vitamin E, with or without caloric restriction, upregulated the mRNA expression of Cx26, N-cad, E-cad and genes involved in cholesterol metabolism, suggesting the maintenance of hepatic homeostasis., [RefSeq, PubMed]; The role of the charged residues at the end of TM-1 in voltage sensing in Cx26, Cx46, and Cx50., [RefSeq, PubMed]; These results demonstrate that chronic prenatal hypoxia caused hearing impairment, and suggest that promoter region hypermethylation and expression downregulation of Cx26 underlie the mechanism of action, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:1903763 gap junction channel activity involved in cell communication by electrical coupling;GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030054 cell junction;GO:0048471 perinuclear region of cytoplasm;GO:0097449 astrocyte projection;GO:0044297 cell body", "go_biological_process": "GO:0002931 response to ischemia;GO:0007267 cell-cell signaling;GO:0032496 response to lipopolysaccharide;GO:0055085 transmembrane transport;GO:0071377 cellular response to glucagon stimulus", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P21994-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70526-1", "uniprot_id": [ { "id": "OLF1_RAT", "url": "https://www.uniprot.org/uniprot/P70526", "type": "external" } ], "mass": 35537.0, "length": 314, "protein_name": "Olfactory receptor 1", "gene_name": "Olfr1; Olr1469", "organism": "Rat", "refseq_name": "olfactory receptor 1", "refseq_ac": [ { "id": "NP_997692", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997692", "type": "external" } ], "gene_names_uniprotkb": "Olfr1; Olr1469; Olr1469; Or1e16", "gene_names_refseq": "Olfr1; Olr1469", "protein_names_uniprotkb": "Olfactory receptor 1; Olfactory receptor 1469; Olfactory receptor HGL-SP1; Olfactory receptor OR5; Olfactory receptor-like protein I54", "protein_names_refseq": "olfactory receptor 1-like; olfactory receptor 1469; olfactory receptor 1; olfactory receptor HGL-SP1; olfactory receptor OR5; olfactory receptor-like protein I54", "tax_id": 10116, "disease": "", "pathway": " (rno:404976)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1840504;2164471;7678922;9858390", "class_list": "", "function": "Odorant receptor. Activated by a lily-derived aldehyde as well as other odorants. May signal through an inositol 1,4,5-trisphosphate (IP3) second messenger system., [UniProtKB, PubMed, PubMed]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q04059;Q9QWW7", "ec_number_list": [], "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0038022 G protein-coupled olfactory receptor activity;GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P70526-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07120-1", "uniprot_id": [ { "id": "GFI1_RAT", "url": "https://www.uniprot.org/uniprot/Q07120", "type": "external" } ], "mass": 45858.0, "length": 423, "protein_name": "Zinc finger protein Gfi-1", "gene_name": "Gfi1", "organism": "Rat", "refseq_name": "zinc finger protein Gfi-1", "refseq_ac": [ { "id": "NP_036698", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036698", "type": "external" } ], "gene_names_uniprotkb": "Gfi1; Gfi-1", "gene_names_refseq": "Gfi1", "protein_names_uniprotkb": "Zinc finger protein Gfi-1; Growth factor independent protein 1", "protein_names_refseq": "Growth factor independent-1; growth factor independent 1 transcription repressor; growth factor independent protein 1; zinc finger protein Gfi-1", "tax_id": 10116, "disease": "severe congenital neutropenia (Disease Ontology:DOID:0050590); myelodysplastic syndrome (Disease Ontology:DOID:0050908); severe congenital neutropenia 2 (Disease Ontology:DOID:0112131); leukemia (Disease Ontology:DOID:1240); alcohol use disorder (Disease Ontology:DOID:1574); myelodysplastic/myeloproliferative neoplasm (Disease Ontology:DOID:4972); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (rno:24388)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12721361;20153336;20190815;22673903;8441411", "class_list": "", "function": "This protein targets a subset of genes differentiating hematopoietic lineages and plays a role in the hierarchy of factors governing stem cell differentiation. Erratum:[Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):16134], [RefSeq, PubMed]; Transcription repressor essential for hematopoiesis (By similarity). Functions in a cell-context and development-specific manner (By similarity). Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes (By similarity). Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (By similarity). Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development (By similarity). Inhibits SPI1 transcriptional activity at macrophage-specific genes, repressing macrophage differentiation of myeloid progenitor cells and promoting granulocyte commitment (By similarity). Mediates, together with U2AF1L4, the alternative splicing of CD45 and controls T-cell receptor signaling (By similarity). Regulates the endotoxin-mediated Toll-like receptor (TLR) inflammatory response by antagonizing RELA (By similarity). Cooperates with CBFA2T2 to regulate ITGB1-dependent neurite growth (By similarity). Controls cell-cycle progression by repressing CDKNIA/p21 transcription in response to TGFB1 via recruitment of GFI1 by ZBTB17 to the CDKNIA/p21 and CDKNIB promoters (PubMed:20190815). Required for the maintenance of inner ear hair cells (By similarity). In addition to its role in transcription, acts as a substrate adapter for PRMT1 in the DNA damage response: facilitates the recognition of TP53BP1 and MRE11 substrates by PRMT1, promoting their methylation and the DNA damage response (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0017053 transcription repressor complex;GO:0016604 nuclear body;GO:0016363 nuclear matrix", "go_biological_process": "GO:0042491 inner ear auditory receptor cell differentiation;GO:0010957 negative regulation of vitamin D biosynthetic process;GO:0070105 positive regulation of interleukin-6-mediated signaling pathway;GO:0007638 mechanosensory behavior;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q07120-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q10746-1", "uniprot_id": [ { "id": "CXCL3_RAT", "url": "https://www.uniprot.org/uniprot/Q10746", "type": "external" } ], "mass": 11109.0, "length": 101, "protein_name": "C-X-C motif chemokine 3", "gene_name": "Cxcl3", "organism": "Rat", "refseq_name": "C-X-C motif chemokine 3 precursor", "refseq_ac": [ { "id": "NP_001381519", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001381519", "type": "external" } ], "gene_names_uniprotkb": "Cxcl3; Cinc2", "gene_names_refseq": "Cinc-2; Cinc2; Cxcl3; Gm1960", "protein_names_uniprotkb": "C-X-C motif chemokine 3; CINC-2; Cytokine-induced neutrophil chemoattractant 2; MIP2-alpha/beta; Macrophage inflammatory protein 2-alpha/beta", "protein_names_refseq": "C-X-C motif chemokine 3 precursor; C-X-C motif chemokine 3; MIP2-alpha/beta; chemokine (C-X-C motif) ligand 3; cytokine-induced neutrophil chemoattractant 2; macrophage inflammatory protein 2-alpha/beta", "tax_id": 10116, "disease": "Coronavirus infectious disease (Disease Ontology:DOID:0080599); COVID-19 (Disease Ontology:DOID:0080600); common cold (Disease Ontology:DOID:10459); cystic fibrosis (Disease Ontology:DOID:1485); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); bacterial pneumonia (Disease Ontology:DOID:874); hyperhomocysteinemia (Disease Ontology:DOID:9279)", "pathway": " (rno:171551); (R-RNO-380108); (R-RNO-418594)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "20602290;27967265;31616413;37194082;8043001;8471066;8607872;9576061", "class_list": "", "function": "CINC-2 and miR-199a-5p in EVs secreted by transplanted Thy1[+] cells activate hepatocytic progenitor cell growth in rat liver regeneration. Publication Status: Online-Only, [RefSeq, PubMed]; Ligand for CXCR2 (By similarity). Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion., [UniProtKB, PubMed, PubMed]; Pharmacological Blockade of Spinal CXCL3/CXCR2 Signaling by NVP CXCR2 20, a Selective CXCR2 Antagonist, Reduces Neuropathic Pain Following Peripheral Nerve Injury. Publication Status: Online-Only, [RefSeq, PubMed]; The decreased serum concentration of CINC-1 as neuroprotective agent and increased CINC-2alpha in late stage of Morris hepatoma may be considered for their contribution to cerebellar degeneration., [RefSeq, PubMed]; This study shows elevated expression of CINC-2 at the site of inflammation as well as their significant reflection in the circulation, thereby suggesting their frontline role in carrageenan-induced acute inflammation, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q10747;Q5CZ55;Q9EP62", "ec_number_list": [], "go_molecular_function": "GO:0008009 chemokine activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006954 inflammatory response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0032496 response to lipopolysaccharide;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0071222 cellular response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q10746-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3MIF2-1", "uniprot_id": [ { "id": "LMBL2_RAT", "url": "https://www.uniprot.org/uniprot/Q3MIF2", "type": "external" } ], "mass": 78967.0, "length": 703, "protein_name": "Lethal(3)malignant brain tumor-like protein 2", "gene_name": "L3mbtl2", "organism": "Rat", "refseq_name": "lethal(3)malignant brain tumor-like protein 2", "refseq_ac": [ { "id": "NP_001028867", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028867", "type": "external" } ], "gene_names_uniprotkb": "L3mbtl2", "gene_names_refseq": "L3mbtl2", "protein_names_uniprotkb": "Lethal(3)malignant brain tumor-like protein 2; L(3)mbt-like protein 2", "protein_names_refseq": "L3MBTL2 polycomb repressive complex 1 subunit; l(3)mbt-like 2 protein; l(3)mbt-like protein 2; lethal(3)malignant brain tumor-like 2 protein; lethal(3)malignant brain tumor-like protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:300320); (R-RNO-4551638); (R-RNO-8953750)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27' (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0042393 histone binding;GO:1990841 promoter-specific chromatin binding;GO:0140005 histone H4K20me2 reader activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0010629 negative regulation of gene expression;GO:0048863 stem cell differentiation;GO:0045892 negative regulation of DNA-templated transcription;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3MIF2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XFX8-1", "uniprot_id": [ { "id": "ELL3_RAT", "url": "https://www.uniprot.org/uniprot/Q5XFX8", "type": "external" } ], "mass": 43803.0, "length": 387, "protein_name": "RNA polymerase II elongation factor ELL3", "gene_name": "Ell3", "organism": "Rat", "refseq_name": "RNA polymerase II elongation factor ELL3 isoform 1", "refseq_ac": [ { "id": "NP_001011957", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011957", "type": "external" } ], "gene_names_uniprotkb": "Ell3", "gene_names_refseq": "Ell3", "protein_names_uniprotkb": "RNA polymerase II elongation factor ELL3", "protein_names_refseq": "RNA polymerase II elongation factor ELL3 isoform 1; RNA polymerase II elongation factor ELL3; elongation factor RNA polymerase II-like 3", "tax_id": 10116, "disease": "", "pathway": " (rno:296102); (R-RNO-6807505)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Enhancer-binding elongation factor that specifically binds enhancers in embryonic stem cells (ES cells), marks them, and is required for their future activation during stem cell specification. Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Does not only bind to enhancer regions of active genes, but also marks the enhancers that are in a poised or inactive state in ES cells and is required for establishing proper RNA polymerase II occupancy at developmentally regulated genes in a cohesin-dependent manner. Probably required for priming developmentally regulated genes for later recruitment of the super elongation complex (SEC), for transcriptional activation during differentiation. Required for recruitment of P-TEFb within SEC during differentiation. Probably preloaded on germ cell chromatin, suggesting that it may prime gene activation by marking enhancers as early as in the germ cells. Promoting epithelial-mesenchymal transition (EMT) (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000987 cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0008023 transcription elongation factor complex", "go_biological_process": "GO:0010717 regulation of epithelial to mesenchymal transition;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0048863 stem cell differentiation;GO:0006366 transcription by RNA polymerase II;GO:2000179 positive regulation of neural precursor cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XFX8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q00566-1", "uniprot_id": [ { "id": "MECP2_RAT", "url": "https://www.uniprot.org/uniprot/Q00566", "type": "external" } ], "mass": 53047.0, "length": 492, "protein_name": "Methyl-CpG-binding protein 2", "gene_name": "Mecp2", "organism": "Rat", "refseq_name": "methyl-CpG-binding protein 2 isoform 2", "refseq_ac": [ { "id": "NP_073164", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073164", "type": "external" } ], "gene_names_uniprotkb": "Mecp2", "gene_names_refseq": "MECP2_e1; Mecp2", "protein_names_uniprotkb": "Methyl-CpG-binding protein 2; MeCp-2 protein; MeCp2", "protein_names_refseq": "meCP-2 protein; methyl-CpG-binding protein 2 isoform 2", "tax_id": 10116, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); syndromic X-linked intellectual disability Lubs type (Disease Ontology:DOID:0060799); X-linked intellectual disability-psychosis-macroorchidism syndrome (Disease Ontology:DOID:0060827); severe congenital encephalopathy due to MECP2 mutation (Disease Ontology:DOID:0111932); Rett syndrome (Disease Ontology:DOID:1206); autistic disorder (Disease Ontology:DOID:12849); transient cerebral ischemia (Disease Ontology:DOID:224); hepatocellular carcinoma (Disease Ontology:DOID:684); gastrointestinal system disease (Disease Ontology:DOID:77)", "pathway": " (rno:29386)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "1606614;16670375;17046689;17296936;19692427;20657584;21704097;22673903;26842955;27493805;29155278;29738885;34502162;34773221;35166074;35410641;35985556;36147353;37961023;38929606", "class_list": "", "function": "Aberrant brain functional and structural developments in MECP2 duplication rats., [RefSeq, PubMed]; Autistic-like social deficits in hippocampal MeCP2 knockdown rat models are rescued by ketamine., [RefSeq, PubMed]; CBP Expression Contributes to Neuropathic Pain via CREB and MeCP2 Regulation in the Spared Nerve Injury Rat Model. Publication Status: Online-Only, [RefSeq, PubMed]; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Inhibition of miR-205 promotes proliferation, migration and fibrosis of tenocytes through targeting MECP2: Implications for rotator cuff injury., [RefSeq, PubMed]; MiR-488-3p facilitates wound healing through CYP1B1-mediated Wnt/beta-catenin signaling pathway by targeting MeCP2., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 10, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 10, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 10, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q09HV7;Q09HV8", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003729 mRNA binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0001976 nervous system process involved in regulation of systemic arterial blood pressure;GO:1903861 positive regulation of dendrite extension;GO:0006020 inositol metabolic process;GO:0001964 startle response;GO:0097305 response to alcohol", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "Q00566-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RKH3-1", "uniprot_id": [ { "id": "K1143_RAT", "url": "https://www.uniprot.org/uniprot/Q5RKH3", "type": "external" } ], "mass": 17453.0, "length": 155, "protein_name": "Uncharacterized protein KIAA1143 homolog", "gene_name": "RGD1311745", "organism": "Rat", "refseq_name": "uncharacterized protein KIAA1143 homolog", "refseq_ac": [ { "id": "NP_001008330", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008330", "type": "external" } ], "gene_names_uniprotkb": "RGD1311745", "gene_names_refseq": "RGD1311745", "protein_names_uniprotkb": "Uncharacterized protein KIAA1143 homolog", "protein_names_refseq": "uncharacterized protein KIAA1143 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:301079)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0045171 intercellular bridge", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5RKH3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PQN4-1", "uniprot_id": [ { "id": "SAXO6_RAT", "url": "https://www.uniprot.org/uniprot/Q5PQN4", "type": "external" } ], "mass": 80698.0, "length": 719, "protein_name": "Stabilizer of axonemal microtubules 6", "gene_name": "Mdm1; Saxo6", "organism": "Rat", "refseq_name": "nuclear protein MDM1", "refseq_ac": [ { "id": "NP_001017459", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017459", "type": "external" } ], "gene_names_uniprotkb": "Mdm1; Saxo6; Mdm1", "gene_names_refseq": "Mdm1; Saxo6", "protein_names_uniprotkb": "Stabilizer of axonemal microtubules 6; Nuclear protein MDM1", "protein_names_refseq": "Mdm1 nuclear protein homolog; nuclear protein MDM1; transformed mouse 3T3 cell double minute 1", "tax_id": 10116, "disease": "retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (rno:314859)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0005874 microtubule;GO:0005814 centriole;GO:0097730 non-motile cilium", "go_biological_process": "GO:0060041 retina development in camera-type eye;GO:0046600 negative regulation of centriole replication", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5PQN4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54874-1", "uniprot_id": [ { "id": "MRCKA_RAT", "url": "https://www.uniprot.org/uniprot/O54874", "type": "external" } ], "mass": 197064.0, "length": 1732, "protein_name": "Serine/threonine-protein kinase MRCK alpha", "gene_name": "Cdc42bpa", "organism": "Rat", "refseq_name": "serine/threonine-protein kinase MRCK alpha", "refseq_ac": [ { "id": "NP_446109", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446109", "type": "external" } ], "gene_names_uniprotkb": "Cdc42bpa; Pk428", "gene_names_refseq": "Cdc42bpa; Mrck; Pk428", "protein_names_uniprotkb": "Serine/threonine-protein kinase MRCK alpha; 2.7.11.1; CDC42-binding protein kinase alpha; MRCK alpha; Myotonic dystrophy kinase-related CDC42-binding kinase alpha; Myotonic dystrophy protein kinase-like alpha", "protein_names_refseq": "MRCK alpha; Ser-Thr protein kinase related to the myotonic dystrophy protein kinase; myotonic dystrophy kinase-related CDC42-binding kinase alpha; myotonic dystrophy protein kinase-like alpha; mytonic dystrophy kinase-related Cdc42-binding kinase; serine/threonine-protein kinase MRCK alpha", "tax_id": 10116, "disease": "cerebral cavernous malformation (Disease Ontology:DOID:0060669); azoospermia (Disease Ontology:DOID:14227)", "pathway": " (rno:114116); (R-RNO-9013149); (R-RNO-9013406)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "11283256;12568720;16641100;18854160;21457715;22673903;25107909;9418861", "class_list": "", "function": "Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration (PubMed:9418861). Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12A and MYL9/MLC2 (PubMed:21457715). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates: PPP1R12C, LIMK1 and LIMK2. May play a role in TFRC-mediated iron uptake. In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). Triggers the formation of an extrusion apical actin ring required for epithelial extrusion of apoptotic cells (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, PubMed]; Study reports that MRCK and myosin II-related MYO18A linked by the adaptor protein LRAP35a form a functional tripartite complex, which is responsible for the assembly of lamellar actomyosin bundles and of a subnuclear actomyosin network., [RefSeq, PubMed]; The functional relevance of the LRAP25-MRCK complex in LIMK1-cofilin signaling and the importance of LRAP adaptors as key determinants of MRCK cellular localization and downstream specificities., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "1.16.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.1.-", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "1.6.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.-", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005911 cell-cell junction;GO:0030027 lamellipodium;GO:0031252 cell leading edge", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0016477 cell migration;GO:0051056 regulation of small GTPase mediated signal transduction;GO:0030036 actin cytoskeleton organization;GO:0007010 cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O54874-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P25030-1", "uniprot_id": [ { "id": "K1C20_RAT", "url": "https://www.uniprot.org/uniprot/P25030", "type": "external" } ], "mass": 49388.0, "length": 429, "protein_name": "Keratin, type I cytoskeletal 20", "gene_name": "Krt20", "organism": "Rat", "refseq_name": "keratin, type I cytoskeletal 20", "refseq_ac": [ { "id": "NP_775151", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775151", "type": "external" } ], "gene_names_uniprotkb": "Krt20; Krt21", "gene_names_refseq": "Krt20; Krt21", "protein_names_uniprotkb": "Keratin, type I cytoskeletal 20; CK-20; CK-21; Cytokeratin-20; Cytokeratin-21; K20; Keratin-20", "protein_names_refseq": "CK-20; CK-21; K20; cytokeratin-20; cytokeratin-21; keratin 20, type I; keratin, type I cytoskeletal 20", "tax_id": 10116, "disease": "colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:286912); (R-RNO-6805567); (R-RNO-6809371)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "1711044;22673903;7689500", "class_list": "", "function": "Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030280 structural constituent of skin epidermis;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0045095 keratin filament;GO:0005882 intermediate filament", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0006915 apoptotic process;GO:0050708 regulation of protein secretion;GO:0009267 cellular response to starvation;GO:0045109 intermediate filament organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P25030-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TT49-1", "uniprot_id": [ { "id": "MRCKB_RAT", "url": "https://www.uniprot.org/uniprot/Q7TT49", "type": "external" } ], "mass": 194888.0, "length": 1713, "protein_name": "Serine/threonine-protein kinase MRCK beta", "gene_name": "Cdc42bpb", "organism": "Rat", "refseq_name": "serine/threonine-protein kinase MRCK beta", "refseq_ac": [ { "id": "NP_446072", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446072", "type": "external" } ], "gene_names_uniprotkb": "Cdc42bpb", "gene_names_refseq": "Cdc42bpb", "protein_names_uniprotkb": "Serine/threonine-protein kinase MRCK beta; 2.7.11.1; CDC42-binding protein kinase beta; DMPK-like beta; MRCK beta; Myotonic dystrophy kinase-related CDC42-binding kinase beta; Myotonic dystrophy protein kinase-like beta", "protein_names_refseq": "CDC42 binding protein kinase beta (DMPK-like); Cdc42-binding protein kinase beta; DMPK-like beta; MRCK beta; myotonic dystrophy kinase-related CDC42-binding kinase beta; myotonic dystrophy protein kinase-like beta; serine/threonine-protein kinase MRCK beta", "tax_id": 10116, "disease": "cerebral cavernous malformation (Disease Ontology:DOID:0060669); azoospermia (Disease Ontology:DOID:14227)", "pathway": " (rno:113960); (R-RNO-9013406)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "18854160;21240187;21457715;22673903;25107909;9418861", "class_list": "", "function": "Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21240187, PubMed:21457715). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A (PubMed:18854160). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Study reports that MRCK and myosin II-related MYO18A linked by the adaptor protein LRAP35a form a functional tripartite complex, which is responsible for the assembly of lamellar actomyosin bundles and of a subnuclear actomyosin network., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O54875", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "1.16.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.1.-", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0030027 lamellipodium", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0016477 cell migration;GO:0030036 actin cytoskeleton organization;GO:0031032 actomyosin structure organization;GO:0007010 cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q7TT49-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C5W1-1", "uniprot_id": [ { "id": "MAP1S_RAT", "url": "https://www.uniprot.org/uniprot/P0C5W1", "type": "external" } ], "mass": 102806.0, "length": 972, "protein_name": "Microtubule-associated protein 1S", "gene_name": "Map1s", "organism": "Rat", "refseq_name": "microtubule-associated protein 1S", "refseq_ac": [ { "id": "NP_001099540", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099540", "type": "external" } ], "gene_names_uniprotkb": "Map1s", "gene_names_refseq": "Bpy2ip1; Map1s; Mtap1s", "protein_names_uniprotkb": "Microtubule-associated protein 1S; MAP-1S", "protein_names_refseq": "BPY2 interacting protein 1; MAP-1S; microtubule-associated protein 1S", "tax_id": 10116, "disease": "", "pathway": " (rno:290640)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17658481;22673903;29393594;38843836", "class_list": "", "function": "Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003779 actin binding;GO:0008017 microtubule binding;GO:0042802 identical protein binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005813 centrosome;GO:0005819 spindle", "go_biological_process": "GO:0051310 metaphase chromosome alignment;GO:0007399 nervous system development;GO:0007409 axonogenesis;GO:0016358 dendrite development;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P0C5W1-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RYL1-1", "uniprot_id": [ { "id": "DERPC_RAT", "url": "https://www.uniprot.org/uniprot/B2RYL1", "type": "external" } ], "mass": 52095.0, "length": 533, "protein_name": "Decreased expression in renal and prostate cancer protein", "gene_name": "Derpc", "organism": "Rat", "refseq_name": "decreased expression in renal and prostate cancer protein", "refseq_ac": [ { "id": "NP_001365309", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001365309", "type": "external" } ], "gene_names_uniprotkb": "Derpc", "gene_names_refseq": "Derpc", "protein_names_uniprotkb": "Decreased expression in renal and prostate cancer protein", "protein_names_refseq": "decreased expression in renal and prostate cancer protein", "tax_id": 10116, "disease": "", "pathway": " (rno:116621582)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Potential tumor suppressor., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B2RYL1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZBP4-1", "uniprot_id": [ { "id": "MICA1_RAT", "url": "https://www.uniprot.org/uniprot/D3ZBP4", "type": "external" } ], "mass": 116672.0, "length": 1047, "protein_name": "[F-actin]-monooxygenase MICAL1", "gene_name": "Mical1", "organism": "Rat", "refseq_name": "[F-actin]-monooxygenase MICAL1", "refseq_ac": [ { "id": "NP_001099867", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099867", "type": "external" } ], "gene_names_uniprotkb": "Mical1", "gene_names_refseq": "MICAL-1; Mical1; Nical", "protein_names_uniprotkb": "[F-actin]-monooxygenase MICAL1; 1.14.13.225; 1.6.3.1; MICAL-1; Molecule interacting with CasL protein 1", "protein_names_refseq": "F-actin-monooxygenase MICAL1; NEDD9 interacting protein with calponin homology and LIM domains; [F-actin]-methionine sulfoxide oxidase MICAL1; [F-actin]-monooxygenase MICAL1; microtubule associated monoxygenase, calponin and LIM domain containing 1; molecule interacting with CasL protein 1; protein-methionine sulfoxide oxidase MICAL1", "tax_id": 10116, "disease": "", "pathway": " (rno:294520)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15694364;16230022;22673903;29393594", "class_list": "", "function": "Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation of lamina-specific connectivity in the nervous system such as the development of lamina-restricted hippocampal connections. Through redox regulation of the actin cytoskeleton controls the intracellular distribution of secretory vesicles containing L1/neurofascin/NgCAM family proteins in neurons, thereby regulating their cell surface levels. May act as Rab effector protein and play a role in vesicle trafficking. Promotes endosomal tubule extension by associating with RAB8 (RAB8A or RAB8B), RAB10 and GRAF (GRAF1/ARHGAP26 or GRAF2/ARHGAP10) on the endosomal membrane which may connect GRAFs to Rabs, thereby participating in neosynthesized Rab8-Rab10-Rab11-dependent protein export (By similarity)., [UniProtKB, UniProtKB]; Tesults implicate MICALs in neuronal regeneration and support the possibility to attenuate axon repulsion in the injured spinal cord., [RefSeq, PubMed]; Using the microtubule depolymerizing drug nocodazole we detected a link between MICAL-1 and -3, and the microtubule cytoskeleton., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3ZJD1", "ec_number_list": [ { "id": "1.14.13.225", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.225", "type": "external" }, { "id": "1.6.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.1", "type": "external" }, { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "1.6.99.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.99.1", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.14.13.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.8", "type": "external" } ], "go_molecular_function": "GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen;GO:0003779 actin binding;GO:0017124 SH3 domain binding;GO:0019901 protein kinase binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0045171 intercellular bridge", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0030036 actin cytoskeleton organization;GO:1903305 regulation of regulated secretory pathway;GO:0019417 sulfur oxidation;GO:0030042 actin filament depolymerization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "D3ZBP4-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62812-1", "uniprot_id": [ { "id": "MYH9_RAT", "url": "https://www.uniprot.org/uniprot/Q62812", "type": "external" } ], "mass": 226338.0, "length": 1961, "protein_name": "Myosin-9", "gene_name": "Myh9", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Myh9", "gene_names_refseq": "", "protein_names_uniprotkb": "Myosin-9; Cellular myosin heavy chain, type A; Myosin heavy chain 9; Myosin heavy chain, non-muscle IIa; NMMHC II-a; NMMHC-A; NMMHC-IIA; Non-muscle myosin heavy chain A; Non-muscle myosin heavy chain IIa", "protein_names_refseq": "", "tax_id": 10116, "disease": "orofacial cleft (Disease Ontology:DOID:0050567); metabolic acidosis (Disease Ontology:DOID:0050758); MYH-9 related disease (Disease Ontology:DOID:0060651); Alport syndrome 3A (Disease Ontology:DOID:0110032); autosomal dominant nonsyndromic deafness 17 (Disease Ontology:DOID:0110548); sensorineural hearing loss (Disease Ontology:DOID:10003); thrombocytopenia (Disease Ontology:DOID:1588); kidney disease (Disease Ontology:DOID:557); proteinuria (Disease Ontology:DOID:576); end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (R-RNO-2029482)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12944413;15505042;21933451;22673903;31201245;34502162;8740433", "class_list": "", "function": "Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping (By similarity). Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (By similarity). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005178 integrin binding;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005819 spindle", "go_biological_process": "GO:0001778 plasma membrane repair;GO:1903923 positive regulation of protein processing in phagocytic vesicle;GO:0060327 cytoplasmic actin-based contraction involved in cell motility;GO:0032962 positive regulation of inositol trisphosphate biosynthetic process;GO:0001525 angiogenesis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q62812-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20689-1", "uniprot_id": [ { "id": "MYLK2_RAT", "url": "https://www.uniprot.org/uniprot/P20689", "type": "external" } ], "mass": 65816.0, "length": 610, "protein_name": "Myosin light chain kinase 2, skeletal/cardiac muscle", "gene_name": "Mylk2", "organism": "Rat", "refseq_name": "myosin light chain kinase 2, skeletal/cardiac muscle", "refseq_ac": [ { "id": "NP_476557", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476557", "type": "external" } ], "gene_names_uniprotkb": "Mylk2", "gene_names_refseq": "Klmc; Mlck; Mylk2", "protein_names_uniprotkb": "Myosin light chain kinase 2, skeletal/cardiac muscle; 2.7.11.18; MLCK2", "protein_names_refseq": "MLCK2; myosin light chain kinase 2, skeletal muscle; myosin light chain kinase 2, skeletal/cardiac muscle; myosin, light polypeptide kinase 2", "tax_id": 10116, "disease": "hypertrophic cardiomyopathy 1 (Disease Ontology:DOID:0110307)", "pathway": " (rno:117558)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12105199;12748068;18621396;21209319;22100921;22673903;2465691;2839493;30680929", "class_list": "", "function": "Ca(2+)/calmodulin-dependent kinase that phosphorylates the regulatory light chain (RLC) of sarcomeric myosin in skeletal and cardiac muscle. Phosphorylation of RLC promotes displacement of myosin cross-bridges from the thick filament backbone toward actin-containing thin filaments, increasing the probability of cross-bridge entry into force-generating states and thereby potentiating contractile force at submaximal Ca(2+) concentrations., [UniProtKB, UniProtKB, UniProtKB]; Down-regulation of miR-200c attenuates AngII-induced cardiac hypertrophy via targeting the MLCK-mediated pathway. Erratum:[J Cell Mol Med. 2023 Jul;27(14):2093-2094. doi: 10.1111/jcmm.17724. PMID: 37395337], [RefSeq, PubMed]; Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain., [UniProtKB, UniProtKB]; In rat skeletal muscles an increase of MLC2 phosphorylation is associated with the slow-to-fast transition regardless of whether hypertrophy or atrophy develops., [RefSeq, PubMed]; MLCK regulates Schwann cell cytoskeletal organization, cell differentiation and myelination., [RefSeq, PubMed]; PKC and MLCK pathways important in coronary endothelial dysfunction elicited by ischemia/reperfusion injury and cytokine release, [RefSeq, PubMed]; Rho-kinase and MLC kinase play a role in migratory defect in FAK null cells., [RefSeq, PubMed]; Src and MLCK form a swelling-induced protein complex that regulates volume recovery through membrane turnover and compensatory endocytosis under osmotic stress., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.18", "type": "external" } ], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0032027 myosin light chain binding;GO:0004687 myosin light chain kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0014816 skeletal muscle satellite cell differentiation;GO:0006468 protein phosphorylation;GO:0006936 muscle contraction;GO:0007165 signal transduction;GO:0007274 neuromuscular synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P20689-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35217-1", "uniprot_id": [ { "id": "MINP1_RAT", "url": "https://www.uniprot.org/uniprot/O35217", "type": "external" } ], "mass": 54589.0, "length": 481, "protein_name": "Multiple inositol polyphosphate phosphatase 1", "gene_name": "Minpp1", "organism": "Rat", "refseq_name": "multiple inositol polyphosphate phosphatase 1 precursor", "refseq_ac": [ { "id": "NP_062136", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062136", "type": "external" } ], "gene_names_uniprotkb": "Minpp1; Minpp1-ps1", "gene_names_refseq": "Minpp1", "protein_names_uniprotkb": "Multiple inositol polyphosphate phosphatase 1; 2,3-BPG phosphatase; 2,3-bisphosphoglycerate 3-phosphatase; 3.1.3.62; 3.1.3.80; Inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase; Ins(1,3,4,5)P(4) 3-phosphatase", "protein_names_refseq": "2,3-BPG phosphatase; 2,3-bisphosphoglycerate 3-phosphatase; inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase; ins(1,3,4,5)P(4) 3-phosphatase; multiple inositol polyphosphate histidine phosphatase 1; multiple inositol polyphosphate phosphatase 1 precursor", "tax_id": 10116, "disease": "pontocerebellar hypoplasia type 16 (Disease Ontology:DOID:0112333); papillary thyroid carcinoma (Disease Ontology:DOID:3969)", "pathway": " (rno:29688); (R-RNO-1855231)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "1653239;8384201;9359836;9923613", "class_list": "", "function": "Multiple inositol polyphosphate phosphatase that hydrolyzes 1D-myo-inositol 1,3,4,5,6-pentakisphosphate (InsP5[2OH]) and 1D-myo-inositol hexakisphosphate (InsP6) to a range of less phosphorylated inositol phosphates. This regulates the availability of these various small molecule second messengers and metal chelators which control many aspects of cell physiology (PubMed:1653239, PubMed:9359836). Has a weak in vitro activity towards 1D-myo-inositol 1,4,5-trisphosphate which is unlikely to be physiologically relevant. By regulating intracellular inositol polyphosphates pools, which act as metal chelators, it may control the availability of intracellular calcium and iron, which are important for proper neuronal development and homeostasis. May have a dual substrate specificity, and function as a 2,3-bisphosphoglycerate 3-phosphatase hydrolyzing 2,3-bisphosphoglycerate to 2-phosphoglycerate. 2,3-bisphosphoglycerate (BPG) is formed as part of the Rapoport-Luebering glycolytic bypass and is a regulator of systemic oxygen homeostasis as the major allosteric effector of hemoglobin (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.62", "type": "external" }, { "id": "3.1.3.80", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.80", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" } ], "go_molecular_function": "GO:0003993 acid phosphatase activity;GO:0030351 inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity;GO:0034417 bisphosphoglycerate 3-phosphatase activity;GO:0052745 inositol phosphate phosphatase activity;GO:0016312 inositol bisphosphate phosphatase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005788 endoplasmic reticulum lumen;GO:0005886 plasma membrane", "go_biological_process": "GO:0048015 phosphatidylinositol-mediated signaling;GO:0030003 intracellular monoatomic cation homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O35217-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02564-1", "uniprot_id": [ { "id": "MYH7_RAT", "url": "https://www.uniprot.org/uniprot/P02564", "type": "external" } ], "mass": 223083.0, "length": 1935, "protein_name": "Myosin-7", "gene_name": "Myh7", "organism": "Rat", "refseq_name": "myosin-7", "refseq_ac": [ { "id": "NP_058936", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058936", "type": "external" } ], "gene_names_uniprotkb": "Myh7", "gene_names_refseq": "Bmyo; Myh7; Myhcb; myHC-beta; myHC-slow", "protein_names_uniprotkb": "Myosin-7; MyHC-beta; MyHC-slow; Myosin heavy chain 7; Myosin heavy chain slow isoform; Myosin heavy chain, cardiac muscle beta isoform", "protein_names_refseq": "beta myosin heavy chain; myosin heavy chain polypeptide 7 cardiac muscle fetal; myosin heavy chain, cardiac muscle, fetal; myosin heavy chain, polypeptide 7; myosin, heavy chain 7, cardiac muscle, beta; myosin, heavy polypeptide 7, cardiac muscle, beta; myosin-7", "tax_id": 10116, "disease": "distal arthrogryposis (Disease Ontology:DOID:0050646); cardiomyopathy (Disease Ontology:DOID:0050700); intrinsic cardiomyopathy (Disease Ontology:DOID:0060036); distal myopathy 1 (Disease Ontology:DOID:0070197); familial hypertrophic cardiomyopathy (Disease Ontology:DOID:0080326); congenital myopathy 6 (Disease Ontology:DOID:0080719); spondylocarpotarsal synostosis syndrome (Disease Ontology:DOID:0090116); hypertrophic cardiomyopathy 1 (Disease Ontology:DOID:0110307); dilated cardiomyopathy 1S (Disease Ontology:DOID:0110454); autosomal recessive hyaline body myopathy (Disease Ontology:DOID:0111268); autosomal dominant hyaline body myopathy (Disease Ontology:DOID:0111269); distal arthrogryposis type 1 (Disease Ontology:DOID:0111596); distal arthrogryposis type 2B3 (Disease Ontology:DOID:0111602); distal arthrogryposis type 2A (Disease Ontology:DOID:0111605); hypertension (Disease Ontology:DOID:10763); heart disease (Disease Ontology:DOID:114); distal myopathy (Disease Ontology:DOID:11720); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930); hypothyroidism (Disease Ontology:DOID:1459); congenital heart disease (Disease Ontology:DOID:1682); myotonia congenita (Disease Ontology:DOID:2106); inclusion body myositis (Disease Ontology:DOID:3429); restrictive cardiomyopathy (Disease Ontology:DOID:397); myopathy (Disease Ontology:DOID:423); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); hypoplastic left heart syndrome (Disease Ontology:DOID:9955)", "pathway": " (rno:29557)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "22673903;23110217;2614840;26150528;2798112;29753027;32987653;34502162;6241892;7045682", "class_list": "", "function": "JMJD3 may be a key epigenetic regulator of beta-MHC expression in cardiomyocytes and a potential therapeutic target for cardiac hypertrophy., [RefSeq, PubMed]; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle., [UniProtKB, PubMed, UniProtKB, UniProtKB]; T3 Critically Affects the Mhrt/Brg1 Axis to Regulate the Cardiac MHC Switch: Role of an Epigenetic Cross-Talk. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 28, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0051015 actin filament binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005859 muscle myosin complex;GO:0005737 cytoplasm;GO:0001725 stress fiber;GO:0030017 sarcomere;GO:0032982 myosin filament", "go_biological_process": "GO:0031449 regulation of slow-twitch skeletal muscle fiber contraction;GO:1904385 cellular response to angiotensin;GO:0003009 skeletal muscle contraction;GO:0006936 muscle contraction;GO:0030049 muscle filament sliding", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P02564-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JLT0-1", "uniprot_id": [ { "id": "MYH10_RAT", "url": "https://www.uniprot.org/uniprot/Q9JLT0", "type": "external" } ], "mass": 228965.0, "length": 1976, "protein_name": "Myosin-10", "gene_name": "Myh10", "organism": "Rat", "refseq_name": "myosin-10", "refseq_ac": [ { "id": "NP_113708", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113708", "type": "external" } ], "gene_names_uniprotkb": "Myh10", "gene_names_refseq": "MCH-B; Myh10; NMMHC-B; SMemb", "protein_names_uniprotkb": "Myosin-10; Cellular myosin heavy chain, type B; Myosin heavy chain 10; Myosin heavy chain, non-muscle IIb; NMMHC II-b; NMMHC-B; NMMHC-IIB; Non-muscle myosin heavy chain B; Non-muscle myosin heavy chain IIb", "protein_names_refseq": "MCH-B(B2); NMMHC II-b; NMMHC-IIB; cellular myosin heavy chain, type B; myosin heavy chain, non-muscle IIb; myosin heavy chain, nonmuscle type B; myosin, heavy chain 10, non-muscle; myosin, heavy polypeptide 10, non-muscle; myosin-10; non-muscle myosin heavy chain B; non-muscle myosin heavy chain IIb; nonmuscle myosin heavy chain IIB; nonmuscle myosin heavy chain-B", "tax_id": 10116, "disease": "MYH-9 related disease (Disease Ontology:DOID:0060651)", "pathway": " (rno:79433)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11027611;18683930;22673903;26239291;32654195", "class_list": "", "function": "Filamentous nestin and nonmuscle myosin IIB are associated with a migratory phenotype in neonatal rat cardiomyocytes., [RefSeq, PubMed]; Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9 (By similarity). Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Study suggests that NMIIB remains constitutively active in support of methamphetamine associations, continuing to drive actin polymerization, such that memories associated with methamphetamine can be selectively targeted without the need for retrieval days to weeks after learning, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0051015 actin filament binding;GO:0043531 ADP binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098871 postsynaptic actin cytoskeleton;GO:0005737 cytoplasm;GO:0005819 spindle;GO:0005829 cytosol", "go_biological_process": "GO:0001778 plasma membrane repair;GO:0021592 fourth ventricle development;GO:0001701 in utero embryonic development;GO:0007155 cell adhesion;GO:0007409 axonogenesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9JLT0-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16409-1", "uniprot_id": [ { "id": "MYL3_RAT", "url": "https://www.uniprot.org/uniprot/P16409", "type": "external" } ], "mass": 22156.0, "length": 200, "protein_name": "Myosin light chain 3", "gene_name": "Myl3", "organism": "Rat", "refseq_name": "myosin light chain 3", "refseq_ac": [ { "id": "NP_036738", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036738", "type": "external" } ], "gene_names_uniprotkb": "Myl3; Mlc1v", "gene_names_refseq": "MLClV; Myl3; Mylc1v; rVMLC1", "protein_names_uniprotkb": "Myosin light chain 3; MLC1SB; MLClV; Myosin alkali light chain 1, ventricular; Myosin light chain 1, slow-twitch muscle B/ventricular isoform; Ventricular myosin light chain 1; rVMLC1", "protein_names_refseq": "MLC1SB; Myosin light chain 3, alkali, cardiac ventricles; myosin alkali light chain 1, ventricular; myosin light chain 3; myosin, light chain 3, alkali; myosin, light polypeptide 3; ventricular myosin light chain 1; ventricular, skeletal, slow; ventricular/slow twitch myosin alkali light chain", "tax_id": 10116, "disease": "hypertrophic cardiomyopathy 8 (Disease Ontology:DOID:0110314); osteoarthritis (Disease Ontology:DOID:8398)", "pathway": " (rno:24585); (R-RNO-390522)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "17494635;18988896;22673903;26109417;2717409;2798124;34502162;35509154", "class_list": "", "function": "Ameliorating effect of rutin against diclofenac-induced cardiac injury in rats with underlying function of FABP3, MYL3, and ANP., [RefSeq, PubMed]; Regulatory light chain of myosin. Does not bind calcium., [UniProtKB]; Slowing of shortening velocity in type IIb fibers with hindlimb unloading involves a decrease in the relative amount of Myl3., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003785 actin monomer binding;GO:0005509 calcium ion binding;GO:0003774 cytoskeletal motor activity", "go_cellular_component": "GO:0031674 I band;GO:0031672 A band;GO:0016459 myosin complex;GO:0016460 myosin II complex", "go_biological_process": "GO:0006936 muscle contraction;GO:0060048 cardiac muscle contraction;GO:0002026 regulation of the force of heart contraction;GO:0006942 regulation of striated muscle contraction;GO:0007519 skeletal muscle tissue development", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P16409-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5HZA4-1", "uniprot_id": [ { "id": "LYSM1_RAT", "url": "https://www.uniprot.org/uniprot/Q5HZA4", "type": "external" } ], "mass": 24878.0, "length": 227, "protein_name": "LysM and putative peptidoglycan-binding domain-containing protein 1", "gene_name": "Lysmd1", "organism": "Rat", "refseq_name": "lysM and putative peptidoglycan-binding domain-containing protein 1", "refseq_ac": [ { "id": "NP_001019473", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019473", "type": "external" } ], "gene_names_uniprotkb": "Lysmd1", "gene_names_refseq": "Lysmd1", "protein_names_uniprotkb": "LysM and putative peptidoglycan-binding domain-containing protein 1", "protein_names_refseq": "LysM, putative peptidoglycan-binding, domain containing 1; lysM and putative peptidoglycan-binding domain-containing protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:499671)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16641100;22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q562B1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5HZA4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U3Z6-1", "uniprot_id": [ { "id": "DEUP1_RAT", "url": "https://www.uniprot.org/uniprot/Q5U3Z6", "type": "external" } ], "mass": 70105.0, "length": 601, "protein_name": "Deuterosome assembly protein 1", "gene_name": "Deup1", "organism": "Rat", "refseq_name": "deuterosome assembly protein 1", "refseq_ac": [ { "id": "NP_001014109", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014109", "type": "external" } ], "gene_names_uniprotkb": "Deup1; Ccdc67", "gene_names_refseq": "Ccdc67; Deup1; RGD1306632", "protein_names_uniprotkb": "Deuterosome assembly protein 1; Coiled-coil domain-containing protein 67", "protein_names_refseq": "coiled-coil domain containing 67; coiled-coil domain-containing protein 67; deuterosome assembly protein 1; deuterosome protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:315438)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells and can generate more than 100 centrioles. Probably sufficient for the specification and formation of the deuterosome inner core. Interacts with CEP152 and recruits PLK4 to activate centriole biogenesis (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005814 centriole;GO:0098536 deuterosome", "go_biological_process": "GO:1903251 multi-ciliated epithelial cell differentiation;GO:0030030 cell projection organization;GO:0007099 centriole replication;GO:0098535 de novo centriole assembly involved in multi-ciliated epithelial cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5U3Z6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CHM7-1", "uniprot_id": [ { "id": "HACL1_RAT", "url": "https://www.uniprot.org/uniprot/Q8CHM7", "type": "external" } ], "mass": 63616.0, "length": 581, "protein_name": "2-hydroxyacyl-CoA lyase 1", "gene_name": "Hacl1", "organism": "Rat", "refseq_name": "2-hydroxyacyl-CoA lyase 1", "refseq_ac": [ { "id": "NP_445945", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445945", "type": "external" } ], "gene_names_uniprotkb": "Hacl1; 2hpcl; Hpcl2; Phyh2", "gene_names_refseq": "Hacl1; Hpcl2; Phyh2", "protein_names_uniprotkb": "2-hydroxyacyl-CoA lyase 1; 2-HPCL; 2-hydroxyphytanoyl-CoA lyase; 4.1.2.63; Phytanoyl-CoA 2-hydroxylase 2", "protein_names_refseq": "2-HPCL; 2-hydroxyacyl-CoA lyase 1; 2-hydroxyphytanoyl-CoA lyase; 2-hydroxyphytanoyl-Coenzyme A lyase; phytanoyl-CoA 2-hydroxylase 2; phytanoyl-Coenzyme A 2-hydroxylase 2", "tax_id": 10116, "disease": "", "pathway": " (rno:85255); (R-RNO-389599); (R-RNO-9033241)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10468558;15644336;22673903", "class_list": "", "function": "2-hydroxyphytanoyl-CoA lyase has a role in the breakdown of long chain 2-hydroxyfatty acids, [RefSeq, PubMed]; Catalyzes a carbon-carbon cleavage reaction; cleaves a 2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde., [UniProtKB]; Peroxisomal 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner. Involved in the degradation of 3-methyl-branched fatty acids like phytanic acid (PubMed:10468558). Involved also in the shortening of 2-hydroxy long-chain fatty acids (By similarity). Plays a significant role in the biosynthesis of heptadecanal in the liver (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "1.2.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "1.4.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" }, { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "5.1.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "4.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.9", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0016829 lyase activity;GO:0030976 thiamine pyrophosphate binding", "go_cellular_component": "GO:0005777 peroxisome", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006631 fatty acid metabolic process;GO:0001561 fatty acid alpha-oxidation;GO:0006625 protein targeting to peroxisome;GO:0097089 methyl-branched fatty acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8CHM7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P68403-1", "uniprot_id": [ { "id": "KPCB_RAT", "url": "https://www.uniprot.org/uniprot/P68403", "type": "external" } ], "mass": 76751.0, "length": 671, "protein_name": "Protein kinase C beta type", "gene_name": "Prkcb", "organism": "Rat", "refseq_name": "protein kinase C beta type isoform 2", "refseq_ac": [ { "id": "NP_001165776", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165776", "type": "external" } ], "gene_names_uniprotkb": "Prkcb; Pkcb; Prkcb1", "gene_names_refseq": "Pkcb; Prkcb1; Prkcb", "protein_names_uniprotkb": "Protein kinase C beta type; 2.7.11.13; PKC-B; PKC-beta", "protein_names_refseq": "PKC-beta; protein kinase C beta II; protein kinase C beta I; protein kinase C beta type isoform 2; protein kinase C, beta 1", "tax_id": 10116, "disease": "silicosis (Disease Ontology:DOID:10325); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); dilated cardiomyopathy (Disease Ontology:DOID:12930); alcohol use disorder (Disease Ontology:DOID:1574); status epilepticus (Disease Ontology:DOID:1824); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hyperglycemia (Disease Ontology:DOID:4195); congestive heart failure (Disease Ontology:DOID:6000); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25023); (R-RNO-114516); (R-RNO-1169091); (R-RNO-416993); (R-RNO-4419969); (R-RNO-5099900); (R-RNO-5218921); (R-RNO-5668599); (R-RNO-76005)", "pathway_count": 9, "publication_count": 20, "publication_id_list": "10938109;11714718;18295358;19176525;21215369;22673903;2428667;32048876;32866516;3345563;3469647;35192161;36066426;3755379;3755404;7961692;8034726;8327493;8749392;9817842", "class_list": "", "function": "Acts as an activator of ferroptosis by mediating phosphorylation and activation of ACSL4. Also stimulates ferroptosis propagation by catalyzing phosphorylation of FOXK1., [UniProtKB, UniProtKB]; Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A. In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. Participates in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Phosphorylates SLC2A1/GLUT1, promoting glucose uptake by SLC2A1/GLUT1. Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis (By similarity). Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription. Phosphorylates KLHL3 in response to angiotensin II signaling, decreasing the interaction between KLHL3 and WNK4 (By similarity). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed, PubMed]; Intermittent Hypoxia Augments Pulmonary Vasoconstrictor Reactivity through PKCbeta/Mitochondrial Oxidant Signaling., [RefSeq, PubMed]; LncRNA HOTAIRM1 Involved in Nano NiO-Induced Pulmonary Fibrosis via Regulating PRKCB DNA Methylation-Mediated JNK/c-Jun Pathway., [RefSeq, PubMed]; Prenatal hypoxia attenuated contraction of offspring coronary artery associated with decreased PKCbeta Ser(660) phosphorylation and intracellular calcium., [RefSeq, PubMed]; The Mfn1-betaIIPKC Interaction Regulates Mitochondrial Dysfunction via Sirt3 Following Experimental Subarachnoid Hemorrhage. Erratum:[Transl Stroke Res. 2024 Aug;15(4):861-862. doi: 10.1007/s12975-024-01253-w. PMID: 38750251], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 20, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "P04410;P04411", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.1.91", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.91", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0044305 calyx of Held;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0042488 positive regulation of odontogenesis of dentin-containing tooth;GO:0010829 negative regulation of D-glucose transmembrane transport;GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P68403-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54256-1", "uniprot_id": [ { "id": "HAP1_RAT", "url": "https://www.uniprot.org/uniprot/P54256", "type": "external" } ], "mass": 70213.0, "length": 629, "protein_name": "Huntingtin-associated protein 1", "gene_name": "Hap1", "organism": "Rat", "refseq_name": "huntingtin-associated protein 1 isoform B", "refseq_ac": [ { "id": "NP_817091", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_817091", "type": "external" } ], "gene_names_uniprotkb": "Hap1", "gene_names_refseq": "HAP1-A; HAP1-B; Hap1", "protein_names_uniprotkb": "Huntingtin-associated protein 1; HAP-1", "protein_names_refseq": "HAP-1; huntingtin-associated protein 1 isoform B", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 68 (Disease Ontology:DOID:0112204); Huntington's disease (Disease Ontology:DOID:12858); melancholic depression (Disease Ontology:DOID:1595)", "pathway": " (rno:29430)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "10924259;12021262;12873381;12890790;15242649;16339760;16738245;16782802;17166838;19996106;20152113;21357693;22673903;22731248;23532844;26732589;27984179;33161374;35609730;7477378;9285789;9361024;9454836;9742138;9798945", "class_list": "", "function": "A key role for HAP1 protein was determined in the down-regulation Of GABA A receptor neurotransmission during cerebral ischemia., [RefSeq, PubMed]; HAP1 interacts with 14-3-3 to regulate epileptic seizure via GABAAR-mediated inhibitory synaptic transmission in pentylenetetrazole rat model., [RefSeq, PubMed]; Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that is homologous to the human huntingtin-associated protein 1. The human protein interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Two transcripts encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]., [RefSeq]; Immunohistochemical relationships of huntingtin-associated protein 1 with enteroendocrine cells in the pyloric mucosa of the rat stomach., [RefSeq, PubMed]; Originally identified as neuronal protein that specifically associates with HTT/huntingtin and the binding is enhanced by an expanded polyglutamine repeat within HTT possibly affecting HAP1 interaction properties. Both HTT and HAP1 are involved in intracellular trafficking and HAP1 is proposed to link HTT to motor proteins and/or transport cargos. Seems to play a role in vesicular transport within neurons and axons such as from early endosomes to late endocytic compartments and to promote neurite outgrowth. The vesicular transport function via association with microtubule-dependent transporters can be attenuated by association with mutant HTT. Involved in the axonal transport of BDNF and its activity-dependent secretion; the function seems to involve HTT, DCTN1 and a complex with SORT1. Involved in APP trafficking and seems to facilitate APP anterograde transport and membrane insertion thereby possibly reducing processing into amyloid beta. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptors to synapses; the function is dependent on kinesin motor protein KIF5 and is disrupted by HTT with expanded polyglutamine repeat. Involved in regulation of autophagosome motility by promoting efficient retrograde axonal transport. Seems to be involved in regulation of membrane receptor recycling and degradation, and respective signal transduction, including GABA(A) receptors, tyrosine kinase receptors, EGFR, IP3 receptor and androgen receptor. Among others suggested to be involved in control of feeding behavior (involving hypothalamic GABA(A) receptors), cerebellar and brainstem development (involving AHI1 and NTRK1/TrkA), postnatal neurogenesis (involving hypothalamic NTRK2/TrkB), and ITPR1/InsP3R1-mediated Ca(2+) release (involving HTT and possibly the effect of mutant HTT). Via association with DCTN1/dynactin p150-glued and HTT/huntingtin involved in cytoplasmic retention of REST in neurons. May be involved in ciliogenesis. Involved in regulation of exocytosis. Isoform A but not isoform B seems to be involved in formation of cytoplasmic inclusion bodies (STBs). In case of anomalous expression of TBP, can sequester a subset of TBP into STBs; sequestration is enhanced by an expanded polyglutamine repeat within TBP., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Study demonstrated that HAP1 is abundantly expressed in spinal neurons of the somatosensory, viscerosensory, and autonomic regions but absent in somatomotor neurons, suggesting that the spinal motoneurons are, due to lack of putative HAP1 protectivity, more vulnerable to stresses in neurodegenerative diseases than other HAP1-expressing neurons probably involved in spinal sensory and autonomic functions., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0044325 transmembrane transporter binding;GO:0017022 myosin binding", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005769 early endosome", "go_biological_process": "GO:0008090 retrograde axonal transport;GO:0010976 positive regulation of neuron projection development;GO:0015031 protein transport;GO:0031175 neuron projection development;GO:0006605 protein targeting", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P54256-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06486-1", "uniprot_id": [ { "id": "KC1D_RAT", "url": "https://www.uniprot.org/uniprot/Q06486", "type": "external" } ], "mass": 47316.0, "length": 415, "protein_name": "Casein kinase I isoform delta", "gene_name": "Csnk1d", "organism": "Rat", "refseq_name": "casein kinase I isoform delta isoform 1", "refseq_ac": [ { "id": "NP_620691", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620691", "type": "external" } ], "gene_names_uniprotkb": "Csnk1d; Hckid", "gene_names_refseq": "CKI-delta; Csnk1d", "protein_names_uniprotkb": "Casein kinase I isoform delta; 2.7.11.1; 2.7.11.26; CKI-delta; Tau-protein kinase CSNK1D", "protein_names_refseq": "casein kinase I isoform delta isoform 1; casein kinase I; tau-protein kinase CSNK1D", "tax_id": 10116, "disease": "syndromic X-linked intellectual disability Najm type (Disease Ontology:DOID:0060807); advanced sleep phase syndrome 2 (Disease Ontology:DOID:0110012); Alzheimer's disease (Disease Ontology:DOID:10652); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); colon cancer (Disease Ontology:DOID:219)", "pathway": " (rno:64462); (R-RNO-204005); (R-RNO-2565942); (R-RNO-380259); (R-RNO-380270); (R-RNO-380284); (R-RNO-380320); (R-RNO-5620912); (R-RNO-6791226); (R-RNO-8854518)", "pathway_count": 10, "publication_count": 9, "publication_id_list": "11165242;15961172;17594292;22673903;25245819;38843836;7665585;8454611;8648628", "class_list": "", "function": "Data show that casein kinases CSNK1D and CSNK1E inhibition resulted in rhythmic expression of clock genes in the liver, pancreas and suprachiasmatic nucleus., [RefSeq, PubMed]; Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. Phosphorylates NEDD9/HEF1 (By similarity). EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; This gene encodes a member of the casein kinase I (CKI) family of serine/threonine protein kinases. A highly similar human protein regulates an array of cellular processes by influencing the Wnt and hedgehog signaling pathways. The encoded protein may also be involved in the regulation of apoptosis, circadian rhythm, microtubule dynamics, chromosome segregation, and p53-mediated effects on growth. [provided by RefSeq, Feb 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99KK4", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0050321 tau-protein kinase activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005813 centrosome", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0006897 endocytosis;GO:0007165 signal transduction;GO:1990090 cellular response to nerve growth factor stimulus;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q06486-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3KR86-1", "uniprot_id": [ { "id": "MIC60_RAT", "url": "https://www.uniprot.org/uniprot/Q3KR86", "type": "external" } ], "mass": 67177.0, "length": 609, "protein_name": "MICOS complex subunit Mic60", "gene_name": "Immt", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Immt; Mic60", "gene_names_refseq": "", "protein_names_uniprotkb": "MICOS complex subunit Mic60; Mitochondrial inner membrane protein; Mitofilin", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:312444)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "18683930;22673903;26446791;27213235;34502162;38843836", "class_list": "", "function": "Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0061617 MICOS complex", "go_biological_process": "GO:0042407 cristae formation;GO:0051560 mitochondrial calcium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q3KR86-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63406-1", "uniprot_id": [ { "id": "MCF2L_RAT", "url": "https://www.uniprot.org/uniprot/Q63406", "type": "external" } ], "mass": 129410.0, "length": 1149, "protein_name": "Guanine nucleotide exchange factor DBS", "gene_name": "Mcf2l", "organism": "Rat", "refseq_name": "guanine nucleotide exchange factor DBS isoform X12", "refseq_ac": [ { "id": "XP_038950094", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_038950094", "type": "external" } ], "gene_names_uniprotkb": "Mcf2l; Ost", "gene_names_refseq": "Mcf2l; Ost; mcf 2l", "protein_names_uniprotkb": "Guanine nucleotide exchange factor DBS; DBL's big sister; MCF2-transforming sequence-like protein; OST oncogene", "protein_names_refseq": "guanine nucleotide exchange factor DBS isoform X12", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-193648); (R-RNO-416482); (R-RNO-8980692); (R-RNO-9013026); (R-RNO-9013106); (R-RNO-9013148); (R-RNO-9013149); (R-RNO-9013408)", "pathway_count": 8, "publication_count": 3, "publication_id_list": "16641100;22673903;7957046", "class_list": "", "function": "Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways. Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N-terminus., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0005545 1-phosphatidylinositol binding;GO:0035091 phosphatidylinositol binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0030027 lamellipodium;GO:0031234 extrinsic component of cytoplasmic side of plasma membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007266 Rho protein signal transduction;GO:0035025 positive regulation of Rho protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q63406-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CJH2-1", "uniprot_id": [ { "id": "DAB1_RAT", "url": "https://www.uniprot.org/uniprot/Q8CJH2", "type": "external" } ], "mass": 59900.0, "length": 555, "protein_name": "Disabled homolog 1", "gene_name": "Dab1", "organism": "Rat", "refseq_name": "disabled homolog 1", "refseq_ac": [ { "id": "NP_705885", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_705885", "type": "external" } ], "gene_names_uniprotkb": "Dab1", "gene_names_refseq": "Dab1", "protein_names_uniprotkb": "Disabled homolog 1", "protein_names_refseq": "DAB1, reelin adaptor protein; Dab, reelin signal transducer, homolog 1; disabled homolog 1", "tax_id": 10116, "disease": "spinocerebellar ataxia 37 (Disease Ontology:DOID:0050984); autistic disorder (Disease Ontology:DOID:12849); status epilepticus (Disease Ontology:DOID:1824)", "pathway": " (rno:266729); (R-RNO-8866376)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "11812785;16641100;28385118;28676854;29470947", "class_list": "", "function": "In intestine a truncated Dab1 variant transmits the reelin signal and may play a role in clathrin-mediated apical endocytosis and in the control of cell-to-cell junction assembly. Dab1 variant may be a nucleocytoplasmic shuttling protein, inferred from its sequence and nuclear location., [RefSeq, PubMed]; Melatonin ameliorated the neurotoxiciy and astrocyte activation induced by Abeta1-42 in the cerebral cortex. Melatonin also blocked the reduction in Reelin and Dab1 expression induced by Abeta1-42. Using in vitro study, Reelin inactivation completely abolished the protective effect of melatonin against Abeta1-42-induced neurotoxicity., [RefSeq, PubMed]; Signaling adapter of the reelin-mediated signaling pathway, which regulates the migration and differentiation of postmitotic neurons during brain development. Mediates intracellular transduction of Reelin signaling following reelin (RELN)-binding to its receptor: acts by docking proteins through its phosphotyrosine residues and PID domain., [UniProtKB, UniProtKB]; These results indicated that Dab1 mediated Ang II-induced podocyte apoptosis via p38 signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035591 signaling adaptor activity;GO:0043548 phosphatidylinositol 3-kinase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005903 brush border;GO:0043025 neuronal cell body;GO:0045177 apical part of cell", "go_biological_process": "GO:0021799 cerebral cortex radially oriented cell migration;GO:0007162 negative regulation of cell adhesion;GO:0016358 dendrite development;GO:0045666 positive regulation of neuron differentiation;GO:0001764 neuron migration", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8CJH2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q01062-1", "uniprot_id": [ { "id": "PDE2A_RAT", "url": "https://www.uniprot.org/uniprot/Q01062", "type": "external" } ], "mass": 104664.0, "length": 928, "protein_name": "cGMP-dependent 3',5'-cyclic phosphodiesterase", "gene_name": "Pde2a", "organism": "Rat", "refseq_name": "cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A3", "refseq_ac": [ { "id": "NP_001137319", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137319", "type": "external" } ], "gene_names_uniprotkb": "Pde2a", "gene_names_refseq": "CGS-PDE; Pde2a2; Pde2a; Pde2", "protein_names_uniprotkb": "cGMP-dependent 3',5'-cyclic phosphodiesterase; 3.1.4.17; CGS-PDE; Cyclic GMP-stimulated phosphodiesterase; cGSPDE", "protein_names_refseq": "cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A3; cGMP-dependent 3',5'-cyclic phosphodiesterase; cyclic GMP-stimulated phosphodiesterase; phosphodiesterase 2A, cGMP-stimulated", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700)", "pathway": " (rno:81743); (R-RNO-418457); (R-RNO-418555)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "1326532;21724846;22673903;25916722;26243800;28463107;29393594;31100470;37296663;7811274", "class_list": "", "function": "CRISPR/Cas9 Knock-Out in Primary Neonatal and Adult Cardiomyocytes Reveals Distinct cAMP Dynamics Regulation by Various PDE2A and PDE3A Isoforms. Publication Status: Online-Only, [RefSeq, PubMed]; Cardiac hypertrophy is inhibited by a local pool of cAMP regulated by PDE2A., [RefSeq, PubMed]; PDE2 regulates membrane potential, respiration and permeability transition of rodent subsarcolemmal cardiac mitochondria., [RefSeq, PubMed]; Pde2 overexpression decreased BNP stimulation of cGMP and BNP responses to the Ca current, intracellular Ca transient, and neurotransmitter release. Pde2 was higher in stellate neurons from prohypertensive rats vs normotensives., [RefSeq, PubMed]; Regulates mitochondrial cAMP levels and respiration (By similarity). Involved in the regulation of mitochondria morphology/dynamics and apoptotic cell death via local modulation of cAMP/PKA signaling in the mitochondrion, including the monitoring of local cAMP levels at the outer mitochondrial membrane and of PKA-dependent phosphorylation of Dnm1l (PubMed:28463107)., [UniProtKB, PubMed, UniProtKB]; Regulates mitochondrial cAMP levels and respiration. Involved in the regulation of mitochondria morphology/dynamics and apoptotic cell death via local modulation of cAMP/PKA signaling in the mitochondrion, including the monitoring of local cAMP levels at the outer mitochondrial membrane and of PKA-dependent phosphorylation of DNM1L., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Using pharmacological and genetic approaches combined with real-time FRET imaging and high resolution microscopy, we demonstrate that in rat cardiac myocytes and other cell types mitochondrial PDE2A2 regulates local cAMP levels and PKA-dependent phosphorylation of Drp1. Publication Status: Online-Only, [RefSeq, PubMed]; cGMP-activated cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher efficiency with cGMP compared to cAMP (By similarity). Plays a role in cell growth and migration (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.53", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.1.4.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.17", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.25", "type": "external" }, { "id": "3.6.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.14", "type": "external" }, { "id": "3.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1", "type": "external" }, { "id": "3.6.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9", "type": "external" } ], "go_molecular_function": "GO:0030911 TPR domain binding;GO:0042301 phosphate ion binding;GO:0000287 magnesium ion binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0097457 hippocampal mossy fiber;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0003170 heart valve development;GO:0061028 establishment of endothelial barrier;GO:1904880 response to hydrogen sulfide;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q01062-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C5E3-1", "uniprot_id": [ { "id": "PALLD_RAT", "url": "https://www.uniprot.org/uniprot/P0C5E3", "type": "external" } ], "mass": 66705.0, "length": 603, "protein_name": "Palladin", "gene_name": "LOC134478835; Palld", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "LOC134478835; Palld; LOC134478835; Palldl1", "gene_names_refseq": "", "protein_names_uniprotkb": "Palladin", "protein_names_refseq": "", "tax_id": 10116, "disease": "pancreatic cancer (Disease Ontology:DOID:1793); pancreatic ductal carcinoma (Disease Ontology:DOID:3587)", "pathway": "", "pathway_count": 0, "publication_count": 9, "publication_id_list": "10931874;11438925;11553711;12932445;16125169;16868024;22659164;22673903;23565266", "class_list": "", "function": "Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Plays a role in neurite outgrowth and in the establishment of polarity during neuronal morphogenesis. Participates in the acquisition of the reactive astrocyte morphology., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0008092 cytoskeletal protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005884 actin filament;GO:0005925 focal adhesion", "go_biological_process": "GO:0016477 cell migration;GO:0031175 neuron projection development;GO:0030036 actin cytoskeleton organization;GO:0071456 cellular response to hypoxia;GO:0003334 keratinocyte development", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P0C5E3-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O55232-1", "uniprot_id": [ { "id": "OREX_RAT", "url": "https://www.uniprot.org/uniprot/O55232", "type": "external" } ], "mass": 13645.0, "length": 130, "protein_name": "Hypocretin neuropeptide precursor", "gene_name": "Hcrt", "organism": "Rat", "refseq_name": "hypocretin neuropeptide precursor precursor", "refseq_ac": [ { "id": "NP_037311", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037311", "type": "external" } ], "gene_names_uniprotkb": "Hcrt; Ox; Ppox", "gene_names_refseq": "Hcrt; orexin-A", "protein_names_uniprotkb": "Hypocretin neuropeptide precursor; Hcrt1; Hcrt2; Hcrt; Hypocretin-1; Hypocretin-2; Hypocretin; Orexin precursor; Prepro-orexin; Preprohypocretin", "protein_names_refseq": "Hypocretin (orexin) neuropeptide; hypocretin neuropeptide precursor precursor; orexin; prepro-orexin; preprohypocretin", "tax_id": 10116, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); obstructive sleep apnea (Disease Ontology:DOID:0050848); withdrawal disorder (Disease Ontology:DOID:0060001); sleeping sickness (Disease Ontology:DOID:10112); Prader-Willi syndrome (Disease Ontology:DOID:11983); Guillain-Barre syndrome (Disease Ontology:DOID:12842); alcohol use disorder (Disease Ontology:DOID:1574); cannabis dependence (Disease Ontology:DOID:1849); hyperglycemia (Disease Ontology:DOID:4195); narcolepsy (Disease Ontology:DOID:8986); obesity (Disease Ontology:DOID:9970); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:25723); (R-RNO-389397); (R-RNO-416476)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "11283317;11340621;36656978;37344019;38338864;39056112;39119889;9419374;9491897;9879756", "class_list": "", "function": "A high-fat diet induced depression-like phenotype via hypocretin-HCRTR1 mediated inflammation activation. Publication Status: Online-Only, [RefSeq, PubMed]; Binds to orexin receptor HCRTR2/OX2R only (PubMed:9491897). Stimulates food intake (PubMed:9491897). Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner (PubMed:9879756)., [UniProtKB, PubMed, PubMed]; Binds to orexin receptor HCRTR2/OX2R only. Stimulates food intake. Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner., [UniProtKB, UniProtKB]; Binds to orexin receptors HCRTR1/OX1R and HCRTR2/OX2R with a high affinity (PubMed:9491897). Stimulates food intake (PubMed:9491897). Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner (PubMed:9879756)., [UniProtKB, PubMed, PubMed]; Binds to orexin receptors HCRTR1/OX1R and HCRTR2/OX2R with a high affinity. Stimulates food intake. Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner., [UniProtKB, UniProtKB]; Core body temperature varies according to the time of exercise without affecting orexin-A production in the dorsal hypothalamus in male rats., [RefSeq, PubMed]; Hypocretin-1/Hypocretin Receptor 1 Regulates Neuroplasticity and Cognitive Function through Hippocampal Lactate Homeostasis in Depressed Model., [RefSeq, PubMed]; Mutual Effects of Orexin and Bone Morphogenetic Proteins on Catecholamine Regulation Using Adrenomedullary Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions (PubMed:11283317, PubMed:11340621, PubMed:9491897). A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested (PubMed:9491897). A modulation effect on luteinizing hormone-releasing hormone (LHRH) secretion also suggests a more minor contribution to the regulation of reproductive function (PubMed:11340621, PubMed:9879756)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; The effect of orexin on the hypoxic ventilatory response of female rats is greatest in the active phase during diestrus., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005184 neuropeptide hormone activity;GO:0031771 type 1 orexin receptor binding;GO:0031772 type 2 orexin receptor binding;GO:0160041 neuropeptide activity", "go_cellular_component": "GO:0005791 rough endoplasmic reticulum;GO:0030141 secretory granule;GO:0048471 perinuclear region of cytoplasm;GO:0098794 postsynapse;GO:0099013 neuronal dense core vesicle lumen", "go_biological_process": "GO:0051970 negative regulation of transmission of nerve impulse;GO:0097305 response to alcohol;GO:0001659 temperature homeostasis;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007218 neuropeptide signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O55232-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88637-1", "uniprot_id": [ { "id": "PCY2_RAT", "url": "https://www.uniprot.org/uniprot/O88637", "type": "external" } ], "mass": 45220.0, "length": 404, "protein_name": "Ethanolamine-phosphate cytidylyltransferase", "gene_name": "Pcyt2", "organism": "Rat", "refseq_name": "ethanolamine-phosphate cytidylyltransferase", "refseq_ac": [ { "id": "NP_446020", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446020", "type": "external" } ], "gene_names_uniprotkb": "Pcyt2", "gene_names_refseq": "ET; Pcyt2", "protein_names_uniprotkb": "Ethanolamine-phosphate cytidylyltransferase; 2.7.7.14; CTP:phosphoethanolamine cytidylyltransferase; Phosphorylethanolamine transferase", "protein_names_refseq": "CTP:phopshoethanolamine cytidylyltransferase; CTP:phosphoethanolamine cytidylyltransferase; ethanolamine-phosphate cytidylyltransferase; phosphorylethanolamine transferase", "tax_id": 10116, "disease": "hereditary spastic paraplegia 82 (Disease Ontology:DOID:0112343)", "pathway": " (rno:89841); (R-RNO-1483213)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10493918;14759225;22673903", "class_list": "", "function": "Ethanolamine-phosphate cytidylyltransferase that catalyzes the second step in the synthesis of phosphatidylethanolamine (PE) from ethanolamine via the CDP-ethanolamine pathway. Phosphatidylethanolamine is a dominant inner-leaflet phospholipid in cell membranes, where it plays a role in membrane function by structurally stabilizing membrane-anchored proteins, and participates in important cellular processes such as cell division, cell fusion, blood coagulation, and apoptosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Supply of CDPethanolamine, via the expression level of ECT, is an important factor governing the rate of PtdEtn biosynthesis in mammalian cells, under the condition that the amount of DAG is not limiting, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6AZ30", "ec_number_list": [ { "id": "2.7.7.14", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.14", "type": "external" } ], "go_molecular_function": "GO:0004306 ethanolamine-phosphate cytidylyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006646 phosphatidylethanolamine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O88637-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10888-1", "uniprot_id": [ { "id": "COX41_RAT", "url": "https://www.uniprot.org/uniprot/P10888", "type": "external" } ], "mass": 19515.0, "length": 169, "protein_name": "Cytochrome c oxidase subunit 4 isoform 1, mitochondrial", "gene_name": "Cox4i1", "organism": "Rat", "refseq_name": "cytochrome c oxidase subunit 4 isoform 1, mitochondrial precursor", "refseq_ac": [ { "id": "NP_058898", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058898", "type": "external" } ], "gene_names_uniprotkb": "Cox4i1; Cox4a; Cox4", "gene_names_refseq": "Cox4a; Cox4i1; Cox4", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 4 isoform 1, mitochondrial; COX IV-1; Cytochrome c oxidase polypeptide IV; Cytochrome c oxidase subunit IV isoform 1", "protein_names_refseq": "COX IV-1; cytochrome c oxidase polypeptide IV; cytochrome c oxidase subunit 4 isoform 1, mitochondrial precursor; cytochrome c oxidase, subunit 4a; cytochrome c oxidase, subunit IVa", "tax_id": 10116, "disease": "mitochondrial complex IV deficiency nuclear type 16 (Disease Ontology:DOID:0070501); protein-energy malnutrition (Disease Ontology:DOID:11801)", "pathway": " (rno:29445); (R-RNO-5628897); (R-RNO-611105); (R-RNO-9707564)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "2159010;2165254;2174541;22673903;2541414;2544859;26446791;27213235;28161363;29393594;31511561;7601105", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The results provided in this communication indicate that a multi-protein ribonucleoprotein complex is formed in association with the COXIV 38 nt zipcode., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005829 cytosol;GO:0031966 mitochondrial membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0007584 response to nutrient;GO:0006123 mitochondrial electron transport, cytochrome c to oxygen", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P10888-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33535-1", "uniprot_id": [ { "id": "OPRM_RAT", "url": "https://www.uniprot.org/uniprot/P33535", "type": "external" } ], "mass": 44494.0, "length": 398, "protein_name": "Mu-type opioid receptor", "gene_name": "Oprm1", "organism": "Rat", "refseq_name": "mu-type opioid receptor isoform IA", "refseq_ac": [ { "id": "NP_001033686", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033686", "type": "external" } ], "gene_names_uniprotkb": "Oprm1; Ror-b", "gene_names_refseq": "MORA; Oprm1; Oprm; Oprrm1", "protein_names_uniprotkb": "Mu-type opioid receptor; M-OR-1; MOR-1; Opioid receptor B", "protein_names_refseq": "M-OR-1; MOR-1; MUOR1; mu-type opioid receptor isoform IA; mu-type opioid receptor; opioid receptor B", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); withdrawal disorder (Disease Ontology:DOID:0060001); autism spectrum disorder (Disease Ontology:DOID:0060041); opioid abuse (Disease Ontology:DOID:11206); sciatic neuropathy (Disease Ontology:DOID:11446); extrahepatic cholestasis (Disease Ontology:DOID:13619); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); drug psychosis (Disease Ontology:DOID:1742); post-traumatic stress disorder (Disease Ontology:DOID:2055); brain ischemia (Disease Ontology:DOID:2316); opiate dependence (Disease Ontology:DOID:2559); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); schizophrenia (Disease Ontology:DOID:5419); rheumatoid arthritis (Disease Ontology:DOID:7148); neonatal abstinence syndrome (Disease Ontology:DOID:9828); obesity (Disease Ontology:DOID:9970); drug dependence (Disease Ontology:DOID:9974); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:25601); (R-RNO-111885); (R-RNO-202040); (R-RNO-375276); (R-RNO-418594)", "pathway_count": 5, "publication_count": 44, "publication_id_list": "10488100;10744734;10820022;10842167;10908300;11060299;11278523;11580279;11695897;11896051;12356297;12519790;14645661;14729105;15525342;15857684;15944153;16682964;17005904;17384143;17548356;17947509;1846076;18558479;19324084;19959593;20592872;21292762;37482304;38140734;7532594;7595566;7678862;7733926;8051154;8189219;8234282;8240812;8393525;8394245;8624732;9224819;9572309;9877183", "class_list": "", "function": "Accumbal mu-opioid receptors and salt taste-elicited hedonic responses in a rodent model of prenatal adversity, and their correlates using human functional genomics., [RefSeq, PubMed]; N[6]-Methyladenosine methylase METTL3 contributes to neuropathic pain by epigenetic silencing of mu opioid receptor., [RefSeq, PubMed]; Receptor for endogenous opioids such as beta-endorphin and endomorphin (PubMed:11060299, PubMed:15944153, PubMed:16682964, PubMed:17384143, PubMed:17947509, PubMed:1846076, PubMed:18558479, PubMed:21292762, PubMed:7595566, PubMed:7678862, PubMed:8051154, PubMed:8240812, PubMed:8393525, PubMed:9224819, PubMed:9572309). Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone (PubMed:11060299, PubMed:15944153, PubMed:16682964, PubMed:17384143, PubMed:17947509, PubMed:1846076, PubMed:18558479, PubMed:21292762, PubMed:7595566, PubMed:7678862, PubMed:8051154, PubMed:8240812, PubMed:8393525, PubMed:9224819, PubMed:9572309). Also activated by enkephalin peptides, such as Met-enkephalin or Met-enkephalin-Arg-Phe, with higher affinity for Met-enkephalin-Arg-Phe (PubMed:8624732). Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G protein complex and subsequent exchange of GDP for GTP in the G protein alpha subunit leading to dissociation of the G protein complex with the free GTP-bound G protein alpha and the G protein beta-gamma dimer activating downstream cellular effectors (PubMed:16682964, PubMed:9224819). The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1 isoforms Alpha-1 and Alpha-2, and to a lesser extent to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15 (PubMed:9224819, PubMed:9572309). They mediate an array of downstream cellular responses, including inhibition of adenylate cyclase activity and both N-type and L-type calcium channels, activation of inward rectifying potassium channels, mitogen-activated protein kinase (MAPK), phospholipase C (PLC), phosphoinositide/protein kinase (PKC), phosphoinositide 3-kinase (PI3K) and regulation of NF-kappa-B (PubMed:15944153, PubMed:21292762, PubMed:7595566, PubMed:9572309). Also couples to adenylate cyclase stimulatory G alpha proteins (PubMed:7595566). The selective temporal coupling to G proteins and subsequent signaling can be regulated by RGSZ proteins, such as RGS9, RGS17 and RGS4. Phosphorylation by members of the GPRK subfamily of Ser/Thr protein kinases and association with beta-arrestins is involved in short-term receptor desensitization (PubMed:11060299, PubMed:17384143, PubMed:17947509, PubMed:18558479). Beta-arrestins associate with the GPRK-phosphorylated receptor and uncouple it from the G protein thus terminating signal transduction. The phosphorylated receptor is internalized through endocytosis via clathrin-coated pits which involves beta-arrestins. The activation of the ERK pathway occurs either in a G protein-dependent or a beta-arrestin-dependent manner and is regulated by agonist-specific receptor phosphorylation (PubMed:11278523, PubMed:11896051, PubMed:15944153). Acts as a class A G protein-coupled receptor (GPCR) which dissociates from beta-arrestin at or near the plasma membrane and undergoes rapid recycling. Receptor down-regulation pathways are varying with the agonist and occur dependent or independent of G protein coupling (PubMed:11060299, PubMed:17384143, PubMed:17947509, PubMed:18558479). Endogenous ligands induce rapid desensitization, endocytosis and recycling. Heterooligomerization with other GPCRs can modulate agonist binding, signaling and trafficking properties (PubMed:16682964, PubMed:17384143)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 1, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 27, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 22, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q2TV20;Q2TV21;Q4VWM5;Q4VWM7;Q4VWX7;Q4VWX8;Q62846;Q64064;Q64120", "ec_number_list": [], "go_molecular_function": "GO:0004985 G protein-coupled opioid receptor activity;GO:0031681 G-protein beta-subunit binding;GO:0004930 G protein-coupled receptor activity;GO:0019904 protein domain specific binding;GO:0001965 G-protein alpha-subunit binding", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005739 mitochondrion;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0005925 focal adhesion", "go_biological_process": "GO:0032100 positive regulation of appetite;GO:0006955 immune response;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007197 adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 4.6, "record_id": "P33535-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.1000100010001.111.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97608-1", "uniprot_id": [ { "id": "OPLA_RAT", "url": "https://www.uniprot.org/uniprot/P97608", "type": "external" } ], "mass": 137720.0, "length": 1288, "protein_name": "5-oxoprolinase", "gene_name": "Oplah", "organism": "Rat", "refseq_name": "5-oxoprolinase isoform 1", "refseq_ac": [ { "id": "NP_001426971", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001426971", "type": "external" } ], "gene_names_uniprotkb": "Oplah", "gene_names_refseq": "Oplah", "protein_names_uniprotkb": "5-oxoprolinase; 3.5.2.9; 5-OPase; 5-oxo-L-prolinase; Pyroglutamase", "protein_names_refseq": "5-OPase; 5-oxo-L-prolinase; 5-oxoprolinase isoform 1; pyroglutamase", "tax_id": 10116, "disease": "", "pathway": " (rno:116684); (R-RNO-174403)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "22673903;29393594;8943290", "class_list": "", "function": "Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5U3Z8", "ec_number_list": [ { "id": "3.5.2.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.9", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0017168 5-oxoprolinase (ATP-hydrolyzing) activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006749 glutathione metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P97608-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38552-1", "uniprot_id": [ { "id": "LEG4_RAT", "url": "https://www.uniprot.org/uniprot/P38552", "type": "external" } ], "mass": 36347.0, "length": 324, "protein_name": "Galectin-4", "gene_name": "Lgals4", "organism": "Rat", "refseq_name": "galectin-4", "refseq_ac": [ { "id": "NP_037107", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037107", "type": "external" } ], "gene_names_uniprotkb": "Lgals4", "gene_names_refseq": "L-36; L36LBI; Lgals4", "protein_names_uniprotkb": "Galectin-4; Gal-4; L-36 lactose-binding protein; L36LBP; Lactose-binding lectin 4", "protein_names_refseq": "L-36 lactose-binding protein; L36LBP; Lectin, galactose binding, soluble 4 (Galectin-4); gal-4; galectin-4; lactose-binding lectin 4; lectin, galactoside-binding, soluble, 4 (galectin 4)", "tax_id": 10116, "disease": "Miller-Dieker lissencephaly syndrome (Disease Ontology:DOID:0060469); diphthamide deficiency syndrome (Disease Ontology:DOID:0070476); diphthamide deficiency syndrome 1 (Disease Ontology:DOID:0070477)", "pathway": " (rno:25474)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15016449;22431161;22673903;22877695;23311731;27572741;7867792;8449956", "class_list": "", "function": "Data suggest a possible mechanism by which autophagy regulates trophoblast differentiation via regulation of galectin-4 (Gal-4) expression in order to establish the maternal-fetal interface. Publication Status: Online-Only, [RefSeq, PubMed]; Gal-4 sorts to axon plasma membrane segments by binding to sulfatide-containing microtubule-associated carriers and organizes the transport of L1, and likely other axonal glycoproteins, by attaching them to the carriers through their LacNAc termini., [RefSeq, PubMed]; Galectin that binds lactose and a related range of sugars., [UniProtKB]; In the rat placenta, immunohistochemical analysis showed that Gal4 is preferentially located in the maternal-fetal junctional zone. These results suggest that down-regulation of Gal4 may be involved in the promotion of trophoblast cell differentiation, [RefSeq, PubMed]; The expression of galectin 4 was determined in the rat small intestine during postnatal development., [RefSeq, PubMed]; This study demonistrated that neuronal galectin-4 as a candidate for a soluble regulator of OLG differentiation and, hence, myelination., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0016936 galactoside binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0042742 defense response to bacterium;GO:0002780 antibacterial peptide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P38552-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4FZU3-1", "uniprot_id": [ { "id": "NSRP1_RAT", "url": "https://www.uniprot.org/uniprot/Q4FZU3", "type": "external" } ], "mass": 64180.0, "length": 547, "protein_name": "Nuclear speckle splicing regulatory protein 1", "gene_name": "Nsrp1", "organism": "Rat", "refseq_name": "nuclear speckle splicing regulatory protein 1", "refseq_ac": [ { "id": "NP_001032266", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032266", "type": "external" } ], "gene_names_uniprotkb": "Nsrp1; Ccdc55; Nsrp70", "gene_names_refseq": "Ccdc55; NSrp70; Nsrp1; RGD1309863", "protein_names_uniprotkb": "Nuclear speckle splicing regulatory protein 1; Coiled-coil domain-containing protein 55; NSrp70; Nuclear speckle-related protein 70", "protein_names_refseq": "coiled-coil domain containing 55; coiled-coil domain-containing protein 55; nuclear speckle splicing regulatory protein 1; nuclear speckle-related protein 70", "tax_id": 10116, "disease": "", "pathway": " (rno:303346); (R-RNO-72163)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "RNA-binding protein that mediates pre-mRNA alternative splicing regulation (By similarity). Through CCDC118 regulation, may promote pre-adipocyte differentiation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Through CCDC118 regulation, may promote pre-adipocyte differentiation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:1904179 positive regulation of adipose tissue development;GO:0001701 in utero embryonic development;GO:0006397 mRNA processing;GO:0032502 developmental process;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4FZU3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47853-1", "uniprot_id": [ { "id": "PGS1_RAT", "url": "https://www.uniprot.org/uniprot/P47853", "type": "external" } ], "mass": 41706.0, "length": 369, "protein_name": "Biglycan", "gene_name": "Bgn", "organism": "Rat", "refseq_name": "biglycan precursor", "refseq_ac": [ { "id": "NP_058783", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058783", "type": "external" } ], "gene_names_uniprotkb": "Bgn", "gene_names_refseq": "BSPG1; Bgn", "protein_names_uniprotkb": "Biglycan; Bone/cartilage proteoglycan I; PG-S1", "protein_names_refseq": "PG-S1; Small proteoglycan I (biglycan), bone (BSPG1) (bone/cartilage proteclycan 1 precursor); biglycan precursor; bone/cartilage proteoglycan I", "tax_id": 10116, "disease": "X-linked Alport syndrome (Disease Ontology:DOID:0110034); Meester-Loeys syndrome (Disease Ontology:DOID:0111861); X-linked spondyloepimetaphyseal dysplasia (Disease Ontology:DOID:0112150); stomach cancer (Disease Ontology:DOID:10534); Alport syndrome (Disease Ontology:DOID:10983); dilated cardiomyopathy (Disease Ontology:DOID:12930); proteinuria (Disease Ontology:DOID:576)", "pathway": " (rno:25181); (R-RNO-1971475); (R-RNO-2022870); (R-RNO-2022923); (R-RNO-2024101)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "11728008;12719420;2081545;21454685;26479776", "class_list": "", "function": "Biglycan has a role in signaling; nitric oxide modulates the course of renal glomerular disease through regulation of biglycan expression, [RefSeq, PubMed]; Increased expression of biglycan mRNA in pressure-overloaded rat heart., [RefSeq, PubMed]; May be involved in collagen fiber assembly., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 2, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0050840 extracellular matrix binding;GO:0019955 cytokine binding;GO:0005539 glycosaminoglycan binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0031012 extracellular matrix;GO:0030133 transport vesicle;GO:0042383 sarcolemma", "go_biological_process": "GO:0001974 blood vessel remodeling;GO:0060348 bone development;GO:0061975 articular cartilage development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P47853-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q01129-1", "uniprot_id": [ { "id": "PGS2_RAT", "url": "https://www.uniprot.org/uniprot/Q01129", "type": "external" } ], "mass": 39805.0, "length": 354, "protein_name": "Decorin", "gene_name": "Dcn", "organism": "Rat", "refseq_name": "decorin precursor", "refseq_ac": [ { "id": "NP_077043", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077043", "type": "external" } ], "gene_names_uniprotkb": "Dcn", "gene_names_refseq": "Dcn", "protein_names_uniprotkb": "Decorin; Bone proteoglycan II; DSPG; Dermatan sulfate proteoglycan-II; PG-S2; PG40", "protein_names_refseq": "DSPG; PG-S2; PG40; bone proteoglycan II; decorin precursor; dermatan sulfate proteoglycan-II (decorin)", "tax_id": 10116, "disease": "congenital stromal corneal dystrophy (Disease Ontology:DOID:0060445); gestational diabetes (Disease Ontology:DOID:11714); Ehlers-Danlos syndrome (Disease Ontology:DOID:13359); asthma (Disease Ontology:DOID:2841); high grade glioma (Disease Ontology:DOID:3070); breast carcinoma (Disease Ontology:DOID:3459); myocardial infarction (Disease Ontology:DOID:5844); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:29139); (R-RNO-1474228); (R-RNO-1971475); (R-RNO-2022870); (R-RNO-2022923); (R-RNO-2024101); (R-RNO-3000178)", "pathway_count": 7, "publication_count": 7, "publication_id_list": "1390895;1493796;26479776;2764879;28290552;32731559;36917819", "class_list": "", "function": "Decorin Protects Cardiac Myocytes against Simulated Ischemia/Reperfusion Injury. Publication Status: Online-Only, [RefSeq, PubMed]; May affect the rate of fibrils formation (By similarity). May be implicated in the dilatation of the rat cervix., [UniProtKB]; May affect the rate of fibrils formation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Overexpression of decorin ameliorated diabetic cardiomyopathy and promoted angiogenesis through the IGF1R-AKT-VEGF signaling pathway in vivo and in vitro. Publication Status: Online-Only, [RefSeq, PubMed]; The myokine decorin improves the cardiac function in a rat model of isoprenaline-induced myocardial infarction., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005518 collagen binding;GO:0050840 extracellular matrix binding;GO:0005539 glycosaminoglycan binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005589 collagen type VI trimer", "go_biological_process": "GO:0032496 response to lipopolysaccharide;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0001822 kidney development;GO:0001890 placenta development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q01129-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04636-1", "uniprot_id": [ { "id": "MDHM_RAT", "url": "https://www.uniprot.org/uniprot/P04636", "type": "external" } ], "mass": 35684.0, "length": 338, "protein_name": "Malate dehydrogenase, mitochondrial", "gene_name": "Mdh2", "organism": "Rat", "refseq_name": "malate dehydrogenase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_112413", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112413", "type": "external" } ], "gene_names_uniprotkb": "Mdh2; Mor1", "gene_names_refseq": "Mdh2; Mor1", "protein_names_uniprotkb": "Malate dehydrogenase, mitochondrial; 1.1.1.37", "protein_names_refseq": "malate dehydrogenase 2, NAD (mitochondrial); malate dehydrogenase, mitochondrial precursor; malate dehydrogenase, mitochondrial", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 51 (Disease Ontology:DOID:0080433); brain ischemia (Disease Ontology:DOID:2316); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (rno:81829); (R-RNO-71403); (R-RNO-9837999); (R-RNO-9856872)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "14985449;19423663;22673903;23602810;24098488;26446791;27213235;34502162;3755817;3828294", "class_list": "", "function": "Mitochondrial malate dehydrogenase that catalyzes the reversible conversion of malate to oxaloacetate using NAD(+) as a cofactor. Plays a central role in the tricarboxylic acid (TCA) cycle contributing to cellular respiration and energy production via the mitochondrial electron transport chain (By similarity). Also participates in the malate-aspartate NADH shuttle, facilitating transfer of reducing equivalents between cytosol and mitochondria to maintain redox balance (NAD(+)/NADH homeostasis) and support metabolic flux between compartments (By similarity). In addition to its metabolic role, binds to RNA in cells, associating with cytosolic RNAs including tRNAs and mRNAs (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Our results indicate an alteration in the energy metabolism in hippocampus and striatum of infant rats after acute administration of l-tyrosine., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q6GSM4", "ec_number_list": [ { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "1.1.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.41", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0051087 protein-folding chaperone binding;GO:0030060 L-malate dehydrogenase (NAD+) activity;GO:0016615 malate dehydrogenase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0016020 membrane", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006094 gluconeogenesis;GO:0009060 aerobic respiration;GO:0006108 malate metabolic process;GO:0043490 malate-aspartate shuttle", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P04636-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4ABW7-1", "uniprot_id": [ { "id": "LYZL4_RAT", "url": "https://www.uniprot.org/uniprot/D4ABW7", "type": "external" } ], "mass": 16302.0, "length": 145, "protein_name": "Lysozyme-like protein 4", "gene_name": "Lyzl4", "organism": "Rat", "refseq_name": "lysozyme-like protein 4 precursor", "refseq_ac": [ { "id": "NP_001233112", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001233112", "type": "external" } ], "gene_names_uniprotkb": "Lyzl4; Lyza", "gene_names_refseq": "Lyza; Lyzl4; RGD1308401", "protein_names_uniprotkb": "Lysozyme-like protein 4; Lysozyme-4", "protein_names_refseq": "lysozyme a; lysozyme-4; lysozyme-like protein 4 precursor; lysozyme-like protein 4", "tax_id": 10116, "disease": "viral infectious disease (Disease Ontology:DOID:934)", "pathway": " (rno:363168)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22110709;26862561;27821286", "class_list": "", "function": "May be involved in fertilization (By similarity). Has no detectable bacteriolytic and lysozyme activities in vitro (PubMed:22110709)., [UniProtKB, PubMed, UniProtKB]; The characterization of Lyzl genes in the rat, [RefSeq, PubMed]; This study indicates a role for LYZL4 protein in sperm function, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003796 lysozyme activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0001669 acrosomal vesicle;GO:0036126 sperm flagellum", "go_biological_process": "GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization;GO:0009566 fertilization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D4ABW7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62918-1", "uniprot_id": [ { "id": "NELL2_RAT", "url": "https://www.uniprot.org/uniprot/Q62918", "type": "external" } ], "mass": 91334.0, "length": 819, "protein_name": "Protein kinase C-binding protein NELL2", "gene_name": "Nell2", "organism": "Rat", "refseq_name": "protein kinase C-binding protein NELL2 precursor", "refseq_ac": [ { "id": "NP_112332", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112332", "type": "external" } ], "gene_names_uniprotkb": "Nell2; Nel", "gene_names_refseq": "Nell2", "protein_names_uniprotkb": "Protein kinase C-binding protein NELL2; NEL-like protein 2", "protein_names_refseq": "NEL-like 2; NEL-like protein 2; protein kinase C-binding protein NELL2 precursor; protein kinase C-binding protein NELL2; rCG50753-like", "tax_id": 10116, "disease": "lung adenocarcinoma (Disease Ontology:DOID:3910)", "pathway": " (rno:81734)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10548494;10600492;12472893;12941464;17196548;18547942;19931511;25177948;25450684;28301916;32597395;35950455;38843836", "class_list": "", "function": "Acts as an endogenous inhibitor of PRKCB in glia., [UniProtKB, PubMed]; Data indicate that RNA interference of NEL-like protein 2 (NELL2) reduced NELL2 and gonadotropin-releasing hormone (GnRH) expression at multiple stages of sexual development. Publication Status: Online-Only, [RefSeq, PubMed]; Epididymal-secreted protein that signals through a ROS1-pathway to regulate the epididymal initial segment (IS) maturation, sperm maturation and male fertility., [UniProtKB, UniProtKB]; NELL2 Function in Axon Development of Hippocampal Neurons., [RefSeq, PubMed]; NELL2 may play an important role in the development of the CNS as well as maintenance of neural functions, by regulating the intracellular machinery involving Ca2+ signaling, synaptic transport and/or release of vesicles, [RefSeq, PubMed]; Plays multiple roles In neural tissues, regulates neuronal proliferation, survival, differentiation, polarization, as well as axon guidance and synaptic functions (PubMed:12941464, PubMed:18547942, PubMed:32597395). Plays an important role in axon development during neuronal differentiation through the MAPK intracellular signaling pathway (PubMed:32597395). Via binding to its receptor ROBO3, plays a role in axon guidance, functioning as a repulsive axon guidance cue that contributes to commissural axon guidance to the midline (By similarity). Required for neuron survival through the modulation of MAPK signaling pathways too (PubMed:12941464). Involved in the regulation of hypothalamic GNRH secretion and the control of puberty (PubMed:18547942)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Report shows that neural tissue-enriched multifunctional protein, NELL2 is a regulatory component of feeding behavior, possibly through a modulation of neuronal activity in the hypothalamus., [RefSeq, PubMed]; Transcriptional Regulatory Role of NELL2 in Preproenkephalin Gene Expression., [RefSeq, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 7, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "A1E5S7;C8CB44;Q561K2;Q8R417", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0042802 identical protein binding;GO:0005080 protein kinase C binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0030425 dendrite;GO:0043204 perikaryon", "go_biological_process": "GO:0046543 development of secondary female sexual characteristics;GO:0009566 fertilization;GO:0040008 regulation of growth;GO:0070050 neuron cellular homeostasis;GO:0022008 neurogenesis", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q62918-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54769-1", "uniprot_id": [ { "id": "FGF16_RAT", "url": "https://www.uniprot.org/uniprot/O54769", "type": "external" } ], "mass": 23753.0, "length": 207, "protein_name": "Fibroblast growth factor 16", "gene_name": "Fgf16", "organism": "Rat", "refseq_name": "fibroblast growth factor 16", "refseq_ac": [ { "id": "NP_068639", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068639", "type": "external" } ], "gene_names_uniprotkb": "Fgf16", "gene_names_refseq": "Fgf16", "protein_names_uniprotkb": "Fibroblast growth factor 16; FGF-16", "protein_names_refseq": "FGF-16; fibroblast growth factor 16", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 47 (Disease Ontology:DOID:0080425); syndactyly type 8 (Disease Ontology:DOID:0111813)", "pathway": " (rno:60464); (R-RNO-109704); (R-RNO-1257604); (R-RNO-190322); (R-RNO-190372); (R-RNO-190375); (R-RNO-5654221); (R-RNO-5654227); (R-RNO-5654228); (R-RNO-5654695); (R-RNO-5654699); (R-RNO-5654700); (R-RNO-5654704); (R-RNO-5654706); (R-RNO-5654710); (R-RNO-5654712); (R-RNO-5654719); (R-RNO-5654720); (R-RNO-5654727); (R-RNO-5654732); (R-RNO-5654733); (R-RNO-5673001); (R-RNO-6811558)", "pathway_count": 23, "publication_count": 4, "publication_id_list": "12851399;18337564;30230915;9473496", "class_list": "", "function": "Cardiac Fgf-16 expression supports cardiomyocyte survival and increases resistance to doxorubicin cytotoxicity., [RefSeq, PubMed]; Expression and release of FGF-16 in the neonatal myocardium interfere with cardiac myocyte proliferative potential by altering the local signaling environment via modulation of PKC activation and cell cycle-related gene expression., [RefSeq, PubMed]; FGF-16 employs a unique bipartite signal sequence that is not cleaved, although it shares the same secretory machinery used by secreted proteins with cleavable signal sequences., [RefSeq, PubMed]; Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008083 growth factor activity;GO:0005104 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade;GO:0030334 regulation of cell migration;GO:0022008 neurogenesis;GO:0008543 fibroblast growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O54769-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q920Q0-1", "uniprot_id": [ { "id": "PALM_RAT", "url": "https://www.uniprot.org/uniprot/Q920Q0", "type": "external" } ], "mass": 41927.0, "length": 383, "protein_name": "Paralemmin-1", "gene_name": "Palm", "organism": "Rat", "refseq_name": "paralemmin-1", "refseq_ac": [ { "id": "NP_570842", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_570842", "type": "external" } ], "gene_names_uniprotkb": "Palm", "gene_names_refseq": "Palm", "protein_names_uniprotkb": "Paralemmin-1; Paralemmin", "protein_names_refseq": "paralemmin-1", "tax_id": 10116, "disease": "", "pathway": " (rno:170673)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16386234;16847661;18287537;22673903", "class_list": "", "function": "Analysis of the cellular and subcellular localization of paralemmin-1 in the rat tissues is consistent with a role for paralemmin-1 in the formation and stabilization of plasma membrane elaborations, in neurons as well as in other cell types, [RefSeq, PubMed]; Involved in plasma membrane dynamics and cell process formation. Necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner (By similarity)., [UniProtKB]; This study identifies a key role for paralemmin-1 in spine maturation through modulation of filopodia induction., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031750 D3 dopamine receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:0060160 negative regulation of dopamine receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007194 negative regulation of adenylate cyclase activity;GO:0072659 protein localization to plasma membrane;GO:0007010 cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q920Q0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97840-1", "uniprot_id": [ { "id": "LEG9_RAT", "url": "https://www.uniprot.org/uniprot/P97840", "type": "external" } ], "mass": 39946.0, "length": 354, "protein_name": "Galectin-9", "gene_name": "Lgals9", "organism": "Rat", "refseq_name": "galectin-9 isoform 2", "refseq_ac": [ { "id": "NP_037109", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037109", "type": "external" } ], "gene_names_uniprotkb": "Lgals9", "gene_names_refseq": "Lgals9; UAT", "protein_names_uniprotkb": "Galectin-9; 36 kDa beta-galactoside-binding lectin; Gal-9; UAT; Urate transporter/channel", "protein_names_refseq": "36 kDa beta-galactoside-binding lectin; Lectin, galactose binding, soluble 9 (Galectin-9); gal-9; galectin-9 isoform 2; lectin, galactoside-binding, soluble, 9; urate transporter/channel", "tax_id": 10116, "disease": "congenital disorder of glycosylation type I (Disease Ontology:DOID:0050570); congenital disorder of glycosylation Ie (Disease Ontology:DOID:0080557)", "pathway": " (rno:25476)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "16740401;21454685;25158758;25264706;32865657;38527407;8995305;9038233", "class_list": "", "function": "Binds galactosides (By similarity). Has high affinity for the Forssman pentasaccharide (By similarity). Ligand for HAVCR2/TIM3 (By similarity). Binding to HAVCR2 induces T-helper type 1 lymphocyte (Th1) death (By similarity). Also stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth (By similarity). Ligand for P4HB; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (By similarity). Ligand for CD44; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (By similarity). Promotes ability of mesenchymal stromal cells to suppress T-cell proliferation (By similarity). Expands regulatory T-cells and induces cytotoxic T-cell apoptosis following virus infection (By similarity). Activates ERK1/2 phosphorylation inducing cytokine (IL-6, IL-8, IL-12) and chemokine (CCL2) production in mast and dendritic cells (By similarity). Inhibits degranulation and induces apoptosis of mast cells (By similarity). Induces maturation and migration of dendritic cells (By similarity). Inhibits natural killer (NK) cell function (By similarity). Can transform NK cell phenotype from peripheral to decidual during pregnancy (By similarity). Astrocyte derived galectin-9 enhances microglial TNF production (PubMed:25158758). May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. May provide the molecular basis for urate flux across cell membranes, allowing urate that is formed during purine metabolism to efflux from cells and serving as an electrogenic transporter that plays an important role in renal and gastrointestinal urate excretion (PubMed:8995305). Highly selective to the anion urate (PubMed:8995305)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; Galectin-9 Promotes Neuronal Restoration via Binding TLR-4 in a Rat Intracerebral Hemorrhage Model., [RefSeq, PubMed]; Galectin-9 and Tim-3 are upregulated in response to microglial activation induced by the peptide Amyloid-beta (25-35)., [RefSeq, PubMed]; Osteoclasts and osteoclast precursors express Tim-3, and osteoclast differentiation is negatively regulated by its ligand galectin-9., [RefSeq, PubMed]; The presented results on galectin-5 relative to galectin-9 intimate distinct functions especially in erythropoiesis and imply currently unknown mechanisms to compensate its absence from the galectin network in other mammals., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O08588;O35866", "ec_number_list": [], "go_molecular_function": "GO:0070492 oligosaccharide binding;GO:0005102 signaling receptor binding;GO:0019899 enzyme binding;GO:0030246 carbohydrate binding;GO:0043539 protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0032736 positive regulation of interleukin-13 production;GO:2001200 positive regulation of dendritic cell differentiation;GO:0032834 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response;GO:0043032 positive regulation of macrophage activation;GO:0032823 regulation of natural killer cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P97840-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88767-1", "uniprot_id": [ { "id": "PARK7_RAT", "url": "https://www.uniprot.org/uniprot/O88767", "type": "external" } ], "mass": 19974.0, "length": 189, "protein_name": "Parkinson disease protein 7 homolog", "gene_name": "Park7", "organism": "Rat", "refseq_name": "Parkinson disease protein 7 homolog isoform 2", "refseq_ac": [ { "id": "NP_001264179", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264179", "type": "external" } ], "gene_names_uniprotkb": "Park7; Cap1", "gene_names_refseq": "CAP1; DJ-1; Dj1; Park7; SP22", "protein_names_uniprotkb": "Parkinson disease protein 7 homolog; 3.1.2.-; 3.5.1.-; 3.5.1.124; Contraception-associated protein 1; DJ-1; Fertility protein SP22; Maillard deglycase; Parkinsonism-associated deglycase; Protein CAP1; Protein DJ-1; Protein/nucleic acid deglycase DJ-1", "protein_names_refseq": "Parkinson disease (autosomal recessive, early onset) 7; Parkinson disease protein 7 homolog isoform 2; contraception-associated protein 1; fertility protein SP22; maillard deglycase; parkinson disease protein 7 homolog; parkinson protein 7; protein DJ-1; protein deglycase DJ-1; protein/nucleic acid deglycase DJ-1", "tax_id": 10116, "disease": "Parkinson's disease 7 (Disease Ontology:DOID:0060370); early-onset Parkinson's disease (Disease Ontology:DOID:0060894); Parkinsonism (Disease Ontology:DOID:0080855); Parkinson's disease (Disease Ontology:DOID:14330); middle cerebral artery infarction (Disease Ontology:DOID:3525); cerebral infarction (Disease Ontology:DOID:3526); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (rno:117287); (R-RNO-3899300); (R-RNO-9646399)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10022524;23847046;31250274;31536960;34502162;37165139;37674036;38007588;38508437;38531963;38698453;9733139;9792810", "class_list": "", "function": "A Complex Interplay of DJ-1, LRRK2, and Nrf2 in the Regulation of Mitochondrial Function in Cypermethrin-Induced Parkinsonism., [RefSeq, PubMed]; DJ-1 preserves ischemic postconditioning-induced cardioprotection in STZ-induced type 1 diabetic rats: role of PTEN and DJ-1 subcellular translocation. Publication Status: Online-Only, [RefSeq, PubMed]; In the Rat Midbrain, SG2NA and DJ-1 have Common Interactome, Including Mitochondrial Electron Transporters that are Comodulated Under Oxidative Stress. Review article Erratum:[Cell Mol Neurobiol. 2023 Oct;43(7):3081. doi: 10.1007/s10571-023-01369-x. PMID: 37278863], [RefSeq, PubMed]; Involvement of DJ-1 in the pathogenesis of intervertebral disc degeneration via hexokinase 2-mediated mitophagy., [RefSeq, PubMed]; Oxidized DJ-1 activates the p-IKK/NF-kappaB/Beclin1 pathway by binding PTEN to induce autophagy and exacerbate myocardial ischemia-reperfusion injury., [RefSeq, PubMed]; Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) that cause irreversible damage. Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA. Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated to reversing methylglyoxal and glyoxal damage via nucleotide sanitization and direct nucleic acid repair. Also displays an apparent glyoxalase activity that in fact reflects its deglycase activity. Plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox-sensitive chaperone and protease; functions probably related to its primary function. It is involved in neuroprotective mechanisms like the stabilization of NFE2L2 and PINK1 proteins, male fertility as a positive regulator of androgen signaling pathway as well as cell growth and transformation through, for instance, the modulation of NF-kappa-B signaling pathway. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death. Required for correct mitochondrial morphology and function as well as for autophagy of dysfunctional mitochondria. Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking. Regulates astrocyte inflammatory responses, may modulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells (By similarity). In pancreatic islets, involved in the maintenance of mitochondrial reactive oxygen species (ROS) levels and glucose homeostasis in an age- and diet dependent manner. Protects pancreatic beta cells from cell death induced by inflammatory and cytotoxic setting (By similarity). Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress. Metal-binding protein able to bind copper as well as toxic mercury ions, enhances the cell protection mechanism against induced metal toxicity (By similarity). In macrophages, interacts with the NADPH oxidase subunit NCF1 to direct NADPH oxidase-dependent ROS production, and protects against sepsis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.124", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" } ], "go_molecular_function": "GO:1990422 glyoxalase (glycolic acid-forming) activity;GO:0003713 transcription coactivator activity;GO:0003729 mRNA binding;GO:0005102 signaling receptor binding;GO:0008047 enzyme activator activity", "go_cellular_component": "GO:0061827 sperm head;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:1903427 negative regulation of reactive oxygen species biosynthetic process;GO:1903376 regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway;GO:0061727 methylglyoxal catabolic process to lactate;GO:0140041 cellular detoxification of methylglyoxal;GO:1905259 negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "O88767-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11730-1", "uniprot_id": [ { "id": "KCC2G_RAT", "url": "https://www.uniprot.org/uniprot/P11730", "type": "external" } ], "mass": 59038.0, "length": 527, "protein_name": "Calcium/calmodulin-dependent protein kinase type II subunit gamma", "gene_name": "Camk2g", "organism": "Rat", "refseq_name": "calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 10", "refseq_ac": [ { "id": "NP_598289", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598289", "type": "external" } ], "gene_names_uniprotkb": "Camk2g", "gene_names_refseq": "Camk2g", "protein_names_uniprotkb": "Calcium/calmodulin-dependent protein kinase type II subunit gamma; 2.7.11.17; CaM kinase II subunit gamma; CaMK-II subunit gamma", "protein_names_refseq": "Ca+2/calmodulin-dependent protein kinase II gamma; caM kinase II subunit gamma; caM-kinase II gamma chain; caMK-II subunit gamma; calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma; calcium/calmodulin-dependent protein kinase type II gamma chain; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 10; calcium/calmodulin-dependent protein kinase type II subunit gamma-like; calcium/calmodulin-dependent protein kinase type II subunit gamma", "tax_id": 10116, "disease": "autosomal dominant intellectual developmental disorder 59 (Disease Ontology:DOID:0061033); heart conduction disease (Disease Ontology:DOID:10273); malignant astrocytoma (Disease Ontology:DOID:3069)", "pathway": " (rno:171140); (R-RNO-3371571); (R-RNO-399719); (R-RNO-438066); (R-RNO-5578775); (R-RNO-5673000); (R-RNO-5673001); (R-RNO-877300); (R-RNO-936837)", "pathway_count": 9, "publication_count": 9, "publication_id_list": "16891908;22673903;2846534;31518169;32553080;32645222;37037067;38843836;8172610", "class_list": "", "function": "Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity (By similarity). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin (By similarity). In the central nervous system, it is involved in the regulation of neurite formation and arborization. It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Cx43 overexpression reduce the incidence of obstructive sleep apnea associated atrial fibrillation via the CaMKgamma/HIF-1 axis., [RefSeq, PubMed]; Inhibition of MicroRNA 219 Expression Protects Synaptic Plasticity via Activating NMDAR1, CaMKIIgamma, and p-CREB after Microwave Radiation., [RefSeq, PubMed]; MicroRNA-219a-5p-mediated inhibition of CaMKIIgamma facilitates vestibular compensation in acute vertigo by promoting protein kinase C expression., [RefSeq, PubMed]; Thymine DNA glycosylase plays a key role in regulating CaMKIIgamma expression in vascular smooth muscle cells through promoter cytosine methylation/demethylation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q64003;Q64004", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "7.2.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.10", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0014069 postsynaptic density", "go_biological_process": "GO:1901897 regulation of relaxation of cardiac muscle;GO:0006979 response to oxidative stress;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0048169 regulation of long-term neuronal synaptic plasticity", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P11730-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18418-1", "uniprot_id": [ { "id": "CALR_RAT", "url": "https://www.uniprot.org/uniprot/P18418", "type": "external" } ], "mass": 47995.0, "length": 416, "protein_name": "Calreticulin", "gene_name": "Calr", "organism": "Rat", "refseq_name": "calreticulin precursor", "refseq_ac": [ { "id": "NP_071794", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071794", "type": "external" } ], "gene_names_uniprotkb": "Calr", "gene_names_refseq": "Calr", "protein_names_uniprotkb": "Calreticulin; CABP3; CALBP; CRP55; Calcium-binding protein 3; Calregulin; ERp60; Endoplasmic reticulum resident protein 60; HACBP", "protein_names_refseq": "CABP3; CALBP; CRP55; ERp60; HACBP; calcium-binding protein 3; calregulin; calreticulin precursor; endoplasmic reticulum resident protein 60", "tax_id": 10116, "disease": "vitamin B12 deficiency (Disease Ontology:DOID:0050731); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); stomach cancer (Disease Ontology:DOID:10534); lung cancer (Disease Ontology:DOID:1324); Parkinson's disease (Disease Ontology:DOID:14330); colon carcinoma (Disease Ontology:DOID:1520); neuroendocrine tumor (Disease Ontology:DOID:169); colon cancer (Disease Ontology:DOID:219); essential thrombocythemia (Disease Ontology:DOID:2224); thrombocytosis (Disease Ontology:DOID:2228); ovarian cancer (Disease Ontology:DOID:2394); gallbladder cancer (Disease Ontology:DOID:3121); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); myelofibrosis (Disease Ontology:DOID:4971); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); Burkitt lymphoma (Disease Ontology:DOID:8584); sideroblastic anemia (Disease Ontology:DOID:8955); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (rno:64202); (R-RNO-3000480); (R-RNO-901042); (R-RNO-983170)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "11248044;11842220;12270713;12782144;1497655;2241926;2395661;29393594;34638846;7876339;8251535;8453984", "class_list": "", "function": "Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (By similarity). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Possible Roles of Calreticulin in Uterine Decidualization and Receptivity in Rats and Humans. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 25, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P10452", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0005178 integrin binding;GO:0005506 iron ion binding;GO:0051082 unfolded protein binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:0008284 positive regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0045665 negative regulation of neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P18418-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYE2-1", "uniprot_id": [ { "id": "SHLB1_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYE2", "type": "external" } ], "mass": 40787.0, "length": 365, "protein_name": "Endophilin-B1", "gene_name": "Sh3glb1", "organism": "Rat", "refseq_name": "endophilin-B1 isoform 1", "refseq_ac": [ { "id": "NP_001011929", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011929", "type": "external" } ], "gene_names_uniprotkb": "Sh3glb1", "gene_names_refseq": "Sh3glb1", "protein_names_uniprotkb": "Endophilin-B1; SH3 domain-containing GRB2-like protein B1", "protein_names_refseq": "SH3 domain-containing GRB2-like protein B1; SH3-domain GRB2-like B1 (endophilin); SH3-domain GRB2-like endophilin B1; endophilin-B1 isoform 1; endophilin-B1", "tax_id": 10116, "disease": "", "pathway": " (rno:292156)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11604418;26253702", "class_list": "", "function": "Bif-1 was implicated as a novel target of cerebral ischemia reperfusion injury and played a neuroprotective role by promoting cell survival., [RefSeq, PubMed]; May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion. Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation. Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2). Associated with PI3KC3-C2 during autophagy may regulate the trafficking of ATG9A from the Golgi complex to the peripheral cytoplasm for the formation of autophagosomes by inducing Golgi membrane tubulation and fragmentation. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005504 fatty acid binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042171 lysophosphatidic acid acyltransferase activity;GO:0042803 protein homodimerization activity;GO:0141038 phosphatidylinositol 3-kinase activator activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0000421 autophagosome membrane;GO:0005737 cytoplasm;GO:0005741 mitochondrial outer membrane;GO:0005769 early endosome", "go_biological_process": "GO:2000641 regulation of early endosome to late endosome transport;GO:1903861 positive regulation of dendrite extension;GO:0006654 phosphatidic acid biosynthetic process;GO:0006897 endocytosis;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6AYE2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32089-1", "uniprot_id": [ { "id": "TXTP_RAT", "url": "https://www.uniprot.org/uniprot/P32089", "type": "external" } ], "mass": 33835.0, "length": 311, "protein_name": "Tricarboxylate transport protein, mitochondrial", "gene_name": "Slc25a1", "organism": "Rat", "refseq_name": "tricarboxylate transport protein, mitochondrial precursor", "refseq_ac": [ { "id": "NP_059003", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059003", "type": "external" } ], "gene_names_uniprotkb": "Slc25a1; Slc20a3", "gene_names_refseq": "Cic; Ctp; Slc20a3; Slc25a1", "protein_names_uniprotkb": "Tricarboxylate transport protein, mitochondrial; CIC; CTP; Citrate carrier; Citrate transport protein; Solute carrier family 25 member 1; Tricarboxylate carrier protein", "protein_names_refseq": "citrate carrier; citrate transport protein; citrate transporter) member 1; mitochondrial tricarboxylate carrier; solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1; tricarboxylate transport protein, mitochondrial precursor; tricarboxylate transport protein, mitochondrial", "tax_id": 10116, "disease": "2-hydroxyglutaric aciduria (Disease Ontology:DOID:0050573); chromosome 22q11.2 deletion syndrome, distal (Disease Ontology:DOID:0060413); combined D-2- and L-2-hydroxyglutaric aciduria (Disease Ontology:DOID:0111619); DiGeorge syndrome (Disease Ontology:DOID:11198); congenital myasthenic syndrome (Disease Ontology:DOID:3635); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (rno:29743); (R-RNO-428643)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "12488104;22249025;2804096;38843836;8514800", "class_list": "", "function": "Binding of PPRE of CiC promoter by PPARalpha and PPARgammain vivo, [RefSeq, PubMed]; Mitochondrial electroneutral antiporter that exports citrate from the mitochondria into the cytosol in exchange for malate. Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis-aconitate and to a lesser extent trans-aconitate, maleate and succinate. Substrate exchange across the membrane occurs consecutively with one substrate being transported first, then dissociating from the substrate binding site before the second substrate binds for transport in the opposite direction. In the cytoplasm, citrate plays important roles in fatty acid and sterol synthesis, regulation of glycolysis, protein acetylation, and other physiopathological processes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; This gene encodes a member of the mitochondrial carrier family. The encoded protein is responsible for the movement of tricarboxylates, such as citrate, across the inner mitochondrial membrane. It is essential to the bioenergetics of hepatic cells, supplying the cytoplasm with a carbon source for fatty acid and sterol biosynthesis, and NAD+ for the glycolytic pathway. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q498T8", "ec_number_list": [], "go_molecular_function": "GO:0015297 antiporter activity;GO:0015137 citrate transmembrane transporter activity;GO:0015142 tricarboxylic acid transmembrane transporter activity;GO:0071913 citrate secondary active transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0006843 mitochondrial citrate transmembrane transport;GO:0110076 negative regulation of ferroptosis;GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P32089-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6MG08-1", "uniprot_id": [ { "id": "ABCF1_RAT", "url": "https://www.uniprot.org/uniprot/Q6MG08", "type": "external" } ], "mass": 95252.0, "length": 839, "protein_name": "ATP-binding cassette sub-family F member 1", "gene_name": "Abcf1", "organism": "Rat", "refseq_name": "ATP-binding cassette sub-family F member 1", "refseq_ac": [ { "id": "NP_001103353", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103353", "type": "external" } ], "gene_names_uniprotkb": "Abcf1; Abc50", "gene_names_refseq": "Abc50; Abcf1", "protein_names_uniprotkb": "ATP-binding cassette sub-family F member 1; ATP-binding cassette 50", "protein_names_refseq": "ATP-binding cassette 50; ATP-binding cassette sub-family F member 1; ATP-binding cassette, sub-family F (GCN20), member 1; ATP-binding cassette, subfamily F (GCN20), member 1", "tax_id": 10116, "disease": "", "pathway": " (rno:85493); (R-RNO-382556)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10931828;15060004;22673903", "class_list": "", "function": "Required for efficient Cap- and IRES-mediated mRNA translation initiation. Not involved in the ribosome biogenesis (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9ERQ2", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0008494 translation activator activity;GO:0043022 ribosome binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005840 ribosome", "go_biological_process": "GO:0006413 translational initiation;GO:0006412 translation;GO:0045727 positive regulation of translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6MG08-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08816-1", "uniprot_id": [ { "id": "WASL_RAT", "url": "https://www.uniprot.org/uniprot/O08816", "type": "external" } ], "mass": 54325.0, "length": 501, "protein_name": "Actin nucleation-promoting factor WASL", "gene_name": "Wasl", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Wasl", "gene_names_refseq": "", "protein_names_uniprotkb": "Actin nucleation-promoting factor WASL; N-WASP; Neural Wiskott-Aldrich syndrome protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "atopic dermatitis (Disease Ontology:DOID:3310); Wiskott-Aldrich syndrome (Disease Ontology:DOID:9169)", "pathway": " (rno:682507)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12437929;14676198;22673903;9322739", "class_list": "", "function": "Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex. Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization. Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization (By similarity). Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression. Plays a role in dendrite spine morphogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0042802 identical protein binding;GO:0008092 cytoskeletal protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0010324 membrane invagination;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051301 cell division;GO:0009617 response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O08816-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XHX8-1", "uniprot_id": [ { "id": "SMAP2_RAT", "url": "https://www.uniprot.org/uniprot/Q5XHX8", "type": "external" } ], "mass": 43448.0, "length": 378, "protein_name": "Sperm microtubule associated protein 2", "gene_name": "Spmap2", "organism": "Rat", "refseq_name": "sperm microtubule associated protein 2 isoform 1", "refseq_ac": [ { "id": "NP_001013120", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013120", "type": "external" } ], "gene_names_uniprotkb": "Spmap2; Theg", "gene_names_refseq": "Spmap2; Theg", "protein_names_uniprotkb": "Sperm microtubule associated protein 2; Testicular haploid expressed gene protein", "protein_names_refseq": "sperm microtubule associated protein 2 isoform 1; testicular haploid expressed gene protein; theg spermatid protein", "tax_id": 10116, "disease": "", "pathway": " (rno:299599)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "May be involved (but not essential) in spermatogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XHX8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61972-1", "uniprot_id": [ { "id": "NTF2_RAT", "url": "https://www.uniprot.org/uniprot/P61972", "type": "external" } ], "mass": 14478.0, "length": 127, "protein_name": "Nuclear transport factor 2", "gene_name": "Nutf2", "organism": "Rat", "refseq_name": "nuclear transport factor 2", "refseq_ac": [ { "id": "NP_001007630", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007630", "type": "external" } ], "gene_names_uniprotkb": "Nutf2; Ntf2; Nutf2l1", "gene_names_refseq": "NTF2; Nutf2", "protein_names_uniprotkb": "Nuclear transport factor 2; NTF-2", "protein_names_refseq": "NTF-2; nuclear transport factor 2", "tax_id": 10116, "disease": "diabetic retinopathy (Disease Ontology:DOID:8947)", "pathway": " (rno:291981)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10543952;11038179;11846560;15522285;19404486;8707840;8757804;8812990;9368653;9533885;9822603", "class_list": "", "function": "Has a role in nuclear-cytoplasmic transport of proteins and mRNAs., [UniProtKB, UniProtKB]; Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; NTF2 is a potential mediator of retinal vasculature integrity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 17, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P13662", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0031267 small GTPase binding;GO:0017056 structural constituent of nuclear pore;GO:0061608 nuclear import signal receptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0031965 nuclear membrane;GO:0005637 nuclear inner membrane;GO:0044613 nuclear pore central transport channel", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0006611 protein export from nucleus;GO:0051028 mRNA transport;GO:0090204 protein localization to nuclear pore;GO:1904046 negative regulation of vascular endothelial growth factor production", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P61972-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZZC3-1", "uniprot_id": [ { "id": "KLH22_RAT", "url": "https://www.uniprot.org/uniprot/D3ZZC3", "type": "external" } ], "mass": 71774.0, "length": 634, "protein_name": "Kelch-like protein 22", "gene_name": "Klhl22", "organism": "Rat", "refseq_name": "kelch-like protein 22", "refseq_ac": [ { "id": "NP_001100549", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100549", "type": "external" } ], "gene_names_uniprotkb": "Klhl22", "gene_names_refseq": "Klhl22; RGD1306288", "protein_names_uniprotkb": "Kelch-like protein 22", "protein_names_refseq": "kelch-like 22; kelch-like protein 22", "tax_id": 10116, "disease": "", "pathway": " (rno:303792); (R-RNO-8951664); (R-RNO-983168)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "16641100", "class_list": "", "function": "Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation. The BCR(KLHL22) ubiquitin ligase complex is also responsible for the amino acid-stimulated 'Lys-48' polyubiquitination and proteasomal degradation of DEPDC5. Through the degradation of DEPDC5, releases the GATOR1 complex-mediated inhibition of the TORC1 pathway. It is therefore an amino acid-dependent activator within the amino acid-sensing branch of the TORC1 pathway, indirectly regulating different cellular processes including cell growth and autophagy., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D4A9W5", "ec_number_list": [], "go_molecular_function": "GO:0071889 14-3-3 protein binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005764 lysosome", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0002842 positive regulation of T cell mediated immune response to tumor cell;GO:0030307 positive regulation of cell growth;GO:0051301 cell division;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZZC3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35525-1", "uniprot_id": [ { "id": "CLCN2_RAT", "url": "https://www.uniprot.org/uniprot/P35525", "type": "external" } ], "mass": 99328.0, "length": 907, "protein_name": "Chloride channel protein 2", "gene_name": "Clcn2", "organism": "Rat", "refseq_name": "chloride channel protein 2", "refseq_ac": [ { "id": "NP_058833", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058833", "type": "external" } ], "gene_names_uniprotkb": "Clcn2", "gene_names_refseq": "ClC-2; Clcn2", "protein_names_uniprotkb": "Chloride channel protein 2; ClC-2", "protein_names_refseq": "chloride channel 2; chloride channel protein 2; chloride channel, voltage-sensitive 2", "tax_id": 10116, "disease": "leukodystrophy (Disease Ontology:DOID:10579); cystic fibrosis (Disease Ontology:DOID:1485); myopathy (Disease Ontology:DOID:423); primary hyperaldosteronism (Disease Ontology:DOID:446)", "pathway": " (rno:29232); (R-RNO-2672351)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "11068136;12163466;1311421;1334533;22405205;22673903;28255270;38418461;8816717", "class_list": "", "function": "ClC-2 and caspase-3 were induced by GDM, which resulted in apoptosis and myelination inhibition. The effect was caused by repressing PI3K-Akt signaling pathway. Application of ClC-2 inhibitor DIDS showed protective effects on cerebral white matter damage stimulated by high glucose concentration. Publication Status: Online-Only, [RefSeq, PubMed]; NEDD4-2 and the CLC-2 channel regulate neuronal excitability in the pathogenesis of mesial temporal lobe epilepsy. Publication Status: Online-Only, [RefSeq, PubMed]; Voltage-gated and osmosensitive chloride channel. Forms a homodimeric channel where each subunit has its own ion conduction pathway. Conducts double-barreled currents controlled by two types of gates, two fast glutamate gates that control each subunit independently and a slow common gate that opens and shuts off both subunits simultaneously. Displays inward rectification currents activated upon membrane hyperpolarization and extracellular hypotonicity (PubMed:12163466, PubMed:1311421, PubMed:1334533, PubMed:22405205). Contributes to chloride conductance involved in neuron excitability. In hippocampal neurons, generates a significant part of resting membrane conductance and provides an additional chloride efflux pathway to prevent chloride accumulation in dendrites upon GABA receptor activation. In glia, associates with the auxiliary subunit HEPACAM/GlialCAM at astrocytic processes and myelinated fiber tracts where it may regulate transcellular chloride flux buffering extracellular chloride and potassium concentrations (By similarity) (PubMed:8816717). Regulates aldosterone production in adrenal glands. The opening of CLCN2 channels at hyperpolarized membrane potentials in the glomerulosa causes cell membrane depolarization, activation of voltage-gated calcium channels and increased expression of aldosterone synthase, the rate-limiting enzyme for aldosterone biosynthesis (By similarity). Contributes to chloride conductance in retinal pigment epithelium involved in phagocytosis of shed photoreceptor outer segments and photoreceptor renewal (By similarity). Conducts chloride currents at the basolateral membrane of epithelial cells with a role in chloride reabsorption rather than secretion (By similarity). Permeable to small monovalent anions with chloride > thiocyanate > bromide > nitrate > iodide ion selectivity (By similarity) (PubMed:1311421, PubMed:22405205, PubMed:8816717)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0072320 volume-sensitive chloride channel activity;GO:0017081 chloride channel regulator activity;GO:0005247 voltage-gated chloride channel activity;GO:0008308 voltage-gated monoatomic anion channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton;GO:0016323 basolateral plasma membrane;GO:0030425 dendrite;GO:0043204 perikaryon", "go_biological_process": "GO:0071476 cellular hypotonic response;GO:1902943 positive regulation of voltage-gated chloride channel activity;GO:0030322 stabilization of membrane potential;GO:0006911 phagocytosis, engulfment;GO:0048714 positive regulation of oligodendrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P35525-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FVR6-1", "uniprot_id": [ { "id": "CMS1_RAT", "url": "https://www.uniprot.org/uniprot/Q5FVR6", "type": "external" } ], "mass": 31502.0, "length": 276, "protein_name": "Protein CMSS1", "gene_name": "Cmss1", "organism": "Rat", "refseq_name": "protein CMSS1", "refseq_ac": [ { "id": "NP_001013888", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013888", "type": "external" } ], "gene_names_uniprotkb": "Cmss1", "gene_names_refseq": "Cmss1; RGD1309437", "protein_names_uniprotkb": "Protein CMSS1; Cms1 ribosomal small subunit homolog", "protein_names_refseq": "protein CMSS1; uncharacterized protein C3orf26 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:288176)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5FVR6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q75Q41-1", "uniprot_id": [ { "id": "TOM22_RAT", "url": "https://www.uniprot.org/uniprot/Q75Q41", "type": "external" } ], "mass": 15491.0, "length": 142, "protein_name": "Mitochondrial import receptor subunit TOM22 homolog", "gene_name": "Cby1; Tomm22", "organism": "Rat", "refseq_name": "mitochondrial import receptor subunit TOM22 homolog", "refseq_ac": [ { "id": "NP_997679", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997679", "type": "external" } ], "gene_names_uniprotkb": "Cby1; Tomm22; Cby1; Tom22", "gene_names_refseq": "TOM22; Tomm22; rTOM22", "protein_names_uniprotkb": "Mitochondrial import receptor subunit TOM22 homolog; Translocase of outer membrane 22 kDa subunit homolog; rTOM22", "protein_names_refseq": "mitochondrial import receptor subunit TOM22 homolog; translocase of outer membrane 22 kDa subunit homolog; translocase of outer mitochondrial membrane 22 homolog", "tax_id": 10116, "disease": "otitis media (Disease Ontology:DOID:10754); primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": " (rno:300075); (R-RNO-5205685)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "14985332;15923182;19401463;22673903;33526603", "class_list": "", "function": "A Novel Mitochondrial Complex of Aldosterone Synthase, Steroidogenic Acute Regulatory Protein, and Tom22 Synthesizes Aldosterone in the Rat Heart. Erratum:[J Pharmacol Exp Ther. 2021 Apr;377(1):200. doi: 10.1124/jpet.120.000365err. PMID: 33757981], [RefSeq, PubMed]; Analysis of signals that target rat TOM22 to the mitochondrial outer membrane and assembly into the TOM complex in cultured mammalian cells., [RefSeq, PubMed]; Central receptor component of the translocase of the outer membrane of mitochondria (TOM) complex essential for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOMM20, functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore. The TOM complex associates with the ion channel VDAC2 and PINK1 kinase at depolarized mitochondria, this interaction stabilizes PINK1 at the outer mitochondrial membrane and triggers downstream mitophagy by the recruitment of the E3 ubiquitin ligase PRKN. Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008320 protein transmembrane transporter activity;GO:0030943 mitochondrion targeting sequence binding;GO:0042803 protein homodimerization activity;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0016020 membrane;GO:0005742 mitochondrial outer membrane translocase complex;GO:0005634 nucleus;GO:0005813 centrosome", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0043065 positive regulation of apoptotic process;GO:0006626 protein targeting to mitochondrion;GO:0030150 protein import into mitochondrial matrix;GO:0051204 protein insertion into mitochondrial membrane", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q75Q41-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A9ZSY0-1", "uniprot_id": [ { "id": "CNTLN_RAT", "url": "https://www.uniprot.org/uniprot/A9ZSY0", "type": "external" } ], "mass": 82721.0, "length": 721, "protein_name": "Centlein", "gene_name": "Cntln", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cntln", "gene_names_refseq": "", "protein_names_uniprotkb": "Centlein; Centrosomal protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:679640)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "18086554", "class_list": "", "function": "Required for centrosome cohesion and recruitment of CEP68 to centrosomes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005814 centriole;GO:0120212 sperm head-tail coupling apparatus", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007338 single fertilization;GO:0032880 regulation of protein localization;GO:0008104 intracellular protein localization;GO:0010457 centriole-centriole cohesion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A9ZSY0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62986-1", "uniprot_id": [ { "id": "RL40_RAT", "url": "https://www.uniprot.org/uniprot/P62986", "type": "external" } ], "mass": 14728.0, "length": 128, "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein", "gene_name": "Kxd1; Uba52", "organism": "Rat", "refseq_name": "ubiquitin-ribosomal protein eL40 fusion protein", "refseq_ac": [ { "id": "NP_113875", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113875", "type": "external" } ], "gene_names_uniprotkb": "Kxd1; Uba52; Uba52; Ubcep2", "gene_names_refseq": "Rps27a; Uba52; Ubb", "protein_names_uniprotkb": "Ubiquitin-ribosomal protein eL40 fusion protein; 60S ribosomal protein L40; CEP52; Ubiquitin A-52 residue ribosomal protein fusion product 1", "protein_names_refseq": "60S ribosomal protein L40; CEP52; ubiquitin-60S ribosomal protein L40; ubiquitin-ribosomal protein eL40 fusion protein", "tax_id": 10116, "disease": "colon carcinoma (Disease Ontology:DOID:1520)", "pathway": " (rno:64156); (R-RNO-110312); (R-RNO-110314); (R-RNO-110320); (R-RNO-1169091); (R-RNO-1234176); (R-RNO-1253288); (R-RNO-1295596); (R-RNO-1358803); (R-RNO-156827); (R-RNO-168638); (R-RNO-174048); (R-RNO-174084); (R-RNO-174113); (R-RNO-174154); (R-RNO-174178); (R-RNO-174184); (R-RNO-179409); (R-RNO-1799339); (R-RNO-182971); (R-RNO-187577); (R-RNO-195253); (R-RNO-201681); (R-RNO-202424); (R-RNO-205043); (R-RNO-209543); (R-RNO-209560); (R-RNO-2122948); (R-RNO-2173788); (R-RNO-2173791); (R-RNO-2173795); (R-RNO-2173796); (R-RNO-2467813); (R-RNO-2559580); (R-RNO-2559582); (R-RNO-2559585); (R-RNO-2565942); (R-RNO-2672351); (R-RNO-2871837); (R-RNO-3134975); (R-RNO-349425); (R-RNO-3769402); (R-RNO-382556); (R-RNO-445989); (R-RNO-450302); (R-RNO-450321); (R-RNO-450408); (R-RNO-4608870); (R-RNO-4641257); (R-RNO-4641258); (R-RNO-4641263); (R-RNO-5205685); (R-RNO-532668); (R-RNO-5357905); (R-RNO-5357956); (R-RNO-5358346); (R-RNO-5607761); (R-RNO-5607764); (R-RNO-5610780); (R-RNO-5610785); (R-RNO-5632684); (R-RNO-5654726); (R-RNO-5654727); (R-RNO-5654732); (R-RNO-5654733); (R-RNO-5655862); (R-RNO-5656121); (R-RNO-5656169); (R-RNO-5658442); (R-RNO-5668541); (R-RNO-5675221); (R-RNO-5675482); (R-RNO-5676590); (R-RNO-5684264); (R-RNO-5685942); (R-RNO-5687128); (R-RNO-5689603); (R-RNO-5689877); (R-RNO-5689880); (R-RNO-5689896); (R-RNO-5689901); (R-RNO-5693537); (R-RNO-5693565); (R-RNO-5696394); (R-RNO-5696395); (R-RNO-5696397); (R-RNO-5696400); (R-RNO-6781823); (R-RNO-6782135); (R-RNO-6782210); (R-RNO-6783310); (R-RNO-6791226); (R-RNO-6804756); (R-RNO-6804757); (R-RNO-6804760); (R-RNO-6807004); (R-RNO-68867); (R-RNO-68949); (R-RNO-69017); (R-RNO-69231); (R-RNO-69481); (R-RNO-69541); (R-RNO-69601); (R-RNO-72649); (R-RNO-72689); (R-RNO-72695); (R-RNO-72702); (R-RNO-72706); (R-RNO-75815); (R-RNO-8849469); (R-RNO-8852276); (R-RNO-8854050); (R-RNO-8856825); (R-RNO-8856828); (R-RNO-8863795); (R-RNO-8866427); (R-RNO-8866652); (R-RNO-8866654); (R-RNO-8939236); (R-RNO-8941858); (R-RNO-8948747); (R-RNO-8948751); (R-RNO-8951664); (R-RNO-901032); (R-RNO-9013507); (R-RNO-9020702); (R-RNO-9033241); (R-RNO-909733); (R-RNO-912631); (R-RNO-917729); (R-RNO-917937); (R-RNO-936440); (R-RNO-936964); (R-RNO-937039); (R-RNO-937041); (R-RNO-937042); (R-RNO-937072); (R-RNO-9645460); (R-RNO-9646399); (R-RNO-9648002); (R-RNO-9664873); (R-RNO-9705462); (R-RNO-975144); (R-RNO-975163); (R-RNO-9755511); (R-RNO-9758274); (R-RNO-975956); (R-RNO-975957); (R-RNO-9762114); (R-RNO-9766229); (R-RNO-9770562); (R-RNO-9824878); (R-RNO-983168); (R-RNO-9861718); (R-RNO-9929356); (R-RNO-9929491); (R-RNO-9931269); (R-RNO-9931295); (R-RNO-9932298); (R-RNO-9954709); (R-RNO-9954714); (R-RNO-9954716); (R-RNO-9958810); (R-RNO-9958825)", "pathway_count": 164, "publication_count": 9, "publication_id_list": "12042320;33609735;34502162;36755387;38843836;7488009;8031840;8670124;9219540", "class_list": "", "function": "Component of the 60S subunit of the ribosome. Ribosomal protein L40 is essential for translation of a subset of cellular transcripts, and especially for cap-dependent translation of vesicular stomatitis virus mRNAs., [UniProtKB, UniProtKB]; Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling., [UniProtKB, UniProtKB]; Males and females differ in the regulation and engagement of, but not requirement for, protein degradation in the amygdala during fear memory formation., [RefSeq, PubMed]; UBA52 Attunes VDAC1-Mediated Mitochondrial Dysfunction and Dopaminergic Neuronal Death., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P02248;P02249;P02250;P14793;P62989;Q29120;Q63446;Q91887;Q91888", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0031386 protein tag activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0045202 synapse;GO:0022626 cytosolic ribosome;GO:0098556 cytoplasmic side of rough endoplasmic reticulum membrane", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0019941 modification-dependent protein catabolic process;GO:0017085 response to insecticide;GO:0002181 cytoplasmic translation;GO:0032418 lysosome localization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P62986-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P60531-1", "uniprot_id": [ { "id": "TSKS_RAT", "url": "https://www.uniprot.org/uniprot/P60531", "type": "external" } ], "mass": 63532.0, "length": 585, "protein_name": "Testis-specific serine kinase substrate", "gene_name": "Tsks", "organism": "Rat", "refseq_name": "testis-specific serine kinase substrate isoform 3", "refseq_ac": [ { "id": "NP_954519", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_954519", "type": "external" } ], "gene_names_uniprotkb": "Tsks; Stk22s1", "gene_names_refseq": "Stk22s1; Tsks", "protein_names_uniprotkb": "Testis-specific serine kinase substrate; STK22 substrate 1; Testis-specific kinase substrate", "protein_names_refseq": "STK22 substrate 1; serine/threonine kinase 22 substrate 1; testis-specific kinase substrate; testis-specific serine kinase substrate isoform 3", "tax_id": 10116, "disease": "", "pathway": " (rno:292890)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "May play a role in testicular physiology, most probably in the process of spermatogenesis or spermatid development., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005814 centriole", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P60531-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KLZ6-1", "uniprot_id": [ { "id": "TKFC_RAT", "url": "https://www.uniprot.org/uniprot/Q4KLZ6", "type": "external" } ], "mass": 59444.0, "length": 578, "protein_name": "Triokinase/FMN cyclase", "gene_name": "Tkfc", "organism": "Rat", "refseq_name": "triokinase/FMN cyclase", "refseq_ac": [ { "id": "NP_001034120", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034120", "type": "external" } ], "gene_names_uniprotkb": "Tkfc; Dak", "gene_names_refseq": "Dak; RGD1311026; Tkfc", "protein_names_uniprotkb": "Triokinase/FMN cyclase; Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing); FAD-AMP lyase (cyclic FMN forming); FMN cyclase; Glycerone kinase; Triokinase; Triose kinase", "protein_names_refseq": "bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing); dihydroxyacetone kinase 2 homolog; triokinase/FMN cyclase", "tax_id": 10116, "disease": "", "pathway": " (rno:361730); (R-RNO-70350)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "11695920;16289032;22673903", "class_list": "", "function": "Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate (PubMed:16289032). Represses IFIH1-mediated cellular antiviral response (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.28", "type": "external" }, { "id": "2.7.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.29", "type": "external" }, { "id": "4.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.15", "type": "external" } ], "go_molecular_function": "GO:0004371 glycerone kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0034012 FAD-AMP lyase (cyclizing) activity;GO:0050354 triokinase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0019563 glycerol catabolic process;GO:0005975 carbohydrate metabolic process;GO:0061624 fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate;GO:0039534 negative regulation of MDA-5 signaling pathway;GO:0045088 regulation of innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q4KLZ6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50137-1", "uniprot_id": [ { "id": "TKT_RAT", "url": "https://www.uniprot.org/uniprot/P50137", "type": "external" } ], "mass": 67644.0, "length": 623, "protein_name": "Transketolase", "gene_name": "Tkt", "organism": "Rat", "refseq_name": "transketolase isoform 4", "refseq_ac": [ { "id": "NP_072114", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_072114", "type": "external" } ], "gene_names_uniprotkb": "Tkt", "gene_names_refseq": "Tkt", "protein_names_uniprotkb": "Transketolase; 2.2.1.1; TK", "protein_names_refseq": "TK; transketolase isoform 4", "tax_id": 10116, "disease": "", "pathway": " (rno:64524); (R-RNO-163754); (R-RNO-71336)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "22673903;25028661;34502162", "class_list": "", "function": "Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results suggest that modulation of transketolase activity might be one of the mechanisms by which thiamine regulates the proliferation of hippocampal progenitor cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.2.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.2.1.1", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0042803 protein homodimerization activity;GO:0005509 calcium ion binding;GO:0030246 carbohydrate binding;GO:0030976 thiamine pyrophosphate binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005777 peroxisome;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane;GO:0005737 cytoplasm", "go_biological_process": "GO:0009052 pentose-phosphate shunt, non-oxidative branch;GO:0040008 regulation of growth;GO:0006098 pentose-phosphate shunt;GO:0046166 glyceraldehyde-3-phosphate biosynthetic process;GO:1901159 D-xylulose 5-phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P50137-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6JUQ6-1", "uniprot_id": [ { "id": "CLVS2_RAT", "url": "https://www.uniprot.org/uniprot/A6JUQ6", "type": "external" } ], "mass": 37916.0, "length": 327, "protein_name": "Clavesin-2", "gene_name": "Clvs2", "organism": "Rat", "refseq_name": "clavesin-2", "refseq_ac": [ { "id": "NP_001397251", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001397251", "type": "external" } ], "gene_names_uniprotkb": "Clvs2; Rlbp1l2", "gene_names_refseq": "Clavesin-2; Clvs2; RGD1306801; Rlbp1l2", "protein_names_uniprotkb": "Clavesin-2; Retinaldehyde-binding protein 1-like 2", "protein_names_refseq": "Retinaldehyde-binding protein 1-like protein 2; clavesin-2; retinaldehyde-binding protein 1-like 2", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283); cancer (Disease Ontology:DOID:162)", "pathway": " (rno:361459); (R-RNO-432720)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "19651769;22673903", "class_list": "", "function": "Required for normal morphology of late endosomes and/or lysosomes in neurons. Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1902936 phosphatidylinositol bisphosphate binding;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005768 endosome;GO:0031901 early endosome membrane;GO:0030136 clathrin-coated vesicle;GO:0005802 trans-Golgi network;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0007040 lysosome organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A6JUQ6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P59824-1", "uniprot_id": [ { "id": "IRPL1_RAT", "url": "https://www.uniprot.org/uniprot/P59824", "type": "external" } ], "mass": 79771.0, "length": 696, "protein_name": "Interleukin-1 receptor accessory protein-like 1", "gene_name": "Il1rapl1", "organism": "Rat", "refseq_name": "interleukin-1 receptor accessory protein-like 1 precursor", "refseq_ac": [ { "id": "NP_808796", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808796", "type": "external" } ], "gene_names_uniprotkb": "Il1rapl1", "gene_names_refseq": "Il1rapl1; Il1rapl", "protein_names_uniprotkb": "Interleukin-1 receptor accessory protein-like 1; 3.2.2.6; IL-1-RAPL-1; IL-1RAPL-1; IL1RAPL-1; X-linked interleukin-1 receptor accessory protein-like 1", "protein_names_refseq": "IL-1-RAPL-1; IL-1RAPL-1; IL1RAPL-1; X-linked interleukin-1 receptor accessory protein-like 1; interleukin-1 receptor accessory protein-like 1 precursor", "tax_id": 10116, "disease": "non-syndromic X-linked intellectual disability 21 (Disease Ontology:DOID:0112022); intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (rno:317553); (R-RNO-388844); (R-RNO-9007892)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "17502602;18801879;20096586", "class_list": "", "function": "IL1RAPL1-related mental retardation could result from a disruption of N-type voltage-gated calcium channels and/or neuronal calcium sensor-1-dependent synaptic and neuronal activities, [RefSeq, PubMed]; Interaction of IL1RAPL1 with PSD-95 discloses a novel pathophysiological mechanism of cognitive impairment associated with alterations of the JNK pathway leading to a mislocalization of PSD-95 and abnormal synaptic organization and function, [RefSeq, PubMed]; May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel (PubMed:17502602). May activate the MAP kinase JNK (By similarity). Plays a role in neurite outgrowth (PubMed:18801879). During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "3.2.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.5", "type": "external" }, { "id": "2.4.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.31", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.4.99.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.20", "type": "external" } ], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating;GO:0016787 hydrolase activity;GO:0004908 interleukin-1 receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030424 axon", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0030182 neuron differentiation;GO:0051965 positive regulation of synapse assembly;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0050775 positive regulation of dendrite morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P59824-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08699-1", "uniprot_id": [ { "id": "LEG3_RAT", "url": "https://www.uniprot.org/uniprot/P08699", "type": "external" } ], "mass": 27202.0, "length": 262, "protein_name": "Galectin-3", "gene_name": "Lgals3", "organism": "Rat", "refseq_name": "galectin-3", "refseq_ac": [ { "id": "NP_114020", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114020", "type": "external" } ], "gene_names_uniprotkb": "Lgals3", "gene_names_refseq": "AGE-R3; CBP30; L-34; Lgals3; gal-3", "protein_names_uniprotkb": "Galectin-3; 35 kDa lectin; CBP 35; Carbohydrate-binding protein 35; Gal-3; Galactose-specific lectin 3; IgE-binding protein; Laminin-binding protein; Lectin L-29; Mac-2 antigen", "protein_names_refseq": "35 kDa lectin; CBP 35; IgE binding protein; carbohydrate-binding protein 35; epsilon BP; galactose-specific lectin 3; galectin-3; igE-binding protein; laminin-binding protein; lectin L-29; lectin galactoside-binding soluble 3 protein; lectin, galactose binding, soluble 3; lectin, galactoside-binding, soluble, 3; mac-2 antigen", "tax_id": 10116, "disease": "COVID-19 (Disease Ontology:DOID:0080600); hypertension (Disease Ontology:DOID:10763); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); aortic valve stenosis (Disease Ontology:DOID:1712); colon cancer (Disease Ontology:DOID:219); brain ischemia (Disease Ontology:DOID:2316); asthma (Disease Ontology:DOID:2841); acute kidney failure (Disease Ontology:DOID:3021); high grade glioma (Disease Ontology:DOID:3070); liver cirrhosis (Disease Ontology:DOID:5082); congestive heart failure (Disease Ontology:DOID:6000); steatotic liver disease (Disease Ontology:DOID:9452); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:83781); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "11121438;15729693;2605254;28744198;2958848;37926077;38561725;3858867;38728287;38989572;8253805", "class_list": "", "function": "Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes (By similarity). Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (PubMed:11121438). When secreted, interacts with NK cell-activating receptor NCR3/NKp30 acting as an inhibitory ligand which antagonizes NK cell attack (By similarity)., [UniProtKB, UniProtKB, PubMed]; Hspb1 and Lgals3 in spinal neurons are closely associated with autophagy following excitotoxicity based on machine learning algorithms. Publication Status: Online-Only, [RefSeq, PubMed]; Inhibition of Galectin-3 in a Rat Model of Epilepsy and Kainate-Activated BV2 Cells Limits Microglial Activation Through the NLRP3/Pyroptosis Pathway., [RefSeq, PubMed]; Role of Galectin-3 in intervertebral disc degeneration: an experimental study. Publication Status: Online-Only, [RefSeq, PubMed]; The detrimental role of galectin-3 and endoplasmic reticulum stress in the cardiac consequences of myocardial ischemia in the context of obesity., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0070492 oligosaccharide binding;GO:0019863 IgE binding;GO:0050785 advanced glycation end-product receptor activity;GO:0042056 chemoattractant activity;GO:0043236 laminin binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0070232 regulation of T cell apoptotic process;GO:0071677 positive regulation of mononuclear cell migration;GO:0045806 negative regulation of endocytosis;GO:0006397 mRNA processing;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P08699-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AY70-1", "uniprot_id": [ { "id": "KANL2_RAT", "url": "https://www.uniprot.org/uniprot/Q6AY70", "type": "external" } ], "mass": 54378.0, "length": 488, "protein_name": "KAT8 regulatory NSL complex subunit 2", "gene_name": "Kansl2", "organism": "Rat", "refseq_name": "KAT8 regulatory NSL complex subunit 2", "refseq_ac": [ { "id": "NP_001004244", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004244", "type": "external" } ], "gene_names_uniprotkb": "Kansl2; LOC103690317; Nsl2", "gene_names_refseq": "Kansl2; RGD1303127", "protein_names_uniprotkb": "KAT8 regulatory NSL complex subunit 2; NSL complex protein NSL2; Non-specific lethal 2 homolog", "protein_names_refseq": "KAT8 regulatory NSL complex subunit 2; NSL complex protein NSL2; non-specific lethal 2 homolog; uncharacterized protein C12orf41 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:300206); (R-RNO-3214847); (R-RNO-9772755)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation. Required for NSL complex stability and for transcription of intraciliary transport genes in both ciliated and non-ciliated cells by regulating histone H4 acetylation at 'Lys-5'- and 'Lys-12' (H4K5ac and H4K12ac). This is necessary for cilium assembly in ciliated cells and for organization of the microtubule cytoskeleton in non-ciliated cells. Required within the NSL complex to maintain nuclear architecture stability by promoting KAT8-mediated acetylation of lamin LMNA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3V7H0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0000123 histone acetyltransferase complex", "go_biological_process": "GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AY70-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08679-1", "uniprot_id": [ { "id": "MARK2_RAT", "url": "https://www.uniprot.org/uniprot/O08679", "type": "external" } ], "mass": 80872.0, "length": 722, "protein_name": "Serine/threonine-protein kinase MARK2", "gene_name": "Mark2", "organism": "Rat", "refseq_name": "serine/threonine-protein kinase MARK2 isoform 1", "refseq_ac": [ { "id": "NP_067731", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067731", "type": "external" } ], "gene_names_uniprotkb": "Mark2", "gene_names_refseq": "Mark2", "protein_names_uniprotkb": "Serine/threonine-protein kinase MARK2; 2.7.11.1; 2.7.11.26; ELKL motif kinase 1; EMK-1; MAP/microtubule affinity-regulating kinase 2", "protein_names_refseq": "ELKL motif kinase 1; EMK-1; EMK1; MAP/microtubule affinity-regulating kinase 2; serine/threonine kinase; serine/threonine-protein kinase MARK2 isoform 1; serine/threonine-protein kinase MARK2", "tax_id": 10116, "disease": "visual impairment and progressive phthisis bulbi (Disease Ontology:DOID:0070356); neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (rno:60328)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "14517247;14741102;15466480;16014608;16257959;16472737;16717194;17442826;18424437;18509032;20071654;22673903;27465397;35971301;38843836;9108484", "class_list": "", "function": "A critical role for MARK2 in overcoming Nogo-66-induced inhibition of axon outgrowth in neurons, [RefSeq, PubMed]; MARK2 and MARK4 Regulate Sertoli Cell BTB Dynamics Through Microtubule and Actin Cytoskeletons., [RefSeq, PubMed]; Serine/threonine-protein kinase. Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU. Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of disheveled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. Phosphorylates UBAC2 at 'Ser-223' during ER stress or starvation-induced autophagy, promoting UBAC2 dimerization and interaction with GABARAP to mediate ER-phagy (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 25, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008289 lipid binding;GO:0048156 tau protein binding", "go_cellular_component": "GO:0045180 basal cortex;GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005884 actin filament", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0006468 protein phosphorylation;GO:0010976 positive regulation of neuron projection development;GO:0035556 intracellular signal transduction;GO:0001764 neuron migration", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "O08679-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08678-1", "uniprot_id": [ { "id": "MARK1_RAT", "url": "https://www.uniprot.org/uniprot/O08678", "type": "external" } ], "mass": 88235.0, "length": 793, "protein_name": "Serine/threonine-protein kinase MARK1", "gene_name": "Mark1", "organism": "Rat", "refseq_name": "serine/threonine-protein kinase MARK1", "refseq_ac": [ { "id": "NP_446399", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446399", "type": "external" } ], "gene_names_uniprotkb": "Mark1", "gene_names_refseq": "Mark1", "protein_names_uniprotkb": "Serine/threonine-protein kinase MARK1; 2.7.11.1; 2.7.11.26; MAP/microtubule affinity-regulating kinase 1", "protein_names_refseq": "MAP/microtubule affinity-regulating kinase 1; serine/threonine-protein kinase MARK1", "tax_id": 10116, "disease": "visual impairment and progressive phthisis bulbi (Disease Ontology:DOID:0070356); neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (rno:117016)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14517247;14741102;16238695;22673903;25932647;38843836;9108484", "class_list": "", "function": "MARK/Par1 is activated downstream of NMDA receptors in primary hippocampal neurons. Publication Status: Online-Only, [RefSeq, PubMed]; MARK1 was maximally activated between 2 and 5 min after electroconvulsive shock, [RefSeq, PubMed]; Serine/threonine-protein kinase (By similarity). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (By similarity). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3) (PubMed:14517247, PubMed:14741102, PubMed:9108484)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Serine/threonine-protein kinase. Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression;GO:0035556 intracellular signal transduction;GO:0001764 neuron migration", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O08678-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q925Q9-1", "uniprot_id": [ { "id": "SH3K1_RAT", "url": "https://www.uniprot.org/uniprot/Q925Q9", "type": "external" } ], "mass": 78086.0, "length": 709, "protein_name": "SH3 domain-containing kinase-binding protein 1", "gene_name": "Sh3kbp1", "organism": "Rat", "refseq_name": "SH3 domain-containing kinase-binding protein 1", "refseq_ac": [ { "id": "NP_445812", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445812", "type": "external" } ], "gene_names_uniprotkb": "Sh3kbp1; Ruk; Seta", "gene_names_refseq": "CIN85; Seta; Sh3kbp1", "protein_names_uniprotkb": "SH3 domain-containing kinase-binding protein 1; Regulator of ubiquitous kinase; Ruk; SH3-containing, expressed in tumorigenic astrocytes", "protein_names_refseq": "SH3 domain-containing adapter protein; SH3 domain-containing kinase-binding protein 1; SH3-containing, expressed in tumorigenic astrocytes; SH3-domain kinase binding protein 1; regulator of ubiquitous kinase; ruk", "tax_id": 10116, "disease": "immunodeficiency 61 (Disease Ontology:DOID:0111999); nephrotic syndrome (Disease Ontology:DOID:1184); tauopathy (Disease Ontology:DOID:680)", "pathway": " (rno:84357); (R-RNO-182971); (R-RNO-6807004); (R-RNO-8856825); (R-RNO-8856828); (R-RNO-8866376); (R-RNO-983695)", "pathway_count": 7, "publication_count": 8, "publication_id_list": "10921882;11152963;11302255;12135478;12771190;15147912;16751601;22673903", "class_list": "", "function": "Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration (By similarity). Has an essential role in the stimulation of B cell activation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Adaptor protein SETA (CIN85) and its binding partner AIP1 are involved with the cytoskeleton and in the regulation of cell adhesion, [RefSeq, PubMed]; All 3 isoforms of Ruk are ubiquitinated. Specific interaction between the E3 ubiquitin ligase Cbl and all three Ruk isoforms was demonstrated.The interaction of Ruk M and S isoforms with Cbl was found to be mediated via heterodimerization with Ruk L., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q925R0;Q925R1;Q925R2;Q925R3;Q9JKQ0;Q9JKQ1;Q9JLU9", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0030674 protein-macromolecule adaptor activity;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0016477 cell migration;GO:0006915 apoptotic process;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q925Q9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P37285-1", "uniprot_id": [ { "id": "KLC1_RAT", "url": "https://www.uniprot.org/uniprot/P37285", "type": "external" } ], "mass": 63745.0, "length": 560, "protein_name": "Kinesin light chain 1", "gene_name": "Klc1", "organism": "Rat", "refseq_name": "kinesin light chain 1 isoform B", "refseq_ac": [ { "id": "NP_001075442", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075442", "type": "external" } ], "gene_names_uniprotkb": "Klc1; Klc; Kns2", "gene_names_refseq": "Klc1; Kns2", "protein_names_uniprotkb": "Kinesin light chain 1; KLC 1", "protein_names_refseq": "KLC 1; kinesin 2; kinesin light chain 1 isoform B", "tax_id": 10116, "disease": "Alzheimer's disease 1 (Disease Ontology:DOID:0080348); Alzheimer's disease (Disease Ontology:DOID:10652); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378)", "pathway": " (rno:171041); (R-RNO-2132295); (R-RNO-5625970); (R-RNO-6811434); (R-RNO-983189)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "14970196;1946431;19861499;21775604;22673903;29393594", "class_list": "", "function": "Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport (PubMed:19861499). The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (PubMed:19861499)., [UniProtKB, PubMed]; Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019894 kinesin binding;GO:0015631 tubulin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule;GO:0016020 membrane;GO:0030424 axon", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0007155 cell adhesion;GO:0008088 axo-dendritic transport;GO:0007018 microtubule-based movement;GO:0035418 protein localization to synapse", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P37285-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97573-1", "uniprot_id": [ { "id": "SHIP1_RAT", "url": "https://www.uniprot.org/uniprot/P97573", "type": "external" } ], "mass": 133593.0, "length": 1190, "protein_name": "Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1", "gene_name": "Inpp5d", "organism": "Rat", "refseq_name": "phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1", "refseq_ac": [ { "id": "NP_062184", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062184", "type": "external" } ], "gene_names_uniprotkb": "Inpp5d; Ship1; Ship", "gene_names_refseq": "Inpp5d", "protein_names_uniprotkb": "Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1; 3.1.3.36; 3.1.3.56; 3.1.3.86; Inositol polyphosphate-5-phosphatase D; Phosphatidylinositol-4,5-bisphosphate 5-phosphatase; SH2 domain-containing inositol 5'-phosphatase 1; SH2 domain-containing inositol phosphatase 1; SHIP-1", "protein_names_refseq": "Inositol polyphosphate-5-phosphatase, 145 kDa; SH2 domain-containing inositol 5'-phosphatase 1; SH2 domain-containing inositol phosphatase 1; SHIP-1; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1; phosphatidylinositol-4,5-bisphosphate 5-phosphatase", "tax_id": 10116, "disease": "Paget's disease of bone (Disease Ontology:DOID:5408); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (rno:54259); (R-RNO-1660499); (R-RNO-1855204); (R-RNO-202424); (R-RNO-210990); (R-RNO-912526)", "pathway_count": 6, "publication_count": 3, "publication_id_list": "11714805;22673903;8910587", "class_list": "", "function": "Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:8910587). Also, is able to hydrolyze the 5-phosphate of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P3), 1D-myo-inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate (By similarity). Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression (By similarity)., [UniProtKB, PubMed, UniProtKB]; SH2 domain-containing inositol polyphosphate 5'-phosphatase is the primary enzyme responsible for mediating mast cell function-associated antigen (MAFA) inhibition of the Fc epsilon RI stimulus-response-coupling cascade in mast cells., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.95", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.95", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" } ], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0051425 PTB domain binding;GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity;GO:0004445 inositol-polyphosphate 5-phosphatase activity;GO:0052659 inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005884 actin filament;GO:0005886 plasma membrane;GO:0045121 membrane raft", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0035556 intracellular signal transduction;GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0032715 negative regulation of interleukin-6 production", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P97573-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K3Y6-1", "uniprot_id": [ { "id": "ZCCHV_RAT", "url": "https://www.uniprot.org/uniprot/Q8K3Y6", "type": "external" } ], "mass": 86771.0, "length": 776, "protein_name": "Zinc finger CCCH-type antiviral protein 1", "gene_name": "Zc3hav1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Zc3hav1; Zap", "gene_names_refseq": "", "protein_names_uniprotkb": "Zinc finger CCCH-type antiviral protein 1; ADP-ribosyltransferase diphtheria toxin-like 13; ARTD13; Inactive Poly [ADP-ribose] polymerase 13; PARP13; ZAP; Zinc finger antiviral protein; rZAP", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:252832)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "12215647;14557641;15358138;15542630;17182693;17185417;17928353;18225958;18334637;20181706;21204022;21876179;22407013;22514281;22673903", "class_list": "", "function": "Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1) and moloney and murine leukemia virus (MoMLV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0003950 NAD+ poly-ADP-ribosyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0071360 cellular response to exogenous dsRNA;GO:0032727 positive regulation of interferon-alpha production;GO:0050691 regulation of defense response to virus by host;GO:0045087 innate immune response;GO:0051607 defense response to virus", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8K3Y6-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04642-1", "uniprot_id": [ { "id": "LDHA_RAT", "url": "https://www.uniprot.org/uniprot/P04642", "type": "external" } ], "mass": 36451.0, "length": 332, "protein_name": "L-lactate dehydrogenase A chain", "gene_name": "Ldha", "organism": "Rat", "refseq_name": "L-lactate dehydrogenase A chain", "refseq_ac": [ { "id": "NP_058721", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058721", "type": "external" } ], "gene_names_uniprotkb": "Ldha; Ldh-1; Ldh1; Ldhal1", "gene_names_refseq": "CDK1; Ldh1; Ldha", "protein_names_uniprotkb": "L-lactate dehydrogenase A chain; 1.1.1.27; LDH muscle subunit; LDH-A; LDH-M", "protein_names_refseq": "L-lactate dehydrogenase A chain; LDH muscle subunit; LDH-A; LDH-M", "tax_id": 10116, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); hypertension (Disease Ontology:DOID:10763); hyperglycemia (Disease Ontology:DOID:4195)", "pathway": " (rno:24533); (R-RNO-70268); (R-RNO-9861718)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "22673903;29393594;2991914;30171160;32321555;34502162;3873645", "class_list": "", "function": "Arginine is neuroprotective through suppressing HIF-1alpha/LDHA-mediated inflammatory response after cerebral ischemia/reperfusion injury. Publication Status: Online-Only, [RefSeq, PubMed]; Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+)., [UniProtKB, UniProtKB]; LDH-A may be considered as a potential target for alleviating or treating Diabetes-associated Cognitive DeclineDiabetes-associated Cognitive Decline in the future., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.27", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0051287 NAD binding;GO:0019900 kinase binding;GO:0004459 L-lactate dehydrogenase (NAD+) activity;GO:0004457 lactate dehydrogenase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0035686 sperm fibrous sheath;GO:1990204 oxidoreductase complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0001889 liver development;GO:0007584 response to nutrient;GO:0043065 positive regulation of apoptotic process;GO:0001666 response to hypoxia;GO:0042542 response to hydrogen peroxide", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P04642-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17046-1", "uniprot_id": [ { "id": "LAMP2_RAT", "url": "https://www.uniprot.org/uniprot/P17046", "type": "external" } ], "mass": 45156.0, "length": 411, "protein_name": "Lysosome-associated membrane glycoprotein 2", "gene_name": "Lamp2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Lamp2; Lamp-2", "gene_names_refseq": "", "protein_names_uniprotkb": "Lysosome-associated membrane glycoprotein 2; CD107 antigen-like family member B; LAMP-2; LGP-110; LGP-96; LGP-B; Lysosomal membrane glycoprotein type B; Lysosome-associated membrane protein 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "Danon disease (Disease Ontology:DOID:0050437); traumatic brain injury (Disease Ontology:DOID:0081292); sciatic neuropathy (Disease Ontology:DOID:11446); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); cholestasis (Disease Ontology:DOID:13580); cognitive disorder (Disease Ontology:DOID:1561); chronic conjunctivitis (Disease Ontology:DOID:2475); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (rno:24944); (R-RNO-114608); (R-RNO-6798695)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10.1039/D0MO00044B;11082038;1794981;18644871;2142158;24090084;2590192;29393594;34106099;38843836;8662539", "class_list": "", "function": "Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation and autophagy (PubMed:11082038, PubMed:8662539). Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity (By similarity). Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live (PubMed:11082038, PubMed:8662539). Functions by binding target proteins, such as GAPDH, GPX4, NLRP3 and MLLT11, and targeting them for lysosomal degradation (PubMed:11082038, PubMed:18644871, PubMed:8662539). In the chaperone-mediated autophagy, acts downstream of chaperones, such as HSPA8/HSC70, which recognize and bind substrate proteins and mediate their recruitment to lysosomes, where target proteins bind LAMP2 (PubMed:18644871). Plays a role in lysosomal protein degradation in response to starvation (PubMed:11082038). Required for the fusion of autophagosomes with lysosomes during autophagy (By similarity). Cells that lack LAMP2 express normal levels of VAMP8, but fail to accumulate STX17 on autophagosomes, which is the most likely explanation for the lack of fusion between autophagosomes and lysosomes (By similarity). Required for normal degradation of the contents of autophagosomes (By similarity). Required for efficient MHC class II-mediated presentation of exogenous antigens via its function in lysosomal protein degradation; antigenic peptides generated by proteases in the endosomal/lysosomal compartment are captured by nascent MHC II subunits (By similarity). Is not required for efficient MHC class II-mediated presentation of endogenous antigens (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 14, "predicted_n_glycosites": 12, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 8, "disease_count": 8, "glyco_site_count": 17, "binding_glycan_count": 0, "secondary_ac_list": "F1LLX8;Q6P6W1", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0019904 protein domain specific binding;GO:0030674 protein-macromolecule adaptor activity;GO:0035591 signaling adaptor activity;GO:0008200 ion channel inhibitor activity", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005615 extracellular space;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0061684 chaperone-mediated autophagy;GO:0046716 muscle cell cellular homeostasis;GO:0006605 protein targeting;GO:0050821 protein stabilization", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P17046-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1100000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P42335-1", "uniprot_id": [ { "id": "IP3KB_RAT", "url": "https://www.uniprot.org/uniprot/P42335", "type": "external" } ], "mass": 101819.0, "length": 934, "protein_name": "Inositol-trisphosphate 3-kinase B", "gene_name": "Itpkb", "organism": "Rat", "refseq_name": "inositol-trisphosphate 3-kinase B", "refseq_ac": [ { "id": "NP_062185", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062185", "type": "external" } ], "gene_names_uniprotkb": "Itpkb", "gene_names_refseq": "IP3K B; Itpkb", "protein_names_uniprotkb": "Inositol-trisphosphate 3-kinase B; 2.7.1.127; IP3 3-kinase B; IP3K B; Inositol 1,4,5-trisphosphate 3-kinase B; InsP 3-kinase B", "protein_names_refseq": "IP3 3-kinase B; IP3K-B; inositol 1,4,5-trisphosphate 3-kinase B; inositol-trisphosphate 3-kinase B; insP 3-kinase B", "tax_id": 10116, "disease": "autosomal recessive hypophosphatemic rickets (Disease Ontology:DOID:0050949)", "pathway": " (rno:54260); (R-RNO-1855204)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "16173920;22673903;8312366", "class_list": "", "function": "Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis., [UniProtKB, UniProtKB]; The localization and activity of inositol 1,4,5-trisphosphate 3-kinase B(IP3KB) and its modulation by proteolysis are reported., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91XW1", "ec_number_list": [ { "id": "2.7.1.127", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.127", "type": "external" }, { "id": "2.7.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.-.-", "type": "external" } ], "go_molecular_function": "GO:0000828 inositol hexakisphosphate kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:0045061 thymic T cell selection;GO:0046579 positive regulation of Ras protein signal transduction;GO:0007166 cell surface receptor signaling pathway;GO:0000165 MAPK cascade;GO:0071277 cellular response to calcium ion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P42335-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50596-1", "uniprot_id": [ { "id": "LEP_RAT", "url": "https://www.uniprot.org/uniprot/P50596", "type": "external" } ], "mass": 18866.0, "length": 167, "protein_name": "Leptin", "gene_name": "Lep", "organism": "Rat", "refseq_name": "leptin precursor", "refseq_ac": [ { "id": "NP_037208", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037208", "type": "external" } ], "gene_names_uniprotkb": "Lep; Ob", "gene_names_refseq": "Lep; OB; obese", "protein_names_uniprotkb": "Leptin; Obesity factor", "protein_names_refseq": "leptin precursor; obesity factor", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); obstructive sleep apnea (Disease Ontology:DOID:0050848); abdominal obesity-metabolic syndrome (Disease Ontology:DOID:0060611); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); congenital leptin deficiency (Disease Ontology:DOID:0111334); pre-eclampsia (Disease Ontology:DOID:10591); glucose intolerance (Disease Ontology:DOID:10603); short bowel syndrome (Disease Ontology:DOID:10605); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); adult respiratory distress syndrome (Disease Ontology:DOID:11394); osteoporosis (Disease Ontology:DOID:11476); familial hyperlipidemia (Disease Ontology:DOID:1168); gestational diabetes (Disease Ontology:DOID:11714); primary biliary cholangitis (Disease Ontology:DOID:12236); Huntington's disease (Disease Ontology:DOID:12858); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); abdominal obesity-metabolic syndrome 1 (Disease Ontology:DOID:14221); Parkinson's disease (Disease Ontology:DOID:14330); cystic fibrosis (Disease Ontology:DOID:1485); breast cancer (Disease Ontology:DOID:1612); hypogonadism (Disease Ontology:DOID:1924); hyperinsulinism (Disease Ontology:DOID:2018); asthma (Disease Ontology:DOID:2841); acute pancreatitis (Disease Ontology:DOID:2913); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); lipid metabolism disorder (Disease Ontology:DOID:3146); lung non-small cell carcinoma (Disease Ontology:DOID:3908); renal cell carcinoma (Disease Ontology:DOID:4450); rhinitis (Disease Ontology:DOID:4483); hepatocellular clear cell carcinoma (Disease Ontology:DOID:5016); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); osteoarthritis (Disease Ontology:DOID:8398); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25608); (R-RNO-381771); (R-RNO-422085)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "10482243;11460888;11677594;15122202;25232147;34717752;34830465;35806240;37769981;38442503;7657834;7733988;7794258;9003024", "class_list": "", "function": "Baroreflex afferent function is a part of insights of Leptin-mediated blood pressure reduction and Leptin-resistance hypertension., [RefSeq, PubMed]; Breast Milk MicroRNAs Related to Leptin and Adiponectin Function Can Be Modulated by Maternal Diet and Influence Offspring Phenotype in Rats. Publication Status: Online-Only, [RefSeq, PubMed]; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity) (PubMed:11677594). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity (By similarity) (PubMed:10482243, PubMed:11460888, PubMed:11677594, PubMed:9003024). In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides (By similarity) (PubMed:10482243, PubMed:9003024). In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption (By similarity). Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways (By similarity). May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression (By similarity). Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) (PubMed:11460888). In innate immunity, modulates the activity and function of neutrophils by increasing chemotaxis and the secretion of oxygen radicals. Increases phagocytosis by macrophages and enhances secretion of pro-inflammatory mediators. Increases cytotoxic ability of NK cells (Probable). Plays a pro-inflammatory role, in synergy with IL1B, by inducing NOS2 which promotes the production of IL6, IL8 and Prostaglandin E2, through a signaling pathway that involves JAK2, PI3K, MAP2K1/MEK1 and MAPK14/p38 (By similarity). In adaptive immunity, promotes the switch of memory T-cells towards T helper-1 cell immune responses (By similarity). Increases CD4(+)CD25(-) T-cell proliferation and reduces autophagy during TCR (T-cell receptor) stimulation, through MTOR signaling pathway activation and BCL2 up-regulation (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Leptin Induces Apoptotic and Pyroptotic Cell Death via NLRP3 Inflammasome Activation in Rat Hepatocytes. Publication Status: Online-Only, [RefSeq, PubMed]; Leptin decreases the transcription of BKCa channels and Gs to Gi protein-ratio in late pregnant rat uterus., [RefSeq, PubMed]; Synergistic stimulation of osteoblast differentiation of rat mesenchymal stem cells by leptin and 25(OH)D3 is mediated by inhibition of chaperone-mediated autophagy. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 37, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0005102 signaling receptor binding;GO:0005125 cytokine activity;GO:0005179 hormone activity;GO:0051428 peptide hormone receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0010888 negative regulation of lipid storage;GO:2000491 positive regulation of hepatic stellate cell activation;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P50596-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q501L3-1", "uniprot_id": [ { "id": "MSD4_RAT", "url": "https://www.uniprot.org/uniprot/Q501L3", "type": "external" } ], "mass": 41233.0, "length": 345, "protein_name": "Myb/SANT-like DNA-binding domain-containing protein 4", "gene_name": "Msantd4", "organism": "Rat", "refseq_name": "myb/SANT-like DNA-binding domain-containing protein 4", "refseq_ac": [ { "id": "NP_001019528", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019528", "type": "external" } ], "gene_names_uniprotkb": "Msantd4", "gene_names_refseq": "Msantd4", "protein_names_uniprotkb": "Myb/SANT-like DNA-binding domain-containing protein 4", "protein_names_refseq": "Myb/SANT-like DNA-binding domain containing 4 with coiled-coils; myb/SANT-like DNA-binding domain-containing protein 4", "tax_id": 10116, "disease": "", "pathway": " (rno:500941)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q501L3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K5B3-1", "uniprot_id": [ { "id": "MCFD2_RAT", "url": "https://www.uniprot.org/uniprot/Q8K5B3", "type": "external" } ], "mass": 16148.0, "length": 145, "protein_name": "Multiple coagulation factor deficiency protein 2 homolog", "gene_name": "Mcfd2", "organism": "Rat", "refseq_name": "multiple coagulation factor deficiency protein 2 homolog precursor", "refseq_ac": [ { "id": "NP_640346", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_640346", "type": "external" } ], "gene_names_uniprotkb": "Mcfd2; Sdnsf", "gene_names_refseq": "Mcfd2; Sdnsf", "protein_names_uniprotkb": "Multiple coagulation factor deficiency protein 2 homolog; Neural stem cell-derived neuronal survival protein", "protein_names_refseq": "multiple coagulation factor deficiency protein 2 homolog precursor; multiple coagulation factor deficiency protein 2 homolog; neural stem cell-derived neuronal survival protein; stem cell derived neuronal survival protein", "tax_id": 10116, "disease": "transient cerebral ischemia (Disease Ontology:DOID:224)", "pathway": " (rno:246117); (R-RNO-204005); (R-RNO-5694530)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "12832409;17612595;22673903", "class_list": "", "function": "Role as an autocrine/paracrine factor in maintaining stem cell potential and lifelong neurogenesis in adult central nervous system, [RefSeq, PubMed]; SDNSF is expressed in the gray matter of spinal cord. The expression of SDNSF mRNA in the spinal cord varies with injured time. (2) The nestin-positive cells proliferate accompanied with spinal cord injury repair, but do not secrete SDNSF., [RefSeq, PubMed]; The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0062137 cargo receptor complex", "go_biological_process": "GO:0015031 protein transport;GO:0016192 vesicle-mediated transport;GO:0010467 gene expression;GO:0019752 carboxylic acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8K5B3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IMY1-1", "uniprot_id": [ { "id": "MTUS1_RAT", "url": "https://www.uniprot.org/uniprot/Q6IMY1", "type": "external" } ], "mass": 50745.0, "length": 440, "protein_name": "Microtubule-associated tumor suppressor 1 homolog", "gene_name": "Mtus1", "organism": "Rat", "refseq_name": "microtubule-associated tumor suppressor 1 homolog isoform 2", "refseq_ac": [ { "id": "NP_835194", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_835194", "type": "external" } ], "gene_names_uniprotkb": "Mtus1; Atip; Mtsg1", "gene_names_refseq": "ATIP4; Atip3b; Mtsg1; Mtus1", "protein_names_uniprotkb": "Microtubule-associated tumor suppressor 1 homolog; Angiotensin-II type 2 receptor-interacting protein; Mitochondrial tumor suppressor 1 homolog", "protein_names_refseq": "angiotensin-II type 2 receptor-interacting protein; growth factor inhibitor; microtubule associated tumor suppressor 1; microtubule-associated tumor suppressor 1 homolog isoform 2; microtubule-associated tumor suppressor 1 homolog; mitochondrial tumor suppressor 1; transcription factor MTSG1", "tax_id": 10116, "disease": "tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); colon cancer (Disease Ontology:DOID:219); breast carcinoma (Disease Ontology:DOID:3459); ovarian carcinoma (Disease Ontology:DOID:4001); salivary gland adenoid cystic carcinoma (Disease Ontology:DOID:4866); gallbladder carcinoma (Disease Ontology:DOID:4948)", "pathway": " (rno:306487)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17068200;22673903;23559668", "class_list": "", "function": "Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation (By similarity)., [UniProtKB]; This is the first report to identify that ATIP may have a similar role in other disease states characterised by excessive growth, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6XUU5;Q80Z99", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005794 Golgi apparatus", "go_biological_process": "GO:1904385 cellular response to angiotensin;GO:0071375 cellular response to peptide hormone stimulus;GO:0010758 regulation of macrophage chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6IMY1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6TXF5-1", "uniprot_id": [ { "id": "LRC66_RAT", "url": "https://www.uniprot.org/uniprot/Q6TXF5", "type": "external" } ], "mass": 95988.0, "length": 865, "protein_name": "Leucine-rich repeat-containing protein 66", "gene_name": "Lrrc66", "organism": "Rat", "refseq_name": "leucine-rich repeat-containing protein 66", "refseq_ac": [ { "id": "NP_001008763", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008763", "type": "external" } ], "gene_names_uniprotkb": "Lrrc66", "gene_names_refseq": "Lrrc66; RGD1306094", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 66; Liver regeneration-related protein LRRGT00044", "protein_names_refseq": "leucine-rich repeat-containing protein 66-like; leucine-rich repeat-containing protein 66; liver regeneration-related protein LRRGT00044", "tax_id": 10116, "disease": "", "pathway": " (rno:289587)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6TXF5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VIP2-1", "uniprot_id": [ { "id": "MLXPL_RAT", "url": "https://www.uniprot.org/uniprot/Q8VIP2", "type": "external" } ], "mass": 94921.0, "length": 865, "protein_name": "Carbohydrate-responsive element-binding protein", "gene_name": "AABR07035839.1; Mlxipl", "organism": "Rat", "refseq_name": "carbohydrate-responsive element-binding protein isoform 2", "refseq_ac": [ { "id": "NP_598236", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598236", "type": "external" } ], "gene_names_uniprotkb": "AABR07035839.1; Mlxipl; AABR07035839.1; Mlxipl; Wbscr14", "gene_names_refseq": "ChREBP; Mlxipl; WS-bHLH; Wbscr14; bHLHd14", "protein_names_uniprotkb": "Carbohydrate-responsive element-binding protein; ChREBP; Class D basic helix-loop-helix protein 14; MLX interactor; MLX-interacting protein-like; WS basic-helix-loop-helix leucine zipper protein; WS-bHLH; Williams-Beuren syndrome chromosomal region 14 protein; bHLHd14", "protein_names_refseq": "MLX interactor; WS basic-helix-loop-helix leucine zipper protein; Williams-Beuren syndrome chromosomal region 14 protein; Williams-Beuren syndrome chromosome region 14 homolog; carbohydrate-responsive element-binding protein isoform 2; carbohydrate-responsive element-binding protein; class D basic helix-loop-helix protein 14", "tax_id": 10116, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); alcohol use disorder (Disease Ontology:DOID:1574); coronary artery disease (Disease Ontology:DOID:3393); kidney disease (Disease Ontology:DOID:557); myocardial infarction (Disease Ontology:DOID:5844); end stage renal disease (Disease Ontology:DOID:783); type 2 diabetes mellitus (Disease Ontology:DOID:9352); irritable bowel syndrome (Disease Ontology:DOID:9778)", "pathway": " (rno:171078); (R-RNO-163358)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "11698644;11724780;12684532;22673903;24616092;31505737;32518215;38042369;39300600", "class_list": "", "function": "Carbohydrate response element-binding protein (ChREBP) mediates decreased SNAP25 expression in islets from diabetic Goto-Kakizaki (GK) rats., [RefSeq, PubMed]; Glucose-responsive transcription activator that regulates fatty acid synthesis and glycolysis (PubMed:11724780). Key determinant of systemic insulin sensitivity and glucose homeostasis. Important for the expression of fatty acid synthetic enzymes, including PC/Pcx, APOC4/Acl, ACACA/Acc1 and FASN/Fas (By similarity). Important for glucose-induced expression of L-type pyruvate kinase/PKLR (PubMed:11724780). Binds to the canonical and non-canonical E box DNA sequences 5'-CACGTG-3' and 5'-CACGCG-3' (By similarity). May also act as a transcriptional repressor (By similarity)., [UniProtKB, PubMed, UniProtKB]; These findings suggest FMK may protect against HG-induced beta-cell dysfunction and TXNIP expression by ChREBP regulation in pancreatic beta-cells, and that FMK is a potential therapeutic reagent for the drug development of diabetes and its complications. Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptional activation of the Myc gene by glucose in beta-cells requires a ChREBP-dependent 3-D chromatin interaction between the Myc and Pvt1 genes., [RefSeq, PubMed]; Upregulation of Mlxipl induced by cJun in the spinal dorsal horn after peripheral nerve injury counteracts mechanical allodynia by inhibiting neuroinflammation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0019901 protein kinase binding;GO:0046982 protein heterodimerization activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006110 regulation of glycolytic process;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007584 response to nutrient", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8VIP2-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ER30-1", "uniprot_id": [ { "id": "KLH41_RAT", "url": "https://www.uniprot.org/uniprot/Q9ER30", "type": "external" } ], "mass": 68213.0, "length": 606, "protein_name": "Kelch-like protein 41", "gene_name": "Klhl41", "organism": "Rat", "refseq_name": "kelch-like protein 41", "refseq_ac": [ { "id": "NP_476539", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476539", "type": "external" } ], "gene_names_uniprotkb": "Klhl41; Kbtbd10; Krp1", "gene_names_refseq": "Kbtbd10; Klhl41; Krp1; Sarcosin", "protein_names_uniprotkb": "Kelch-like protein 41; Kel-like protein 23; Kelch repeat and BTB domain-containing protein 10; Kelch-related protein 1; Sarcosin", "protein_names_refseq": "kel-like protein 23; kelch repeat and BTB (POZ) domain containing 10; kelch repeat and BTB domain-containing protein 10; kelch-like 41; kelch-like protein 41; kelch-related protein 1; sarcomeric muscle protein", "tax_id": 10116, "disease": "nemaline myopathy 9 (Disease Ontology:DOID:0110929); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); nemaline myopathy (Disease Ontology:DOID:3191)", "pathway": " (rno:117537); (R-RNO-8951664); (R-RNO-983168)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10713668;12692149;16449658;19726686;21368295;22673903", "class_list": "", "function": "Binding sites necessary for Krp1-Lasp1 interaction in vitro and function in vivo., [RefSeq, PubMed]; Data show that both knockdown and overexpression of Krp1 inhibit myoblast differentiation assessed by expression of myogenin, MEF2C, MHC, and cell fusion., [RefSeq, PubMed]; Involved in skeletal muscle development and differentiation. Regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. Required for pseudopod elongation in transformed cells., [UniProtKB, UniProtKB, PubMed]; Krp1, the AP-1 up-regulated protein that has a role in pseudopodial elongation in v-Fos-transformed fibroblast cells, forms a novel interaction with the nondifferentially expressed actin binding protein Lasp-1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005789 endoplasmic reticulum membrane;GO:0031143 pseudopodium", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0035914 skeletal muscle cell differentiation;GO:2000291 regulation of myoblast proliferation;GO:0030239 myofibril assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9ER30-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1P3-1", "uniprot_id": [ { "id": "MCL1_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z1P3", "type": "external" } ], "mass": 35214.0, "length": 330, "protein_name": "Induced myeloid leukemia cell differentiation protein Mcl-1 homolog", "gene_name": "Mcl1", "organism": "Rat", "refseq_name": "induced myeloid leukemia cell differentiation protein Mcl-1 homolog", "refseq_ac": [ { "id": "NP_068618", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068618", "type": "external" } ], "gene_names_uniprotkb": "Mcl1", "gene_names_refseq": "Mcl1", "protein_names_uniprotkb": "Induced myeloid leukemia cell differentiation protein Mcl-1 homolog", "protein_names_refseq": "BCL2 family apoptosis regulator; MCL1, BCL2 family apoptosis regulator; induced myeloid leukemia cell differentiation protein Mcl-1 homolog; myeloid cell leukemia 1; myeloid cell leukemia sequence 1", "tax_id": 10116, "disease": "stomach cancer (Disease Ontology:DOID:10534); lung cancer (Disease Ontology:DOID:1324); colon cancer (Disease Ontology:DOID:219); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:60430)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10579309;29393594;33378038;36260529;39160285", "class_list": "", "function": "Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis., [UniProtKB]; Long noncoding RNA XIST regulates cardiomyocyte apoptosis by targeting miR-873-5p/MCL1 axis., [RefSeq, PubMed]; N6-methyladenosine modification in trophoblasts promotes circSETD2 expression, inhibits miR-181a-5p, and elevates MCL1 transcription to reduce apoptosis of trophoblasts., [RefSeq, PubMed]; Regulatory axis of circular RNA DTNB, microRNA-485-5p, and myeloid cell leukemia 1 attenuates inflammation and apoptosis in caerulein-treated AR42J cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6AYY5;Q9R289", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0046983 protein dimerization activity;GO:0015267 channel activity;GO:0044877 protein-containing complex binding;GO:0051434 BH3 domain binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0030154 cell differentiation;GO:0043065 positive regulation of apoptotic process;GO:0043066 negative regulation of apoptotic process;GO:0006974 DNA damage response;GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9Z1P3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62915-1", "uniprot_id": [ { "id": "CSKP_RAT", "url": "https://www.uniprot.org/uniprot/Q62915", "type": "external" } ], "mass": 103259.0, "length": 909, "protein_name": "Peripheral plasma membrane protein CASK", "gene_name": "Cask", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cask", "gene_names_refseq": "", "protein_names_uniprotkb": "Peripheral plasma membrane protein CASK; 2.7.11.1; Calcium/calmodulin-dependent serine protein kinase", "protein_names_refseq": "", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); syndromic X-linked intellectual disability (Disease Ontology:DOID:0060309); syndromic X-linked intellectual disability Najm type (Disease Ontology:DOID:0060807); FG syndrome (Disease Ontology:DOID:14711)", "pathway": " (rno:29647); (R-RNO-212676); (R-RNO-6794361)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10749215;11865057;12040031;12151521;12641734;14627983;15048107;15994232;25385611;8786425;9753324", "class_list": "", "function": "Multidomain scaffolding Mg(2+)-independent protein kinase that catalyzes the phosphotransfer from ATP to proteins such as NRXN1, and plays a role in synaptic transmembrane protein anchoring and ion channel trafficking (By similarity). Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking.ontributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins, and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005102 signaling receptor binding;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0005080 protein kinase C binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0032024 positive regulation of insulin secretion;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0072659 protein localization to plasma membrane;GO:0021987 cerebral cortex development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q62915-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47727-1", "uniprot_id": [ { "id": "CBR1_RAT", "url": "https://www.uniprot.org/uniprot/P47727", "type": "external" } ], "mass": 30578.0, "length": 277, "protein_name": "Carbonyl reductase [NADPH] 1", "gene_name": "Cbr1l1; Cbr1l2; Cbr1l3; Cbr1", "organism": "Rat", "refseq_name": "carbonyl reductase [NADPH] 1", "refseq_ac": [ { "id": "NP_062043", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062043", "type": "external" } ], "gene_names_uniprotkb": "Cbr1l1; Cbr1l2; Cbr1l3; Cbr1; Cbr1l1; Cbr1l3; Cbr1; Cbr; LOC100360601; LOC102556347", "gene_names_refseq": "Cbr1; Cbr; PG-9-KR", "protein_names_uniprotkb": "Carbonyl reductase [NADPH] 1; 1.1.1.184; 1.1.1.189; 1.1.1.196; 1.1.1.197; 1.1.1.71; 15-hydroxyprostaglandin dehydrogenase [NADP(+)]; 20-beta-hydroxysteroid dehydrogenase; Alcohol dehydrogenase [NAD(P)+] CBR1; NADPH-dependent carbonyl reductase 1; PG-9-KR; Prostaglandin 9-ketoreductase; Prostaglandin-E(2) 9-reductase", "protein_names_refseq": "15-hydroxyprostaglandin dehydrogenase; 20-beta-hydroxysteroid dehydrogenase; NADPH-dependent carbonyl reductase 1; alcohol dehydrogenase [NAD(P)+] CBR1; carbonyl reductase [NADPH] 1; prostaglandin 9-ketoreductase; prostaglandin-E(2) 9-reductase", "tax_id": 10116, "disease": "chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (rno:120093083); (rno:29224); (R-RNO-2162123)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "22673903;7705364;8198567;9015353", "class_list": "", "function": "NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics (PubMed:7705364, PubMed:8198567). Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol (By similarity). Can convert prostaglandin E to prostaglandin F2-alpha (By similarity). Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione. In addition, participates in the glucocorticoid metabolism by catalyzing the NADPH-dependent cortisol/corticosterone into 20beta-dihydrocortisol (20b-DHF) or 20beta-corticosterone (20b-DHB), which are weak agonists of NR3C1 and NR3C2 in adipose tissue (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O08558;Q3KR58", "ec_number_list": [ { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "1.1.1.122", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.122", "type": "external" }, { "id": "1.6.5.10", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.10", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "1.1.1.104", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.104", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.2", "type": "external" }, { "id": "1.1.1.189", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.189", "type": "external" }, { "id": "1.1.1.197", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.197", "type": "external" }, { "id": "1.1.1.196", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.196", "type": "external" }, { "id": "1.1.1.71", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.71", "type": "external" }, { "id": "1.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.-.-", "type": "external" }, { "id": "1.1.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.19", "type": "external" }, { "id": "1.1.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.20", "type": "external" }, { "id": "1.1.1.372", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.372", "type": "external" }, { "id": "1.1.1.54", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.54", "type": "external" } ], "go_molecular_function": "GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor;GO:0047020 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity;GO:0004090 carbonyl reductase (NADPH) activity;GO:0047021 15-hydroxyprostaglandin dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005902 microvillus;GO:0005737 cytoplasm", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0032496 response to lipopolysaccharide;GO:0006805 xenobiotic metabolic process;GO:0032570 response to progesterone;GO:1905344 prostaglandin catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P47727-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88871-1", "uniprot_id": [ { "id": "GABR2_RAT", "url": "https://www.uniprot.org/uniprot/O88871", "type": "external" } ], "mass": 105751.0, "length": 940, "protein_name": "Gamma-aminobutyric acid type B receptor subunit 2", "gene_name": "Gabbr2", "organism": "Rat", "refseq_name": "gamma-aminobutyric acid type B receptor subunit 2 precursor", "refseq_ac": [ { "id": "NP_113990", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113990", "type": "external" } ], "gene_names_uniprotkb": "Gabbr2; Gpr51", "gene_names_refseq": "Gabbr2; Gpr51", "protein_names_uniprotkb": "Gamma-aminobutyric acid type B receptor subunit 2; G protein-coupled receptor 51; GABA-B receptor 2; GABA-B-R2; GABA-BR2; GABABR2; Gb2", "protein_names_refseq": "G-protein coupled receptor 51; GABA-B R2 receptor; GABA-B receptor 2; GABA-B-R2; GABA-BR2; GABABR2; gamma-aminobutyric acid (GABA) B receptor 2; gamma-aminobutyric acid type B receptor subunit 2 precursor; gb2", "tax_id": 10116, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); developmental and epileptic encephalopathy 59 (Disease Ontology:DOID:0080291); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (rno:83633); (R-RNO-1296041); (R-RNO-418594); (R-RNO-420499); (R-RNO-977444); (R-RNO-997272)", "pathway_count": 6, "publication_count": 20, "publication_id_list": "10.1039/D0MO00044B;10075644;10457184;10658574;10727622;10924501;14718537;20400944;22673903;24020808;24090084;24425870;27515806;31678999;34106099;34680170;38843836;9872315;9872317;9872744", "class_list": "", "function": "Component of a heterodimeric G protein-coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:9872315, PubMed:9872317, PubMed:9872744). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed:10658574, PubMed:9872317). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:10075644, PubMed:10924501, PubMed:9872315, PubMed:9872317, PubMed:9872744, Ref.4). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed:10457184, PubMed:10924501, PubMed:9872315, PubMed:9872317, PubMed:9872744). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (PubMed:10457184, PubMed:9872317, PubMed:9872744). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed:10924501, PubMed:9872744). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Gabbr2 exists in rat brain at birth and decreases between birth and PD15., [RefSeq, PubMed]; Natural Product Isoliquiritigenin Activates GABAB Receptors to Decrease Voltage-Gate Ca(2+) Channels and Glutamate Release in Rat Cerebrocortical Nerve Terminals. Publication Status: Online-Only, [RefSeq, PubMed]; Study provided evidence that GABAB2 subunit is involved in anxiety-like behaviours induced by chronic cerebral hypoperfusion. Activation of GABAB2 subunits could improve BDNF/TrkB/NCAM signalling and reverse Kir3 channel surface expressions in hippocampal CA1, which may alleviate the anxiety-like behaviours in rats with chronic cerebral hypoperfusion., [RefSeq, PubMed]; This study shows that the trafficking and surface expression of GABABR2 and GABABR1 is differentially regulated by synaptic or pathophysiological activation of NMDA receptors., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 7, "disease_count": 3, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q9JK36;Q9QWU2", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0004965 G protein-coupled GABA receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007214 gamma-aminobutyric acid signaling pathway;GO:0051932 synaptic transmission, GABAergic;GO:0150099 neuron-glial cell signaling", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "O88871-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70587-1", "uniprot_id": [ { "id": "LRRC7_RAT", "url": "https://www.uniprot.org/uniprot/P70587", "type": "external" } ], "mass": 166879.0, "length": 1490, "protein_name": "Leucine-rich repeat-containing protein 7", "gene_name": "Lrrc7", "organism": "Rat", "refseq_name": "leucine-rich repeat-containing protein 7 isoform 2", "refseq_ac": [ { "id": "NP_476483", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476483", "type": "external" } ], "gene_names_uniprotkb": "Lrrc7; Lap1", "gene_names_refseq": "Lrrc7", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 7; Densin-180; Densin; Protein LAP1", "protein_names_refseq": "densin 13T-16; densin 13T-17; densin 13T-23; densin 13T-29; densin 13T-41; densin 13T-43; densin 13T-57C; densin 13T-57; densin 13T-72; densin 13T-89; densin-180; leucine-rich repeat-containing protein 7 isoform 2; leucine-rich repeat-containing protein 7", "tax_id": 10116, "disease": "cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (rno:117284); (R-RNO-438066); (R-RNO-5673001); (R-RNO-6798695)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "10827168;12390249;21610080;22673903;23516094;30325965;8824323", "class_list": "", "function": "Adapter protein that is required for correct postsynapse architecture and regulates postsynaptic plasticity through interactions with different partners (By similarity). Through its interaction with CACNA1C, it enhances trafficking of voltage-dependent L-type calcium channels to the dendritic cell membrane and increases channel postsynaptic clustering, thereby facilitating excitatory calcium signaling (By similarity). It also serves as a scaffold that brings CAMK2A and PPP1CA into close proximity, probably facilitating rapid dephosphorylation of CAMK2A by PPP1CA and influencing CAMK2A-mediated regulation of postsynaptic plasticity (By similarity). Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term synaptic depression (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Analysis of densin at the ultrastructural level reveals potential sites that can support specific interactions of densin. Densin molecules firmly embedded within the postsynaptic densities (PSD) may target a minor pool of CaMKII to substrates at the PSD core Publication Status: Online-Only, [RefSeq, PubMed]; Characterization of a central Ca2+/calmodulin-dependent protein kinase IIalpha/beta binding domain in densin that selectively modulates glutamate receptor subunit phosphorylation., [RefSeq, PubMed]; Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Topology of densin involves the membrane association configuration, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JI42", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0005912 adherens junction;GO:0014069 postsynaptic density;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane;GO:0010976 positive regulation of neuron projection development;GO:0098609 cell-cell adhesion;GO:0043113 receptor clustering;GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P70587-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97829-1", "uniprot_id": [ { "id": "CD47_RAT", "url": "https://www.uniprot.org/uniprot/P97829", "type": "external" } ], "mass": 32995.0, "length": 303, "protein_name": "Leukocyte surface antigen CD47", "gene_name": "Cd47", "organism": "Rat", "refseq_name": "leukocyte surface antigen CD47 precursor", "refseq_ac": [ { "id": "NP_062068", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062068", "type": "external" } ], "gene_names_uniprotkb": "Cd47", "gene_names_refseq": "Cd47; Itgp", "protein_names_uniprotkb": "Leukocyte surface antigen CD47; IAP; Integrin-associated protein", "protein_names_refseq": "CD47 antigen (Rh-related antigen, integrin-associated signal transducer); IAP; integrin-associated protein; leukocyte surface antigen CD47 precursor; leukocyte surface antigen CD47", "tax_id": 10116, "disease": "", "pathway": " (rno:29364); (R-RNO-202733); (R-RNO-216083); (R-RNO-391160); (R-RNO-6798695)", "pathway_count": 5, "publication_count": 13, "publication_id_list": "10.1039/D0MO00044B;21454685;22673903;24090084;31059044;31377653;33945877;34106099;36528876;38279488;38843836;9119739;9592107", "class_list": "", "function": "Adhesive protein that mediates cell-to-cell interactions. Acts as a receptor for thrombospondin THBS1 and as modulator of integrin signaling through the activation of heterotrimeric G proteins. Involved in signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, cellular self-renewal, and immunoregulation. Plays a role in modulating pulmonary endothelin EDN1 signaling (By similarity). Modulates nitrous oxide (NO) signaling, in response to THBS1, hence playing a role as a pressor agent, supporting blood pressure (By similarity). Plays an important role in memory formation and synaptic plasticity in the hippocampus (PubMed:9592107). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation (By similarity). Positively modulates FAS-dependent apoptosis in T-cells, perhaps by enhancing FAS clustering (By similarity). Plays a role in suppressing angiogenesis and may be involved in metabolic dysregulation during normal aging (By similarity). In response to THBS1, negatively modulates wound healing. Inhibits stem cell self-renewal, in response to THBS1, probably by regulation of the stem cell transcription factors POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 (By similarity). May play a role in membrane transport and/or integrin dependent signal transduction (By similarity). May prevent premature elimination of red blood cells (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Anti-tumor effect of PTEN and its effect on inhibition of the bone tumor through the CD47-SIRPalpha signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; CD47 blocking antibody accelerates hematoma clearance and alleviates hydrocephalus after experimental intraventricular hemorrhage., [RefSeq, PubMed]; For the quantification of an anti-CD47 monoclonal antibody., [RefSeq, PubMed]; The CD47 antibody or SiCD47 can protect cardiomyocytes against H/R injury through increasing autophagic flux and autophagic clearance. CD47 deficiency may offer a potential therapeutic approach for preventing myocardial I/R injury., [RefSeq, PubMed]; Upregulated TSP1 and CD47 expression in the lung in nitrofen-induced congenital diaphragmatic hernia., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 4, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 25, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "O35294", "ec_number_list": [], "go_molecular_function": "GO:0070053 thrombospondin receptor activity;GO:0098632 cell-cell adhesion mediator activity;GO:0086080 protein binding involved in heterotypic cell-cell adhesion;GO:0070051 fibrinogen binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0070062 extracellular exosome;GO:0098793 presynapse", "go_biological_process": "GO:0022409 positive regulation of cell-cell adhesion;GO:0060368 regulation of Fc receptor mediated stimulatory signaling pathway;GO:0006954 inflammatory response;GO:0007229 integrin-mediated signaling pathway;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 4.3, "record_id": "P97829-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11275-1", "uniprot_id": [ { "id": "KCC2A_RAT", "url": "https://www.uniprot.org/uniprot/P11275", "type": "external" } ], "mass": 54115.0, "length": 478, "protein_name": "Calcium/calmodulin-dependent protein kinase type II subunit alpha", "gene_name": "Camk2a", "organism": "Rat", "refseq_name": "calcium/calmodulin-dependent protein kinase type II subunit alpha", "refseq_ac": [ { "id": "NP_037052", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037052", "type": "external" } ], "gene_names_uniprotkb": "Camk2a", "gene_names_refseq": "Camk2a; PK2CDD; PKCCD", "protein_names_uniprotkb": "Calcium/calmodulin-dependent protein kinase type II subunit alpha; 2.7.11.17; CaM kinase II subunit alpha; CaMK-II subunit alpha", "protein_names_refseq": "Ca2+/calmodulin-dependent protein kinase II alpha; alpha CaM kinase II; caM kinase II subunit alpha; caM-kinase II alpha chain; caMK-II subunit alpha; calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha; calcium/calmodulin-dependent protein kinase II alpha subunit; calcium/calmodulin-dependent protein kinase type II alpha chain; calcium/calmodulin-dependent protein kinase type II subunit alpha", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); mitochondrial complex IV deficiency nuclear type 23 (Disease Ontology:DOID:0070485); autosomal dominant intellectual developmental disorder 53 (Disease Ontology:DOID:0080228); autosomal recessive intellectual developmental disorder 63 (Disease Ontology:DOID:0081224); heart conduction disease (Disease Ontology:DOID:10273); Alzheimer's disease (Disease Ontology:DOID:10652); transient cerebral ischemia (Disease Ontology:DOID:224); high grade glioma (Disease Ontology:DOID:3070); bipolar disorder (Disease Ontology:DOID:3312); middle cerebral artery infarction (Disease Ontology:DOID:3525)", "pathway": " (rno:25400); (R-RNO-3371571); (R-RNO-399719); (R-RNO-4086398); (R-RNO-438066); (R-RNO-5578775); (R-RNO-5673000); (R-RNO-5673001); (R-RNO-877300); (R-RNO-936837)", "pathway_count": 10, "publication_count": 25, "publication_id_list": "11182241;11972023;1328883;15312654;15659234;17923693;18372251;1849884;18683930;2153289;22673903;23687301;24591565;2842767;2856087;28772011;29808487;3037704;3475713;34775982;36424866;38199412;38843836;8384482;9724800", "class_list": "", "function": "Avoidance memory requires CaMKII activity to persist after recall. Publication Status: Online-Only, [RefSeq, PubMed]; Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (PubMed:15312654). Regulates dendritic spine development. Also regulates the migration of developing neurons. Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (By similarity). Phosphorylates the transcription factor ETS1 in response to calcium signaling, thereby decreasing ETS1 affinity for DNA (By similarity). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (PubMed:11972023). In response to interferon-beta (IFN-beta) stimulation, stimulates the JAK-STAT signaling pathway (By similarity). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of PSAT1, inhibiting ferroptosis by promoting GPX4 hydroxylation and stability (By similarity). Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB]; Maternal deprivation causes CaMKII downregulation and modulates glutamate, norepinephrine and serotonin in limbic brain areas in a rat model of single prolonged stress., [RefSeq, PubMed]; Receptor-interacting protein 3-phosphorylated Ca[2+] /calmodulin-dependent protein kinase II and mixed lineage kinase domain-like protein mediate intracerebral hemorrhage-induced neuronal necroptosis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "7.2.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.10", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0014069 postsynaptic density", "go_biological_process": "GO:0002931 response to ischemia;GO:0006468 protein phosphorylation;GO:0035235 ionotropic glutamate receptor signaling pathway;GO:0006816 calcium ion transport;GO:2000124 regulation of endocannabinoid signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P11275-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63092-1", "uniprot_id": [ { "id": "CAMKV_RAT", "url": "https://www.uniprot.org/uniprot/Q63092", "type": "external" } ], "mass": 54106.0, "length": 504, "protein_name": "CaM kinase-like vesicle-associated protein", "gene_name": "Camkv", "organism": "Rat", "refseq_name": "caM kinase-like vesicle-associated protein", "refseq_ac": [ { "id": "NP_076490", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076490", "type": "external" } ], "gene_names_uniprotkb": "Camkv; 1G5", "gene_names_refseq": "1G5; Camkv", "protein_names_uniprotkb": "CaM kinase-like vesicle-associated protein; 1G5", "protein_names_refseq": "caM kinase-like vesicle-associated protein; vesicle-associated calmodulin-binding protein", "tax_id": 10116, "disease": "", "pathway": " (rno:79011)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "18683930;22673903;27796283;38843836;8283228", "class_list": "", "function": "Camkv has a role in activity-dependent maintenance of dendritic spines Publication Status: Online-Only, [RefSeq, PubMed]; Has no detectable kinase activity in vitro., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0004683 calcium/calmodulin-dependent protein kinase activity;GO:0004672 protein kinase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0045202 synapse;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0050804 modulation of chemical synaptic transmission;GO:0099159 regulation of modification of postsynaptic structure", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q63092-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V8I2-1", "uniprot_id": [ { "id": "CNDH2_RAT", "url": "https://www.uniprot.org/uniprot/Q4V8I2", "type": "external" } ], "mass": 62637.0, "length": 554, "protein_name": "Condensin-2 complex subunit H2", "gene_name": "Ncaph2", "organism": "Rat", "refseq_name": "condensin-2 complex subunit H2 isoform 2", "refseq_ac": [ { "id": "NP_001020048", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020048", "type": "external" } ], "gene_names_uniprotkb": "Ncaph2", "gene_names_refseq": "Ncaph2", "protein_names_uniprotkb": "Condensin-2 complex subunit H2; Non-SMC condensin II complex subunit H2", "protein_names_refseq": "condensin-2 complex subunit H2 isoform 2; condensin-2 complex subunit H2", "tax_id": 10116, "disease": "", "pathway": " (rno:300149); (R-RNO-2299718)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (By similarity). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (By similarity). Seems to have lineage-specific role in T-cell development (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000793 condensed chromosome;GO:0005694 chromosome", "go_biological_process": "GO:1905820 positive regulation of chromosome separation;GO:0051984 positive regulation of chromosome segregation;GO:0021987 cerebral cortex development;GO:0007076 mitotic chromosome condensation;GO:0007143 female meiotic nuclear division", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4V8I2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66HD5-1", "uniprot_id": [ { "id": "CLIP4_RAT", "url": "https://www.uniprot.org/uniprot/Q66HD5", "type": "external" } ], "mass": 64645.0, "length": 599, "protein_name": "CAP-Gly domain-containing linker protein 4", "gene_name": "Clip4", "organism": "Rat", "refseq_name": "CAP-Gly domain-containing linker protein 4 isoform 2", "refseq_ac": [ { "id": "NP_001013964", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013964", "type": "external" } ], "gene_names_uniprotkb": "Clip4; Rsnl2", "gene_names_refseq": "Clip4; RGD1311049; Rsnl2", "protein_names_uniprotkb": "CAP-Gly domain-containing linker protein 4; Restin-like protein 2", "protein_names_refseq": "CAP-Gly domain-containing linker protein 4 isoform 2; CAP-Gly domain-containing linker protein 4; restin-like 2; restin-like protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:298801)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q66HD5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88267-1", "uniprot_id": [ { "id": "ACOT1_RAT", "url": "https://www.uniprot.org/uniprot/O88267", "type": "external" } ], "mass": 46013.0, "length": 419, "protein_name": "Acyl-coenzyme A thioesterase 1", "gene_name": "Acot1", "organism": "Rat", "refseq_name": "acyl-coenzyme A thioesterase 1", "refseq_ac": [ { "id": "NP_112605", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112605", "type": "external" } ], "gene_names_uniprotkb": "Acot1; Cte1", "gene_names_refseq": "Acot1; Cte1", "protein_names_uniprotkb": "Acyl-coenzyme A thioesterase 1; 3.1.2.-; 3.1.2.2; ACH2; Acyl-CoA thioesterase 1; CTE-I; Inducible cytosolic acyl-coenzyme A thioester hydrolase; LACH2; Long chain acyl-CoA hydrolase; Long chain acyl-CoA thioester hydrolase; Palmitoyl-coenzyme A thioesterase", "protein_names_refseq": "ACH2; CTE-I; LACH2; acyl-CoA thioesterase 1, cytosolic; acyl-coenzyme A thioesterase 1; cytosolic acyl-CoA thioesterase 1; inducible cytosolic acyl-coenzyme A thioester hydrolase; long chain acyl-CoA hydrolase; long chain acyl-CoA thioester hydrolase; palmitoyl-coenzyme A thioesterase", "tax_id": 10116, "disease": "", "pathway": " (rno:50559); (R-RNO-77289); (R-RNO-9033241); (R-RNO-9837999)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "21094633;22673903;23226270;23385637;7906114;9445388;9490035;9703974", "class_list": "", "function": "ACOT isoform expression may be regulated during brown adipocyte differentiation to support the fat storage and combustion characteristics of this cell type., [RefSeq, PubMed]; ACOT1 plays a crucial protective role in the diabetic heart via PPARalpha/PGC1alpha signaling., [RefSeq, PubMed]; Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. More active towards saturated and unsaturated long chain fatty acyl-CoAs (C12-C20)., [UniProtKB, PubMed]; The Acot1 expression is transiently upregulated at an early stage of adipocyte maturation, possibly to maintain cytosolic acyl-CoAs below a certain level until the cells acquire their full capability for fat storage., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O55161", "ec_number_list": [ { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "1.2.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "1.4.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1", "type": "external" }, { "id": "3.5.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.6", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" }, { "id": "3.1.2.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.14", "type": "external" }, { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "5.1.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "4.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.9", "type": "external" }, { "id": "1.1.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.41", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" } ], "go_molecular_function": "GO:0047617 fatty acyl-CoA hydrolase activity;GO:0052689 carboxylic ester hydrolase activity;GO:0016790 thiolester hydrolase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0000038 very long-chain fatty acid metabolic process;GO:0001676 long-chain fatty acid metabolic process;GO:0006631 fatty acid metabolic process;GO:0006637 acyl-CoA metabolic process;GO:0010667 negative regulation of cardiac muscle cell apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O88267-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P98158-1", "uniprot_id": [ { "id": "LRP2_RAT", "url": "https://www.uniprot.org/uniprot/P98158", "type": "external" } ], "mass": 519276.0, "length": 4660, "protein_name": "Low-density lipoprotein receptor-related protein 2", "gene_name": "Lrp2", "organism": "Rat", "refseq_name": "low-density lipoprotein receptor-related protein 2 precursor", "refseq_ac": [ { "id": "NP_110454", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_110454", "type": "external" } ], "gene_names_uniprotkb": "Lrp2", "gene_names_refseq": "Lrp2", "protein_names_uniprotkb": "Low-density lipoprotein receptor-related protein 2; Glycoprotein 330; LRP-2; Megalin; gp330", "protein_names_refseq": "LRP-2; glycoprotein 330; gp330; low density lipoprotein-related protein 2; low-density lipoprotein receptor-related protein 2 precursor; low-density lipoprotein receptor-related protein 2; megalin", "tax_id": 10116, "disease": "Donnai-Barrow syndrome (Disease Ontology:DOID:0090144); Fanconi syndrome (Disease Ontology:DOID:1062); hypertension (Disease Ontology:DOID:10763); membranous glomerulonephritis (Disease Ontology:DOID:10976); degenerative myopia (Disease Ontology:DOID:11829); myopia (Disease Ontology:DOID:11830); congenital heart disease (Disease Ontology:DOID:1682); nephrosis (Disease Ontology:DOID:2527); autoimmune thyroiditis (Disease Ontology:DOID:7188); end stage renal disease (Disease Ontology:DOID:783); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898)", "pathway": " (rno:29216); (R-RNO-196791); (R-RNO-8856825); (R-RNO-8856828); (R-RNO-975634); (R-RNO-9758890)", "pathway_count": 6, "publication_count": 31, "publication_id_list": "10704528;11964399;12519751;12724130;1400426;15126248;15467006;16099815;16143106;16380466;16801528;17063000;17245526;17324488;17462596;17846082;18466341;19202329;22649097;22673903;23836931;28659595;29949391;29954945;32200675;36922642;37702891;6752952;7510321;7544804;7937880", "class_list": "", "function": "Angiotensin II type 2 receptor activation preserves megalin in the kidney and prevents proteinuria in high salt diet fed rats. Publication Status: Online-Only, [RefSeq, PubMed]; Low Density Lipoprotein Receptor-related Protein 2 Expression and Function in Cultured Astrocytes and Microglia., [RefSeq, PubMed]; Megalin: A Novel Endocytic Receptor for Prorenin and Renin., [RefSeq, PubMed]; Multiligand endocytic receptor. Acts together with CUBN to mediate endocytosis of high-density lipoproteins (By similarity). Mediates receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B (PubMed:19202329, PubMed:7544804). In the kidney, mediates the tubular uptake and clearance of leptin (By similarity). Also mediates transport of leptin across the blood-brain barrier through endocytosis at the choroid plexus epithelium (PubMed:17324488). Endocytosis of leptin in neuronal cells is required for hypothalamic leptin signaling and leptin-mediated regulation of feeding and body weight (By similarity). Mediates endocytosis and subsequent lysosomal degradation of CST3 in kidney proximal tubule cells (PubMed:17462596). Mediates renal uptake of 25-hydroxyvitamin D3 in complex with the vitamin D3 transporter GC/DBP (By similarity). Mediates renal uptake of metallothionein-bound heavy metals (PubMed:15126248). Together with CUBN, mediates renal reabsorption of myoglobin (PubMed:12724130). Mediates renal uptake and subsequent lysosomal degradation of APOM (PubMed:16099815). Plays a role in kidney selenium homeostasis by mediating renal endocytosis of selenoprotein SEPP1 (By similarity). Mediates renal uptake of the antiapoptotic protein BIRC5/survivin which may be important for functional integrity of the kidney (By similarity). Mediates renal uptake of matrix metalloproteinase MMP2 in complex with metalloproteinase inhibitor TIMP1 (PubMed:28659595). Mediates endocytosis of Sonic hedgehog protein N-product (ShhN), the active product of SHH (PubMed:11964399, PubMed:16801528). Also mediates ShhN transcytosis (PubMed:16801528). In the embryonic neuroepithelium, mediates endocytic uptake and degradation of BMP4, is required for correct SHH localization in the ventral neural tube and plays a role in patterning of the ventral telencephalon (By similarity). Required at the onset of neurulation to sequester SHH on the apical surface of neuroepithelial cells of the rostral diencephalon ventral midline and to control PTCH1-dependent uptake and intracellular trafficking of SHH (By similarity). During neurulation, required in neuroepithelial cells for uptake of folate bound to the folate receptor FOLR1 which is necessary for neural tube closure (By similarity). In the adult brain, negatively regulates BMP signaling in the subependymal zone which enables neurogenesis to proceed (By similarity). In astrocytes, mediates endocytosis of ALB which is required for the synthesis of the neurotrophic factor oleic acid (PubMed:18466341). Involved in neurite branching (By similarity). During optic nerve development, required for SHH-mediated migration and proliferation of oligodendrocyte precursor cells (By similarity). Mediates endocytic uptake and clearance of SHH in the retinal margin which protects retinal progenitor cells from mitogenic stimuli and keeps them quiescent (By similarity). Plays a role in reproductive organ development by mediating uptake in reproductive tissues of androgen and estrogen bound to the sex hormone binding protein SHBG (PubMed:16143106). Mediates endocytosis of angiotensin-2 (PubMed:15467006). Also mediates endocytosis of angiotensin 1-7 (PubMed:16380466). Binds to the complex composed of beta-amyloid protein 40 and CLU/APOJ and mediates its endocytosis and lysosomal degradation (By similarity). Required for embryonic heart development (By similarity). Required for normal hearing, possibly through interaction with estrogen in the inner ear (PubMed:17846082)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Renal megalin expression was found to be upregulated in early type 2 diabetic rats in a process that may involve high glucose and insulin in a PI3K/Akt-dependent manner., [RefSeq, PubMed]", "predicted_glycosites": 23, "predicted_n_glycosites": 22, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 20, "reported_o_glycosites": 12, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 8, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 21, "total_reported_o_glycosites": 13, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 21, "total_o_glycosites": 13, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 9, "reported_phosphosites": 6, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 50, "disease_count": 11, "glyco_site_count": 55, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0050750 low-density lipoprotein particle receptor binding;GO:0051087 protein-folding chaperone binding;GO:0005509 calcium ion binding;GO:0042562 hormone binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0006766 vitamin metabolic process;GO:1904888 cranial skeletal system development;GO:1905167 positive regulation of lysosomal protein catabolic process;GO:0072237 metanephric proximal tubule development;GO:0006897 endocytosis", "synthesized_glycan_count": 0, "hit_score": 11.6, "record_id": "P98158-1", "record_type": "protein", "filter_code": "0000000.0100111.000100.000000000000001000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1H228-1", "uniprot_id": [ { "id": "ODAD1_RAT", "url": "https://www.uniprot.org/uniprot/B1H228", "type": "external" } ], "mass": 78170.0, "length": 694, "protein_name": "Outer dynein arm-docking complex subunit 1", "gene_name": "Odad1", "organism": "Rat", "refseq_name": "outer dynein arm-docking complex subunit 1", "refseq_ac": [ { "id": "NP_001119749", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119749", "type": "external" } ], "gene_names_uniprotkb": "Odad1; Ccdc114", "gene_names_refseq": "Ccdc114; Odad1; RGD1308141", "protein_names_uniprotkb": "Outer dynein arm-docking complex subunit 1; Coiled-coil domain-containing protein 114", "protein_names_refseq": "coiled-coil domain containing 114; coiled-coil domain-containing protein 114; outer dynein arm-docking complex subunit 1", "tax_id": 10116, "disease": "primary ciliary dyskinesia 20 (Disease Ontology:DOID:0110625)", "pathway": " (rno:308594)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Component of the outer dynein arm-docking complex that mediates outer dynein arms (ODA) binding onto the doublet microtubule. Involved in mediating assembly of both ODAs and their axonemal docking complex onto ciliary microtubules (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005929 cilium;GO:0005930 axoneme;GO:0036157 outer dynein arm;GO:0120228 outer dynein arm docking complex", "go_biological_process": "GO:0003341 cilium movement;GO:0036158 outer dynein arm assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B1H228-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62871-1", "uniprot_id": [ { "id": "DC1I2_RAT", "url": "https://www.uniprot.org/uniprot/Q62871", "type": "external" } ], "mass": 71178.0, "length": 638, "protein_name": "Cytoplasmic dynein 1 intermediate chain 2", "gene_name": "Dync1i2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Dync1i2; Dnci2; Dncic2", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytoplasmic dynein 1 intermediate chain 2; Cytoplasmic dynein intermediate chain 2; DH IC-2; Dynein intermediate chain 2, cytosolic", "protein_names_refseq": "", "tax_id": 10116, "disease": "autosomal recessive primary microcephaly (Disease Ontology:DOID:0070296)", "pathway": " (rno:116659); (R-RNO-141430); (R-RNO-141444); (R-RNO-2132295); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-2565942); (R-RNO-3371497); (R-RNO-380259); (R-RNO-380270); (R-RNO-380284); (R-RNO-380320); (R-RNO-5620912); (R-RNO-5663220); (R-RNO-6807878); (R-RNO-6811436); (R-RNO-68877); (R-RNO-8854518); (R-RNO-9646399); (R-RNO-9648025)", "pathway_count": 20, "publication_count": 9, "publication_id_list": "10893223;11340075;17279546;17965411;22673903;27502274;8522607;8688562;9790665", "class_list": "", "function": "Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function (PubMed:11340075). Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (PubMed:11340075). The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1 (PubMed:11340075). Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes (PubMed:11340075)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q62872;Q62873", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0045503 dynein light chain binding;GO:0045504 dynein heavy chain binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005874 microtubule;GO:0031982 vesicle;GO:0005868 cytoplasmic dynein complex;GO:0036157 outer dynein arm", "go_biological_process": "GO:1990090 cellular response to nerve growth factor stimulus;GO:0010977 negative regulation of neuron projection development;GO:0007018 microtubule-based movement;GO:0010970 transport along microtubule", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q62871-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19491-1", "uniprot_id": [ { "id": "GRIA2_RAT", "url": "https://www.uniprot.org/uniprot/P19491", "type": "external" } ], "mass": 98688.0, "length": 883, "protein_name": "Glutamate receptor 2", "gene_name": "Gria2", "organism": "Rat", "refseq_name": "glutamate receptor 2 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001077280", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077280", "type": "external" } ], "gene_names_uniprotkb": "Gria2; GluA2; Glur2", "gene_names_refseq": "GluA2; GluR-K2; GluR2; Gria2; gluR-B", "protein_names_uniprotkb": "Glutamate receptor 2; AMPA-selective glutamate receptor 2; GluR-2; GluR-B; GluR-K2; Glutamate receptor ionotropic, AMPA 2", "protein_names_refseq": "AMPA-selective glutamate receptor 2; glutamate receptor 2 isoform 2 precursor; glutamate receptor B; glutamate receptor, ionotropic, AMPA 2", "tax_id": 10116, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); status epilepticus (Disease Ontology:DOID:1824); morphine dependence (Disease Ontology:DOID:2560); central nervous system disease (Disease Ontology:DOID:331); amphetamine abuse (Disease Ontology:DOID:670); cannabis abuse (Disease Ontology:DOID:9505); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:29627); (R-RNO-399710); (R-RNO-416993); (R-RNO-438066)", "pathway_count": 4, "publication_count": 64, "publication_id_list": "10027300;10414981;11086992;11773314;12015593;12215417;12501192;12593667;12657670;12730367;12872125;14687553;15240807;15591246;16037816;16192394;16483599;1653450;16630835;16793768;1699275;1699567;17018279;1717158;18817736;19234459;19265014;19908285;19946266;20547133;20802490;21172611;21317873;21496646;2166337;2168579;21846932;23212166;23986250;24231469;24381264;24966661;25103405;25689263;26098845;27756895;29107806;29134962;29422059;29432883;30584244;32729828;33244735;33919872;34252589;35136046;35969153;37704721;38843836;8848293;9069286;9351977;9697855;9804426", "class_list": "", "function": "AMPA Receptor Expression Requirement During Long-Term Memory Retrieval and Its Association with mTORC1 Signaling., [RefSeq, PubMed]; Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, Gria1-4. The subunit encoded by this gene (Gria2) is subject to RNA editing (Q/R and R/G), which is thought to render the channels impermeable to Ca(2+), and to affect the kinetic aspects of these channels in rat brain. Alternative splicing, resulting in transcript variants encoding different isoforms (flip and flop), has been noted for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]; Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid (PubMed:12015593, PubMed:12730367, PubMed:15591246, PubMed:2166337, PubMed:21846932, PubMed:9351977). L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system and plays an important role in fast excitatory synaptic transmission (By similarity). Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse upon entry of monovalent and divalent cations such as sodium and calcium (PubMed:11773314, PubMed:12501192, PubMed:12730367, PubMed:12872125, PubMed:16483599, PubMed:1653450, PubMed:17018279, PubMed:19946266). The receptor then desensitizes rapidly and enters in a transient inactive state, characterized by the presence of bound agonist (PubMed:12015593, PubMed:16192394, PubMed:17018279, PubMed:19946266). In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of L-glutamate (PubMed:21172611). Through complex formation with NSG1, GRIP1 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (PubMed:16037816)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Mechanisms underlying TARP modulation of the GluA1/2-gamma8 AMPA receptor. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The application of the self-probing primer PCR for quantitative expression analysis of R607Q (un)edited GluA2 AMPA receptor mRNA., [RefSeq, PubMed]; The dorsal hippocampal CA3 regulates spatial reference memory through the CtBP2/GluR2 pathway., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9R174", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0022849 glutamate-gated calcium ion channel activity;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0001540 amyloid-beta binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0008328 ionotropic glutamate receptor complex;GO:0048787 presynaptic active zone membrane;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "GO:1900452 regulation of long-term synaptic depression;GO:1990416 cellular response to brain-derived neurotrophic factor stimulus;GO:0031623 receptor internalization;GO:0035235 ionotropic glutamate receptor signaling pathway;GO:0051262 protein tetramerization", "synthesized_glycan_count": 0, "hit_score": 6.9, "record_id": "P19491-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64060-1", "uniprot_id": [ { "id": "DDX4_RAT", "url": "https://www.uniprot.org/uniprot/Q64060", "type": "external" } ], "mass": 77955.0, "length": 713, "protein_name": "Probable ATP-dependent RNA helicase DDX4", "gene_name": "Ddx4", "organism": "Rat", "refseq_name": "probable ATP-dependent RNA helicase DDX4", "refseq_ac": [ { "id": "NP_001071115", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071115", "type": "external" } ], "gene_names_uniprotkb": "Ddx4", "gene_names_refseq": "Ddx4; RVLG", "protein_names_uniprotkb": "Probable ATP-dependent RNA helicase DDX4; 3.6.4.13; DEAD box protein 4; Vasa homolog; rVLG", "protein_names_refseq": "DEAD (Asp-Glu-Ala-Asp) box polypeptide 4; DEAD box protein 4; probable ATP-dependent RNA helicase DDX4; putative ATP-dependent RNA helicase DDX4; vasa homolog; vasa-like gene protein", "tax_id": 10116, "disease": "", "pathway": " (rno:310090); (R-RNO-9696264)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "22673903;32020412;7857296", "class_list": "", "function": "ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process, the production of piRNAs in fetal male germ cells through a ping-pong amplification cycle. Required for PIWIL2 slicing-triggered piRNA biogenesis: helicase activity enables utilization of one of the slice cleavage fragments generated by PIWIL2 and processing these pre-piRNAs into piRNAs., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The protective effect of platelet-rich plasma administrated on ovarian function in female rats with Cy-induced ovarian damage., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.3.2", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.17.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.22", "type": "external" } ], "go_molecular_function": "GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity;GO:0140693 molecular condensate scaffold activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:1990904 ribonucleoprotein complex;GO:0071546 pi-body", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0030317 flagellated sperm motility;GO:0032526 response to retinoic acid;GO:0032880 regulation of protein localization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q64060-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97571-1", "uniprot_id": [ { "id": "CAN1_RAT", "url": "https://www.uniprot.org/uniprot/P97571", "type": "external" } ], "mass": 82119.0, "length": 713, "protein_name": "Calpain-1 catalytic subunit", "gene_name": "Capn1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Capn1; Cls1", "gene_names_refseq": "", "protein_names_uniprotkb": "Calpain-1 catalytic subunit; 3.4.22.52; CANP 1; Calcium-activated neutral proteinase 1; Calpain mu-type; Calpain-1 large subunit; Micromolar-calpain; muCANP", "protein_names_refseq": "", "tax_id": 10116, "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545); ciliopathy (Disease Ontology:DOID:0060340); mitochondrial complex IV deficiency nuclear type 20 (Disease Ontology:DOID:0070505); traumatic brain injury (Disease Ontology:DOID:0081292); hereditary spastic paraplegia 76 (Disease Ontology:DOID:0110821); aortic atherosclerosis (Disease Ontology:DOID:10230); intellectual disability (Disease Ontology:DOID:1059); Alzheimer's disease (Disease Ontology:DOID:10652); sciatic neuropathy (Disease Ontology:DOID:11446); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); epilepsy (Disease Ontology:DOID:1826); hereditary spastic paraplegia (Disease Ontology:DOID:2476); acute kidney failure (Disease Ontology:DOID:3021); cytochrome-c oxidase deficiency disease (Disease Ontology:DOID:3762); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:29153); (R-RNO-1474228); (R-RNO-6798695)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "11893336;14656436;15491615;29393594;8950173", "class_list": "", "function": "Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves CTBP1 at 'Asn-364', 'Gly-377' and 'His-399'. Cleaves and activates caspase-7 (CASP7)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": 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"type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.4.22.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.53", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" } ], "go_molecular_function": "GO:0004198 calcium-dependent cysteine-type endopeptidase activity;GO:0019899 enzyme binding;GO:0005509 calcium ion binding;GO:0008092 cytoskeletal protein binding;GO:0008233 peptidase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0046685 response to arsenic-containing substance;GO:1903238 positive regulation of leukocyte tethering or rolling;GO:0006508 proteolysis;GO:0050790 regulation of catalytic activity;GO:0070301 cellular response to hydrogen peroxide", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P97571-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63448-1", "uniprot_id": [ { "id": "ACOX3_RAT", "url": "https://www.uniprot.org/uniprot/Q63448", "type": "external" } ], "mass": 78446.0, "length": 700, "protein_name": "Peroxisomal acyl-coenzyme A oxidase 3", "gene_name": "Acox3", "organism": "Rat", "refseq_name": "peroxisomal acyl-coenzyme A oxidase 3", "refseq_ac": [ { "id": "NP_445791", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445791", "type": "external" } ], "gene_names_uniprotkb": "Acox3; Prcox", "gene_names_refseq": "Acox3", "protein_names_uniprotkb": "Peroxisomal acyl-coenzyme A oxidase 3; 1.3.3.6; BRCACox; Branched-chain acyl-CoA oxidase; Pristanoyl-CoA oxidase", "protein_names_refseq": "BRCACox; acyl-Coenzyme A oxidase 3, pristanoyl; branched-chain acyl-CoA oxidase; peroxisomal acyl-coenzyme A oxidase 3; pristanoyl-CoA oxidase", "tax_id": 10116, "disease": "", "pathway": " (rno:83522); (R-RNO-389887); (R-RNO-9033241)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "1400324;22673903;8706733", "class_list": "", "function": "Involved in peroxisomal beta-oxidation of branched-chain fatty acids (BCFAs). Catalyzes the initial and rate-limiting dehydrogenation step that removes two hydrogen molecules and introduces a trans double bond between the alpha and beta carbons of the acyl CoA molecules while generating hydrogen peroxide as a by-product (Probable). Metabolizes multi-methyl-branched fatty acyl-CoA esters such as (2S)-pristanoyl-CoA, displaying redundancy with ACOX3 (Probable). Can oxidize straight-chain mono- and dicarboxylyl fatty acyl-CoAs with lower efficiency (Probable)., [UniProtKB, PubMed, PubMed]; Oxidizes the CoA-esters of 2-methyl-branched fatty acids., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "1.2.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "1.4.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" }, { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "5.1.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "4.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.9", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" } ], "go_molecular_function": "GO:0005504 fatty acid binding;GO:0050660 flavin adenine dinucleotide binding;GO:0071949 FAD binding;GO:0016402 pristanoyl-CoA oxidase activity;GO:0120524 long-chain fatty acyl-CoA oxidase activity", "go_cellular_component": "GO:0005777 peroxisome", "go_biological_process": "GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q63448-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q920G2-1", "uniprot_id": [ { "id": "NHRF2_RAT", "url": "https://www.uniprot.org/uniprot/Q920G2", "type": "external" } ], "mass": 37369.0, "length": 337, "protein_name": "Na(+)/H(+) exchange regulatory cofactor NHE-RF2", "gene_name": "Nherf2", "organism": "Rat", "refseq_name": "Na(+)/H(+) exchange regulatory cofactor NHE-RF2", "refseq_ac": [ { "id": "NP_446263", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446263", "type": "external" } ], "gene_names_uniprotkb": "Nherf2; Slc9a3r2", "gene_names_refseq": "E3karp; Nherf2; Slc9a3r2", "protein_names_uniprotkb": "Na(+)/H(+) exchange regulatory cofactor NHE-RF2; NHE3 kinase A regulatory protein E3KARP; NHERF-2; SIP-1; SRY-interacting protein 1; Sodium-hydrogen exchanger regulatory factor 2; Solute carrier family 9 isoform A3 regulatory factor 2; TKA-1; Tyrosine kinase activator protein 1", "protein_names_refseq": "NHE3 kinase A regulatory protein E3KARP; NHERF-2; Na(+)/H(+) exchange regulatory cofactor NHE-RF2; SIP-1; SLC9A3 regulator 2; SRY-interacting protein 1; TKA-1; sodium-hydrogen exchanger regulatory factor 2; solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2; solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2; tyrosine kinase activator protein 1", "tax_id": 10116, "disease": "hypophosphatemic nephrolithiasis/osteoporosis 2 (Disease Ontology:DOID:0080078); hypertension (Disease Ontology:DOID:10763)", "pathway": " (rno:116501)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11124833;11457882;22673903;23612977;28669731", "class_list": "", "function": "NHERF2 domain was functionally significant in NHE3 regulation, being necessary for stimulation by lysophosphatidic acid of activity and increased mobility of NHE3, [RefSeq, PubMed]; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; The results suggest that NHERF1 and NHERF2 down-regulated SR-B1 at least in part via the ubiquitin/proteasome pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91Y70", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0050750 low-density lipoprotein particle receptor binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0012505 endomembrane system;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0007605 sensory perception of sound;GO:0034767 positive regulation of monoatomic ion transmembrane transport;GO:0048839 inner ear development;GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q920G2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08837-1", "uniprot_id": [ { "id": "CDC5L_RAT", "url": "https://www.uniprot.org/uniprot/O08837", "type": "external" } ], "mass": 92218.0, "length": 802, "protein_name": "Cell division cycle 5-like protein", "gene_name": "Cdc5l", "organism": "Rat", "refseq_name": "cell division cycle 5-like protein", "refseq_ac": [ { "id": "NP_445979", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445979", "type": "external" } ], "gene_names_uniprotkb": "Cdc5l; Pcdc5rp", "gene_names_refseq": "Cdc5l", "protein_names_uniprotkb": "Cell division cycle 5-like protein; Cdc5-like protein; Pombe Cdc5-related protein", "protein_names_refseq": "CDC5 cell division cycle 5-like; cdc5-like protein; cell division cycle 5-like protein; cell division cycle 5-related protein; pombe Cdc5-related protein", "tax_id": 10116, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); osteosarcoma (Disease Ontology:DOID:3347); esophagus adenocarcinoma (Disease Ontology:DOID:4914)", "pathway": " (rno:85434); (R-RNO-72163)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10827081;11694351;11884640;16352598;22673903", "class_list": "", "function": "DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0043522 leucine zipper domain binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:1990090 cellular response to nerve growth factor stimulus", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O08837-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08482-1", "uniprot_id": [ { "id": "ACM1_RAT", "url": "https://www.uniprot.org/uniprot/P08482", "type": "external" } ], "mass": 51369.0, "length": 460, "protein_name": "Muscarinic acetylcholine receptor M1", "gene_name": "Chrm1", "organism": "Rat", "refseq_name": "muscarinic acetylcholine receptor M1", "refseq_ac": [ { "id": "NP_542951", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_542951", "type": "external" } ], "gene_names_uniprotkb": "Chrm1; Chrm-1", "gene_names_refseq": "Chrm1", "protein_names_uniprotkb": "Muscarinic acetylcholine receptor M1", "protein_names_refseq": "Cholinergic receptor, muscarin 1; m1 muscarinic acetylcholine receptor protein; muscarinic acetylcholine receptor M1", "tax_id": 10116, "disease": "Lambert-Eaton myasthenic syndrome (Disease Ontology:DOID:0050214); neurodegeneration with brain iron accumulation (Disease Ontology:DOID:0110734); asthma (Disease Ontology:DOID:2841); myasthenia gravis (Disease Ontology:DOID:437)", "pathway": " (rno:25229); (R-RNO-390648); (R-RNO-416476)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "1317867;1759615;22673903;2380182;27569857;29030298;29705702;3037705;31721013;32798726", "class_list": "", "function": "PKC and Ras are Involved in M1 Muscarinic Receptor-Mediated Modulation of AMPA Receptor GluA1 Subunit., [RefSeq, PubMed]; PKC delta activation modulates neurotrophins levels by a signaling pathway that involves M1R activation and ultimately leading to an increase in retinal ganglion cells survival in vitro., [RefSeq, PubMed]; Results establish an intracellular pathway linking M1 receptors, inositol triphosphate receptors, and ubiquitin proteasome system activity to object memory destabilization and suggest a previously unacknowledged role for cholinergic signaling in long-term memory modification and storage., [RefSeq, PubMed]; Striatal and nigral muscarinic type 1 and type 4 receptors modulate levodopa-induced dyskinesia and striato-nigral pathway activation in 6-hydroxydopamine hemilesioned rats., [RefSeq, PubMed]; Study examined the expression of M1 muscarinic ACh receptors in the hippocampus at 7 and 30 days following experimental bilateral vestibular lesions (BVL) in rats using autoradiography. Analysis of the brain tissue revealed a significant reduction in the number of M1 receptors throughout the hippocampus and striatum at 30 days but not at 7 days following BVL., [RefSeq, PubMed]; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016907 G protein-coupled acetylcholine receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0032279 asymmetric synapse;GO:0043679 axon terminus", "go_biological_process": "GO:0007197 adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway;GO:0007213 G protein-coupled acetylcholine receptor signaling pathway;GO:0007274 neuromuscular synaptic transmission;GO:0040012 regulation of locomotion;GO:0043270 positive regulation of monoatomic ion transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P08482-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10860-1", "uniprot_id": [ { "id": "DHE3_RAT", "url": "https://www.uniprot.org/uniprot/P10860", "type": "external" } ], "mass": 61416.0, "length": 558, "protein_name": "Glutamate dehydrogenase 1, mitochondrial", "gene_name": "Glud1", "organism": "Rat", "refseq_name": "glutamate dehydrogenase 1, mitochondrial precursor", "refseq_ac": [ { "id": "NP_036702", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036702", "type": "external" } ], "gene_names_uniprotkb": "Glud1; Glud", "gene_names_refseq": "Ac2-281; Gdh1; Glud1; Gludeha; Glud; MRG-2", "protein_names_uniprotkb": "Glutamate dehydrogenase 1, mitochondrial; 1.4.1.3; GDH 1; MRG-2; Memory-related gene 2 protein", "protein_names_refseq": "glutamate dehydrogenase 1, mitochondrial precursor; glutamate dehydrogenase 1, mitochondrial; memory-related gene 2 protein", "tax_id": 10116, "disease": "familial hyperinsulinemic hypoglycemia 6 (Disease Ontology:DOID:0070217); Alzheimer's disease (Disease Ontology:DOID:10652); hepatic encephalopathy (Disease Ontology:DOID:13413); childhood absence epilepsy (Disease Ontology:DOID:1825); hyperinsulinism (Disease Ontology:DOID:2018); brain ischemia (Disease Ontology:DOID:2316); temporal lobe epilepsy (Disease Ontology:DOID:3328); fascioliasis (Disease Ontology:DOID:885); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (rno:24399); (R-RNO-2151201); (R-RNO-8964539); (R-RNO-9837999)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "1684101;18683930;22673903;24319738;26446791;2704624;2704625;27213235;29784783;35904584;8094669;9275181", "class_list": "", "function": "Findings demonstrate that hippocampal synapse assembly and maintenance require a tripartite molecular complex in which the ligand Cbln2 binds with presynaptic neurexin 1beta (+S4) and postsynaptic GluD1., [RefSeq, PubMed]; GDH promotes isoprenaline-induced cardiac hypertrophy by activating mTOR signaling via elevation of alpha-ketoglutarate level., [RefSeq, PubMed]; Glutamate dehydrogenase is differentially regulated in liver and muscle of rats with transplanted Guerin's carcinoma., [RefSeq, PubMed]; Mitochondrial glutamate dehydrogenase that converts L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (By similarity). Plays a role in insulin homeostasis (By similarity). May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (PubMed:9275181)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q66HI8;Q6LC16", "ec_number_list": [ { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "6.2.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.1", "type": "external" }, { "id": "6.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.17", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "1.15.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.15.1.1", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0019899 enzyme binding;GO:0042803 protein homodimerization activity;GO:0043531 ADP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0032024 positive regulation of insulin secretion;GO:0010044 response to aluminum ion;GO:0007616 long-term memory;GO:0006541 glutamine metabolic process;GO:0021549 cerebellum development", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P10860-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15087-1", "uniprot_id": [ { "id": "CBPE_RAT", "url": "https://www.uniprot.org/uniprot/P15087", "type": "external" } ], "mass": 53309.0, "length": 476, "protein_name": "Carboxypeptidase E", "gene_name": "Cpe", "organism": "Rat", "refseq_name": "carboxypeptidase E precursor", "refseq_ac": [ { "id": "NP_037260", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037260", "type": "external" } ], "gene_names_uniprotkb": "Cpe", "gene_names_refseq": "CARBE; Cpe; Cph", "protein_names_uniprotkb": "Carboxypeptidase E; 3.4.17.10; CPE; CPH; Carboxypeptidase H; Enkephalin convertase; Prohormone-processing carboxypeptidase", "protein_names_refseq": "carboxypeptidase E precursor; carboxypeptidase H; enkephalin convertase; prohormone-processing carboxypeptidase", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); age related macular degeneration 1 (Disease Ontology:DOID:0110014); cataract 10 multiple types (Disease Ontology:DOID:0110258); microphthalmia (Disease Ontology:DOID:10629); morbid obesity (Disease Ontology:DOID:11981); atherosclerosis (Disease Ontology:DOID:1936); glioblastoma (Disease Ontology:DOID:3068); coronary artery disease (Disease Ontology:DOID:3393); retinal detachment (Disease Ontology:DOID:5327); cataract (Disease Ontology:DOID:83); ocular hypertension (Disease Ontology:DOID:9282); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25669)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "14597614;15240697;1770952;1955501;2334405;24090084;2725530;2784437;34266900", "class_list": "", "function": "Carboxypeptidase E Regulates Activity-Dependent TrkB Neuronal Surface Insertion and Hippocampal Memory., [RefSeq, PubMed]; Sorting receptor that directs prohormones to the regulated secretory pathway. Also acts as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 4, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 10, "disease_count": 14, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019904 protein domain specific binding;GO:0004180 carboxypeptidase activity;GO:0050839 cell adhesion molecule binding;GO:0004181 metallocarboxypeptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005794 Golgi apparatus;GO:0030141 secretory granule", "go_biological_process": "GO:0016485 protein processing;GO:0016486 peptide hormone processing;GO:0001764 neuron migration;GO:0043171 peptide catabolic process;GO:0070301 cellular response to hydrogen peroxide", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P15087-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19633-1", "uniprot_id": [ { "id": "CASQ1_RAT", "url": "https://www.uniprot.org/uniprot/P19633", "type": "external" } ], "mass": 46449.0, "length": 406, "protein_name": "Calsequestrin-1", "gene_name": "Casq1", "organism": "Rat", "refseq_name": "calsequestrin-1 precursor", "refseq_ac": [ { "id": "NP_001153066", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153066", "type": "external" } ], "gene_names_uniprotkb": "Casq1", "gene_names_refseq": "Casq1", "protein_names_uniprotkb": "Calsequestrin-1; Aspartactin; Calsequestrin, skeletal muscle isoform; Laminin-binding protein", "protein_names_refseq": "Aspartactin; Calsequestrin-1; Laminin-binding protein; calsequestrin 1 (fast-twitch, skeletal muscle); calsequestrin-1 precursor", "tax_id": 10116, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:686019); (R-RNO-2672351); (R-RNO-5578775)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "22673903;25084748;3417768;37589058;8042990", "class_list": "", "function": "Acute aerobic exercise regulation of myocardial calcium homeostasis involves CASQ1, CASQ2, and TRDN., [RefSeq, PubMed]; CSQ-1 expression in platelets is gradually downregulated as diabetes progresses, causing a progressive disruption of internal Ca2+ store recycling, and platelet function., [RefSeq, PubMed]; Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle (PubMed:8042990). Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction (By similarity). Negatively regulates store-operated Ca(2+) entry (SOCE) activity (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005759 mitochondrial matrix;GO:0005783 endoplasmic reticulum;GO:0031674 I band;GO:0042383 sarcolemma;GO:0030018 Z disc", "go_biological_process": "GO:0014870 response to muscle inactivity;GO:1901341 positive regulation of store-operated calcium channel activity;GO:0051281 positive regulation of release of sequestered calcium ion into cytosol;GO:0014894 response to denervation involved in regulation of muscle adaptation;GO:0045214 sarcomere organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P19633-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20272-1", "uniprot_id": [ { "id": "CNR1_RAT", "url": "https://www.uniprot.org/uniprot/P20272", "type": "external" } ], "mass": 52845.0, "length": 473, "protein_name": "Cannabinoid receptor 1", "gene_name": "Cnr1", "organism": "Rat", "refseq_name": "cannabinoid receptor 1", "refseq_ac": [ { "id": "NP_036916", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036916", "type": "external" } ], "gene_names_uniprotkb": "Cnr1; Skr6", "gene_names_refseq": "CB-R; CB1R; CB1; Cnr1; SKR6R", "protein_names_uniprotkb": "Cannabinoid receptor 1; Brain-type cannabinoid receptor; CB-R; CB1", "protein_names_refseq": "Cannabinoid CB1 receptor; brain-type cannabinoid receptor; cannabinoid receptor 1 (brain); cannabinoid receptor 1", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); Parkinsonism (Disease Ontology:DOID:0080855); hypertension (Disease Ontology:DOID:10763); alcohol use disorder (Disease Ontology:DOID:1574); status epilepticus (Disease Ontology:DOID:1824); impotence (Disease Ontology:DOID:1875); focal epilepsy (Disease Ontology:DOID:2234); schizophrenia (Disease Ontology:DOID:5419); peptic ulcer disease (Disease Ontology:DOID:750); type 2 diabetes mellitus (Disease Ontology:DOID:9352); cannabis abuse (Disease Ontology:DOID:9505); diabetic neuropathy (Disease Ontology:DOID:9743); obesity (Disease Ontology:DOID:9970); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:25248); (R-RNO-373076); (R-RNO-418594)", "pathway_count": 3, "publication_count": 20, "publication_id_list": "10234009;10362691;10891614;16033894;17895407;18077343;2165569;21895628;23955712;26671069;33582301;35908495;36270348;37085778;38368587;38780511;38843836;7876112;8832654;9526000", "class_list": "", "function": "Activation of CB1R alleviates central sensitization by regulating HCN2-pNR2B signaling in a chronic migraine rat model. Publication Status: Online-Only, [RefSeq, PubMed]; Comparative assessment of CacyBP/SIP, beta-catenin and cannabinoid receptors in the adrenals of hypertensive rats., [RefSeq, PubMed]; Dominance status is associated with a variation in cannabinoid receptor 1 expression and amphetamine reward., [RefSeq, PubMed]; Fatty Acid Amide Hydrolase and Cannabinoid Receptor Type 1 Genes Regulation is Modulated by Social Isolation in Rats., [RefSeq, PubMed]; G protein-coupled receptor for cannabinoids, including endocannabinoids (eCBs), such as N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG) (PubMed:2165569). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while decreases respiration at high doses. At high doses, CNR1 signal transduction involves G protein alpha-i protein activation and subsequent inhibition of mitochondrial soluble adenylate cyclase, decrease in cyclic AMP concentration, inhibition of protein kinase A (PKA)-dependent phosphorylation of specific subunits of the mitochondrial electron transport system, including NDUFS2. In the hypothalamus, inhibits leptin-induced reactive oxygen species (ROS) formation and mediates cannabinoid-induced increase in SREBF1 and FASN gene expression. In response to cannabinoids, drives the release of orexigenic beta-endorphin, but not that of melanocyte-stimulating hormone alpha/alpha-MSH, from hypothalamic POMC neurons, hence promoting food intake. In the hippocampus, regulates cellular respiration and energy production in response to cannabinoids. Involved in cannabinoid-dependent depolarization-induced suppression of inhibition (DSI), a process in which depolarization of CA1 postsynaptic pyramidal neurons mobilizes eCBs, which retrogradely activate presynaptic CB1 receptors, transiently decreasing GABAergic inhibitory neurotransmission. Also reduces excitatory synaptic transmission (By similarity). In superior cervical ganglions and cerebral vascular smooth muscle cells, inhibits voltage-gated Ca(2+) channels in a constitutive, as well as agonist-dependent manner (By similarity). Induces leptin production in adipocytes and reduces LRP2-mediated leptin clearance in the kidney, hence participating in hyperleptinemia. In adipose tissue, CNR1 signaling leads to increased expression of SREBF1, ACACA and FASN genes. In the liver, activation by endocannabinoids leads to increased de novo lipogenesis and reduced fatty acid catabolism, associated with increased expression of SREBF1/SREBP-1, GCK, ACACA, ACACB and FASN genes. May also affect de novo cholesterol synthesis and HDL-cholesteryl ether uptake (By similarity). Peripherally modulates energy metabolism. In high carbohydrate diet-induced obesity, may decrease the expression of mitochondrial dihydrolipoyl dehydrogenase/DLD in striated muscles, as well as that of selected glucose/ pyruvate metabolic enzymes, hence affecting energy expenditure through mitochondrial metabolism (PubMed:26671069). In response to cannabinoid anandamide, elicits a pro-inflammatory response in macrophages, which involves NLRP3 inflammasome activation and IL1B and IL18 secretion. In macrophages infiltrating pancreatic islets, this process may participate in the progression of type-2 diabetes and associated loss of pancreatic beta-cells (PubMed:23955712)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Inulin may prevent steatosis by suppressing cannabinoid receptor-1 and patatin-like phospholipase-3 expression in liver., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 15, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0042802 identical protein binding;GO:0004949 cannabinoid receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:1900452 regulation of long-term synaptic depression;GO:0098921 retrograde trans-synaptic signaling by endocannabinoid;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P20272-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21571-1", "uniprot_id": [ { "id": "ATP5J_RAT", "url": "https://www.uniprot.org/uniprot/P21571", "type": "external" } ], "mass": 12494.0, "length": 108, "protein_name": "ATP synthase peripheral stalk subunit F6, mitochondrial", "gene_name": "Atp5pf", "organism": "Rat", "refseq_name": "ATP synthase peripheral stalk subunit F6, mitochondrial", "refseq_ac": [ { "id": "NP_446054", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446054", "type": "external" } ], "gene_names_uniprotkb": "Atp5pf; Atp5j", "gene_names_refseq": "Atp5j; Atp5pf", "protein_names_uniprotkb": "ATP synthase peripheral stalk subunit F6, mitochondrial; ATP synthase peripheral stalk subunit F6; ATPase subunit F6", "protein_names_refseq": "ATP synthase peripheral stalk subunit F6, mitochondrial; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F6; ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6; ATP synthase-coupling factor 6, mitochondrial; ATPase subunit F6", "tax_id": 10116, "disease": "essential hypertension (Disease Ontology:DOID:10825); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (rno:94271); (R-RNO-163210); (R-RNO-8949613); (R-RNO-9837999)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "1386054;1429613;17575325;2145831;22673903;25900768;26446791;27213235;27491388;27916219", "class_list": "", "function": "CF6 protein was upregulated in cardiac hypertrophy induced by hypertension; further mechanisms involved in this process should be investigated., [RefSeq, PubMed]; CF6 shRNA effectively inhibited CF6 expression, abolished lung macrophage infiltration, reversed endothelial dysfunction and vascular remodeling, and ameliorated the severity of pulmonary hypertension and right ventricular dysfunction at 4 weeks both as a pretreatment and rescue intervention Publication Status: Online-Only, [RefSeq, PubMed]; Plasma level increased markedly during pathogenesis of pulmonary arterial hypertension (PAH), indicating that CF6 may be involved in the development of PAH, [RefSeq, PubMed]; Subunit F6, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (By similarity). Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0015078 proton transmembrane transporter activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0009986 cell surface;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:1900139 negative regulation of arachidonate secretion;GO:0045777 positive regulation of blood pressure;GO:0010460 positive regulation of heart rate;GO:0032307 negative regulation of prostaglandin secretion;GO:0014850 response to muscle activity", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P21571-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22734-1", "uniprot_id": [ { "id": "COMT_RAT", "url": "https://www.uniprot.org/uniprot/P22734", "type": "external" } ], "mass": 29597.0, "length": 264, "protein_name": "Catechol O-methyltransferase", "gene_name": "Comt", "organism": "Rat", "refseq_name": "catechol O-methyltransferase", "refseq_ac": [ { "id": "NP_036663", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036663", "type": "external" } ], "gene_names_uniprotkb": "Comt", "gene_names_refseq": "Comt", "protein_names_uniprotkb": "Catechol O-methyltransferase; 2.1.1.6", "protein_names_refseq": "catechol O-methyltransferase; catecholamine-O-methyltransferase", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); withdrawal disorder (Disease Ontology:DOID:0060001); autism spectrum disorder (Disease Ontology:DOID:0060041); Parkinsonism (Disease Ontology:DOID:0080855); osteogenesis imperfecta type 7 (Disease Ontology:DOID:0110337); prostate cancer (Disease Ontology:DOID:10283); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); obsessive-compulsive disorder (Disease Ontology:DOID:10933); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); urinary bladder cancer (Disease Ontology:DOID:11054); polycystic ovary syndrome (Disease Ontology:DOID:11612); bulimia nervosa (Disease Ontology:DOID:12129); vitiligo (Disease Ontology:DOID:12306); pathological gambling (Disease Ontology:DOID:12399); intermittent explosive disorder (Disease Ontology:DOID:12401); leiomyoma (Disease Ontology:DOID:127); eumycotic mycetoma (Disease Ontology:DOID:13078); lung cancer (Disease Ontology:DOID:1324); endometrial cancer (Disease Ontology:DOID:1380); cognitive disorder (Disease Ontology:DOID:1561); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); cannabis dependence (Disease Ontology:DOID:1849); ovarian cancer (Disease Ontology:DOID:2394); opiate dependence (Disease Ontology:DOID:2559); morphine dependence (Disease Ontology:DOID:2560); bipolar disorder (Disease Ontology:DOID:3312); renal cell carcinoma (Disease Ontology:DOID:4450); uremia (Disease Ontology:DOID:4676); schizophrenia (Disease Ontology:DOID:5419); fibromyalgia (Disease Ontology:DOID:631); amphetamine abuse (Disease Ontology:DOID:670); psoriasis (Disease Ontology:DOID:8893); cannabis abuse (Disease Ontology:DOID:9505); neonatal abstinence syndrome (Disease Ontology:DOID:9828); obesity (Disease Ontology:DOID:9970); drug dependence (Disease Ontology:DOID:9974); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:24267); (R-RNO-156581); (R-RNO-379397); (R-RNO-379398)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "10785817;12237326;16618795;1765063;21454685;2227437;22673903;33503461;34725639;8127373;8280056", "class_list": "", "function": "Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]; Mechanism of Catechol-O-methyltransferase Regulating Orofacial Pain Induced by Tooth Movement. Publication Status: Online-Only, [RefSeq, PubMed]; Membrane bound catechol-O-methytransferase is the dominant isoform for dopamine metabolism in PC12 cells and rat brain., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 41, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.6", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0016206 catechol O-methyltransferase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0008210 estrogen metabolic process;GO:0046959 habituation;GO:0071626 mastication;GO:0021696 cerebellar cortex morphogenesis;GO:0001964 startle response", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P22734-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32232-1", "uniprot_id": [ { "id": "CBS_RAT", "url": "https://www.uniprot.org/uniprot/P32232", "type": "external" } ], "mass": 61455.0, "length": 561, "protein_name": "Cystathionine beta-synthase", "gene_name": "Cbs", "organism": "Rat", "refseq_name": "cystathionine beta-synthase", "refseq_ac": [ { "id": "NP_036654", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036654", "type": "external" } ], "gene_names_uniprotkb": "Cbs", "gene_names_refseq": "Cbs", "protein_names_uniprotkb": "Cystathionine beta-synthase; 4.2.1.22; Beta-thionase; Hemoprotein H-450; Serine sulfhydrase", "protein_names_refseq": "beta-thionase; cystathionine beta-synthase; hemoprotein H-450; serine sulfhydrase", "tax_id": 10116, "disease": "vitamin B12 deficiency (Disease Ontology:DOID:0050731); neural tube defect (Disease Ontology:DOID:0080074); malaria (Disease Ontology:DOID:12365); dilated cardiomyopathy (Disease Ontology:DOID:12930); Down syndrome (Disease Ontology:DOID:14250); breast cancer (Disease Ontology:DOID:1612); epilepsy (Disease Ontology:DOID:1826); colon cancer (Disease Ontology:DOID:219); ovarian cancer (Disease Ontology:DOID:2394); coronary artery disease (Disease Ontology:DOID:3393); cerebral infarction (Disease Ontology:DOID:3526); cytochrome-c oxidase deficiency disease (Disease Ontology:DOID:3762); homocystinuria (Disease Ontology:DOID:9263); hyperhomocysteinemia (Disease Ontology:DOID:9279)", "pathway": " (rno:24250); (R-RNO-1614603)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "1597473;20149843;2089036;22673903;32184133;35042677;37864623;8558235", "class_list": "", "function": "Cysteine becomes conditionally essential during hypobaric hypoxia and regulates adaptive neuro-physiological responses through CBS/H2S pathway., [RefSeq, PubMed]; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (PubMed:20149843, PubMed:8558235)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Overproduction of hydrogen sulfide, generated by cystathionine beta-synthase, disrupts brain wave patterns and contributes to neurobehavioral dysfunction in a rat model of down syndrome., [RefSeq, PubMed]; The Role of Cystathionine-beta-Synthase, H2S, and miRNA-377 in Hypoxic-Ischemic Encephalopathy: Insights from Human and Animal Studies., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.2.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.22", "type": "external" } ], "go_molecular_function": "GO:0019899 enzyme binding;GO:0030170 pyridoxal phosphate binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0001974 blood vessel remodeling;GO:0031667 response to nutrient levels;GO:0071456 cellular response to hypoxia;GO:0097746 blood vessel diameter maintenance", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P32232-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36972-1", "uniprot_id": [ { "id": "APT_RAT", "url": "https://www.uniprot.org/uniprot/P36972", "type": "external" } ], "mass": 19546.0, "length": 180, "protein_name": "Adenine phosphoribosyltransferase", "gene_name": "Aprt; Galns", "organism": "Rat", "refseq_name": "adenine phosphoribosyltransferase", "refseq_ac": [ { "id": "NP_001013079", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013079", "type": "external" } ], "gene_names_uniprotkb": "Aprt; Galns; Galns", "gene_names_refseq": "Aprt", "protein_names_uniprotkb": "Adenine phosphoribosyltransferase; 2.4.2.7; APRT", "protein_names_refseq": "adenine phosphoribosyltransferase", "tax_id": 10116, "disease": "adenine phosphoribosyltransferase deficiency (Disease Ontology:DOID:0060350); Lesch-Nyhan syndrome (Disease Ontology:DOID:1919); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:292072); (R-RNO-6798695); (R-RNO-74217)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "22673903;29393594;8112572", "class_list": "", "function": "Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" } ], "go_molecular_function": "GO:0016208 AMP binding;GO:0002055 adenine binding;GO:0003999 adenine phosphoribosyltransferase activity;GO:0043890 N-acetylgalactosamine-6-sulfatase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005764 lysosome", "go_biological_process": "GO:0032869 cellular response to insulin stimulus;GO:0044209 AMP salvage;GO:0007595 lactation;GO:0032264 IMP salvage;GO:0006166 purine ribonucleoside salvage", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P36972-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63182-1", "uniprot_id": [ { "id": "CBLN1_RAT", "url": "https://www.uniprot.org/uniprot/P63182", "type": "external" } ], "mass": 21083.0, "length": 193, "protein_name": "Cerebellin-1", "gene_name": "Cbln1", "organism": "Rat", "refseq_name": "cerebellin-1 precursor", "refseq_ac": [ { "id": "NP_001102597", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102597", "type": "external" } ], "gene_names_uniprotkb": "Cbln1", "gene_names_refseq": "Cbln1", "protein_names_uniprotkb": "Cerebellin-1; Precerebellin; [des-Ser1]CER; des-CER; des-Ser(1)-cerebellin; des-Ser1CER", "protein_names_refseq": "cerebellin 1 precursor protein; cerebellin-1 precursor; cerebellin-1; precerebellin", "tax_id": 10116, "disease": "", "pathway": " (rno:498922)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10688962;15702230;16593526;27033232;27926833;3399060;3420533", "class_list": "", "function": "Required for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the matching and maintenance of pre- and post-synaptic elements at parallel fiber-Purkinje cell synapses, the establishment of the proper pattern of climbing fiber-Purkinje cell innervation, and induction of long-term depression at parallel fiber-Purkinje cell synapses. Plays a role as a synaptic organizer that acts bidirectionally on both pre- and post-synaptic components. On the one hand induces accumulation of synaptic vesicles in the pre-synaptic part by binding with NRXN1 and in other hand induces clustering of GRID2 and its associated proteins at the post-synaptic site through association of GRID2. NRXN1-CBLN1-GRID2 complex directly induces parallel fiber protrusions that encapsulate spines of Purkinje cells leading to accumulation of GRID2 and synaptic vesicles. Required for CBLN3 export from the endoplasmic reticulum and secretion (By similarity). NRXN1-CBLN1-GRID2 complex mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis (By similarity). Essential for long-term maintenance but not establishment of excitatory synapses (By similarity). Inhibits the formation and function of inhibitory GABAergic synapses in cerebellar Purkinje cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Results determined the crystal structures of the trimeric C1q-like domain of cerebellin-1, and the first complete ectodomain of GluD2. Cerebellin binds to the LNS6 domain of alpha- and beta-neurexin-1 through a high-affinity interaction that involves its highly flexible N-terminal domain., [RefSeq, PubMed]; Study supports the hypothesis that developmental hypothyroxinemia and hypothyroidism reduce PF-PC synapses, which may be attributed to the downregulation of Neurexin1/Cbln1/GluD2 tripartite complex., [RefSeq, PubMed]; The cerebellin exerts neuromodulatory functions. Directly stimulates norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release. A conversion to [des-Ser1]-cerebellin by endopeptidases seems to be required for its autocrine-paracrine regulatory functions., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "P02682;P23436", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0030545 signaling receptor regulator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0045202 synapse;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0050808 synapse organization;GO:0051965 positive regulation of synapse assembly;GO:0099558 maintenance of synapse structure;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0009306 protein secretion", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P63182-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V7B0-1", "uniprot_id": [ { "id": "CF157_RAT", "url": "https://www.uniprot.org/uniprot/Q4V7B0", "type": "external" } ], "mass": 62791.0, "length": 542, "protein_name": "Cilia- and flagella-associated protein 157", "gene_name": "Cfap157", "organism": "Rat", "refseq_name": "cilia- and flagella-associated protein 157", "refseq_ac": [ { "id": "NP_001094339", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094339", "type": "external" } ], "gene_names_uniprotkb": "Cfap157", "gene_names_refseq": "Cfap157", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 157", "protein_names_refseq": "cilia- and flagella-associated protein 157; uncharacterized protein C9orf117 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:499781)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "Specifically required during spermatogenesis for flagellum morphogenesis and sperm motility. May be required to suppress the formation of supernumerary axonemes and ensure a correct ultrastructure., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0036064 ciliary basal body", "go_biological_process": "GO:0007288 sperm axoneme assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4V7B0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M875-1", "uniprot_id": [ { "id": "DHB13_RAT", "url": "https://www.uniprot.org/uniprot/Q5M875", "type": "external" } ], "mass": 33494.0, "length": 300, "protein_name": "17-beta-hydroxysteroid dehydrogenase 13", "gene_name": "Hsd17b13", "organism": "Rat", "refseq_name": "17-beta-hydroxysteroid dehydrogenase 13 precursor", "refseq_ac": [ { "id": "NP_001009684", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009684", "type": "external" } ], "gene_names_uniprotkb": "Hsd17b13; Scdr9", "gene_names_refseq": "Hsd17b13", "protein_names_uniprotkb": "17-beta-hydroxysteroid dehydrogenase 13; 1.1.1.-; 1.1.1.105; 1.1.1.62; 17-beta-HSD 13; Hepatic retinol/retinal dehydrogenase; Short-chain dehydrogenase/reductase 9", "protein_names_refseq": "17-beta-HSD 13; 17-beta-hydroxysteroid dehydrogenase 13 precursor; 17-beta-hydroxysteroid dehydrogenase 13; hepatic retinol/retinal dehydrogenase; short-chain dehydrogenase/reductase 9", "tax_id": 10116, "disease": "", "pathway": " (rno:305150); (R-RNO-8964572)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21454685;22673903", "class_list": "", "function": "Plays a pivotal role in hepatic lipid metabolism. In vitro, it catalyzes the oxidation of a variety of lipid substrates, including 17beta-estradiol, retinol, retinal, and leukotriene B4., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.105", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.105", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.209", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.209", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "1.1.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.1", "type": "external" }, { "id": "1.1.1.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.66", "type": "external" }, { "id": "1.1.1.315", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.315", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.2.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.19", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.1.1.n12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.n12", "type": "external" }, { "id": "1.1.1.330", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.330", "type": "external" } ], "go_molecular_function": "GO:0016229 steroid dehydrogenase activity;GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity;GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity;GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0046889 positive regulation of lipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5M875-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PQP4-1", "uniprot_id": [ { "id": "BORG1_RAT", "url": "https://www.uniprot.org/uniprot/Q5PQP4", "type": "external" } ], "mass": 23048.0, "length": 214, "protein_name": "Cdc42 effector protein 2", "gene_name": "Cdc42ep2", "organism": "Rat", "refseq_name": "cdc42 effector protein 2", "refseq_ac": [ { "id": "NP_001009689", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009689", "type": "external" } ], "gene_names_uniprotkb": "Cdc42ep2; Borg1; Cep2", "gene_names_refseq": "Cdc42ep2", "protein_names_uniprotkb": "Cdc42 effector protein 2; Binder of Rho GTPases 1", "protein_names_refseq": "CDC42 effector protein (Rho GTPase binding) 2; binder of Rho GTPases 1; cdc42 effector protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:309175); (R-RNO-5687128); (R-RNO-9013406)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0031267 small GTPase binding;GO:0001515 opioid peptide activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0007266 Rho protein signal transduction;GO:0008360 regulation of cell shape;GO:0031274 positive regulation of pseudopodium assembly;GO:0071346 cellular response to type II interferon", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5PQP4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RJK8-1", "uniprot_id": [ { "id": "ACBD6_RAT", "url": "https://www.uniprot.org/uniprot/Q5RJK8", "type": "external" } ], "mass": 30810.0, "length": 282, "protein_name": "Acyl-CoA-binding domain-containing protein 6", "gene_name": "Acbd6", "organism": "Rat", "refseq_name": "acyl-CoA-binding domain-containing protein 6", "refseq_ac": [ { "id": "NP_001011906", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011906", "type": "external" } ], "gene_names_uniprotkb": "Acbd6", "gene_names_refseq": "Acbd6", "protein_names_uniprotkb": "Acyl-CoA-binding domain-containing protein 6", "protein_names_refseq": "acyl-CoA-binding domain-containing protein 6; acyl-Coenzyme A binding domain containing 6", "tax_id": 10116, "disease": "", "pathway": " (rno:289125); (R-RNO-77289)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Binds long-chain acyl-coenzyme A molecules with a strong preference for unsaturated C18:1-CoA, lower affinity for unsaturated C20:4-CoA, and very weak affinity for saturated C16:0-CoA. Does not bind fatty acids (By similarity). Plays a role in protein N-myristoylation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding;GO:0000062 fatty-acyl-CoA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5RJK8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63686-1", "uniprot_id": [ { "id": "CDK16_RAT", "url": "https://www.uniprot.org/uniprot/Q63686", "type": "external" } ], "mass": 55875.0, "length": 496, "protein_name": "Cyclin-dependent kinase 16", "gene_name": "Cdk16", "organism": "Rat", "refseq_name": "cyclin-dependent kinase 16", "refseq_ac": [ { "id": "NP_001004132", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004132", "type": "external" } ], "gene_names_uniprotkb": "Cdk16; Pctaire1; Pctk1", "gene_names_refseq": "Cdk16; Pctk1", "protein_names_uniprotkb": "Cyclin-dependent kinase 16; 2.7.11.22; Cell division protein kinase 16; PCTAIRE-motif protein kinase 1; Serine/threonine-protein kinase PCTAIRE-1", "protein_names_refseq": "PCTAIRE protein kinase 1; PCTAIRE-1 protein kinase, alternatively spliced; PCTAIRE-motif protein kinase 1; cell division protein kinase 16; cyclin-dependent kinase 16; serine/threonine-protein kinase PCTAIRE-1", "tax_id": 10116, "disease": "", "pathway": " (rno:81741)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10727952;16461345;21982980;22673903;8918260", "class_list": "", "function": "Behavioral experiments suggested that overexpression of Pctk1 produces a deficit in learning and memory., [RefSeq, PubMed]; Pctaire1 phosphorylates N-ethylmaleimide-sensitive fusion protein, [RefSeq, PubMed]; Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Can phosphorylate CCNY at 'Ser-336' (in vitro) Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Regulates GH1 release by brain neurons. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Phosphorylates NSF, and thereby regulates NSF oligomerization., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A9K3Y885;Q63687", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0007283 spermatogenesis;GO:0031175 neuron projection development;GO:0010508 positive regulation of autophagy;GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0006887 exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q63686-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66H98-1", "uniprot_id": [ { "id": "CAVN2_RAT", "url": "https://www.uniprot.org/uniprot/Q66H98", "type": "external" } ], "mass": 46386.0, "length": 417, "protein_name": "Caveolae-associated protein 2", "gene_name": "Cavin2", "organism": "Rat", "refseq_name": "caveolae-associated protein 2", "refseq_ac": [ { "id": "NP_001007713", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007713", "type": "external" } ], "gene_names_uniprotkb": "Cavin2; Sdpr", "gene_names_refseq": "Cavin2", "protein_names_uniprotkb": "Caveolae-associated protein 2; Cavin-2; Phosphatidylserine-binding protein; Serum deprivation-response protein", "protein_names_refseq": "caveolae-associated protein 2; cavin-2; phosphatidylserine-binding protein; serum deprivation response; serum deprivation-response protein", "tax_id": 10116, "disease": "", "pathway": " (rno:316384)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "22673903;25618412;29393594;36335812;9566962", "class_list": "", "function": "Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae. Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells (By similarity). May play a role in targeting PRKCA to caveolae (PubMed:9566962)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; The SDPR protein was observed to be present only at the time of fertilisation, and also under the influence of oestrogen alone, where a cytoplasmic localisation in uterine epithelial cells was observed., [RefSeq, PubMed]; The mechanism and biomarker function of Cavin-2 in lung ischemia-reperfusion injury., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 22, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005080 protein kinase C binding;GO:0001786 phosphatidylserine binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0045121 membrane raft;GO:0005901 caveola", "go_biological_process": "GO:0097320 plasma membrane tubulation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q66H98-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AY97-1", "uniprot_id": [ { "id": "CCD91_RAT", "url": "https://www.uniprot.org/uniprot/Q6AY97", "type": "external" } ], "mass": 50166.0, "length": 442, "protein_name": "Coiled-coil domain-containing protein 91", "gene_name": "Ccdc91", "organism": "Rat", "refseq_name": "coiled-coil domain-containing protein 91", "refseq_ac": [ { "id": "NP_001014083", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014083", "type": "external" } ], "gene_names_uniprotkb": "Ccdc91; Ggabp", "gene_names_refseq": "Ccdc91", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 91; GGA-binding partner", "protein_names_refseq": "GGA-binding partner; coiled-coil domain-containing protein 91-like; coiled-coil domain-containing protein 91", "tax_id": 10116, "disease": "", "pathway": " (rno:312863)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "Involved in the regulation of membrane traffic through the trans-Golgi network (TGN). Functions in close cooperation with the GGAs in the sorting of hydrolases to lysosomes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0016020 membrane;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0015031 protein transport;GO:0090160 Golgi to lysosome transport;GO:0048193 Golgi vesicle transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6AY97-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q71RJ2-1", "uniprot_id": [ { "id": "CCG2_RAT", "url": "https://www.uniprot.org/uniprot/Q71RJ2", "type": "external" } ], "mass": 35895.0, "length": 323, "protein_name": "Voltage-dependent calcium channel gamma-2 subunit", "gene_name": "Cacng2", "organism": "Rat", "refseq_name": "voltage-dependent calcium channel gamma-2 subunit", "refseq_ac": [ { "id": "NP_445803", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445803", "type": "external" } ], "gene_names_uniprotkb": "Cacng2; Stg", "gene_names_refseq": "Cacng2; Ipr328", "protein_names_uniprotkb": "Voltage-dependent calcium channel gamma-2 subunit; Neuronal voltage-gated calcium channel gamma-2 subunit; Stargazin; TARP gamma-2; Transmembrane AMPAR regulatory protein gamma-2", "protein_names_refseq": "TARP gamma-2; calcium channel, voltage-dependent, gamma subunit 2; neuronal voltage-gated calcium channel gamma-2 subunit; stargazin; transmembrane AMPAR regulatory protein gamma-2; voltage-dependent calcium channel gamma-2 subunit", "tax_id": 10116, "disease": "autosomal dominant intellectual developmental disorder 10 (Disease Ontology:DOID:0070040); childhood absence epilepsy (Disease Ontology:DOID:1825)", "pathway": " (rno:84347); (R-RNO-112308); (R-RNO-399719); (R-RNO-5682910)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "11738816;17880894;18817736;19234459;19265014;20805473;22673903;26742808;27368053;27756895;28823560", "class_list": "", "function": "Cryo-EM structure of the homomeric GluA2 AMPA receptor saturated with TARP gamma2 subunits, showing how the TARPs are arranged with four-fold symmetry around the ion channel domain and make extensive interactions with the M1, M2 and M4 transmembrane helices, [RefSeq, PubMed]; Evidence indicates that alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptors (AMPARs) are important modulators of alcohol self-administration and relapse-like behavior., [RefSeq, PubMed]; Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Study elucidates structures of the GluA2-TARP gamma2 complex in the presence of the partial agonist kainate or the full agonist quisqualate together with a positive allosteric modulator or with quisqualate alone. Structural and computational analysis suggests the full agonist and modulator complex harbors an ion-permeable channel gate, providing the first view of an activated AMPA receptor., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005246 calcium channel regulator activity;GO:0005245 voltage-gated calcium channel activity;GO:0035255 ionotropic glutamate receptor binding;GO:0016247 channel regulator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0009986 cell surface;GO:0032281 AMPA glutamate receptor complex;GO:0036477 somatodendritic compartment;GO:0044300 cerebellar mossy fiber", "go_biological_process": "GO:1904510 positive regulation of protein localization to basolateral plasma membrane;GO:0007528 neuromuscular junction development;GO:0042391 regulation of membrane potential;GO:0051592 response to calcium ion;GO:0006612 protein targeting to membrane", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q71RJ2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EPY0-1", "uniprot_id": [ { "id": "CARD9_RAT", "url": "https://www.uniprot.org/uniprot/Q9EPY0", "type": "external" } ], "mass": 62632.0, "length": 536, "protein_name": "Caspase recruitment domain-containing protein 9", "gene_name": "Card9", "organism": "Rat", "refseq_name": "caspase recruitment domain-containing protein 9", "refseq_ac": [ { "id": "NP_071639", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071639", "type": "external" } ], "gene_names_uniprotkb": "Card9", "gene_names_refseq": "Card9", "protein_names_uniprotkb": "Caspase recruitment domain-containing protein 9; rCARD9", "protein_names_refseq": "caspase recruitment domain protein 9; caspase recruitment domain-containing protein 9; rCARD9", "tax_id": 10116, "disease": "primary immunodeficiency disease (Disease Ontology:DOID:612); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (rno:64171); (R-RNO-5607764)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11053425;17936701;22673903;27957800;31212066;32248306;32790017", "class_list": "", "function": "Adapter protein that plays a key role in innate immune response against fungi by forming signaling complexes downstream of C-type lectin receptors (By similarity). CARD9-mediated signals are essential for antifungal immunity against a subset of fungi from the phylum Ascomycota (By similarity). Transduces signals in myeloid cells downstream of C-type lectin receptors CLEC7A (dectin-1), CLEC6A (dectin-2) and CLEC4E (Mincle), which detect pathogen-associated molecular pattern metabolites (PAMPs), such as fungal carbohydrates, and trigger CARD9 activation (PubMed:17936701). Upon activation, CARD9 homooligomerizes to form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10 and subsequent recruitment of MALT1: this leads to activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:17936701). CARD9 signaling in antigen-presenting cells links innate sensing of fungi to the activation of adaptive immunity and provides a cytokine milieu that induces the development and subsequent of interleukin 17-producing T helper (Th17) cells (By similarity). Also involved in activation of myeloid cells via classical ITAM-associated receptors and TLR: required for TLR-mediated activation of MAPK, while it is not required for TLR-induced activation of NF-kappa-B (By similarity). CARD9 can also be engaged independently of BCL10: forms a complex with RASGRF1 downstream of C-type lectin receptors, which recruits and activates HRAS, leading to ERK activation and the production of cytokines (By similarity). Acts as an important regulator of the intestinal commensal fungi (mycobiota) component of the gut microbiota (By similarity). Plays an essential role in antifungal immunity against dissemination of gut fungi: acts by promoting induction of antifungal IgG antibodies response in CX3CR1(+) macrophages to confer protection against disseminated C.albicans or C.auris infection (By similarity). Also mediates immunity against other pathogens, such as certain bacteria, viruses and parasites; CARD9 signaling is however redundant with other innate immune responses (By similarity). In response to L.monocytogenes infection, required for the production of inflammatory cytokines activated by intracellular peptidoglycan: acts by connecting NOD2 recognition of peptidoglycan to downstream activation of MAP kinases (MAPK) without activating NF-kappa-B (By similarity)., [UniProtKB, UniProtKB, PubMed]; CARD9 promotes autophagy in cardiomyocytes in myocardial ischemia/reperfusion injury via interacting with Rubicon directly. Publication Status: Online-Only, [RefSeq, PubMed]; CARD9 protects cardiomyocytes from apoptosis by interacting with Apaf-1 and interfering with apoptosome formation following myocardial ischemia/reperfusion injury in vivo and in vitro, [RefSeq, PubMed]; Role of CARD9 in inflammatory signal pathway of peritoneal macrophages in severe acute pancreatitis., [RefSeq, PubMed]; SiRNAs showed that the reduction of CARD9 in severe acute pancreatitis (SAP)rats down-regulated the expression of NF-kappaBp65 and P38MAPK which are involved in the transcription and release of a wide variety of inflammatory cytokines, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1LQK8", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0035591 signaling adaptor activity;GO:0050700 CARD domain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0032991 protein-containing complex;GO:0032449 CBM complex", "go_biological_process": "GO:0032740 positive regulation of interleukin-17 production;GO:0007165 signal transduction;GO:0046330 positive regulation of JNK cascade;GO:0050830 defense response to Gram-positive bacterium;GO:0051260 protein homooligomerization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9EPY0-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ERR2-1", "uniprot_id": [ { "id": "COMD5_RAT", "url": "https://www.uniprot.org/uniprot/Q9ERR2", "type": "external" } ], "mass": 24453.0, "length": 224, "protein_name": "COMM domain-containing protein 5", "gene_name": "Commd5", "organism": "Rat", "refseq_name": "COMM domain-containing protein 5", "refseq_ac": [ { "id": "NP_620808", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620808", "type": "external" } ], "gene_names_uniprotkb": "Commd5", "gene_names_refseq": "Commd5; Hcarg", "protein_names_uniprotkb": "COMM domain-containing protein 5; HCaRG; Hypertension-related calcium-regulated gene protein", "protein_names_refseq": "COMM domain-containing protein 5; hypertension-related calcium-regulated gene protein; hypertension-related, calcium regulated", "tax_id": 10116, "disease": "", "pathway": " (rno:245974); (R-RNO-8951664)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10918053;11871861;12620924;16033922;18949406;24515317", "class_list": "", "function": "Data support a role for HCaRG in kidney repair after injury through its effect on renal cell migration and TGF-alpha secretion, [RefSeq, PubMed]; HCaRG regulates renal epithelial cell growth and differentiation causing G(2)M cell cycle arrest, [RefSeq, PubMed]; Hcarg localizes to the rat chromosome 7 between the markers Mit3 and Mit4. We identified a BglII RFLP between BN.lx and SHR rats., [RefSeq, PubMed]; Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (By similarity). May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (By similarity). Negatively regulates cell proliferation (PubMed:12620924). Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway (PubMed:12620924). Involved in kidney proximal tubule morphogenesis (PubMed:24515317). Down-regulates activation of NF-kappa-B (By similarity)., [UniProtKB, UniProtKB]; The up-regulation of HCaRG may be one of the mechanisms underlying the chemopreventive effect of rosiglitazone in gastric cancer., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0030858 positive regulation of epithelial cell differentiation;GO:0006351 DNA-templated transcription;GO:0030307 positive regulation of cell growth;GO:0072158 proximal tubule morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9ERR2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QUR2-1", "uniprot_id": [ { "id": "DCTN4_RAT", "url": "https://www.uniprot.org/uniprot/Q9QUR2", "type": "external" } ], "mass": 53089.0, "length": 467, "protein_name": "Dynactin subunit 4", "gene_name": "Dctn4", "organism": "Rat", "refseq_name": "dynactin subunit 4 isoform 1", "refseq_ac": [ { "id": "NP_445856", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445856", "type": "external" } ], "gene_names_uniprotkb": "Dctn4", "gene_names_refseq": "Dctn4", "protein_names_uniprotkb": "Dynactin subunit 4; Dynactin subunit p62", "protein_names_refseq": "dynactin 4 (p62); dynactin subunit 4 isoform 1; dynactin subunit p62", "tax_id": 10116, "disease": "", "pathway": " (rno:84428); (R-RNO-2132295); (R-RNO-3371497); (R-RNO-6807878); (R-RNO-6811436)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "10525537;10607597;16641100", "class_list": "", "function": "Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9QXP8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000922 spindle pole;GO:0005813 centrosome;GO:0005925 focal adhesion;GO:0005938 cell cortex;GO:0001725 stress fiber", "go_biological_process": "GO:0007017 microtubule-based process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9QUR2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R1Q2-1", "uniprot_id": [ { "id": "CCNL1_RAT", "url": "https://www.uniprot.org/uniprot/Q9R1Q2", "type": "external" } ], "mass": 59791.0, "length": 527, "protein_name": "Cyclin-L1", "gene_name": "Ccnl1", "organism": "Rat", "refseq_name": "cyclin-L1", "refseq_ac": [ { "id": "NP_446114", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446114", "type": "external" } ], "gene_names_uniprotkb": "Ccnl1; Ania6a", "gene_names_refseq": "Ania-6a; Ccnl1; Ccnl", "protein_names_uniprotkb": "Cyclin-L1; Cyclin Ania-6a; Cyclin-L", "protein_names_refseq": "cyclin Ania-6a; cyclin-L1-like; cyclin-L1; cyclin-L", "tax_id": 10116, "disease": "", "pathway": " (rno:114121)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11683997;12807435;16537916;22673903;9651213", "class_list": "", "function": "Ania-6 transcription is mostly regulated via cAMP response element binding protein (CREB), but that signaling pathways that converge on CREB at the transcriptional level produce different effects on splicing and neuronal gene expression, [RefSeq, PubMed]; CDK12 and cyclin L1/L2 are cyclin-dependent kinase and cyclin partners and regulate alternative splicing., [RefSeq, PubMed]; Regulatory component of the cyclin-L-CDK11 complex that regulates transcription and pre-mRNA splicing (PubMed:11683997). Inhibited by the CDK-specific inhibitor CDKN1A/p21 (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5U364", "ec_number_list": [], "go_molecular_function": "GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0016604 nuclear body;GO:0000307 cyclin-dependent protein kinase holoenzyme complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0043484 regulation of RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9R1Q2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTT7-1", "uniprot_id": [ { "id": "5MP1_RAT", "url": "https://www.uniprot.org/uniprot/Q9WTT7", "type": "external" } ], "mass": 48049.0, "length": 419, "protein_name": "eIF5-mimic protein 1", "gene_name": "Bzw2", "organism": "Rat", "refseq_name": "eIF5-mimic protein 1", "refseq_ac": [ { "id": "NP_599229", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599229", "type": "external" } ], "gene_names_uniprotkb": "Bzw2; 5mp1; Bdm2; Hfb2", "gene_names_refseq": "Bzw2; Hfb2", "protein_names_uniprotkb": "eIF5-mimic protein 1; Basic leucine zipper and W2 domain-containing protein 2; Brain development-related molecule 2", "protein_names_refseq": "basic leucine zipper and W2 domain-containing protein 2; brain development-related molecule 2; eIF5-mimic protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:171439)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10727730;22673903", "class_list": "", "function": "Translation initiation regulator which represses non-AUG initiated translation and repeat-associated non-AUG (RAN) initiated translation by acting as a competitive inhibitor of eukaryotic translation initiation factor 5 (EIF5) function (By similarity). Increases the accuracy of translation initiation by impeding EIF5-dependent translation from non-AUG codons by competing with it for interaction with EIF2S2 within the 43S pre-initiation complex (PIC) in an EIF3C-binding dependent manner (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006446 regulation of translational initiation;GO:0006417 regulation of translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9WTT7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97686-1", "uniprot_id": [ { "id": "NRCAM_RAT", "url": "https://www.uniprot.org/uniprot/P97686", "type": "external" } ], "mass": 133912.0, "length": 1214, "protein_name": "Neuronal cell adhesion molecule", "gene_name": "Nrcam", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Nrcam", "gene_names_refseq": "", "protein_names_uniprotkb": "Neuronal cell adhesion molecule; Ankyrin-binding cell adhesion molecule NrCAM; Neuronal surface protein Bravo; Ng-CAM-related; NgCAM-related cell adhesion molecule; Nr-CAM; rBravo", "protein_names_refseq": "", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); MASA syndrome (Disease Ontology:DOID:0060246); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (rno:497815)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1039/D0MO00044B;16039564;16641100;22673903;24090084;34106099;38843836;8947556", "class_list": "", "function": "Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons (By similarity). Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons (PubMed:16039564). Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 11, "predicted_n_glycosites": 9, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 7, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 7, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 7, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 19, "disease_count": 3, "glyco_site_count": 18, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030506 ankyrin binding;GO:0098632 cell-cell adhesion mediator activity;GO:0086080 protein binding involved in heterotypic cell-cell adhesion", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0030424 axon;GO:0045202 synapse", "go_biological_process": "GO:0001525 angiogenesis;GO:0007155 cell adhesion;GO:0007417 central nervous system development;GO:0098609 cell-cell adhesion;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "P97686-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43322-1", "uniprot_id": [ { "id": "NRG1_RAT", "url": "https://www.uniprot.org/uniprot/P43322", "type": "external" } ], "mass": 73288.0, "length": 662, "protein_name": "Pro-neuregulin-1, membrane-bound isoform", "gene_name": "Nrg1", "organism": "Rat", "refseq_name": "pro-neuregulin-1, membrane-bound isoform isoform 6", "refseq_ac": [ { "id": "NP_001258052", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258052", "type": "external" } ], "gene_names_uniprotkb": "Nrg1; Ndf", "gene_names_refseq": "Nrg1", "protein_names_uniprotkb": "Pro-neuregulin-1, membrane-bound isoform; ARIA; Acetylcholine receptor-inducing activity; Glial growth factor; HRG; Heregulin; Neu differentiation factor; Pro-NRG1; Sensory and motor neuron-derived factor", "protein_names_refseq": "glial growth factor; neuregulin 1 type III beta 3; pro-NRG1; pro-neuregulin-1, membrane-bound isoform isoform 6", "tax_id": 10116, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); obstructive sleep apnea (Disease Ontology:DOID:0050848); schizophrenia 6 (Disease Ontology:DOID:0070082); overactive bladder syndrome (Disease Ontology:DOID:0070355); amblyopia (Disease Ontology:DOID:10376); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); Alzheimer's disease (Disease Ontology:DOID:10652); sciatic neuropathy (Disease Ontology:DOID:11446); dementia (Disease Ontology:DOID:1307); interstitial cystitis (Disease Ontology:DOID:13949); cerebral malaria (Disease Ontology:DOID:14069); major depressive disorder (Disease Ontology:DOID:1470); alcohol use disorder (Disease Ontology:DOID:1574); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); cannabis dependence (Disease Ontology:DOID:1849); transient cerebral ischemia (Disease Ontology:DOID:224); ovarian cancer (Disease Ontology:DOID:2394); psychotic disorder (Disease Ontology:DOID:2468); substance abuse (Disease Ontology:DOID:302); bipolar disorder (Disease Ontology:DOID:3312); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); middle cerebral artery infarction (Disease Ontology:DOID:3525); tuberculosis (Disease Ontology:DOID:399); schizophrenia (Disease Ontology:DOID:5419); median neuropathy (Disease Ontology:DOID:571); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); neuropathy (Disease Ontology:DOID:870); cannabis abuse (Disease Ontology:DOID:9505); diabetic neuropathy (Disease Ontology:DOID:9743)", "pathway": " (rno:112400)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "1348215;1349853;16641100;17250808;34273906;35370955;35416257;35883098;36584915;7509448;9685409;9852099", "class_list": "", "function": "Changes in Type II NRG-1 Expression during Regeneration Following Autologous Nerve Transplantation in Rats., [RefSeq, PubMed]; Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Binds to ERBB4 and ERBB3. Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling (By similarity). Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1, and ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (PubMed:17250808)., [UniProtKB, PubMed, UniProtKB]; Effect of regulation of the NRG1/ErbB4 signaling pathway on the visual cortex synaptic plasticity of amblyopic adult rats., [RefSeq, PubMed]; MOTS-c and Exercise Restore Cardiac Function by Activating of NRG1-ErbB Signaling in Diabetic Rats. Publication Status: Online-Only, [RefSeq, PubMed]; MOTS-c and aerobic exercise induce cardiac physiological adaptation via NRG1/ErbB4/CEBPbeta modification in rats., [RefSeq, PubMed]; Neuregulin-1 signaling regulates cytokines and chemokines expression and secretion in granulosa cell. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 31, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "P43323;P43324;P43325;P43326;P43327;P43328", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005178 integrin binding;GO:0008270 zinc ion binding;GO:0030296 protein tyrosine kinase activator activity;GO:0030971 receptor tyrosine kinase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0048680 positive regulation of axon regeneration;GO:0046579 positive regulation of Ras protein signal transduction;GO:0021781 glial cell fate commitment;GO:1990416 cellular response to brain-derived neurotrophic factor stimulus;GO:0060379 cardiac muscle cell myoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P43322-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R426-1", "uniprot_id": [ { "id": "KCIP1_RAT", "url": "https://www.uniprot.org/uniprot/Q8R426", "type": "external" } ], "mass": 26817.0, "length": 227, "protein_name": "A-type potassium channel modulatory protein KCNIP1", "gene_name": "Kcnip1", "organism": "Rat", "refseq_name": "A-type potassium channel modulatory protein KCNIP1 isoform 3", "refseq_ac": [ { "id": "NP_001248318", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001248318", "type": "external" } ], "gene_names_uniprotkb": "Kcnip1; Kchip1", "gene_names_refseq": "Kchip1; Kcnip1", "protein_names_uniprotkb": "A-type potassium channel modulatory protein KCNIP1; KChIP1; Kv channel-interacting protein 1; Potassium channel-interacting protein 1", "protein_names_refseq": "A-type potassium channel modulatory protein 1; A-type potassium channel modulatory protein KCNIP1 isoform 3; A-type potassium channel modulatory protein KCNIP1; Kv channel-interacting protein 1; potassium channel-interacting protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:65023); (R-RNO-5576894)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10676964;11263977;11423117;12138168;12646414;14980206;15356203;19896980;20849929;24037673;25917026", "class_list": "", "function": "Aph1b and KCnIP1 are significantly differentially expressed in a number of brain tissues of a schizophrenia model; KCnIP1 is an attractive novel candidate gene that may play a role in the complex phenotype, [RefSeq, PubMed]; Hypothesis that occlusion of the inner vestibule of the Na(+) channel by the fast inactivation gate inhibits ultra-slow inactivation (mu1 sodium channel), [RefSeq, PubMed]; KChIP1 is selectively expressed in BLA interneurons where it may function to regulate the activity of A-type potassium channels. Hence, KChIP1 might be considered as a specific regulator of GABAergic inhibitory circuits in the basolateral amygdala., [RefSeq, PubMed]; KChIP1 plays a neuroprotective role against 4-AP acute induced cell death in primary hippocampal cells through regulation of Kv 4.3 and GABA transmission but this is lost after long term exposure., [RefSeq, PubMed]; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels (PubMed:14980206). Regulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner (PubMed:14980206). Modulates KCND2/Kv4.2 currents (PubMed:14980206). In vitro, modulates KCND1/Kv4.1 currents (By similarity). Increases the presence of KCND2 at the cell surface (PubMed:14980206)., [UniProtKB, PubMed, UniProtKB, PubMed]; The features of KChIP1b modulation of Kv4 channels are likely to be conserved in mammals and demonstrate a role for the KChIP1 NH2-terminal region in the regulation of closed inactivation gating., [RefSeq, PubMed]; This study demonistrared that the expression and function of KCHIP1 channels in neurons of the rat bed nucleus of the stria terminalis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q793P9;Q8CIR1;Q8R425", "ec_number_list": [], "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0005509 calcium ion binding;GO:0044877 protein-containing complex binding;GO:0005267 potassium channel activity", "go_cellular_component": "GO:0034705 potassium channel complex;GO:0005737 cytoplasm;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0009966 regulation of signal transduction;GO:0045760 positive regulation of action potential", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8R426-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88900-1", "uniprot_id": [ { "id": "GRB14_RAT", "url": "https://www.uniprot.org/uniprot/O88900", "type": "external" } ], "mass": 60593.0, "length": 538, "protein_name": "Growth factor receptor-bound protein 14", "gene_name": "Grb14", "organism": "Rat", "refseq_name": "growth factor receptor-bound protein 14", "refseq_ac": [ { "id": "NP_113811", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113811", "type": "external" } ], "gene_names_uniprotkb": "Grb14", "gene_names_refseq": "Grb14", "protein_names_uniprotkb": "Growth factor receptor-bound protein 14; GRB14 adapter protein", "protein_names_refseq": "GRB14 adapter protein; growth factor receptor-bound protein 14", "tax_id": 10116, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:58844); (R-RNO-210993)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "22673903;24350791;25578860;9748281", "class_list": "", "function": "Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The phosphorylation status of the BPS region of Grb14 determines the positive or negative role it will play in insulin receptor signaling. Publication Status: Online-Only, [RefSeq, PubMed]; These results show that Chfr and Grb14 collaborate in a negative feedback loop controlling insulin-stimulated cell division., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0030674 protein-macromolecule adaptor activity;GO:0051219 phosphoprotein binding;GO:0030971 receptor tyrosine kinase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0032869 cellular response to insulin stimulus;GO:0035556 intracellular signal transduction;GO:0008286 insulin receptor signaling pathway;GO:1904145 negative regulation of meiotic cell cycle process involved in oocyte maturation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O88900-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49185-1", "uniprot_id": [ { "id": "MK08_RAT", "url": "https://www.uniprot.org/uniprot/P49185", "type": "external" } ], "mass": 46807.0, "length": 411, "protein_name": "Mitogen-activated protein kinase 8", "gene_name": "Mapk8", "organism": "Rat", "refseq_name": "mitogen-activated protein kinase 8", "refseq_ac": [ { "id": "NP_446281", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446281", "type": "external" } ], "gene_names_uniprotkb": "Mapk8; Jnk1; Prkm8", "gene_names_refseq": "JNK; Mapk8", "protein_names_uniprotkb": "Mitogen-activated protein kinase 8; 2.7.11.24; MAP kinase 8; MAPK 8; SAPK gamma; Stress-activated protein kinase JNK1; c-Jun N-terminal kinase 1; p54 gamma", "protein_names_refseq": "MAP kinase 8; MAPK 8; SAPK gamma; c-Jun N-terminal kinase 1; c-jun NH2-terminal kinase; mitogen-activated protein kinase 8; p54 gamma; stress-activated protein kinase JNK1", "tax_id": 10116, "disease": "colorectal adenoma (Disease Ontology:DOID:0050860); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); stroke (Disease Ontology:DOID:0051061); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Parkinsonism (Disease Ontology:DOID:0080855); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); rectal benign neoplasm (Disease Ontology:DOID:1984); chronic mucocutaneous candidiasis (Disease Ontology:DOID:2058); brain ischemia (Disease Ontology:DOID:2316); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); abdominal aortic aneurysm (Disease Ontology:DOID:7693); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:116554); (R-RNO-111446); (R-RNO-139910); (R-RNO-193648); (R-RNO-2559580); (R-RNO-2871796); (R-RNO-450321); (R-RNO-450341); (R-RNO-5693565); (R-RNO-9007892)", "pathway_count": 10, "publication_count": 25, "publication_id_list": "11121042;14499478;14985449;16618812;17403295;17761173;21151908;21297631;22362362;23139803;23280045;23372792;23554623;24386130;25120278;25978724;29166604;29595913;29882093;32844579;35033142;37325630;38302075;8177321;9516415", "class_list": "", "function": "Anti-high-mobility group box-1 (HMGB1) mediates the apoptosis of alveolar epithelial cells (AEC) by receptor of advanced glycation end-products (RAGE)/c-Jun N-terminal kinase (JNK) pathway in the rats of crush injuries. Publication Status: Online-Only, [RefSeq, PubMed]; Chronic intermittent hypoxia-induced oxidative stress activates TRB3 and phosphorylated JNK to mediate insulin resistance and cell apoptosis in the pancreas., [RefSeq, PubMed]; MAPK8 and CAPN1 as potential biomarkers of intervertebral disc degeneration overlapping immune infiltration, autophagy, and ceRNA. Publication Status: Online-Only, [RefSeq, PubMed]; Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death (PubMed:16618812, PubMed:9516415). Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. Phosphorylates the replication licensing factor CDT1, inhibiting the interaction between CDT1 and the histone H4 acetylase HBO1 to replication origins. Loss of this interaction abrogates the acetylation required for replication initiation. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including p53/TP53 and Yes-associates protein YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Contributes to the survival of erythroid cells by phosphorylating the antagonist of cell death BAD upon EPO stimulation. Mediates starvation-induced BCL2 phosphorylation, BCL2 dissociation from BECN1, and thus activation of autophagy. Phosphorylates STMN2 and hence regulates microtubule dynamics, controlling neurite elongation in cortical neurons. In the developing brain, through its cytoplasmic activity on STMN2, negatively regulates the rate of exit from multipolar stage and of radial migration from the ventricular zone (PubMed:21297631). Phosphorylates several other substrates including heat shock factor protein 4 (HSF4), the deacetylase SIRT1, ELK1, or the E3 ligase ITCH. Phosphorylates the CLOCK-BMAL1 heterodimer and plays a role in the regulation of the circadian clock (By similarity). Phosphorylates the heat shock transcription factor HSF1, suppressing HSF1-induced transcriptional activity (By similarity). Phosphorylates POU5F1, which results in the inhibition of POU5F1's transcriptional activity and enhances its proteasomal degradation (By similarity). Phosphorylates JUND and this phosphorylation is inhibited in the presence of MEN1 (By similarity). In neurons, phosphorylates SYT4 which captures neuronal dense core vesicles at synapses (PubMed:29166604). Phosphorylates EIF4ENIF1/4-ET in response to oxidative stress, promoting P-body assembly (By similarity). Phosphorylates SIRT6 in response to oxidative stress, stimulating its mono-ADP-ribosyltransferase activity (By similarity). Phosphorylates NLRP3, promoting assembly of the NLRP3 inflammasome (By similarity). Phosphorylates ALKBH5 in response to reactive oxygen species (ROS), promoting ALKBH5 sumoylation and inactivation (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, PubMed]; The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. [provided by RefSeq, Jul 2012]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 19, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0042826 histone deacetylase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0007258 JUN phosphorylation;GO:0061833 protein localization to tricellular tight junction;GO:0038127 ERBB signaling pathway;GO:0006468 protein phosphorylation;GO:0006979 response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P49185-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B4F7E8-1", "uniprot_id": [ { "id": "NIBA2_RAT", "url": "https://www.uniprot.org/uniprot/B4F7E8", "type": "external" } ], "mass": 84731.0, "length": 747, "protein_name": "Protein Niban 2", "gene_name": "Niban2", "organism": "Rat", "refseq_name": "protein Niban 2", "refseq_ac": [ { "id": "NP_001103355", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103355", "type": "external" } ], "gene_names_uniprotkb": "Niban2; Fam129b", "gene_names_refseq": "Fam129b; Meg-3; Niban2; RGD1307018", "protein_names_uniprotkb": "Protein Niban 2; Meg-3; Niban-like protein 1; Protein FAM129B", "protein_names_refseq": "family with sequence similarity 129, member B; niban-like protein 1; protein Niban 2", "tax_id": 10116, "disease": "", "pathway": " (rno:362115)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "May play a role in apoptosis suppression., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0032274 gonadotropin secretion;GO:0008285 negative regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0045892 negative regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B4F7E8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SGE0-1", "uniprot_id": [ { "id": "LPPRC_RAT", "url": "https://www.uniprot.org/uniprot/Q5SGE0", "type": "external" } ], "mass": 156653.0, "length": 1392, "protein_name": "Leucine-rich PPR motif-containing protein, mitochondrial", "gene_name": "Lrpprc", "organism": "Rat", "refseq_name": "leucine-rich PPR motif-containing protein, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001008519", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008519", "type": "external" } ], "gene_names_uniprotkb": "Lrpprc; Lrp157", "gene_names_refseq": "Lrp157; Lrpprc", "protein_names_uniprotkb": "Leucine-rich PPR motif-containing protein, mitochondrial; 130 kDa leucine-rich protein; LRP 130; Leucine rich protein 157; rLRP157", "protein_names_refseq": "130 kDa leucine-rich protein; LRP 130; leucine-rich PPR motif-containing protein, mitochondrial precursor; leucine-rich PPR motif-containing protein, mitochondrial; leucine-rich PPR-motif containing; leucine-rich protein 157; rLRP157", "tax_id": 10116, "disease": "French Canadian Leigh disease (Disease Ontology:DOID:0111180); Leigh disease (Disease Ontology:DOID:3652)", "pathway": " (rno:313867)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15525270;22673903", "class_list": "", "function": "May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. Positively modulates nuclear export of mRNAs containing the EIF4E sensitivity element (4ESE) by binding simultaneously to both EIF4E and the 4ESE and acting as a platform for assembly for the RNA export complex (By similarity). Also binds to exportin XPO1/CRM1 to engage the nuclear pore and traffic the bound mRNAs to the cytoplasm (By similarity). May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity). Required for maintaining mitochondrial potential (By similarity). Suppresses the initiation of basal levels of autophagy and mitophagy by sustaining BCL2 levels (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0031625 ubiquitin protein ligase binding;GO:0048487 beta-tubulin binding;GO:0003730 mRNA 3'-UTR binding", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006914 autophagy;GO:0070129 regulation of mitochondrial translation;GO:0097222 mitochondrial mRNA polyadenylation;GO:0051028 mRNA transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5SGE0-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P05696-1", "uniprot_id": [ { "id": "KPCA_RAT", "url": "https://www.uniprot.org/uniprot/P05696", "type": "external" } ], "mass": 76792.0, "length": 672, "protein_name": "Protein kinase C alpha type", "gene_name": "Prkca", "organism": "Rat", "refseq_name": "protein kinase C alpha type isoform 1", "refseq_ac": [ { "id": "NP_001386228", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001386228", "type": "external" } ], "gene_names_uniprotkb": "Prkca; Pkca", "gene_names_refseq": "Pkca; Prkca", "protein_names_uniprotkb": "Protein kinase C alpha type; 2.7.11.13; PKC-A; PKC-alpha", "protein_names_refseq": "PKC-A; PKC-alpha; protein kinase C alpha type isoform 1; protein kinase C alpha type", "tax_id": 10116, "disease": "ductal carcinoma in situ (Disease Ontology:DOID:0060074); central conducting lymphatic anomaly (Disease Ontology:DOID:0081030); prostate carcinoma (Disease Ontology:DOID:10286); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); dilated cardiomyopathy (Disease Ontology:DOID:12930); alcohol use disorder (Disease Ontology:DOID:1574); brain ischemia (Disease Ontology:DOID:2316); ovarian cancer (Disease Ontology:DOID:2394); hemangiopericytoma (Disease Ontology:DOID:264); endometrial carcinoma (Disease Ontology:DOID:2871); cystic kidney disease (Disease Ontology:DOID:2975); high grade glioma (Disease Ontology:DOID:3070); ischemia (Disease Ontology:DOID:326); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); chordoid glioma (Disease Ontology:DOID:3774); ovarian carcinoma (Disease Ontology:DOID:4001); large cell carcinoma (Disease Ontology:DOID:4552); congestive heart failure (Disease Ontology:DOID:6000); lymphatic system disease (Disease Ontology:DOID:75)", "pathway": " (rno:24680); (R-RNO-111933); (R-RNO-114516); (R-RNO-1250196); (R-RNO-1433557); (R-RNO-1433559); (R-RNO-2179392); (R-RNO-3000170); (R-RNO-399997); (R-RNO-416993); (R-RNO-4419969); (R-RNO-450520); (R-RNO-5099900); (R-RNO-5218921); (R-RNO-5668599); (R-RNO-76005); (R-RNO-8853659)", "pathway_count": 17, "publication_count": 17, "publication_id_list": "10562545;11076962;11864993;15271671;18295358;19176525;19346474;22673903;3045562;33250241;33673008;3387228;34753065;3666147;36745530;38126185;9566962", "class_list": "", "function": "Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascades involving MAPK1/3 (ERK1/2) and RAP1GAP. Depending on the cell type, is involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation. In cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppressive form of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B. Depending on the cell type, exhibits anti-apoptotic function and protects cells from apoptosis by suppressing the p53/TP53-mediated activation of IGFBP3, or mediates anti-apoptotic action by phosphorylating BCL2. During macrophage differentiation induced by macrophage colony-stimulating factor (CSF1), is translocated to the nucleus and is associated with macrophage development. After wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion. Plays a role in cell motility by phosphorylating CSPG4, which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell accompanied by increases in cell motility. During chemokine-induced CD4(+) T cell migration, phosphorylates CDC42-guanine exchange factor DOCK8 resulting in its dissociation from LRCH1 and the activation of GTPase CDC42 (By similarity). Negatively regulates myocardial contractility and positively regulates angiogenesis, platelet aggregation and thrombus formation in arteries. Mediates hypertrophic growth of neonatal cardiomyocytes, in part through a MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is required to induce cardiomyocyte hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and cell surface area. Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial contractility. In angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN), and vascular endothelial growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube formation. Involved in the stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced cell proliferation. In the regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4 receptor for granule release, and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for adhesion. During response to lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions involved in host defense and inflammation. But in some inflammatory responses, may negatively regulate NF-kappa-B-induced genes, through IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA). Upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1 binding to MKNK1 and may be involved in the regulation of EIF4E phosphorylation. Phosphorylates KIT, leading to inhibition of KIT activity. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription (By similarity). Phosphorylates SOCS2 at 'Ser-52' facilitating its ubiquitination and proteasomal degradation (By similarity). Phosphorylates KLHL3 in response to angiotensin II signaling, decreasing the interaction between KLHL3 and WNK4 (By similarity). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Characterization of PKCalpha-rutin interactions and their application as a treatment strategy for pulmonary arterial hypertension by inhibiting ferroptosis. Publication Status: Online-Only, [RefSeq, PubMed]; Cross-Talk of Toll-Like Receptor 5 and Mu-Opioid Receptor Attenuates Chronic Constriction Injury-Induced Mechanical Hyperalgesia through a Protein Kinase C Alpha-Dependent Signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Distinct protein kinase C isoforms drive the cell cycle re-entry of two separate populations of neonatal rat ventricular cardiomyocytes., [RefSeq, PubMed]; PKCalpha mediated by the PI3K/Akt-FOXA1 cascade facilitates cypermethrin-induced hyperthyroidism., [RefSeq, PubMed]; Spatiotemporal distribution of PKCalpha, Cdc42, and Rac1 before directed cell migration., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 20, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.4.24.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.17", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.15", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.15", "type": "external" }, { "id": "2.7.11.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.16", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.1.91", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.91", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005102 signaling receptor binding;GO:0005178 integrin binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0044305 calyx of Held;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0001525 angiogenesis;GO:0001934 positive regulation of protein phosphorylation;GO:0006468 protein phosphorylation;GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P05696-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63226-1", "uniprot_id": [ { "id": "GRID2_RAT", "url": "https://www.uniprot.org/uniprot/Q63226", "type": "external" } ], "mass": 113259.0, "length": 1007, "protein_name": "Glutamate receptor ionotropic, delta-2", "gene_name": "Grid2", "organism": "Rat", "refseq_name": "glutamate receptor ionotropic, delta-2 precursor", "refseq_ac": [ { "id": "NP_077355", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077355", "type": "external" } ], "gene_names_uniprotkb": "Grid2", "gene_names_refseq": "GluD2; Grid2", "protein_names_uniprotkb": "Glutamate receptor ionotropic, delta-2; GluD2; GluR delta-2 subunit", "protein_names_refseq": "gluR delta-2 subunit; glutamate receptor delta-2 subunit; glutamate receptor ionotropic, delta-2 precursor; glutamate receptor ionotropic, delta-2", "tax_id": 10116, "disease": "autosomal recessive spinocerebellar ataxia 18 (Disease Ontology:DOID:0080042)", "pathway": " (rno:79220)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11829466;12589829;14572453;17715062;22673903;24090084;27033232;27926833;28387240;32512155;8422924", "class_list": "", "function": "Member of the ionotropic glutamate receptor family, which plays a crucial role in synaptic organization and signal transduction in the central nervous system. Although it shares structural features with ionotropic glutamate receptors, does not bind glutamate as a primary ligand. Promotes synaptogenesis and mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis of cerebellar parallel fiber-Purkinje cell (PF-PC) synapses through the NRX1B-CBLN1-GRID2 triad complex. In the presence of neurexins and cerebellins, forms cation-selective channels that are proposed to be gated by glycine and D-serine. However, recent research disputes this ligand-gated cation channel activity. Cation-selective ion channel activity can be triggered by GRM1 in Purkinje cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB, UniProtKB]; Results determined the crystal structures of the trimeric C1q-like domain of cerebellin-1, and the first complete ectodomain of GluD2. Cerebellin binds to the LNS6 domain of alpha- and beta-neurexin-1 through a high-affinity interaction that involves its highly flexible N-terminal domain., [RefSeq, PubMed]; Study supports the hypothesis that developmental hypothyroxinemia and hypothyroidism reduce PF-PC synapses, which may be attributed to the downregulation of Neurexin1/Cbln1/GluD2 tripartite complex., [RefSeq, PubMed]; The architecture of GluD2 ionotropic delta glutamate receptor elucidated by cryo-EM., [RefSeq, PubMed]; The hinge region connecting the two subdomains of the GluD2 ligand-binding domain is responsible for the low affinity of D-serine. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q62641", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0030165 PDZ domain binding;GO:0097110 scaffold protein binding;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0004971 AMPA glutamate receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0008328 ionotropic glutamate receptor complex;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043197 dendritic spine", "go_biological_process": "GO:1904861 excitatory synapse assembly;GO:0060079 excitatory postsynaptic potential;GO:0035249 synaptic transmission, glutamatergic;GO:0060134 prepulse inhibition;GO:0051965 positive regulation of synapse assembly", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q63226-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.1000000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V7R4-1", "uniprot_id": [ { "id": "FOXO1_RAT", "url": "https://www.uniprot.org/uniprot/G3V7R4", "type": "external" } ], "mass": 69344.0, "length": 649, "protein_name": "Forkhead box protein O1", "gene_name": "Foxo1", "organism": "Rat", "refseq_name": "forkhead box protein O1", "refseq_ac": [ { "id": "NP_001178775", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178775", "type": "external" } ], "gene_names_uniprotkb": "Foxo1; Foxo1a", "gene_names_refseq": "Fkhr; Foxo1a; Foxo1", "protein_names_uniprotkb": "Forkhead box protein O1; Forkhead box protein O1A; Forkhead in rhabdomyosarcoma", "protein_names_refseq": "Forkhead box protein O1A; Forkhead in rhabdomyosarcoma; forkhead box O1A (rhabdomyosarcoma); forkhead box protein O1", "tax_id": 10116, "disease": "metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); prostate cancer (Disease Ontology:DOID:10283); Parkinson's disease (Disease Ontology:DOID:14330); alveolar rhabdomyosarcoma (Disease Ontology:DOID:4051); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:84482); (R-RNO-198693); (R-RNO-211163); (R-RNO-5687128); (R-RNO-9614399); (R-RNO-9617629); (R-RNO-9617828)", "pathway_count": 7, "publication_count": 13, "publication_id_list": "12891709;17433823;19483080;22673903;24174424;26436652;29393594;38149787;38189995;38358361;38518842;38943142;41028781", "class_list": "", "function": "EGF-driven EGFR/miR-27b-3p/FOXO1 promotes rat FSH synthesis and secretion., [RefSeq, PubMed]; Effects of resistance training on alleviating hypoxia-induced muscle atrophy: Focus on acetylation of FoxO1., [RefSeq, PubMed]; Inhibition of FoxO1 alleviates polycystic ovarian syndrome by reducing inflammation and the immune response. Publication Status: Online-Only, [RefSeq, PubMed]; Silencing of forkhead box protein O-1 (FOXO-1) enhances insulin-producing cell generation from adipose mesenchymal stem cells for diabetes therapy., [RefSeq, PubMed]; Tissue factor regulates autophagy in pulmonary artery endothelial cells from chronic thromboembolic pulmonary hypertension rats via the p38 MAPK-FoxO1 pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress (By similarity). Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin (By similarity). Main regulator of redox balance and osteoblast numbers and controls bone mass (By similarity). Orchestrates the endocrine function of the skeleton in regulating glucose metabolism (By similarity). Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity (By similarity). Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP (By similarity). Acts as an inhibitor of glucose sensing in pancreatic beta cells by acting as a transcription repressor and suppressing expression of PDX1 (By similarity). In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC1 and PCK1 (By similarity). Also promotes gluconeogenesis by directly promoting expression of PPARGC1A and G6PC1 (By similarity). Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and STK4/MST1 (By similarity). Promotes neural cell death (By similarity). Mediates insulin action on adipose tissue (By similarity). Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake (By similarity). Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells (By similarity). Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner (By similarity). Mediates the function of MLIP in cardiomyocytes hypertrophy and cardiac remodeling (PubMed:26436652). Positive regulator of apoptosis in cardiac smooth muscle cells as a result of its transcriptional activation of pro-apoptotic genes (PubMed:19483080). Regulates endothelial cell (EC) viability and apoptosis in a PPIA/CYPA-dependent manner via transcription of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0031625 ubiquitin protein ligase binding;GO:0003676 nucleic acid binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010629 negative regulation of gene expression;GO:0030154 cell differentiation;GO:0032869 cellular response to insulin stimulus", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "G3V7R4-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35165-1", "uniprot_id": [ { "id": "GOSR2_RAT", "url": "https://www.uniprot.org/uniprot/O35165", "type": "external" } ], "mass": 24607.0, "length": 212, "protein_name": "Golgi SNAP receptor complex member 2", "gene_name": "Gosr2", "organism": "Rat", "refseq_name": "Golgi SNAP receptor complex member 2", "refseq_ac": [ { "id": "NP_113873", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113873", "type": "external" } ], "gene_names_uniprotkb": "Gosr2; Gs27", "gene_names_refseq": "Gosr2", "protein_names_uniprotkb": "Golgi SNAP receptor complex member 2; 27 kDa Golgi SNARE protein; Membrin", "protein_names_refseq": "27 kDa Golgi SNARE protein; Golgi SNAP receptor complex member 2; membrin", "tax_id": 10116, "disease": "progressive myoclonus epilepsy 6 (Disease Ontology:DOID:0111449); progressive myoclonus epilepsy (Disease Ontology:DOID:891)", "pathway": " (rno:64154); (R-RNO-204005); (R-RNO-5694530); (R-RNO-6807878); (R-RNO-6811438)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "11323436;14742712;9094723;9349823", "class_list": "", "function": "Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O08566;Q6GSW2", "ec_number_list": [], "go_molecular_function": "GO:0000149 SNARE binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane;GO:0031902 late endosome membrane;GO:0012507 ER to Golgi transport vesicle membrane", "go_biological_process": "GO:0015031 protein transport;GO:0016192 vesicle-mediated transport;GO:0006906 vesicle fusion;GO:0006891 intra-Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O35165-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02688-1", "uniprot_id": [ { "id": "MBP_RAT", "url": "https://www.uniprot.org/uniprot/P02688", "type": "external" } ], "mass": 21502.0, "length": 195, "protein_name": "Myelin basic protein", "gene_name": "Mbp", "organism": "Rat", "refseq_name": "myelin basic protein isoform 1", "refseq_ac": [ { "id": "NP_001020462", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020462", "type": "external" } ], "gene_names_uniprotkb": "Mbp", "gene_names_refseq": "Mbps; Mbp", "protein_names_uniprotkb": "Myelin basic protein; MBP", "protein_names_refseq": "Golli-Mbp; MBP S; myelin basic protein Golli-mbp; myelin basic protein S; myelin basic protein isoform 1", "tax_id": 10116, "disease": "osteoporosis (Disease Ontology:DOID:11476); Huntington's disease (Disease Ontology:DOID:12858); periventricular leukomalacia (Disease Ontology:DOID:13088); hypothyroidism (Disease Ontology:DOID:1459); transient cerebral ischemia (Disease Ontology:DOID:224); multiple sclerosis (Disease Ontology:DOID:2377); demyelinating disease (Disease Ontology:DOID:3213); temporal lobe epilepsy (Disease Ontology:DOID:3328); periodontal disease (Disease Ontology:DOID:3388); dentinogenesis imperfecta (Disease Ontology:DOID:4154); schizophrenia (Disease Ontology:DOID:5419); encephalitis (Disease Ontology:DOID:9588); diabetic neuropathy (Disease Ontology:DOID:9743)", "pathway": " (rno:24547)", "pathway_count": 1, "publication_count": 29, "publication_id_list": "12756272;14580679;21112354;22673903;2425097;2429678;2430104;2431317;2456304;2460551;2471778;2474052;2480602;28889362;29073112;29742816;30926549;31885393;4122324;4141893;6194889;7537302;7563242;7578863;7593553;7693759;8759768;8892082;9590272", "class_list": "", "function": "A role for the retrograde dynein/dynactin motor complex in anterograde mbp mRNA transport., [RefSeq, PubMed]; All pups with exposure to methadone demonstrated decreased expression of MBP in the cerebral cortex and hippocampus.In the cerebellum, PLP expression was downregulated without apparent alteration of CNP and MBP expression. PLP and MBP expression, but not CNP expression, were significantly inhibited in the brainstem., [RefSeq, PubMed]; Angiostrongylus cantonensis-conditioned culture medium induced suppression of the Erk1/2-NF-kappaB signaling pathway leading to reduced MBP production in RSC96 Schwann cells., [RefSeq, PubMed]; Gonadectomy prior to puberty onset resulted in a significant reduction of myelin basic protein levels in the orbitofrontal cortex in females but not males., [RefSeq, PubMed]; Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity)., [UniProtKB]; The protein encoded by the classic Mbp gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, Mbp-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long Mbp gene (otherwise called 'Golli-Mbp') that contains 3 additional exons located upstream of the classic Mbp exons. Alternative splicing from the Golli and the Mbp transcription start sites gives rise to 2 sets of Mbp-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-Mbp, spliced in-frame to 1 or more Mbp exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to Mbp aa sequence. The second family of transcripts contain only Mbp exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the Mbp transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. Mutation of the Mbp gene is associated with the 'shiverer' and 'myelin deficient' phenotypes in mouse. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q505J1;Q8R4K6;Q9Z1J4;Q9Z1J5;Q9Z1J6", "ec_number_list": [], "go_molecular_function": "GO:0019911 structural constituent of myelin sheath;GO:0002020 protease binding;GO:0005516 calmodulin binding;GO:0017124 SH3 domain binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0033269 internode region of axon;GO:0009986 cell surface;GO:0043025 neuronal cell body;GO:0043209 myelin sheath;GO:0071944 cell periphery", "go_biological_process": "GO:0034612 response to tumor necrosis factor;GO:0042552 myelination;GO:0061024 membrane organization;GO:0032570 response to progesterone;GO:0009636 response to toxic substance", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P02688-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62813-1", "uniprot_id": [ { "id": "GBRA1_RAT", "url": "https://www.uniprot.org/uniprot/P62813", "type": "external" } ], "mass": 51754.0, "length": 455, "protein_name": "Gamma-aminobutyric acid receptor subunit alpha-1", "gene_name": "Gabra1", "organism": "Rat", "refseq_name": "gamma-aminobutyric acid receptor subunit alpha-1 precursor", "refseq_ac": [ { "id": "NP_899155", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_899155", "type": "external" } ], "gene_names_uniprotkb": "Gabra1; Gabra-1", "gene_names_refseq": "Gabra1", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit alpha-1; GABA(A) receptor subunit alpha-1; GABAAR subunit alpha-1", "protein_names_refseq": "GABA(A) receptor subunit alpha-1; GABAAR subunit alpha-1; gamma-aminobutyric acid (GABA) A receptor, alpha 1; gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 1; gamma-aminobutyric acid A receptor, alpha 1; gamma-aminobutyric acid receptor subunit alpha-1 precursor; gamma-aminobutyric acid receptor subunit alpha-1; gamma-aminobutyric acid type A receptor alpha1 subunit", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 19 (Disease Ontology:DOID:0080431); hepatic encephalopathy (Disease Ontology:DOID:13413); generalized epilepsy (Disease Ontology:DOID:1827); epilepsy with generalized tonic-clonic seizures (Disease Ontology:DOID:7725)", "pathway": " (rno:29705); (R-RNO-977443)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "11528422;1376242;17003036;18281286;1966765;1977069;25172774;2540033;2561977;28279354;30044221;32875348;33636639;33958479;34029007;34064454;38843836;9464994;9882711", "class_list": "", "function": "Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:1376242, PubMed:1977069, PubMed:2540033, PubMed:9882711). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (PubMed:30044221). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:18281286, PubMed:1977069, PubMed:9882711). Alpha-1/GABRA1-containing GABAARs are largely synaptic (PubMed:9464994). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (PubMed:18281286, PubMed:1977069). GABAARs containing alpha-1 and beta-2 or -3 subunits exhibit synaptogenic activity; the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation (By similarity). GABAARs function also as histamine receptor where histamine binds at the interface of two neighboring beta subunits and potentiates GABA response (PubMed:18281286, PubMed:1977069). GABAARs containing alpha, beta and epsilon subunits also permit spontaneous chloride channel activity while preserving the structural information required for GABA-gated openings (PubMed:9882711). Alpha-1-mediated plasticity in the orbitofrontal cortex regulates context-dependent action selection (By similarity). Together with rho subunits, may also control neuronal and glial GABAergic transmission in the cerebellum (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Characterization of the Functional Cross-Talk between Surface GABAA and Dopamine D5 Receptors. Publication Status: Online-Only, [RefSeq, PubMed]; Inhibition of microRNA-129-2-3p protects against refractory temporal lobe epilepsy by regulating GABRA1., [RefSeq, PubMed]; Intrasubunit and Intersubunit Steroid Binding Sites Independently and Additively Mediate alpha1beta2gamma2L GABAA Receptor Potentiation by the Endogenous Neurosteroid Allopregnanolone., [RefSeq, PubMed]; Role of the GABAa and GABAb receptors of the central nucleus of the amygdala in compulsive cocaine-seeking behavior in male rats., [RefSeq, PubMed]; Stimulation of brain alpha7-nicotinic acetylcholine receptors suppresses the rat micturition through brain GABAergic receptors., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 4, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "P18504;Q53YK4", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0050809 diazepam binding;GO:0004890 GABA-A receptor activity;GO:0022851 GABA-gated chloride ion channel activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0043197 dendritic spine;GO:0030659 cytoplasmic vesicle membrane;GO:0098794 postsynapse", "go_biological_process": "GO:0007214 gamma-aminobutyric acid signaling pathway;GO:0010996 response to auditory stimulus;GO:1902476 chloride transmembrane transport;GO:0071420 cellular response to histamine;GO:0051932 synaptic transmission, GABAergic", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P62813-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97577-1", "uniprot_id": [ { "id": "FEZ1_RAT", "url": "https://www.uniprot.org/uniprot/P97577", "type": "external" } ], "mass": 45244.0, "length": 393, "protein_name": "Fasciculation and elongation protein zeta-1", "gene_name": "Fez1", "organism": "Rat", "refseq_name": "fasciculation and elongation protein zeta-1", "refseq_ac": [ { "id": "NP_112328", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112328", "type": "external" } ], "gene_names_uniprotkb": "Fez1", "gene_names_refseq": "Fez1", "protein_names_uniprotkb": "Fasciculation and elongation protein zeta-1; Zygin I; Zygin-1", "protein_names_refseq": "fasciculation and elongation protein zeta-1; protein kinase C-binding protein Zeta1; zygin I; zygin-1", "tax_id": 10116, "disease": "Jacobsen Syndrome (Disease Ontology:DOID:0111723); Parkinson's disease (Disease Ontology:DOID:14330); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:81730)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "12874605;14992819;15466860;17173861;17669366;22673903;27247180;31774489;33395696;33771901;9971736", "class_list": "", "function": "DISC1 participates in neurite outgrowth through its interaction with FEZ1., [RefSeq, PubMed]; E4B serves as a ubiquitin ligase for FEZ1 and thereby regulates its function but not its degradation, [RefSeq, PubMed]; FEZ1 Forms Complexes with CRMP1 and DCC to Regulate Axon and Dendrite Development. Publication Status: Online-Only, [RefSeq, PubMed]; FEZ1 showed high levels of expression, especially in developing hippocampal neurons., [RefSeq, PubMed]; Loss of FEZ1, a gene deleted in Jacobsen syndrome, causes locomotion defects and early mortality by impairing motor neuron development., [RefSeq, PubMed]; May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. May participate in the transport of mitochondria and other cargos along microtubules., [UniProtKB, PubMed, PubMed]; Phosphorylation of FEZ1 by MARK regulates its function in presynaptic protein trafficking. Publication Status: Online-Only, [RefSeq, PubMed]; Results indicate that astrocytic FEZ1 and glutamate-glutamine cycle dysfunction may be involved in the pathogenesis of depression after frontal lobe injury., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q62922", "ec_number_list": [], "go_molecular_function": "GO:0005080 protein kinase C binding;GO:0043015 gamma-tubulin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005874 microtubule;GO:0005886 plasma membrane", "go_biological_process": "GO:1902902 negative regulation of autophagosome assembly;GO:0010976 positive regulation of neuron projection development;GO:0021766 hippocampus development;GO:0071363 cellular response to growth factor stimulus;GO:0007005 mitochondrion organization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P97577-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06496-1", "uniprot_id": [ { "id": "NPT2A_RAT", "url": "https://www.uniprot.org/uniprot/Q06496", "type": "external" } ], "mass": 68707.0, "length": 637, "protein_name": "Sodium-dependent phosphate transport protein 2A", "gene_name": "Slc34a1", "organism": "Rat", "refseq_name": "sodium-dependent phosphate transport protein 2A", "refseq_ac": [ { "id": "NP_037162", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037162", "type": "external" } ], "gene_names_uniprotkb": "Slc34a1; Slc17a2", "gene_names_refseq": "NaPi-2; NaPi2A; Npt2; Slc17a2; Slc34a1", "protein_names_uniprotkb": "Sodium-dependent phosphate transport protein 2A; Na(+)-dependent phosphate cotransporter 2A; Na(+)/Pi cotransporter 2A; NaPi-2a; Sodium-phosphate transport protein 2A; Sodium/phosphate cotransporter 2A; Solute carrier family 34 member 1", "protein_names_refseq": "Na(+)-dependent phosphate cotransporter 2A; Na(+)/Pi cotransporter 2A; naPi-2a; sodium-dependent phosphate transport protein 2A; sodium-phosphate co-transporter type II; sodium-phosphate transport protein 2A; sodium/phosphate cotransporter 2A; solute carrier family 17 (sodium/hydrogen exchanger) member 2; solute carrier family 34 (sodium phosphate), member 1; solute carrier family 34 (type II sodium/phosphate cotransporter), member 1", "tax_id": 10116, "disease": "hypophosphatemia (Disease Ontology:DOID:0050336); hereditary hypophosphatemic rickets with hypercalciuria (Disease Ontology:DOID:0050947); infantile hypercalcemia 2 (Disease Ontology:DOID:0061135); hypophosphatemic nephrolithiasis/osteoporosis 1 (Disease Ontology:DOID:0080077); Fanconi renotubular syndrome 2 (Disease Ontology:DOID:0080758); Fanconi syndrome (Disease Ontology:DOID:1062); urinary bladder cancer (Disease Ontology:DOID:11054); hypothyroidism (Disease Ontology:DOID:1459); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); ovarian carcinoma (Disease Ontology:DOID:4001); nephrolithiasis (Disease Ontology:DOID:585); pancreatic intraductal papillary-mucinous neoplasm (Disease Ontology:DOID:7575); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784); hyperthyroidism (Disease Ontology:DOID:7998); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898)", "pathway": " (rno:25548); (R-RNO-427589); (R-RNO-5683826)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10198426;10370077;10926678;22673903;26460967;26782594;30696771;32853180;7929070;8327470;8691716;9058191;9163330", "class_list": "", "function": "Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane (PubMed:10198426, PubMed:10370077, PubMed:10926678, PubMed:8327470, PubMed:9058191). The cotransport has a Na(+):Pi stoichiometry of 3:1 and is electrogenic (PubMed:10198426)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Multiprotein kinase cascade involving G protein-coupled receptor kinase 6A controls the Ser(290) phosphorylation status of NHERF1 and regulates PTH-sensitive, NPT2A-mediated phosphate uptake, [RefSeq, PubMed]; NaPi-IIa mRNA expression is affected by hyperphosphatemia. Publication Status: Online-Only, [RefSeq, PubMed]; Napi2a, a renal cotransporter for Pi reabsorption, accumulated on plasma membranes in a vitamin B12 deficiency suggests that vitamin B12 plays an important role in Pi homeostasis, [RefSeq, PubMed]; Selective pharmacological inhibition of the sodium-dependent phosphate cotransporter NPT2a promotes phosphate excretion., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 2, "mined_n_glycosites": 2, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 12, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0030165 PDZ domain binding;GO:0005436 sodium:phosphate symporter activity", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0005903 brush border;GO:0009986 cell surface;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0097187 dentinogenesis;GO:1904383 response to sodium phosphate;GO:0007584 response to nutrient;GO:0010288 response to lead ion;GO:0001822 kidney development", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q06496-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.1000100001001.111.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q498T9-1", "uniprot_id": [ { "id": "LRC8C_RAT", "url": "https://www.uniprot.org/uniprot/Q498T9", "type": "external" } ], "mass": 92463.0, "length": 803, "protein_name": "Volume-regulated anion channel subunit LRRC8C", "gene_name": "Lrrc8c", "organism": "Rat", "refseq_name": "volume-regulated anion channel subunit LRRC8C", "refseq_ac": [ { "id": "NP_001032256", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032256", "type": "external" } ], "gene_names_uniprotkb": "Lrrc8c", "gene_names_refseq": "Lrrc8c; RGD1306585", "protein_names_uniprotkb": "Volume-regulated anion channel subunit LRRC8C; Leucine-rich repeat-containing protein 8C", "protein_names_refseq": "leucine rich repeat containing 8 family, member C; leucine-rich repeat-containing protein 8C; volume-regulated anion channel subunit LRRC8C", "tax_id": 10116, "disease": "", "pathway": " (rno:289443); (R-RNO-5223345)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22673903;28833202", "class_list": "", "function": "Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:28833202). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (By similarity). Plays a redundant role in the efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress (By similarity). The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (By similarity). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:28833202)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0005225 volume-sensitive anion channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0098656 monoatomic anion transmembrane transport;GO:0045444 fat cell differentiation;GO:0015734 taurine transmembrane transport;GO:0071470 cellular response to osmotic stress;GO:0034214 protein hexamerization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q498T9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q566R4-1", "uniprot_id": [ { "id": "LRA25_RAT", "url": "https://www.uniprot.org/uniprot/Q566R4", "type": "external" } ], "mass": 20169.0, "length": 189, "protein_name": "Leucine repeat adapter protein 25", "gene_name": "Fam89b", "organism": "Rat", "refseq_name": "leucine repeat adapter protein 25", "refseq_ac": [ { "id": "NP_001015013", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015013", "type": "external" } ], "gene_names_uniprotkb": "Fam89b; Lrap25; Mtvr2", "gene_names_refseq": "Fam89b; Mtvr2", "protein_names_uniprotkb": "Leucine repeat adapter protein 25; Mammary tumor virus receptor 2", "protein_names_refseq": "leucine repeat adapter protein 25; mammary tumor virus receptor 2; protein FAM89B", "tax_id": 10116, "disease": "", "pathway": " (rno:309170)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "25107909", "class_list": "", "function": "Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation., [UniProtKB, UniProtKB]; The functional relevance of the LRAP25-MRCK complex in LIMK1-cofilin signaling and the importance of LRAP adaptors as key determinants of MRCK cellular localization and downstream specificities., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001222 transcription corepressor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030027 lamellipodium", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway;GO:0030010 establishment of cell polarity;GO:0060392 negative regulation of SMAD protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q566R4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62685-1", "uniprot_id": [ { "id": "NR1H3_RAT", "url": "https://www.uniprot.org/uniprot/Q62685", "type": "external" } ], "mass": 50555.0, "length": 445, "protein_name": "Oxysterols receptor LXR-alpha", "gene_name": "Nr1h3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Nr1h3; Lxra", "gene_names_refseq": "", "protein_names_uniprotkb": "Oxysterols receptor LXR-alpha; Liver X receptor alpha; Nuclear receptor subfamily 1 group H member 3; RLD-1", "protein_names_refseq": "", "tax_id": 10116, "disease": "metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); pre-eclampsia (Disease Ontology:DOID:10591); carotid stenosis (Disease Ontology:DOID:13001); atherosclerosis (Disease Ontology:DOID:1936); coronary artery disease (Disease Ontology:DOID:3393); cerebral infarction (Disease Ontology:DOID:3526); ovarian hyperstimulation syndrome (Disease Ontology:DOID:5425); myocardial infarction (Disease Ontology:DOID:5844); cerebrovascular disease (Disease Ontology:DOID:6713); abdominal aortic aneurysm (Disease Ontology:DOID:7693); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:58852); (R-RNO-383280); (R-RNO-4090294); (R-RNO-8866427); (R-RNO-9029569); (R-RNO-9623433)", "pathway_count": 6, "publication_count": 2, "publication_id_list": "22673903;7935418", "class_list": "", "function": "Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis (By similarity). Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles (By similarity). Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0003707 nuclear steroid receptor activity;GO:0044877 protein-containing complex binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0043235 receptor complex;GO:0000785 chromatin", "go_biological_process": "GO:0048550 negative regulation of pinocytosis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001889 liver development;GO:0006629 lipid metabolic process;GO:0010875 positive regulation of cholesterol efflux", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q62685-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62881-1", "uniprot_id": [ { "id": "NOL3_RAT", "url": "https://www.uniprot.org/uniprot/Q62881", "type": "external" } ], "mass": 24577.0, "length": 221, "protein_name": "Nucleolar protein 3", "gene_name": "Nol3", "organism": "Rat", "refseq_name": "nucleolar protein 3 isoform 3", "refseq_ac": [ { "id": "NP_445968", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445968", "type": "external" } ], "gene_names_uniprotkb": "Nol3; Arc", "gene_names_refseq": "Arc; Nol3", "protein_names_uniprotkb": "Nucleolar protein 3; Apoptosis repressor with CARD", "protein_names_refseq": "apoptosis repressor with CARD; nucleolar protein 3 (apoptosis repressor with CARD domain); nucleolar protein 3 isoform 3", "tax_id": 10116, "disease": "", "pathway": " (rno:85383)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10590251;10644725;12191471;15383280;16639714;17142834;17292893;17998337;19001025;22082675;22673903;23382383;28731195;31257698;31587299;8634331", "class_list": "", "function": "Apoptosis repressor that blocks multiple modes of cell death. Inhibits extrinsic apoptotic pathways through two different ways. Firstly by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex (DISC) assembly (PubMed:15383280). Secondly by interacting with CASP8 in a mitochondria localization- and phosphorylation-dependent manner, limiting the amount of soluble CASP8 available for DISC-mediated activation (PubMed:12191471). Inhibits intrinsic apoptotic pathway in response to a wide range of stresses, through its interaction with BAX resulting in BAX inactivation, preventing mitochondrial dysfunction and release of pro-apoptotic factors (PubMed:15383280). Inhibits calcium-mediated cell death by functioning as a cytosolic calcium buffer, dissociating its interaction with CASP8 and maintaining calcium homeostasis (PubMed:23382383). Negatively regulates oxidative stress-induced apoptosis by phosphorylation-dependent suppression of the mitochondria-mediated intrinsic pathway, by blocking CASP2 activation and BAX translocation (PubMed:16639714). Negatively regulates hypoxia-induced apoptosis in part by inhibiting the release of cytochrome c from mitochondria in a caspase-independent manner (PubMed:10590251). Also inhibits TNF-induced necrosis by preventing TNF-signaling pathway through TNFRSF1A interaction abrogating the recruitment of RIPK1 to complex I (By similarity). Finally through its role as apoptosis repressor, promotes vascular remodeling through inhibition of apoptosis and stimulation of proliferation, in response to hypoxia (By similarity). Inhibits too myoblast differentiation through caspase inhibition (PubMed:17292893)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Inhibition of microRNA-327 ameliorates ischemia/reperfusion injury-induced cardiomyocytes apoptosis through targeting apoptosis repressor with caspase recruitment domain., [RefSeq, PubMed]; Loss of nuclear ARC contributes to the development of cardiac hypertrophy in rats., [RefSeq, PubMed]; The results of the present study revealed that ARC inhibition promotes the apoptosis of pulmonary arterial smooth muscle cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0019900 kinase binding;GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0051562 negative regulation of mitochondrial calcium ion concentration;GO:0002931 response to ischemia;GO:0043066 negative regulation of apoptotic process;GO:0051259 protein complex oligomerization;GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q62881-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66HG4-1", "uniprot_id": [ { "id": "GALM_RAT", "url": "https://www.uniprot.org/uniprot/Q66HG4", "type": "external" } ], "mass": 37893.0, "length": 342, "protein_name": "Galactose mutarotase", "gene_name": "Galm", "organism": "Rat", "refseq_name": "galactose mutarotase", "refseq_ac": [ { "id": "NP_001007705", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007705", "type": "external" } ], "gene_names_uniprotkb": "Galm", "gene_names_refseq": "Galm", "protein_names_uniprotkb": "Galactose mutarotase; 5.1.3.3; Aldose 1-epimerase", "protein_names_refseq": "aldose 1-epimerase; galactose mutarotase", "tax_id": 10116, "disease": "galactosemia 4 (Disease Ontology:DOID:0060969)", "pathway": " (rno:313843); (R-RNO-70370)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase). Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1. Also active on D-glucose although shows a preference for galactose over glucose., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.1.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.3", "type": "external" } ], "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0004034 aldose 1-epimerase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0006006 glucose metabolic process;GO:0033499 galactose catabolic process via UDP-galactose, Leloir pathway;GO:0006012 galactose metabolic process;GO:0019318 hexose metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q66HG4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68G30-1", "uniprot_id": [ { "id": "KLC3_RAT", "url": "https://www.uniprot.org/uniprot/Q68G30", "type": "external" } ], "mass": 55655.0, "length": 505, "protein_name": "Kinesin light chain 3", "gene_name": "Klc3", "organism": "Rat", "refseq_name": "kinesin light chain 3", "refseq_ac": [ { "id": "NP_612529", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612529", "type": "external" } ], "gene_names_uniprotkb": "Klc3", "gene_names_refseq": "Klc3; Klct", "protein_names_uniprotkb": "Kinesin light chain 3; Kinesin light chain KLCt", "protein_names_refseq": "kinesin light chain 3; kinesin light chain KLCt", "tax_id": 10116, "disease": "Alzheimer's disease 1 (Disease Ontology:DOID:0080348)", "pathway": " (rno:171549); (R-RNO-2132295); (R-RNO-5625970); (R-RNO-6811434); (R-RNO-983189)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "11319135;12594206;15464570", "class_list": "", "function": "Can associate with mitochondria., [RefSeq, PubMed]; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Plays a role during spermiogenesis in the development of the sperm tail midpiece and in the normal function of spermatozoa (By similarity). May play a role in the formation of the mitochondrial sheath formation in the developing spermatid midpiece (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9ESH7", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0019894 kinesin binding;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005874 microtubule;GO:0031514 motile cilium;GO:0035253 ciliary rootlet", "go_biological_process": "GO:0007283 spermatogenesis;GO:0008088 axo-dendritic transport;GO:0007286 spermatid development;GO:0007018 microtubule-based movement;GO:0120317 sperm mitochondrial sheath assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q68G30-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYD6-1", "uniprot_id": [ { "id": "PDLI2_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYD6", "type": "external" } ], "mass": 37580.0, "length": 349, "protein_name": "PDZ and LIM domain protein 2", "gene_name": "Pdlim2", "organism": "Rat", "refseq_name": "PDZ and LIM domain protein 2", "refseq_ac": [ { "id": "NP_001007623", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007623", "type": "external" } ], "gene_names_uniprotkb": "Pdlim2", "gene_names_refseq": "Pdlim2", "protein_names_uniprotkb": "PDZ and LIM domain protein 2", "protein_names_refseq": "PDZ and LIM domain protein 2; alpha-actinins and filamin-interacting protein", "tax_id": 10116, "disease": "", "pathway": " (rno:290354)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15505042;22673903", "class_list": "", "function": "Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051371 muscle alpha-actinin binding;GO:0003779 actin binding;GO:0046872 metal ion binding;GO:0031625 ubiquitin protein ligase binding;GO:0051393 alpha-actinin binding", "go_cellular_component": "GO:0005912 adherens junction;GO:0005925 focal adhesion;GO:0015629 actin cytoskeleton;GO:0001725 stress fiber;GO:0030018 Z disc", "go_biological_process": "GO:0007507 heart development;GO:0030036 actin cytoskeleton organization;GO:0030163 protein catabolic process;GO:0061061 muscle structure development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6AYD6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P791-1", "uniprot_id": [ { "id": "LTOR1_RAT", "url": "https://www.uniprot.org/uniprot/Q6P791", "type": "external" } ], "mass": 17721.0, "length": 161, "protein_name": "Ragulator complex protein LAMTOR1", "gene_name": "Lamtor1l1; Lamtor1", "organism": "Rat", "refseq_name": "ragulator complex protein LAMTOR1", "refseq_ac": [ { "id": "NP_954533", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_954533", "type": "external" } ], "gene_names_uniprotkb": "Lamtor1l1; Lamtor1; LOC100361543; Lamtor1l1; Lamtor1", "gene_names_refseq": "Lamtor1; p18", "protein_names_uniprotkb": "Ragulator complex protein LAMTOR1; Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1; Lipid raft adaptor protein p18", "protein_names_refseq": "RhoA activator C11orf59 homolog; late endosomal/lysosomal adaptor and MAPK and MTOR activator 1; lipid raft adaptor protein p18; p27Kip1-releasing factor from RhoA; p27RF-Rho; ragulator complex protein LAMTOR1", "tax_id": 10116, "disease": "", "pathway": " (rno:308869); (R-RNO-1632852); (R-RNO-165159); (R-RNO-166208); (R-RNO-380972); (R-RNO-5628897); (R-RNO-6798695); (R-RNO-8943724); (R-RNO-9013149); (R-RNO-9013404); (R-RNO-9013406); (R-RNO-9013407); (R-RNO-9013408); (R-RNO-9013423); (R-RNO-9639288)", "pathway_count": 15, "publication_count": 4, "publication_id_list": "19177150;20510017;22673903;26254426", "class_list": "", "function": "Key component of the Ragulator complex, a multiprotein complex involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to the lysosomal membrane. LAMTOR1 wraps around the other subunits of the Ragulator complex to hold them in place and interacts with the Rag GTPases, thereby playing a key role in the recruitment of the mTORC1 complex to lysosomes (By similarity). Also involved in the control of embryonic stem cells differentiation via non-canonical RagC/RRAGC and RagD/RRAGD activation: together with FLCN, it is necessary to recruit and activate RagC/RRAGC and RagD/RRAGD at the lysosomes, and to induce exit of embryonic stem cells from pluripotency via non-canonical, mTOR-independent TFE3 inactivation (By similarity). Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; P18 is an endosomal membrane-anchored protein that interacts with the p14/MP1 ERK scaffold protein., [RefSeq, PubMed]; Study suggest that PEBP and C11orf59 might be involved in controlling lipid or carbohydrate metabolism in diabetes via PPARalpha activation., [RefSeq, PubMed]; This study shows for the first time that neovascularization within the pulmonary vasculature is dependent on the prorecycling endocytic proteins Rab4 and p18., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051020 GTPase binding;GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0045121 membrane raft;GO:0005764 lysosome;GO:0005765 lysosomal membrane", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0043410 positive regulation of MAPK cascade;GO:0001919 regulation of receptor recycling;GO:0042632 cholesterol homeostasis;GO:0001558 regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6P791-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JM59-1", "uniprot_id": [ { "id": "KCIP2_RAT", "url": "https://www.uniprot.org/uniprot/Q9JM59", "type": "external" } ], "mass": 30933.0, "length": 270, "protein_name": "A-type potassium channel modulatory protein KCNIP2", "gene_name": "Kcnip2", "organism": "Rat", "refseq_name": "A-type potassium channel modulatory protein KCNIP2 isoform c", "refseq_ac": [ { "id": "NP_001029133", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029133", "type": "external" } ], "gene_names_uniprotkb": "Kcnip2; Kchip2", "gene_names_refseq": "Kchip2; Kcnip2", "protein_names_uniprotkb": "A-type potassium channel modulatory protein KCNIP2; KChIP2; Kv channel-interacting protein 2; Potassium channel-interacting protein 2", "protein_names_refseq": "A-type potassium channel modulatory protein 2; A-type potassium channel modulatory protein KCNIP2 isoform c; A-type potassium channel modulatory protein KCNIP2; Kv channel-interacting protein 2-like; Kv channel-interacting protein 2; potassium channel auxiliary subunit KCHIP2", "tax_id": 10116, "disease": "", "pathway": " (rno:56817); (R-RNO-5576894)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10676964;11263977;12006572;12646414;16820361;22673903;24486512;24793047;26742842;30760025;31362018", "class_list": "", "function": "Acute stress in a rat model of cardiac arrest/resuscitation induced changes in native KChIP2 resembling those of KChIP2 depalmitoylation, promoting KChIP2 nuclear entry., [RefSeq, PubMed]; MRNA and KChIP2 promoter data suggest that the ISO-induced Ito,f reductions are, in part, mediated through reduced KChIP2 transcription caused by NF-kappaB activation., [RefSeq, PubMed]; Palmitoylation of the KChIP auxiliary subunits controls plasma membrane localization of their associated channels, [RefSeq, PubMed]; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels (PubMed:10676964, PubMed:16820361). Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner (PubMed:10676964, PubMed:16820361). Involved in KCND2 and KCND3 trafficking to the cell surface (By similarity). Essential for the expression of I(To) currents in the heart (By similarity). Required for normal protein levels of KCND2 in the heart ventricle (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; These findings establish MG53 as a novel regulator of KChIP2 and Ito,f by modulating NF-kappaB activity and reveal its critical role in electrophysiological remodeling in cardiac hypertrophy., [RefSeq, PubMed]; Type 2 diabetes induces Endo-predominant prolongation of the action potential duration via a reduction of the fast component of Ito recovery from inactivation and reduced steady-state Ito, in which downregulation of Kv4.2 and KChIP2 may be involved., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JI21;Q9JI22;Q9JI23;Q9JM60", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0015459 potassium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0005509 calcium ion binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0008076 voltage-gated potassium channel complex;GO:0071193 Kv4.2-KChIP2 channel complex", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0006936 muscle contraction;GO:0001508 action potential;GO:0060306 regulation of membrane repolarization;GO:0009966 regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9JM59-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1W6-1", "uniprot_id": [ { "id": "LYRIC_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z1W6", "type": "external" } ], "mass": 63969.0, "length": 581, "protein_name": "Protein LYRIC", "gene_name": "Mtdh", "organism": "Rat", "refseq_name": "protein LYRIC isoform 1", "refseq_ac": [ { "id": "NP_596889", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_596889", "type": "external" } ], "gene_names_uniprotkb": "Mtdh; Lyric", "gene_names_refseq": "Lyric; Mtdh", "protein_names_uniprotkb": "Protein LYRIC; Lysine-rich CEACAM1 co-isolated protein; Metadherin; Metastasis adhesion protein", "protein_names_refseq": "lysine-rich CEACAM1 co-isolated protein; metastasis adhesion protein; protein LYRIC isoform 1; protein LYRIC", "tax_id": 10116, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:170910)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15383321;22673903;27351433;35195734", "class_list": "", "function": "AEG-1 was expressed mainly in Schwann cells of the distal sciatic nerve segment from injury. Interference of AEG-1 inhibited both proliferation and migration of Schwann cells., [RefSeq, PubMed]; Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance (By similarity)., [UniProtKB]; Microparticles from Hyperphosphatemia-Stimulated Endothelial Cells Promote Vascular Calcification Through Astrocyte-Elevated Gene-1., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0051059 NF-kappaB binding;GO:0003725 double-stranded RNA binding;GO:0003712 transcription coregulator activity;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005923 bicellular tight junction", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0043066 negative regulation of apoptotic process;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0045766 positive regulation of angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9Z1W6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53565-1", "uniprot_id": [ { "id": "CUX1_RAT", "url": "https://www.uniprot.org/uniprot/P53565", "type": "external" } ], "mass": 164541.0, "length": 1504, "protein_name": "Homeobox protein cut-like 1", "gene_name": "Cux1", "organism": "Rat", "refseq_name": "homeobox protein cut-like 1 isoform 1", "refseq_ac": [ { "id": "NP_446312", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446312", "type": "external" } ], "gene_names_uniprotkb": "Cux1; Cdpl1; Cutl1", "gene_names_refseq": "CDP2; CDP; Cutl1; Cux1", "protein_names_uniprotkb": "Homeobox protein cut-like 1; CCAAT displacement protein; CDP2; CDP; Homeobox protein cux-1", "protein_names_refseq": "CCAAT displacement protein; homeobox protein cut-like 1 isoform 1; homeobox protein cut-like 1; homeobox protein cux-1", "tax_id": 10116, "disease": "stomach cancer (Disease Ontology:DOID:10534); cancer (Disease Ontology:DOID:162); hematologic cancer (Disease Ontology:DOID:2531); insulinoma (Disease Ontology:DOID:3892); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": "", "pathway_count": 0, "publication_count": 4, "publication_id_list": "22673903;27250217;27986613;7913462", "class_list": "", "function": "Hyperoxia resulted in a reduction of neurons expressing Cux1, [RefSeq, PubMed]; In arcuate nucleus of hypothalamus, CUX1 gene was co-expressed in the kisspeptin neurons., [RefSeq, PubMed]; Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1., [UniProtKB, UniProtKB]; Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F1LRC5", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0030674 protein-macromolecule adaptor activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0042491 inner ear auditory receptor cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0001822 kidney development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P53565-1", "record_type": "protein", "filter_code": "0000000.0000110.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIN9-1", "uniprot_id": [ { "id": "CCD81_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIN9", "type": "external" } ], "mass": 75314.0, "length": 651, "protein_name": "Coiled-coil domain-containing protein 81", "gene_name": "Ccdc81", "organism": "Rat", "refseq_name": "coiled-coil domain-containing protein 81", "refseq_ac": [ { "id": "NP_001014043", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014043", "type": "external" } ], "gene_names_uniprotkb": "Ccdc81", "gene_names_refseq": "Ccdc81; RGD1306766", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 81", "protein_names_refseq": "coiled-coil domain-containing protein 81", "tax_id": 10116, "disease": "", "pathway": " (rno:308810)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005815 microtubule organizing center;GO:0036064 ciliary basal body", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XIN9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88419-1", "uniprot_id": [ { "id": "B4GT6_RAT", "url": "https://www.uniprot.org/uniprot/O88419", "type": "external" } ], "mass": 44778.0, "length": 382, "protein_name": "Beta-1,4-galactosyltransferase 6", "gene_name": "B4galt6", "organism": "Rat", "refseq_name": "beta-1,4-galactosyltransferase 6", "refseq_ac": [ { "id": "NP_113928", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113928", "type": "external" } ], "gene_names_uniprotkb": "B4galt6", "gene_names_refseq": "B4galt6", "protein_names_uniprotkb": "Beta-1,4-galactosyltransferase 6; 2.4.1.-; 2.4.1.274; Beta-1,4-GalTase 6; Beta4Gal-T6; Glucosylceramide beta-1,4-galactosyltransferase; LacCer synthase; Lactosylceramide synthase; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 6; UDP-Gal:glucosylceramide beta-1,4-galactosyltransferase; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 6; b4Gal-T6", "protein_names_refseq": "LacCer synthase; Lactosylceramide Synthase; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 6; UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6; UDP-Gal:glucosylceramide beta-1,4-galactosyltransferase; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 6; b4Gal-T6; beta-1,4-GalTase 6; beta-1,4-galactosyltransferase 6; beta4Gal-T6; glucosylceramide beta-1,4-galactosyltransferase", "tax_id": 10116, "disease": "multiple sclerosis (Disease Ontology:DOID:2377)", "pathway": " (rno:65196); (R-RNO-2022854); (R-RNO-913709); (R-RNO-975577); (R-RNO-9840309)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "9593693", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer) (PubMed:9593693). LacCer is the starting point in the biosynthesis of all gangliosides (membrane-bound glycosphingolipids) which play pivotal roles in the CNS including neuronal maturation and axonal and myelin formation (By similarity)., [UniProtKB, UniProtKB, PubMed]; Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.274", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.274", "type": "external" }, { "id": "2.4.1.275", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.275", "type": "external" }, { "id": "2.4.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.90", "type": "external" }, { "id": "2.4.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.38", "type": "external" } ], "go_molecular_function": "GO:0008378 galactosyltransferase activity;GO:0046872 metal ion binding;GO:0008489 UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity;GO:0016757 glycosyltransferase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0032580 Golgi cisterna membrane;GO:0000139 Golgi membrane", "go_biological_process": "GO:0006688 glycosphingolipid biosynthetic process;GO:0022010 central nervous system myelination;GO:0005975 carbohydrate metabolic process;GO:0021955 central nervous system neuron axonogenesis;GO:0001572 lactosylceramide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O88419-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000001000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JK71-1", "uniprot_id": [ { "id": "MAGI3_RAT", "url": "https://www.uniprot.org/uniprot/Q9JK71", "type": "external" } ], "mass": 160563.0, "length": 1470, "protein_name": "Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3", "gene_name": "Magi3", "organism": "Rat", "refseq_name": "membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3", "refseq_ac": [ { "id": "NP_620784", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620784", "type": "external" } ], "gene_names_uniprotkb": "Magi3; Slipr", "gene_names_refseq": "Magi3; Slipr", "protein_names_uniprotkb": "Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3; MAGI-3; Membrane-associated guanylate kinase inverted 3; Scaffolding-like protein", "protein_names_refseq": "MAGI-3; membrane-associated guanylate kinase inverted 3; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3; membrane-associated guanylate kinase-related (MAGI-3); scaffolding protein SLIPR; scaffolding-like protein", "tax_id": 10116, "disease": "", "pathway": " (rno:245903)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12615970;15951562;16316992;22673903;34985721", "class_list": "", "function": "Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; MiR-20b-5p contributes to the dysfunction of vascular smooth muscle cells by targeting MAGI3 in hypertension., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005109 frizzled binding;GO:0005524 ATP binding;GO:0019903 protein phosphatase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005923 bicellular tight junction", "go_biological_process": "GO:0007165 signal transduction;GO:0043507 positive regulation of JUN kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9JK71-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3MJK5-1", "uniprot_id": [ { "id": "CDK12_RAT", "url": "https://www.uniprot.org/uniprot/Q3MJK5", "type": "external" } ], "mass": 163790.0, "length": 1484, "protein_name": "Cyclin-dependent kinase 12", "gene_name": "Cdk12", "organism": "Rat", "refseq_name": "cyclin-dependent kinase 12 isoform 1", "refseq_ac": [ { "id": "NP_001029039", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029039", "type": "external" } ], "gene_names_uniprotkb": "Cdk12; Crk7; Crkrs; Pksc", "gene_names_refseq": "Cdk12; Crk7; Crkrs; Hgn; Pksc", "protein_names_uniprotkb": "Cyclin-dependent kinase 12; 2.7.11.22; 2.7.11.23; CDC2-related protein kinase 7; Cdc2-related kinase, arginine/serine-rich; Cell division cycle 2-related protein kinase 7; Cell division protein kinase 12; CrkRS; Protein kinase for splicing component", "protein_names_refseq": "CDC2-related kinase 7; CDC2-related protein kinase 7; Cdc2-related kinase, arginine/serine-rich; cell division cycle 2-related protein kinase 7; cell division protein kinase 12; cyclin-dependent kinase 12 isoform 1; hippyragranin; protein kinase for splicing component", "tax_id": 10116, "disease": "stomach cancer (Disease Ontology:DOID:10534); gastric adenocarcinoma (Disease Ontology:DOID:3717); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:192350); (R-RNO-6796648)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "16537916;22673903;29393594", "class_list": "", "function": "CDK12 and cyclin L1/L2 are cyclin-dependent kinase and cyclin partners and regulate alternative splicing., [RefSeq, PubMed]; Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors (By similarity). Required for RNA splicing, possibly by phosphorylating SRSF1/SF2., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 38, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R458", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0019908 nuclear cyclin-dependent protein kinase holoenzyme complex;GO:0002944 cyclin K-CDK12 complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0008380 RNA splicing;GO:0006366 transcription by RNA polymerase II;GO:0043484 regulation of RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3MJK5-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0ZCA7-1", "uniprot_id": [ { "id": "CLC2L_RAT", "url": "https://www.uniprot.org/uniprot/Q0ZCA7", "type": "external" } ], "mass": 23623.0, "length": 211, "protein_name": "C-type lectin domain family 2 member L", "gene_name": "Clec2l", "organism": "Rat", "refseq_name": "C-type lectin domain family 2 member L", "refseq_ac": [ { "id": "NP_001037698", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001037698", "type": "external" } ], "gene_names_uniprotkb": "Clec2l", "gene_names_refseq": "Clec2l; RGD1565373", "protein_names_uniprotkb": "C-type lectin domain family 2 member L", "protein_names_refseq": "C-type lectin domain family 2 member L; C-type lectin domain family, member L; CD69-like protein", "tax_id": 10116, "disease": "", "pathway": " (rno:296985)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0ZCA7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JM47-1", "uniprot_id": [ { "id": "CSEN_RAT", "url": "https://www.uniprot.org/uniprot/Q9JM47", "type": "external" } ], "mass": 29471.0, "length": 256, "protein_name": "Calsenilin", "gene_name": "Kcnip3", "organism": "Rat", "refseq_name": "calsenilin", "refseq_ac": [ { "id": "NP_115851", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_115851", "type": "external" } ], "gene_names_uniprotkb": "Kcnip3; Csen; Dream; Kchip3", "gene_names_refseq": "Csen; Dream; Kcnip3; rKChIP3", "protein_names_uniprotkb": "Calsenilin; A-type potassium channel modulatory protein 3; DRE-antagonist modulator; DREAM; KChIP3; Kv channel-interacting protein 3", "protein_names_refseq": "A-type potassium channel modulating protein 3; A-type potassium channel modulatory protein 3; DRE-antagonist modulator; KChIP3; Kv channel interacting protein 3, calsenilin; calsenilin, presenilin-binding protein, EF hand transcription factor; calsenilin; downstream regulatory element-antagonist modulator; kv channel-interacting protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:65199); (R-RNO-5576894)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10676964;12006572;12409095;15356203;15485870;16123112;22673903;25218926;28952229;29335353;31696766;32671697", "class_list": "", "function": "Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception (By similarity)., [UniProtKB, UniProtKB]; DREAM expression and REM sleep deprivation, as well as sleep recovery, are linked which may indicate potential involvement of DREAM in REM sleep-induced changes in gene expression, specifically in nociceptive processing., [RefSeq, PubMed]; Findings of DREAM expression in the pituitary in a manner specific to pituitary endocrine cell type raises the possibility that this protein may play a role in determining specific pituitary cell function.[DREAM protein], [RefSeq, PubMed]; HDAC4 and HDAC5 form a complex with DREAM that epigenetically down-regulates NCX3 gene and its pharmacological inhibition reduces neuronal stroke damage., [RefSeq, PubMed]; Ifenprodil Reduced Expression of Activated Microglia, BDNF and DREAM Proteins in the Spinal Cord Following Formalin Injection During the Early Stage of Painful Diabetic Neuropathy in Rats., [RefSeq, PubMed]; May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of amyloid-beta formation (By similarity)., [UniProtKB, UniProtKB]; NF-kB signal pathway promoted the expression of DREAM gene., [RefSeq, PubMed]; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner (By similarity)., [UniProtKB, UniProtKB]; The KChIP3-TRPV1 interaction reduces the surface localization of TRPV1 and thus alleviates heat hyperalgesia and gait alterations induced by peripheral inflammation, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003677 DNA binding;GO:0042803 protein homodimerization activity;GO:0048306 calcium-dependent protein binding;GO:0015459 potassium channel regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0030424 axon", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006886 intracellular protein transport;GO:0072659 protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9JM47-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EPI6-1", "uniprot_id": [ { "id": "NSMF_RAT", "url": "https://www.uniprot.org/uniprot/Q9EPI6", "type": "external" } ], "mass": 60282.0, "length": 532, "protein_name": "NMDA receptor synaptonuclear signaling and neuronal migration factor", "gene_name": "Nsmf", "organism": "Rat", "refseq_name": "NMDA receptor synaptonuclear signaling and neuronal migration factor isoform 2", "refseq_ac": [ { "id": "NP_001257555", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257555", "type": "external" } ], "gene_names_uniprotkb": "Nsmf; Jac; Nelf", "gene_names_refseq": "Jacob; Jac; Nelf; Nsmf", "protein_names_uniprotkb": "NMDA receptor synaptonuclear signaling and neuronal migration factor; Jacob protein; Juxtasynaptic attractor of caldendrin on dendritic boutons protein; Nasal embryonic LHRH factor; Nasal embryonic luteinizing hormone-releasing hormone factor", "protein_names_refseq": "NMDA receptor synaptonuclear signaling and neuronal migration factor isoform 2; juxtasynaptic attractor of caldendrin on dendritic boutons protein; nasal embryonic LHRH factor; nasal embryonic luteinizing hormone-releasing hormone factor", "tax_id": 10116, "disease": "hypogonadotropic hypogonadism 7 with or without anosmia (Disease Ontology:DOID:0090078); hypogonadotropic hypogonadism 9 with or without anosmia (Disease Ontology:DOID:0090085)", "pathway": " (rno:117536)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15018815;18303947;19014935;19608740;21364755;22673903;23452857;23539133;25248434;33436037", "class_list": "", "function": "Calpain-mediated clipping of the myristoylated N terminus of Jacob is required for its nuclear translocation after N-methyl-d-aspartate receptor activation, [RefSeq, PubMed]; Couples NMDA-sensitive glutamate receptor signaling to the nucleus and triggers long-lasting changes in the cytoarchitecture of dendrites and spine synapse processes. Part of the cAMP response element-binding protein (CREB) shut-off signaling pathway. Stimulates outgrowth of olfactory axons and migration of gonadotropin-releasing hormone (GnRH) and luteinizing-hormone-releasing hormone (LHRH) neuronal cells., [UniProtKB, PubMed]; Data support a synaptic and nuclear role of Jacob that implicates long-distance NMDAR signaling to the nucleus in excitatory neurons, [RefSeq, PubMed]; NELF controls overall immediate early gene transcription via multiple mechanisms both directly and indirectly., [RefSeq, PubMed]; Nsmf is a novel myogenic factor that can enhance myoblast proliferation., [RefSeq, PubMed]; Nuclear translocation of jacob in hippocampal neurons after stimuli inducing long-term potentiation but not long-term depression. Erratum:[PLoS One. 2011;6(3). doi: 10.1371/annotation/8d9dd14e-08f6-4f7e-b881-ba2839724e23] Publication Status: Online-Only, [RefSeq, PubMed]; Study demonstrates that Jacob is a protein messenger that encodes the origin of synaptic versus extrasynaptic N-methyl-D-aspartate-receptors signals and delivers them to the nucleus., [RefSeq, PubMed]; The nuclear lamina is a hub for the nuclear function of Jacob. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5PPF6;Q7TSC6;Q7TSC8;Q9EPI4;Q9EPI5", "ec_number_list": [], "go_molecular_function": "GO:0048306 calcium-dependent protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0048814 regulation of dendrite morphogenesis;GO:0043523 regulation of neuron apoptotic process;GO:0048168 regulation of neuronal synaptic plasticity;GO:0071230 cellular response to amino acid stimulus;GO:0071257 cellular response to electrical stimulus", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9EPI6-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8IHN8-1", "uniprot_id": [ { "id": "CK096_RAT", "url": "https://www.uniprot.org/uniprot/A8IHN8", "type": "external" } ], "mass": 26097.0, "length": 242, "protein_name": "Uncharacterized protein C11orf96 homolog", "gene_name": "Ag2; C3h11orf96", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ag2; C3h11orf96", "gene_names_refseq": "", "protein_names_uniprotkb": "Uncharacterized protein C11orf96 homolog; Protein Ag2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:499839)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10820183;22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A8IHN8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A770-1", "uniprot_id": [ { "id": "FERY3_RAT", "url": "https://www.uniprot.org/uniprot/D4A770", "type": "external" } ], "mass": 63619.0, "length": 552, "protein_name": "FERRY endosomal RAB5 effector complex subunit 3", "gene_name": "Ferry3", "organism": "Rat", "refseq_name": "FERRY endosomal RAB5 effector complex subunit 3", "refseq_ac": [ { "id": "NP_001100093", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100093", "type": "external" } ], "gene_names_uniprotkb": "Ferry3", "gene_names_refseq": "C4h12orf4; Ferry3; RGD1311164; chromosome 12 open reading frame 4", "protein_names_uniprotkb": "FERRY endosomal RAB5 effector complex subunit 3", "protein_names_refseq": "FERRY endosomal RAB5 effector complex subunit 3; protein C12orf4 homolog; uncharacterized protein C12orf4 homolog", "tax_id": 10116, "disease": "autosomal recessive intellectual developmental disorder 66 (Disease Ontology:DOID:0081227)", "pathway": " (rno:297607)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "25122211", "class_list": "", "function": "Component of the FERRY complex (Five-subunit Endosomal Rab5 and RNA/ribosome intermediary). The FERRY complex directly interacts with mRNAs and RAB5A, and functions as a RAB5A effector involved in the localization and the distribution of specific mRNAs most likely by mediating their endosomal transport. The complex recruits mRNAs and ribosomes to early endosomes through direct mRNA-interaction (By similarity). Plays a role in mast cell degranulation (PubMed:25122211)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0032991 protein-containing complex", "go_biological_process": "GO:0043304 regulation of mast cell degranulation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4A770-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ERQ6-1", "uniprot_id": [ { "id": "CSPG5_RAT", "url": "https://www.uniprot.org/uniprot/Q9ERQ6", "type": "external" } ], "mass": 60959.0, "length": 571, "protein_name": "Chondroitin sulfate proteoglycan 5", "gene_name": "Cspg5", "organism": "Rat", "refseq_name": "chondroitin sulfate proteoglycan 5 isoform 2 precursor", "refseq_ac": [ { "id": "NP_598413", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598413", "type": "external" } ], "gene_names_uniprotkb": "Cspg5; Caleb; Ngc", "gene_names_refseq": "Caleb; Cspg5; Ngc", "protein_names_uniprotkb": "Chondroitin sulfate proteoglycan 5; Acidic leucine-rich EGF-like domain-containing brain protein; Neuroglycan C", "protein_names_refseq": "acidic leucine-rich EGF-like domain-containing brain protein; chondroitin sulfate proteoglycan 5 isoform 2 precursor; neuroglycan C", "tax_id": 10116, "disease": "", "pathway": " (rno:50568); (R-RNO-1971475); (R-RNO-2022870); (R-RNO-2022923); (R-RNO-2024101)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "11069908;11095636;11929867;12358776;16901907;17431398;27412363;32653642;7592931;9950058", "class_list": "", "function": "Chondroitin sulfate proteoglycan-5 forms perisynaptic matrix assemblies in the adult rat cortex., [RefSeq, PubMed]; May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation., [UniProtKB]; Neuroglycan C is a novel component of midkine receptors involved in process elongation, [RefSeq, PubMed]; PI3K-Akt-mammalian target of rapamycin (mTOR) signaling pathway and PKC are important for CALEB/NGC-induced stimulation of dendritic branching. CALEB/NGC-induced spine morphogenesis is independent of PI3K but depends on PKC., [RefSeq, PubMed]; Rac1, Cdc42, and RhoG perform very specific and non-redundant functions at different levels of hierarchy in regulating dendritic tree complexity induced by CALEB/NGC, [RefSeq, PubMed]", "predicted_glycosites": 16, "predicted_n_glycosites": 2, "predicted_o_glycosites": 14, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 16, "binding_glycan_count": 0, "secondary_ac_list": "Q62831", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0007010 cytoskeleton organization;GO:1900026 positive regulation of substrate adhesion-dependent cell spreading;GO:0050804 modulation of chemical synaptic transmission;GO:0031103 axon regeneration;GO:2000300 regulation of synaptic vesicle exocytosis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9ERQ6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50463-1", "uniprot_id": [ { "id": "CSRP3_RAT", "url": "https://www.uniprot.org/uniprot/P50463", "type": "external" } ], "mass": 20803.0, "length": 194, "protein_name": "Cysteine and glycine-rich protein 3", "gene_name": "Csrp3", "organism": "Rat", "refseq_name": "cysteine and glycine-rich protein 3", "refseq_ac": [ { "id": "NP_476485", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476485", "type": "external" } ], "gene_names_uniprotkb": "Csrp3; Clp; Mlp", "gene_names_refseq": "CRP3; Csrp3; MLP", "protein_names_uniprotkb": "Cysteine and glycine-rich protein 3; CRP3; Cysteine-rich protein 3; LIM domain protein, cardiac; Muscle LIM protein", "protein_names_refseq": "LIM domain protein, cardiac; cysteine and glycine rich protein 3 N-terminal nuclear localization sequence; cysteine and glycine rich protein 3 c-terminal HA-tagged; cysteine and glycine rich protein 3 lacking the LIM1-domain; cysteine and glycine-rich protein 3 (cardiac LIM protein); cysteine and glycine-rich protein 3; cysteine-rich protein 3; muscle LIM protein", "tax_id": 10116, "disease": "hypertrophic cardiomyopathy 12 (Disease Ontology:DOID:0110318); dilated cardiomyopathy 1M (Disease Ontology:DOID:0110449); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (rno:117505)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10751147;12127981;16963613;18258855;19376126;22673903;30673598;32914385;7954791;9234731", "class_list": "", "function": "Discriminating aspects of global metabolism of neonatal cardiomyocytes from wild type and KO-CSRP3 rats using proton magnetic resonance spectroscopy of culture media samples., [RefSeq, PubMed]; Muscle LIM Protein Is Expressed in the Injured Adult CNS and Promotes Axon Regeneration., [RefSeq, PubMed]; Positive regulator of myogenesis. Acts as a cofactor for myogenic bHLH transcription factors such as MYOD1, and probably MYOG and MYF6. Enhances the DNA-binding activity of the MYOD1:TCF3 isoform E47 complex and may promote formation of a functional MYOD1:TCF3 isoform E47:MEF2A complex involved in myogenesis (PubMed:7954791, PubMed:9234731). Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation. The role in regulation of cytoskeleton dynamics by association with CFL2 is reported conflictingly. Proposed to contribute to the maintenance of muscle cell integrity through an actin-based mechanism. Can directly bind to actin filaments, cross-link actin filaments into bundles without polarity selectivity and protect them from dilution- and cofilin-mediated depolymerization; the function seems to involve its self-association. In vitro can inhibit PKC/PRKCA activity. Proposed to be involved in cardiac stress signaling by down-regulating excessive PKC/PRKCA signaling (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0008307 structural constituent of muscle;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0030018 Z disc", "go_biological_process": "GO:0010831 positive regulation of myotube differentiation;GO:0035995 detection of muscle stretch;GO:0072594 establishment of protein localization to organelle;GO:0006351 DNA-templated transcription;GO:0006954 inflammatory response", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P50463-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35786-1", "uniprot_id": [ { "id": "CML1_RAT", "url": "https://www.uniprot.org/uniprot/O35786", "type": "external" } ], "mass": 41865.0, "length": 372, "protein_name": "Chemerin-like receptor 1", "gene_name": "Cmklr1", "organism": "Rat", "refseq_name": "chemerin-like receptor 1", "refseq_ac": [ { "id": "NP_071554", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071554", "type": "external" } ], "gene_names_uniprotkb": "Cmklr1; Dez", "gene_names_refseq": "Cmklr1", "protein_names_uniprotkb": "Chemerin-like receptor 1; Chemokine-like receptor 1; G protein-coupled chemoattractant-like receptor; G protein-coupled receptor DEZ", "protein_names_refseq": "G-protein coupled chemoattractant-like receptor; G-protein coupled receptor DEZ; chemerin-like receptor 1; chemokine receptor-like 1; chemokine-like receptor 1", "tax_id": 10116, "disease": "", "pathway": " (rno:60669); (R-RNO-373076)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "17033093;22673903;29393594;31965243;32462328;34461109;34769243;37932279;9425281", "class_list": "", "function": "Acute intracerebroventricular injection of chemerin-9 increases systemic blood pressure through activating sympathetic nerves via CMKLR1 in brain., [RefSeq, PubMed]; ChemR23 activation attenuates cognitive impairment in chronic cerebral hypoperfusion by inhibiting NLRP3 inflammasome-induced neuronal pyroptosis. Publication Status: Online-Only, [RefSeq, PubMed]; Chemerin-9-induced contraction was enhanced through the upregulation of smooth muscle chemokine-like receptor 1 in isolated pulmonary artery of pulmonary arterial hypertensive rats., [RefSeq, PubMed]; Chemokine-like Receptor 1 in Brain of Spontaneously Hypertensive Rats Mediates Systemic Hypertension. Publication Status: Online-Only, [RefSeq, PubMed]; Data suggest the importance of immune response- and microglia activation-related genes in chronic neuropathic pain. Expression of the Calca (aka CGRP) gene in the dorsal horn of the spinal cord could be involved in persistence of its symptoms., [RefSeq, PubMed]; HOXA9-induced chemerin signals through CMKLR1/AMPK/TXNIP/NLRP3 pathway to induce pyroptosis of trophoblasts and aggravate preeclampsia., [RefSeq, PubMed]; Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 initiates activation of G proteins G(i)/G(o) and beta-arrestin pathways inducing cellular responses via second messenger pathways such as intracellular calcium mobilization, phosphorylation of MAP kinases MAPK1/MAPK3 (ERK1/2), TYRO3, MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "G3V625", "ec_number_list": [], "go_molecular_function": "GO:0004875 complement receptor activity;GO:0004930 G protein-coupled receptor activity;GO:0097003 adipokinetic hormone receptor activity;GO:0001637 G protein-coupled chemoattractant receptor activity;GO:0097004 adipokinetic hormone binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0002430 complement receptor mediated signaling pathway;GO:0006935 chemotaxis;GO:0006954 inflammatory response;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O35786-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02524-1", "uniprot_id": [ { "id": "CRBB3_RAT", "url": "https://www.uniprot.org/uniprot/P02524", "type": "external" } ], "mass": 24334.0, "length": 211, "protein_name": "Beta-crystallin B3", "gene_name": "Crybb3", "organism": "Rat", "refseq_name": "beta-crystallin B3", "refseq_ac": [ { "id": "NP_113878", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113878", "type": "external" } ], "gene_names_uniprotkb": "Crybb3", "gene_names_refseq": "Crybb3", "protein_names_uniprotkb": "Beta-crystallin B3; Beta-B3 crystallin", "protein_names_refseq": "beta-B3 crystallin; beta-crystallin B3", "tax_id": 10116, "disease": "cataract 22 multiple types (Disease Ontology:DOID:0110268)", "pathway": " (rno:64349)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11773034;3879970;8405363", "class_list": "", "function": "Crystallins are the dominant structural components of the vertebrate eye lens., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P70522;Q9ET12", "ec_number_list": [], "go_molecular_function": "GO:0005212 structural constituent of eye lens", "go_cellular_component": "", "go_biological_process": "GO:0007601 visual perception;GO:0002088 lens development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P02524-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10354-1", "uniprot_id": [ { "id": "CMGA_RAT", "url": "https://www.uniprot.org/uniprot/P10354", "type": "external" } ], "mass": 52024.0, "length": 466, "protein_name": "Chromogranin-A", "gene_name": "Chga", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Chga", "gene_names_refseq": "", "protein_names_uniprotkb": "Chromogranin-A; CgA", "protein_names_refseq": "", "tax_id": 10116, "disease": "pheochromocytoma (Disease Ontology:DOID:0050771); prostate cancer (Disease Ontology:DOID:10283); hypertension (Disease Ontology:DOID:10763); IgA glomerulonephritis (Disease Ontology:DOID:2986); end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (R-RNO-6803157)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12388744;14597614;22459152;22673903;2828116;29166604;3044825;3896848", "class_list": "", "function": "Catestatin inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist. Can induce mast cell migration, degranulation and production of cytokines and chemokines., [UniProtKB, UniProtKB]; Serpinin regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation (By similarity). Serpinin and pGlu-serpinin can enhance both myocardial contractility (inotropy) and relaxation (lusitropy) and this cardio-stimulation requires a beta 1-adrenergic receptor/adenylate cyclase/cAMP/PKA pathway (PubMed:22459152)., [UniProtKB, UniProtKB, PubMed]; Strongly inhibits glucose induced insulin release from the pancreas., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098992 neuronal dense core vesicle;GO:0005615 extracellular space;GO:0030141 secretory granule;GO:0048471 perinuclear region of cytoplasm;GO:0030133 transport vesicle", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0051480 regulation of cytosolic calcium ion concentration;GO:0045907 positive regulation of vasoconstriction", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P10354-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13601-1", "uniprot_id": [ { "id": "AL1A7_RAT", "url": "https://www.uniprot.org/uniprot/P13601", "type": "external" } ], "mass": 54560.0, "length": 501, "protein_name": "Aldehyde dehydrogenase, cytosolic 1", "gene_name": "Aldh1a7", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Aldh1a7; Aldh-pb; Aldh1a4; Aldh1", "gene_names_refseq": "", "protein_names_uniprotkb": "Aldehyde dehydrogenase, cytosolic 1; 1.2.1.3; ALDH class 1; ALDH-E1; ALHDII; Aldehyde dehydrogenase family 1 member A7; Aldehyde dehydrogenase phenobarbital-inducible", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "10998257;2753900;34502162", "class_list": "", "function": "Can oxidize benzaldehyde, propionaldehyde and acetaldehyde. No detectable activity with retinal., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "1.2.1.94", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.94", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.2.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.19", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "1.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.31", "type": "external" }, { "id": "1.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.8", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.47", "type": "external" }, { "id": "1.2.1.46", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.46", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0051287 NAD binding;GO:0004028 3-chloroallyl aldehyde dehydrogenase activity;GO:0004029 aldehyde dehydrogenase (NAD+) activity;GO:0018479 benzaldehyde dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0035106 operant conditioning;GO:0006068 ethanol catabolic process;GO:0006081 aldehyde metabolic process;GO:0006001 fructose catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P13601-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15207-1", "uniprot_id": [ { "id": "ANDR_RAT", "url": "https://www.uniprot.org/uniprot/P15207", "type": "external" } ], "mass": 98244.0, "length": 902, "protein_name": "Androgen receptor", "gene_name": "Ar", "organism": "Rat", "refseq_name": "androgen receptor", "refseq_ac": [ { "id": "NP_036634", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036634", "type": "external" } ], "gene_names_uniprotkb": "Ar; Nr3c4", "gene_names_refseq": "Andr; Ar; Tfm", "protein_names_uniprotkb": "Androgen receptor; Dihydrotestosterone receptor; Nuclear receptor subfamily 3 group C member 4", "protein_names_refseq": "androgen receptor (Testicular feminization), same as Tfm; androgen receptor; dihydrotestosterone receptor; nuclear receptor subfamily 3 group C member 4", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); oppositional defiant disorder (Disease Ontology:DOID:0050856); ductal carcinoma in situ (Disease Ontology:DOID:0060074); Kennedy's disease (Disease Ontology:DOID:0060161); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); partial androgen insensitivity syndrome (Disease Ontology:DOID:0080776); prostate cancer (Disease Ontology:DOID:10283); hypertension (Disease Ontology:DOID:10763); hypospadias (Disease Ontology:DOID:10892); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); prostatic hypertrophy (Disease Ontology:DOID:11132); cryptorchidism (Disease Ontology:DOID:11383); osteoporosis (Disease Ontology:DOID:11476); spinal muscular atrophy (Disease Ontology:DOID:12377); leiomyoma (Disease Ontology:DOID:127); conduct disorder (Disease Ontology:DOID:12995); endometrial cancer (Disease Ontology:DOID:1380); prostate adenocarcinoma (Disease Ontology:DOID:2526); invasive ductal carcinoma (Disease Ontology:DOID:3008); acute kidney failure (Disease Ontology:DOID:3021); androgen insensitivity syndrome (Disease Ontology:DOID:4674); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24208); (R-RNO-3371497); (R-RNO-383280); (R-RNO-4090294); (R-RNO-5625886); (R-RNO-5689880)", "pathway_count": 6, "publication_count": 15, "publication_id_list": "11320241;12350225;15037741;15603938;17008401;17181141;22673903;2341409;3174628;3216867;35982617;36379312;37669164;38976730;9725910", "class_list": "", "function": "Activation of androgen receptors alters hippocampal synaptic plasticity and memory retention through modulation of L-type calcium channels. Erratum:[Life Sci. 2023 Jul 1;324:121756. doi: 10.1016/j.lfs.2023.121756. PMID: 37164836], [RefSeq, PubMed]; Androgen receptor suppresses inflammatory response of airway epithelial cells in allergic asthma through MAPK1 and MAPK14., [RefSeq, PubMed]; Bromodomain-containing protein 4 activates androgen receptor transcription and promotes ovarian fibrosis in PCOS., [RefSeq, PubMed]; Mutant androgen receptor induces neurite loss and senescence independently of ARE binding in a neuronal model of SBMA., [RefSeq, PubMed]; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 23, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A0G2JSI8;A6IQ56;Q63049", "ec_number_list": [], "go_molecular_function": "GO:0034056 estrogen response element binding;GO:0060090 molecular adaptor activity;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016607 nuclear speck", "go_biological_process": "GO:0008049 male courtship behavior;GO:0046661 male sex differentiation;GO:0060406 positive regulation of penile erection;GO:0060685 regulation of prostatic bud formation;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P15207-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19313-1", "uniprot_id": [ { "id": "CYTS_RAT", "url": "https://www.uniprot.org/uniprot/P19313", "type": "external" } ], "mass": 15949.0, "length": 141, "protein_name": "Cystatin-S", "gene_name": "Cst4", "organism": "Rat", "refseq_name": "cystatin-S precursor", "refseq_ac": [ { "id": "NP_941958", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_941958", "type": "external" } ], "gene_names_uniprotkb": "Cst4; Cyss", "gene_names_refseq": "Cst4; Cyss", "protein_names_uniprotkb": "Cystatin-S; Cystatin-1; Protein LM", "protein_names_refseq": "LM protein; cystatin-1; cystatin-S precursor; protein LM", "tax_id": 10116, "disease": "", "pathway": " (rno:296234)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "1537554;2757396;3263967", "class_list": "", "function": "This protein strongly inhibits papain and ficin, partially inhibits stem bromelain and bovine cathepsin C, but does not inhibit porcine cathepsin B or clostripain. Papain is inhibited non-competitively., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0004869 cysteine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0030141 secretory granule;GO:0031982 vesicle", "go_biological_process": "GO:0010466 negative regulation of peptidase activity;GO:0008285 negative regulation of cell population proliferation;GO:0009725 response to hormone;GO:0048678 response to axon injury;GO:0009410 response to xenobiotic stimulus", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P19313-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24623-1", "uniprot_id": [ { "id": "CRYAA_RAT", "url": "https://www.uniprot.org/uniprot/P24623", "type": "external" } ], "mass": 22447.0, "length": 196, "protein_name": "Alpha-crystallin A chain", "gene_name": "Cryaa", "organism": "Rat", "refseq_name": "alpha-crystallin A chain isoform 2", "refseq_ac": [ { "id": "NP_001276666", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276666", "type": "external" } ], "gene_names_uniprotkb": "Cryaa; Crya1", "gene_names_refseq": "Acry-1; Crya1; Cryaa", "protein_names_uniprotkb": "Alpha-crystallin A chain", "protein_names_refseq": "Crystallin, alpha polypeptide A; alpha-crystallin A chain isoform 2; alpha-crystallin A chain", "tax_id": 10116, "disease": "adult-onset myofibrillar myopathy 2A (Disease Ontology:DOID:0080093); Charcot-Marie-Tooth disease axonal type 2L (Disease Ontology:DOID:0110174); cataract 9 multiple types (Disease Ontology:DOID:0110266); autosomal dominant distal hereditary motor neuronopathy 2 (Disease Ontology:DOID:0111206); neurodegenerative disease (Disease Ontology:DOID:1289); cataract (Disease Ontology:DOID:83); ocular hypertension (Disease Ontology:DOID:9282); galactosemia (Disease Ontology:DOID:9870)", "pathway": " (rno:24273)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "12118077;12356833;1429679;1730617;2294971;23071119;23142719;23508955;26378715;6171772;699911;7556464;8875649", "class_list": "", "function": "AlphaA-crystallin and alphaB-crystallin reside in separate subcellular compartments in the developing ocular lens, [RefSeq, PubMed]; Contributes to the transparency and refractive index of the lens (By similarity). Acts as a chaperone, preventing aggregation of various proteins under a wide range of stress conditions (PubMed:12118077). Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA (By similarity)., [UniProtKB, UniProtKB, PubMed]; Cryaa is a moonlighting protein that functions as a heat shock protein as well as a lens crystalline., [RefSeq, PubMed]; Inhibits bacterial growth in the lens., [UniProtKB, PubMed]; Rat crystallin alpha A a encode activated chaperones., [RefSeq, PubMed]; The alphaA- and alphaB-crystallin peptides inhibited stress-induced aggregation of four client proteins, and the alphaA-acetyl peptide was more effective than the native peptide against three of the client proteins., [RefSeq, PubMed]; These findings indicated that alpha-crystallin positively regulated the activation of PI3K/Akt/mTOR signaling pathway and promote the proliferation and survival of cultured olfactory ensheathing cells, [RefSeq, PubMed]; This gene encodes subunit a, one of two subunits of alpha-crystallin, which is a high molecular weight, soluble aggregate and is a member of the small heat shock protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. It acts as a molecular chaperone and is the major protein in the eye lens, maintaining the transparency and refractive index of the lens. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P02490;P02496;P82532;Q61444", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0051082 unfolded protein binding;GO:0005198 structural molecule activity;GO:0005212 structural constituent of eye lens", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0032991 protein-containing complex", "go_biological_process": "GO:0032387 negative regulation of intracellular transport;GO:0006750 glutathione biosynthetic process;GO:0001934 positive regulation of protein phosphorylation;GO:0007015 actin filament organization;GO:0010288 response to lead ion", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P24623-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32198-1", "uniprot_id": [ { "id": "CPT1A_RAT", "url": "https://www.uniprot.org/uniprot/P32198", "type": "external" } ], "mass": 88125.0, "length": 773, "protein_name": "Carnitine O-palmitoyltransferase 1, liver isoform", "gene_name": "Cpt1a", "organism": "Rat", "refseq_name": "carnitine O-palmitoyltransferase 1, liver isoform", "refseq_ac": [ { "id": "NP_113747", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113747", "type": "external" } ], "gene_names_uniprotkb": "Cpt1a; Cpt-1; Cpt1", "gene_names_refseq": "CPT-Ia; Cpt1a", "protein_names_uniprotkb": "Carnitine O-palmitoyltransferase 1, liver isoform; 2.3.1.-; 2.3.1.21; CPT I; CPT1-L; CPTI-L; Carnitine O-palmitoyltransferase I, liver isoform; Carnitine palmitoyltransferase 1A; Succinyltransferase CPT1A", "protein_names_refseq": "CPT I; CPT1-L; CPTI-L; carnitine O-palmitoyltransferase 1, liver isoform; carnitine palmitoyltransferase 1, liver; carnitine palmitoyltransferase 1a, liver; succinyltransferase CPT1A", "tax_id": 10116, "disease": "metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); carnitine palmitoyltransferase I deficiency (Disease Ontology:DOID:0090129); cataract 23 (Disease Ontology:DOID:0110271); alcoholic hepatitis (Disease Ontology:DOID:12351); lipid metabolism disorder (Disease Ontology:DOID:3146); lymphangioleiomyomatosis (Disease Ontology:DOID:3319); end stage renal disease (Disease Ontology:DOID:783); cataract (Disease Ontology:DOID:83); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25757); (R-RNO-200425)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "11553629;12499375;14711372;16908527;17478130;18192268;18349115;19136561;21622568;21990363;24222496;28100784;38843836;8348957;8449947;8449948;8636126;9136891;9169604", "class_list": "", "function": "Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion (PubMed:16908527, PubMed:21990363, PubMed:24222496). Also possesses a lysine succinyltransferase activity that can regulate enzymatic activity of substrate proteins such as ENO1 and metabolism independent of its classical carnitine O-palmitoyltransferase activity (By similarity). Plays an important role in hepatic triglyceride metabolism (PubMed:18349115). Also plays a role in inducible regulatory T-cell (iTreg) differentiation once activated by butyryl-CoA that antagonizes malonyl-CoA-mediated CPT1A repression (By similarity). Sustains the IFN-I response by recruiting ZDHCC4 to palmitoylate MAVS at the mitochondria leading to MAVS stabilization and activation (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 16, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P97780;Q6IMZ4", "ec_number_list": [ { "id": "2.3.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.21", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0004095 carnitine O-palmitoyltransferase activity;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0043279 response to alkaloid;GO:0001676 long-chain fatty acid metabolic process;GO:0006631 fatty acid metabolic process;GO:0006635 fatty acid beta-oxidation;GO:0006641 triglyceride metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P32198-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51869-1", "uniprot_id": [ { "id": "CP4F4_RAT", "url": "https://www.uniprot.org/uniprot/P51869", "type": "external" } ], "mass": 60050.0, "length": 522, "protein_name": "Cytochrome P450 4F4", "gene_name": "Cyp4f4", "organism": "Rat", "refseq_name": "cytochrome P450 4F4", "refseq_ac": [ { "id": "NP_775146", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775146", "type": "external" } ], "gene_names_uniprotkb": "Cyp4f4", "gene_names_refseq": "Cyp4f4", "protein_names_uniprotkb": "Cytochrome P450 4F4; 1.14.14.94; CYPIVF4; Leukotriene-B4 20-monooxygenase", "protein_names_refseq": "CYPIVF4; cytochrome P450 4F4; leukotriene-B4 20-monooxygenase", "tax_id": 10116, "disease": "hypertrophic cardiomyopathy (Disease Ontology:DOID:11984)", "pathway": " (rno:286904); (R-RNO-211935); (R-RNO-211958); (R-RNO-211979); (R-RNO-2142691); (R-RNO-2142816)", "pathway_count": 6, "publication_count": 6, "publication_id_list": "11980497;14634044;16182239;17418803;8554568;9344476", "class_list": "", "function": "A cytochrome P450 monooxygenase involved in the metabolism of arachidonic acid and its oxygenated derivatives (PubMed:14634044, PubMed:17418803, PubMed:9344476). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:14634044, PubMed:17418803, PubMed:9344476). Participates in the conversion of arachidonic acid to omega-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure (PubMed:14634044). Hydroxylates the terminal carbon (omega-hydroxylation) of inflammatory lipid mediators, including prostaglandin (PG) A1, PGE1 and leukotriene B4 (LTB4), and may play a role in inactivation of these oxylipins during the resolution of inflammation (PubMed:14634044, PubMed:17418803, PubMed:9344476)., [UniProtKB, PubMed, PubMed, PubMed]; CYP4Fs are regionally distributed in the spontaneously hypertensive rat (SHR) kidney with CYP4F1, 4F4, and 4F5 being more highly expressed in the renal cortex than medulla while CYP4F6 shows higher medullary expression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" }, { "id": "4.2.1.152", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.152", "type": "external" }, { "id": "1.14.14.80", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.80", "type": "external" }, { "id": "1.14.14.94", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.94", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0050051 leukotriene-B4 20-monooxygenase activity;GO:0052869 arachidonate omega-hydroxylase activity;GO:0008391 arachidonate monooxygenase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0097267 omega-hydroxylase P450 pathway;GO:1904681 response to 3-methylcholanthrene;GO:1905344 prostaglandin catabolic process;GO:0019369 arachidonate metabolic process;GO:0036101 leukotriene B4 catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P51869-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63079-1", "uniprot_id": [ { "id": "GBRB3_RAT", "url": "https://www.uniprot.org/uniprot/P63079", "type": "external" } ], "mass": 54166.0, "length": 473, "protein_name": "Gamma-aminobutyric acid receptor subunit beta-3", "gene_name": "Gabrb3", "organism": "Rat", "refseq_name": "gamma-aminobutyric acid receptor subunit beta-3 precursor", "refseq_ac": [ { "id": "NP_058761", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058761", "type": "external" } ], "gene_names_uniprotkb": "Gabrb3; Gabrb-3", "gene_names_refseq": "Gabrb3", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit beta-3; GABA(A) receptor subunit beta-3; GABAAR subunit beta-3", "protein_names_refseq": "GABA(A) receptor subunit beta-3; GABA-alpha receptor beta-3 subunit; GABAAR subunit beta-3; Gamma-aminobutyric acid receptor beta 3; gamma-aminobutyric acid (GABA) A receptor, beta 3; gamma-aminobutyric acid (GABA-A) receptor, subunit beta 3; gamma-aminobutyric acid receptor subunit beta-3 precursor; gamma-aminobutyric acid receptor subunit beta-3; gamma-aminobutyric acid type A receptor beta 3 subunit; testis gamma-aminobutyric acid receptor subunit beta 3", "tax_id": 10116, "disease": "Lennox-Gastaut syndrome (Disease Ontology:DOID:0050561); fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); alcohol dependence (Disease Ontology:DOID:0050741); developmental disorder of mental health (Disease Ontology:DOID:0060037); autism spectrum disorder (Disease Ontology:DOID:0060041); developmental and epileptic encephalopathy 43 (Disease Ontology:DOID:0080447); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); morbid obesity (Disease Ontology:DOID:11981); alcoholic hepatitis (Disease Ontology:DOID:12351); cholestasis (Disease Ontology:DOID:13580); extrahepatic cholestasis (Disease Ontology:DOID:13619); alcohol use disorder (Disease Ontology:DOID:1574); status epilepticus (Disease Ontology:DOID:1824); childhood absence epilepsy (Disease Ontology:DOID:1825); epilepsy (Disease Ontology:DOID:1826); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:24922); (R-RNO-977443)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10.1039/D0MO00044B;10462548;11528422;16641100;25172774;25284783;2540033;2548852;28279354;32383536;34106099;38843836;8382702;9092594;9464994;9882711", "class_list": "", "function": "Beta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:10462548, PubMed:2540033, PubMed:2548852, PubMed:9882711). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (PubMed:9092594). GABAARs containing beta-3/GABRB3 subunit are found at both synaptic and extrasynaptic sites (PubMed:9464994). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:10462548, PubMed:2540033, PubMed:9882711). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (PubMed:2540033). GABAARs containing alpha-1 and beta-3 subunits exhibit synaptogenic activity; the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation (By similarity). Extrasynaptic beta-3 receptors contribute to the tonic GABAergic inhibition (PubMed:9464994). GABAARs containing alpha-1, beta-3 and epsilon subunits may permit spontaneous chloride channel activity while preserving the structural information required for GABA-gated openings (PubMed:9882711). Beta-containing GABAARs can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation of sleep and wakefulness (By similarity). Plays an important role in somatosensation and in the production of antinociception (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Ectopic GABAA receptor beta3 subunit determines Cl(-) / HCO 3 - -ATPase and chloride transport in HEK 293FT cells., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 16, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "P15433", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0005216 monoatomic ion channel activity;GO:0042802 identical protein binding;GO:0035612 AP-2 adaptor complex binding;GO:0005254 chloride channel activity;GO:0004890 GABA-A receptor activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0061827 sperm head;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0042491 inner ear auditory receptor cell differentiation;GO:0060384 innervation;GO:0001964 startle response;GO:0050975 sensory perception of touch;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P63079-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P84087-1", "uniprot_id": [ { "id": "CPLX2_RAT", "url": "https://www.uniprot.org/uniprot/P84087", "type": "external" } ], "mass": 15394.0, "length": 134, "protein_name": "Complexin-2", "gene_name": "Cplx2", "organism": "Rat", "refseq_name": "complexin-2", "refseq_ac": [ { "id": "NP_446330", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446330", "type": "external" } ], "gene_names_uniprotkb": "Cplx2", "gene_names_refseq": "Cplx2", "protein_names_uniprotkb": "Complexin-2; CPX II; Complexin II; Synaphin-1", "protein_names_refseq": "CPX II; complexin II; complexin-2; synaphin-1", "tax_id": 10116, "disease": "depressive disorder (Disease Ontology:DOID:1596); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:116657)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10051208;10430466;10777504;11751907;15870114;15911881;16499873;33393983;36675068;7553862;7654227;9753100", "class_list": "", "function": "Complexin-2 redistributes to the membrane of muscle cells in response to insulin and contributes to GLUT4 translocation., [RefSeq, PubMed]; Involvement of miR-135a-5p Downregulation in Acute and Chronic Stress Response in the Prefrontal Cortex of Rats. Publication Status: Online-Only, [RefSeq, PubMed]; Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Also involved in mast cell exocytosis (PubMed:15870114)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O09056;Q13329;Q28184;Q64386", "ec_number_list": [], "go_molecular_function": "GO:0048306 calcium-dependent protein binding;GO:0000149 SNARE binding;GO:0017075 syntaxin-1 binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0044305 calyx of Held;GO:0005634 nucleus;GO:0005829 cytosol;GO:0030425 dendrite", "go_biological_process": "GO:0050804 modulation of chemical synaptic transmission;GO:0031915 positive regulation of synaptic plasticity;GO:0031630 regulation of synaptic vesicle fusion to presynaptic active zone membrane;GO:0016079 synaptic vesicle exocytosis;GO:0043303 mast cell degranulation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P84087-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q25C79-1", "uniprot_id": [ { "id": "AKIR2_RAT", "url": "https://www.uniprot.org/uniprot/Q25C79", "type": "external" } ], "mass": 22129.0, "length": 201, "protein_name": "Akirin-2", "gene_name": "Akirin2", "organism": "Rat", "refseq_name": "akirin-2", "refseq_ac": [ { "id": "NP_001035003", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035003", "type": "external" } ], "gene_names_uniprotkb": "Akirin2; FBI1", "gene_names_refseq": "Akirin2; FBI1; RGD1307791", "protein_names_uniprotkb": "Akirin-2; Fourteen-three-three beta interactant 1; Fourteen-three-three beta interacting protein 1", "protein_names_refseq": "akirin-2; fourteen-three-three beta interactant 1; fourteen-three-three beta interacting-protein 1", "tax_id": 10116, "disease": "opportunistic bacterial infectious disease (Disease Ontology:DOID:0050340)", "pathway": " (rno:297968)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "18460465;22673903;24223164;24468084", "class_list": "", "function": "Data indicate that the 14-3-3beta-FBI1/Akirin2 complex bound to the basal cell adhesion molecule (BCAM) promoter and repressed transcription. Publication Status: Online-Only, [RefSeq, PubMed]; Molecular adapter that acts as a bridge between a variety of multiprotein complexes, and which is involved in embryonic development, immunity, myogenesis and brain development (By similarity). Plays a key role in nuclear protein degradation by promoting import of proteasomes into the nucleus: directly binds to fully assembled 20S proteasomes at one end and to nuclear import receptor IPO9 at the other end, bridging them together and mediating the import of pre-assembled proteasome complexes through the nuclear pore (By similarity). Involved in innate immunity by regulating the production of interleukin-6 (IL6) downstream of Toll-like receptor (TLR): acts by bridging the NF-kappa-B inhibitor NFKBIZ and the SWI/SNF complex, leading to promote induction of IL6. Also involved in adaptive immunity by promoting B-cell activation. Involved in brain development: required for the survival and proliferation of cerebral cortical progenitor cells. Involved in myogenesis: required for skeletal muscle formation and skeletal development, possibly by regulating expression of muscle differentiation factors. Also plays a role in facilitating interdigital tissue regression during limb development (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Results suggest that FBI1/Akirin2 plays an important role in oncogenesis of LLC1 lung carcinoma cells, and this protein may also serve as an oncogene in other cancers, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0017053 transcription repressor complex", "go_biological_process": "GO:0009792 embryo development ending in birth or egg hatching;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0008284 positive regulation of cell population proliferation;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q25C79-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5QE80-1", "uniprot_id": [ { "id": "AOXC_RAT", "url": "https://www.uniprot.org/uniprot/Q5QE80", "type": "external" } ], "mass": 146751.0, "length": 1334, "protein_name": "Aldehyde oxidase 3", "gene_name": "Aox3", "organism": "Rat", "refseq_name": "aldehyde oxidase 3", "refseq_ac": [ { "id": "NP_001008527", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008527", "type": "external" } ], "gene_names_uniprotkb": "Aox3; Aoh1", "gene_names_refseq": "Aoh1; Aox3", "protein_names_uniprotkb": "Aldehyde oxidase 3; 1.17.3.-; 1.2.3.1; Aldehyde oxidase homolog 1; Azaheterocycle hydroxylase 3", "protein_names_refseq": "aldehyde oxidase 3; aldehyde oxidase homolog 1; azaheterocycle hydroxylase 3", "tax_id": 10116, "disease": "", "pathway": " (rno:493909)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15383531;17022944;17353002;19801639;22673903;23263164", "class_list": "", "function": "Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide and phthalazine, as well as aldehydes, such as benzaldehyde, retinal and pyridoxal. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Is probably involved in the regulation of reactive oxygen species homeostasis. Is a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. Also catalyzes nitric oxide (NO) production; under anaerobic conditions, reduces nitrite to NO with NADH or aldehyde as electron donor, but under aerobic conditions, NADH is the preferred substrate. These reactions may be catalyzed by several isozymes., [UniProtKB, PubMed, PubMed]; The current data indicate that adiponectin reduces AOX1 by activating PPAR-alpha whereas fatty liver disease is associated with elevated hepatic AOX1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.17.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.17.3.-", "type": "external" }, { "id": "1.2.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.1", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0042803 protein homodimerization activity;GO:0050660 flavin adenine dinucleotide binding;GO:0071949 FAD binding;GO:0004031 aldehyde oxidase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006805 xenobiotic metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q5QE80-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63009-1", "uniprot_id": [ { "id": "ANM1_RAT", "url": "https://www.uniprot.org/uniprot/Q63009", "type": "external" } ], "mass": 40522.0, "length": 353, "protein_name": "Protein arginine N-methyltransferase 1", "gene_name": "Prmt1", "organism": "Rat", "refseq_name": "protein arginine N-methyltransferase 1", "refseq_ac": [ { "id": "NP_077339", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077339", "type": "external" } ], "gene_names_uniprotkb": "Prmt1; Hrmt1l2; Prmt1l1", "gene_names_refseq": "Hrmt1l2; Prmt1", "protein_names_uniprotkb": "Protein arginine N-methyltransferase 1; 2.1.1.319; Histone-arginine N-methyltransferase PRMT1", "protein_names_refseq": "heterogeneous nuclear ribonucleoproteins methyltransferase-like 2; histone-arginine N-methyltransferase PRMT1; protein arginine N-methyltransferase 1", "tax_id": 10116, "disease": "asthma (Disease Ontology:DOID:2841); cleft palate (Disease Ontology:DOID:674)", "pathway": " (rno:60421); (R-RNO-3214858); (R-RNO-8936459); (R-RNO-9009391); (R-RNO-9018519)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "12737817;15837430;18492485;19405910;22095282;31787756;31813251;33826088;34688662;34715362;8663146", "class_list": "", "function": "Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, FMR1, ILF3, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15, EWS, HABP4, SERBP1, RBM15, FOXO1, CHTOP, MAP3K5/ASK1 and MICU1 (PubMed:12737817, PubMed:15837430, PubMed:18492485, PubMed:19405910, PubMed:22095282). Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-3' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation (By similarity). May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway (By similarity). Methylates RBM15, promoting ubiquitination and degradation of RBM15 (By similarity). Methylates MRE11 and TP53BP1, promoting the DNA damage response (By similarity). Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity (By similarity). Methylates CHTOP and this methylation is critical for its 5-hydroxymethylcytosine (5hmC)-binding activity (By similarity). Methylates MAP3K5/ASK1 at 'Arg-85' and 'Arg-87' which promotes association of MAP3K5 with thioredoxin and negatively regulates MAP3K5 association with TRAF2, inhibiting MAP3K5 stimulation and MAP3K5-induced activation of JNK (PubMed:22095282). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (By similarity). Plays a role in regulating alternative splicing in the heart (By similarity). Methylates NPRL2 at 'Arg-78' leading to inhibition of its GTPase activator activity and then the GATOR1 complex and consequently inducing timely mTORC1 activation under methionine-sufficient conditions (By similarity). Methylates the C-terminus of DSP, promoting its phosphorylation by GSK3B and subsequent recruitment to desmosome cell-cell junctions (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Naturally occurring cancer-associated mutations disrupt oligomerization and activity of protein arginine methyltransferase 1 (PRMT1)., [RefSeq, PubMed]; PRMT1 may mediate renal fibroblast activation and renal fibrosis development through activation of the TGF-beta/Smad3 signaling pathway., [RefSeq, PubMed]; PRMT1 promotes extracellular matrix degradation and apoptosis of chondrocytes in temporomandibular joint osteoarthritis via the AKT/FOXO1 signaling pathway., [RefSeq, PubMed]; PRMT1 suppresses ATF4-mediated endoplasmic reticulum response in cardiomyocytes. Erratum:[Cell Death Dis. 2020 Mar 23;11(3):203. doi: 10.1038/s41419-020-2373-8. PMID: 32251281] Publication Status: Online-Only, [RefSeq, PubMed]; Silencing circRNA LRP6 down-regulates PRMT1 to improve the streptozocin-induced pancreatic beta-cell injury and insulin secretion by sponging miR-9-5p., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.1.1.319", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.319", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "2.1.1.321", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.321", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0008170 N-methyltransferase activity;GO:0008276 protein methyltransferase activity;GO:0008327 methyl-CpG binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005765 lysosomal membrane", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0001701 in utero embryonic development;GO:0006338 chromatin remodeling;GO:0008284 positive regulation of cell population proliferation;GO:0031175 neuron projection development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q63009-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXP1-1", "uniprot_id": [ { "id": "CS044_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXP1", "type": "external" } ], "mass": 68244.0, "length": 624, "protein_name": "Uncharacterized protein C19orf44 homolog", "gene_name": "C16h19orf44", "organism": "Rat", "refseq_name": "uncharacterized protein C19orf44 homolog", "refseq_ac": [ { "id": "NP_001013901", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013901", "type": "external" } ], "gene_names_uniprotkb": "C16h19orf44", "gene_names_refseq": "C16h19orf44; RGD1311847", "protein_names_uniprotkb": "Uncharacterized protein C19orf44 homolog", "protein_names_refseq": "uncharacterized protein C19orf44 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:290615)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AXP1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6Q0N0-1", "uniprot_id": [ { "id": "CSTN1_RAT", "url": "https://www.uniprot.org/uniprot/Q6Q0N0", "type": "external" } ], "mass": 106261.0, "length": 952, "protein_name": "Calsyntenin-1", "gene_name": "Clstn1", "organism": "Rat", "refseq_name": "calsyntenin-1 isoform 4 precursor", "refseq_ac": [ { "id": "NP_001007093", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007093", "type": "external" } ], "gene_names_uniprotkb": "Clstn1; Cs1", "gene_names_refseq": "Clstn1", "protein_names_uniprotkb": "Calsyntenin-1; C-terminal fragment 1-alpha", "protein_names_refseq": "alc-alpha; alcadein-alpha; calsyntenin-1 isoform 4 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:313717)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11161476;15326124;16760430;22434822;26479776;39171546", "class_list": "", "function": "As intracellular fragment AlcICD, suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Calsyntenin-1 expression and function in brain tissue of lithium-pilocarpine rat seizure models., [RefSeq, PubMed]; Calsyntenin-1 links a certain type of vesicular and tubulovesicular organelles to the Kinesin-1 motor., [RefSeq, PubMed]; Findings show that amyloid precursor protein (APP) and calsyntenin-1 are co-transported through axons, that loss of calsyntenin-1 disrupts axonal transport of APP and that calsyntenin-1 loss also leads to altered APP processing and increased production of Abeta, [RefSeq, PubMed]; In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Postsynaptic adhesion molecule that binds to presynaptic neurexins to mediate both excitatory and inhibitory synapse formation (By similarity). Promotes synapse development by acting as a cell adhesion molecule at the postsynaptic membrane, which associates with neurexin-alpha at the presynaptic membrane (By similarity). Also functions as a cargo in axonal anterograde transport by acting as a molecular adapter that promotes KLC1 association with vesicles. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001540 amyloid-beta binding;GO:0005509 calcium ion binding;GO:0019894 kinesin binding;GO:0098632 cell-cell adhesion mediator activity;GO:0042988 X11-like protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005634 nucleus", "go_biological_process": "GO:0098969 neurotransmitter receptor transport to postsynaptic membrane;GO:0001558 regulation of cell growth;GO:0051965 positive regulation of synapse assembly;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0090128 regulation of synapse maturation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6Q0N0-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K4C8-1", "uniprot_id": [ { "id": "FZD9_RAT", "url": "https://www.uniprot.org/uniprot/Q8K4C8", "type": "external" } ], "mass": 64965.0, "length": 592, "protein_name": "Frizzled-9", "gene_name": "Fzd9", "organism": "Rat", "refseq_name": "frizzled-9 precursor", "refseq_ac": [ { "id": "NP_695217", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_695217", "type": "external" } ], "gene_names_uniprotkb": "Fzd9", "gene_names_refseq": "Fzd9; rFz9", "protein_names_uniprotkb": "Frizzled-9; Frizzled-like protein 9; rFz9", "protein_names_refseq": "Frizzled-like protein 9; frizzled family receptor 9; frizzled-9 precursor; frizzled-9", "tax_id": 10116, "disease": "Williams-Beuren syndrome (Disease Ontology:DOID:1928)", "pathway": " (rno:266608)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12138115;16670314;27402827;37585277", "class_list": "", "function": "Findings reveal that FZD9 and heterotrimeric G proteins regulate Wnt-5a signaling and dendritic spines in cultured hippocampal neurons., [RefSeq, PubMed]; Frizzled-9 triggers actin polymerization and activates mechano-transducer YAP to rescue simulated microgravity-induced osteoblast dysfunction., [RefSeq, PubMed]; Functions as a Wnt receptor, and is acivated by it, [RefSeq, PubMed]; Receptor for WNT2 that is coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (PubMed:12138115). Plays a role in neuromuscular junction (NMJ) assembly by negatively regulating the clustering of acetylcholine receptors (AChR) through the beta-catenin canonical signaling pathway (By similarity). May play a role in neural progenitor cells (NPCs) viability through the beta-catenin canonical signaling pathway by negatively regulating cell cycle arrest leading to inhibition of neuron apoptotic process (By similarity). During hippocampal development, regulates neuroblast proliferation and apoptotic cell death. Controls bone formation through non canonical Wnt signaling mediated via ISG15. Positively regulates bone regeneration through non canonical Wnt signaling (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0017147 Wnt-protein binding;GO:0042813 Wnt receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0007611 learning or memory;GO:0043524 negative regulation of neuron apoptotic process;GO:0016055 Wnt signaling pathway;GO:0030183 B cell differentiation;GO:0030501 positive regulation of bone mineralization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8K4C8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R2H3-1", "uniprot_id": [ { "id": "BSND_RAT", "url": "https://www.uniprot.org/uniprot/Q8R2H3", "type": "external" } ], "mass": 33895.0, "length": 308, "protein_name": "Barttin", "gene_name": "Bsnd", "organism": "Rat", "refseq_name": "barttin", "refseq_ac": [ { "id": "NP_620435", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620435", "type": "external" } ], "gene_names_uniprotkb": "Bsnd", "gene_names_refseq": "Bsnd", "protein_names_uniprotkb": "Barttin", "protein_names_refseq": "Bartter syndrome, infantile, with sensorineural deafness (Barttin); barttin CLCNK type accessory beta subunit; barttin CLCNK-type chloride channel accessory beta subunit; barttin", "tax_id": 10116, "disease": "Bartter disease type 4a (Disease Ontology:DOID:0110145); sensorineural hearing loss (Disease Ontology:DOID:10003); Bartter disease (Disease Ontology:DOID:445)", "pathway": " (rno:192675); (R-RNO-2672351)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "12111250;12759757;22673903", "class_list": "", "function": "Regulatory subunit of anion-selective CLCNKA:BSND and CLCNKB:BSND heteromeric channels involved in basolateral chloride conductance along the nephron to achieve urine concentration and maintain systemic acid-base homeostasis, and in the stria vascularis of the inner ear to establish the endocochlear potential necessary for normal hearing (By similarity). Most likely acts as a chaperone that allosterically regulates proper sorting of CLCNKA:BSND and CLCNKB:BSND channels at the basolateral plasma membrane domain and functional switch to ion conducting state. Mediates constitutive opening of channel common gates (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017081 chloride channel regulator activity;GO:0005254 chloride channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0007605 sensory perception of sound;GO:0006821 chloride transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8R2H3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EP80-1", "uniprot_id": [ { "id": "PICK1_RAT", "url": "https://www.uniprot.org/uniprot/Q9EP80", "type": "external" } ], "mass": 46606.0, "length": 416, "protein_name": "PRKCA-binding protein", "gene_name": "Pick1", "organism": "Rat", "refseq_name": "PRKCA-binding protein", "refseq_ac": [ { "id": "NP_445912", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445912", "type": "external" } ], "gene_names_uniprotkb": "Pick1; Prkcabp", "gene_names_refseq": "Pick1; Prkcabp", "protein_names_uniprotkb": "PRKCA-binding protein; Protein interacting with C kinase 1; Protein kinase C-alpha-binding protein", "protein_names_refseq": "PRKCA-binding protein; protein interacting with C kinase 1; protein kinase C-alpha-binding protein; protein that interacts with C kinase 1", "tax_id": 10116, "disease": "", "pathway": " (rno:84591); (R-RNO-416993)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "10027300;10340301;11122333;11237868;11375398;11931741;14672991;16138078;17914463;18297063;18429931;19109914;21252856;22673903;23843614;23889934;28855251;28888867;28951554;30605082", "class_list": "", "function": "Multivalent protein-protein and protein-lipid interactions provide critical avidity for the strong binding between the PDZ domain scaffold proteins, PICK1 and PSD-95, and their cognate transmembrane binding partners Publication Status: Online-Only, [RefSeq, PubMed]; PICK1 is a cargo-specific endocytic accessory protein required for efficient, activity-dependent AMPAR endocytosis., [RefSeq, PubMed]; Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Study found that both GluA2 and PICK1 were down-regulated in kainate-treated rats for as long as eight weeks after induction of epilepsy; statistical analysis indicates that the functional role of PIC 1 in studied material is to increase GluA2 concentrations in the cells, [RefSeq, PubMed]; Study shows that oxygen and glucose deprivation (OGD) causes endocytosis, lysosomal targeting and consequent degradation of GluA2- and GluA3-containing AMPARs, and that PICK1 is required for both OGD-induced GluA2 endocytosis and lysosomal sorting. GluA1-containing AMPARs resist OGD-induced endocytosis and PICK1 binding to the endocytic adaptor AP2 is enhanced by OGD in hippocampal, but not cortical neurons. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q546X4;Q925D1", "ec_number_list": [], "go_molecular_function": "GO:0035256 G protein-coupled glutamate receptor binding;GO:0005102 signaling receptor binding;GO:0005543 phospholipid binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098831 presynaptic active zone cytoplasmic component;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0015844 monoamine transport;GO:0021782 glial cell development;GO:0036294 cellular response to decreased oxygen levels;GO:0006468 protein phosphorylation;GO:0006886 intracellular protein transport", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q9EP80-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QY17-1", "uniprot_id": [ { "id": "PACN2_RAT", "url": "https://www.uniprot.org/uniprot/Q9QY17", "type": "external" } ], "mass": 55978.0, "length": 488, "protein_name": "Protein kinase C and casein kinase substrate in neurons 2 protein", "gene_name": "Pacsin2", "organism": "Rat", "refseq_name": "protein kinase C and casein kinase substrate in neurons 2 protein isoform 1", "refseq_ac": [ { "id": "NP_570096", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_570096", "type": "external" } ], "gene_names_uniprotkb": "Pacsin2", "gene_names_refseq": "Pacsin2; SdpII", "protein_names_uniprotkb": "Protein kinase C and casein kinase substrate in neurons 2 protein; SdpII; Synaptic dynamin-associated protein II; Syndapin-2; Syndapin-II", "protein_names_refseq": "SdpIIsyndapin II; protein kinase C and casein kinase substrate in neurons 2 protein isoform 1; protein kinase C and casein kinase substrate in neurons 2 protein; synaptic dynamin-associated protein II; syndapin-2; syndapin-II", "tax_id": 10116, "disease": "Huntington's disease (Disease Ontology:DOID:12858); neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (rno:124461); (R-RNO-8856828)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10704453;12426380;15371016;22673903;22718246;29393594;37296607", "class_list": "", "function": "EHD1 may regulate/participate in the functional pathways of both GS32 and syndapin II in a mutual exclusive manner, [RefSeq, PubMed]; Phosphorylation of PACSIN2 at S313 Regulates Podocyte Architecture in Coordination with N-WASP. Publication Status: Online-Only, [RefSeq, PubMed]; Regulates the morphogenesis and endocytosis of caveolae (PubMed:22718246). Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. Facilitates endothelial front-rear polarity during migration by recruiting EHD4 and MICALL1 to asymmetric adherens junctions between leader and follower cells (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; Syndapins may coordinate N-WASP and dynamin functions during receptor-mediated endocytosis. Local actin polymerization induced by syndapin-N-WASP interactions may support clathrin-coated vesicle detachment and movement away from the plasma membrane., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9QY18;Q9QY19;Q9QY20", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0008289 lipid binding;GO:0008092 cytoskeletal protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome;GO:0005829 cytosol", "go_biological_process": "GO:0072584 caveolin-mediated endocytosis;GO:0045806 negative regulation of endocytosis;GO:0030100 regulation of endocytosis;GO:0030036 actin cytoskeleton organization;GO:0007010 cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9QY17-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0U4-2", "uniprot_id": [ { "id": "GABR1_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z0U4", "type": "external" } ], "mass": 108204.0, "length": 960, "protein_name": "Gamma-aminobutyric acid type B receptor subunit 1", "gene_name": "Gabbr1", "organism": "Rat", "refseq_name": "gamma-aminobutyric acid type B receptor subunit 1 precursor", "refseq_ac": [ { "id": "NP_112290", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112290", "type": "external" } ], "gene_names_uniprotkb": "Gabbr1", "gene_names_refseq": "Gabbr1", "protein_names_uniprotkb": "Gamma-aminobutyric acid type B receptor subunit 1; GABA-B receptor 1; GABA-B-R1; GABA-BR1; GABABR1; Gb1", "protein_names_refseq": "GABA-B receptor 1; GABA-B-R1; GABA-BR1; GABABR1; gamma-aminobutyric acid (GABA) B receptor 1; gamma-aminobutyric acid type B receptor subunit 1 precursor; gb1", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); hypertension (Disease Ontology:DOID:10763); amphetamine abuse (Disease Ontology:DOID:670); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:81657); (R-RNO-1296041); (R-RNO-418594); (R-RNO-420499); (R-RNO-977444); (R-RNO-997272)", "pathway_count": 6, "publication_count": 20, "publication_id_list": "10075644;10457184;10658574;10692480;10727622;10924501;14718537;15304491;22673903;24090084;32651311;32717394;34509561;34830020;38843836;9069281;9872315;9872317;9872744;9875211", "class_list": "", "function": "Component of a heterodimeric G protein-coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:9872315, PubMed:9872317, PubMed:9872744). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed:10658574, PubMed:9872317). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:10075644, PubMed:10924501, PubMed:9872315, PubMed:9872744). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed:10457184, PubMed:10692480, PubMed:10924501, PubMed:9069281, PubMed:9872315, PubMed:9872744). Calcium is required for high affinity binding to GABA (PubMed:10692480). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (PubMed:9872744). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed:10692480, PubMed:10924501, PubMed:9872744). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; GABAB Receptor-Mediated PI3K/Akt Signaling Pathway Alleviates Oxidative Stress and Neuronal Cell Injury in a Rat Model of Alzheimer's Disease., [RefSeq, PubMed]; GABABR Modulation of Electrical Synapses and Plasticity in the Thalamic Reticular Nucleus. Publication Status: Online-Only, [RefSeq, PubMed]; GABABR1 in DRN mediated GABA to regulate 5-HT expression in multiple brain regions in male rats with high and low aggressive behavior., [RefSeq, PubMed]; Presynaptic GABAB receptors underlie the antiepileptic effect of low-frequency electrical stimulation in the 4-aminopyridine model of epilepsy in brain slices of young rats., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 2, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 6, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "O08620;O08621;Q9Z0F9;Q9Z308", "ec_number_list": [], "go_molecular_function": "GO:1990430 extracellular matrix protein binding;GO:0046982 protein heterodimerization activity;GO:0099579 G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential;GO:0004965 G protein-coupled GABA receptor activity;GO:0150047 G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0014048 regulation of glutamate secretion;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007194 negative regulation of adenylate cyclase activity;GO:0008285 negative regulation of cell population proliferation;GO:0035094 response to nicotine", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q9Z0U4-2", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63083-1", "uniprot_id": [ { "id": "NUCB1_RAT", "url": "https://www.uniprot.org/uniprot/Q63083", "type": "external" } ], "mass": 53507.0, "length": 459, "protein_name": "Nucleobindin-1", "gene_name": "Nucb1", "organism": "Rat", "refseq_name": "nucleobindin-1 precursor", "refseq_ac": [ { "id": "NP_445915", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445915", "type": "external" } ], "gene_names_uniprotkb": "Nucb1; Nuc", "gene_names_refseq": "Nucb1; Nucb", "protein_names_uniprotkb": "Nucleobindin-1; Bone 63 kDa calcium-binding protein; CALNUC", "protein_names_refseq": "CALNUC; bone 63 kDa calcium-binding protein; nucleobindin-1 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:84595); (R-RNO-381426); (R-RNO-8957275)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10639138;16641100;20679342;21653697;22673903;23955309;25736948;26666627;7890746;9647645", "class_list": "", "function": "A wide distribution of phoenixin in the hypothalamus which could implicate a potential functional relationship with nesfatin-1, possibly in the regulation of the hypothalamic-pituitary-gonadal axis or other autonomic functions, [RefSeq, PubMed]; Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis (PubMed:7890746). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding proteins (G proteins) (PubMed:21653697)., [UniProtKB, PubMed, PubMed]; Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis. Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding proteins (G proteins)., [UniProtKB, UniProtKB, UniProtKB]; NUCB1 mRNA and protein was found to be present in all brain regions, extending to the spinal cord and dorsal root ganglia; the protein was detected in cell somata and proximal dendrites, but not in axons or terminal structures. Further examination of the subcellular distribution of NUCB1 using organelle-specific markers revealed its consistent presence in the Golgi apparatus., [RefSeq, PubMed]; Nucleobindin 1 is a calcium-regulated guanine nucleotide dissociation inhibitor of G{alpha}i1., [RefSeq, PubMed]; Structural basis for the properties of Calnuc and NUCB2 binding to Galpha subunits and its regulation by calcium ions., [RefSeq, PubMed]; When administrated by injection into the fourth ventricle, nesfatin-1 suppressed food intake in comparison with the control vehicle., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P97623;Q497A4", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0005509 calcium ion binding;GO:0001965 G-protein alpha-subunit binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005798 Golgi-associated vesicle", "go_biological_process": "GO:0007264 small GTPase-mediated signal transduction;GO:1903533 regulation of protein targeting", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q63083-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1H224-1", "uniprot_id": [ { "id": "PWP3A_RAT", "url": "https://www.uniprot.org/uniprot/B1H224", "type": "external" } ], "mass": 77974.0, "length": 698, "protein_name": "PWWP domain-containing DNA repair factor 3A", "gene_name": "Pwwp3a", "organism": "Rat", "refseq_name": "PWWP domain-containing DNA repair factor 3A isoform 2", "refseq_ac": [ { "id": "NP_001426831", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001426831", "type": "external" } ], "gene_names_uniprotkb": "Pwwp3a; Mum1", "gene_names_refseq": "Mum1; Pwwp3a", "protein_names_uniprotkb": "PWWP domain-containing DNA repair factor 3A; MUM-1; Mutated melanoma-associated antigen 1; PWWP domain-containing protein MUM1; PWWP3A", "protein_names_refseq": "MUM-1; PWWP domain-containing DNA repair factor 3A isoform 2; PWWP domain-containing DNA repair factor 3A; PWWP domain-containing protein MUM1; melanoma associated antigen (mutated) 1; melanoma ubiquitous mutated protein; mutated melanoma-associated antigen 1", "tax_id": 10116, "disease": "", "pathway": " (rno:362838)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031491 nucleosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006281 DNA repair;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B1H224-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05546-1", "uniprot_id": [ { "id": "TENR_RAT", "url": "https://www.uniprot.org/uniprot/Q05546", "type": "external" } ], "mass": 149371.0, "length": 1356, "protein_name": "Tenascin-R", "gene_name": "Tnr", "organism": "Rat", "refseq_name": "tenascin-R precursor", "refseq_ac": [ { "id": "NP_037177", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037177", "type": "external" } ], "gene_names_uniprotkb": "Tnr", "gene_names_refseq": "J1NRM; Tnr", "protein_names_uniprotkb": "Tenascin-R; Janusin; Neural recognition molecule J1-160/180; Restrictin; TN-R", "protein_names_refseq": "TN-R; Tenascin-R (Restrictin, janusin, J1-160/180); neural recognition molecule J1-160/180; tenascin R (restrictin, janusin); tenascin-R precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:25567); (R-RNO-3000178)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "10.1039/D0MO00044B;10723065;12393878;14681222;15296743;18658130;19459213;22673903;24090084;28270793;34106099;38843836;7679676;9081628;9294172;9507007;9861042", "class_list": "", "function": "Beta 1 integrin-mediated effects of tenascin-R domains EGFL and FN6-8 on neural stem/progenitor cell proliferation and differentiation in vitro, [RefSeq, PubMed]; Compared tenascin C and tenascin R in oligodendrocyte differentiation. Tnc and Tnr play antagonistic roles for differentiation and comparably inhibit morphologic maturation. conclude that independent molecular pathways regulate these processes., [RefSeq, PubMed]; Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. Theses interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediates inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adhesive properties of TNR over the course of development and during synapse maintenance (By similarity)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 16, "predicted_n_glycosites": 11, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 0, "glyco_site_count": 18, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0009986 cell surface;GO:0031012 extracellular matrix;GO:0045121 membrane raft", "go_biological_process": "GO:0007162 negative regulation of cell adhesion;GO:0007399 nervous system development;GO:0008306 associative learning;GO:0030155 regulation of cell adhesion;GO:0030198 extracellular matrix organization", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q05546-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23385-1", "uniprot_id": [ { "id": "GRM1_RAT", "url": "https://www.uniprot.org/uniprot/P23385", "type": "external" } ], "mass": 133236.0, "length": 1199, "protein_name": "Metabotropic glutamate receptor 1", "gene_name": "Grm1; Lrrc15", "organism": "Rat", "refseq_name": "metabotropic glutamate receptor 1 isoform beta precursor", "refseq_ac": [ { "id": "NP_001107802", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107802", "type": "external" } ], "gene_names_uniprotkb": "Grm1; Lrrc15; Gprc1a; Grm1; Mglur1", "gene_names_refseq": "Gprc1a; Grm1", "protein_names_uniprotkb": "Metabotropic glutamate receptor 1; mGluR1", "protein_names_refseq": "G protein coupled receptor family C group 1 member A; glutamate receptor, metabotropic 1; mGluR1; metabotropic glutamate receptor 1 isoform beta precursor; metabotropic glutamate receptor 1", "tax_id": 10116, "disease": "autosomal recessive spinocerebellar ataxia 13 (Disease Ontology:DOID:0080062); spinocerebellar ataxia 44 (Disease Ontology:DOID:0080286); temporal lobe epilepsy (Disease Ontology:DOID:3328); uveal melanoma (Disease Ontology:DOID:6039); skin melanoma (Disease Ontology:DOID:8923)", "pathway": " (rno:24414); (rno:246296); (R-RNO-416476); (R-RNO-420499); (R-RNO-6794361)", "pathway_count": 5, "publication_count": 15, "publication_id_list": "10469171;10945991;11069170;11850456;11867751;1309649;1438218;1656524;1847995;22673903;35046120;35798932;37622292;37714421;37909134", "class_list": "", "function": "Activation of adenosine A1 receptor potentiates metabotropic glutamate receptor 1-mediated Ca[2+] mobilization in the rat hippocampal marginal zone., [RefSeq, PubMed]; Amygdala Metabotropic Glutamate Receptor 1 Influences Synaptic Transmission to Participate in Fentanyl-Induced Hyperalgesia in Rats., [RefSeq, PubMed]; G protein-coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum (PubMed:10945991, PubMed:1438218, PubMed:1656524, PubMed:1847995). May function in the light response in the retina (By similarity). Induces GRID1 and GRID2 cation-channel activation via GNAQ-PLC-PKC pathway in dopaminergic neurons and cerebellar Purkinje cell, respectively (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, UniProtKB]; MGluR1/IP3/ERK signaling pathway regulates vestibular compensation in ON UBCs of the cerebellar flocculus., [RefSeq, PubMed]; Stabilization of Spine Synaptopodin by mGluR1 Is Required for mGluR-LTD., [RefSeq, PubMed]; [Activation of metabotropic glutamate receptor 1 inhibits chronic intermittent hypoxia-induced carotid body plasticity in rats]., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001639 PLC activating G protein-coupled glutamate receptor activity;GO:0001640 adenylate cyclase inhibiting G protein-coupled glutamate receptor activity;GO:0099530 G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential;GO:0004930 G protein-coupled receptor activity;GO:0030331 nuclear estrogen receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0030424 axon", "go_biological_process": "GO:0007206 phospholipase C-activating G protein-coupled glutamate receptor signaling pathway;GO:0014048 regulation of glutamate secretion;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007626 locomotory behavior;GO:0019722 calcium-mediated signaling", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P23385-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.1000000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2LC84-1", "uniprot_id": [ { "id": "NUMB_RAT", "url": "https://www.uniprot.org/uniprot/Q2LC84", "type": "external" } ], "mass": 70596.0, "length": 652, "protein_name": "Protein numb homolog", "gene_name": "Numb", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Numb", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein numb homolog", "protein_names_refseq": "", "tax_id": 10116, "disease": "brain cancer (Disease Ontology:DOID:1319)", "pathway": " (rno:29419); (R-RNO-437239); (R-RNO-5610780); (R-RNO-5632684)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "17022975;22673903", "class_list": "", "function": "Plays a role in the process of neurogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Regulates clathrin-mediated receptor endocytosis (By similarity). Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2GVA9;F1MAI8", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding;GO:0045294 alpha-catenin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005886 plasma membrane", "go_biological_process": "GO:0007399 nervous system development;GO:0007409 axonogenesis;GO:0030100 regulation of endocytosis;GO:0030154 cell differentiation;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q2LC84-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O55170-1", "uniprot_id": [ { "id": "SOX10_RAT", "url": "https://www.uniprot.org/uniprot/O55170", "type": "external" } ], "mass": 50039.0, "length": 466, "protein_name": "Transcription factor SOX-10", "gene_name": "Sox10", "organism": "Rat", "refseq_name": "transcription factor SOX-10", "refseq_ac": [ { "id": "NP_062066", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062066", "type": "external" } ], "gene_names_uniprotkb": "Sox10", "gene_names_refseq": "Sox10", "protein_names_uniprotkb": "Transcription factor SOX-10", "protein_names_refseq": "SRY (sex determining region Y)-box 10; SRY box 10; SRY-box containing gene 10; transcription factor SOX-10", "tax_id": 10116, "disease": "PCWH syndrome (Disease Ontology:DOID:0090111); Waardenburg syndrome type 4C (Disease Ontology:DOID:0110955); Waardenburg syndrome type 2E (Disease Ontology:DOID:0110956); Hirschsprung's disease (Disease Ontology:DOID:10487); Kallmann syndrome (Disease Ontology:DOID:3614); Waardenburg syndrome (Disease Ontology:DOID:9258)", "pathway": " (rno:29361); (R-RNO-9856649)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "26525805;29130118;32362205;32428246;32908618;38791273;9412504", "class_list": "", "function": "HNK1 and Sox10 are present during repair of mandibular bone defects., [RefSeq, PubMed]; Oxaliplatin-induced neuropathic pain involves HOXA6 via a TET1-dependent demethylation of the SOX10 promoter. Erratum:[Int J Cancer. 2021 Sep 15;149(6):E10. doi: 10.1002/ijc.33718. PMID: 34196406], [RefSeq, PubMed]; Sox10 Activity and the Timing of Schwann Cell Differentiation Are Controlled by a Tle4-Dependent Negative Feedback Loop. Publication Status: Online-Only, [RefSeq, PubMed]; Sox10 Is a Specific Biomarker for Neural Crest Stem Cells in Immunohistochemical Staining in Wistar Rats. Publication Status: Online-Only, [RefSeq, PubMed]; The present study identified that one of the lineages of S100beta-positive cells is a SOX10-positive one and that SOX10-positive cells express pituitary stem/progenitor cell marker genes. Erratum:[Cell Tissue Res. 2018 Apr;372(1):161-162. doi: 10.1007/s00441-018-2816-z. PMID: 29480457], [RefSeq, PubMed]; Transcription factor that plays a central role in developing and mature glia (By similarity). Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination (By similarity). Once induced, MYRF cooperates with SOX10 to implement the myelination program (By similarity). Transcriptional activator of MITF, acting synergistically with PAX3 (By similarity). Transcriptional activator of MBP, via binding to the gene promoter (PubMed:26525805)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005741 mitochondrial outer membrane;GO:0000785 chromatin", "go_biological_process": "GO:0048484 enteric nervous system development;GO:0071393 cellular response to progesterone stimulus;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O55170-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16290-1", "uniprot_id": [ { "id": "PGAM2_RAT", "url": "https://www.uniprot.org/uniprot/P16290", "type": "external" } ], "mass": 28755.0, "length": 253, "protein_name": "Phosphoglycerate mutase 2", "gene_name": "Pgam2", "organism": "Rat", "refseq_name": "phosphoglycerate mutase 2", "refseq_ac": [ { "id": "NP_059024", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059024", "type": "external" } ], "gene_names_uniprotkb": "Pgam2", "gene_names_refseq": "D14Mgh1; PGAM-M; Pgam2; Pgmut", "protein_names_uniprotkb": "Phosphoglycerate mutase 2; 5.4.2.11; 5.4.2.4; BPG-dependent PGAM 2; Muscle-specific phosphoglycerate mutase; PGAM-M; Phosphoglycerate mutase isozyme M", "protein_names_refseq": "BPG-dependent PGAM 2; isozyme MM; muscle-specific phosphoglycerate mutase; phosphoglycerate mutase 2 (muscle); phosphoglycerate mutase 2; phosphoglycerate mutase isozyme M; type MM phosphoglycerate mutase", "tax_id": 10116, "disease": "myoglobinuria (Disease Ontology:DOID:0080108)", "pathway": " (rno:24959); (R-RNO-70171); (R-RNO-70263)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "22673903;2558656;34502162;7926808", "class_list": "", "function": "Catalyzes the interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the interconversion of (2R)-2,3-bisphosphoglycerate and (2R)-3-phospho-glyceroyl phosphate, but with a reduced activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" } ], "go_molecular_function": "GO:0004082 bisphosphoglycerate mutase activity;GO:0004619 phosphoglycerate mutase activity;GO:0016787 hydrolase activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:1990917 ooplasm", "go_biological_process": "GO:0007219 Notch signaling pathway;GO:0007283 spermatogenesis;GO:0006094 gluconeogenesis;GO:0006096 glycolytic process;GO:0006941 striated muscle contraction", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P16290-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35465-1", "uniprot_id": [ { "id": "PAK1_RAT", "url": "https://www.uniprot.org/uniprot/P35465", "type": "external" } ], "mass": 60578.0, "length": 544, "protein_name": "Serine/threonine-protein kinase PAK 1", "gene_name": "Pak1", "organism": "Rat", "refseq_name": "serine/threonine-protein kinase PAK 1", "refseq_ac": [ { "id": "NP_058894", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058894", "type": "external" } ], "gene_names_uniprotkb": "Pak1", "gene_names_refseq": "Pak1", "protein_names_uniprotkb": "Serine/threonine-protein kinase PAK 1; 2.7.11.1; Alpha-PAK; PAK-1; Protein kinase MUK2; p21-activated kinase 1; p68-PAK", "protein_names_refseq": "PAK-1; alpha-PAK; p21 (CDKN1A)-activated kinase 1; p21 protein (Cdc42/Rac)-activated kinase 1; p21-activated kinase 1; p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related); p68-PAK; protein kinase MUK2; serine/threonine-protein kinase PAK 1", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061); Alzheimer's disease (Disease Ontology:DOID:10652); breast cancer (Disease Ontology:DOID:1612); nephroblastoma (Disease Ontology:DOID:2154); brain ischemia (Disease Ontology:DOID:2316); transitional cell carcinoma (Disease Ontology:DOID:2671); ovarian carcinoma (Disease Ontology:DOID:4001); renal cell carcinoma (Disease Ontology:DOID:4450); schizophrenia (Disease Ontology:DOID:5419); uveal melanoma (Disease Ontology:DOID:6039)", "pathway": " (rno:29431); (R-RNO-202433); (R-RNO-2029482); (R-RNO-2871796); (R-RNO-389359); (R-RNO-3928662); (R-RNO-3928664); (R-RNO-399954); (R-RNO-445144); (R-RNO-445355); (R-RNO-5218920); (R-RNO-5621575); (R-RNO-5627123); (R-RNO-5687128); (R-RNO-8964616); (R-RNO-9013149); (R-RNO-9013404); (R-RNO-9013406); (R-RNO-9013407); (R-RNO-9013420); (R-RNO-9013423); (R-RNO-9013424)", "pathway_count": 22, "publication_count": 21, "publication_id_list": "10802735;11278486;12876277;14707132;15542607;19029984;22669945;22673903;24089484;25284783;28408623;28972183;31587871;31868209;36938611;7559638;8107774;9032240;9528787;9601050;9774440", "class_list": "", "function": "MiRNA-221 regulates proliferation, apoptosis and insulin secretion in islet beta cells through targeting PAK1, thus protecting gestational diabetes mellitus -induced islet dysfunction in a rat model, [RefSeq, PubMed]; PAK-mediated phosphorylation of PKD1 at Ser203 triggers its membrane dissociation and subsequent entry into the nucleus, thereby regulating the phosphorylation of PKD1 nuclear targets, including class IIa histone deacetylases., [RefSeq, PubMed]; Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes (PubMed:12876277, PubMed:14707132, PubMed:19029984, PubMed:9032240, PubMed:9528787). Can directly phosphorylate BAD and protects cells against apoptosis (By similarity). Activated by interaction with CDC42 and RAC1 (PubMed:9528787). Functions as a GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway (PubMed:9528787). Phosphorylates and activates MAP2K1, and thereby mediates activation of downstream MAP kinases (PubMed:12876277, PubMed:19029984, PubMed:9032240, PubMed:9528787). Involved in the reorganization of the actin cytoskeleton, actin stress fibers and of focal adhesion complexes (PubMed:9774440). Phosphorylates the tubulin chaperone TBCB and thereby plays a role in the regulation of microtubule biogenesis and organization of the tubulin cytoskeleton (By similarity). Plays a role in the regulation of insulin secretion in response to elevated glucose levels (By similarity). Part of a ternary complex that contains PAK1, DVL1 and MUSK that is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By similarity). Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2 (By similarity). Phosphorylates MYL9/MLC2 (By similarity). Phosphorylates RAF1 at 'Ser-338' and 'Ser-339' resulting in: activation of RAF1, stimulation of RAF1 translocation to mitochondria, phosphorylation of BAD by RAF1, and RAF1 binding to BCL2 (By similarity). Phosphorylates SNAI1 at 'Ser-246' promoting its transcriptional repressor activity by increasing its accumulation in the nucleus (By similarity). In podocytes, promotes NR3C2 nuclear localization (PubMed:19029984). Required for atypical chemokine receptor ACKR2-induced phosphorylation of LIMK1 and cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (By similarity). In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3, maybe through CFL1 phosphorylation and inactivation (PubMed:24089484). Plays a role in RUFY3-mediated facilitating gastric cancer cells migration and invasion (By similarity). In response to DNA damage, phosphorylates MORC2 which activates its ATPase activity and facilitates chromatin remodeling (By similarity). In neurons, plays a crucial role in regulating GABA(A) receptor synaptic stability and hence GABAergic inhibitory synaptic transmission through its role in F-actin stabilization (PubMed:25284783). In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity). Along with GIT1, positively regulates microtubule nucleation during interphase (By similarity). Phosphorylates FXR1, promoting its localization to stress granules and activity (By similarity). Phosphorylates ILK on 'Thr-173' and 'Ser-246', promoting nuclear export of ILK (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, UniProtKB]; Rac1/PAK1 signaling contributes to bone cancer pain by Regulation dendritic spine remodeling in rats. Erratum:[Mol Pain. 2023 Jan-Dec;19:17448069231182501. doi: 10.1177/17448069231182501. PMID: 37608691], [RefSeq, PubMed]; These results expand the model of insulin-stimulated glucose uptake in skeletal muscle cells by implicating p41ARC as a new component of the insulin-signaling cascade and connecting PAK1 signaling to N-WASP-cortactin-mediated actin polymerization and GLUT4 vesicle translocation., [RefSeq, PubMed]; Up-regulation of P21-activated kinase 1 in osteoarthritis chondrocytes is responsible for osteoarthritic cartilage destruction., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 31, "reported_mutagensis": 11, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q62934", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, 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"external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "1.16.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.1.-", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "1.6.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.13", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development;GO:0050770 regulation of axonogenesis;GO:0060244 negative regulation of cell proliferation involved in contact inhibition;GO:1903608 protein localization to cytoplasmic stress granule;GO:0006338 chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P35465-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62796-1", "uniprot_id": [ { "id": "RBP1_RAT", "url": "https://www.uniprot.org/uniprot/Q62796", "type": "external" } ], "mass": 75252.0, "length": 647, "protein_name": "RalA-binding protein 1", "gene_name": "Ralbp1", "organism": "Rat", "refseq_name": "ralA-binding protein 1", "refseq_ac": [ { "id": "NP_114456", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114456", "type": "external" } ], "gene_names_uniprotkb": "Ralbp1", "gene_names_refseq": "RIP1; RLIP76; Ralbp1", "protein_names_uniprotkb": "RalA-binding protein 1; 7.6.2.2; 7.6.2.3; Cytocentrin; DNP-SG ATPase; Dinitrophenyl S-glutathione ATPase; Ral-interacting protein 1; RalBP1", "protein_names_refseq": "DNP-SG ATPase; cytocentrin; dinitrophenyl S-glutathione ATPase; ral-interacting protein 1; ralA-binding protein 1", "tax_id": 10116, "disease": "microphthalmia (Disease Ontology:DOID:10629); urinary bladder cancer (Disease Ontology:DOID:11054); pancreatic adenocarcinoma (Disease Ontology:DOID:4074)", "pathway": " (rno:84014); (R-RNO-9013148); (R-RNO-9013149)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10393179;22673903;28252651;28395284;28579326;33629276;33828080;7623849;9395447;9422736;9973605", "class_list": "", "function": "Could also function as a primary ATP-dependent active transporter for glutathione conjugates of electrophiles. May also actively catalyze the efflux of a wide range of substrates including xenobiotics like doxorubicin (DOX) contributing to cell multidrug resistance., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Genetic inactivation of RIP1 kinase activity in rats protects against ischemic brain injury. Publication Status: Online-Only, [RefSeq, PubMed]; Multifunctional protein that functions as a downstream effector of RALA and RALB. As a GTPase-activating protein/GAP can inactivate CDC42 and RAC1 by stimulating their GTPase activity (PubMed:7623849, PubMed:9422736). As part of the Ral signaling pathway, may also regulate ligand-dependent EGF and insulin receptors-mediated endocytosis (PubMed:10393179). During mitosis, may act as a scaffold protein in the phosphorylation of EPSIN/EPN1 by the mitotic kinase cyclin B-CDK1, preventing endocytosis during that phase of the cell cycle. During mitosis, also controls mitochondrial fission as an effector of RALA. Recruited to mitochondrion by RALA, acts as a scaffold to foster the mitotic kinase cyclin B-CDK1-mediated phosphorylation and activation of DNM1L (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Phosphorylation of RIP1 is the essential molecular mechanism of necroptosis. Publication Status: Online-Only, [RefSeq, PubMed]; Subarachnoid hemorrhage led to the upregulation of RIP1, RIP3, phosphorylated DRP1 and NLRP3 inflammasome Erratum:[Exp Neurol. 2024 Jul;377:114787. doi: 10.1016/j.expneurol.2024.114787. PMID: 38653705], [RefSeq, PubMed]; The Key Regulator of Necroptosis, RIP1 Kinase, Contributes to the Formation of Astrogliosis and Glial Scar in Ischemic Stroke., [RefSeq, PubMed]; These results demonstrated that indole-3-carbinol could induce apoptosis of hepatic stellate cells through RIP1 K63 de-ubiquitination by upregulating deubiquitinase CYLD., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O55195", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" } ], "go_molecular_function": "GO:0042910 xenobiotic transmembrane transporter activity;GO:0005096 GTPase activator activity;GO:0005524 ATP binding;GO:0022857 transmembrane transporter activity;GO:0042626 ATPase-coupled transmembrane transporter activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0006897 endocytosis;GO:0043547 positive regulation of GTPase activity;GO:0051301 cell division;GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q62796-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U2Y8-1", "uniprot_id": [ { "id": "TEX44_RAT", "url": "https://www.uniprot.org/uniprot/Q5U2Y8", "type": "external" } ], "mass": 46510.0, "length": 436, "protein_name": "Testis-expressed protein 44", "gene_name": "Tex44", "organism": "Rat", "refseq_name": "testis-expressed protein 44", "refseq_ac": [ { "id": "NP_001019535", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019535", "type": "external" } ], "gene_names_uniprotkb": "Tex44", "gene_names_refseq": "Tex44", "protein_names_uniprotkb": "Testis-expressed protein 44", "protein_names_refseq": "testis-expressed protein 44; uncharacterized protein C2orf57 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:501180)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5U2Y8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62829-1", "uniprot_id": [ { "id": "PAK3_RAT", "url": "https://www.uniprot.org/uniprot/Q62829", "type": "external" } ], "mass": 60711.0, "length": 544, "protein_name": "Serine/threonine-protein kinase PAK 3", "gene_name": "Pak3", "organism": "Rat", "refseq_name": "serine/threonine-protein kinase PAK 3", "refseq_ac": [ { "id": "NP_062083", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062083", "type": "external" } ], "gene_names_uniprotkb": "Pak3", "gene_names_refseq": "Pak3; beta-PAK", "protein_names_uniprotkb": "Serine/threonine-protein kinase PAK 3; 2.7.11.1; Beta-PAK; PAK-3; p21-activated kinase 3; p65-PAK", "protein_names_refseq": "PAK-3; p21 (CDKN1A)-activated kinase 3; p21 protein (Cdc42/Rac)-activated kinase 3; p21-activated kinase 3; p21/Cdc42/Rac1-activated kinase 3 (yeast Ste20-related); p65-PAK; serine/threonine-protein kinase PAK 3", "tax_id": 10116, "disease": "non-syndromic X-linked intellectual disability 30 (Disease Ontology:DOID:0112051)", "pathway": " (rno:29433); (R-RNO-202433); (R-RNO-389359); (R-RNO-3928664); (R-RNO-399954); (R-RNO-5218920); (R-RNO-5621575); (R-RNO-5627123); (R-RNO-5687128); (R-RNO-9013149); (R-RNO-9013420)", "pathway_count": 11, "publication_count": 7, "publication_id_list": "11278486;12890786;22238087;22673903;23818969;26460013;7559638", "class_list": "", "function": "PAK3 regulates activity-mediated rearrangement of synaptic connectivity associated with learning, suggesting that defects in spine formation and refinement during development could account for intellectual disability., [RefSeq, PubMed]; Results show elevated PAK3 expression at both the mRNA and protein level in cJun/AP-1-over-expressing Rat1a fibroblasts, as well as in transformed human fibroblasts. Publication Status: Online-Only, [RefSeq, PubMed]; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as a downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development (PubMed:12890786). In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity)., [UniProtKB, UniProtKB, PubMed]; Specific loss of PAK3 expression and pharmacological inhibition of PAK both disrupt activity-dependent phosphorylation of S863 in cortical neurons, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "1.6.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.-", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0017124 SH3 domain binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0014069 postsynaptic density", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0006468 protein phosphorylation;GO:0007409 axonogenesis;GO:0016358 dendrite development;GO:0016477 cell migration", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q62829-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63481-1", "uniprot_id": [ { "id": "RAB7L_RAT", "url": "https://www.uniprot.org/uniprot/Q63481", "type": "external" } ], "mass": 23117.0, "length": 204, "protein_name": "Ras-related protein Rab-29", "gene_name": "Rab29", "organism": "Rat", "refseq_name": "ras-related protein Rab-29", "refseq_ac": [ { "id": "NP_598274", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598274", "type": "external" } ], "gene_names_uniprotkb": "Rab29; Rab7l1", "gene_names_refseq": "Rab29; Rab7l1", "protein_names_uniprotkb": "Ras-related protein Rab-29; 3.6.5.2; Rab-7-like protein 1; Ras-related protein Rab-7L1", "protein_names_refseq": "RAB7, member RAS oncogene family-like 1; Ras-related GTP-binding protein Rab29; rab-7-like protein 1; ras-related protein Rab-29; ras-related protein Rab-7L1", "tax_id": 10116, "disease": "", "pathway": " (rno:171122); (R-RNO-8873719)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "23395371;32691280;9177482", "class_list": "", "function": "RAB7L1 Participates in Secondary Brain Injury Induced by Experimental Intracerebral Hemorrhage in Rats., [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:23395371). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB29 is essential for maintaining the integrity of endosome-trans-Golgi network structure (PubMed:23395371). Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Recruits LRRK2 to the Golgi apparatus and stimulates LRRK2 kinase activity (By similarity). Stimulates phosphorylation of RAB10 'Thr-73' by LRRK2 (By similarity). Also regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:23395371)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0019209 kinase activator activity;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0097708 intracellular vesicle;GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005769 early endosome", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0030154 cell differentiation;GO:0090316 positive regulation of intracellular protein transport;GO:0042110 T cell activation;GO:0009617 response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q63481-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64232-1", "uniprot_id": [ { "id": "TECR_RAT", "url": "https://www.uniprot.org/uniprot/Q64232", "type": "external" } ], "mass": 36123.0, "length": 308, "protein_name": "Very-long-chain enoyl-CoA reductase", "gene_name": "Tecr", "organism": "Rat", "refseq_name": "very-long-chain enoyl-CoA reductase isoform 1", "refseq_ac": [ { "id": "NP_612558", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612558", "type": "external" } ], "gene_names_uniprotkb": "Tecr; Gpsn2; Tecrl2", "gene_names_refseq": "Gpsn2; SC2; Tecr", "protein_names_uniprotkb": "Very-long-chain enoyl-CoA reductase; 1.3.1.93; Synaptic glycoprotein SC2; TER; Trans-2,3-enoyl-CoA reductase", "protein_names_refseq": "TER; glycoprotein, synaptic 2; neuroprotective protein 13; synaptic glycoprotein SC2; very-long-chain enoyl-CoA reductase isoform 1; very-long-chain enoyl-CoA reductase", "tax_id": 10116, "disease": "non-syndromic intellectual disability (Disease Ontology:DOID:0050889); autosomal recessive intellectual developmental disorder 14 (Disease Ontology:DOID:0081188)", "pathway": " (rno:191576); (R-RNO-75876)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "1404491;22673903;29393594;38843836", "class_list": "", "function": "Involved in both the production of very long-chain fatty acids for sphingolipid synthesis and the degradation of the sphingosine moiety in sphingolipids through the sphingosine 1-phosphate metabolic pathway (By similarity). Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle (By similarity). This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle (By similarity). This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation (By similarity). Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators (By similarity). Catalyzes the saturation step of the sphingosine 1-phosphate metabolic pathway, the conversion of trans-2-hexadecenoyl-CoA to palmitoyl-CoA (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.3.1.93", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.93", "type": "external" } ], "go_molecular_function": "GO:0102758 very-long-chain enoyl-CoA reductase activity;GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "GO:0006665 sphingolipid metabolic process;GO:0006694 steroid biosynthetic process;GO:0030497 fatty acid elongation;GO:0042761 very long-chain fatty acid biosynthetic process;GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q64232-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8QZV1-1", "uniprot_id": [ { "id": "PDE9A_RAT", "url": "https://www.uniprot.org/uniprot/Q8QZV1", "type": "external" } ], "mass": 61756.0, "length": 534, "protein_name": "High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A", "gene_name": "Pde9a", "organism": "Rat", "refseq_name": "high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A", "refseq_ac": [ { "id": "NP_612552", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612552", "type": "external" } ], "gene_names_uniprotkb": "Pde9a", "gene_names_refseq": "Pde9a", "protein_names_uniprotkb": "High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A; 3.1.4.35", "protein_names_refseq": "high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A", "tax_id": 10116, "disease": "Huntington's disease (Disease Ontology:DOID:12858); dilated cardiomyopathy (Disease Ontology:DOID:12930); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (rno:191569); (R-RNO-418457)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11698617;14501210;16641100;18674549;19445908;22070409;22328573", "class_list": "", "function": "Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP. Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart. Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein (By similarity). In brain, involved in cognitive function, such as learning and long-term memory (PubMed:18674549, PubMed:22070409, PubMed:22328573)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; We here present, for the first time, the expression of PDE9A, PDE10A, and PDE11A in the trigeminovascular system; localisation indicates that they may have a role in pain pathways, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1LRG6", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.1.4.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.17", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.25", "type": "external" }, { "id": "3.6.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.14", "type": "external" }, { "id": "3.1.4.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.53", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity;GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0043204 perikaryon", "go_biological_process": "GO:0007165 signal transduction;GO:1900273 positive regulation of long-term synaptic potentiation;GO:0010613 positive regulation of cardiac muscle hypertrophy;GO:2000178 negative regulation of neural precursor cell proliferation;GO:0046068 cGMP metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8QZV1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WUD2-1", "uniprot_id": [ { "id": "TRPV2_RAT", "url": "https://www.uniprot.org/uniprot/Q9WUD2", "type": "external" } ], "mass": 86706.0, "length": 761, "protein_name": "Transient receptor potential cation channel subfamily V member 2", "gene_name": "Trpv2", "organism": "Rat", "refseq_name": "transient receptor potential cation channel subfamily V member 2", "refseq_ac": [ { "id": "NP_001257726", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257726", "type": "external" } ], "gene_names_uniprotkb": "Trpv2; Sac2b; Vrl1", "gene_names_refseq": "Trpv2; Vrl1", "protein_names_uniprotkb": "Transient receptor potential cation channel subfamily V member 2; OTRPC2; Osm-9-like TRP channel 2; Stretch-activated channel 2B; TrpV2; VRL-1; Vanilloid receptor-like protein 1", "protein_names_refseq": "OTRPC2; VRL-1; osm-9-like TRP channel 2; stretch-activated channel 2B; transient receptor potential cation channel subfamily V member 2; vanilloid receptor-like protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:29465); (R-RNO-3295583)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10201375;12228246;14622291;14991772;15249591;16809337;22673903;36134661;36470868;37608122;38728789;38776831;39972168", "class_list": "", "function": "Calcium-permeable, non-selective cation channel (PubMed:10201375, PubMed:15249591, PubMed:39972168). Seems to be regulated, at least in part, by growth factors, such as IGF1, PDGF and morphogenetic neuropeptide/head activator (By similarity). May transduce physical stimuli in mast cells (PubMed:15249591)., [UniProtKB, PubMed, UniProtKB, PubMed]; Cannabinoid non-cannabidiol site modulation of TRPV2 structure and function. Publication Status: Online-Only, [RefSeq, PubMed]; Key amino acids, Arg-114 and Glu-761, in the N- and C-cytosolic tails, respectively, that determine ligand binding were determined in VRL1, [RefSeq, PubMed]; Loss of TRPV2-mediated blood flow autoregulation recapitulates diabetic retinopathy in rats. Publication Status: Online-Only, [RefSeq, PubMed]; Protective role of TRPV2 in synaptic plasticity through the ERK1/2-CREB-BDNF pathway in chronic unpredictable mild stress rats., [RefSeq, PubMed]; The dynamic TRPV2 ion channel proximity proteome reveals functional links of calcium flux with cellular adhesion factors NCAM and L1CAM in neurite outgrowth., [RefSeq, PubMed]; The role of TRPV2 as a regulator on the osteoclast differentiation during orthodontic tooth movement in rats. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q5FWT3;Q9JMI8;Q9QYH8", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0005261 monoatomic cation channel activity", "go_cellular_component": "GO:0032584 growth cone membrane;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030027 lamellipodium;GO:0030424 axon", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0009266 response to temperature stimulus;GO:0045773 positive regulation of axon extension;GO:0090280 positive regulation of calcium ion import;GO:0098703 calcium ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9WUD2-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38445-1", "uniprot_id": [ { "id": "AVR2B_RAT", "url": "https://www.uniprot.org/uniprot/P38445", "type": "external" } ], "mass": 57857.0, "length": 513, "protein_name": "Activin receptor type-2B", "gene_name": "Acvr2b", "organism": "Rat", "refseq_name": "activin receptor type-2B precursor", "refseq_ac": [ { "id": "NP_113742", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113742", "type": "external" } ], "gene_names_uniprotkb": "Acvr2b; Actriib", "gene_names_refseq": "Acvr2b", "protein_names_uniprotkb": "Activin receptor type-2B; 2.7.11.30; ACTR-IIB; Activin receptor type IIB", "protein_names_refseq": "ACTR-IIB; ActRIIB type II activin receptor B; Activine receptor 2b (transmembrane serine kinase); activin A receptor, type IIB; activin receptor IIB; activin receptor type IIB; activin receptor type-2B precursor; activin receptor type-2B", "tax_id": 10116, "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545); juvenile polyposis syndrome (Disease Ontology:DOID:0050787); visceral heterotaxy 4 (Disease Ontology:DOID:0051019); right atrial isomerism (Disease Ontology:DOID:0060856); pre-eclampsia (Disease Ontology:DOID:10591); Marfan syndrome (Disease Ontology:DOID:14323)", "pathway": " (rno:25366); (R-RNO-1502540); (R-RNO-201451)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "12660162;1312838;31315975;7916681", "class_list": "", "function": "The structure of an activin class member, GDF11, in complex with the type II receptor ActRIIB and the type I receptor Alk5, is reported., [RefSeq, PubMed]; Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q4V8J8", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.11.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.30", "type": "external" } ], "go_molecular_function": "GO:0019209 kinase activator activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019838 growth factor binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0048179 activin receptor complex;GO:0032991 protein-containing complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006468 protein phosphorylation;GO:0007165 signal transduction;GO:0007507 heart development;GO:0001822 kidney development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P38445-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1000000001000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ES54-1", "uniprot_id": [ { "id": "NPL4_RAT", "url": "https://www.uniprot.org/uniprot/Q9ES54", "type": "external" } ], "mass": 68056.0, "length": 608, "protein_name": "Nuclear protein localization protein 4 homolog", "gene_name": "Nploc4", "organism": "Rat", "refseq_name": "nuclear protein localization protein 4 homolog", "refseq_ac": [ { "id": "NP_542144", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_542144", "type": "external" } ], "gene_names_uniprotkb": "Nploc4; Npl4", "gene_names_refseq": "Npl4; Nploc4", "protein_names_uniprotkb": "Nuclear protein localization protein 4 homolog; Protein NPL4", "protein_names_refseq": "homolog of yeast nuclear protein localization 4; nuclear protein localization 4 homolog; nuclear protein localization protein 4 homolog", "tax_id": 10116, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (rno:140639); (R-RNO-110320); (R-RNO-8951664); (R-RNO-9755511)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "10811609;11740563;11781570;12411482;12644454;14636562", "class_list": "", "function": "The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (PubMed:10811609, PubMed:11740563, PubMed:11781570, PubMed:12411482, PubMed:12644454, PubMed:14636562). Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T1J3", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0051117 ATPase binding;GO:0031625 ubiquitin protein ligase binding;GO:0044877 protein-containing complex binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0036501 UFD1-NPL4 complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0036503 ERAD pathway;GO:0007030 Golgi organization;GO:0030970 retrograde protein transport, ER to cytosol", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9ES54-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4FZU8-1", "uniprot_id": [ { "id": "RIPR1_RAT", "url": "https://www.uniprot.org/uniprot/Q4FZU8", "type": "external" } ], "mass": 131731.0, "length": 1217, "protein_name": "Rho family-interacting cell polarization regulator 1", "gene_name": "Ripor1", "organism": "Rat", "refseq_name": "rho family-interacting cell polarization regulator 1", "refseq_ac": [ { "id": "NP_001094130", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094130", "type": "external" } ], "gene_names_uniprotkb": "Ripor1; Fam65a", "gene_names_refseq": "Fam65a; RGD1307772; Ripor1", "protein_names_uniprotkb": "Rho family-interacting cell polarization regulator 1", "protein_names_refseq": "family with sequence similarity 65, member A; protein FAM65A; rho family-interacting cell polarization regulator 1", "tax_id": 10116, "disease": "", "pathway": " (rno:291974)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Downstream effector protein for Rho-type small GTPases that plays a role in cell polarity and directional migration. Acts as an adapter protein, linking active Rho proteins to STK24 and STK26 kinases, and hence positively regulates Golgi reorientation in polarized cell migration upon Rho activation. Involved in the subcellular relocation of STK26 from the Golgi to cytoplasm punctae in a Rho- and PDCD10-dependent manner upon serum stimulation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0071889 14-3-3 protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0016020 membrane;GO:0031252 cell leading edge", "go_biological_process": "GO:1990869 cellular response to chemokine;GO:0030335 positive regulation of cell migration;GO:0090316 positive regulation of intracellular protein transport;GO:0007266 Rho protein signal transduction;GO:0009611 response to wounding", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4FZU8-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26284-1", "uniprot_id": [ { "id": "ODPA_RAT", "url": "https://www.uniprot.org/uniprot/P26284", "type": "external" } ], "mass": 43227.0, "length": 390, "protein_name": "Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial", "gene_name": "Pdha1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pdha1; Pdha1l1", "gene_names_refseq": "", "protein_names_uniprotkb": "Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; 1.2.4.1; PDHE1-A type I", "protein_names_refseq": "", "tax_id": 10116, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); pyruvate decarboxylase deficiency (Disease Ontology:DOID:3649); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (rno:29554); (R-RNO-204174); (R-RNO-5362517); (R-RNO-9861559)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "16396499;16641100;18683930;19341700;2025639;22673903;27213235;8158120", "class_list": "", "function": "The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Together with PDHB forms the heterotetrameric E1 subunit of the pyruvate dehydrogenase (PDH) complex. The PDH complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links cytoplasmic glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and dihydrolipoamide dehydrogenase (E3). The E1 subunit catalyzes both the thiamine pyrophosphate (TPP)-dependent decarboxylation of pyruvate and the reductive acetylation of a lipoyl group covalently linked to the lipoyl-bearing domains of E2., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "3.1.3.43", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.43", "type": "external" }, { "id": "2.3.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.12", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0032991 protein-containing complex;GO:0045254 pyruvate dehydrogenase complex", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006006 glucose metabolic process;GO:0006086 pyruvate decarboxylation to acetyl-CoA", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P26284-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P86410-1", "uniprot_id": [ { "id": "RLGPB_RAT", "url": "https://www.uniprot.org/uniprot/P86410", "type": "external" } ], "mass": 165367.0, "length": 1484, "protein_name": "Ral GTPase-activating protein subunit beta", "gene_name": "Ralgapb", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ralgapb", "gene_names_refseq": "", "protein_names_uniprotkb": "Ral GTPase-activating protein subunit beta; p170", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "19520869;22673903", "class_list": "", "function": "Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "", "go_biological_process": "GO:0051056 regulation of small GTPase mediated signal transduction;GO:0032880 regulation of protein localization;GO:0090630 activation of GTPase activity;GO:0060178 regulation of exocyst localization;GO:0032484 Ral protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P86410-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U2Z7-1", "uniprot_id": [ { "id": "RHG24_RAT", "url": "https://www.uniprot.org/uniprot/Q5U2Z7", "type": "external" } ], "mass": 84144.0, "length": 748, "protein_name": "Rho GTPase-activating protein 24", "gene_name": "Arhgap24", "organism": "Rat", "refseq_name": "rho GTPase-activating protein 24 isoform 1", "refseq_ac": [ { "id": "NP_001380749", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001380749", "type": "external" } ], "gene_names_uniprotkb": "Arhgap24; DR-NR#2", "gene_names_refseq": "Arhgap24; DR-NR#2", "protein_names_uniprotkb": "Rho GTPase-activating protein 24; Down-regulated in nephrectomized rat kidney #2; Rho-type GTPase-activating protein 24", "protein_names_refseq": "Down-regulated in nephrectomized rat kidney #2; rho GTPase-activating protein 24 isoform 1; rho GTPase-activating protein 24; rho-type GTPase-activating protein 24", "tax_id": 10116, "disease": "", "pathway": " (rno:305156); (R-RNO-8980692); (R-RNO-9013148); (R-RNO-9013149)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "15200410;22673903;38421271", "class_list": "", "function": "FilGAP controls cell-extracellular matrix adhesion and process formation of kidney podocytes., [RefSeq, PubMed]; Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6I7R2", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005912 adherens junction;GO:0005925 focal adhesion;GO:0042995 cell projection", "go_biological_process": "GO:1900028 negative regulation of ruffle assembly;GO:0001525 angiogenesis;GO:0007165 signal transduction;GO:0030154 cell differentiation;GO:0035313 wound healing, spreading of epidermal cells", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5U2Z7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K4S7-1", "uniprot_id": [ { "id": "CBLB_RAT", "url": "https://www.uniprot.org/uniprot/Q8K4S7", "type": "external" } ], "mass": 104652.0, "length": 938, "protein_name": "E3 ubiquitin-protein ligase CBL-B", "gene_name": "Cblb", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase CBL-B isoform 1", "refseq_ac": [ { "id": "NP_598285", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598285", "type": "external" } ], "gene_names_uniprotkb": "Cblb", "gene_names_refseq": "Cblb", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase CBL-B; 2.3.2.27; Casitas B-lineage lymphoma proto-oncogene b; RING-type E3 ubiquitin transferase CBL-B; SH3-binding protein CBL-B; Signal transduction protein CBL-B", "protein_names_refseq": "Cas-Br-M (murine) ecotropic retroviral transforming sequence b; Casitas B-lineage lymphoma b; Cbl proto-oncogene B, E3 ubiquitin protein ligase; Cbl proto-oncogene, E3 ubiquitin protein ligase B; E3 ubiquitin-protein ligase CBL-B isoform 1; E3 ubiquitin-protein ligase CBL-B; RING-type E3 ubiquitin transferase CBL-B; SH3-binding protein CBL-B; casitas B-lineage lymphoma proto-oncogene b; signal transduction protein CBL-B", "tax_id": 10116, "disease": "infantile onset multisystem autoimmune disease 3 (Disease Ontology:DOID:0061162); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); stomach carcinoma (Disease Ontology:DOID:5517); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:171136); (R-RNO-983168)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "12118252;12231245;14525909;14604964;16641100;22673903;29513566;30021515;32606037", "class_list": "", "function": "C-Cbl protooncogene product is tyrosine- phosphorylated in rat cerebellum in response to ethanol administration., [RefSeq, PubMed]; CAP-Cbl pathway may have a role in the modulation of adiposity in fasting and in monosodium glutamate treated rats., [RefSeq, PubMed]; E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Results suggest that ubiquitin and the E3 ubiquitin ligases c-Cbl and Cbl-b function as neuroimmune modulators in the subacute phase of neuropathic pain after nerve injury. Publication Status: Online-Only, [RefSeq, PubMed]; Ubiquitination and functional modification of GluN2B subunit-containing NMDA receptors by Cbl-b in the spinal cord dorsal horn. Publication Status: Online-Only, [RefSeq, PubMed]; Under microgravity conditions, elevated ROS may be a crucial mechanotransducer in skeletal muscle cells, regulating muscle mass through Cbl-b expression activated by the ERK-Egr signaling pathway., [RefSeq, PubMed]; We report the positional cloning of Iddm/kdp1 and identify a nonsense mutation in Cblb, a member of the Cbl/Sli family of ubiquitin-protein ligases.Cblb is a major susceptibility gene for rat type 1 diabetes mellitus, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9QZ69", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" } ], "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0008270 zinc ion binding;GO:0019901 protein kinase binding;GO:0005509 calcium ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0045121 membrane raft;GO:0098794 postsynapse", "go_biological_process": "GO:0006955 immune response;GO:0007165 signal transduction;GO:0030155 regulation of cell adhesion;GO:0035556 intracellular signal transduction;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8K4S7-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CGS5-1", "uniprot_id": [ { "id": "RNZ2_RAT", "url": "https://www.uniprot.org/uniprot/Q8CGS5", "type": "external" } ], "mass": 92340.0, "length": 827, "protein_name": "Zinc phosphodiesterase ELAC protein 2", "gene_name": "Elac2", "organism": "Rat", "refseq_name": "zinc phosphodiesterase ELAC protein 2", "refseq_ac": [ { "id": "NP_758829", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_758829", "type": "external" } ], "gene_names_uniprotkb": "Elac2", "gene_names_refseq": "Elac2", "protein_names_uniprotkb": "Zinc phosphodiesterase ELAC protein 2; 3.1.26.11; ElaC homolog protein 2; RNase Z 2; Ribonuclease Z 2; tRNA 3 endonuclease 2; tRNase Z 2", "protein_names_refseq": "RNase Z 2; elaC homolog 2; elaC homolog protein 2; ribonuclease Z 2; tRNA 3 endonuclease 2; tRNase Z 2; zinc phosphodiesterase ELAC protein 2", "tax_id": 10116, "disease": "mitochondrial complex I deficiency (Disease Ontology:DOID:0060536); combined oxidative phosphorylation deficiency 17 (Disease Ontology:DOID:0111496); infantile hypertrophic cardiomyopathy (Disease Ontology:DOID:0111753); prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (rno:282826)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15358515;22673903", "class_list": "", "function": "Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0042781 3'-tRNA processing endoribonuclease activity;GO:0004549 tRNA-specific ribonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0042780 tRNA 3'-end processing;GO:1990180 mitochondrial tRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8CGS5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P85125-1", "uniprot_id": [ { "id": "CAVN1_RAT", "url": "https://www.uniprot.org/uniprot/P85125", "type": "external" } ], "mass": 43909.0, "length": 392, "protein_name": "Caveolae-associated protein 1", "gene_name": "Cavin1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cavin1; Ptrf", "gene_names_refseq": "", "protein_names_uniprotkb": "Caveolae-associated protein 1; Cavin-1; Polymerase I and transcript release factor; cav-p60", "protein_names_refseq": "", "tax_id": 10116, "disease": "congenital generalized lipodystrophy type 4 (Disease Ontology:DOID:0111138); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (rno:287710); (R-RNO-73863); (R-RNO-8980692); (R-RNO-9013026); (R-RNO-9013106)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "11512676;11702238;16236245;18056712;22673903;29393594", "class_list": "", "function": "Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues. Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1). Essential for normal oligomerization of CAV1. Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop. Dissociates transcription complexes paused by DNA-bound TTF1, thereby releasing both RNA polymerase I and pre-RNA from the template. The caveolae biogenesis pathway is required for the secretion of proteins such as GASK1A., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 21, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042134 rRNA primary transcript binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0009303 rRNA transcription;GO:0009306 protein secretion;GO:2000147 positive regulation of cell motility;GO:0006361 transcription initiation at RNA polymerase I promoter;GO:0006363 termination of RNA polymerase I transcription", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P85125-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKL7-1", "uniprot_id": [ { "id": "SREK1_RAT", "url": "https://www.uniprot.org/uniprot/Q9JKL7", "type": "external" } ], "mass": 56849.0, "length": 494, "protein_name": "Splicing regulatory glutamine/lysine-rich protein 1", "gene_name": "Srek1", "organism": "Rat", "refseq_name": "splicing regulatory glutamine/lysine-rich protein 1 isoform 2", "refseq_ac": [ { "id": "NP_064477", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064477", "type": "external" } ], "gene_names_uniprotkb": "Srek1; Sfrs12; Srrp86", "gene_names_refseq": "Sfrs12; Srek1; Srrp86; Srsf12", "protein_names_uniprotkb": "Splicing regulatory glutamine/lysine-rich protein 1; SR-related protein of 86 kDa; SRrp86; Serine/arginine-rich-splicing regulatory protein 86; Splicing factor, arginine/serine-rich 12", "protein_names_refseq": "SR-related protein of 86 kDa; serine/arginine-rich splicing factor 12; serine/arginine-rich-splicing regulatory protein 86; splicing factor, arginine/serine-rich 12; splicing regulatory glutamic acid/lysine-rich protein 1; splicing regulatory glutamine/lysine-rich protein 1 isoform 2; splicing regulatory glutamine/lysine-rich protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:56763)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10757789;11991645", "class_list": "", "function": "Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9JKL7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23606-1", "uniprot_id": [ { "id": "TGM1_RAT", "url": "https://www.uniprot.org/uniprot/P23606", "type": "external" } ], "mass": 90770.0, "length": 824, "protein_name": "Protein-glutamine gamma-glutamyltransferase K", "gene_name": "Tgm1", "organism": "Rat", "refseq_name": "protein-glutamine gamma-glutamyltransferase K isoform 1", "refseq_ac": [ { "id": "NP_113847", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113847", "type": "external" } ], "gene_names_uniprotkb": "Tgm1", "gene_names_refseq": "Tgm1", "protein_names_uniprotkb": "Protein-glutamine gamma-glutamyltransferase K; 2.3.2.13; Epidermal TGase; TG(K); TGK; TGase K; TGase-1; Transglutaminase K; Transglutaminase-1", "protein_names_refseq": "TG(K); TGK; TGase K; TGase-1; epidermal TGase; protein-glutamine gamma-glutamyltransferase K isoform 1; protein-glutamine gamma-glutamyltransferase K; transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase); transglutaminase 1, K polypeptide; transglutaminase K", "tax_id": 10116, "disease": "autosomal recessive congenital ichthyosis 1 (Disease Ontology:DOID:0060656)", "pathway": " (rno:60335); (R-RNO-6809371)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "1979171;22573678;22673903;25599570", "class_list": "", "function": "Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Expression, activity, and functionality of TG1 and TG2 are decreased in the aorta, but not in the vena cava, from hypertensive rats., [RefSeq, PubMed]; Forced expression of TG1 or TG2 proteins is sufficient to induce neuronal death in Rattus norvegicus cortical neurons in vitro. Erratum:[J Neurosci. 2012 Aug 8;32(32):11157], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4QRA6", "ec_number_list": [ { "id": "2.3.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.13", "type": "external" }, { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.5.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.44", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0003810 protein-glutamine gamma-glutamyltransferase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0016020 membrane", "go_biological_process": "GO:0030216 keratinocyte differentiation;GO:0009887 animal organ morphogenesis;GO:0018149 peptide cross-linking;GO:0045787 positive regulation of cell cycle;GO:0010838 positive regulation of keratinocyte proliferation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P23606-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52759-1", "uniprot_id": [ { "id": "RIDA_RAT", "url": "https://www.uniprot.org/uniprot/P52759", "type": "external" } ], "mass": 14303.0, "length": 137, "protein_name": "2-iminobutanoate/2-iminopropanoate deaminase", "gene_name": "Rida", "organism": "Rat", "refseq_name": "2-iminobutanoate/2-iminopropanoate deaminase", "refseq_ac": [ { "id": "NP_113902", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113902", "type": "external" } ], "gene_names_uniprotkb": "Rida; Psp1", "gene_names_refseq": "Hrsp12; L-PSP; PSP1; Psp; Rida; rp14.5", "protein_names_uniprotkb": "2-iminobutanoate/2-iminopropanoate deaminase; 3.5.99.10; L-PSP; Liver perchloric acid-soluble protein; Reactive intermediate imine deaminase A homolog; Translation inhibitor L-PSP ribonuclease; UK114 antigen homolog; rp14.5", "protein_names_refseq": "14.5 kDa translational inhibitor protein; 2-iminobutanoate/2-iminopropanoate deaminase; UK114 antigen homolog; heat-responsive protein 12; liver perchloric acid-soluble protein; perchloric acid-soluble protein; perchrolic acid soluble protein; reactive intermediate imine deaminase A homolog; ribonuclease UK114; translation inhibitor L-PSP ribonuclease", "tax_id": 10116, "disease": "", "pathway": " (rno:65151); (R-RNO-8849175)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10400702;11003673;17416349;22801372;8385007;8530410", "class_list": "", "function": "Also promotes endoribonucleolytic cleavage of some transcripts by promoting recruitment of the ribonuclease P/MRP complex (PubMed:10400702). Acts by bridging YTHDF2 and the ribonuclease P/MRP complex (By similarity). RIDA/HRSP12 binds to N6-methyladenosine (m6A)-containing mRNAs containing a 5'-GGUUC-3' motif: cooperative binding of RIDA/HRSP12 and YTHDF2 to such transcripts lead to recruitment of the ribonuclease P/MRP complex and subsequent endoribonucleolytic cleavage (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These studies define new roles for glucocorticoid receptor, Y-box binding protein 1, and RNase UK114 in the formation of a molecular complex that degrades MCP-1 mRNA., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35262;Q9WUV8", "ec_number_list": [ { "id": "3.5.99.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.99.10", "type": "external" } ], "go_molecular_function": "GO:0036041 long-chain fatty acid binding;GO:0003729 mRNA binding;GO:0042802 identical protein binding;GO:0046914 transition metal ion binding;GO:0019239 deaminase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005777 peroxisome", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0001822 kidney development;GO:0030324 lung development;GO:0050680 negative regulation of epithelial cell proliferation;GO:0033993 response to lipid", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P52759-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61314-1", "uniprot_id": [ { "id": "RL15_RAT", "url": "https://www.uniprot.org/uniprot/P61314", "type": "external" } ], "mass": 24146.0, "length": 204, "protein_name": "Large ribosomal subunit protein eL15", "gene_name": "Rpl15l2; Rpl15l3; Rpl15", "organism": "Rat", "refseq_name": "large ribosomal subunit protein eL15", "refseq_ac": [ { "id": "NP_620814", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620814", "type": "external" } ], "gene_names_uniprotkb": "Rpl15l2; Rpl15l3; Rpl15; LOC100362479; RGD1565767; Rpl15l1; Rpl15l3; Rpl15", "gene_names_refseq": "Rpl10; Rpl15", "protein_names_uniprotkb": "Large ribosomal subunit protein eL15; 60S ribosomal protein L15", "protein_names_refseq": "60S ribosomal protein L15; large ribosomal subunit protein eL15", "tax_id": 10116, "disease": "Diamond-Blackfan anemia 12 (Disease Ontology:DOID:0111882)", "pathway": " (rno:100362479); (rno:245981); (rno:311120); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72689); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954709); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 13, "publication_count": 2, "publication_id_list": "22673903;8198562", "class_list": "", "function": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P39030;P41051;Q96C44;Q9H2E5", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0045202 synapse;GO:0022626 cytosolic ribosome;GO:0031672 A band", "go_biological_process": "GO:0045471 response to ethanol;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P61314-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4G055-1", "uniprot_id": [ { "id": "RNPC3_RAT", "url": "https://www.uniprot.org/uniprot/Q4G055", "type": "external" } ], "mass": 58037.0, "length": 515, "protein_name": "RNA-binding region-containing protein 3", "gene_name": "Rnpc3", "organism": "Rat", "refseq_name": "RNA-binding region-containing protein 3", "refseq_ac": [ { "id": "NP_001094280", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094280", "type": "external" } ], "gene_names_uniprotkb": "Rnpc3; Rbm40", "gene_names_refseq": "Rnpc3", "protein_names_uniprotkb": "RNA-binding region-containing protein 3; RNA-binding motif protein 40; RNA-binding protein 40", "protein_names_refseq": "RNA-binding motif protein 40; RNA-binding protein 40; RNA-binding region-containing protein 3", "tax_id": 10116, "disease": "combined or isolated pituitary growth hormone deficiency 7 (Disease Ontology:DOID:0061016)", "pathway": " (rno:691538); (R-RNO-72165)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'-stem-loop of m(7)G-capped U12 snRNA (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0097157 pre-mRNA intronic binding;GO:0030626 U12 snRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0034693 U11/U12 snRNP;GO:0005689 U12-type spliceosomal complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4G055-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U2Y6-1", "uniprot_id": [ { "id": "TFP11_RAT", "url": "https://www.uniprot.org/uniprot/Q5U2Y6", "type": "external" } ], "mass": 96152.0, "length": 837, "protein_name": "Tuftelin-interacting protein 11", "gene_name": "Tfip11", "organism": "Rat", "refseq_name": "tuftelin-interacting protein 11", "refseq_ac": [ { "id": "NP_001008292", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008292", "type": "external" } ], "gene_names_uniprotkb": "Tfip11; Srrd; Stip", "gene_names_refseq": "Tfip11", "protein_names_uniprotkb": "Tuftelin-interacting protein 11; STIP-1; Septin and tuftelin-interacting protein 1", "protein_names_refseq": "STIP-1; septin and tuftelin-interacting protein 1; tuftelin-interacting protein 11", "tax_id": 10116, "disease": "", "pathway": " (rno:288718); (R-RNO-72163)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "17289020;22673903;29393594", "class_list": "", "function": "Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0031012 extracellular matrix;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0031333 negative regulation of protein-containing complex assembly;GO:0031214 biomineral tissue development;GO:0000390 spliceosomal complex disassembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5U2Y6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63584-1", "uniprot_id": [ { "id": "TMEDA_RAT", "url": "https://www.uniprot.org/uniprot/Q63584", "type": "external" } ], "mass": 24858.0, "length": 219, "protein_name": "Transmembrane emp24 domain-containing protein 10", "gene_name": "Tmed10", "organism": "Rat", "refseq_name": "transmembrane emp24 domain-containing protein 10 precursor", "refseq_ac": [ { "id": "NP_445919", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445919", "type": "external" } ], "gene_names_uniprotkb": "Tmed10; Tmp21", "gene_names_refseq": "Tmed10; Tmp21", "protein_names_uniprotkb": "Transmembrane emp24 domain-containing protein 10; 21 kDa transmembrane-trafficking protein; Protein Tmed10; Transmembrane protein Tmp21; p24 family protein delta-1; p24delta1", "protein_names_refseq": "21 kDa transmembrane-trafficking protein; integral membrane protein Tmp21-I (p23); p24 family protein delta-1; p24delta1; transmembrane emp24 domain-containing protein 10 precursor; transmembrane emp24 domain-containing protein 10; transmembrane emp24-like trafficking protein 10; transmembrane protein Tmp21; transmembrane trafficking protein 21", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (rno:84599); (R-RNO-204005); (R-RNO-5694530); (R-RNO-6807878); (R-RNO-6811434)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "10214941;10376215;11703931;15047867;15718469;18627576;21545355;24271503;27569046;8663407;9472029", "class_list": "", "function": "Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi (By similarity). The p24 protein family is a group of transmembrane proteins that bind coat protein complex I/COPI and coat protein complex II/COPII involved in vesicular trafficking between the membranes (By similarity). Acts at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and involved in vesicle coat formation at the cytoplasmic side (PubMed:10214941). Mainly functions in the early secretory pathway and cycles between the ER, ER-Golgi intermediate compartment (ERGIC) and Golgi, mediating cargo transport through COPI and COPII-coated vesicles (PubMed:10214941). In COPII vesicle-mediated anterograde transport, involved in the transport of GPI-anchored proteins by acting together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER (PubMed:27569046). Recognizes GPI anchors structural remodeled in the ER by the GPI inositol-deacylase/PGAP1 and the metallophosphoesterase MPPE1/PGAP5 (PubMed:27569046). In COPI vesicle-mediated retrograde transport, involved in the biogenesis of COPI vesicles and vesicle coat recruitment. Involved in trafficking of amyloid beta A4 protein and soluble APP-beta release (independent from the modulation of gamma-secretase activity) (By similarity). Involved in the KDELR2-mediated retrograde transport of the toxin A subunit (CTX-A-K63)together with COPI and the COOH terminus of KDELR2 (By similarity). On Golgi membranes, acts as a primary receptor for ARF1-GDP, a GTP-binding protein involved in COPI-vesicle formation. Increases coatomer-dependent GTPase-activating activity of ARFGAP2 which mediates the hydrolysis of ARF1-bound GTP and therefore modulates protein trafficking from the Golgi apparatus. Involved in the exocytic trafficking of G protein-coupled receptors F2LR1/PAR2 (trypsin and tryspin-like enzyme receptor), OPRM1 (opioid receptor) and P2RY4 (UTD and UDP receptor) from the Golgi to the plasma membrane, thus contributing to receptor resensitization. In addition to its cargo receptor activity, may also act as a protein channel after oligomerization, facilitating the post-translational entry of leaderless cytoplasmic cargo into the ERGIC. Involved in the translocation into ERGIC, the vesicle entry and the secretion of leaderless cargos (lacking the secretion signal sequence), including the mature form of interleukin 1/IL-1 family members, the alpha-crystallin B chain HSPB5, the carbohydrate-binding proteins galectin-1/LGALS1 and galectin-3/LGALS3, the microtubule-associated protein Tau/MAPT, and the annexin A1/ANXA1; the translocation process is dependent on cargo protein unfolding and enhanced by chaperones HSP90AB1 and HSP90B1/GRP9. Could also associates with the presenilin-dependent gamma-secretase complex in order to regulate gamma-cleavages of the amyloid beta A4 protein to yield amyloid-beta 40/Abeta40 (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed]; Chondrocyte-associated antigen Tmp21 may be considered a chondrocyte differentiation antigen, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9R0W6", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0019905 syntaxin binding;GO:0008320 protein transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0043279 response to alkaloid;GO:0006886 intracellular protein transport;GO:0045055 regulated exocytosis;GO:0001822 kidney development;GO:0050714 positive regulation of protein secretion", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q63584-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66H73-1", "uniprot_id": [ { "id": "CCD82_RAT", "url": "https://www.uniprot.org/uniprot/Q66H73", "type": "external" } ], "mass": 60069.0, "length": 516, "protein_name": "Coiled-coil domain-containing protein 82", "gene_name": "Ccdc82", "organism": "Rat", "refseq_name": "coiled-coil domain-containing protein 82", "refseq_ac": [ { "id": "NP_001007661", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007661", "type": "external" } ], "gene_names_uniprotkb": "Ccdc82", "gene_names_refseq": "Ccdc82", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 82", "protein_names_refseq": "coiled-coil domain-containing protein 82", "tax_id": 10116, "disease": "", "pathway": " (rno:300359)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q66H73-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WUV6-1", "uniprot_id": [ { "id": "CAZA3_RAT", "url": "https://www.uniprot.org/uniprot/Q9WUV6", "type": "external" } ], "mass": 35007.0, "length": 299, "protein_name": "F-actin-capping protein subunit alpha-3", "gene_name": "Capza3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Capza3", "gene_names_refseq": "", "protein_names_uniprotkb": "F-actin-capping protein subunit alpha-3; CapZ alpha-3", "protein_names_refseq": "", "tax_id": 10116, "disease": "male infertility (Disease Ontology:DOID:12336)", "pathway": " (rno:29324)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;9406198", "class_list": "", "function": "F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the morphogenesis of spermatid., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0003779 actin binding", "go_cellular_component": "GO:0061827 sperm head;GO:0016020 membrane;GO:0008290 F-actin capping protein complex;GO:0001669 acrosomal vesicle;GO:0030863 cortical cytoskeleton", "go_biological_process": "GO:0007015 actin filament organization;GO:0007286 spermatid development;GO:0030036 actin cytoskeleton organization;GO:0051016 barbed-end actin filament capping;GO:0007028 cytoplasm organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9WUV6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1H9-1", "uniprot_id": [ { "id": "CAVN3_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z1H9", "type": "external" } ], "mass": 27910.0, "length": 263, "protein_name": "Caveolae-associated protein 3", "gene_name": "Cavin3", "organism": "Rat", "refseq_name": "caveolae-associated protein 3", "refseq_ac": [ { "id": "NP_604444", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_604444", "type": "external" } ], "gene_names_uniprotkb": "Cavin3; Dig2; Prkcdbp; Srbc", "gene_names_refseq": "Cavin3; DIG-2; Prkcdbp; Srbc", "protein_names_uniprotkb": "Caveolae-associated protein 3; Cavin-3; D3T-inducible gene 2 protein; DIG-2; Dithiolethione-inducible gene 2 protein; Protein kinase C delta-binding protein; Serum deprivation response factor-related gene product that binds to C-kinase", "protein_names_refseq": "D3T-inducible gene 2 protein; PKC-delta binding protein; caveolae-associated protein 3; cavin-3; dithiolethione-inducible gene 2 protein; dithiolethione-inducible gene-2; protein kinase C, delta binding protein; sdr-elated gene product that binds to c-kinase; serum deprivation response factor-related gene product that binds to C-kinase", "tax_id": 10116, "disease": "", "pathway": " (rno:85332)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15197346;22673903;29393594;8968041;9054438", "class_list": "", "function": "Regulates the traffic and/or budding of caveolae. Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells. Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by promoting the rapid release of caveolae from the cell surface. Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2 (By similarity). Seems to have an immune potentiation function, especially in the glioma (PubMed:15197346)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P97585", "ec_number_list": [], "go_molecular_function": "GO:0005080 protein kinase C binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005901 caveola;GO:0032991 protein-containing complex", "go_biological_process": "GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0001558 regulation of cell growth;GO:0030866 cortical actin cytoskeleton organization;GO:0032922 circadian regulation of gene expression;GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9Z1H9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17267-1", "uniprot_id": [ { "id": "IF_RAT", "url": "https://www.uniprot.org/uniprot/P17267", "type": "external" } ], "mass": 45956.0, "length": 417, "protein_name": "Cobalamin binding intrinsic factor", "gene_name": "Cblif", "organism": "Rat", "refseq_name": "cobalamin binding intrinsic factor precursor", "refseq_ac": [ { "id": "NP_058858", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058858", "type": "external" } ], "gene_names_uniprotkb": "Cblif; Gif", "gene_names_refseq": "Cblif; Gif", "protein_names_uniprotkb": "Cobalamin binding intrinsic factor; Gastric intrinsic factor; IF; INF; Intrinsic factor", "protein_names_refseq": "IF; INF; cobalamin binding intrinsic factor precursor; gastric intrinsic factor; intrinsic factor", "tax_id": 10116, "disease": "congenital intrinsic factor deficiency (Disease Ontology:DOID:0050734); gastric ulcer (Disease Ontology:DOID:10808); pernicious anemia (Disease Ontology:DOID:13381); gastritis (Disease Ontology:DOID:4029)", "pathway": " (rno:29319); (R-RNO-9758881)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "22673903;3422425;7490275", "class_list": "", "function": "Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis (By similarity)., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "O35801", "ec_number_list": [], "go_molecular_function": "GO:0019842 vitamin binding;GO:0031419 cobalamin binding;GO:0140355 cargo receptor ligand activity;GO:0140104 molecular carrier activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005768 endosome;GO:0016324 apical plasma membrane;GO:0005902 microvillus", "go_biological_process": "GO:0015889 cobalamin transport;GO:0006824 cobalt ion transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P17267-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIB2-1", "uniprot_id": [ { "id": "CWC27_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIB2", "type": "external" } ], "mass": 53310.0, "length": 468, "protein_name": "Spliceosome-associated protein CWC27 homolog", "gene_name": "Cwc27", "organism": "Rat", "refseq_name": "spliceosome-associated protein CWC27 homolog", "refseq_ac": [ { "id": "NP_001013217", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013217", "type": "external" } ], "gene_names_uniprotkb": "Cwc27; Sdccag10", "gene_names_refseq": "Cwc27; Sdccag10", "protein_names_uniprotkb": "Spliceosome-associated protein CWC27 homolog; PPIase CWC27; Probable inactive peptidyl-prolyl cis-trans isomerase CWC27 homolog", "protein_names_refseq": "CWC27 spliceosome-associated protein homolog; PPIase CWC27; PPIase SDCCAG10; peptidyl-prolyl cis-trans isomerase CWC27 homolog; peptidyl-prolyl cis-trans isomerase SDCCAG10; probable inactive peptidyl-prolyl cis-trans isomerase CWC27 homolog; serologically defined colon cancer antigen 10; spliceosome-associated protein CWC27 homolog", "tax_id": 10116, "disease": "retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (rno:361887); (R-RNO-72163)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "As part of the spliceosome, plays a role in pre-mRNA splicing. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005681 spliceosomal complex;GO:0071013 catalytic step 2 spliceosome;GO:0071005 U2-type precatalytic spliceosome", "go_biological_process": "GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XIB2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80WE1-1", "uniprot_id": [ { "id": "FMR1_RAT", "url": "https://www.uniprot.org/uniprot/Q80WE1", "type": "external" } ], "mass": 66780.0, "length": 593, "protein_name": "Fragile X messenger ribonucleoprotein 1", "gene_name": "Fmr1", "organism": "Rat", "refseq_name": "fragile X messenger ribonucleoprotein 1 isoform 2", "refseq_ac": [ { "id": "NP_434691", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_434691", "type": "external" } ], "gene_names_uniprotkb": "Fmr1", "gene_names_refseq": "FMRP; Fmr1", "protein_names_uniprotkb": "Fragile X messenger ribonucleoprotein 1; FMRP; Fragile X messenger ribonucleoprotein", "protein_names_refseq": "FMRP translational regulator 1; fragile X messenger ribonucleoprotein 1 isoform 2; protein FMR-1; synaptic functional regulator FMR1", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); fragile X-associated tremor/ataxia syndrome (Disease Ontology:DOID:0050879); withdrawal disorder (Disease Ontology:DOID:0060001); autism spectrum disorder (Disease Ontology:DOID:0060041); myoclonic-atonic epilepsy (Disease Ontology:DOID:0060475); warfarin resistance (Disease Ontology:DOID:0080665); primary ovarian insufficiency 1 (Disease Ontology:DOID:0080857); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); fragile X syndrome (Disease Ontology:DOID:14261); alcohol use disorder (Disease Ontology:DOID:1574); transient cerebral ischemia (Disease Ontology:DOID:224); glucose metabolism disease (Disease Ontology:DOID:4194); hyperglycemia (Disease Ontology:DOID:4195); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); malignant pleural mesothelioma (Disease Ontology:DOID:7474); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (rno:24948)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "14613971;15028757;15564573;16098134;16571602;16641100;18683930;20512134;23891804;24709664;36581671;36849416;38378836;9030614;9144248", "class_list": "", "function": "FMR1 deletion in rats induces hyperactivity with no changes in striatal dopamine transporter availability. Publication Status: Online-Only, [RefSeq, PubMed]; Multi-level profiling of the Fmr1 KO rat unveils altered behavioral traits along with aberrant glutamatergic function. Publication Status: Online-Only, [RefSeq, PubMed]; Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of target mRNAs (PubMed:9144248). Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (By similarity). Plays a role in the alternative splicing of its own mRNA (By similarity). Stabilizes the scaffolding postsynaptic density protein DLG4/PSD-95 and the myelin basic protein (MBP) mRNAs in hippocampal neurons and glial cells, respectively; this stabilization is further increased in response to metabotropic glutamate receptor (mGluR) stimulation (By similarity). Plays a role in selective delivery of a subset of dendritic mRNAs to synaptic sites in response to mGluR activation in a kinesin-dependent manner (By similarity). Undergoes liquid-liquid phase separation following phosphorylation and interaction with CAPRIN1, promoting formation of cytoplasmic ribonucleoprotein granules that concentrate mRNAs with factors that inhibit translation and mediate deadenylation of target mRNAs. Acts as a repressor of mRNA translation in synaptic regions by mediating formation of neuronal ribonucleoprotein granules and promoting recruitmtent of EIF4EBP2. Plays a role as a repressor of mRNA translation during the transport of dendritic mRNAs to postsynaptic dendritic spines (PubMed:9144248). Component of the CYFIP1-EIF4E-FMR1 complex which blocks cap-dependent mRNA translation initiation (By similarity). Represses mRNA translation by stalling ribosomal translocation during elongation (By similarity). Reports are contradictory with regards to its ability to mediate translation inhibition of MBP mRNA in oligodendrocytes. Also involved in the recruitment of the RNA helicase MOV10 to a subset of mRNAs and hence regulates microRNA (miRNA)-mediated translational repression by AGO2. Facilitates the assembly of miRNAs on specific target mRNAs. Also plays a role as an activator of mRNA translation of a subset of dendritic mRNAs at synapses (By similarity). In response to mGluR stimulation, FMR1-target mRNAs are rapidly derepressed, allowing for local translation at synapses (By similarity). Binds to a large subset of dendritic mRNAs that encode a myriad of proteins involved in pre- and postsynaptic functions. Binds to 5'-ACU[GU]-3' and/or 5'-[AU]GGA-3' RNA consensus sequences within mRNA targets, mainly at coding sequence (CDS) and 3'-untranslated region (UTR) and less frequently at 5'-UTR. Binds to intramolecular G-quadruplex structures in the 5'- or 3'-UTRs of mRNA targets. Binds to G-quadruplex structures in the 3'-UTR of its own mRNA. Also binds to RNA ligands harboring a kissing complex (kc) structure; this binding may mediate the association of FMR1 with polyribosomes. Binds mRNAs containing U-rich target sequences. Binds to a triple stem-loop RNA structure, called Sod1 stem loop interacting with FMRP (SoSLIP), in the 5'-UTR region of superoxide dismutase SOD1 mRNA (By similarity). Binds to the dendritic, small non-coding brain cytoplasmic RNA 1 (BC1); which may increase the association of the CYFIP1-EIF4E-FMR1 complex to FMR1 target mRNAs at synapses (By similarity). Plays a role in mRNA nuclear export. Specifically recognizes and binds a subset of N6-methyladenosine (m6A)-containing mRNAs, promoting their nuclear export in a XPO1/CRM1-dependent manner (By similarity). Together with export factor NXF2, is involved in the regulation of the NXF1 mRNA stability in neurons (By similarity). Associates with export factor NXF1 mRNA-containing ribonucleoprotein particles (mRNPs) in a NXF2-dependent manner (By similarity). Binds to a subset of miRNAs in the brain. May associate with nascent transcripts in a nuclear protein NXF1-dependent manner. In vitro, binds to RNA homomer; preferentially on poly(G) and to a lesser extent on poly(U), but not on poly(A) or poly(C). Moreover, plays a role in the modulation of the sodium-activated potassium channel KCNT1 gating activity (By similarity). Negatively regulates the voltage-dependent calcium channel current density in soma and presynaptic terminals of dorsal root ganglion (DRG) neurons, and hence regulates synaptic vesicle exocytosis (PubMed:24709664). Modulates the voltage-dependent calcium channel CACNA1B expression at the plasma membrane by targeting the channels for proteasomal degradation (By similarity). Plays a role in regulation of MAP1B-dependent microtubule dynamics during neuronal development (By similarity). Has been shown to play a translation-independent role in the modulation of presynaptic action potential (AP) duration and neurotransmitter release via large-conductance calcium-activated potassium (BK) channels in hippocampal and cortical excitatory neurons. May be involved in the control of DNA damage response (DDR) mechanisms through the regulation of ATR-dependent signaling pathways such as histone H2AX/H2A.x and BRCA1 phosphorylations (By similarity). Forms a cytoplasmic messenger ribonucleoprotein (mRNP) network by packaging long mRNAs, serving as a scaffold that recruits proteins and signaling molecules. This network facilitates signaling reactions by maintaining proximity between kinases and substrates (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; Ribosomes in RNA Granules Are Stalled on mRNA Sequences That Are Consensus Sites for FMRP Association., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 19, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P70568", "ec_number_list": [], "go_molecular_function": "GO:1990825 sequence-specific mRNA binding;GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0008017 microtubule binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:2000301 negative regulation of synaptic vesicle exocytosis;GO:0060538 skeletal muscle organ development;GO:0060965 negative regulation of miRNA-mediated gene silencing;GO:0098976 excitatory chemical synaptic transmission;GO:0098817 evoked excitatory postsynaptic potential", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q80WE1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYH9-1", "uniprot_id": [ { "id": "DAAF1_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYH9", "type": "external" } ], "mass": 69956.0, "length": 633, "protein_name": "Dynein axonemal assembly factor 1", "gene_name": "Dnaaf1", "organism": "Rat", "refseq_name": "dynein axonemal assembly factor 1", "refseq_ac": [ { "id": "NP_001014176", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014176", "type": "external" } ], "gene_names_uniprotkb": "Dnaaf1; Lrrc50", "gene_names_refseq": "Dnaaf1; Lrrc50; RGD1310542", "protein_names_uniprotkb": "Dynein axonemal assembly factor 1; Leucine-rich repeat-containing protein 50", "protein_names_refseq": "dynein assembly factor 1, axonemal; dynein axonemal assembly factor 1; leucine rich repeat containing 50; leucine-rich repeat-containing protein 50", "tax_id": 10116, "disease": "idiopathic scoliosis (Disease Ontology:DOID:0060250); primary ciliary dyskinesia 13 (Disease Ontology:DOID:0110618); seminoma (Disease Ontology:DOID:4440); testicular germ cell cancer (Disease Ontology:DOID:5557); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898)", "pathway": " (rno:361419)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Cilium-specific protein required for the stability of the ciliary architecture. Plays a role in cytoplasmic preassembly of dynein arms (By similarity). Involved in regulation of microtubule-based cilia and actin-based brush border microvilli (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0070840 dynein complex binding", "go_cellular_component": "GO:0005930 axoneme;GO:0005929 cilium", "go_biological_process": "GO:0060972 left/right pattern formation;GO:0030324 lung development;GO:0060271 cilium assembly;GO:0007368 determination of left/right symmetry;GO:0001947 heart looping", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AYH9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYX5-1", "uniprot_id": [ { "id": "ODFP2_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYX5", "type": "external" } ], "mass": 95440.0, "length": 825, "protein_name": "Outer dense fiber protein 2", "gene_name": "Odf2", "organism": "Rat", "refseq_name": "outer dense fiber protein 2 isoform 1", "refseq_ac": [ { "id": "NP_001138477", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138477", "type": "external" } ], "gene_names_uniprotkb": "Odf2; KKT4; Odf84", "gene_names_refseq": "Odf2", "protein_names_uniprotkb": "Outer dense fiber protein 2; 84 kDa outer dense fiber protein; Cenexin; Outer dense fiber of sperm tails protein 2", "protein_names_refseq": "84 kDa outer dense fiber protein; cenexin; outer dense fiber of sperm tail 2; outer dense fiber of sperm tails protein 2; outer dense fiber protein 2 isoform 1; outer dense fiber protein 2; sperm outer dense fiber major protein 2; testis-specific autoantigen", "tax_id": 10116, "disease": "Zollinger-Ellison syndrome (Disease Ontology:DOID:0050782); inclusion body myopathy with Paget disease of bone and frontotemporal dementia (Disease Ontology:DOID:0050881); primary hypomagnesemia (Disease Ontology:DOID:0060879); renal hypomagnesemia 4 (Disease Ontology:DOID:0060882); lupus nephritis (Disease Ontology:DOID:0080162); Alzheimer's disease (Disease Ontology:DOID:10652); microcephaly (Disease Ontology:DOID:10907); endometrial cancer (Disease Ontology:DOID:1380); Parkinson's disease (Disease Ontology:DOID:14330); pancreatic cancer (Disease Ontology:DOID:1793); ovarian cancer (Disease Ontology:DOID:2394); acute kidney failure (Disease Ontology:DOID:3021); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); gallbladder cancer (Disease Ontology:DOID:3121); oligodendroglioma (Disease Ontology:DOID:3181); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); pancreatitis (Disease Ontology:DOID:4989); schizophrenia (Disease Ontology:DOID:5419); hepatocellular carcinoma (Disease Ontology:DOID:684); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677)", "pathway": " (rno:29479); (R-RNO-2565942); (R-RNO-380259); (R-RNO-380270); (R-RNO-380284); (R-RNO-380320); (R-RNO-5620912); (R-RNO-8854518)", "pathway_count": 8, "publication_count": 7, "publication_id_list": "15340007;15344312;22673903;9045620;9092585;9369191;9698445", "class_list": "", "function": "Data demonstrate that outer dense fibre protein 2 is a self-interacting protein that forms a fibrillar structure partially linked to the microtubule network., [RefSeq, PubMed]; Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the localization of PLK1 and NIN to the centrosomes. Required for the formation and/or maintenance of normal CETN1 assembly., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The results suggested that the expression pattern of cenexin in rat spermatogenesis might be related to the initiation of the flagella formation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 23, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O70408;P97575;Q62693;Q9JIZ3", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding", "go_cellular_component": "GO:0001520 outer dense fiber;GO:0000922 spindle pole;GO:0005813 centrosome;GO:0005874 microtubule;GO:0005929 cilium", "go_biological_process": "GO:0007286 spermatid development;GO:0008104 intracellular protein localization;GO:1902017 regulation of cilium assembly;GO:0010457 centriole-centriole cohesion;GO:0044782 cilium organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6AYX5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B5DEH0-1", "uniprot_id": [ { "id": "LIMD1_RAT", "url": "https://www.uniprot.org/uniprot/B5DEH0", "type": "external" } ], "mass": 71393.0, "length": 663, "protein_name": "LIM domain-containing protein 1", "gene_name": "Limd1", "organism": "Rat", "refseq_name": "LIM domain-containing protein 1", "refseq_ac": [ { "id": "NP_001106208", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106208", "type": "external" } ], "gene_names_uniprotkb": "Limd1", "gene_names_refseq": "Limd1", "protein_names_uniprotkb": "LIM domain-containing protein 1", "protein_names_refseq": "LIM domain-containing protein 1; LIM domains containing 1", "tax_id": 10116, "disease": "", "pathway": " (rno:316101); (R-RNO-1234176)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22673903;33847835", "class_list": "", "function": "Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation (By similarity)., [UniProtKB]; SKI activates the Hippo pathway via LIMD1 to inhibit cardiac fibroblast activation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005912 adherens junction;GO:0005925 focal adhesion", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0001666 response to hypoxia;GO:0006355 regulation of DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B5DEH0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20816-1", "uniprot_id": [ { "id": "CP4A2_RAT", "url": "https://www.uniprot.org/uniprot/P20816", "type": "external" } ], "mass": 57969.0, "length": 504, "protein_name": "Cytochrome P450 4A2", "gene_name": "Cyp4a2l1; Cyp4a2; Cyp4a3", "organism": "Rat", "refseq_name": "cytochrome P450 4A2", "refseq_ac": [ { "id": "NP_001038235", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038235", "type": "external" } ], "gene_names_uniprotkb": "Cyp4a2l1; Cyp4a2; Cyp4a3; Cyp4a-2; Cyp4a11; Cyp4a2l1; Cyp4a2; Cyp4a3; Cyp4b1; LOC120102953", "gene_names_refseq": "Cyp4a11; Cyp4a2", "protein_names_uniprotkb": "Cytochrome P450 4A2; 1.14.14.80; CYPIVA2; Cytochrome P-450 K-2; Cytochrome P450 K-5; Cytochrome P450-LA-omega 2; Lauric acid omega-hydroxylase; Long-chain fatty acid omega-monooxygenase", "protein_names_refseq": "CYPIVA2; P-450 IV4AII; P-450 K-2; P450 K-5; P450-LA-omega 2; cytochrome P-450 K-2; cytochrome P450 4A2-like; cytochrome P450 4A2; cytochrome P450 K-5; cytochrome P450, subfamily 4A, polypeptide 11; cytochrome P450, subfamily IVA, polypeptide 11; cytochrome P450-LA-omega 2; lauric acid omega-hydroxylase; long-chain fatty acid omega-monooxygenase", "tax_id": 10116, "disease": "autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); hypertension (Disease Ontology:DOID:10763)", "pathway": " (rno:24306); (R-RNO-211935); (R-RNO-211958); (R-RNO-211979); (R-RNO-2142691)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "10620324;10869363;11139583;16543501;1739747;19675180;22673903;2306108;27174801;27194719;2766932", "class_list": "", "function": "A cytochrome P450 monooxygenase that catalyzes omega and omega-1 hydroxylation of saturated fatty acids. Exhibits preferential omega versus omega-1 regioselectivity and (R) versus (S) stereoselectivity for hydroxylation of lauric and myristic acids (PubMed:10620324, PubMed:10869363). Has low activity toward palmitic acid (PubMed:10620324). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:10620324, PubMed:10869363)., [UniProtKB, PubMed, PubMed]; Augmentation of vascular endothelial 20-HETE levels by CYP4A2 overexpression results in hypertension, endothelial dysfunction, and renal injury., [RefSeq, PubMed]; Dihydrotestosterone decreased omega-hydroxylase activity in ) female rats (by 50%) but significantly increased omega-hydroxylase activity in CYP4A2(-/-) female rats, [RefSeq, PubMed]; Here we report that cultured astrocytes express CYP 4A2/3 omega-hydroxylase mRNA and CYP 4A protein and produce 20-HETE and the CYP epoxygenase metabolites epoxyeicosatrienoic acids (EETs) when incubated with AA, [RefSeq, PubMed]; Intravenous injection of adenovirus transfected-CYP4A2 increased blood pressure and hypertension., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q4G071", "ec_number_list": [ { "id": "1.14.14.80", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.80", "type": "external" }, { "id": "1.14.14.79", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.79", "type": "external" }, { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" }, { "id": "1.14.14.94", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.94", "type": "external" } ], "go_molecular_function": "GO:0008405 arachidonate 11,12-epoxygenase activity;GO:0005504 fatty acid binding;GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0050544 arachidonate binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0046456 icosanoid biosynthetic process;GO:0001822 kidney development;GO:0043651 linoleic acid metabolic process;GO:0009725 response to hormone;GO:0009410 response to xenobiotic stimulus", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P20816-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88797-1", "uniprot_id": [ { "id": "DAB2_RAT", "url": "https://www.uniprot.org/uniprot/O88797", "type": "external" } ], "mass": 82377.0, "length": 768, "protein_name": "Disabled homolog 2", "gene_name": "Dab2", "organism": "Rat", "refseq_name": "disabled homolog 2 isoform 1", "refseq_ac": [ { "id": "NP_077073", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077073", "type": "external" } ], "gene_names_uniprotkb": "Dab2; Doc2", "gene_names_refseq": "Dab2; Doc-2; Doc2", "protein_names_uniprotkb": "Disabled homolog 2; Adaptor molecule disabled-2; C9; DOC-2; Differentially expressed in ovarian carcinoma 2; Mitogen-responsive phosphoprotein", "protein_names_refseq": "C9; DAB2, clathrin adaptor protein; adaptor molecule disabled-2; differentially expressed in ovarian carcinoma 2; disabled 2, mitogen-responsive phosphoprotein; disabled homolog 2 isoform 1; disabled homolog 2 mitogen-responsive phosphoprotein; mitogen-responsive phosphoprotein", "tax_id": 10116, "disease": "metabolic acidosis (Disease Ontology:DOID:0050758); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (rno:79128); (R-RNO-190873); (R-RNO-196025); (R-RNO-8856825); (R-RNO-8856828)", "pathway_count": 5, "publication_count": 13, "publication_id_list": "11812785;12473651;19000037;19665975;21097498;22673903;24122887;25432322;29393594;30052485;31868265;34502162;9681506", "class_list": "", "function": "Adapter protein that functions as a clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor., [UniProtKB, PubMed, PubMed]; Phosphorylation of Dab2 is involved in inhibited VEGF-VEGFR-2 signaling induced by downregulation of syndecan-1 in glomerular endothelial cell., [RefSeq, PubMed]; Showed that Dab2 expression in cultured tubular epithelial cells is involved in endocytic regulation and that it also protects cells from TGF-beta-induced epithelial-to-mesenchymal transition, [RefSeq, PubMed]; These findings suggest that both isoforms of Dab-2 are transiently upregulated in response to SCI and that the increased expression of Dab-2 is associated with the early activation of macrophages and astrogliosis, [RefSeq, PubMed]; We conclude that the megalin/cubilin/amnionless/Dab2 complex/es participate in intestinal processes, mainly during the lactation period and that Dab2 may act as an adaptor in intestinal processes mediated by ApoER2 and VLDLR., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O55048;O55049;O55050;O55051;O88798;Q4QRA2", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0050750 low-density lipoprotein particle receptor binding;GO:0035612 AP-2 adaptor complex binding;GO:0046332 SMAD binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0097017 renal protein absorption;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0015031 protein transport;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "O88797-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LQ70-1", "uniprot_id": [ { "id": "LOX12_RAT", "url": "https://www.uniprot.org/uniprot/F1LQ70", "type": "external" } ], "mass": 75534.0, "length": 663, "protein_name": "Polyunsaturated fatty acid lipoxygenase ALOX12", "gene_name": "Alox12", "organism": "Rat", "refseq_name": "polyunsaturated fatty acid lipoxygenase ALOX12", "refseq_ac": [ { "id": "NP_001099268", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099268", "type": "external" } ], "gene_names_uniprotkb": "Alox12", "gene_names_refseq": "12-LO; 12S-LOX; Alox12", "protein_names_uniprotkb": "Polyunsaturated fatty acid lipoxygenase ALOX12; 1.13.11.-; 1.13.11.31; 1.13.11.33; 12S-LOX; 12S-lipoxygenase; Arachidonate (12S)-lipoxygenase; Arachidonate (15S)-lipoxygenase; Linoleate (13S)-lipoxygenase; Lipoxin synthase 12-LO; Platelet-type lipoxygenase 12", "protein_names_refseq": "12S-lipoxygenase; arachidonate (12S)-lipoxygenase; arachidonate (15S)-lipoxygenase; arachidonate 15-lipoxygenase,15S-type; linoleate 13S-lipoxygenase; lipoxin synthase 12-LO; platelet 12-LOX; platelet-type lipoxygenase 12; polyunsaturated fatty acid lipoxygenase ALOX12", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); breast cancer (Disease Ontology:DOID:1612); renal cell carcinoma (Disease Ontology:DOID:4450); congestive heart failure (Disease Ontology:DOID:6000); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); psoriasis (Disease Ontology:DOID:8893); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:287454); (R-RNO-2142696); (R-RNO-2142700); (R-RNO-2142712); (R-RNO-9018677); (R-RNO-9025106); (R-RNO-9026290)", "pathway_count": 7, "publication_count": 6, "publication_id_list": "15105833;22673903;23382512;24816396;27021232;27600103", "class_list": "", "function": "Angiotensin II type 1 receptor blocker potentially ameliorates diabetic nephropathy via the up-regulation of glomerular nephrin and P-cadherin expression through the inhibition of 12-LO activation in the glomeruli of rats with type 2 diabetes., [RefSeq, PubMed]; Catalyzes the regio and stereo-specific incorporation of molecular oxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding hydroxy species (PubMed:23382512). Mainly converts arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) to the specific bioactive lipid (12S)-hydroperoxyeicosatetraenoate/(12S)-HPETE. Through the production of bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation. It can also catalyze the epoxidation of double bonds of polyunsaturated fatty acids such as (14S)-hydroperoxy-docosahexaenoate/(14S)-HPDHA resulting in the formation of (13S,14S)-epoxy-DHA. Furthermore, it may participate in the sequential oxidations of DHA ((4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate) to generate specialized pro-resolving mediators (SPMs) like resolvin D5 ((7S,17S)-diHPDHA) and (7S,14S)-diHPDHA, that actively down-regulate the immune response and have anti-aggregation properties with platelets (By similarity). An additional function involves a multistep process by which it transforms leukotriene A4/LTA4 into the bioactive lipids lipoxin A4/LXA4 and lipoxin B4/LXB4, both are vasoactive and LXA4 may regulate neutrophil function via occupancy of specific recognition sites (PubMed:23382512). Can also peroxidize linoleate ((9Z,12Z)-octadecadienoate) to (13S)-hydroperoxyoctadecadienoate/ (13S-HPODE) (By similarity). Due to its role in regulating both the expression of the vascular endothelial growth factor (VEGF, an angiogenic factor involved in the survival and metastasis of solid tumors) and the expression of integrin beta-1 (known to affect tumor cell migration and proliferation), it can be regarded as protumorigenic. Important for cell survival, as it may play a role not only in proliferation but also in the prevention of apoptosis in vascular smooth muscle cells (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Hypoxic preconditioning reduces heart susceptibly to ischemia-reperfusion injuryvia ALOX12/TRPV1/PKC pathway., [RefSeq, PubMed]; The aim of the present study was to examine the impacts and mechanisms of 12lipoxygenase (12LO) and its metabolites on the acetylation and methylation of histone3lysine (H3K) in the p21 gene. associated epigenetic changes, including increased histone H3K9Ac and H3K4Me1, and reduced H3K9M.e3 may involved in 12 (S)hydroxyeicosatetraenoic acid mediated p21 gene regulation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.31", "type": "external" }, { "id": "1.13.11.33", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.33", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "1.13.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.12", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0016787 hydrolase activity;GO:0004052 arachidonate 12(S)-lipoxygenase activity;GO:0016165 linoleate 13S-lipoxygenase activity;GO:0050473 arachidonate 15-lipoxygenase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0042383 sarcolemma", "go_biological_process": "GO:0034440 lipid oxidation;GO:0006629 lipid metabolic process;GO:0043066 negative regulation of apoptotic process;GO:0061436 establishment of skin barrier;GO:0043651 linoleic acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "F1LQ70-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R511-1", "uniprot_id": [ { "id": "FNBP1_RAT", "url": "https://www.uniprot.org/uniprot/Q8R511", "type": "external" } ], "mass": 71293.0, "length": 616, "protein_name": "Formin-binding protein 1", "gene_name": "Fnbp1", "organism": "Rat", "refseq_name": "formin-binding protein 1 isoform 1", "refseq_ac": [ { "id": "NP_620269", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620269", "type": "external" } ], "gene_names_uniprotkb": "Fnbp1; Fbp17", "gene_names_refseq": "Fnbp1", "protein_names_uniprotkb": "Formin-binding protein 1; Formin-binding protein 17; Rapostlin", "protein_names_refseq": "formin-binding protein 1 isoform 1; formin-binding protein 1-like; formin-binding protein 17; rapostlin", "tax_id": 10116, "disease": "", "pathway": " (rno:192348); (R-RNO-8856828); (R-RNO-9013406); (R-RNO-9696270)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "12244061;14502124;14732713;16303198;16357825;21768103;22673903", "class_list": "", "function": "Data show that rapostlin is the first effector of Rnd2, regulating neurite branch formation., [RefSeq, PubMed]; F-BAR protein Rapostlin, whose activity is regulated by Rnd2, plays a key role in spine formation through the regulation of membrane dynamics., [RefSeq, PubMed]; Functionally different splicing variants of Rapostlin have different responses to Rnd2 in association with N-WASP., [RefSeq, PubMed]; Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL (By similarity). May act as a link between RND2 signaling and regulation of the actin cytoskeleton. Isoform 1 and isoform 2 promote RND2-induced neurite branching in neuronal cells., [UniProtKB, PubMed, PubMed]; Rnd2 functions in vivo as a regulator of the migration and morphological changes associated with the development of pyramidal neurons, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q75UE2;Q75UE3;Q75UE4;Q75UE5;Q75UE6", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0005938 cell cortex;GO:0005764 lysosome", "go_biological_process": "GO:0006897 endocytosis;GO:0007165 signal transduction;GO:0007399 nervous system development;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8R511-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54370-1", "uniprot_id": [ { "id": "OAZ1_RAT", "url": "https://www.uniprot.org/uniprot/P54370", "type": "external" } ], "mass": 25228.0, "length": 227, "protein_name": "Ornithine decarboxylase antizyme 1", "gene_name": "Oaz1", "organism": "Rat", "refseq_name": "ornithine decarboxylase antizyme 1 isoform 1", "refseq_ac": [ { "id": "NP_620781", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620781", "type": "external" } ], "gene_names_uniprotkb": "Oaz1; Oaz", "gene_names_refseq": "ODC-Az; ODCAC; Oaz1; Oaz", "protein_names_uniprotkb": "Ornithine decarboxylase antizyme 1; ODC-Az", "protein_names_refseq": "ornithine decarboxylase antizyme 1 isoform 1", "tax_id": 10116, "disease": "arterial tortuosity syndrome (Disease Ontology:DOID:0050645); autosomal recessive cutis laxa type IB (Disease Ontology:DOID:0070133); aortic dissection (Disease Ontology:DOID:0080685); endometrial cancer (Disease Ontology:DOID:1380); brain ischemia (Disease Ontology:DOID:2316); ovarian cancer (Disease Ontology:DOID:2394); cervix carcinoma (Disease Ontology:DOID:2893); cutis laxa (Disease Ontology:DOID:3144); osteosarcoma (Disease Ontology:DOID:3347); bone osteosarcoma (Disease Ontology:DOID:3376); aortic aneurysm (Disease Ontology:DOID:3627); coronary restenosis (Disease Ontology:DOID:4247); osteoarthritis (Disease Ontology:DOID:8398)", "pathway": " (rno:25502); (R-RNO-350562); (R-RNO-351202)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "16128579;21861313;7813017;8166639", "class_list": "", "function": "Antizyme expression requires programmed,+1 ribosomal frameshifting, [RefSeq, PubMed]; Corticosterone treatment induces antizyme 1 protein synthesis in early regenerating rat liver. However, it has little effect on antizyme 1 gene transcription., [RefSeq, PubMed]; Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome. Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC. Stabilizes AZIN2 by interfering with its ubiquitination (By similarity). Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter (PubMed:8166639). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs; and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization. Alternatively spliced transcript variants have also been noted for this gene. [provided by RefSeq, Dec 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0044877 protein-containing complex binding;GO:0008073 ornithine decarboxylase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0072750 cellular response to leptomycin B;GO:1902268 negative regulation of polyamine transmembrane transport;GO:0002931 response to ischemia;GO:0090316 positive regulation of intracellular protein transport;GO:0045732 positive regulation of protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P54370-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10686-1", "uniprot_id": [ { "id": "PLCG1_RAT", "url": "https://www.uniprot.org/uniprot/P10686", "type": "external" } ], "mass": 148548.0, "length": 1290, "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1", "gene_name": "Plcg1", "organism": "Rat", "refseq_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1", "refseq_ac": [ { "id": "NP_037319", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037319", "type": "external" } ], "gene_names_uniprotkb": "Plcg1", "gene_names_refseq": "PPLCA; Plcg1", "protein_names_uniprotkb": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; 3.1.4.11; PLC-gamma-1; Phosphoinositide phospholipase C-gamma-1; Phospholipase C-gamma-1", "protein_names_refseq": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; PLC-148; PLC-II; PLC-gamma-1; phosphoinositide phospholipase C-gamma-1; phosphoinositide phospholipase C", "tax_id": 10116, "disease": "familial adenomatous polyposis (Disease Ontology:DOID:0050424); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); Alzheimer's disease (Disease Ontology:DOID:10652); breast cancer (Disease Ontology:DOID:1612); colon cancer (Disease Ontology:DOID:219); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); breast carcinoma (Disease Ontology:DOID:3459); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256); acute myocardial infarction (Disease Ontology:DOID:9408)", "pathway": " (rno:25738); (R-RNO-1169408); (R-RNO-1855204); (R-RNO-186763); (R-RNO-201556); (R-RNO-202433); (R-RNO-2029485); (R-RNO-210990); (R-RNO-212718); (R-RNO-2424491); (R-RNO-2871796); (R-RNO-2871809); (R-RNO-5218921); (R-RNO-5654219); (R-RNO-5654221); (R-RNO-5654227); (R-RNO-5654228); (R-RNO-8853659); (R-RNO-9026527); (R-RNO-9034793)", "pathway_count": 20, "publication_count": 17, "publication_id_list": "11823862;15252117;15764700;16500902;19605547;22330086;22673903;2840660;28794269;29435116;31889510;35848503;39159149;7518429;7531435;8392838;9281317", "class_list": "", "function": "Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (PubMed:7531435). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:7531435). Plays a role in actin reorganization and cell migration (By similarity). Guanine nucleotide exchange factor that binds the GTPase DNM1 and catalyzes the dissociation of GDP, allowing a GTP molecule to bind in its place, therefore enhancing DNM1-dependent endocytosis (PubMed:15252117)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Methylation-mediated silencing of PTPRD induces pulmonary hypertension by promoting pulmonary arterial smooth muscle cell migration via the PDGFRB/PLCgamma1 axis., [RefSeq, PubMed]; PLCgamma1 deficiency in chondrocytes accelerates the age-related changes in articular cartilage and subchondral bone., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "6.3.2.n3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.n3", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" } ], "go_molecular_function": "GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0005158 insulin receptor binding;GO:0019901 protein kinase binding;GO:0004629 phospholipase C activity;GO:0051219 phosphoprotein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0032959 inositol trisphosphate biosynthetic process;GO:1905564 positive regulation of vascular endothelial cell proliferation;GO:1904643 response to curcumin;GO:0031161 phosphatidylinositol catabolic process;GO:0001701 in utero embryonic development", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P10686-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15304-1", "uniprot_id": [ { "id": "LIPS_RAT", "url": "https://www.uniprot.org/uniprot/P15304", "type": "external" } ], "mass": 116812.0, "length": 1068, "protein_name": "Hormone-sensitive lipase", "gene_name": "Lipe", "organism": "Rat", "refseq_name": "hormone-sensitive lipase", "refseq_ac": [ { "id": "NP_036991", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036991", "type": "external" } ], "gene_names_uniprotkb": "Lipe", "gene_names_refseq": "HSL; Lipe; REH", "protein_names_uniprotkb": "Hormone-sensitive lipase; 3.1.1.23; 3.1.1.79; HSL; Monoacylglycerol lipase LIPE; REH; Retinyl ester hydrolase", "protein_names_refseq": "hormone-sensitive lipase; lipase, hormone sensitive; monoacylglycerol lipase LIPE; retinyl ester hydrolase", "tax_id": 10116, "disease": "autosomal dominant intellectual developmental disorder 33 (Disease Ontology:DOID:0070063); familial partial lipodystrophy type 6 (Disease Ontology:DOID:0070206); hypertension (Disease Ontology:DOID:10763); heart disease (Disease Ontology:DOID:114); spinal muscular atrophy (Disease Ontology:DOID:12377); arteriosclerosis (Disease Ontology:DOID:2349); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25330)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10694408;15878856;1770312;18180326;20621463;22673903;22951290;24303154;25448749;26141235;26506094;31150775;3186461;32967199;3420405;6374655;6643478;8812477;9162045;9417067", "class_list": "", "function": "HSL regulates vitamin A metabolism in quiescent hepatic stellate cells., [RefSeq, PubMed]; Habitual exercise training acts as a physiological stimulator for constant activation of lipolytic enzymes, HSL and ATGL, in rat primary white adipocytes., [RefSeq, PubMed]; Lipase with broad substrate specificity, catalyzing the hydrolysis of triacylglycerols (TAGs), diacylglycerols (DAGs), monoacylglycerols (MAGs), cholesteryl esters and retinyl esters (PubMed:10694408, PubMed:6643478, PubMed:9162045). Shows a preferential hydrolysis of DAGs over TAGs and MAGs and preferentially hydrolyzes the fatty acid (FA) esters at the sn-3 position of DAGs (By similarity). Preferentially hydrolyzes fatty acids at the sn-1 and sn-2 positions of TAGs (PubMed:6643478). Catalyzes the hydrolysis of 2-arachidonoylglycerol, an endocannabinoid and of 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor (By similarity). In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production (PubMed:1770312)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; The findings suggest that progesterone, acting in a progesterone receptor-dependent manner, down-regulates Lipe gene expression but exerts no effect on Pnpla2 gene expression in the inguinal white adipose tissue of females., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6LCQ2", "ec_number_list": [ { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.71", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.71", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "3.1.1.88", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.88", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.28", "type": "external" }, { "id": "3.3.2.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.9", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.116", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.116", "type": "external" }, { "id": "3.1.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.1", "type": "external" }, { "id": "3.1.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.67", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.26", "type": "external" }, { "id": "3.5.1.99", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.99", "type": "external" }, { "id": "3.1.1.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.34", "type": "external" }, { "id": "3.1.1.111", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.111", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.3.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.20", "type": "external" }, { "id": "2.3.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.76", "type": "external" } ], "go_molecular_function": "GO:0004771 sterol ester esterase activity;GO:0016298 lipase activity;GO:0016788 hydrolase activity, acting on ester bonds;GO:0019901 protein kinase binding;GO:0047372 monoacylglycerol lipase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005811 lipid droplet", "go_biological_process": "GO:0070417 cellular response to cold;GO:0008203 cholesterol metabolic process;GO:0016042 lipid catabolic process;GO:0042758 long-chain fatty acid catabolic process;GO:0007565 female pregnancy", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P15304-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63787-1", "uniprot_id": [ { "id": "P85A_RAT", "url": "https://www.uniprot.org/uniprot/Q63787", "type": "external" } ], "mass": 83531.0, "length": 724, "protein_name": "Phosphatidylinositol 3-kinase regulatory subunit alpha", "gene_name": "Pik3r1", "organism": "Rat", "refseq_name": "phosphatidylinositol 3-kinase regulatory subunit alpha", "refseq_ac": [ { "id": "NP_037137", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037137", "type": "external" } ], "gene_names_uniprotkb": "Pik3r1", "gene_names_refseq": "PI3KA; Pik3r1", "protein_names_uniprotkb": "Phosphatidylinositol 3-kinase regulatory subunit alpha; PI3-kinase regulatory subunit alpha; PI3-kinase subunit p85-alpha; PI3K regulatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; PtdIns-3-kinase regulatory subunit p85-alpha", "protein_names_refseq": "PI3-kinase p85 subunit alpha; PI3-kinase regulatory subunit alpha; PI3-kinase subunit p85-alpha; PI3K regulatory subunit alpha; Phosphoinositide 3-kinase p85 (other splicing variants: p55 and p50); Phosphoinositide 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha); phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; phosphatidylinositol 3-kinase p85 alpha; phosphatidylinositol 3-kinase regulatory subunit alpha; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha); phosphoinositide-3-kinase, regulatory subunit 1 (alpha); ptdIns-3-kinase p85-alpha; ptdIns-3-kinase regulatory subunit alpha; ptdIns-3-kinase regulatory subunit p85-alpha", "tax_id": 10116, "disease": "agammaglobulinemia 7 (Disease Ontology:DOID:0081139); SHORT syndrome (Disease Ontology:DOID:0111454); immunodeficiency 36 (Disease Ontology:DOID:0111949); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); endometrial cancer (Disease Ontology:DOID:1380); X-linked agammaglobulinemia (Disease Ontology:DOID:14179); endometrial adenocarcinoma (Disease Ontology:DOID:2870); endometrial carcinoma (Disease Ontology:DOID:2871); lung adenocarcinoma (Disease Ontology:DOID:3910); renal cell carcinoma (Disease Ontology:DOID:4450); lung small cell carcinoma (Disease Ontology:DOID:5409); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); astroblastoma (Disease Ontology:DOID:7305); osteoarthritis (Disease Ontology:DOID:8398); colorectal cancer (Disease Ontology:DOID:9256); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25513); (R-RNO-109704); (R-RNO-112399); (R-RNO-114604); (R-RNO-1250342); (R-RNO-1257604); (R-RNO-1266695); (R-RNO-1433557); (R-RNO-1660499); (R-RNO-180292); (R-RNO-186763); (R-RNO-1963642); (R-RNO-198203); (R-RNO-201556); (R-RNO-202424); (R-RNO-2029485); (R-RNO-210993); (R-RNO-2424491); (R-RNO-2730905); (R-RNO-389357); (R-RNO-416476); (R-RNO-430116); (R-RNO-4420097); (R-RNO-512988); (R-RNO-5654689); (R-RNO-5654695); (R-RNO-5654710); (R-RNO-5654720); (R-RNO-5673001); (R-RNO-6811558); (R-RNO-8851907); (R-RNO-8853659); (R-RNO-8980692); (R-RNO-9009391); (R-RNO-9013026); (R-RNO-9013106); (R-RNO-9013148); (R-RNO-9013149); (R-RNO-9013404); (R-RNO-9013408); (R-RNO-9013409); (R-RNO-9013420); (R-RNO-9013423); (R-RNO-9013424); (R-RNO-9027276); (R-RNO-9035034); (R-RNO-912526); (R-RNO-912631); (R-RNO-9607240); (R-RNO-9696264); (R-RNO-9696270); (R-RNO-9696273); (R-RNO-983695); (R-RNO-9842663); (R-RNO-9927354)", "pathway_count": 55, "publication_count": 9, "publication_id_list": "11353842;14985449;33215443;7518429;8621382;8628286;8824286;8921377;9065454", "class_list": "", "function": "Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; MiRNA-1 promotes pyroptosis of cardiomyocytes and release of inflammatory factors by downregulating the expression level of PIK3R1 through the FoxO3a pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 21, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O55085;P70544;Q63790", "ec_number_list": [], "go_molecular_function": "GO:0019209 kinase activator activity;GO:0005161 platelet-derived growth factor receptor binding;GO:0001784 phosphotyrosine residue binding;GO:0005096 GTPase activator activity;GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005911 cell-cell junction;GO:0016020 membrane", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0033120 positive regulation of RNA splicing;GO:0001878 response to yeast;GO:0001934 positive regulation of protein phosphorylation;GO:0006468 protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q63787-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35052-1", "uniprot_id": [ { "id": "CDS1_RAT", "url": "https://www.uniprot.org/uniprot/O35052", "type": "external" } ], "mass": 52970.0, "length": 461, "protein_name": "Phosphatidate cytidylyltransferase 1", "gene_name": "Cds1", "organism": "Rat", "refseq_name": "phosphatidate cytidylyltransferase 1", "refseq_ac": [ { "id": "NP_112521", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112521", "type": "external" } ], "gene_names_uniprotkb": "Cds1; Cds", "gene_names_refseq": "Cds1", "protein_names_uniprotkb": "Phosphatidate cytidylyltransferase 1; 2.7.7.41; CDP-DAG synthase 1; CDP-DG synthase 1; CDP-diacylglycerol synthase 1; CDP-diglyceride pyrophosphorylase 1; CDP-diglyceride synthase 1; CDS 1; CTP:phosphatidate cytidylyltransferase 1", "protein_names_refseq": "CDP-DAG synthase 1; CDP-DG synthase 1; CDP-DG synthetase 1; CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1; CDP-diglyceride pyrophosphorylase 1; CDP-diglyceride synthase 1; CDP-diglyceride synthetase 1; CDS 1; CTP:phosphatidate cytidylyltransferase 1; phosphatidate cytidylyltransferase 1", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (rno:81925); (R-RNO-1483226)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "22673903;29253589;30862571;6271231;9083091;9345289", "class_list": "", "function": "CDS activity present in mitochondria is mainly due to TAMM41, which is required for normal mitochondrial function., [RefSeq, PubMed]; Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol (PubMed:29253589, PubMed:30862571, PubMed:9083091, PubMed:9345289). Exhibits almost no acyl chain preference for PA, showing no discrimination for the sn-1/sn-2 acyl chain composition of PAs (By similarity). Plays an important role in regulatinng the growth of lipid droplets which are storage organelles at the center of lipid and energy homeostasis (By similarity). Positively regulates the differentiation and development of adipocytes (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, UniProtKB, PubMed, UniProtKB, UniProtKB]; Vasopressin stimulates CDS1 mRNA through phospholipase C, protein kinase C and cFos and provides a potential mechanism for maintenance of phosphatidylinositol levels during long-term phospholipase C signalling., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0JPL6;O88208", "ec_number_list": [ { "id": "2.7.7.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.41", "type": "external" } ], "go_molecular_function": "GO:0004605 phosphatidate cytidylyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0045600 positive regulation of fat cell differentiation;GO:0006661 phosphatidylinositol biosynthetic process;GO:0140042 lipid droplet formation;GO:0016024 CDP-diacylglycerol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O35052-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88278-1", "uniprot_id": [ { "id": "CELR3_RAT", "url": "https://www.uniprot.org/uniprot/O88278", "type": "external" } ], "mass": 359355.0, "length": 3313, "protein_name": "Cadherin EGF LAG seven-pass G-type receptor 3", "gene_name": "Celsr3", "organism": "Rat", "refseq_name": "cadherin EGF LAG seven-pass G-type receptor 3 precursor", "refseq_ac": [ { "id": "NP_112610", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112610", "type": "external" } ], "gene_names_uniprotkb": "Celsr3; Megf2", "gene_names_refseq": "Celsr3; Megf2", "protein_names_uniprotkb": "Cadherin EGF LAG seven-pass G-type receptor 3; Multiple EGF-like domains protein 2; Multiple epidermal growth factor-like domains protein 2", "protein_names_refseq": "cadherin EGF LAG seven-pass G-type receptor 3 precursor; cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila); multiple EGF-like domains protein 2; multiple epidermal growth factor-like domains 2; multiple epidermal growth factor-like domains protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:83466)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16641100;17618280;38843836;9693030", "class_list": "", "function": "Receptor that may have an important role in cell/cell signaling during nervous system formation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The Celsr3 suppressed neurite growth of neuron in hippocampus of rat., [RefSeq, PubMed]", "predicted_glycosites": 19, "predicted_n_glycosites": 15, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 19, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0007409 axonogenesis;GO:0001764 neuron migration;GO:0032880 regulation of protein localization;GO:0060271 cilium assembly;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O88278-1", "record_type": "protein", "filter_code": "0000000.0000101.001000.000000000000001000.0100000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08033-1", "uniprot_id": [ { "id": "CXB1_RAT", "url": "https://www.uniprot.org/uniprot/P08033", "type": "external" } ], "mass": 32004.0, "length": 283, "protein_name": "Gap junction beta-1 protein", "gene_name": "Gjb1", "organism": "Rat", "refseq_name": "gap junction beta-1 protein", "refseq_ac": [ { "id": "NP_058947", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058947", "type": "external" } ], "gene_names_uniprotkb": "Gjb1; Cxn-32", "gene_names_refseq": "Cx32; Cxng; Gjb1", "protein_names_uniprotkb": "Gap junction beta-1 protein; Connexin-32; Cx32; GAP junction 28 kDa liver protein", "protein_names_refseq": "GAP junction 28 kDa liver protein; connexin g; connexin-32; gap junction beta-1 protein; gap junction membrane channel protein beta 1", "tax_id": 10116, "disease": "Charcot-Marie-Tooth disease X-linked dominant 1 (Disease Ontology:DOID:0110209); extrahepatic cholestasis (Disease Ontology:DOID:13619); autoimmune thyroiditis (Disease Ontology:DOID:7188)", "pathway": " (rno:29584); (R-RNO-190704)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "16396499;1667015;21454685;2170122;22673903;2852976;29790387;2987225;3013898;3017758;30268116;3034905;33171391;34678594;38347637", "class_list": "", "function": "Connexin32 gap junction channels deliver miR155-3p to mediate pyroptosis in renal ischemia-reperfusion injury. Publication Status: Online-Only, [RefSeq, PubMed]; Crosstalk Between Connexin32 and Mitochondrial Apoptotic Signaling Pathway Plays a Pivotal Role in Renal Ischemia Reperfusion-Induced Acute Kidney Injury., [RefSeq, PubMed]; GJB1 mutations c.212T>G and c.311A>C induce apoptosis and inwardly rectifying potassium current changes in X-linked Charcot-Marie-Tooth type 1., [RefSeq, PubMed]; Heart and liver connexin expression related to the first stage of aging: A study on naturally aged animals., [RefSeq, PubMed]; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell., [UniProtKB]; These results highlight the role of post translational modifications and lysines in the C-terminal tail of Cx32 in the fine-tuning of Cx32 protein stability and channel-independent functions. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016328 lateral plasma membrane;GO:0005921 gap junction;GO:0032991 protein-containing complex", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0015868 purine ribonucleotide transport;GO:1905867 epididymis development", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P08033-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18265-1", "uniprot_id": [ { "id": "GSK3A_RAT", "url": "https://www.uniprot.org/uniprot/P18265", "type": "external" } ], "mass": 51027.0, "length": 483, "protein_name": "Glycogen synthase kinase-3 alpha", "gene_name": "Gsk3a", "organism": "Rat", "refseq_name": "glycogen synthase kinase-3 alpha", "refseq_ac": [ { "id": "NP_059040", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059040", "type": "external" } ], "gene_names_uniprotkb": "Gsk3a", "gene_names_refseq": "Gsk3a", "protein_names_uniprotkb": "Glycogen synthase kinase-3 alpha; 2.7.11.1; 2.7.11.26; FA; Factor A; GSK-3 alpha; Serine/threonine-protein kinase GSK3A", "protein_names_refseq": "FA; GSK-3 alpha; factor A; glycogen synthase kinase-3 alpha; serine/threonine-protein kinase GSK3A", "tax_id": 10116, "disease": "Parkinsonism (Disease Ontology:DOID:0080855); Alzheimer's disease (Disease Ontology:DOID:10652); amyotrophic lateral sclerosis (Disease Ontology:DOID:332)", "pathway": " (rno:50686)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10455163;11978789;17242403;2164470;22673903;25935310;28440874;29161257;8382613", "class_list": "", "function": "CHP3 functions as a novel negative regulator of cardiomyocyte hypertrophy via inhibition of GSK3alpha/beta phosphorylation., [RefSeq, PubMed]; Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis (By similarity). Regulates glycogen metabolism in liver, but not in muscle (By similarity). May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease (By similarity). May be involved in the regulation of replication in pancreatic beta-cells (PubMed:17242403). Is necessary for the establishment of neuronal polarity and axon outgrowth. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation (By similarity). Acts as a regulator of autophagy by mediating phosphorylation of KAT5/TIP60 under starvation conditions, activating KAT5/TIP60 acetyltransferase activity and promoting acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (By similarity). Negatively regulates extrinsic apoptotic signaling pathway via death domain receptors. Promotes the formation of an anti-apoptotic complex, made of DDX3X, BRIC2 and GSK3B, at death receptors, including TNFRSF10B. The anti-apoptotic function is most effective with weak apoptotic signals and can be overcome by stronger stimulation (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Found that ovariectomized female rats exhibited increased mRNA levels of estrogen receptor alpha (ERalpha) and estrogen receptor beta (ERbeta), and increased protein levels of GSK3beta but not GSK3alpha in brain cortical area, [RefSeq, PubMed]; He combined action of CHIR99021 and forskolin markedly delayed neurological deficits and significantly reduced the tumor volume. We suggest that reprogramming technology may be a potential treatment strategy replacing the therapeutic paradigm of traditional treatment of malignant glioma, and a combination molecule comprising a GSK3 inhibitor and a cAMP inducer could be the next generation of anticancer drugs. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0034236 protein kinase A catalytic subunit binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005102 signaling receptor binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005874 microtubule", "go_biological_process": "GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development;GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0006468 protein phosphorylation;GO:0007399 nervous system development;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P18265-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23514-1", "uniprot_id": [ { "id": "COPB_RAT", "url": "https://www.uniprot.org/uniprot/P23514", "type": "external" } ], "mass": 107011.0, "length": 953, "protein_name": "Coatomer subunit beta", "gene_name": "Copb1", "organism": "Rat", "refseq_name": "coatomer subunit beta", "refseq_ac": [ { "id": "NP_542959", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_542959", "type": "external" } ], "gene_names_uniprotkb": "Copb1; Copb", "gene_names_refseq": "Copb1", "protein_names_uniprotkb": "Coatomer subunit beta; Beta-COP; Beta-coat protein", "protein_names_refseq": "COPI coat complex subunit beta 1; beta-COP; beta-coat protein; coatomer protein complex, subunit beta 1; coatomer subunit beta; receptor for activated C-kinase-2", "tax_id": 10116, "disease": "", "pathway": " (rno:114023); (R-RNO-6798695); (R-RNO-6807878); (R-RNO-6811434)", "pathway_count": 4, "publication_count": 15, "publication_id_list": "10359600;10402461;12486083;15749703;17698811;1840503;18556652;19525381;1957170;20056612;21545355;8376457;8458872;9165027;9360998", "class_list": "", "function": "A(1)R stimulation of the heart is associated with PLC-initiated PKC-epsilon translocation and association with RACK2, [RefSeq, PubMed]; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Involved in the Golgi disassembly and reassembly processes during cell cycle. Involved in autophagy by playing a role in early endosome function. Plays a role in organellar compartmentalization of secretory compartments including endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC), Golgi, trans-Golgi network (TGN) and recycling endosomes, and in biosynthetic transport of CAV1. Plays a functional role in facilitating the transport of kappa-type opioid receptor mRNAs into axons and enhances translation of these proteins in the axonal compartment of dorsal root ganglion (DRG) cells. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005798 Golgi-associated vesicle;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0006891 intra-Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P23514-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24464-1", "uniprot_id": [ { "id": "CP4AC_RAT", "url": "https://www.uniprot.org/uniprot/P24464", "type": "external" } ], "mass": 58559.0, "length": 508, "protein_name": "Cytochrome P450 4A12", "gene_name": "Cyp4a12", "organism": "Rat", "refseq_name": "cytochrome P450 4A12", "refseq_ac": [ { "id": "NP_113793", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113793", "type": "external" } ], "gene_names_uniprotkb": "Cyp4a12; Cyp4a-8; Cyp4a8", "gene_names_refseq": "Cyp4a12; Cyp4a8", "protein_names_uniprotkb": "Cytochrome P450 4A12; 1.14.14.1; CYPIVA12; CYPIVA8; Cytochrome P450-KP1; Cytochrome P450-PP1", "protein_names_refseq": "CYPIVA12; CYPIVA8; P450-KP1; P450-PP1; cytochrome P450 4A12; cytochrome P450, 4a12; cytochrome P450-KP1; cytochrome P450-PP1", "tax_id": 10116, "disease": "autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); hypertension (Disease Ontology:DOID:10763)", "pathway": " (rno:266674); (R-RNO-211935); (R-RNO-211958); (R-RNO-211979); (R-RNO-2142691); (R-RNO-2142816)", "pathway_count": 6, "publication_count": 6, "publication_id_list": "10620324;10869363;11139583;15618658;18276983;1980193", "class_list": "", "function": "A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of saturated and unsaturated fatty acids (PubMed:10620324, PubMed:10869363, PubMed:15618658). May act as a major omega-hydroxylase for dodecanoic (lauric) acid in kidney (PubMed:10620324, PubMed:10869363, PubMed:15618658). At preglomerular arteries, may participate in omega-hydroxylation of (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) to 20-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure (PubMed:15618658). Can also catalyze the oxidation of the penultimate carbon (omega-1 oxidation) of fatty acids with lower efficiency, displaying a preference for the (R)-stereoisomer (PubMed:10869363). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:10620324, PubMed:10869363, PubMed:15618658)., [UniProtKB, PubMed, PubMed, PubMed]; Increased vascular tone brought about by induction of CYP4A8 and enhanced production of 20-HETE may constitute important factors in androgen-induced hypertension., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q642E9", "ec_number_list": [ { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" }, { "id": "1.14.14.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.-", "type": "external" }, { "id": "1.14.14.80", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.80", "type": "external" }, { "id": "1.14.14.79", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.79", "type": "external" }, { "id": "4.2.1.152", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.152", "type": "external" }, { "id": "1.14.13.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.n7", "type": "external" }, { "id": "1.14.14.94", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.94", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0004497 monooxygenase activity;GO:0052869 arachidonate omega-hydroxylase activity;GO:0018685 alkane 1-monooxygenase activity", "go_cellular_component": "GO:0043231 intracellular membrane-bounded organelle;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0046456 icosanoid biosynthetic process;GO:0006631 fatty acid metabolic process;GO:0001822 kidney development;GO:0043651 linoleic acid metabolic process;GO:0019369 arachidonate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P24464-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50393-1", "uniprot_id": [ { "id": "PA24A_RAT", "url": "https://www.uniprot.org/uniprot/P50393", "type": "external" } ], "mass": 85707.0, "length": 752, "protein_name": "Cytosolic phospholipase A2", "gene_name": "Pla2g4a", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pla2g4a; Cpla2; Pla2g4", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytosolic phospholipase A2; Phosphatidylcholine 2-acylhydrolase; Phospholipase A2 group IVA; cPLA2", "protein_names_refseq": "", "tax_id": 10116, "disease": "polycystic kidney disease (Disease Ontology:DOID:0080322); brain ischemia (Disease Ontology:DOID:2316); papilloma (Disease Ontology:DOID:2615); transitional cell carcinoma (Disease Ontology:DOID:2671); asthma (Disease Ontology:DOID:2841); hyperglycemia (Disease Ontology:DOID:4195)", "pathway": " (rno:24653); (R-RNO-111995); (R-RNO-1482788); (R-RNO-1482798); (R-RNO-1482801); (R-RNO-1482839); (R-RNO-1482922); (R-RNO-1482925); (R-RNO-1483115); (R-RNO-1483166); (R-RNO-2142753); (R-RNO-418592); (R-RNO-432142); (R-RNO-6811436)", "pathway_count": 14, "publication_count": 4, "publication_id_list": "22673903;29393594;7808237;9555100", "class_list": "", "function": "Has primarily calcium-dependent phospholipase and lysophospholipase activities, with a major role in membrane lipid remodeling and biosynthesis of lipid mediators of the inflammatory response (By similarity). Plays an important role in embryo implantation and parturition through its ability to trigger prostanoid production (By similarity). Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity). Selectively hydrolyzes sn-2 arachidonoyl group from membrane phospholipids, providing the precursor for eicosanoid biosynthesis via the cyclooxygenase pathway. In an alternative pathway of eicosanoid biosynthesis, hydrolyzes sn-2 fatty acyl chain of eicosanoid lysophopholipids to release free bioactive eicosanoids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-1 position of phospholipids (phospholipase A1 activity) only if an ether linkage rather than an ester linkage is present at the sn-2 position. This hydrolysis is not stereospecific. Has calcium-independent phospholipase A2 and lysophospholipase activities in the presence of phosphoinositides. Has O-acyltransferase activity. Catalyzes the transfer of fatty acyl chains from phospholipids to a primary hydroxyl group of glycerol (sn-1 or sn-3), potentially contributing to monoacylglycerol synthesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.1", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "2.3.1.43", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.43", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "2.3.1.149", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.149", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" } ], "go_molecular_function": "GO:0010314 phosphatidylinositol-5-phosphate binding;GO:0005509 calcium ion binding;GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0004623 phospholipase A2 activity;GO:0005544 calcium-dependent phospholipid binding", "go_cellular_component": "GO:0042588 zymogen granule;GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005737 cytoplasm", "go_biological_process": "GO:0006663 platelet activating factor biosynthetic process;GO:0043032 positive regulation of macrophage activation;GO:0034638 phosphatidylcholine catabolic process;GO:0046456 icosanoid biosynthetic process;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P50393-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56261-1", "uniprot_id": [ { "id": "CEBPE_RAT", "url": "https://www.uniprot.org/uniprot/P56261", "type": "external" } ], "mass": 30590.0, "length": 281, "protein_name": "CCAAT/enhancer-binding protein epsilon", "gene_name": "Cebpe", "organism": "Rat", "refseq_name": "CCAAT/enhancer-binding protein epsilon", "refseq_ac": [ { "id": "NP_058791", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058791", "type": "external" } ], "gene_names_uniprotkb": "Cebpe; Crp1", "gene_names_refseq": "C/EPBe; CRP1; Cebpe", "protein_names_uniprotkb": "CCAAT/enhancer-binding protein epsilon; C/EBP epsilon; C/EBP-related protein 1", "protein_names_refseq": "CCAAT/enhancer binding protein (C/EBP), epsilon; CCAAT/enhancer binding protein, epsilon; CCAAT/enhancer-binding protein epsilon; c/EBP epsilon; c/EBP-related protein 1", "tax_id": 10116, "disease": "immunodeficiency 108 (Disease Ontology:DOID:0061077)", "pathway": " (rno:25410)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "1884998;9593684", "class_list": "", "function": "Transcriptional activator. C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Required for the promyelocyte-myelocyte transition in myeloid differentiation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0030851 granulocyte differentiation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P56261-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62994-1", "uniprot_id": [ { "id": "GRB2_RAT", "url": "https://www.uniprot.org/uniprot/P62994", "type": "external" } ], "mass": 25206.0, "length": 217, "protein_name": "Growth factor receptor-bound protein 2", "gene_name": "Grb2", "organism": "Rat", "refseq_name": "growth factor receptor-bound protein 2", "refseq_ac": [ { "id": "NP_110473", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_110473", "type": "external" } ], "gene_names_uniprotkb": "Grb2; Ash", "gene_names_refseq": "Ash-psi; Grb2", "protein_names_uniprotkb": "Growth factor receptor-bound protein 2; Adapter protein GRB2; Protein Ash; SH2/SH3 adapter GRB2", "protein_names_refseq": "SH2/SH3 adapter GRB2; adapter protein GRB2; growth factor receptor-bound protein 2-like; growth factor receptor-bound protein 2; protein Ash", "tax_id": 10116, "disease": "autosomal recessive nonsyndromic deafness 114 (Disease Ontology:DOID:0111642); prostate cancer (Disease Ontology:DOID:10283); breast cancer (Disease Ontology:DOID:1612); prostate adenocarcinoma (Disease Ontology:DOID:2526); endometrial carcinoma (Disease Ontology:DOID:2871)", "pathway": " (rno:81504); (R-RNO-109704); (R-RNO-112412); (R-RNO-1250347); (R-RNO-1257604); (R-RNO-1295596); (R-RNO-1433557); (R-RNO-1433559); (R-RNO-167044); (R-RNO-179812); (R-RNO-180292); (R-RNO-180336); (R-RNO-182971); (R-RNO-186763); (R-RNO-1963640); (R-RNO-1963642); (R-RNO-2029482); (R-RNO-210993); (R-RNO-2179392); (R-RNO-2424491); (R-RNO-2428933); (R-RNO-2730905); (R-RNO-2871796); (R-RNO-2871809); (R-RNO-354194); (R-RNO-375165); (R-RNO-389359); (R-RNO-391160); (R-RNO-5654688); (R-RNO-5654689); (R-RNO-5654693); (R-RNO-5654695); (R-RNO-5654699); (R-RNO-5654700); (R-RNO-5654704); (R-RNO-5654706); (R-RNO-5654710); (R-RNO-5654712); (R-RNO-5654719); (R-RNO-5654720); (R-RNO-5654726); (R-RNO-5654727); (R-RNO-5654732); (R-RNO-5654733); (R-RNO-5663213); (R-RNO-5673001); (R-RNO-6807004); (R-RNO-6811558); (R-RNO-74749); (R-RNO-74751); (R-RNO-8851805); (R-RNO-8851907); (R-RNO-8853659); (R-RNO-8856825); (R-RNO-8856828); (R-RNO-8865999); (R-RNO-8875555); (R-RNO-8875656); (R-RNO-8983432); (R-RNO-9013420); (R-RNO-9027284); (R-RNO-9028731); (R-RNO-912526); (R-RNO-912631); (R-RNO-9607240); (R-RNO-9674555); (R-RNO-983695); (R-RNO-9842663); (R-RNO-9927353)", "pathway_count": 69, "publication_count": 7, "publication_id_list": "1384039;28065675;28618656;32652777;7775428;8262059;8388384", "class_list": "", "function": "A radical increase in the phosphorylation of IRS2 at serine 731 prevents the recruitment of GRB2 adaptor protein which may fail further to connect the Ras and other pathways required to the cell for its survival and to maintain integrity, [RefSeq, PubMed]; GRB2 plays an important role in CCl4-induced hepatic fibrosis by regulating hepatic stellate cell function, and up-regulation of GRB2 induced by HMGB1 is mediated via the PI3K/AKT pathway., [RefSeq, PubMed]; Low-magnitude vibration induces osteogenic differentiation of bone marrow mesenchymal stem cells via miR-378a-3p/Grb2 pathway to promote bone formation in a rat model of age-related bone loss., [RefSeq, PubMed]; Non-enzymatic adapter protein that plays a pivotal role in precisely regulated signaling cascades from cell surface receptors to cellular responses, including signaling transduction and gene expression (PubMed:7775428). Thus, participates in many biological processes including regulation of innate and adaptive immunity, autophagy, DNA repair or necroptosis. Controls signaling complexes at the T-cell antigen receptor to facilitate the activation, differentiation, and function of T-cells. Mechanistically, engagement of the TCR leads to phosphorylation of the adapter protein LAT, which serves as docking site for GRB2. In turn, GRB2 establishes a a connection with SOS1 that acts as a guanine nucleotide exchange factor and serves as a critical regulator of KRAS/RAF1 leading to MAPKs translocation to the nucleus and activation. Also plays a role in B-cell activation by amplifying Ca(2+) mobilization and activation of the ERK MAP kinase pathway upon recruitment to the phosphorylated B-cell antigen receptor (BCR). Plays a role in switching between autophagy and programmed necrosis upstream of EGFR by interacting with components of necrosomes including RIPK1 and with autophagy regulators SQSTM1 and BECN1. Regulates miRNA biogenesis by forming a functional ternary complex with AGO2 and DICER1. Functions in the replication stress response by protecting DNA at stalled replication forks from MRE11-mediated degradation. Mechanistically, inhibits RAD51 ATPase activity to stabilize RAD51 on stalled replication forks. Additionally, directly recruits and later releases MRE11 at DNA damage sites during the homology-directed repair (HDR) process., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P29354;Q14450;Q5BKA7;Q63057;Q63059", "ec_number_list": [], "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0017124 SH3 domain binding;GO:0019899 enzyme binding;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0007165 signal transduction;GO:0030154 cell differentiation;GO:0031623 receptor internalization;GO:0042110 T cell activation;GO:0042552 myelination", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P62994-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63007-1", "uniprot_id": [ { "id": "LHX1_RAT", "url": "https://www.uniprot.org/uniprot/P63007", "type": "external" } ], "mass": 44780.0, "length": 406, "protein_name": "LIM/homeobox protein Lhx1", "gene_name": "Lhx1", "organism": "Rat", "refseq_name": "LIM/homeobox protein Lhx1", "refseq_ac": [ { "id": "NP_665887", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665887", "type": "external" } ], "gene_names_uniprotkb": "Lhx1; Lim-1; Lim1", "gene_names_refseq": "Lhx1", "protein_names_uniprotkb": "LIM/homeobox protein Lhx1; Homeobox protein Lim-1; LIM homeobox protein 1; Rlim", "protein_names_refseq": "LIM homeobox protein 1; LIM/homeobox protein Lhx1; homeobox protein Lim-1; rlim", "tax_id": 10116, "disease": "", "pathway": " (rno:257634)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22673903;7914684;8793615", "class_list": "", "function": "Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P36199", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987 cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0032991 protein-containing complex", "go_biological_process": "GO:0060059 embryonic retina morphogenesis in camera-type eye;GO:0060429 epithelium development;GO:0072164 mesonephric tubule development;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007267 cell-cell signaling", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P63007-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BK39-1", "uniprot_id": [ { "id": "CP054_RAT", "url": "https://www.uniprot.org/uniprot/Q5BK39", "type": "external" } ], "mass": 24504.0, "length": 225, "protein_name": "Transmembrane protein C16orf54 homolog", "gene_name": "C1h16orf54", "organism": "Rat", "refseq_name": "transmembrane protein C16orf54 homolog", "refseq_ac": [ { "id": "NP_001020172", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020172", "type": "external" } ], "gene_names_uniprotkb": "C1h16orf54", "gene_names_refseq": "C1h16orf54", "protein_names_uniprotkb": "Transmembrane protein C16orf54 homolog", "protein_names_refseq": "transmembrane protein C16orf54 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:308990)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5BK39-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5I0D6-1", "uniprot_id": [ { "id": "NOSTN_RAT", "url": "https://www.uniprot.org/uniprot/Q5I0D6", "type": "external" } ], "mass": 57352.0, "length": 502, "protein_name": "Nostrin", "gene_name": "Nostrin", "organism": "Rat", "refseq_name": "nostrin", "refseq_ac": [ { "id": "NP_001019431", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019431", "type": "external" } ], "gene_names_uniprotkb": "Nostrin", "gene_names_refseq": "Nostrin", "protein_names_uniprotkb": "Nostrin; BM247; Nitric oxide synthase trafficker; eNOS-trafficking inducer", "protein_names_refseq": "BM247; eNOS-trafficking inducer; nitric oxide synthase trafficker; nostrin", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061)", "pathway": " (rno:311111); (R-RNO-203641)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "11489260;16234328;22673903", "class_list": "", "function": "Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q923J7", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0006897 endocytosis;GO:0007165 signal transduction;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5I0D6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63699-1", "uniprot_id": [ { "id": "CDK2_RAT", "url": "https://www.uniprot.org/uniprot/Q63699", "type": "external" } ], "mass": 33887.0, "length": 298, "protein_name": "Cyclin-dependent kinase 2", "gene_name": "Cdk2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cdk2; Cdkn2", "gene_names_refseq": "", "protein_names_uniprotkb": "Cyclin-dependent kinase 2; 2.7.11.22; Cell division protein kinase 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283); interstitial cystitis (Disease Ontology:DOID:13949); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); membranoproliferative glomerulonephritis (Disease Ontology:DOID:2920); renal cell carcinoma (Disease Ontology:DOID:4450)", "pathway": " (rno:362817); (R-RNO-1538133); (R-RNO-171319); (R-RNO-176187); (R-RNO-176408); (R-RNO-187577); (R-RNO-2559582); (R-RNO-2559586); (R-RNO-5693607); (R-RNO-6804116); (R-RNO-6804756); (R-RNO-6804757); (R-RNO-68911); (R-RNO-68949); (R-RNO-68962); (R-RNO-69017); (R-RNO-69200); (R-RNO-69202); (R-RNO-69231); (R-RNO-69273); (R-RNO-69563); (R-RNO-69656); (R-RNO-8849470); (R-RNO-9616222)", "pathway_count": 24, "publication_count": 3, "publication_id_list": "10542199;7862443;8673024", "class_list": "", "function": "Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis (By similarity). Phosphorylates CABLES1, CTNNB1, CDK2AP2, ERCC6, NBN, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, SUV39H1, EZH2 (PubMed:10542199). Triggers duplication of centrosomes and DNA (By similarity). Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus (By similarity). Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in embryonic stem cells (ESCs) (By similarity). Activated by the CDK-activating kinase (CAK) complex consisting of CDK7, cyclin-H/CCNH and MAT1, which is a master regulator of CDK activity (By similarity). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase (By similarity). EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC (By similarity). Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis (By similarity). In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation (By similarity). Involved in regulation of telomere repair by mediating phosphorylation of NBN (By similarity). Phosphorylation of RB1 disturbs its interaction with E2F1 (By similarity). NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociation from unduplicated centrosomes, thus initiating centrosome duplication (By similarity). Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase (By similarity). Required for vitamin D-mediated growth inhibition by being itself inactivated (By similarity). Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner (By similarity). USP37 is activated by phosphorylation and thus triggers G1-S transition (By similarity). CTNNB1 phosphorylation regulates insulin internalization (By similarity). Phosphorylates FOXP3 and negatively regulates its transcriptional activity and protein stability (By similarity). Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (By similarity). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of the C-terminus of protein kinase B (PKB/AKT1 and PKB/AKT2), promoting its activation (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O09136", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.7.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.-", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "5.4.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.-", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005768 endosome", "go_biological_process": "GO:0043247 telomere maintenance in response to DNA damage;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006281 DNA repair;GO:0006338 chromatin remodeling;GO:0006468 protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q63699-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q641X2-1", "uniprot_id": [ { "id": "LEO1_RAT", "url": "https://www.uniprot.org/uniprot/Q641X2", "type": "external" } ], "mass": 76957.0, "length": 678, "protein_name": "RNA polymerase-associated protein LEO1", "gene_name": "Leo1", "organism": "Rat", "refseq_name": "RNA polymerase-associated protein LEO1", "refseq_ac": [ { "id": "NP_001005548", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005548", "type": "external" } ], "gene_names_uniprotkb": "Leo1", "gene_names_refseq": "Leo1", "protein_names_uniprotkb": "RNA polymerase-associated protein LEO1", "protein_names_refseq": "LEO1 homolog, Paf1/RNA polymerase II complex component; Leo1 Paf1/RNA polymerase II complex component; RNA polymerase-associated protein LEO1", "tax_id": 10116, "disease": "", "pathway": " (rno:300837); (R-RNO-112382); (R-RNO-201722); (R-RNO-674695); (R-RNO-75955); (R-RNO-8866654); (R-RNO-9943411)", "pathway_count": 7, "publication_count": 2, "publication_id_list": "16641100;22673903", "class_list": "", "function": "Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. Involved in polyadenylation of mRNA precursors. Connects PAF1C to Wnt signaling (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 29, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990269 RNA polymerase II C-terminal domain phosphoserine binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0001650 fibrillar center;GO:0016593 Cdc73/Paf1 complex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0016055 Wnt signaling pathway;GO:0019827 stem cell population maintenance;GO:0006368 transcription elongation by RNA polymerase II;GO:0001711 endodermal cell fate commitment", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q641X2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O89038-1", "uniprot_id": [ { "id": "MEF2D_RAT", "url": "https://www.uniprot.org/uniprot/O89038", "type": "external" } ], "mass": 54368.0, "length": 507, "protein_name": "Myocyte-specific enhancer factor 2D", "gene_name": "Mef2d", "organism": "Rat", "refseq_name": "myocyte-specific enhancer factor 2D", "refseq_ac": [ { "id": "NP_110487", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_110487", "type": "external" } ], "gene_names_uniprotkb": "Mef2d", "gene_names_refseq": "Mef2d", "protein_names_uniprotkb": "Myocyte-specific enhancer factor 2D", "protein_names_refseq": "myocyte-specific enhancer factor 2D", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); intellectual disability (Disease Ontology:DOID:1059); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); lung cancer (Disease Ontology:DOID:1324)", "pathway": " (rno:81518); (R-RNO-525793)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "22673903;28473466;28807675;30523159;34232128;34502162;9753748", "class_list": "", "function": "MEF2A and MEF2D were absolutely required for cardiomyocyte survival, whereas MEF2C, despite its major role in cardiac morphogenesis and direct reprogramming, was dispensable for this process., [RefSeq, PubMed]; Neuroprotection against 1-Methyl-4-phenylpyridinium-induced cytotoxicity by naturally occurring polydatin through activation of transcription factor MEF2D., [RefSeq, PubMed]; Study suggests that SU4312 provides therapeutic benefits in cellular and animal models of Parkinson's disease, possibly through multiple mechanisms including enhancement of myocyte enhancer factor 2D through the activation of PI3-K/Akt pathway., [RefSeq, PubMed]; These results highlight the importance of mAKAPbeta signalosomes for regulating MEF2D activity in striated muscle, affirming mAKAPbeta as a nodal regulator in the myocyte intracellular signaling network., [RefSeq, PubMed]; Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q66HL8", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0019899 enzyme binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O89038-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q924I2-1", "uniprot_id": [ { "id": "M4K3_RAT", "url": "https://www.uniprot.org/uniprot/Q924I2", "type": "external" } ], "mass": 98679.0, "length": 873, "protein_name": "Mitogen-activated protein kinase kinase kinase kinase 3", "gene_name": "Map4k3", "organism": "Rat", "refseq_name": "mitogen-activated protein kinase kinase kinase kinase 3", "refseq_ac": [ { "id": "NP_596898", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_596898", "type": "external" } ], "gene_names_uniprotkb": "Map4k3", "gene_names_refseq": "Map4k3", "protein_names_uniprotkb": "Mitogen-activated protein kinase kinase kinase kinase 3; 2.7.11.1; GLK; Germinal center kinase-related protein kinase; MAPK/ERK kinase kinase kinase 3; MEK kinase kinase 3; MEKKK 3", "protein_names_refseq": "GLK; MAPK/ERK kinase kinase kinase 3; MEK kinase kinase 3; MEKKK 3; germinal center kinase-related protein kinase; mitogen-activated protein kinase kinase kinase kinase 3", "tax_id": 10116, "disease": "ciliopathy (Disease Ontology:DOID:0060340); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (rno:170920)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11384986;28731988", "class_list": "", "function": "MAP4K3 positively regulates preterm skeletal muscle satellite cell myogenesis, but may not regulate mTORC1 activity. MAP4K3 may play a role in mTORC1 full activation in response to leucine. Publication Status: Online-Only, [RefSeq, PubMed]; Serine/threonine kinase that plays a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0017124 SH3 domain binding;GO:0008349 MAP kinase kinase kinase kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0034612 response to tumor necrosis factor;GO:0035556 intracellular signal transduction;GO:0009411 response to UV", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q924I2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13264-1", "uniprot_id": [ { "id": "GLSK_RAT", "url": "https://www.uniprot.org/uniprot/P13264", "type": "external" } ], "mass": 74024.0, "length": 674, "protein_name": "Glutaminase kidney isoform, mitochondrial", "gene_name": "Gls", "organism": "Rat", "refseq_name": "glutaminase kidney isoform, mitochondrial isoform a", "refseq_ac": [ { "id": "NP_036701", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036701", "type": "external" } ], "gene_names_uniprotkb": "Gls", "gene_names_refseq": "Gls; Glut; RATGLUT", "protein_names_uniprotkb": "Glutaminase kidney isoform, mitochondrial; 3.5.1.2; GLS; K-glutaminase; L-glutamine amidohydrolase", "protein_names_refseq": "K-glutaminase; L-glutamine amidohydrolase; glutaminase kidney isoform, mitochondrial isoform a; kidney-type glutaminase", "tax_id": 10116, "disease": "aspiration pneumonia (Disease Ontology:DOID:0050152); obstructive sleep apnea (Disease Ontology:DOID:0050848); glomerulosclerosis (Disease Ontology:DOID:0050851); renal fibrosis (Disease Ontology:DOID:0050855); non-arteritic anterior ischemic optic neuropathy (Disease Ontology:DOID:0050864); coarctation of the aorta (Disease Ontology:DOID:0051054); stroke (Disease Ontology:DOID:0051061); pre-malignant neoplasm (Disease Ontology:DOID:0060071); atrial fibrillation (Disease Ontology:DOID:0060224); CASGID syndrome (Disease Ontology:DOID:0061156); alcohol-associated liver disease (Disease Ontology:DOID:0070658); Coronavirus infectious disease (Disease Ontology:DOID:0080599); COVID-19 (Disease Ontology:DOID:0080600); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); focal segmental glomerulosclerosis 1 (Disease Ontology:DOID:0111128); developmental and epileptic encephalopathy 71 (Disease Ontology:DOID:0112207); stomach cancer (Disease Ontology:DOID:10534); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); nephritis (Disease Ontology:DOID:10952); IgA vasculitis (Disease Ontology:DOID:11123); sarcoidosis (Disease Ontology:DOID:11335); pyelonephritis (Disease Ontology:DOID:11400); osteoporosis (Disease Ontology:DOID:11476); diabetic angiopathy (Disease Ontology:DOID:11713); nephrotic syndrome (Disease Ontology:DOID:1184); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); allergic disease (Disease Ontology:DOID:1205); primary biliary cholangitis (Disease Ontology:DOID:12236); leukemia (Disease Ontology:DOID:1240); hepatitis A (Disease Ontology:DOID:12549); dilated cardiomyopathy (Disease Ontology:DOID:12930); endomyocardial fibrosis (Disease Ontology:DOID:12932); leukostasis (Disease Ontology:DOID:12986); uveitis (Disease Ontology:DOID:13141); lung cancer (Disease Ontology:DOID:1324); Behcet's disease (Disease Ontology:DOID:13241); cholestasis (Disease Ontology:DOID:13580); toxic shock syndrome (Disease Ontology:DOID:14115); Fabry disease (Disease Ontology:DOID:14499); renovascular hypertension (Disease Ontology:DOID:1591); breast cancer (Disease Ontology:DOID:1612); anemia (Disease Ontology:DOID:2355); nephrosis (Disease Ontology:DOID:2527); bronchiolitis obliterans (Disease Ontology:DOID:2799); asthma (Disease Ontology:DOID:2841); glomerulonephritis (Disease Ontology:DOID:2921); IgA glomerulonephritis (Disease Ontology:DOID:2986); familial Mediterranean fever (Disease Ontology:DOID:2987); acute kidney failure (Disease Ontology:DOID:3021); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); lymphangioleiomyomatosis (Disease Ontology:DOID:3319); coronary artery disease (Disease Ontology:DOID:3393); gallbladder adenocarcinoma (Disease Ontology:DOID:3500); middle cerebral artery infarction (Disease Ontology:DOID:3525); cerebral infarction (Disease Ontology:DOID:3526); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); pulmonary fibrosis (Disease Ontology:DOID:3770); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); lung carcinoma (Disease Ontology:DOID:3905); heart valve disease (Disease Ontology:DOID:4079); systemic scleroderma (Disease Ontology:DOID:418); allergic rhinitis (Disease Ontology:DOID:4481); liver cirrhosis (Disease Ontology:DOID:5082); ureteral obstruction (Disease Ontology:DOID:5199); schizophrenia (Disease Ontology:DOID:5419); pneumonia (Disease Ontology:DOID:552); proteinuria (Disease Ontology:DOID:576); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); mitral valve disease (Disease Ontology:DOID:61); hepatocellular carcinoma (Disease Ontology:DOID:684); ankylosing spondylitis (Disease Ontology:DOID:7147); abdominal aortic aneurysm (Disease Ontology:DOID:7693); end stage renal disease (Disease Ontology:DOID:783); ocular hypotension (Disease Ontology:DOID:790); myocarditis (Disease Ontology:DOID:820); extrinsic allergic alveolitis (Disease Ontology:DOID:841); polycythemia (Disease Ontology:DOID:8432); lung disease (Disease Ontology:DOID:850); chronic myeloid leukemia (Disease Ontology:DOID:8552); intermediate coronary syndrome (Disease Ontology:DOID:8805); diabetic retinopathy (Disease Ontology:DOID:8947); subacute sclerosing panencephalitis (Disease Ontology:DOID:8970); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); type 1 diabetes mellitus (Disease Ontology:DOID:9744); diastolic heart failure (Disease Ontology:DOID:9775); mitral valve prolapse (Disease Ontology:DOID:988); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24398); (R-RNO-210500); (R-RNO-5628897); (R-RNO-8964539)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "11267668;12045296;16899818;1918000;1991024;22228304;22673903;23935106;28100784;28770953;31344597;3401701;36915976;7836378", "class_list": "", "function": "Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate, the main excitatory neurotransmitter in the brain., [UniProtKB, UniProtKB]; Inhibiting silence information regulator 2 and glutaminase in the amygdala can improve social behavior in autistic rats., [RefSeq, PubMed]; MiR-200c directly targets the glutaminase (GLS) through complimentary binding to the 3'UTR reagent of GLS., [RefSeq, PubMed]; TNFalpha increases STAT3-mediated expression of glutaminase isoform KGA in cultured rat astrocytes., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 91, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8R421", "ec_number_list": [ { "id": "6.3.4.16", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.16", "type": "external" }, { "id": "2.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.3.2", "type": "external" }, { "id": "3.5.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.3", "type": "external" }, { "id": "6.3.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.5.5", "type": "external" }, { "id": "3.5.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.2", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0004359 glutaminase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol;GO:0045202 synapse", "go_biological_process": "GO:0001967 suckling behavior;GO:0051289 protein homotetramerization;GO:0002087 regulation of respiratory gaseous exchange by nervous system process;GO:0007268 chemical synaptic transmission;GO:0006537 glutamate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P13264-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63342-1", "uniprot_id": [ { "id": "M2GD_RAT", "url": "https://www.uniprot.org/uniprot/Q63342", "type": "external" } ], "mass": 96048.0, "length": 857, "protein_name": "Dimethylglycine dehydrogenase, mitochondrial", "gene_name": "Dmgdh", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Dmgdh", "gene_names_refseq": "", "protein_names_uniprotkb": "Dimethylglycine dehydrogenase, mitochondrial; 1.5.8.4; ME2GLYDH", "protein_names_refseq": "", "tax_id": 10116, "disease": "dimethylglycine dehydrogenase deficiency (Disease Ontology:DOID:0081446); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (R-RNO-6798163)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "1710985;2417560;24858690;25954742;4055729", "class_list": "", "function": "Catalyzes the demethylation of N,N-dimethylglycine to sarcosine. Also has activity with sarcosine in vitro., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.5.8.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.8.4", "type": "external" } ], "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0005542 folic acid binding;GO:0047865 dimethylglycine dehydrogenase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0019695 choline metabolic process;GO:0042426 choline catabolic process;GO:0035999 tetrahydrofolate interconversion;GO:0006579 amino-acid betaine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q63342-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JMH2-1", "uniprot_id": [ { "id": "LRIT1_RAT", "url": "https://www.uniprot.org/uniprot/Q9JMH2", "type": "external" } ], "mass": 68417.0, "length": 623, "protein_name": "Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1", "gene_name": "Lrit1", "organism": "Rat", "refseq_name": "leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1 precursor", "refseq_ac": [ { "id": "NP_647547", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647547", "type": "external" } ], "gene_names_uniprotkb": "Lrit1; Lrrc21; Pal", "gene_names_refseq": "Lrit1; Lrrc21; Pal", "protein_names_uniprotkb": "Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1; Leucine-rich repeat-containing protein 21; Photoreceptor-associated LRR superfamily protein; Retina-specific protein PAL", "protein_names_refseq": "leucine rich repeat containing 21; leucine-rich repeat, immunoglobulin-like and transmembrane domains 1; leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1 precursor; leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1; leucine-rich repeat-containing protein 21; photoreceptor-associated LRR superfamily protein; putative type I transmembrane protein; retina specific glycoprotein; retina-specific protein PAL", "tax_id": 10116, "disease": "", "pathway": " (rno:246214)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10777785", "class_list": "", "function": "Photoreceptor synaptic protein essential for normal vision (By similarity). Involved in synapse formation in cone photoreceptor cells (By similarity)., [UniProtKB, UniProtKB]; Photoreceptor synaptic protein essential for normal vision. Involved in synapse formation in cone photoreceptor cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0030425 dendrite;GO:0045202 synapse;GO:0005789 endoplasmic reticulum membrane;GO:0043083 synaptic cleft", "go_biological_process": "GO:0007601 visual perception;GO:0009416 response to light stimulus;GO:0007602 phototransduction;GO:0099536 synaptic signaling", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9JMH2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2RRU1-1", "uniprot_id": [ { "id": "GYS1_RAT", "url": "https://www.uniprot.org/uniprot/A2RRU1", "type": "external" } ], "mass": 84072.0, "length": 738, "protein_name": "Glycogen [starch] synthase, muscle", "gene_name": "Gys1", "organism": "Rat", "refseq_name": "glycogen [starch] synthase, muscle", "refseq_ac": [ { "id": "NP_001103085", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103085", "type": "external" } ], "gene_names_uniprotkb": "Gys1", "gene_names_refseq": "Gys1", "protein_names_uniprotkb": "Glycogen [starch] synthase, muscle; 2.4.1.11; Glycogen synthase 1", "protein_names_refseq": "glycogen [starch] synthase, muscle; glycogen synthase 1, muscle", "tax_id": 10116, "disease": "cardiovascular system disease (Disease Ontology:DOID:1287); Lafora disease (Disease Ontology:DOID:3534)", "pathway": " (rno:690987); (R-RNO-3322077)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "19432592;20597590;22673903", "class_list": "glycogene;glycosyltransferase", "function": "After contraction insulin-stimulated glycogen synthesis was increased by rather similar magnitude at all glycogen contents in concert with increased glycogen synthase activation., [RefSeq, PubMed]; After contraction, glycogen synthase (GS) was increased to similar levels in muscles with low, normal and high glycogen content; rate of glycogen synthesis after contraction was also similar; insulin increased GS activation at all glycogen contents., [RefSeq, PubMed]; Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.18", "type": "external" }, { "id": "2.4.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.11", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" } ], "go_molecular_function": "GO:0004373 alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity;GO:0005536 D-glucose binding;GO:0061547 glycogen synthase activity, transferring glucose-1-phosphate", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:1902494 catalytic complex;GO:0016234 inclusion body", "go_biological_process": "GO:0007507 heart development;GO:0005977 glycogen metabolic process;GO:0005978 glycogen biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A2RRU1-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000001000.0000000000001.000.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08733-1", "uniprot_id": [ { "id": "MLRV_RAT", "url": "https://www.uniprot.org/uniprot/P08733", "type": "external" } ], "mass": 18880.0, "length": 166, "protein_name": "Myosin regulatory light chain 2, ventricular/cardiac muscle isoform", "gene_name": "Myl2", "organism": "Rat", "refseq_name": "myosin regulatory light chain 2, ventricular/cardiac muscle isoform", "refseq_ac": [ { "id": "NP_001030329", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030329", "type": "external" } ], "gene_names_uniprotkb": "Myl2; Mlc2", "gene_names_refseq": "MLC-2s/v; Mlc-2; Mlc2; Myl2", "protein_names_uniprotkb": "Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; MLC-2s/v; MLC-2v; MLC-2; Myosin light chain 2, slow skeletal/ventricular muscle isoform", "protein_names_refseq": "cardiac myosin light chain-2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform; myosin, light chain 2, regulatory, cardiac, slow; myosin, light polypeptide 2, regulatory, cardiac, slow", "tax_id": 10116, "disease": "infantile-onset myofibrillar myopathy 12 with cardiomyopathy (Disease Ontology:DOID:0051044); familial hypertrophic cardiomyopathy (Disease Ontology:DOID:0080326); hypertrophic cardiomyopathy 10 (Disease Ontology:DOID:0110316)", "pathway": " (rno:363925); (R-RNO-390522)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "1379240;15331360;16431080;17885681;18988896;22673903;24477671;25982880;27748856;2808370;3005270;30161304;3380697;34502162;34594239;38474189", "class_list": "", "function": "Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (PubMed:15331360). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly (By similarity)., [UniProtKB, PubMed, UniProtKB]; Nuclear MYL2 plays an important role in IR injury by transcriptionally upregulating NOX2 expression to enhance oxidative stress in a phosphorylation-dependent manner., [RefSeq, PubMed]; Phosphorylated CPI-17 and MLC2 as Biomarkers of Coronary Artery Spasm-Induced Sudden Cardiac Death. Publication Status: Online-Only, [RefSeq, PubMed]; Silencing MLCII by RNA interference reduced ALP activity (P<0.01), and eliminated RUNX2 mRNA expression (P<0.01). Addition of the MLC kinase inhibitor, ML7, reduced the CUCSassociated upregulation of RUNX2 expression (P<0.01) and ALP activity (P<0.01)., [RefSeq, PubMed]; The MYL2 gene may be involved in the proliferation of spermatogonial stem cells and the process of sperm cells developing into mature sperm., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0JMZ7", "ec_number_list": [], "go_molecular_function": "GO:0003785 actin monomer binding;GO:0005509 calcium ion binding;GO:0008307 structural constituent of muscle", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0015629 actin cytoskeleton;GO:0030016 myofibril;GO:0031672 A band", "go_biological_process": "GO:0007507 heart development;GO:0060047 heart contraction;GO:0003007 heart morphogenesis;GO:0009791 post-embryonic development;GO:0030308 negative regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P08733-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A875-1", "uniprot_id": [ { "id": "D4A875_RAT", "url": "https://www.uniprot.org/uniprot/D4A875", "type": "external" } ], "mass": 13803.0, "length": 119, "protein_name": "C-X-C motif chemokine ligand 17", "gene_name": "Cxcl17", "organism": "Rat", "refseq_name": "C-X-C motif chemokine 17 precursor", "refseq_ac": [ { "id": "NP_001100961", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100961", "type": "external" } ], "gene_names_uniprotkb": "Cxcl17", "gene_names_refseq": "Cxcl17; RGD1304717", "protein_names_uniprotkb": "C-X-C motif chemokine ligand 17", "protein_names_refseq": "C-X-C motif chemokine 17 precursor; C-X-C motif chemokine 17; VEGF co-regulated chemokine 1; VEGF coregulated chemokine 1; chemokine (C-X-C motif) ligand 17", "tax_id": 10116, "disease": "", "pathway": " (rno:308436)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23115081", "class_list": "", "function": "CXCL17 in the gastric lamina propria may play an important role in tissue repair and anti-inflammation, both of which help to maintain the integrity of the gastric mucosa., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042056 chemoattractant activity;GO:0008009 chemokine activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0016477 cell migration;GO:0070098 chemokine-mediated signaling pathway;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0090026 positive regulation of monocyte chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4A875-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A8G3-1", "uniprot_id": [ { "id": "LURA1_RAT", "url": "https://www.uniprot.org/uniprot/D4A8G3", "type": "external" } ], "mass": 25891.0, "length": 239, "protein_name": "Leucine rich adaptor protein 1", "gene_name": "Lurap1", "organism": "Rat", "refseq_name": "leucine rich adaptor protein 1", "refseq_ac": [ { "id": "NP_001102733", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102733", "type": "external" } ], "gene_names_uniprotkb": "Lurap1; Lrap35a; Lrp35a", "gene_names_refseq": "LRAP35a; Lrp35a; Lurap1; RGD1566001", "protein_names_uniprotkb": "Leucine rich adaptor protein 1; Leucine repeat adapter protein 35A", "protein_names_refseq": "NF-kappa-B activator C1orf190 homolog; adaptor protein LRAP35a; leucine repeat adapter protein 35A; leucine rich adaptor protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:500527)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "18854160;22673903;25107909", "class_list": "", "function": "Acts as an activator of the canonical NF-kappa-B pathway and drive the production of pro-inflammatory cytokines. Promotes the antigen (Ag)-presenting and priming function of dendritic cells via the canonical NF-kappa-B pathway (By similarity). In concert with MYO18A and CDC42BPA/CDC42BPB, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Activates CDC42BPA/CDC42BPB and targets it to actomyosin through its interaction with MYO18A, leading to MYL9/MLC2 phosphorylation and MYH9/MYH10-dependent actomyosin assembly in the lamella., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0042641 actomyosin", "go_biological_process": "GO:0016477 cell migration;GO:0001819 positive regulation of cytokine production;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0031032 actomyosin structure organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D4A8G3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30191-1", "uniprot_id": [ { "id": "GBRA6_RAT", "url": "https://www.uniprot.org/uniprot/P30191", "type": "external" } ], "mass": 51184.0, "length": 453, "protein_name": "Gamma-aminobutyric acid receptor subunit alpha-6", "gene_name": "Gabra6", "organism": "Rat", "refseq_name": "gamma-aminobutyric acid receptor subunit alpha-6 precursor", "refseq_ac": [ { "id": "NP_068613", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068613", "type": "external" } ], "gene_names_uniprotkb": "Gabra6; Gabra-6", "gene_names_refseq": "Gabra6", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit alpha-6; GABA(A) receptor subunit alpha-6; GABAAR subunit alpha-6", "protein_names_refseq": "GABA(A) receptor subunit alpha-6; GABA-A receptor alpha-6 subunit; GABAAR subunit alpha-6; gamma-aminobutyric acid (GABA) A receptor, alpha 6; gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 6; gamma-aminobutyric acid A receptor, alpha 6; gamma-aminobutyric acid receptor subunit alpha-6 precursor; gamma-aminobutyric acid receptor subunit alpha-6; gamma-aminobutyric acid type A receptor alpha 6 subunit", "tax_id": 10116, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:29708); (R-RNO-977443)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "2166916;22673903;25128322;27388150;34332026;9464994", "class_list": "", "function": "Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:2166916, PubMed:9464994). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). Alpha-6/GABRA6 subunits are found at both synaptic and extrasynaptic sites (PubMed:2166916, PubMed:9464994). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity). Extrasynaptic alpha-6-containing receptors contribute to the tonic GABAergic inhibition (PubMed:9464994). Alpha-6 subunits are also present on glutamatergic synapses (PubMed:9464994)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; Gabra6100Q allele Sprague-Dawley rats have a higher sensitivity to hypnosis induced by isoflurane and ethanol than the wild type rats., [RefSeq, PubMed]; Results indicate that the Gabra6-containing GABAA receptor is a key modulator of hippocampal synaptic transmission and likely plays a crucial role in the pathophysiology of maternal separation-induced depression., [RefSeq, PubMed]; Results suggest estradiol decreased the orofacial nociceptive response, in part, by causing an increase in Gabralpha6 expression., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0005254 chloride channel activity;GO:0050809 diazepam binding;GO:0004890 GABA-A receptor activity;GO:0005237 inhibitory extracellular ligand-gated monoatomic ion channel activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0043235 receptor complex;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0045471 response to ethanol;GO:0007214 gamma-aminobutyric acid signaling pathway;GO:1902476 chloride transmembrane transport;GO:0051932 synaptic transmission, GABAergic;GO:1904862 inhibitory synapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P30191-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80WL1-1", "uniprot_id": [ { "id": "GLDN_RAT", "url": "https://www.uniprot.org/uniprot/Q80WL1", "type": "external" } ], "mass": 59330.0, "length": 549, "protein_name": "Gliomedin", "gene_name": "Gldn", "organism": "Rat", "refseq_name": "gliomedin", "refseq_ac": [ { "id": "NP_852047", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_852047", "type": "external" } ], "gene_names_uniprotkb": "Gldn", "gene_names_refseq": "Colm; Crgl2; Gldn", "protein_names_uniprotkb": "Gliomedin", "protein_names_refseq": "collomin; gliomedin; olfactomedin-related protein", "tax_id": 10116, "disease": "lethal congenital contracture syndrome (Disease Ontology:DOID:0060558)", "pathway": " (rno:315675)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16039564;17485493;22009740;22885108;25372825;25525261", "class_list": "", "function": "Ligand for NRCAM and NFASC/neurofascin that plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Mediates interaction between Schwann cell microvilli and axons via its interactions with NRCAM and NFASC (PubMed:16039564). Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with NRCAM, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier (By similarity)., [UniProtKB, PubMed, UniProtKB]; Primary immune reaction against gliomedin, a peripheral nervous system adhesion molecule, can be responsible for the initiation or progression of the demyelinating form of Guillain-Barre syndrome., [RefSeq, PubMed]; The crystallization of the rat GLDN olfactomedin domain was expressed in an insect-cell system., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0086080 protein binding involved in heterotypic cell-cell adhesion", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030424 axon", "go_biological_process": "GO:0007165 signal transduction;GO:0045162 clustering of voltage-gated sodium channels;GO:0032528 microvillus organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q80WL1-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07722-1", "uniprot_id": [ { "id": "MAG_RAT", "url": "https://www.uniprot.org/uniprot/P07722", "type": "external" } ], "mass": 69353.0, "length": 626, "protein_name": "Myelin-associated glycoprotein", "gene_name": "Mag", "organism": "Rat", "refseq_name": "myelin-associated glycoprotein precursor", "refseq_ac": [ { "id": "NP_058886", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058886", "type": "external" } ], "gene_names_uniprotkb": "Mag", "gene_names_refseq": "1B236; Mag", "protein_names_uniprotkb": "Myelin-associated glycoprotein; 1B236; Brain neuron cytoplasmic protein 3; Sialic acid-binding Ig-like lectin 4a; Siglec-4a", "protein_names_refseq": "S-MAG (C-term.); brain neuron cytoplasmic protein 3; myelin-associated glycoprotein precursor; sialic acid-binding Ig-like lectin 4a; siglec-4a", "tax_id": 10116, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); hereditary spastic paraplegia 75 (Disease Ontology:DOID:0110820); sciatic neuropathy (Disease Ontology:DOID:11446); multiple sclerosis (Disease Ontology:DOID:2377); middle cerebral artery infarction (Disease Ontology:DOID:3525); nerve compression syndrome (Disease Ontology:DOID:573)", "pathway": " (rno:29409); (R-RNO-193634); (R-RNO-210991)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "16998591;1703542;17640868;19158290;19367338;19420245;22673903;2432614;2435742;2438699;31985825;4020419;6347394;6586369;8995428;9298990", "class_list": "", "function": "Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2 (PubMed:8995428, PubMed:9298990). Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination. Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane (By similarity). Negative regulator of neurite outgrowth; in dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides (PubMed:17640868). In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides (PubMed:17640868). In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides (PubMed:19367338). Inhibits axon longitudinal growth (PubMed:9298990). Inhibits axon outgrowth by binding to RTN4R (By similarity). Preferentially binds to alpha-2,3-linked sialic acid (PubMed:8995428). Binds ganglioside Gt1b (PubMed:8995428)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Myelin-associated glycoprotein inhibits neurite outgrowth through inactivation of the small GTPase Rap1., [RefSeq, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "P02685;P07723", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0019901 protein kinase binding;GO:0042803 protein homodimerization activity;GO:0030246 carbohydrate binding;GO:0033691 sialic acid binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043209 myelin sheath;GO:0045121 membrane raft;GO:0035749 myelin sheath adaxonal region;GO:0043220 Schmidt-Lanterman incisure", "go_biological_process": "GO:0032289 central nervous system myelin formation;GO:0007155 cell adhesion;GO:0007399 nervous system development;GO:0022010 central nervous system myelination;GO:0045665 negative regulation of neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P07722-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R080-1", "uniprot_id": [ { "id": "GPSM1_RAT", "url": "https://www.uniprot.org/uniprot/Q9R080", "type": "external" } ], "mass": 74440.0, "length": 673, "protein_name": "G protein-signaling modulator 1", "gene_name": "Gpsm1", "organism": "Rat", "refseq_name": "G-protein-signaling modulator 1 isoform b", "refseq_ac": [ { "id": "NP_001138941", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138941", "type": "external" } ], "gene_names_uniprotkb": "Gpsm1; Ags3", "gene_names_refseq": "Ags3; Gpsm1", "protein_names_uniprotkb": "G protein-signaling modulator 1; Activator of G protein signaling 3", "protein_names_refseq": "G-protein signaling modulator 1 (AGS3-like, C. elegans); G-protein signalling modulator 1 (AGS3-like, C. elegans); G-protein-signaling modulator 1 isoform b; activator of G-protein signaling 3", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); brain cancer (Disease Ontology:DOID:1319); cancer (Disease Ontology:DOID:162)", "pathway": " (rno:246254); (R-RNO-418594)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "10559191;10969064;11042168;11121039;11278352;11832491;12719437;12834360;14726514;15091342;15937104;16154268;20305814;21343176;22673903;23404409;23504261", "class_list": "", "function": "AGS3 reduced D(2L)DR-mediated sensitization of AC1 and AC2., [RefSeq, PubMed]; Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Levels of AGS3 and USP9x are co-regulated in the prefrontal cortex of rats withdrawn from repeated cocaine treatment Publication Status: Online-Only, [RefSeq, PubMed]; The GPR motif in this protein and other proteins is actually associated with activity as a GDI - guanine nucleotide dissociation inhibitor and not GTPase activator as initially suggested., [RefSeq, PubMed]; These data suggest that Gpsm1 acts through a novel receptor-independent mechanism to facilitate renal tubular epithelial cell proliferation and renal tubular regeneration., [RefSeq, PubMed]; This study demonistrated that the ags3 expression increassing in rat brain cortex after traumatic brain injury., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K3E2", "ec_number_list": [], "go_molecular_function": "GO:0001965 G-protein alpha-subunit binding;GO:0005092 GDP-dissociation inhibitor activity;GO:0030695 GTPase regulator activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005938 cell cortex", "go_biological_process": "GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0016239 positive regulation of macroautophagy;GO:0034260 negative regulation of GTPase activity;GO:0000132 establishment of mitotic spindle orientation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9R080-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q920R4-1", "uniprot_id": [ { "id": "GASP1_RAT", "url": "https://www.uniprot.org/uniprot/Q920R4", "type": "external" } ], "mass": 151349.0, "length": 1346, "protein_name": "G protein-coupled receptor-associated sorting protein 1", "gene_name": "Gprasp1", "organism": "Rat", "refseq_name": "G-protein coupled receptor-associated sorting protein 1", "refseq_ac": [ { "id": "NP_599213", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599213", "type": "external" } ], "gene_names_uniprotkb": "Gprasp1; Pips", "gene_names_refseq": "Gprasp1; pips", "protein_names_uniprotkb": "G protein-coupled receptor-associated sorting protein 1; GASP-1; Per1-interacting protein", "protein_names_refseq": "G-protein coupled receptor-associated sorting protein 1; GASP-1; Per1 interacting protein; per1-interacting protein", "tax_id": 10116, "disease": "", "pathway": " (rno:171407)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11597585;12176169;12409294;16049099;16298334;22673903", "class_list": "", "function": "Ca(2+)/cAMP response element-binding protein (CREB) and Per1 are integral components of the pathway transducing light-stimulated GLU neurotransmission into phase advance of the circadian clock, [RefSeq, PubMed]; Modulates lysosomal sorting and functional down-regulation of a variety of G protein-coupled receptors. Targets receptors for degradation in lysosomes via its interaction with BECN2 (By similarity)., [UniProtKB, PubMed]; Nuclear translocation of PIPS is involved in NGF mediated neuronal survival via TrkA, PI3K, and Gab1 signaling pathway, [RefSeq, PubMed]; Per1 gene product in the rat suprachiasmatic nucleus is modulated by seasonal changes in daylength., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0008333 endosome to lysosome transport;GO:1990172 G protein-coupled receptor catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q920R4-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04466-1", "uniprot_id": [ { "id": "MYL11_RAT", "url": "https://www.uniprot.org/uniprot/P04466", "type": "external" } ], "mass": 18969.0, "length": 169, "protein_name": "Myosin regulatory light chain 11", "gene_name": "Myl11", "organism": "Rat", "refseq_name": "myosin regulatory light chain 11", "refseq_ac": [ { "id": "NP_036737", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036737", "type": "external" } ], "gene_names_uniprotkb": "Myl11; Mylpf", "gene_names_refseq": "MLC2; Myl11; Myl2; Mylpf; Myolc1", "protein_names_uniprotkb": "Myosin regulatory light chain 11; DTNB; Fast skeletal myosin light chain 2; G2; MLC-2; Myosin light chain 11; Myosin regulatory light chain 2, skeletal muscle isoform", "protein_names_refseq": "DTNB; G2; MLC-2; Myosin, light polypeptide 2, alkali; fast skeletal myosin light chain 2; myosin light chain, phosphorylatable, fast skeletal muscle; myosin regulatory light chain 11; ventricular, skeletal, slow", "tax_id": 10116, "disease": "hypertrophic cardiomyopathy 10 (Disease Ontology:DOID:0110316); distal arthrogryposis type 1A (Disease Ontology:DOID:0111597); distal arthrogryposis type 1C (Disease Ontology:DOID:0112190)", "pathway": " (rno:24584); (R-RNO-445355)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "14561531;22673903;6091059;6179945", "class_list": "", "function": "Myosin regulatory subunit that plays an essential to maintain muscle integrity during early development (By similarity). Plays a role in muscle contraction (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Results demonstrate that the -270MLC2s promoter contains the elements necessary for expression of MLC2s in regenerating overloaded plantaris muscle, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0008307 structural constituent of muscle", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016459 myosin complex", "go_biological_process": "GO:0006936 muscle contraction;GO:0006955 immune response;GO:0007519 skeletal muscle tissue development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P04466-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15865-1", "uniprot_id": [ { "id": "H14_RAT", "url": "https://www.uniprot.org/uniprot/P15865", "type": "external" } ], "mass": 21987.0, "length": 219, "protein_name": "Histone H1.4", "gene_name": "H1-4", "organism": "Rat", "refseq_name": "histone H1.4", "refseq_ac": [ { "id": "NP_579819", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_579819", "type": "external" } ], "gene_names_uniprotkb": "H1-4; H1f4", "gene_names_refseq": "H1-4; H14; H1d; H1f4; Hist1h1c; Hist1h1d; Hist1h1e", "protein_names_uniprotkb": "Histone H1.4; H1d", "protein_names_refseq": "H1 histone family, member 4; Histone 1d; histone H1.2; histone H1.4; histone cluster 1 H1 family member e; histone cluster 1, H1d; histone cluster 1, H1e", "tax_id": 10116, "disease": "", "pathway": " (rno:201097); (R-RNO-140342); (R-RNO-2559584)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "20888776;22673903;2373370;38843836;8003976;8439560", "class_list": "", "function": "Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers and promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex. Ability to associate with nucleosomes and compact chromatin depends on linker DNA length and trajectory. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation., [UniProtKB, UniProtKB]; The data presented herein regarding chromatin remodeling indirectly support the hypothesis that LOX binds to histone H1 in vivo., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0032564 dATP binding;GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0000166 nucleotide binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0000785 chromatin;GO:0000791 euchromatin;GO:0000792 heterochromatin", "go_biological_process": "GO:0006334 nucleosome assembly;GO:0030261 chromosome condensation;GO:0045910 negative regulation of DNA recombination", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P15865-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18506-1", "uniprot_id": [ { "id": "GBRD_RAT", "url": "https://www.uniprot.org/uniprot/P18506", "type": "external" } ], "mass": 50566.0, "length": 449, "protein_name": "Gamma-aminobutyric acid receptor subunit delta", "gene_name": "Gabrd", "organism": "Rat", "refseq_name": "gamma-aminobutyric acid receptor subunit delta precursor", "refseq_ac": [ { "id": "NP_058985", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058985", "type": "external" } ], "gene_names_uniprotkb": "Gabrd", "gene_names_refseq": "GABAA-RD; Gabrd", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit delta; GABA(A) receptor subunit delta; GABAAR subunit delta", "protein_names_refseq": "GABA(A) receptor subunit delta; GABA-A receptor delta-subunit; GABAA receptor delta subunit; GABAAR subunit delta; gamma-aminobutyric acid (GABA) A receptor, delta; gamma-aminobutyric acid (GABA-A) receptor, subunit delta; gamma-aminobutyric acid A receptor, delta; gamma-aminobutyric acid receptor subunit delta precursor; gamma-aminobutyric acid receptor subunit delta; gamma-aminobutyric acid type A receptor delta subunit", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); epilepsy (Disease Ontology:DOID:1826); postpartum depression (Disease Ontology:DOID:9478); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (rno:29689)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "1690000;17003036;22673903;2561970;32803504;34202516;8195163;9464994", "class_list": "", "function": "Ameliorative effect of curcumin on altered expression of CACNA1A and GABRD in the pathogenesis of FeCl3-induced epilepsy., [RefSeq, PubMed]; Delta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (By similarity). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). GABAARs containing delta/GABRD subunits are predominantly expressed and located in extrasynaptic or perisynaptic positions on hippocampus and cerebellar granule cells, and contribute to the tonic GABAergic inhibition (PubMed:9464994). GABAAR containing alpha-4-beta-3-delta subunits can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation of sleep and wakefulness (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; The Dual Role of the GABAA Receptor in Peripheral Inflammation and Neuroinflammation: A Study in Hyperammonemic Rats. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0005254 chloride channel activity;GO:0004890 GABA-A receptor activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0005230 extracellular ligand-gated monoatomic ion channel activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0007214 gamma-aminobutyric acid signaling pathway;GO:0007268 chemical synaptic transmission;GO:1902476 chloride transmembrane transport;GO:0051932 synaptic transmission, GABAergic;GO:0007267 cell-cell signaling", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P18506-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21708-1", "uniprot_id": [ { "id": "MK03_RAT", "url": "https://www.uniprot.org/uniprot/P21708", "type": "external" } ], "mass": 43081.0, "length": 380, "protein_name": "Mitogen-activated protein kinase 3", "gene_name": "Mapk3", "organism": "Rat", "refseq_name": "mitogen-activated protein kinase 3", "refseq_ac": [ { "id": "NP_059043", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059043", "type": "external" } ], "gene_names_uniprotkb": "Mapk3; Erk1; Prkm3", "gene_names_refseq": "ERK1; ERT2; Erk-1; Esrk1; MAPK1; MNK1; Mapk3; Prkm3; p44erk1; p44mapk; p44", "protein_names_uniprotkb": "Mitogen-activated protein kinase 3; 2.7.11.24; ERK-1; ERT2; Extracellular signal-regulated kinase 1; Insulin-stimulated MAP2 kinase; MAP kinase 3; MAP kinase isoform p44; MAPK 3; MNK1; Microtubule-associated protein 2 kinase; p44-ERK1; p44-MAPK", "protein_names_refseq": "MAP kinase 1; MAP kinase 3; MAPK 1; MAPK 3; extracellular signal-regulated kinase 1; insulin-stimulated MAP2 kinase; microtubule-associated protein 2 kinase; mitogen-activated 3; mitogen-activated protein kinase 1; mitogen-activated protein kinase 3", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); withdrawal disorder (Disease Ontology:DOID:0060001); chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515); developmental and epileptic encephalopathy 55 (Disease Ontology:DOID:0080283); gastric ulcer (Disease Ontology:DOID:10808); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); cancer (Disease Ontology:DOID:162); colon adenocarcinoma (Disease Ontology:DOID:234); morphine dependence (Disease Ontology:DOID:2560); endometrial adenocarcinoma (Disease Ontology:DOID:2870); endometrial carcinoma (Disease Ontology:DOID:2871); middle cerebral artery infarction (Disease Ontology:DOID:3525); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); ureteral obstruction (Disease Ontology:DOID:5199); schizophrenia (Disease Ontology:DOID:5419); pulmonary hypertension (Disease Ontology:DOID:6432); cocaine abuse (Disease Ontology:DOID:809); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (rno:50689); (R-RNO-110056); (R-RNO-112409); (R-RNO-1169408); (R-RNO-1181150); (R-RNO-1295596); (R-RNO-1502540); (R-RNO-162658); (R-RNO-170968); (R-RNO-198753); (R-RNO-202670); (R-RNO-2029482); (R-RNO-2173795); (R-RNO-2173796); (R-RNO-2559580); (R-RNO-2559582); (R-RNO-2559585); (R-RNO-2871796); (R-RNO-3371453); (R-RNO-375165); (R-RNO-445144); (R-RNO-450341); (R-RNO-456926); (R-RNO-5654726); (R-RNO-5654727); (R-RNO-5654732); (R-RNO-5654733); (R-RNO-5663213); (R-RNO-5668599); (R-RNO-5673001); (R-RNO-5674135); (R-RNO-5674499); (R-RNO-5675221); (R-RNO-6811558); (R-RNO-73728); (R-RNO-74749); (R-RNO-877300); (R-RNO-881907); (R-RNO-8939211); (R-RNO-9627069); (R-RNO-9732724); (R-RNO-982772); (R-RNO-9856649)", "pathway_count": 43, "publication_count": 23, "publication_id_list": "10748187;1327976;15923189;16393692;16641100;1712480;1716439;1846291;18683930;19319189;19565474;2164259;21779493;22673903;23312093;24567387;29959233;36642184;36890454;37338759;38791516;39285628;7939721", "class_list": "", "function": "Cyclic tensile force modifies calvarial osteoblast function via the interplay between ERK1/2 and STAT3. Publication Status: Online-Only, [RefSeq, PubMed]; ERK1/2 Regulates Epileptic Seizures by Modulating the DRP1-Mediated Mitochondrial Dynamic., [RefSeq, PubMed]; Inhibition of ERK1/2 or CRMP2 Disrupts Alcohol Memory Reconsolidation and Prevents Relapse in Rats. Publication Status: Online-Only, [RefSeq, PubMed]; Role of PI3K, ERK1/2, and JAK2 Kinases in the Cardioprotective Effect of Deltorphin II during Cardiac Reperfusion., [RefSeq, PubMed]; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade also plays a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, DEPTOR, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. Phosphorylates GJA1 at 'Ser-279' and 'Ser-282' resulting in an increase in GJA1 ubiquitination and ultimately lysosomal degradation (PubMed:29959233)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 22, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4PIY8;Q62686;Q9JJ13", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "6.1.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.15", "type": "external" }, { "id": "6.1.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.17", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "6.1.1.10", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.10", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "6.3.2.n3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.n3", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "6.1.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.19", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.7.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.-", "type": "external" }, { "id": "6.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.6", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "6.1.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.18", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "3.4.22.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.62", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" } ], "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0072584 caveolin-mediated endocytosis;GO:2000641 regulation of early endosome to late endosome transport;GO:0030878 thyroid gland development;GO:0070498 interleukin-1-mediated signaling pathway;GO:0006468 protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P21708-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P60517-1", "uniprot_id": [ { "id": "GBRAP_RAT", "url": "https://www.uniprot.org/uniprot/P60517", "type": "external" } ], "mass": 13918.0, "length": 117, "protein_name": "Gamma-aminobutyric acid receptor-associated protein", "gene_name": "Gabarap", "organism": "Rat", "refseq_name": "gamma-aminobutyric acid receptor-associated protein", "refseq_ac": [ { "id": "NP_742033", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742033", "type": "external" } ], "gene_names_uniprotkb": "Gabarap", "gene_names_refseq": "Gabarap", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor-associated protein; GABA(A) receptor-associated protein", "protein_names_refseq": "GABA(A) receptor-associated protein; gamma-aminobutyric acid receptor-associated protein", "tax_id": 10116, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888)", "pathway": " (rno:58974); (R-RNO-1632852); (R-RNO-8854214)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10899939;10900017;11461150;11818336;24240096;25172774;25684710", "class_list": "", "function": "Macroautophagic sequestration does not require the LC3 subfamily but the GABARAP subfamily is essential., [RefSeq, PubMed]; These results support the regulatory role of Bcl-2 in autophagy and define GABARAP as a novel interaction partner involved in this intricate connection., [RefSeq, PubMed]; Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton (PubMed:11461150). Involved in autophagy: while LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity). Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (By similarity). Also required for the local activation of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex, regulating ubiquitination a nd degradation of TIAM1, a guanyl-nucleotide exchange factor (GEF) that activates RAC1 and downstream signal transduction. Thereby, regulates different biological processes including the organization of the cytoskeleton, cell migration and proliferation (By similarity). Involved in apoptosis (By similarity). Participates in selective ER-phagy through interaction with UBAC2, promoting recruitment of UBAC2-associated ER fragments to autophagosomes (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9QUI7", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0031625 ubiquitin protein ligase binding;GO:0008429 phosphatidylethanolamine binding;GO:0048487 beta-tubulin binding;GO:0050811 GABA receptor binding", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0000139 Golgi membrane;GO:0000421 autophagosome membrane;GO:0005790 smooth endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0000045 autophagosome assembly;GO:0015031 protein transport;GO:0000226 microtubule cytoskeleton organization;GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P60517-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63138-1", "uniprot_id": [ { "id": "GBRB2_RAT", "url": "https://www.uniprot.org/uniprot/P63138", "type": "external" } ], "mass": 54633.0, "length": 474, "protein_name": "Gamma-aminobutyric acid receptor subunit beta-2", "gene_name": "Gabrb2", "organism": "Rat", "refseq_name": "gamma-aminobutyric acid receptor subunit beta-2 precursor", "refseq_ac": [ { "id": "NP_037089", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037089", "type": "external" } ], "gene_names_uniprotkb": "Gabrb2; Gabrb-2", "gene_names_refseq": "GARB2; Gabrb2", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit beta-2; GABA(A) receptor subunit beta-2; GABAAR subunit beta-2", "protein_names_refseq": "GABA(A) receptor subunit beta-2; GABAAR subunit beta-2; Gamma-aminobutyric acid receptor beta 2; gamma-aminobutyric acid (GABA) A receptor, beta 2; gamma-aminobutyric acid (GABA-A) receptor, subunit beta 2; gamma-aminobutyric acid receptor subunit beta-2 precursor; gamma-aminobutyric acid receptor subunit beta-2; gamma-aminobutyric acid type A receptor beta 2 subunit", "tax_id": 10116, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); developmental and epileptic encephalopathy 92 (Disease Ontology:DOID:0080471); autistic disorder (Disease Ontology:DOID:12849)", "pathway": " (rno:25451); (R-RNO-977443)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "11528422;1660002;17003036;18281286;25172774;2548852;28279354;29706582;33958479;34214584;38843836;9464994", "class_list": "", "function": "Beta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:1660002, PubMed:2548852). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:1660002). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity). GABAARs containing alpha-1 and beta-2 or -3 subunits exhibit synaptogenic activity; the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation (By similarity). Extrasynaptic beta-2 receptors contribute to the tonic GABAergic inhibition (PubMed:9464994). Beta-containing GABAARs can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation of sleep and wakefulness (PubMed:18281286)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; In inhibitory transmission onto hippocampal CA1 pyramidal cells, deletion of all beta subunits 1, 2, and 3 completely eliminated inhibitory responses. In addition, only knockout of beta3, alone or in combination with another beta subunit, impaired inhibitory synaptic transmission. expression of beta3 alone on the background of the beta1-3 subunit knockout was sufficient to restore synaptic and extrasynaptic inhibitory ..., [RefSeq, PubMed]; Intrasubunit and Intersubunit Steroid Binding Sites Independently and Additively Mediate alpha1beta2gamma2L GABAA Receptor Potentiation by the Endogenous Neurosteroid Allopregnanolone., [RefSeq, PubMed]; The beta2 subunit E155 residue as a proton sensor at the binding site on GABA type A receptors., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "P15432", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0005254 chloride channel activity;GO:0004890 GABA-A receptor activity;GO:0005237 inhibitory extracellular ligand-gated monoatomic ion channel activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0043197 dendritic spine", "go_biological_process": "GO:0042491 inner ear auditory receptor cell differentiation;GO:0060384 innervation;GO:0007214 gamma-aminobutyric acid signaling pathway;GO:1902476 chloride transmembrane transport;GO:0060119 inner ear receptor cell development", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P63138-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08201-1", "uniprot_id": [ { "id": "MDR3_RAT", "url": "https://www.uniprot.org/uniprot/Q08201", "type": "external" } ], "mass": 140655.0, "length": 1278, "protein_name": "Phosphatidylcholine translocator ABCB4", "gene_name": "Abcb4", "organism": "Rat", "refseq_name": "phosphatidylcholine translocator ABCB4", "refseq_ac": [ { "id": "NP_036822", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036822", "type": "external" } ], "gene_names_uniprotkb": "Abcb4; Mdr2; Pgp3; Pgy2", "gene_names_refseq": "Abcb4; Mdr2; Pgy3", "protein_names_uniprotkb": "Phosphatidylcholine translocator ABCB4; 7.6.2.1; ATP-binding cassette sub-family B member 4; Multidrug resistance protein 2; Multidrug resistance protein 3; P-glycoprotein 2; P-glycoprotein 3", "protein_names_refseq": "ATP-binding cassette sub-family B (MDR/TAP) member 4 (P-glycoprotein 3/ multidrug resistance 2); ATP-binding cassette sub-family B member 4; ATP-binding cassette, sub-family B (MDR/TAP), member 4 (P-glycoprotein 3/ multidrug resistance 2); ATP-binding cassette, subfamily B (MDR/TAP), member 4; P-glycoprotein 2; multidrug resistance protein 2; multidrug resistance protein 3; phosphatidylcholine translocator ABCB4", "tax_id": 10116, "disease": "", "pathway": " (rno:24891); (R-RNO-382556)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10067174;1348630;15159385;21454685;7948020;8103593", "class_list": "", "function": "Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi of hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts. Plays a role in the recruitment of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM) molecules to nonraft membranes and to further enrichment of SM and cholesterol in raft membranes in hepatocytes. Required for proper phospholipid bile formation. Indirectly involved in cholesterol efflux activity from hepatocytes into the canalicular lumen in the presence of bile salts in an ATP-dependent manner. May promote biliary phospholipid secretion as canaliculi-containing vesicles from the canalicular plasma membrane. In cooperation with ATP8B1, functions to protect hepatocytes from the deleterious detergent activity of bile salts. Does not confer multidrug resistance., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q78E07", "ec_number_list": [ { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0016887 ATP hydrolysis activity;GO:0090554 phosphatidylcholine floppase activity;GO:0140359 ABC-type transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0055088 lipid homeostasis;GO:0051384 response to glucocorticoid;GO:0045332 phospholipid translocation;GO:0009410 response to xenobiotic stimulus;GO:0061092 positive regulation of phospholipid translocation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q08201-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FVM6-1", "uniprot_id": [ { "id": "MTMRC_RAT", "url": "https://www.uniprot.org/uniprot/Q5FVM6", "type": "external" } ], "mass": 85686.0, "length": 748, "protein_name": "Myotubularin-related protein 12", "gene_name": "Mtmr12", "organism": "Rat", "refseq_name": "myotubularin-related protein 12 isoform 2", "refseq_ac": [ { "id": "NP_001012077", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012077", "type": "external" } ], "gene_names_uniprotkb": "Mtmr12; Pip3ap", "gene_names_refseq": "Mtmr12; Pip3ap", "protein_names_uniprotkb": "Myotubularin-related protein 12; Inactive phosphatidylinositol 3-phosphatase 12; Phosphatidylinositol 3-phosphatase-associated protein", "protein_names_refseq": "inactive phosphatidylinositol 3-phosphatase 12; myotubularin-related protein 12 isoform 2; phosphatidylinositol 3-phosphatase-associated protein", "tax_id": 10116, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (rno:310155); (R-RNO-1660516)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Acts as an adapter for the myotubularin-related phosphatases. Regulates phosphatase MTM1 protein stability and possibly its intracellular location. By stabilizing MTM1 protein levels, required for skeletal muscle maintenance but not for myogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0030017 sarcomere;GO:0016529 sarcoplasmic reticulum", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5FVM6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PPP4-1", "uniprot_id": [ { "id": "MAGH1_RAT", "url": "https://www.uniprot.org/uniprot/Q5PPP4", "type": "external" } ], "mass": 24289.0, "length": 218, "protein_name": "Melanoma-associated antigen H1", "gene_name": "Mageh1", "organism": "Rat", "refseq_name": "melanoma-associated antigen H1", "refseq_ac": [ { "id": "NP_001013268", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013268", "type": "external" } ], "gene_names_uniprotkb": "Mageh1", "gene_names_refseq": "Mageh1", "protein_names_uniprotkb": "Melanoma-associated antigen H1; MAGE-H1 antigen", "protein_names_refseq": "MAGE-H1 antigen; melanoma antigen, family H, 1; melanoma-associated antigen H1", "tax_id": 10116, "disease": "", "pathway": " (rno:367767)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12414813;16641100", "class_list": "", "function": "Necdin and MAGE-H1 are interactors for the intracellular domain of p75., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0048011 neurotrophin TRK receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5PPP4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PQM4-1", "uniprot_id": [ { "id": "MBPHL_RAT", "url": "https://www.uniprot.org/uniprot/Q5PQM4", "type": "external" } ], "mass": 38924.0, "length": 355, "protein_name": "Myosin-binding protein H-like", "gene_name": "Mybphl", "organism": "Rat", "refseq_name": "myosin-binding protein H-like", "refseq_ac": [ { "id": "NP_001014064", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014064", "type": "external" } ], "gene_names_uniprotkb": "Mybphl", "gene_names_refseq": "Mybphl; RGD1310511", "protein_names_uniprotkb": "Myosin-binding protein H-like", "protein_names_refseq": "myosin-binding protein H-like", "tax_id": 10116, "disease": "congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (rno:310782)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Myosin-binding protein which plays a role in cardiac function. Seems to regulate conduction in the atria and ventricular conduction systems., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0030017 sarcomere;GO:0036379 myofilament", "go_biological_process": "GO:0001701 in utero embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5PQM4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U2U7-1", "uniprot_id": [ { "id": "MCES_RAT", "url": "https://www.uniprot.org/uniprot/Q5U2U7", "type": "external" } ], "mass": 52817.0, "length": 461, "protein_name": "mRNA cap guanine-N(7) methyltransferase", "gene_name": "Rnmt", "organism": "Rat", "refseq_name": "mRNA cap guanine-N(7) methyltransferase", "refseq_ac": [ { "id": "NP_001008300", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008300", "type": "external" } ], "gene_names_uniprotkb": "Rnmt", "gene_names_refseq": "Rnmt", "protein_names_uniprotkb": "mRNA cap guanine-N(7) methyltransferase; 2.1.1.56; RG7MT1; mRNA (guanine-N(7))-methyltransferase; mRNA cap methyltransferase", "protein_names_refseq": "RG7MT1; mRNA (guanine-N(7)-)-methyltransferase; mRNA cap guanine-N(7) methyltransferase; mRNA cap guanine-N7 methyltransferase; mRNA cap methyltransferase", "tax_id": 10116, "disease": "", "pathway": " (rno:291534); (R-RNO-72086); (R-RNO-77075)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.1.1.56", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.56", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0043235 receptor complex;GO:0001650 fibrillar center;GO:0031533 mRNA capping enzyme complex", "go_biological_process": "GO:1990830 cellular response to leukemia inhibitory factor;GO:0006370 7-methylguanosine mRNA capping", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5U2U7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63538-1", "uniprot_id": [ { "id": "MK12_RAT", "url": "https://www.uniprot.org/uniprot/Q63538", "type": "external" } ], "mass": 41985.0, "length": 367, "protein_name": "Mitogen-activated protein kinase 12", "gene_name": "Mapk12", "organism": "Rat", "refseq_name": "mitogen-activated protein kinase 12", "refseq_ac": [ { "id": "NP_068514", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068514", "type": "external" } ], "gene_names_uniprotkb": "Mapk12; Sapk3", "gene_names_refseq": "Mapk12; Sapk3", "protein_names_uniprotkb": "Mitogen-activated protein kinase 12; 2.7.11.24; ERK-6; Extracellular signal-regulated kinase 6; MAP kinase 12; MAP kinase p38 gamma; MAPK 12; Mitogen-activated protein kinase p38 gamma; Stress-activated protein kinase 3", "protein_names_refseq": "ERK-6; MAP kinase 12; MAP kinase p38 gamma; MAPK 12; SAP kinase-3; extracellular signal-regulated kinase 6; mitogen-activated protein kinase 12; mitogen-activated protein kinase p38 gamma; stress-activated protein kinase 3", "tax_id": 10116, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (rno:60352); (R-RNO-168638); (R-RNO-4420097); (R-RNO-525793); (R-RNO-5675221)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "10438538;11991731;15158451;15878399;19135240;20626350;22673903;27574735;34814904;8925912", "class_list": "", "function": "SAPK3 activity towards PDZ domain-containing substrates such as alpha1-Syntrophin is inhibited by outer membrane protein 25., [RefSeq, PubMed]; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation. Phosphorylates DLG1. Following osmotic shock, MAPK12 in the cell nucleus increases its association with nuclear DLG1, thereby causing dissociation of DLG1-SFPQ complexes. This function is independent of its catalytic activity and could affect mRNA processing and/or gene transcription to aid cell adaptation to osmolarity changes in the environment. Regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage and G2 arrest after gamma-radiation exposure. MAPK12 is involved in the regulation of SLC2A1 expression and basal glucose uptake in L6 myotubes; and negatively regulates SLC2A4 expression and contraction-mediated glucose uptake in adult skeletal muscle. C-Jun (JUN) phosphorylation is stimulated by MAPK14 and inhibited by MAPK12, leading to a distinct AP-1 regulation. MAPK12 is required for the normal kinetochore localization of PLK1, prevents chromosomal instability and supports mitotic cell viability. MAPK12-signaling is also positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration., [UniProtKB, PubMed, PubMed]; The role of MAPK11/12/13/14 (p38 MAPK) protein in dopamine agonist-resistant prolactinomas. Publication Status: Online-Only, [RefSeq, PubMed]; These results demonstrated that Exenatide improved cardiac function, increased translocation of GLUTs, and suppressed translocation of FAT/CD36 after myocardial I/R injury. This protective effect was mediated, at least in part, through modulation of the cardiac p38gamma MAPK., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004707 MAP kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006468 protein phosphorylation;GO:0035556 intracellular signal transduction;GO:0000165 MAPK cascade;GO:0045786 negative regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q63538-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66HF9-1", "uniprot_id": [ { "id": "LRRF1_RAT", "url": "https://www.uniprot.org/uniprot/Q66HF9", "type": "external" } ], "mass": 80019.0, "length": 738, "protein_name": "Leucine-rich repeat flightless-interacting protein 1", "gene_name": "Lrrfip1", "organism": "Rat", "refseq_name": "leucine-rich repeat flightless-interacting protein 1 isoform 2", "refseq_ac": [ { "id": "NP_001014291", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014291", "type": "external" } ], "gene_names_uniprotkb": "Lrrfip1", "gene_names_refseq": "Lrrfip1", "protein_names_uniprotkb": "Leucine-rich repeat flightless-interacting protein 1; LRR FLII-interacting protein 1", "protein_names_refseq": "LRR FLII-interacting protein 1; leucine rich repeat (in FLII) interacting protein 1; leucine-rich repeat flightless-interacting protein 1 isoform 2; leucine-rich repeat flightless-interacting protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:367314)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10364563;22673903;23880186;24637094;25532521;28322931", "class_list": "", "function": "First report to identify the different transcriptional variants of Lrrfip1 in the brain and to characterize their differential expression patterns and the subcellular location of the main isoform rLrrfip1 in ischemic conditions, [RefSeq, PubMed]; LRRFIP1-Iso1 is a muscle and cardiomyocyte specific Wnt transcription co-factor., [RefSeq, PubMed]; Our results suggest that miR-132 is a novel regulator of vascular smooth muscle cells proliferation that represses neointimal formation by inhibiting LRRFIP1 expression., [RefSeq, PubMed]; Results identify LRRFIP1, SMARCA4, and DNMT1 as novel regulators of macrophage multinucleation., [RefSeq, PubMed]; Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0042803 protein homodimerization activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q66HF9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXS3-1", "uniprot_id": [ { "id": "DEK_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXS3", "type": "external" } ], "mass": 42892.0, "length": 378, "protein_name": "Protein DEK", "gene_name": "Dek", "organism": "Rat", "refseq_name": "protein DEK", "refseq_ac": [ { "id": "NP_001004255", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004255", "type": "external" } ], "gene_names_uniprotkb": "Dek", "gene_names_refseq": "Dek", "protein_names_uniprotkb": "Protein DEK", "protein_names_refseq": "DEK oncogene (DNA binding); protein DEK", "tax_id": 10116, "disease": "", "pathway": " (rno:306817); (R-RNO-5250924); (R-RNO-8864260)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Involved in chromatin organization., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 28, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0043292 contractile muscle fiber;GO:0110016 B-WICH complex", "go_biological_process": "GO:0006325 chromatin organization;GO:0045945 positive regulation of transcription by RNA polymerase III;GO:2000779 regulation of double-strand break repair;GO:2001032 regulation of double-strand break repair via nonhomologous end joining", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AXS3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WVE9-3", "uniprot_id": [ { "id": "ITSN1_RAT", "url": "https://www.uniprot.org/uniprot/Q9WVE9", "type": "external" } ], "mass": 194197.0, "length": 1713, "protein_name": "Intersectin-1", "gene_name": "Itsn1", "organism": "Rat", "refseq_name": "intersectin-1 isoform a", "refseq_ac": [ { "id": "NP_001129568", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129568", "type": "external" } ], "gene_names_uniprotkb": "Itsn1; Ehsh1; Itsn", "gene_names_refseq": "EHSH1; Itsn1; Itsn", "protein_names_uniprotkb": "Intersectin-1; EH domain and SH3 domain regulator of endocytosis 1", "protein_names_refseq": "EH domain and SH3 domain regulator of endocytosis 1; intersectin 1 (SH3 domain protein 1A); intersectin 1 (SH3 domain protein); intersectin-1 isoform a; intersectin-1-like", "tax_id": 10116, "disease": "intellectual disability (Disease Ontology:DOID:1059); azoospermia (Disease Ontology:DOID:14227)", "pathway": " (rno:29491); (R-RNO-193648); (R-RNO-3928662); (R-RNO-416482); (R-RNO-8856825); (R-RNO-8856828); (R-RNO-9013148); (R-RNO-9013406); (R-RNO-9013408)", "pathway_count": 9, "publication_count": 9, "publication_id_list": "10373452;11584276;16394100;20448150;22673903;23633571;26797119;29393594;36307995", "class_list": "", "function": "Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery. Acts as a guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex (By similarity). Plays a role in the assembly and maturation of clathrin-coated vesicles (PubMed:20448150). Recruits FCHSD2 to clathrin-coated pits (By similarity). Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2 (By similarity). Promotes ubiquitination and subsequent degradation of EGFR, and thereby contributes to the down-regulation of EGFR-dependent signaling pathways. In chromaffin cells, required for normal exocytosis of catecholamines (By similarity). Required for rapid replenishment of release-ready synaptic vesicles at presynaptic active zones (PubMed:23633571). Inhibits ARHGAP31 activity toward RAC1 (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Expression levels of NPPB, ITGB6, CPNE4, EML5, and ITSN1 in fresh exudates swabbed from critically colonised and infected full-thickness wounds in rats., [RefSeq, PubMed]; Plays a role in synaptic vesicle endocytosis in brain neurons., [UniProtKB, UniProtKB]; These results highlight a role of Numb for dendritic spine development and synaptic functions with intersectin and EphB2., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3ZV52;F1M823;Q9WVE1", "ec_number_list": [], "go_molecular_function": "GO:0019209 kinase activator activity;GO:0060090 molecular adaptor activity;GO:0030674 protein-macromolecule adaptor activity;GO:0005509 calcium ion binding;GO:0070064 proline-rich region binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0044305 calyx of Held;GO:0098871 postsynaptic actin cytoskeleton;GO:0097708 intracellular vesicle;GO:0005635 nuclear envelope", "go_biological_process": "GO:2001288 positive regulation of caveolin-mediated endocytosis;GO:0006897 endocytosis;GO:0007267 cell-cell signaling;GO:0015031 protein transport;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9WVE9-3", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07266-1", "uniprot_id": [ { "id": "DREB_RAT", "url": "https://www.uniprot.org/uniprot/Q07266", "type": "external" } ], "mass": 77472.0, "length": 707, "protein_name": "Drebrin", "gene_name": "Dbn1", "organism": "Rat", "refseq_name": "drebrin", "refseq_ac": [ { "id": "NP_112286", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112286", "type": "external" } ], "gene_names_uniprotkb": "Dbn1", "gene_names_refseq": "Dbn1", "protein_names_uniprotkb": "Drebrin; Developmentally-regulated brain protein", "protein_names_refseq": "developmentally-regulated brain protein; drebrin E; drebrin", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); sciatic neuropathy (Disease Ontology:DOID:11446); Down syndrome (Disease Ontology:DOID:14250); Parkinson's disease (Disease Ontology:DOID:14330); cognitive disorder (Disease Ontology:DOID:1561); transient cerebral ischemia (Disease Ontology:DOID:224); temporal lobe epilepsy (Disease Ontology:DOID:3328)", "pathway": " (rno:81653)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "1611026;22673903;28865017;28865027;34478582", "class_list": "", "function": "Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections (By similarity). Required for actin polymerization at immunological synapses (IS) and for the recruitment of the chemokine receptor CXCR4 to IS (By similarity). Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines (By similarity). Involved in memory-related synaptic plasticity in the hippocampus (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections. Required for actin polymerization at immunological synapses (IS) and for the recruitment of the chemokine receptor CXCR4 to IS. Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines. Involved in memory-related synaptic plasticity in the hippocampus., [UniProtKB, UniProtKB]; In the adult brain, drebrin is mainly localized in dendritic spines, but in some nuclei, drebrin can be detected in neuronal somata as well as dendritic spines. The fact that the developmental changes in drebrin expression highly correlate in time with the sensitive period of visual cortical plasticity in kittens suggests that synaptic plasticity depends on drebrin. Review article, [RefSeq, PubMed]; The drebrin/EB3 pathway regulates cytoskeletal dynamics to drive neuritogenesis in embryonic cortical neurons., [RefSeq, PubMed]; These data are carefully evaluated in light of other recent findings herein regarding the role of drebrin in actin filament organization at the ES., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A5D6R1;O70205", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0008092 cytoskeletal protein binding;GO:0005522 profilin binding;GO:0140311 protein sequestering activity;GO:0140661 cytoskeletal motor inhibitor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098871 postsynaptic actin cytoskeleton;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005884 actin filament", "go_biological_process": "GO:0032507 maintenance of protein location in cell;GO:0098828 modulation of inhibitory postsynaptic potential;GO:1904113 negative regulation of muscle filament sliding;GO:0001701 in utero embryonic development;GO:0007015 actin filament organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q07266-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19332-1", "uniprot_id": [ { "id": "TAU_RAT", "url": "https://www.uniprot.org/uniprot/P19332", "type": "external" } ], "mass": 78564.0, "length": 752, "protein_name": "Microtubule-associated protein tau", "gene_name": "Mapt", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mapt; Mtapt; Tau", "gene_names_refseq": "", "protein_names_uniprotkb": "Microtubule-associated protein tau; Neurofibrillary tangle protein; PHF-tau; Paired helical filament-tau", "protein_names_refseq": "", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); frontotemporal dementia 1 (Disease Ontology:DOID:0051060); late onset Parkinson's disease (Disease Ontology:DOID:0060892); Parkinsonism (Disease Ontology:DOID:0080855); traumatic brain injury (Disease Ontology:DOID:0081292); Alzheimer's disease (Disease Ontology:DOID:10652); amnestic disorder (Disease Ontology:DOID:10914); Pick's disease (Disease Ontology:DOID:11870); Creutzfeldt-Jakob disease (Disease Ontology:DOID:11949); neurodegenerative disease (Disease Ontology:DOID:1289); dementia (Disease Ontology:DOID:1307); Parkinson's disease (Disease Ontology:DOID:14330); cognitive disorder (Disease Ontology:DOID:1561); breast cancer (Disease Ontology:DOID:1612); epilepsy (Disease Ontology:DOID:1826); brain ischemia (Disease Ontology:DOID:2316); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); temporal lobe epilepsy (Disease Ontology:DOID:3328); middle cerebral artery infarction (Disease Ontology:DOID:3525); progressive supranuclear palsy (Disease Ontology:DOID:678); tauopathy (Disease Ontology:DOID:680); vascular dementia (Disease Ontology:DOID:8725); frontotemporal dementia (Disease Ontology:DOID:9255); obesity (Disease Ontology:DOID:9970)", "pathway": " (R-RNO-264870); (R-RNO-9833482)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "1542696;19692427;20133804;20706749;22673903;2504728;2560640;30386294;7877441;7964751;8057376;8245007;8408300", "class_list": "", "function": "Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 45, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 24, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "Q63567;Q63677;Q9QW06", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0004857 enzyme inhibitor activity;GO:0008017 microtubule binding;GO:0017124 SH3 domain binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule", "go_biological_process": "GO:0031110 regulation of microtubule polymerization or depolymerization;GO:0032387 negative regulation of intracellular transport;GO:0046785 microtubule polymerization;GO:0047497 mitochondrion transport along microtubule;GO:1903748 negative regulation of establishment of protein localization to mitochondrion", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P19332-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29994-1", "uniprot_id": [ { "id": "ITPR1_RAT", "url": "https://www.uniprot.org/uniprot/P29994", "type": "external" } ], "mass": 313264.0, "length": 2750, "protein_name": "Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1", "gene_name": "Itpr1", "organism": "Rat", "refseq_name": "inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 isoform 3", "refseq_ac": [ { "id": "NP_001257526", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257526", "type": "external" } ], "gene_names_uniprotkb": "Itpr1; Insp3r", "gene_names_refseq": "I145TR; IP3R1; InsP3R1; InsP3R; Itpr1; P400", "protein_names_uniprotkb": "Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1; IP-3-R; IP3 receptor isoform 1; IP3R 1; Inositol 1,4,5-trisphosphate receptor type 1; Inositol 1,4,5-trisphosphate receptor; InsP3R1; Type 1 InsP3 receptor; Type 1 inositol 1,4,5-trisphosphate receptor", "protein_names_refseq": "IP-3-R; IP3 receptor; IP3R 1; inositol 1,4,5-triphosphate receptor 1; inositol 1,4,5-triphosphate receptor, type 1; inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 isoform 3; inositol 1,4,5-trisphosphate-gated calcium channel ITPR1; type 1 InsP3 receptor; type 1 inositol 1,4,5-trisphosphate receptor", "tax_id": 10116, "disease": "spinocerebellar ataxia 15 (Disease Ontology:DOID:0050965); spinocerebellar ataxia 29 (Disease Ontology:DOID:0050978); cardiac arrest (Disease Ontology:DOID:0060319); Gillespie syndrome (Disease Ontology:DOID:0111578); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); gestational diabetes (Disease Ontology:DOID:11714); myotonic dystrophy type 1 (Disease Ontology:DOID:11722); Huntington's disease (Disease Ontology:DOID:12858); autosomal dominant cerebellar ataxia (Disease Ontology:DOID:1441); congenital heart disease (Disease Ontology:DOID:1682); transient cerebral ischemia (Disease Ontology:DOID:224); asthma (Disease Ontology:DOID:2841); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25262); (R-RNO-114508); (R-RNO-139853); (R-RNO-381676); (R-RNO-418457); (R-RNO-5578775); (R-RNO-983695)", "pathway_count": 7, "publication_count": 20, "publication_id_list": "10.1039/D0MO00044B;10506212;11163362;12032348;12939273;17178908;1849282;18535093;18955483;2165071;21892169;22286060;22547632;22673903;34106099;36376291;38308199;38685831;38843836;9073177", "class_list": "", "function": "IP3R1-mediated MAMs formation contributes to mechanical trauma-induced hepatic injury and the protective effect of melatonin. Publication Status: Online-Only, [RefSeq, PubMed]; Inositol 1,4,5-trisphosphate-gated calcium channel that upon inositol 1,4,5-trisphosphate binding transports calcium from the endoplasmic reticulum lumen to cytoplasm. Exists in two states; a long-lived closed state where the channel is essentially 'parked' with only very rare visits to an open state and that ligands facilitate the transition from the 'parked' state into a 'drive' mode represented by periods of bursting activity., [UniProtKB, UniProtKB]; Inositol 1,4,5-trisphosphate-gated calcium channel that, upon inositol 1,4,5-trisphosphate binding, mediates calcium release from the endoplasmic reticulum (ER) (PubMed:2165071, PubMed:22547632, PubMed:36376291). Undergoes conformational changes upon ligand binding, suggesting structural flexibility that allows the channel to switch from a closed state, capable of interacting with its ligands such as 1,4,5-trisphosphate and calcium, to an open state, capable of transferring calcium ions across the ER membrane (PubMed:36376291). Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CAMK2 complex (By similarity). Part of a complex composed of HSPA9, ITPR1 and VDAC1 that regulates mitochondrial calcium-dependent apoptosis by facilitating calcium transport from the ER lumen to the mitochondria intermembrane space thus providing calcium for the downstream calcium channel MCU that directly releases it into mitochondria matrix (By similarity). Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Regulates fertilization and egg activation by tuning the frequency and amplitude of calcium oscillations (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The role of Ca[2+] signalling and InsP3R in the pathogenesis of intrahepatic cholestasis of pregnancy., [RefSeq, PubMed]; This gene belongs to the Insp3 receptor family. It encodes an intracellular receptor for inositol 1,4,5-trisphosphate. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2012]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 14, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q62869", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0070679 inositol 1,4,5 trisphosphate binding;GO:0005220 inositol 1,4,5-trisphosphate-gated calcium channel activity;GO:0005524 ATP binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0031094 platelet dense tubular network;GO:0005635 nuclear envelope;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:2000347 positive regulation of hepatocyte proliferation;GO:0050882 voluntary musculoskeletal movement;GO:0050849 negative regulation of calcium-mediated signaling;GO:0042045 epithelial fluid transport;GO:0007204 positive regulation of cytosolic calcium ion concentration", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P29994-1", "record_type": "protein", "filter_code": "0000000.0100111.001000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A096MJY4-1", "uniprot_id": [ { "id": "MEF2C_RAT", "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "type": "external" } ], "mass": 51217.0, "length": 473, "protein_name": "Myocyte-specific enhancer factor 2C", "gene_name": "Mef2c", "organism": "Rat", "refseq_name": "myocyte-specific enhancer factor 2C isoform 1", "refseq_ac": [ { "id": "NP_001386326", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001386326", "type": "external" } ], "gene_names_uniprotkb": "Mef2c", "gene_names_refseq": "Mef2c; RGD1563119", "protein_names_uniprotkb": "Myocyte-specific enhancer factor 2C; Myocyte enhancer factor 2C", "protein_names_refseq": "myocyte-specific enhancer factor 2C isoform 1; myocyte-specific enhancer factor 2C", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); neurodevelopmental disorder with hypotonia, stereotypic hand movements, and impaired language (Disease Ontology:DOID:0070050); intellectual disability (Disease Ontology:DOID:1059); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); status epilepticus (Disease Ontology:DOID:1824); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (rno:499497); (R-RNO-525793)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "15862299;22673903;25287062;27427476;28473466", "class_list": "", "function": "In cardiomyocytes exposed to biomechanical stimulation, FAK accumulates in the nucleus, binds to and upregulates the transcriptional activity of MEF2c through an interaction with the FAK focal adhesion targeting (FAT) domain., [RefSeq, PubMed]; MEF2A and MEF2D were absolutely required for cardiomyocyte survival, whereas MEF2C, despite its major role in cardiac morphogenesis and direct reprogramming, was dispensable for this process., [RefSeq, PubMed]; Mef2c expression was sharply increased in compensating phase of right ventricular heart failure but lost in decompensation phase., [RefSeq, PubMed]; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes (PubMed:15862299). Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003680 minor groove of adenine-thymine-rich DNA binding;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0098794 postsynapse", "go_biological_process": "GO:0098989 NMDA selective glutamate receptor signaling pathway;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0002931 response to ischemia;GO:0006351 DNA-templated transcription;GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A096MJY4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1M0Z1-1", "uniprot_id": [ { "id": "TRIO_RAT", "url": "https://www.uniprot.org/uniprot/F1M0Z1", "type": "external" } ], "mass": 347860.0, "length": 3100, "protein_name": "Triple functional domain protein", "gene_name": "Trio", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Trio", "gene_names_refseq": "", "protein_names_uniprotkb": "Triple functional domain protein; 2.7.11.1; PTPRF-interacting protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "autosomal dominant intellectual developmental disorder 63 with macrocephaly (Disease Ontology:DOID:0061036); autosomal dominant intellectual developmental disorder 44 (Disease Ontology:DOID:0070074); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (rno:310192); (R-RNO-193648); (R-RNO-416476); (R-RNO-416482); (R-RNO-418885); (R-RNO-8980692); (R-RNO-9013148); (R-RNO-9013149); (R-RNO-9013404); (R-RNO-9013408); (R-RNO-9013409); (R-RNO-9013423)", "pathway_count": 12, "publication_count": 3, "publication_id_list": "22673903;26721934;27907191", "class_list": "", "function": "Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases. Involved in coordinating actin remodeling, which is necessary for cell migration and growth (By similarity). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation (By similarity). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (PubMed:26721934). May act as a regulator of adipogenesis (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0048786 presynaptic active zone;GO:0098794 postsynapse;GO:0042995 cell projection", "go_biological_process": "GO:0048812 neuron projection morphogenesis;GO:0050804 modulation of chemical synaptic transmission;GO:0045599 negative regulation of fat cell differentiation;GO:0007411 axon guidance;GO:0099170 postsynaptic modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "F1M0Z1-1", "record_type": "protein", "filter_code": "0000000.0000111.001000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LQY6-1", "uniprot_id": [ { "id": "NECA2_RAT", "url": "https://www.uniprot.org/uniprot/F1LQY6", "type": "external" } ], "mass": 43526.0, "length": 389, "protein_name": "N-terminal EF-hand calcium-binding protein 2", "gene_name": "Necab2", "organism": "Rat", "refseq_name": "N-terminal EF-hand calcium-binding protein 2", "refseq_ac": [ { "id": "NP_596906", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_596906", "type": "external" } ], "gene_names_uniprotkb": "Necab2; Efcbp2", "gene_names_refseq": "Efcbp2; Necab2", "protein_names_uniprotkb": "N-terminal EF-hand calcium-binding protein 2; EF-hand calcium-binding protein 2; Neuronal calcium-binding protein 2", "protein_names_refseq": "EF hand calcium binding protein 2; N-terminal EF-hand calcium-binding protein 2; neuronal calcium binding 2; neuronal calcium-binding protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:170928)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12044471;17689978;19694902;26843217;32557241", "class_list": "", "function": "May act as a signaling scaffold protein that senses intracellular calcium. Can modulate ligand-induced internalization of ADORA2A and coupling efficiency of mGluR5/GRM5; for both receptors may regulate signaling activity such as promoting MAPK1/3 (ERK1/2) activation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; NECAB2 by its physical interaction with mGlu(5b) receptor modulates receptor function, [RefSeq, PubMed]; TRPV1, Targeted by miR-338-3p, Induces Neuropathic Pain by Interacting with NECAB2., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9ESB4", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0031802 type 5 metabotropic glutamate receptor binding;GO:0005509 calcium ion binding;GO:0031687 A2A adenosine receptor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0098794 postsynapse", "go_biological_process": "GO:0019722 calcium-mediated signaling;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0060168 positive regulation of adenosine receptor signaling pathway;GO:0042984 regulation of amyloid precursor protein biosynthetic process;GO:1900451 positive regulation of glutamate receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "F1LQY6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62940-1", "uniprot_id": [ { "id": "NEDD4_RAT", "url": "https://www.uniprot.org/uniprot/Q62940", "type": "external" } ], "mass": 102395.0, "length": 887, "protein_name": "E3 ubiquitin-protein ligase NEDD4", "gene_name": "Nedd4", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase NEDD4", "refseq_ac": [ { "id": "NP_037118", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037118", "type": "external" } ], "gene_names_uniprotkb": "Nedd4; Nedd4a; Rpf1", "gene_names_refseq": "Nedd4a; Nedd4", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase NEDD4; 2.3.2.26; HECT-type E3 ubiquitin transferase NEDD4", "protein_names_refseq": "E3 ubiquitin-protein ligase NEDD4; HECT-type E3 ubiquitin transferase NEDD4; neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase; neural precursor cell expressed, developmentally down-regulated gene 4A", "tax_id": 10116, "disease": "Liddle syndrome (Disease Ontology:DOID:0050477); tooth agenesis (Disease Ontology:DOID:0050591); ectodermal dysplasia 1 (Disease Ontology:DOID:0111664); hypohidrotic ectodermal dysplasia (Disease Ontology:DOID:14793); carcinoma (Disease Ontology:DOID:305); muscular atrophy (Disease Ontology:DOID:767)", "pathway": " (rno:25489); (R-RNO-1169408); (R-RNO-1253288); (R-RNO-8948747); (R-RNO-8948751); (R-RNO-983168)", "pathway_count": 6, "publication_count": 10, "publication_id_list": "11323714;20159449;22673903;29393594;30826466;35355403;36781297;38418461;38959295;8665844", "class_list": "", "function": "E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates 'Lys-63' in target proteins (By similarity). Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Promotes ubiquitination of RAPGEF2. Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Is involved in ubiquitination of ERBB4 intracellular domain E4ICD (By similarity). Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development (PubMed:20159449). Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2 (By similarity). Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (By similarity). Ubiquitinates DAZAP2, leading to its proteasomal degradation (By similarity). Ubiquitinates POLR2A (By similarity). Functions as a platform to recruit USP13 to form an NEDD4-USP13 deubiquitination complex that plays a critical role in cleaving the 'Lys-48'-linked ubiquitin chains of VPS34 and then stabilizing VPS34, thus promoting the formation of autophagosomes (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Gstp1 negatively regulates blood pressure in hypertensive rat via promoting APLNR ubiquitination degradation mediated by Nedd4., [RefSeq, PubMed]; NEDD4 attenuates phosgene-induced acute lung injury through the inhibition of Notch1 activation., [RefSeq, PubMed]; NEDD4-2 and the CLC-2 channel regulate neuronal excitability in the pathogenesis of mesial temporal lobe epilepsy. Publication Status: Online-Only, [RefSeq, PubMed]; Serum and glucocorticoid inducible kinase 1 modulates mitochondrial dysfunction and oxidative stress in doxorubicin-induced cardiomyocytes by regulating Hippo pathway via Neural precursor cell-expressed developmentally down-regulated 4 type 2., [RefSeq, PubMed]; The data revealed that maternal immune activation impedes offspring's dendrite development and causes depressive like behaviors by upregulating ISG15 and suppressing NEDD4/Rap2A signaling., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" } ], "go_molecular_function": "GO:0019870 potassium channel inhibitor activity;GO:0031698 beta-2 adrenergic receptor binding;GO:0019871 sodium channel inhibitor activity;GO:0019899 enzyme binding;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:1903765 negative regulation of potassium ion export across plasma membrane;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006955 immune response;GO:0007528 neuromuscular junction development;GO:0031175 neuron projection development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q62940-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q811U3-1", "uniprot_id": [ { "id": "RB6I2_RAT", "url": "https://www.uniprot.org/uniprot/Q811U3", "type": "external" } ], "mass": 108818.0, "length": 948, "protein_name": "ELKS/Rab6-interacting/CAST family member 1", "gene_name": "Erc1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Erc1; Cast2; Elks; Rab6ip2", "gene_names_refseq": "", "protein_names_uniprotkb": "ELKS/Rab6-interacting/CAST family member 1; CAST2; CAZ-associated structural protein 2; ERC-1; Rab6-interacting protein 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:266806)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12391317;14723704;16095618;18683930;22673903;30745339;38843836", "class_list": "", "function": "Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex (By similarity). May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 12, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CIY9", "ec_number_list": [], "go_molecular_function": "GO:0098882 structural constituent of presynaptic active zone;GO:0031267 small GTPase binding;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0098831 presynaptic active zone cytoplasmic component;GO:0000139 Golgi membrane;GO:0005737 cytoplasm", "go_biological_process": "GO:0048790 maintenance of presynaptic active zone structure;GO:0015031 protein transport;GO:0006355 regulation of DNA-templated transcription;GO:0042147 retrograde transport, endosome to Golgi;GO:0099509 regulation of presynaptic cytosolic calcium ion concentration", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q811U3-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BK63-1", "uniprot_id": [ { "id": "NDUA9_RAT", "url": "https://www.uniprot.org/uniprot/Q5BK63", "type": "external" } ], "mass": 42559.0, "length": 377, "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial", "gene_name": "Ndufa9", "organism": "Rat", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial", "refseq_ac": [ { "id": "NP_001094222", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094222", "type": "external" } ], "gene_names_uniprotkb": "Ndufa9", "gene_names_refseq": "Ndufa9", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial; CI-39kD; Complex I-39kD; NADH-ubiquinone oxidoreductase 39 kDa subunit; Sperm flagella protein 3", "protein_names_refseq": "CI-39kD; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial; NADH-ubiquinone oxidoreductase 39 kDa subunit; complex I-39kD; sperm flagella protein 3", "tax_id": 10116, "disease": "nuclear type mitochondrial complex I deficiency 26 (Disease Ontology:DOID:0112086)", "pathway": " (rno:362440); (R-RNO-611105); (R-RNO-6799198)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "16396496;19004814;19423663;23132757;26446791;27213235;28100784;29393594;38843836", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 0, "mined_o_glycosites": 1, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "B5DER7", "ec_number_list": [], "go_molecular_function": "GO:0003954 NADH dehydrogenase activity;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0031966 mitochondrial membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0007623 circadian rhythm;GO:0009749 response to glucose;GO:0006744 ubiquinone biosynthetic process;GO:0022904 respiratory electron transport chain", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q5BK63-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100010001000.011.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52591-1", "uniprot_id": [ { "id": "PO121_RAT", "url": "https://www.uniprot.org/uniprot/P52591", "type": "external" } ], "mass": 120785.0, "length": 1199, "protein_name": "Nuclear envelope pore membrane protein POM 121", "gene_name": "Pom121", "organism": "Rat", "refseq_name": "nuclear envelope pore membrane protein POM 121", "refseq_ac": [ { "id": "NP_446074", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446074", "type": "external" } ], "gene_names_uniprotkb": "Pom121; Nup121", "gene_names_refseq": "Pom121", "protein_names_uniprotkb": "Nuclear envelope pore membrane protein POM 121; Nucleoporin Nup121; Pore membrane protein of 121 kDa; p145", "protein_names_refseq": "P145; POM121 membrane glycoprotein; integral membrane glycoprotein; nuclear envelope pore membrane protein POM 121; nuclear pore membrane glycoprotein 121 kD; nuclear pore membrane protein 121; nucleoporin Nup121; pore membrane protein of 121 kDa", "tax_id": 10116, "disease": "", "pathway": " (rno:113975); (R-RNO-159227); (R-RNO-159230); (R-RNO-159231); (R-RNO-159236); (R-RNO-170822); (R-RNO-1855170); (R-RNO-1855196); (R-RNO-1855229); (R-RNO-191859); (R-RNO-3108214); (R-RNO-3232142); (R-RNO-3301854); (R-RNO-3371453); (R-RNO-4085377); (R-RNO-4551638); (R-RNO-4570464); (R-RNO-4615885); (R-RNO-9615933)", "pathway_count": 19, "publication_count": 5, "publication_id_list": "11448991;14729472;21727197;22673903;8335683", "class_list": "", "function": "Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL)., [UniProtKB]; The propose a model in which POM121 and Sun1 interact transiently to promote early steps of interphase nuclear pore complexes assembly., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 0, "predicted_o_glycosites": 6, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017056 structural constituent of nuclear pore;GO:0008139 nuclear localization sequence binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005654 nucleoplasm;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006999 nuclear pore organization;GO:0051028 mRNA transport;GO:0006405 RNA export from nucleus;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P52591-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63120-1", "uniprot_id": [ { "id": "MRP2_RAT", "url": "https://www.uniprot.org/uniprot/Q63120", "type": "external" } ], "mass": 173384.0, "length": 1541, "protein_name": "ATP-binding cassette sub-family C member 2", "gene_name": "Abcc2", "organism": "Rat", "refseq_name": "ATP-binding cassette sub-family C member 2", "refseq_ac": [ { "id": "NP_036965", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036965", "type": "external" } ], "gene_names_uniprotkb": "Abcc2; Cmoat; Cmrp; Mrp2", "gene_names_refseq": "Abcc2; Cmoat; Mrp2; cMRP; mrp", "protein_names_uniprotkb": "ATP-binding cassette sub-family C member 2; 7.6.2.-; 7.6.2.2; 7.6.2.3; Canalicular multidrug resistance protein; Canalicular multispecific organic anion transporter 1; Multidrug resistance-associated protein 2", "protein_names_refseq": "ATP-binding cassette sub-family C member 2; ATP-binding cassette, sub-family C (CFTR/MRP), member 2; ATP-binding cassette, subfamily C (CFTR/MRP), member 2; cMrp2/cMoat canalicular apical conjugate export pump; calicular multispecific organic anion transporter; canalicular multidrug resistance protein; canalicular multispecific organic anion transporter 1; multidrug resistance-associated protein 2", "tax_id": 10116, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); primary biliary cholangitis (Disease Ontology:DOID:12236); Dubin-Johnson syndrome (Disease Ontology:DOID:12308); cholestasis (Disease Ontology:DOID:13580); pancreatic cancer (Disease Ontology:DOID:1793); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); drug-induced hepatitis (Disease Ontology:DOID:2044); bilirubin metabolic disorder (Disease Ontology:DOID:2741); lung non-small cell carcinoma (Disease Ontology:DOID:3908); cholangiocarcinoma (Disease Ontology:DOID:4947); end stage renal disease (Disease Ontology:DOID:783); chronic myeloid leukemia (Disease Ontology:DOID:8552); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:25303); (R-RNO-189483); (R-RNO-382556); (R-RNO-9749641); (R-RNO-9753281); (R-RNO-9754706)", "pathway_count": 6, "publication_count": 12, "publication_id_list": "10220572;10421658;11248200;11306690;22673903;28842383;29052767;30068870;32476256;34303734;8599091;8662992", "class_list": "", "function": "ATP-dependent transporter of the ATP-binding cassette (ABC) family that hydrolyzes ATP to enable active transport of endogenous and xenobiotic substrates conjugated with glucuronate, glutathione or sulfate. Operates at apical membranes of polarized cells such as hepatocytes, renal and intestinal epithelial cells, where it mediates hepatobiliary and renal excretion of conjugated substrates preventing them from being recycled back into the bloodstream (PubMed:10220572, PubMed:10421658, PubMed:11248200, PubMed:8662992). Involved in canalicular bile production. Mediates hepatobiliary excretion of mono- and bis-glucuronidated bilirubin, enabling bilirubin detoxification (PubMed:10421658). Mediates the efflux of steroid glucuronates and may regulate their hepatobiliary and renal metabolic clearance. Displays low affinity but high transport velocity toward androgen conjugates such as testosterone and dihydrotestosterone glucuronates as well as toward estrogen conjugates including estradiol, estrone and estriol glucuronates (By similarity). May control the hepatobiliary and renal efflux of inflammatory leukotriene C4 (LTC4) and related cysteinyl leukotrienes (PubMed:8662992, PubMed:10220572, PubMed:11306690). Transports sulfated bile salt such as taurolithocholate sulfate (PubMed:11248200). It is functionally inactive toward androgen sulfates (By similarity). Transports various anticancer drugs, such as anthracycline, vinca alkaloid and methotrexate and HIV-drugs such as protease inhibitors (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; GLP-2 can prevent down-regulation of intestinal expression and activity of Mrp2 and P-gp in endotoxemic rats., [RefSeq, PubMed]; In conclusion, our data supports the hypothesis that isoniazid can induce liver injury via the down-regulation of hepatic efflux transporters BSEP and MRP2, and the SIRT1/FXR pathway may be the primary regulator with regard to the expression of transporters and the biosynthesis of bile acids in the liver., [RefSeq, PubMed]; Intraluminal nutrients acutely strengthen rat intestinal MRP2 barrier function by a glucagon-like peptide-2-mediated mechanism., [RefSeq, PubMed]; Multidrug resistance-associated protein 2 is negatively regulated by oxidative stress in rat intestine via a posttranslational mechanism. Impact on its membrane barrier function., [RefSeq, PubMed]; We demonstrate redistribution of intestinal MRP2 between plasma membrane and intracellular membrane in rat jejunum and in Caco-2 cells in response to db-cAMP and estradiol-17beta-D-glucuronide, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 13, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q63145", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" } ], "go_molecular_function": "GO:0042910 xenobiotic transmembrane transporter activity;GO:0005524 ATP binding;GO:0019904 protein domain specific binding;GO:0022857 transmembrane transporter activity;GO:0042626 ATPase-coupled transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0016324 apical plasma membrane;GO:0046581 intercellular canaliculus", "go_biological_process": "GO:0016071 mRNA metabolic process;GO:0046685 response to arsenic-containing substance;GO:0030644 intracellular chloride ion homeostasis;GO:0034635 glutathione transport;GO:0006979 response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q63120-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q641Z8-1", "uniprot_id": [ { "id": "PEF1_RAT", "url": "https://www.uniprot.org/uniprot/Q641Z8", "type": "external" } ], "mass": 30012.0, "length": 283, "protein_name": "Peflin", "gene_name": "Pef1", "organism": "Rat", "refseq_name": "peflin", "refseq_ac": [ { "id": "NP_001007652", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007652", "type": "external" } ], "gene_names_uniprotkb": "Pef1", "gene_names_refseq": "Pef1; Peflin", "protein_names_uniprotkb": "Peflin; PEF protein with a long N-terminal hydrophobic domain; Penta-EF hand domain-containing protein 1", "protein_names_refseq": "PEF protein with a long N-terminal hydrophobic domain; peflin; penta-EF hand domain-containing protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:297900)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "27276012;34762908", "class_list": "", "function": "ALG-2 and peflin regulate COPII targeting and secretion in response to calcium signaling., [RefSeq, PubMed]; Calcium-binding protein that acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium. Together with PDCD6, acts as a calcium-dependent adapter for the BCR(KLHL12) complex, a complex involved in endoplasmic reticulum (ER)-Golgi transport by regulating the size of COPII coats. In response to cytosolic calcium increase, the heterodimer formed with PDCD6 interacts with, and bridges together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export, which is required for neural crest specification. Its role in the heterodimer formed with PDCD6 is however unclear: some evidence shows that PEF1 and PDCD6 work together and promote association between PDCD6 and SEC31 in presence of calcium. Other reports show that PEF1 dissociates from PDCD6 in presence of calcium, and may act as a negative regulator of PDCD6 (By similarity). Also acts as a negative regulator of ER-Golgi transport; possibly by inhibiting interaction between PDCD6 and SEC31 (PubMed:27276012)., [UniProtKB, PubMed, UniProtKB]; This work identifies for the first time a clear steady state role for a PEF protein in ER-to-Golgi transport-peflin is a negative regulator of transport. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity;GO:0046983 protein dimerization activity;GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0031463 Cul3-RING ubiquitin ligase complex;GO:0030127 COPII vesicle coat", "go_biological_process": "GO:0014029 neural crest formation;GO:0051592 response to calcium ion;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0014032 neural crest cell development;GO:0048208 COPII vesicle coating", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q641Z8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27321-1", "uniprot_id": [ { "id": "ICAL_RAT", "url": "https://www.uniprot.org/uniprot/P27321", "type": "external" } ], "mass": 77313.0, "length": 713, "protein_name": "Calpastatin", "gene_name": "Cast", "organism": "Rat", "refseq_name": "calpastatin isoform b", "refseq_ac": [ { "id": "NP_001028887", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028887", "type": "external" } ], "gene_names_uniprotkb": "Cast", "gene_names_refseq": "Cast", "protein_names_uniprotkb": "Calpastatin; Calpain inhibitor", "protein_names_refseq": "calpain inhibitor; calpastatin isoform b", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061); PLACK syndrome (Disease Ontology:DOID:0070526); congenital myasthenic syndrome 1A (Disease Ontology:DOID:0110663); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); Sjogren's syndrome (Disease Ontology:DOID:12894); Plasmodium falciparum malaria (Disease Ontology:DOID:14067); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); brain ischemia (Disease Ontology:DOID:2316); rheumatoid arthritis (Disease Ontology:DOID:7148); muscular atrophy (Disease Ontology:DOID:767); vasculitis (Disease Ontology:DOID:865); psoriasis (Disease Ontology:DOID:8893); systemic lupus erythematosus (Disease Ontology:DOID:9074); pemphigus (Disease Ontology:DOID:9182); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:25403); (R-RNO-1474228)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "1730065;17570336;19020622;19020623;2015306;22673903;29393594;9475181", "class_list": "", "function": "Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 17, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5GXY4;A5GXY5;A5GXY6;A5GXY7;A5GXY8;A5GXY9;A5GXZ7;O55151;O55152;O55153;Q5BK19;Q99MG1;Q99MG2", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity;GO:0004869 cysteine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:0010466 negative regulation of peptidase activity;GO:1990709 presynaptic active zone organization;GO:0001889 liver development;GO:0043086 negative regulation of catalytic activity;GO:0007520 myoblast fusion", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P27321-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JMC1-1", "uniprot_id": [ { "id": "PI5PA_RAT", "url": "https://www.uniprot.org/uniprot/Q9JMC1", "type": "external" } ], "mass": 107208.0, "length": 1001, "protein_name": "Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A", "gene_name": "Inpp5j", "organism": "Rat", "refseq_name": "phosphatidylinositol 4,5-bisphosphate 5-phosphatase A", "refseq_ac": [ { "id": "NP_598246", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598246", "type": "external" } ], "gene_names_uniprotkb": "Inpp5j; Pib5pa; Pipp", "gene_names_refseq": "Inpp5j; Inpp; Pib5pa; Pipp", "protein_names_uniprotkb": "Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A; 3.1.3.36; 3.1.3.56; Inositol polyphosphate 5-phosphatase J; Phosphatidylinositol 1,3,4,5-tetrakisphosphate 5-phosphatase; Phosphatidylinositol 1,4,5-trisphosphate 5-phosphatase; Proline-rich inositol polyphosphate 5-phosphatase", "protein_names_refseq": "phosphatidylinositol 1,3,4,5-tetrakisphosphate 5-phosphatase; phosphatidylinositol 1,4,5-trisphosphate 5-phosphatase; phosphatidylinositol 4,5-bisphosphate 5-phosphatase A; proline-rich inositol polyphosphate 5-phosphatase", "tax_id": 10116, "disease": "", "pathway": " (rno:171088); (R-RNO-1660499); (R-RNO-1855183); (R-RNO-1855204)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "10593988;11812139;11932254;21550974;22673903", "class_list": "", "function": "Crystal structure of an enzyme displaying both inositol-polyphosphate-1-phosphatase and 3'-phosphoadenosine-5'-phosphate phosphatase activities: a novel target of lithium therapy, [RefSeq, PubMed]; Inositol 5-phosphatase, which converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro (PubMed:10593988). May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles (PubMed:10593988)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Inositol polyphosphate 1-phosphatase is a novel antihypertrophic factor., [RefSeq, PubMed]; PIPP and CRMP2 exert opposing roles in promoting axon selection and neurite elongation and the complex between these proteins serves to regulate the localization of effectors that promote neurite extension., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.95", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.95", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" } ], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity;GO:0004445 inositol-polyphosphate 5-phosphatase activity;GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity;GO:0052659 inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030426 growth cone;GO:0043198 dendritic shaft;GO:0043005 neuron projection", "go_biological_process": "GO:0010977 negative regulation of neuron projection development;GO:0033137 negative regulation of peptidyl-serine phosphorylation;GO:0046856 phosphatidylinositol dephosphorylation;GO:0031115 negative regulation of microtubule polymerization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9JMC1-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K0D3-1", "uniprot_id": [ { "id": "LMOD1_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K0D3", "type": "external" } ], "mass": 66216.0, "length": 595, "protein_name": "Leiomodin-1", "gene_name": "Lmod1", "organism": "Rat", "refseq_name": "leiomodin-1 isoform 1", "refseq_ac": [ { "id": "NP_001100649", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100649", "type": "external" } ], "gene_names_uniprotkb": "Lmod1", "gene_names_refseq": "Lmod1", "protein_names_uniprotkb": "Leiomodin-1; SM-Lmod; Smooth muscle leiomodin", "protein_names_refseq": "SM-Lmod; leiomodin 1 (smooth muscle); leiomodin-1 isoform 1; smooth muscle leiomodin", "tax_id": 10116, "disease": "megacystis-microcolon-intestinal hypoperistalsis syndrome (Disease Ontology:DOID:0060610)", "pathway": " (rno:304816); (R-RNO-445355)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10520227;11350761;22157009;22673903", "class_list": "", "function": "Lmod1 is a new SMC-restricted SRF/MYOCD target gene., [RefSeq, PubMed]; Required for proper contractility of visceral smooth muscle cells (By similarity). Mediates nucleation of actin filaments (By similarity)., [UniProtKB, UniProtKB]; Required for proper contractility of visceral smooth muscle cells. Mediates nucleation of actin filaments., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005523 tropomyosin binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005884 actin filament;GO:0005865 striated muscle thin filament;GO:0030017 sarcomere;GO:0030016 myofibril", "go_biological_process": "GO:0006936 muscle contraction;GO:0007015 actin filament organization;GO:0045010 actin nucleation;GO:0030838 positive regulation of actin filament polymerization;GO:0051694 pointed-end actin filament capping", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A0G2K0D3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16086-1", "uniprot_id": [ { "id": "SPTN1_RAT", "url": "https://www.uniprot.org/uniprot/P16086", "type": "external" } ], "mass": 284637.0, "length": 2472, "protein_name": "Spectrin alpha chain, non-erythrocytic 1", "gene_name": "Gle1; Sptan1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gle1; Sptan1; Spna2; Spta2; Sptan1", "gene_names_refseq": "", "protein_names_uniprotkb": "Spectrin alpha chain, non-erythrocytic 1; Alpha-II spectrin; Fodrin alpha chain", "protein_names_refseq": "", "tax_id": 10116, "disease": "hereditary spastic paraplegia 91 (Disease Ontology:DOID:0070643); developmental and epileptic encephalopathy 5 (Disease Ontology:DOID:0080438); autosomal dominant distal hereditary motor neuronopathy 11 (Disease Ontology:DOID:0081400)", "pathway": " (rno:64159); (R-RNO-264870); (R-RNO-375165); (R-RNO-445095); (R-RNO-5673001); (R-RNO-6798695); (R-RNO-6807878); (R-RNO-9013420); (R-RNO-9013424)", "pathway_count": 9, "publication_count": 8, "publication_id_list": "11971983;15994232;16641100;18683930;22673903;23897824;2753883;38843836", "class_list": "", "function": "Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 22, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88663;P70477", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0051015 actin filament binding;GO:0005509 calcium ion binding;GO:0030507 spectrin binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030054 cell junction", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0051693 actin filament capping;GO:0016973 poly(A)+ mRNA export from nucleus", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P16086-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54923-1", "uniprot_id": [ { "id": "EXOC6_RAT", "url": "https://www.uniprot.org/uniprot/O54923", "type": "external" } ], "mass": 93178.0, "length": 804, "protein_name": "Exocyst complex component 6", "gene_name": "Exoc6", "organism": "Rat", "refseq_name": "exocyst complex component 6", "refseq_ac": [ { "id": "NP_062150", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062150", "type": "external" } ], "gene_names_uniprotkb": "Exoc6; Sec15a; Sec15l1; Sec15", "gene_names_refseq": "Exoc6; Sec15l1; Sec15", "protein_names_uniprotkb": "Exocyst complex component 6; Exocyst complex component Sec15A; SEC15-like protein 1; rSec15", "protein_names_refseq": "SEC15-like 1; SEC15-like protein 1; exocyst complex component 6; exocyst complex component Sec15A; rSec15", "tax_id": 10116, "disease": "", "pathway": " (rno:50556); (R-RNO-264876); (R-RNO-5620916)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "12954101;20890297;9405631", "class_list": "", "function": "Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Together with RAB11A, RAB3IP, RAB8A, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030426 growth cone;GO:0048471 perinuclear region of cytoplasm;GO:0090543 Flemming body;GO:0000145 exocyst", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0030218 erythrocyte differentiation;GO:0006887 exocytosis;GO:0006893 Golgi to plasma membrane transport;GO:0090522 vesicle tethering involved in exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O54923-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FVF1-1", "uniprot_id": [ { "id": "F10C1_RAT", "url": "https://www.uniprot.org/uniprot/Q5FVF1", "type": "external" } ], "mass": 37119.0, "length": 315, "protein_name": "Protein FRA10AC1 homolog", "gene_name": "Fra10ac1", "organism": "Rat", "refseq_name": "protein FRA10AC1 homolog", "refseq_ac": [ { "id": "NP_001014268", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014268", "type": "external" } ], "gene_names_uniprotkb": "Fra10ac1", "gene_names_refseq": "Fra10ac1; RGD1309482", "protein_names_uniprotkb": "Protein FRA10AC1 homolog", "protein_names_refseq": "fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1; protein FRA10AC1 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:365458)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "May be involved in pre-mRNA splicing., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016791 phosphatase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5FVF1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q505J8-1", "uniprot_id": [ { "id": "SYFA_RAT", "url": "https://www.uniprot.org/uniprot/Q505J8", "type": "external" } ], "mass": 57720.0, "length": 508, "protein_name": "Phenylalanine--tRNA ligase alpha subunit", "gene_name": "Farsa; Syce2", "organism": "Rat", "refseq_name": "phenylalanine--tRNA ligase alpha subunit", "refseq_ac": [ { "id": "NP_001019408", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019408", "type": "external" } ], "gene_names_uniprotkb": "Farsa; Syce2; Farsa; Farsla; Syce2", "gene_names_refseq": "Farsa; Farsla", "protein_names_uniprotkb": "Phenylalanine--tRNA ligase alpha subunit; 6.1.1.20; PheRS; Phenylalanyl-tRNA synthetase alpha subunit", "protein_names_refseq": "pheRS; phenylalanine--tRNA ligase alpha chain; phenylalanine--tRNA ligase alpha subunit; phenylalanine-tRNA synthetase-like, alpha subunit; phenylalanyl-tRNA synthetase alpha chain; phenylalanyl-tRNA synthetase, alpha subunit", "tax_id": 10116, "disease": "", "pathway": " (rno:288917)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "29393594;3880707;38843836", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.1.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.20", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0000049 tRNA binding;GO:0004826 phenylalanine-tRNA ligase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0009328 phenylalanine-tRNA ligase complex;GO:0005737 cytoplasm;GO:0000801 central element;GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0051290 protein heterotetramerization;GO:0006432 phenylalanyl-tRNA aminoacylation;GO:0007130 synaptonemal complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q505J8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18297-1", "uniprot_id": [ { "id": "SPRE_RAT", "url": "https://www.uniprot.org/uniprot/P18297", "type": "external" } ], "mass": 28128.0, "length": 262, "protein_name": "Sepiapterin reductase", "gene_name": "Spr", "organism": "Rat", "refseq_name": "sepiapterin reductase", "refseq_ac": [ { "id": "NP_062054", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062054", "type": "external" } ], "gene_names_uniprotkb": "Spr", "gene_names_refseq": "Spr", "protein_names_uniprotkb": "Sepiapterin reductase; 1.1.1.153; SPR", "protein_names_refseq": "sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase); sepiapterin reductase", "tax_id": 10116, "disease": "sepiapterin reductase deficiency (Disease Ontology:DOID:0111168); Parkinson's disease (Disease Ontology:DOID:14330); dystonia (Disease Ontology:DOID:543)", "pathway": " (rno:29270); (R-RNO-1474151); (R-RNO-203615)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10350607;11825621;2201030;2260974;22673903;36908807", "class_list": "", "function": "Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin., [UniProtKB]; Ninety-six-hour starved peripheral blood mononuclear cell supernatant inhibited LA7 breast cancer stem cells induced tumor via reduction in angiogenesis and alternations in Gch1 and Spr expressions. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.153", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0004757 sepiapterin reductase (NADP+) activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0050882 voluntary musculoskeletal movement;GO:0008284 positive regulation of cell population proliferation;GO:0040014 regulation of multicellular organism growth;GO:0042428 serotonin metabolic process;GO:0042417 dopamine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P18297-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04276-1", "uniprot_id": [ { "id": "VTDB_RAT", "url": "https://www.uniprot.org/uniprot/P04276", "type": "external" } ], "mass": 53544.0, "length": 476, "protein_name": "Vitamin D-binding protein", "gene_name": "Gc", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gc; Dbp", "gene_names_refseq": "", "protein_names_uniprotkb": "Vitamin D-binding protein; DBP; Gc-globulin; Group-specific component; VDB", "protein_names_refseq": "", "tax_id": 10116, "disease": "primary progressive multiple sclerosis (Disease Ontology:DOID:0050784); pre-eclampsia (Disease Ontology:DOID:10591); sciatic neuropathy (Disease Ontology:DOID:11446); osteoporosis (Disease Ontology:DOID:11476); dengue disease (Disease Ontology:DOID:12205); Graves' disease (Disease Ontology:DOID:12361); neurodegenerative disease (Disease Ontology:DOID:1289); uveitis (Disease Ontology:DOID:13141); hepatic encephalopathy (Disease Ontology:DOID:13413); rheumatic fever (Disease Ontology:DOID:1586); brain ischemia (Disease Ontology:DOID:2316); multiple sclerosis (Disease Ontology:DOID:2377); asthma (Disease Ontology:DOID:2841); endometriosis (Disease Ontology:DOID:289); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); arthritis (Disease Ontology:DOID:848); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (R-RNO-196791)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "2007578;21454685;22673903;2419332;2480956;3713442", "class_list": "", "function": "Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 24, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0090482 vitamin transmembrane transporter activity;GO:0003779 actin binding;GO:0005499 vitamin D binding;GO:1902118 calcidiol binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0030424 axon;GO:0048471 perinuclear region of cytoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0042359 vitamin D metabolic process;GO:0031667 response to nutrient levels;GO:0007565 female pregnancy;GO:0048545 response to steroid hormone;GO:0032355 response to estradiol", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P04276-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46720-1", "uniprot_id": [ { "id": "SO1A1_RAT", "url": "https://www.uniprot.org/uniprot/P46720", "type": "external" } ], "mass": 74178.0, "length": 670, "protein_name": "Solute carrier organic anion transporter family member 1A1", "gene_name": "Slco1a1", "organism": "Rat", "refseq_name": "solute carrier organic anion transporter family member 1A1", "refseq_ac": [ { "id": "NP_058807", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058807", "type": "external" } ], "gene_names_uniprotkb": "Slco1a1; Oatp1a1; Oatp1; Slc21a1", "gene_names_refseq": "OATP-1; Oatp1; Slc21a1; Slc21a3; Slco1a1", "protein_names_uniprotkb": "Solute carrier organic anion transporter family member 1A1; OATP-1; Organic anion-transporting polypeptide 1; Sodium-independent organic anion transporter 1; Solute carrier family 21 member 1", "protein_names_refseq": "organic anion-transporting polypeptide 1; sodium-independent organic anion transporter 1; solute carrier family (organic anion transporter) member 1; solute carrier family (organic anion transporter) member 3; solute carrier family 21 member 1; solute carrier organic anion transporter family member 1A1-like; solute carrier organic anion transporter family member 1A1", "tax_id": 10116, "disease": "fumarase deficiency (Disease Ontology:DOID:0111261); primary biliary cholangitis (Disease Ontology:DOID:12236); Dubin-Johnson syndrome (Disease Ontology:DOID:12308); lung non-small cell carcinoma (Disease Ontology:DOID:3908); leiomyomatosis (Disease Ontology:DOID:5138)", "pathway": " (rno:50572)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "11981753;12006354;15994332;16519530;18308854;19129463;22673903;24393554;25581836;26254357;27780379;31102415;8278353", "class_list": "", "function": "Bile transporters OATP1/MRP2 mRNA expression ratio in liver tissue decreased with dimethylnitrosamine-induced liver injury, model of liver cirrhosis., [RefSeq, PubMed]; Mediates the Na(+)-independent transport of organic anions such as steroid sulfate conjugates (dehydroepiandrosterone sulfate (DHEAS), 17-beta-glucuronosyl estradiol, estrone-3-sulfate), conjugated (taurocholate) and unconjugated (cholate) bile acids, prostaglandin E2 (PGE2) and L-thyroxine T4 (PubMed:19129463). Also capable of transporting sulfobromophthalein (BSP), ouabain and gadoxetate (By similarity). Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions (PubMed:19129463). Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment (PubMed:19129463)., [UniProtKB, PubMed, UniProtKB]; Oatp1a1 and Oatp2b1 expression levels are decreased by intestinal ischemia reperfusion., [RefSeq, PubMed]; Oatp1a1 has a role in acute liver congestion as seen in gadoxetate disodium-enhanced MRI, [RefSeq, PubMed]; Optimal rOATP1A4 trafficking to the cell surface is dependent upon coexpression and interaction with rOATP1A1., [RefSeq, PubMed]; Results suggest that urinary E(2)-17betaG excretion is subject to hormonal regulation and that the large gender difference can be explained by regulation in Oatp1-mediated reabsorption, [RefSeq, PubMed]; These findings suggest the possibility that ABCC2-mediated hepatobiliary excretion and OATP1/OATP2-mediated hepatic uptake do not play important roles in the disposition of regorafenib., [RefSeq, PubMed]; Transport of the sulfated, amidated bile acid, sulfolithocholyltaurine, into rat hepatocytes is mediated by Oatp1 and Oatp2., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015125 bile acid transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0015721 bile acid and bile salt transport;GO:0015711 organic anion transport;GO:0035634 response to stilbenoid;GO:0043252 sodium-independent organic anion transport", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P46720-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63025-1", "uniprot_id": [ { "id": "VAMP3_RAT", "url": "https://www.uniprot.org/uniprot/P63025", "type": "external" } ], "mass": 11480.0, "length": 103, "protein_name": "Vesicle-associated membrane protein 3", "gene_name": "Vamp3", "organism": "Rat", "refseq_name": "vesicle-associated membrane protein 3", "refseq_ac": [ { "id": "NP_476438", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476438", "type": "external" } ], "gene_names_uniprotkb": "Vamp3; Syb3", "gene_names_refseq": "Vamp3", "protein_names_uniprotkb": "Vesicle-associated membrane protein 3; CEB; Cellubrevin; Synaptobrevin-3; VAMP-3", "protein_names_refseq": "CEB; VAMP-3; cellubrevin; synaptobrevin-3; vesicle-associated membrane protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:29528); (R-RNO-1236974); (R-RNO-6811440); (R-RNO-8856825); (R-RNO-8856828); (R-RNO-8980692); (R-RNO-9013026); (R-RNO-9013106); (R-RNO-9013149); (R-RNO-9013404); (R-RNO-9013406); (R-RNO-9013407); (R-RNO-9013408); (R-RNO-9013423); (R-RNO-9035034)", "pathway_count": 15, "publication_count": 5, "publication_id_list": "22673903;25008321;27551042;8175689;8332193", "class_list": "", "function": "In vivo silencing of VAMP2 but not VAMP3 in TALs blunted cAMP-stimulated steady-state surface NKCC2 expression and completely blocked cAMP-stimulated NKCC2 exocytic delivery, [RefSeq, PubMed]; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network., [UniProtKB, UniProtKB]; VAMP3 is required for normal NKCC2 expression, renal function, and blood pressure., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q64271", "ec_number_list": [], "go_molecular_function": "GO:0000149 SNARE binding;GO:0005484 SNAP receptor activity;GO:0017075 syntaxin-1 binding", "go_cellular_component": "GO:0097708 intracellular vesicle;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0034446 substrate adhesion-dependent cell spreading;GO:0016192 vesicle-mediated transport;GO:0001921 positive regulation of receptor recycling;GO:0043001 Golgi to plasma membrane protein transport;GO:0042147 retrograde transport, endosome to Golgi", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P63025-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62747-1", "uniprot_id": [ { "id": "SYT7_RAT", "url": "https://www.uniprot.org/uniprot/Q62747", "type": "external" } ], "mass": 45482.0, "length": 403, "protein_name": "Synaptotagmin-7", "gene_name": "Syt7", "organism": "Rat", "refseq_name": "synaptotagmin-7 isoform 7", "refseq_ac": [ { "id": "NP_067691", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067691", "type": "external" } ], "gene_names_uniprotkb": "Syt7", "gene_names_refseq": "Syt7; SytVII", "protein_names_uniprotkb": "Synaptotagmin-7; Protein Syt7; Synaptotagmin VII; SytVII", "protein_names_refseq": "protein Syt7; synaptotagmin VII; synaptotagmin-7 isoform 7", "tax_id": 10116, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:59267)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10725327;11395007;11511344;11823420;12071850;15456748;17190793;18508778;22673903;27771350;28111077;32058590;38843836;39000085;7791877", "class_list": "", "function": "Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory and synaptic vesicles through Ca(2+) and phospholipid binding to the C2 domain (PubMed:10725327, PubMed:11395007, PubMed:11511344). Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (PubMed:11395007). SYT7 binds Ca(2+) with high affinity and slow kinetics compared to other synaptotagmins (By similarity). Involved in Ca(2+)-triggered lysosomal exocytosis, a major component of the plasma membrane repair (PubMed:10725327, PubMed:11511344). Ca(2+)-regulated delivery of lysosomal membranes to the cell surface is also involved in the phagocytic uptake of particles by macrophages. Ca(2+)-triggered lysosomal exocytosis also plays a role in bone remodeling by regulating secretory pathways in osteoclasts and osteoblasts. Involved in cholesterol transport from lysosome to peroxisome by promoting membrane contacts between lysosomes and peroxisomes: probably acts by promoting vesicle fusion by binding phosphatidylinositol-4,5-bisphosphate on peroxisomal membranes. Acts as a key mediator of synaptic facilitation, a process also named short-term synaptic potentiation: synaptic facilitation takes place at synapses with a low initial release probability and is caused by influx of Ca(2+) into the axon terminal after spike generation, increasing the release probability of neurotransmitters. Probably mediates synaptic facilitation by directly increasing the probability of release. May also contribute to synaptic facilitation by regulating synaptic vesicle replenishment, a process required to ensure that synaptic vesicles are ready for the arrival of the next action potential: SYT7 is required for synaptic vesicle replenishment by acting as a sensor for Ca(2+) and by forming a complex with calmodulin. Also acts as a regulator of Ca(2+)-dependent insulin and glucagon secretion in beta-cells. Triggers exocytosis by promoting fusion pore opening and fusion pore expansion in chromaffin cells (By similarity). Also regulates the secretion of some non-synaptic secretory granules of specialized cells (PubMed:15456748)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]; In somata of Purkinje neurons in the cerebellar cortex, both SYT7 (and SYNCRIP) were expressed and co-localized., [RefSeq, PubMed]; Region-Related Differences in Short-Term Synaptic Plasticity and Synaptotagmin-7 in the Male and Female Hippocampus of a Rat Model of Fragile X Syndrome. Publication Status: Online-Only, [RefSeq, PubMed]; Synaptotagmin-7 enhances calcium-sensing of chromaffin cell granules and slows discharge of granule cargos., [RefSeq, PubMed]; The slowed endocytosis phenotype previously reported after syt1 loss of function can also be triggered by other manipulations that promote asynchronous release such as Sr(2+) substitution and complexin loss of function. The link between asynchronous release and slowed endocytosis was due to selective targeting of fused synaptic vesicles toward slow retrieval by the asynchronous release Ca(2+) sensor synaptotagmin-7., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1M262;Q99J98;Q99P33;Q99P34;Q99P35;Q99P36;Q99P37;Q99P38", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0005509 calcium ion binding;GO:0019905 syntaxin binding;GO:0005544 calcium-dependent phospholipid binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0005829 cytosol", "go_biological_process": "GO:0001778 plasma membrane repair;GO:0006909 phagocytosis;GO:0014059 regulation of dopamine secretion;GO:0050796 regulation of insulin secretion;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q62747-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SWT4-1", "uniprot_id": [ { "id": "IWS1_RAT", "url": "https://www.uniprot.org/uniprot/Q3SWT4", "type": "external" } ], "mass": 85448.0, "length": 764, "protein_name": "Protein IWS1 homolog", "gene_name": "Iws1", "organism": "Rat", "refseq_name": "protein IWS1 homolog isoform 1", "refseq_ac": [ { "id": "NP_001030090", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030090", "type": "external" } ], "gene_names_uniprotkb": "Iws1; Iws1l", "gene_names_refseq": "Iws1; RGD1304762", "protein_names_uniprotkb": "Protein IWS1 homolog; IWS1-like protein", "protein_names_refseq": "IWS1, SUPT6H interacting protein; IWS1-like protein; protein IWS1 homolog isoform 1; protein IWS1 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:291705); (R-RNO-112382); (R-RNO-674695); (R-RNO-75955)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 44, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0001701 in utero embryonic development;GO:0006338 chromatin remodeling;GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3SWT4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05175-1", "uniprot_id": [ { "id": "BASP1_RAT", "url": "https://www.uniprot.org/uniprot/Q05175", "type": "external" } ], "mass": 21790.0, "length": 220, "protein_name": "Brain acid soluble protein 1", "gene_name": "Basp1", "organism": "Rat", "refseq_name": "brain acid soluble protein 1", "refseq_ac": [ { "id": "NP_071636", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071636", "type": "external" } ], "gene_names_uniprotkb": "Basp1; Nap22", "gene_names_refseq": "Basp1; NAP22", "protein_names_uniprotkb": "Brain acid soluble protein 1; 22 kDa neuronal tissue-enriched acidic protein; Neuronal axonal membrane protein NAP-22", "protein_names_refseq": "22 kDa neuronal tissue-enriched acidic protein; brain acid soluble protein 1; brain acidic membrane protein; neuronal axonal membrane protein NAP-22", "tax_id": 10116, "disease": "", "pathway": " (rno:64160); (R-RNO-9035034)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "14988044;22673903;23376695;23579388;25470949;29604406;8193160;8390468;9310187", "class_list": "", "function": "In rat brain, the amounts of all BASP1 forms per cell systematically increase during development and remain at the highest levels in adult animals., [RefSeq, PubMed]; NAP-22 could participate in the transport of GAD65 and GAD67 to the presynaptic termini and their retention on the synaptic vesicles as an anchoring protein., [RefSeq, PubMed]; Regulates functions in the motor, sensory and autonomic nerve terminals in the peripheral nervous system, [RefSeq, PubMed]; Study suggests the participation of NAP-22 in the membrane cycling through binding to dynamin and acidic membrane lipids at the presynaptic region., [RefSeq, PubMed]; We conclude that BASP1 oligomer is a non-pathological physiologically relevant functional form of this protein., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0019904 protein domain specific binding;GO:0003714 transcription corepressor activity;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016607 nuclear speck;GO:0030426 growth cone", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0045892 negative regulation of DNA-templated transcription;GO:0097435 supramolecular fiber organization;GO:0072112 podocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q05175-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U2X2-1", "uniprot_id": [ { "id": "SPAG1_RAT", "url": "https://www.uniprot.org/uniprot/Q5U2X2", "type": "external" } ], "mass": 100615.0, "length": 893, "protein_name": "Sperm-associated antigen 1", "gene_name": "Spag1", "organism": "Rat", "refseq_name": "sperm-associated antigen 1", "refseq_ac": [ { "id": "NP_001012116", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012116", "type": "external" } ], "gene_names_uniprotkb": "Spag1", "gene_names_refseq": "Spag1", "protein_names_uniprotkb": "Sperm-associated antigen 1; HSD-3.8; Infertility-related sperm protein Spag-1", "protein_names_refseq": "HSD-3.8; infertility-related sperm protein Spag-1; sperm-associated antigen 1", "tax_id": 10116, "disease": "primary ciliary dyskinesia 28 (Disease Ontology:DOID:0110607)", "pathway": " (rno:315033)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11517287;22673903", "class_list": "", "function": "May play a role in the cytoplasmic assembly of the ciliary dynein arms (By similarity). Binds GTP and has GTPase activity (By similarity). Plays a role in fertilization (PubMed:11517287)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005525 GTP binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0101031 protein folding chaperone complex;GO:0120293 dynein axonemal particle", "go_biological_process": "GO:0007338 single fertilization;GO:0070286 axonemal dynein complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5U2X2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q642A3-1", "uniprot_id": [ { "id": "S31F3_RAT", "url": "https://www.uniprot.org/uniprot/Q642A3", "type": "external" } ], "mass": 36941.0, "length": 329, "protein_name": "Protein SPATA31F3", "gene_name": "Spata31f3", "organism": "Rat", "refseq_name": "protein SPATA31F3", "refseq_ac": [ { "id": "NP_001019514", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019514", "type": "external" } ], "gene_names_uniprotkb": "Spata31f3; Fam205c", "gene_names_refseq": "Fam205cp; Fam205c; Spata31f3", "protein_names_uniprotkb": "Protein SPATA31F3; Protein FAM205C", "protein_names_refseq": "family with sequence similarity 205, member C, pseudogene; protein FAM205CP homolog; protein SPATA31F3; transmembrane protein ENSP00000340100 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:500445)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q642A3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJ79-1", "uniprot_id": [ { "id": "DYHC2_RAT", "url": "https://www.uniprot.org/uniprot/Q9JJ79", "type": "external" } ], "mass": 492218.0, "length": 4306, "protein_name": "Cytoplasmic dynein 2 heavy chain 1", "gene_name": "Dync2h1", "organism": "Rat", "refseq_name": "cytoplasmic dynein 2 heavy chain 1", "refseq_ac": [ { "id": "NP_075413", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075413", "type": "external" } ], "gene_names_uniprotkb": "Dync2h1; Dhc1b; Dlp4; Dnch2; Dnchc2", "gene_names_refseq": "Dhc1b; Dnch2; Dnchc2; Dync2h1", "protein_names_uniprotkb": "Cytoplasmic dynein 2 heavy chain 1; Cytoplasmic dynein 2 heavy chain; Dynein cytoplasmic heavy chain 2; Dynein heavy chain isotype 1B; Dynein-like protein 4", "protein_names_refseq": "cytoplasmic dynein 2 heavy chain 1-like; cytoplasmic dynein 2 heavy chain 1; cytoplasmic dynein heavy chain 2; dynein heavy chain isotype 1B; dynein, cytoplasmic, heavy chain 2; dynein, cytoplasmic, heavy polypeptide 2; dynein-like protein 4", "tax_id": 10116, "disease": "nonsyndromic deafness (Disease Ontology:DOID:0050563); asphyxiating thoracic dystrophy (Disease Ontology:DOID:0050592); asphyxiating thoracic dystrophy 3 (Disease Ontology:DOID:0110087); VACTERL association (Disease Ontology:DOID:14679)", "pathway": " (rno:65209); (R-RNO-5610787); (R-RNO-5620924)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "11907264;12432068;7657712;8812413;8832411;9450951", "class_list": "", "function": "May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis. May play a role in transport between endoplasmic reticulum and Golgi or organization of the Golgi in cells (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P70576;Q63167", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008569 minus-end-directed microtubule motor activity;GO:0051959 dynein light intermediate chain binding;GO:0045505 dynein intermediate chain binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005874 microtubule;GO:0005886 plasma membrane;GO:0031514 motile cilium;GO:0045177 apical part of cell", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0060294 cilium movement involved in cell motility;GO:0007507 heart development;GO:0016485 protein processing;GO:0030900 forebrain development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JJ79-1", "record_type": "protein", "filter_code": "0000000.0000111.001000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09495-1", "uniprot_id": [ { "id": "TPM4_RAT", "url": "https://www.uniprot.org/uniprot/P09495", "type": "external" } ], "mass": 28510.0, "length": 248, "protein_name": "Tropomyosin alpha-4 chain", "gene_name": "Tpm4", "organism": "Rat", "refseq_name": "tropomyosin alpha-4 chain", "refseq_ac": [ { "id": "NP_036810", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036810", "type": "external" } ], "gene_names_uniprotkb": "Tpm4", "gene_names_refseq": "Tpm4.2cy; Tpm4.2; Tpm4", "protein_names_uniprotkb": "Tropomyosin alpha-4 chain; TM-4; Tropomyosin-4", "protein_names_refseq": "TM-4; tropomycin 4; tropomyosin alpha-4 chain", "tax_id": 10116, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930); blood platelet disease (Disease Ontology:DOID:2218)", "pathway": " (rno:24852); (R-RNO-390522); (R-RNO-445355); (R-RNO-9013424)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "2112608;22673903;3611091;7568216", "class_list": "", "function": "Binds to actin filaments in muscle and non-muscle cells (PubMed:7568216). Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction (By similarity). Smooth muscle contraction is regulated by interaction with caldesmon (By similarity). In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments (By similarity). Binds calcium (By similarity). Plays a role in platelet biogenesis., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0046982 protein heterodimerization activity;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005884 actin filament;GO:0015629 actin cytoskeleton;GO:0002102 podosome;GO:0001725 stress fiber", "go_biological_process": "GO:0006936 muscle contraction;GO:0007015 actin filament organization;GO:0030220 platelet formation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P09495-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54748-1", "uniprot_id": [ { "id": "STK3_RAT", "url": "https://www.uniprot.org/uniprot/O54748", "type": "external" } ], "mass": 56122.0, "length": 491, "protein_name": "Serine/threonine-protein kinase 3", "gene_name": "Stk3", "organism": "Rat", "refseq_name": "serine/threonine-protein kinase 3", "refseq_ac": [ { "id": "NP_113923", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113923", "type": "external" } ], "gene_names_uniprotkb": "Stk3; Mst2", "gene_names_refseq": "MST2; Stk3", "protein_names_uniprotkb": "Serine/threonine-protein kinase 3; 2.7.11.1; MST-2; Mammalian STE20-like protein kinase 2; STE20-like kinase MST2", "protein_names_refseq": "MST-2; STE20-like kinase MST2; mammalian STE20-like protein kinase 2; serine/threonine kinase 3 (STE20 homolog, yeast); serine/threonine-protein kinase 3", "tax_id": 10116, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); cancer (Disease Ontology:DOID:162); carcinoma (Disease Ontology:DOID:305); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:65189); (R-RNO-2028269)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "12554736;22673903;31847471;9430685", "class_list": "", "function": "STK3/4 Expression Is Regulated in Uterine Endometrial Cells during the Estrous Cycle. Publication Status: Online-Only, [RefSeq, PubMed]; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates NKX2-1. Phosphorylates NEK2 and plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with SAV1, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation. Positively regulates RAF1 activation via suppression of the inhibitory phosphorylation of RAF1 on 'Ser-259'. Phosphorylates MOBKL1A and RASSF2. Phosphorylates MOBKL1B on 'Thr-74'. Acts cooperatively with MOBKL1B to activate STK38 (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.4.22.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.56", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0032991 protein-containing complex", "go_biological_process": "GO:0046621 negative regulation of organ growth;GO:0060706 cell differentiation involved in embryonic placenta development;GO:0006468 protein phosphorylation;GO:0008285 negative regulation of cell population proliferation;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O54748-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIM5-1", "uniprot_id": [ { "id": "CDV3_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIM5", "type": "external" } ], "mass": 24310.0, "length": 236, "protein_name": "Protein CDV3 homolog", "gene_name": "Cdv3", "organism": "Rat", "refseq_name": "protein CDV3 homolog isoform 2", "refseq_ac": [ { "id": "NP_001014119", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014119", "type": "external" } ], "gene_names_uniprotkb": "Cdv3", "gene_names_refseq": "Cdv3", "protein_names_uniprotkb": "Protein CDV3 homolog", "protein_names_refseq": "carnitine deficiency-associated gene expressed in ventricle 3 homolog; protein CDV3 homolog isoform 2; protein CDV3 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:315970)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XIM5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R4Z9-1", "uniprot_id": [ { "id": "MFN1_RAT", "url": "https://www.uniprot.org/uniprot/Q8R4Z9", "type": "external" } ], "mass": 83847.0, "length": 741, "protein_name": "Mitofusin-1", "gene_name": "Mfn1", "organism": "Rat", "refseq_name": "mitofusin-1", "refseq_ac": [ { "id": "NP_620432", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620432", "type": "external" } ], "gene_names_uniprotkb": "Mfn1; Fzo1b", "gene_names_refseq": "Fzo1b; Mfn1", "protein_names_uniprotkb": "Mitofusin-1; 3.6.5.-; Mitochondrial transmembrane GTPase FZO1B; Transmembrane GTPase MFN1", "protein_names_refseq": "mitochondrial transmembrane GTPase FZO1B; mitofusin-1; transmembrane GTPase MFN1", "tax_id": 10116, "disease": "Charcot-Marie-Tooth disease type 2 (Disease Ontology:DOID:0050539); Charcot-Marie-Tooth disease type 2A2A (Disease Ontology:DOID:0110155); Charcot-Marie-Tooth disease type 2A2B (Disease Ontology:DOID:0111557); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); Alzheimer's disease (Disease Ontology:DOID:10652); adult respiratory distress syndrome (Disease Ontology:DOID:11394); dental fluorosis (Disease Ontology:DOID:13711); primary pulmonary hypertension (Disease Ontology:DOID:14557); status epilepticus (Disease Ontology:DOID:1824); acute kidney failure (Disease Ontology:DOID:3021); rhinitis (Disease Ontology:DOID:4483); migraine (Disease Ontology:DOID:6364); pulmonary hypertension (Disease Ontology:DOID:6432); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (rno:192647); (R-RNO-5205685); (R-RNO-9013419); (R-RNO-983231)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "12589796;14561718;14592431;17105775;29445732;30659190;33347533;35192161;36689810", "class_list": "", "function": "Elongation of mitochondria was observed at 4 h after cardiac arrest, whereas fragmented mitochondria were significantly increased, along with concomitant increase in the fission proteins Drp1 and Fis1 and a reduction in the fusion proteins Mfn1 and Mfn2 at 12 h and 24 h after cardiac arrest, [RefSeq, PubMed]; MiR-20b suppresses mitochondrial dysfunction-mediated apoptosis to alleviate hyperoxia-induced acute lung injury by directly targeting MFN1 and MFN2., [RefSeq, PubMed]; Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:12589796, PubMed:14561718). Membrane clustering requires GTPase activity. It may involve a major rearrangement of the coiled coil domains (By similarity). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:14561718). Overexpression induces the formation of mitochondrial networks (in vitro) (PubMed:14561718). Has low GTPase activity (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; Mitofusin 1 and 2 differentially regulate mitochondrial function underlying Ca[2+] signaling and proliferation in rat aortic smooth muscle cells., [RefSeq, PubMed]; The Mfn1-betaIIPKC Interaction Regulates Mitochondrial Dysfunction via Sirt3 Following Experimental Subarachnoid Hemorrhage. Erratum:[Transl Stroke Res. 2024 Aug;15(4):861-862. doi: 10.1007/s12975-024-01253-w. PMID: 38750251], [RefSeq, PubMed]; We characterized two rat mitochondrial outer membrane proteins, Mfn1 and Mfn2, with distinct tissue expressions, that are homologous to Drosophila Fzo, a GTPase involved in mitochondrial fusion., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane;GO:0016020 membrane;GO:0098799 outer mitochondrial membrane protein complex", "go_biological_process": "GO:0010636 positive regulation of mitochondrial fusion;GO:1905395 response to flavonoid;GO:1990910 response to hypobaric hypoxia;GO:0045471 response to ethanol;GO:0051592 response to calcium ion", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8R4Z9-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R500-1", "uniprot_id": [ { "id": "MFN2_RAT", "url": "https://www.uniprot.org/uniprot/Q8R500", "type": "external" } ], "mass": 86123.0, "length": 757, "protein_name": "Mitofusin-2", "gene_name": "Mfn2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mfn2; Fzo1a", "gene_names_refseq": "", "protein_names_uniprotkb": "Mitofusin-2; 3.6.5.-; Mitochondrial transmembrane GTPase FZO1A; Protein HSG; Transmembrane GTPase MFN2", "protein_names_refseq": "", "tax_id": 10116, "disease": "Charcot-Marie-Tooth disease type 2 (Disease Ontology:DOID:0050539); Charcot-Marie-Tooth disease type 6 (Disease Ontology:DOID:0080068); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Charcot-Marie-Tooth disease type 2A2A (Disease Ontology:DOID:0110155); Charcot-Marie-Tooth disease type 2A2B (Disease Ontology:DOID:0111557); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); prediabetes syndrome (Disease Ontology:DOID:11716); carotid stenosis (Disease Ontology:DOID:13001); multiple symmetric lipomatosis (Disease Ontology:DOID:14116); primary pulmonary hypertension (Disease Ontology:DOID:14557); depressive disorder (Disease Ontology:DOID:1596); transient cerebral ischemia (Disease Ontology:DOID:224); pulmonary fibrosis (Disease Ontology:DOID:3770); myocardial infarction (Disease Ontology:DOID:5844); diabetic retinopathy (Disease Ontology:DOID:8947); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (R-RNO-5205685); (R-RNO-9013419); (R-RNO-983231)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "12589796;12598526;14561718;14592431;15322553;17105775", "class_list": "", "function": "Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:12589796, PubMed:12598526, PubMed:14561718, PubMed:15322553). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events. Overexpression induces the formation of mitochondrial networks. Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (By similarity). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes (PubMed:12598526). Plays an important role in the regulation of vascular smooth muscle cell proliferation (PubMed:15322553). Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Is required for PRKN recruitment to dysfunctional mitochondria (By similarity). Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress (By similarity). Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 20, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O09013", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding;GO:0051020 GTPase binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0060299 negative regulation of sarcomere organization;GO:1903427 negative regulation of reactive oxygen species biosynthetic process;GO:2000866 positive regulation of estradiol secretion;GO:0046580 negative regulation of Ras protein signal transduction;GO:2000386 positive regulation of ovarian follicle development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8R500-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FVN1-1", "uniprot_id": [ { "id": "STBD1_RAT", "url": "https://www.uniprot.org/uniprot/Q5FVN1", "type": "external" } ], "mass": 35494.0, "length": 333, "protein_name": "Starch-binding domain-containing protein 1", "gene_name": "Stbd1", "organism": "Rat", "refseq_name": "starch-binding domain-containing protein 1", "refseq_ac": [ { "id": "NP_001014010", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014010", "type": "external" } ], "gene_names_uniprotkb": "Stbd1", "gene_names_refseq": "RGD1311800; Stbd1", "protein_names_uniprotkb": "Starch-binding domain-containing protein 1; Genethonin-1; Glycophagy cargo receptor stbd1", "protein_names_refseq": "genethonin-1; glycophagy cargo receptor stbd1; starch-binding domain-containing protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:305234); (R-RNO-6798695); (R-RNO-8980692); (R-RNO-9013404); (R-RNO-9013408); (R-RNO-9013423)", "pathway_count": 6, "publication_count": 2, "publication_id_list": "20810658;22673903", "class_list": "", "function": "Acts as a cargo receptor for glycogen. Delivers its cargo to an autophagic pathway called glycophagy, resulting in the transport of glycogen to lysosomes., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Stbd1 is involved in glycogen metabolism by binding to glycogen and anchoring it to membranes, thereby affecting its cellular localization and its intracellular trafficking to lysosomes. Erratum:[J Biol Chem. 2011 Nov 11;286(45):39673], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030247 polysaccharide binding;GO:0019899 enzyme binding;GO:2001070 starch binding;GO:2001069 glycogen binding;GO:0038024 cargo receptor activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007041 lysosomal transport;GO:0061723 glycophagy;GO:0061753 substrate localization to autophagosome;GO:0005980 glycogen catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5FVN1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CGU9-1", "uniprot_id": [ { "id": "TPH2_RAT", "url": "https://www.uniprot.org/uniprot/Q8CGU9", "type": "external" } ], "mass": 55621.0, "length": 485, "protein_name": "Tryptophan 5-hydroxylase 2", "gene_name": "Tph2", "organism": "Rat", "refseq_name": "tryptophan 5-hydroxylase 2", "refseq_ac": [ { "id": "NP_776211", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776211", "type": "external" } ], "gene_names_uniprotkb": "Tph2; Ntph", "gene_names_refseq": "Ntph; Tph2", "protein_names_uniprotkb": "Tryptophan 5-hydroxylase 2; 1.14.16.4; Neuronal tryptophan hydroxylase; Tryptophan 5-monooxygenase 2", "protein_names_refseq": "neuronal tryptophan hydroxylase; tryptophan 5-hydroxylase 2; tryptophan 5-monooxygenase 2", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); sleep apnea (Disease Ontology:DOID:0050847); autism spectrum disorder (Disease Ontology:DOID:0060041); traumatic brain injury (Disease Ontology:DOID:0081292); hypertension (Disease Ontology:DOID:10763); autistic disorder (Disease Ontology:DOID:12849); premature ejaculation (Disease Ontology:DOID:13709); major depressive disorder (Disease Ontology:DOID:1470); alcohol use disorder (Disease Ontology:DOID:1574); melancholic depression (Disease Ontology:DOID:1595); depressive disorder (Disease Ontology:DOID:1596); cystitis (Disease Ontology:DOID:1679); anxiety disorder (Disease Ontology:DOID:2030); post-traumatic stress disorder (Disease Ontology:DOID:2055); psychotic disorder (Disease Ontology:DOID:2468); bipolar disorder (Disease Ontology:DOID:3312); panic disorder (Disease Ontology:DOID:594); acute stress disorder (Disease Ontology:DOID:6088); premenstrual tension (Disease Ontology:DOID:727); subacute delirium (Disease Ontology:DOID:8645); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:317675); (R-RNO-209931)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "12511643;12911638;15194882;22673903;36868221;37848703;38732220", "class_list": "", "function": "A second tryptophan hydroxylase isoform detected in the brain, [RefSeq, PubMed]; Molecular and cellular mechanisms of the first social relationship: A conserved role of 5-HT from mice to monkeys, upstream of oxytocin., [RefSeq, PubMed]; Poor Decision Making and Sociability Impairment Following Central Serotonin Reduction in Inducible TPH2-Knockdown Rats. Publication Status: Online-Only, [RefSeq, PubMed]; TPH1 mRNA expression was 105-fold more abundant in rat pineal than TPH2; TPH2 expression within the gland showed no significant variation with time of day and was very low., [RefSeq, PubMed]; The effect of brain serotonin deficit (TPH2-KO) on the expression and activity of liver cytochrome P450 enzymes in aging male Dark Agouti rats., [RefSeq, PubMed]; Tph1 and Tph2 transcripts showed robust diurnal rhythms of abundance, with highest levels at night., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 22, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.16.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.16.4", "type": "external" } ], "go_molecular_function": "GO:0004510 tryptophan 5-monooxygenase activity;GO:0005506 iron ion binding", "go_cellular_component": "GO:0030424 axon;GO:0043025 neuronal cell body;GO:0043005 neuron projection", "go_biological_process": "GO:0051592 response to calcium ion;GO:0031667 response to nutrient levels;GO:0051384 response to glucocorticoid;GO:0007623 circadian rhythm;GO:0014823 response to activity", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8CGU9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62623-1", "uniprot_id": [ { "id": "CDC20_RAT", "url": "https://www.uniprot.org/uniprot/Q62623", "type": "external" } ], "mass": 54829.0, "length": 499, "protein_name": "Cell division cycle protein 20 homolog", "gene_name": "Cdc20", "organism": "Rat", "refseq_name": "cell division cycle protein 20 homolog", "refseq_ac": [ { "id": "NP_741990", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_741990", "type": "external" } ], "gene_names_uniprotkb": "Cdc20", "gene_names_refseq": "Cdc20; p55cdc", "protein_names_uniprotkb": "Cell division cycle protein 20 homolog; p55CDC", "protein_names_refseq": "cell cycle protein p55CDC; cell division cycle 20 homolog; cell division cycle protein 20 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:64515); (R-RNO-141405); (R-RNO-141430); (R-RNO-141444); (R-RNO-174048); (R-RNO-174113); (R-RNO-174154); (R-RNO-174178); (R-RNO-174184); (R-RNO-176407); (R-RNO-176408); (R-RNO-176417); (R-RNO-179409); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-5663220); (R-RNO-5689880); (R-RNO-68877); (R-RNO-9648025); (R-RNO-983168)", "pathway_count": 20, "publication_count": 8, "publication_id_list": "19900895;20517887;21725312;22045811;35621027;36764621;7513050;9682218", "class_list": "", "function": "CDC20 inhibition alleviates fibrotic response of renal tubular epithelial cells and fibroblasts by regulating nuclear translocation of beta-catenin., [RefSeq, PubMed]; CDK2 blocks APC/CCdc20-mediated ubiquitylation of p21 at the N terminus, causing G2 arrest in mitogen-stimulated cardiomyocytes, [RefSeq, PubMed]; Findings define a Cdc20-APC(anaphase promoting complex) ubiquitin signaling pathway that governs presynaptic development, which holds important implications for neuronal connectivity and plasticity in the brain, [RefSeq, PubMed]; Substrate-specific adapter and activator of the anaphase promoting complex/cyclosome (APC/C) complex that confers substrate specificity by binding to substrates and targeting them to the APC/C complex for ubiquitination and degradation (By similarity). Essential for activating APC/C in the metaphase/anaphase transition of the cell cycle, targeting the degradation of cyclin B and securin (By similarity). Recognizes and binds the destruction box (D box), KEB box and ABBA motifs on protein substrates (By similarity). The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons (By similarity). CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation (By similarity). The CDC20-APC/C complex promotes proper dilation formation and radial migration by degrading CCDC41 (By similarity). Component of the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation until all chromosomes are properly attached to the mitotic spindle (By similarity). The MCC, which consists of CDC20, MAD2L1/MAD2, BUB1B/BUBR1 and BUB3, is a key player of the spindle assembly checkpoint (By similarity). The MCC-bound APC/C complex is inactive and this delays the metaphase/anaphase transition (By similarity). When the spindle assembly checkpoint is silenced, the MCC-APC/C complex recruits the E2 enzyme UBCH10 and triggers the auto-ubiquitination of CDC20 in the MCC, thereby reactivating APC/C for transition into anaphase (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Substrate-specific adapter of the anaphase promoting complex/cyclosome (APC/C) complex that confers substrate specificity by binding to substrates and targeting them to the APC/C complex for ubiquitination and degradation. Recognizes and binds the destruction box (D box) on protein substrates. Involved in the metaphase/anaphase transition of cell cycle. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation. The CDC20-APC/C complex promotes proper dilation formation and radial migration by degrading CCDC41., [UniProtKB, UniProtKB]; The functional roles of Cdc20 protein is involved in the cell cycle, mitosis, and apoptosis in CBRH-7919 cells., [RefSeq, PubMed]; Up-regulation of cell division cycle 20 expression alters the morphology of neuronal dendritic spines in the nucleus accumbens by promoting FMRP ubiquitination., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O70380;Q5U360", "ec_number_list": [], "go_molecular_function": "GO:0042826 histone deacetylase binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity;GO:0010997 anaphase-promoting complex binding;GO:1990757 ubiquitin ligase activator activity;GO:0097027 ubiquitin-protein transferase activator activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005813 centrosome;GO:0048471 perinuclear region of cytoplasm;GO:0000776 kinetochore;GO:0005680 anaphase-promoting complex", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0051301 cell division;GO:0090307 mitotic spindle assembly;GO:0016567 protein ubiquitination;GO:0031145 anaphase-promoting complex-dependent catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q62623-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R1K2-1", "uniprot_id": [ { "id": "TEN2_RAT", "url": "https://www.uniprot.org/uniprot/Q9R1K2", "type": "external" } ], "mass": 307474.0, "length": 2774, "protein_name": "Teneurin-2", "gene_name": "Tenm2", "organism": "Rat", "refseq_name": "teneurin-2", "refseq_ac": [ { "id": "NP_064473", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064473", "type": "external" } ], "gene_names_uniprotkb": "Tenm2; Odz2; Tnm2", "gene_names_refseq": "Lasso; Odz2; Tenm2", "protein_names_uniprotkb": "Teneurin-2; Neurestin; Protein Odd Oz/ten-m homolog 2; Ten-2; Ten-m2; Tenascin-M2; Teneurin transmembrane protein 2", "protein_names_refseq": "neurestin; odz, odd Oz/ten-m homolog 2; protein Odd Oz/ten-m homolog 2; ten-2; ten-m2; tenascin-M2; teneurin-2-like; teneurin-2", "tax_id": 10116, "disease": "", "pathway": " (rno:117242)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10419693;21724987;22673903;24090084;38843836", "class_list": "", "function": "Induces gene transcription inhibition., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Involved in neural development, regulating the establishment of proper connectivity within the nervous system (PubMed:21724987). Acts as a ligand of the ADGRL1 and ADGRL3 receptors that are expressed at the surface of adjacent cells (By similarity). Promotes the formation of filopodia and enlarged growth cone in neuronal cells (By similarity). Mediates axon guidance and homophilic and heterophilic cell-cell adhesion (PubMed:21724987). May function as a cellular signal transducer (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Latrophilin 1 and its endogenous ligand Lasso/teneurin-2 form a high-affinity transsynaptic receptor pair with signaling capabilities., [RefSeq, PubMed]", "predicted_glycosites": 15, "predicted_n_glycosites": 14, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 16, "binding_glycan_count": 0, "secondary_ac_list": "Q9R1J9;Q9R1K0;Q9R1K1", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098890 extrinsic component of postsynaptic membrane;GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0098942 retrograde trans-synaptic signaling by trans-synaptic protein complex;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007165 signal transduction;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9R1K2-1", "record_type": "protein", "filter_code": "0000000.0000101.001000.000000000000001000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ESC2-1", "uniprot_id": [ { "id": "TNMD_RAT", "url": "https://www.uniprot.org/uniprot/Q9ESC2", "type": "external" } ], "mass": 36971.0, "length": 317, "protein_name": "Tenomodulin", "gene_name": "Tnmd", "organism": "Rat", "refseq_name": "tenomodulin", "refseq_ac": [ { "id": "NP_071626", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071626", "type": "external" } ], "gene_names_uniprotkb": "Tnmd; Chm1l", "gene_names_refseq": "ChM1L; Tnmd", "protein_names_uniprotkb": "Tenomodulin; ChM1L; Chondromodulin-1-like protein; Myodulin; TeM; rChM1L; rTeM", "protein_names_refseq": "chondromodulin-1-like protein; chondromodulin-I-like protein; myodulin; rChM1L; rTeM; teM; tenomodulin", "tax_id": 10116, "disease": "", "pathway": " (rno:64104)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11162640;18337200;19780194;22673903;28750046;30307981;34066472;36513131", "class_list": "", "function": "Data show that chondromodulin-I (ChM-1) and tenomodulin (TeM) are differentially expressed in mandibular condylar and other growth cartilages., [RefSeq, PubMed]; May be an angiogenesis inhibitor., [UniProtKB]; Mechanical stretch facilitates tenomodulin expression to induce tenocyte migration via MAPK signaling pathway., [RefSeq, PubMed]; Stretch-Induced Tenomodulin Expression Promotes Tenocyte Migration via F-Actin and Chromatin Remodeling. Publication Status: Online-Only, [RefSeq, PubMed]; Study in Sprague-Dawley rats demonstrated that 10 Hz vertical vibration stimulated the anabolic effect of tenocytes and the stiffness of intact Achilles tendons by increasing the expression of TGF-beta1, which was followed by an increased expression of tenomodulin and type I collagen that then improved Achilles tendon stiffness via mechano-transduction. Publication Status: Online-Only, [RefSeq, PubMed]; Wnt/beta-catenin decreased Mkx and Tnmd expressions without suppressing Scx expression in Scx-programmed tendon progenitors. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0001937 negative regulation of endothelial cell proliferation;GO:0016525 negative regulation of angiogenesis;GO:0071773 cellular response to BMP stimulus;GO:0001886 endothelial cell morphogenesis;GO:0035990 tendon cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9ESC2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22985-1", "uniprot_id": [ { "id": "XDH_RAT", "url": "https://www.uniprot.org/uniprot/P22985", "type": "external" } ], "mass": 146243.0, "length": 1331, "protein_name": "Xanthine dehydrogenase/oxidase", "gene_name": "Xdh", "organism": "Rat", "refseq_name": "xanthine dehydrogenase/oxidase", "refseq_ac": [ { "id": "NP_058850", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058850", "type": "external" } ], "gene_names_uniprotkb": "Xdh", "gene_names_refseq": "XOR; Xdh", "protein_names_uniprotkb": "Xanthine dehydrogenase/oxidase; XOR; Xanthine oxidoreductase", "protein_names_refseq": "xanthine dehydrogenase/oxidase; xanthine oxidase; xanthine oxidoreductase", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); renal fibrosis (Disease Ontology:DOID:0050855); xanthinuria (Disease Ontology:DOID:0060236); xanthinuria type I (Disease Ontology:DOID:0070452); muscular disease (Disease Ontology:DOID:0080000); interstitial nephritis (Disease Ontology:DOID:1063); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); cardiovascular system disease (Disease Ontology:DOID:1287); cholestasis (Disease Ontology:DOID:13580); Lesch-Nyhan syndrome (Disease Ontology:DOID:1919); hyperuricemia (Disease Ontology:DOID:1920); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); acute kidney failure (Disease Ontology:DOID:3021); carotid artery disease (Disease Ontology:DOID:3407); pancreatitis (Disease Ontology:DOID:4989); hepatocellular carcinoma (Disease Ontology:DOID:684); chronic kidney disease (Disease Ontology:DOID:784); peritonitis (Disease Ontology:DOID:8283); cataract (Disease Ontology:DOID:83); multiple myeloma (Disease Ontology:DOID:9538); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:497811); (R-RNO-74259); (R-RNO-8851680); (R-RNO-9748787)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "11993848;15878860;17301076;2387845;27585949;28025796;30059711;38358003;8208609", "class_list": "", "function": "Abdominal paracentesis drainage protects rats against severe acute pancreatitis-associated lung injury by reducing the mobilization of intestinal xanthine dehydrogenase., [RefSeq, PubMed]; Analysis of cysteine disulfide bonds and crystal structure of a non-convertible rat liver xanthine dehydrogenase mutant GeneRIF: Rat Xdh is a moonlighting protein that has two distinct catalytic activities as a dehydrogenase and an oxidase., [RefSeq, PubMed]; Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species., [UniProtKB, PubMed, UniProtKB, UniProtKB]; S-allyl cysteine as potent anti-gout drug: Insight into the xanthine oxidase inhibition and anti-inflammatory activity., [RefSeq, PubMed]; The presence of xanthine dehydrogenase is crucial for the maturation of the rat kidneys., [RefSeq, PubMed]; The results thus demonstrate that XO mediates oxidative stress in MB+PQ-treated rat PMNs via iNOS-independent but cytokine (predominantly IFN-gamma)-dependent mechanism., [RefSeq, PubMed]; This gene encodes a member of the xanthine dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein is involved in purine degradation and functions as both a dehydrogenase and an oxidase. [provided by RefSeq, Jan 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 23, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q63157", "ec_number_list": [ { "id": "1.17.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.17.1.4", "type": "external" }, { "id": "1.17.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.17.3.2", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0050660 flavin adenine dinucleotide binding;GO:0071949 FAD binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005777 peroxisome;GO:0005829 cytosol;GO:0016529 sarcoplasmic reticulum;GO:0005576 extracellular region", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0034465 response to carbon monoxide;GO:0006154 adenosine catabolic process;GO:0032496 response to lipopolysaccharide;GO:0042542 response to hydrogen peroxide", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P22985-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIM7-1", "uniprot_id": [ { "id": "SYK_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIM7", "type": "external" } ], "mass": 71623.0, "length": 626, "protein_name": "Lysine--tRNA ligase", "gene_name": "Kars1", "organism": "Rat", "refseq_name": "lysine--tRNA ligase isoform 1", "refseq_ac": [ { "id": "NP_001006968", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006968", "type": "external" } ], "gene_names_uniprotkb": "Kars1; Kars", "gene_names_refseq": "Kars1; Kars; LysRS", "protein_names_uniprotkb": "Lysine--tRNA ligase; 2.7.7.-; 6.1.1.6; LysRS; Lysyl-tRNA synthetase", "protein_names_refseq": "lysine--tRNA ligase isoform 1; lysine--tRNA ligase", "tax_id": 10116, "disease": "hypomyelinating leukoencephalopathy (Disease Ontology:DOID:0050987); Charcot-Marie-Tooth disease recessive intermediate B (Disease Ontology:DOID:0110204); autosomal recessive nonsyndromic deafness 89 (Disease Ontology:DOID:0110534); sciatic neuropathy (Disease Ontology:DOID:11446)", "pathway": " (rno:292028); (R-RNO-9856649)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "19524539;22673903;23159739;2995387;3988754;6315704", "class_list": "", "function": "Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (PubMed:6315704). When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages (By similarity). Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity (PubMed:19524539, PubMed:2995387, PubMed:3988754)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.1.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.15", "type": "external" }, { "id": "6.1.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.17", "type": "external" }, { "id": "6.1.1.10", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.10", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "6.1.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.19", "type": "external" }, { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" }, { "id": "3.9.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.-", "type": "external" }, { "id": "2.7.7.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.-", "type": "external" }, { "id": "6.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.6", "type": "external" }, { "id": "6.1.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.18", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0016597 amino acid binding;GO:0000049 tRNA binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0043032 positive regulation of macrophage activation;GO:0015966 diadenosine tetraphosphate biosynthetic process;GO:0045893 positive regulation of DNA-templated transcription;GO:0070371 ERK1 and ERK2 cascade;GO:0010165 response to X-ray", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q5XIM7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04692-1", "uniprot_id": [ { "id": "TPM1_RAT", "url": "https://www.uniprot.org/uniprot/P04692", "type": "external" } ], "mass": 32681.0, "length": 284, "protein_name": "Tropomyosin alpha-1 chain", "gene_name": "Tpm1", "organism": "Rat", "refseq_name": "tropomyosin alpha-1 chain isoform Tpm1.6cy", "refseq_ac": [ { "id": "NP_001029241", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029241", "type": "external" } ], "gene_names_uniprotkb": "Tpm1; Alpha-tm; Tpma", "gene_names_refseq": "Alpha-tm; Tma2; Tmsa; Tpm1", "protein_names_uniprotkb": "Tropomyosin alpha-1 chain; Alpha-tropomyosin; Tropomyosin-1", "protein_names_refseq": "hepatoma alpha tropomyosin; smooth muscle alpha-tropomyosin; striated muscle alpha-tropomyosin; tropomyosin 1, alpha; tropomyosin 3 alpha; tropomyosin alpha-1 chain isoform Tpm1.6cy; tropomyosin-alpha", "tax_id": 10116, "disease": "familial hypertrophic cardiomyopathy (Disease Ontology:DOID:0080326); hypertrophic cardiomyopathy 3 (Disease Ontology:DOID:0110309); dilated cardiomyopathy 1Y (Disease Ontology:DOID:0110457); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (rno:24851); (R-RNO-390522); (R-RNO-445355)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "2022655;22673903;22812662;2320008;23609439;24362038;26109417;28002632;30462572;3352602;34502162;3558368;37037889;3838802;6179945;7568216", "class_list": "", "function": "Binds to actin filaments in muscle and non-muscle cells (PubMed:22812662, PubMed:7568216). Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction (PubMed:22812662). Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments., [UniProtKB, PubMed, PubMed]; CaMKII regulates the proteins TPM1 and MYOM2 and promotes diacetylmorphine-induced abnormal cardiac rhythms. Publication Status: Online-Only, [RefSeq, PubMed]; Hypoxia and hyperoxia differentially control proliferation of rat neural crest stem cells via distinct regulatory pathways of the HIF1alpha-CXCR4 and TP53-TPM1 proteins, [RefSeq, PubMed]; The R21H mutation causes a twofold decrease in tropomyosin's affinity for F-actin and affects leiomodin's function., [RefSeq, PubMed]; The link between flexibility of TM and its function in ejecting hearts., [RefSeq, PubMed]; Transmission of stability information through the N-domain of tropomyosin is interrupted by a stabilizing mutation (A109L) in the hydrophobic core of the stability control region (residues 97-118)., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "P06469;P18342;P18343;P18344;P19354;Q53X09;Q63582;Q63608;Q63609", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005884 actin filament;GO:0015629 actin cytoskeleton;GO:0001725 stress fiber;GO:0032587 ruffle membrane", "go_biological_process": "GO:0003065 positive regulation of heart rate by epinephrine;GO:0001701 in utero embryonic development;GO:0006936 muscle contraction;GO:0007015 actin filament organization;GO:0045785 positive regulation of cell adhesion", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P04692-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JHU6-1", "uniprot_id": [ { "id": "STMN3_RAT", "url": "https://www.uniprot.org/uniprot/Q9JHU6", "type": "external" } ], "mass": 20895.0, "length": 180, "protein_name": "Stathmin-3", "gene_name": "Stmn3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Stmn3; Sclip", "gene_names_refseq": "", "protein_names_uniprotkb": "Stathmin-3; SCG10-like protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:29246)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16038898;22673903", "class_list": "", "function": "Exhibits microtubule-destabilizing activity, which is antagonized by STAT3., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0051087 protein-folding chaperone binding;GO:0015631 tubulin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0030426 growth cone;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0031110 regulation of microtubule polymerization or depolymerization;GO:0031175 neuron projection development;GO:1990090 cellular response to nerve growth factor stimulus;GO:0010977 negative regulation of neuron projection development;GO:0051493 regulation of cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9JHU6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41516-1", "uniprot_id": [ { "id": "TOP2A_RAT", "url": "https://www.uniprot.org/uniprot/P41516", "type": "external" } ], "mass": 173221.0, "length": 1526, "protein_name": "DNA topoisomerase 2-alpha", "gene_name": "Top2a", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Top2a; Top-2; Top2", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA topoisomerase 2-alpha; 5.6.2.2; DNA topoisomerase II, alpha isozyme", "protein_names_refseq": "", "tax_id": 10116, "disease": "ductal carcinoma in situ (Disease Ontology:DOID:0060074); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); penile benign neoplasm (Disease Ontology:DOID:11624); limited scleroderma (Disease Ontology:DOID:1577); diffuse scleroderma (Disease Ontology:DOID:1580); cancer (Disease Ontology:DOID:162); B cell deficiency (Disease Ontology:DOID:2115); nephroblastoma (Disease Ontology:DOID:2154); pulmonary fibrosis (Disease Ontology:DOID:3770); lung non-small cell carcinoma (Disease Ontology:DOID:3908); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (rno:360243); (R-RNO-4615885)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "20554522;22673903;8390253", "class_list": "", "function": "Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (By similarity). May play a role in regulating the period length of BMAL1 transcriptional oscillation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 21, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.2", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" } ], "go_molecular_function": "GO:0008301 DNA binding, bending;GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity;GO:0000287 magnesium ion binding;GO:0003677 DNA binding;GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0000775 chromosome, centromeric region", "go_biological_process": "GO:0000712 resolution of meiotic recombination intermediates;GO:0007059 chromosome segregation;GO:0043065 positive regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P41516-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WU70-1", "uniprot_id": [ { "id": "STXB5_RAT", "url": "https://www.uniprot.org/uniprot/Q9WU70", "type": "external" } ], "mass": 127659.0, "length": 1152, "protein_name": "Syntaxin-binding protein 5", "gene_name": "Stxbp5", "organism": "Rat", "refseq_name": "syntaxin-binding protein 5 isoform m", "refseq_ac": [ { "id": "NP_110470", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_110470", "type": "external" } ], "gene_names_uniprotkb": "Stxbp5; Llgl3", "gene_names_refseq": "Stxbp5", "protein_names_uniprotkb": "Syntaxin-binding protein 5; Lethal(2) giant larvae protein homolog 3; Tomosyn-1", "protein_names_refseq": "lethal(2) giant larvae protein homolog 3; syntaxin-binding protein 5 isoform m; tomosyn-1", "tax_id": 10116, "disease": "", "pathway": " (rno:81022)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10066450;12782620;14983051;15316007;16186257;22673903;24782308;25063806;29269412;9620695", "class_list": "", "function": "Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane (By similarity). Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Competes with STXBP1 for STX1 binding., [UniProtKB, PubMed]; Plays a role in vesicle trafficking and exocytosis inhibition. In pancreatic beta-cells, inhibits insulin secretion probably by interacting with and regulating STX1A and STX4, key t-SNARE proteins involved in the fusion of insulin granules to the plasma membrane. Also plays a role in neurotransmitter release by inhibiting basal acetylcholine release from axon terminals and by preventing synaptic fatigue upon repetitive stimulation. Promotes as well axonal outgrowth., [UniProtKB, UniProtKB]; Tomo-1 overexpression increased dendritic spine density, whereas Tomo-1 knockdown (KD) decreased spine density., [RefSeq, PubMed]; Tomosyn inhibits the priming step and impairs the efficiency of vesicle pool refilling in a calcium-dependent manner., [RefSeq, PubMed]; Tomosyn is a soluble SNARE that directly competes with synaptobrevin in the formation of SNARE complexes and thus may function in down-regulating exocytosis., [RefSeq, PubMed]; Unstructured loops in the WD40 domain mediate tomosyn's binding to SNAP25 and are involved in tomosyn's organization on the plasma membrane., [RefSeq, PubMed]; We suggest that tomosyn uses its CTD to arrest SNARE-dependent fusion reactions, whereas its NTD is required for the recruitment of tomosyn to vesicle fusion sites through syntaxin interaction., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9WU71;Q9Z152", "ec_number_list": [], "go_molecular_function": "GO:0045159 myosin II binding;GO:0005096 GTPase activator activity;GO:0019905 syntaxin binding;GO:0017075 syntaxin-1 binding", "go_cellular_component": "GO:0098888 extrinsic component of presynaptic membrane;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex", "go_biological_process": "GO:0099504 synaptic vesicle cycle;GO:0015031 protein transport;GO:0006887 exocytosis;GO:0010807 regulation of synaptic vesicle priming;GO:0006893 Golgi to plasma membrane transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9WU70-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13599-1", "uniprot_id": [ { "id": "FCGRN_RAT", "url": "https://www.uniprot.org/uniprot/P13599", "type": "external" } ], "mass": 40169.0, "length": 366, "protein_name": "IgG receptor FcRn large subunit p51", "gene_name": "Fcgrt", "organism": "Rat", "refseq_name": "IgG receptor FcRn large subunit p51 precursor", "refseq_ac": [ { "id": "NP_203502", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_203502", "type": "external" } ], "gene_names_uniprotkb": "Fcgrt; Fcrn", "gene_names_refseq": "FcRn; Fcgrt", "protein_names_uniprotkb": "IgG receptor FcRn large subunit p51; FcRn; IgG Fc fragment receptor transporter alpha chain; Neonatal Fc receptor", "protein_names_refseq": "Fc fragment immunoglobulin G receptor; Fc fragment of IgG receptor and transporter; Fc fragment of IgG, receptor, transporter, alpha; Fc receptor, IgG, alpha chain transporter; IgG receptor FcRn large subunit p51 precursor; igG Fc fragment receptor transporter alpha chain; igG receptor FcRn large subunit p51; neonatal Fc receptor", "tax_id": 10116, "disease": "", "pathway": " (rno:29558)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "18818657;21454685;23220220;24802048;2534798;25658443;26887834;2911353;29393594;33283642;7298722;7969498;9493268", "class_list": "", "function": "Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk (PubMed:18818657, PubMed:7969498). IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids (PubMed:18818657, PubMed:7298722). Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation. In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Characterization and screening of IgG binding to the neonatal Fc receptor., [RefSeq, PubMed]; Mechanism of how carbamylation reduces albumin binding to FcRn contributing to increased vascular clearance., [RefSeq, PubMed]; Significant structural changes occur to albumin with glycation, particularly in the FcRn-binding region, which could explain the reduced affinity to FcRn, [RefSeq, PubMed]; The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity., [RefSeq, PubMed]; The suckling rat pup intestine is a mechanistic model of FcRn-IgG-mediated transcytosis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030881 beta-2-microglobulin binding;GO:0019864 IgG binding;GO:0019770 IgG receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0009897 external side of plasma membrane;GO:0010008 endosome membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0006955 immune response;GO:0006959 humoral immune response", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P13599-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WVJ4-1", "uniprot_id": [ { "id": "SYJ2B_RAT", "url": "https://www.uniprot.org/uniprot/Q9WVJ4", "type": "external" } ], "mass": 15825.0, "length": 145, "protein_name": "Synaptojanin-2-binding protein", "gene_name": "Synj2bp", "organism": "Rat", "refseq_name": "synaptojanin-2-binding protein", "refseq_ac": [ { "id": "NP_072121", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_072121", "type": "external" } ], "gene_names_uniprotkb": "Synj2bp; Omp25", "gene_names_refseq": "Omp25; Synj2bp", "protein_names_uniprotkb": "Synaptojanin-2-binding protein; Mitochondrial outer membrane protein 25; NPW16", "protein_names_refseq": "NPW16; mitochondrial outer membrane protein 25; synaptojanin-2-binding protein", "tax_id": 10116, "disease": "", "pathway": " (rno:64531)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10357812;15878399", "class_list": "", "function": "Regulates endocytosis of activin type 2 receptor kinases through the Ral/RALBP1-dependent pathway and may be involved in suppression of activin-induced signal transduction., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0JN00", "ec_number_list": [], "go_molecular_function": "GO:0070699 type II activin receptor binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0030100 regulation of endocytosis;GO:2000010 positive regulation of protein localization to cell surface;GO:0006605 protein targeting;GO:0007266 Rho protein signal transduction;GO:0001937 negative regulation of endothelial cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9WVJ4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JHI3-1", "uniprot_id": [ { "id": "SO2B1_RAT", "url": "https://www.uniprot.org/uniprot/Q9JHI3", "type": "external" } ], "mass": 74215.0, "length": 682, "protein_name": "Solute carrier organic anion transporter family member 2B1", "gene_name": "Slco2b1", "organism": "Rat", "refseq_name": "solute carrier organic anion transporter family member 2B1", "refseq_ac": [ { "id": "NP_542964", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_542964", "type": "external" } ], "gene_names_uniprotkb": "Slco2b1; Oatp2b1; Slc21a9", "gene_names_refseq": "OATP2B1; Slc21a9; Slco2b1; moat1", "protein_names_uniprotkb": "Solute carrier organic anion transporter family member 2B1; OATP2B1; Organic anion transporter moatp1; Organic anion transporting polypeptide 2B1; Solute carrier family 21 member 9", "protein_names_refseq": "multispecific organic anion transporter 1; organic anion transporter moatp1; organic anion transporting polypeptide 2B1; solute carrier family 21 (organic anion transporter), member 9; solute carrier family 21 member 9; solute carrier organic anion transporter family member 2B1", "tax_id": 10116, "disease": "pancreatic cancer (Disease Ontology:DOID:1793); liver cancer (Disease Ontology:DOID:3571)", "pathway": " (rno:140860); (R-RNO-189483); (R-RNO-879518); (R-RNO-9749641); (R-RNO-9754706)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "10973807;18500364;22673903;34284282;34628357;37533302", "class_list": "", "function": "Differences in transport function of the human and rat orthologue of the Organic Anion Transporting Polypeptide 2B1 (OATP2B1)., [RefSeq, PubMed]; Downregulated expression of organic anion transporting polypeptide (Oatp) 2b1 in the small intestine of rats with acute kidney injury., [RefSeq, PubMed]; Influence of Slco2b1-knockout and SLCO2B1-humanization on coproporphyrin I and III levels in rats., [RefSeq, PubMed]; Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins D2 (PGD2), E1 (PGE1) and E2 (PGE2), leukotriene C4, thromboxane B2 and L-thyroxine (PubMed:10973807). Also plays a role in the reuptake of neuropeptides such as substance P/TAC1 and vasoactive intestinal peptide/VIP released from retinal neurons. May act as a heme transporter that promotes cellular iron availability. Also transports heme by-product coproporphyrin III (CPIII), and may be involved in their hepatic disposition (By similarity). May contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (By similarity). Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment. The exact transport mechanism has not been yet deciphered but most likely involves an anion exchange, coupling the cellular uptake of organic substrate with the efflux of an anionic compound. Hydrogencarbonate/HCO3(-) acts as a probable counteranion that exchanges for organic anions. Cytoplasmic glutamate may also act as counteranion in the placenta (By similarity)., [UniProtKB, PubMed, UniProtKB]; The statin transporters Oatp1a4 and Oatp2b1 are expressed in rat skeletal myofibres, but not in satellite cells, fibroblasts or in L6 myoblasts, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015125 bile acid transmembrane transporter activity;GO:0015291 secondary active transmembrane transporter activity;GO:0015132 prostaglandin transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0009925 basal plasma membrane", "go_biological_process": "GO:0001889 liver development;GO:0008283 cell population proliferation;GO:0055085 transmembrane transport;GO:0006879 intracellular iron ion homeostasis;GO:0015721 bile acid and bile salt transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JHI3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62997-1", "uniprot_id": [ { "id": "TRA2B_RAT", "url": "https://www.uniprot.org/uniprot/P62997", "type": "external" } ], "mass": 33666.0, "length": 288, "protein_name": "Transformer-2 protein homolog beta", "gene_name": "Tra2b", "organism": "Rat", "refseq_name": "transformer-2 protein homolog beta", "refseq_ac": [ { "id": "NP_476460", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476460", "type": "external" } ], "gene_names_uniprotkb": "Tra2b; Sfrs10", "gene_names_refseq": "Sfrs10; Srsf10; Tra2b", "protein_names_uniprotkb": "Transformer-2 protein homolog beta; RA301; Splicing factor, arginine/serine-rich 10; TRA-2 beta; TRA2-beta; Transformer-2 protein homolog B", "protein_names_refseq": "RA301; TRA-2 beta; TRA2-beta; serine/arginine-rich splicing factor 10; splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila); transformer 2 beta homolog; transformer-2 protein homolog B; transformer-2 protein homolog beta", "tax_id": 10116, "disease": "macular degeneration (Disease Ontology:DOID:4448)", "pathway": " (rno:117259); (R-RNO-72163); (R-RNO-72203); (R-RNO-9013418); (R-RNO-9013422); (R-RNO-9770562)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "19282290;22673903;23977258;7499316;9671816", "class_list": "", "function": "Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing., [UniProtKB, UniProtKB]; Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Tra2beta regulates the expression of RGS4 gene and is induced by morphine. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O15449;Q15815;Q64283", "ec_number_list": [], "go_molecular_function": "GO:0036002 pre-mRNA binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0005681 spliceosomal complex;GO:0005637 nuclear inner membrane", "go_biological_process": "GO:0048026 positive regulation of mRNA splicing, via spliceosome;GO:0071333 cellular response to glucose stimulus;GO:0000302 response to reactive oxygen species;GO:0021796 cerebral cortex regionalization;GO:0043484 regulation of RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P62997-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15178-1", "uniprot_id": [ { "id": "SYDC_RAT", "url": "https://www.uniprot.org/uniprot/P15178", "type": "external" } ], "mass": 57126.0, "length": 501, "protein_name": "Aspartate--tRNA ligase, cytoplasmic", "gene_name": "Dars1; Mcm6", "organism": "Rat", "refseq_name": "aspartate--tRNA ligase, cytoplasmic", "refseq_ac": [ { "id": "NP_446251", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446251", "type": "external" } ], "gene_names_uniprotkb": "Dars1; Mcm6; Dars1; Dars; Drs1; Mcm6", "gene_names_refseq": "DRS1; Dars1; Dars; aspRS", "protein_names_uniprotkb": "Aspartate--tRNA ligase, cytoplasmic; 6.1.1.12; AspRS; Aspartyl-tRNA synthetase", "protein_names_refseq": "aspartate--tRNA ligase, cytoplasmic; aspartyl-tRNA synthetase, cytoplasmic", "tax_id": 10116, "disease": "", "pathway": " (rno:116483); (R-RNO-9856649)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "2642907;8973367", "class_list": "", "function": "Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity., [UniProtKB, UniProtKB, UniProtKB]; Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "6.1.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.15", "type": "external" }, { "id": "6.1.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.17", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "6.1.1.10", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.10", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "6.1.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.19", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.7.7.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.-", "type": "external" }, { "id": "6.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.6", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "6.1.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.18", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0004815 aspartate-tRNA ligase activity;GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0003677 DNA binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse;GO:0017101 aminoacyl-tRNA synthetase multienzyme complex;GO:0005634 nucleus", "go_biological_process": "GO:0006422 aspartyl-tRNA aminoacylation;GO:0006270 DNA replication initiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P15178-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZB51-1", "uniprot_id": [ { "id": "TUTLB_RAT", "url": "https://www.uniprot.org/uniprot/D3ZB51", "type": "external" } ], "mass": 145079.0, "length": 1328, "protein_name": "Protein turtle homolog B", "gene_name": "Igsf9b", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Igsf9b", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein turtle homolog B; Immunoglobulin superfamily member 9B", "protein_names_refseq": "", "tax_id": 10116, "disease": "depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (rno:315510)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;23751499", "class_list": "", "function": "Transmembrane protein which is abundantly expressed in interneurons, where it may regulate inhibitory synapse development (PubMed:23751499). May mediate homophilic cell adhesion (By similarity). Is involved in the organization and maintenance of axon initial segment (AIS) architecture, likely cooperating with PRICKLE2 to regulate ANK3/ANKG localization to AIS (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019900 kinase binding", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0014069 postsynaptic density;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007399 nervous system development;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0099560 synaptic membrane adhesion;GO:0097151 positive regulation of inhibitory postsynaptic potential", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZB51-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AY25-1", "uniprot_id": [ { "id": "TMED3_RAT", "url": "https://www.uniprot.org/uniprot/Q6AY25", "type": "external" } ], "mass": 25510.0, "length": 221, "protein_name": "Transmembrane emp24 domain-containing protein 3", "gene_name": "Tmed3", "organism": "Rat", "refseq_name": "transmembrane emp24 domain-containing protein 3 precursor", "refseq_ac": [ { "id": "NP_001004249", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004249", "type": "external" } ], "gene_names_uniprotkb": "Tmed3", "gene_names_refseq": "Tmed3", "protein_names_uniprotkb": "Transmembrane emp24 domain-containing protein 3; p24 family protein gamma-4; p24gamma4", "protein_names_refseq": "integral type I protein; p24 family protein gamma-4; p24gamma4; transmembrane emp24 domain containing 3; transmembrane emp24 domain-containing protein 3 precursor; transmembrane emp24 domain-containing protein 3; transmembrane emp24 protein transport domain containing 3", "tax_id": 10116, "disease": "", "pathway": " (rno:300888); (R-RNO-6807878); (R-RNO-6811434)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "11739402;15047867;15718469", "class_list": "", "function": "Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0005789 endoplasmic reticulum membrane;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0007030 Golgi organization;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6AY25-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91ZW6-1", "uniprot_id": [ { "id": "TMLH_RAT", "url": "https://www.uniprot.org/uniprot/Q91ZW6", "type": "external" } ], "mass": 49568.0, "length": 421, "protein_name": "Trimethyllysine dioxygenase, mitochondrial", "gene_name": "Tmlhe", "organism": "Rat", "refseq_name": "trimethyllysine dioxygenase, mitochondrial isoform 1", "refseq_ac": [ { "id": "NP_596878", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_596878", "type": "external" } ], "gene_names_uniprotkb": "Tmlhe; Tmlh", "gene_names_refseq": "Tmlhe; Tmlh", "protein_names_uniprotkb": "Trimethyllysine dioxygenase, mitochondrial; 1.14.11.8; Epsilon-trimethyllysine 2-oxoglutarate dioxygenase; TML dioxygenase; TML hydroxylase; TML-alpha-ketoglutarate dioxygenase; TMLD", "protein_names_refseq": "TML dioxygenase; TML hydroxylase; TML-alpha-ketoglutarate dioxygenase; TMLD; epsilon-trimethyllysine 2-oxoglutarate dioxygenase; epsilon-trimethyllysine hydroxylase; trimethyllysine dioxygenase, mitochondrial isoform 1; trimethyllysine dioxygenase, mitochondrial", "tax_id": 10116, "disease": "autistic disorder (Disease Ontology:DOID:12849)", "pathway": " (rno:170898); (R-RNO-71262)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "11431483", "class_list": "", "function": "Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML) in the carnitine biosynthesis pathway., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5U2P7", "ec_number_list": [ { "id": "1.14.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.8", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen;GO:0050353 trimethyllysine dioxygenase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0045329 carnitine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q91ZW6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70549-1", "uniprot_id": [ { "id": "NAC3_RAT", "url": "https://www.uniprot.org/uniprot/P70549", "type": "external" } ], "mass": 103163.0, "length": 927, "protein_name": "Sodium/calcium exchanger 3", "gene_name": "Slc8a3", "organism": "Rat", "refseq_name": "sodium/calcium exchanger 3 precursor", "refseq_ac": [ { "id": "NP_511175", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_511175", "type": "external" } ], "gene_names_uniprotkb": "Slc8a3; Ncx3", "gene_names_refseq": "Ncx3; Slc8a3", "protein_names_uniprotkb": "Sodium/calcium exchanger 3; Na(+)/Ca(2+)-exchange protein 3; Solute carrier family 8 member 3", "protein_names_refseq": "Na(+)/Ca(2+)-exchange protein 3; sodium/calcium exchanger 3 precursor; sodium/calcium exchanger 3; solute carrier family 8 (sodium/calcium exchanger), member 3", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); status epilepticus (Disease Ontology:DOID:1824); brain ischemia (Disease Ontology:DOID:2316)", "pathway": " (rno:140448); (R-RNO-418359); (R-RNO-425561); (R-RNO-5578775)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "12377375;16914199;21959935;23506867;26608990;26924806;28428550;29763795;8798769;9486131", "class_list": "", "function": "Analyze the equilibrium and kinetic properties of Ca(2+) binding to purified preparations of CBD1, CBD2, and CBD12 from NCX2 and from NCX3 splice variants, [RefSeq, PubMed]; Brain ischemia regulates gene expression levels of Na+/Ca2+ exchanger isoform NCX3, especially in cerebral cortex., [RefSeq, PubMed]; Data show a general mechanism for regulatory coupling associated with Ca2+ interactions with regulatory CBD domains of NCX1, NCX2, and NCX3 isoforms and their splice variants, where the dynamic effects of alternative splicing on conformational dynamics of the two-domain regulatory tandem (CBD12) control the contribution of a given isoform/splice variant to dynamic handling of cytosolic Ca2+ oscillations in many cell type. Publication Status: Online-Only, [RefSeq, PubMed]; Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed:8798769, PubMed:9486131). Contributes to cellular Ca(2+) homeostasis in excitable cells, both in muscle and in brain. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A3 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In neurons, contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory. Required for normal oligodendrocyte differentiation and for normal myelination. Mediates Ca(2+) efflux from mitochondria and contributes to mitochondrial Ca(2+) ion homeostasis., [UniProtKB, PubMed, PubMed, UniProtKB]; There is a significant reduction in NCX3 expression in rats with febrile convulsions., [RefSeq, PubMed]; This cardioprotective effect was potentially achieved via up-regulating p-AKT and SLC8A3., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0046872 metal ion binding;GO:0005432 calcium:sodium antiporter activity;GO:0015368 calcium:monoatomic cation antiporter activity;GO:1905060 calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol;GO:0005874 microtubule;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:1902532 negative regulation of intracellular signal transduction;GO:0007611 learning or memory;GO:0007612 learning;GO:0007613 memory;GO:0050808 synapse organization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P70549-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09739-1", "uniprot_id": [ { "id": "TNNT3_RAT", "url": "https://www.uniprot.org/uniprot/P09739", "type": "external" } ], "mass": 30750.0, "length": 259, "protein_name": "Troponin T, fast skeletal muscle", "gene_name": "Tnnt3", "organism": "Rat", "refseq_name": "troponin T, fast skeletal muscle isoform 11", "refseq_ac": [ { "id": "NP_001257593", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257593", "type": "external" } ], "gene_names_uniprotkb": "Tnnt3", "gene_names_refseq": "Tnnt3; Tnt", "protein_names_uniprotkb": "Troponin T, fast skeletal muscle; Fast skeletal muscle troponin T; TnTf; fTnT", "protein_names_refseq": "fTnT; fast skeletal muscle troponin T; tnTf; troponin T type 3 (skeletal, fast); troponin T, fast skeletal muscle isoform 11; troponin T, fast skeletal muscle; troponin T3, skeletal, fast", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); intrinsic cardiomyopathy (Disease Ontology:DOID:0060036); distal arthrogryposis type 2B (Disease Ontology:DOID:0111599); distal arthrogryposis type 2B2 (Disease Ontology:DOID:0111601); nemaline myopathy (Disease Ontology:DOID:3191)", "pathway": " (rno:24838); (R-RNO-390522)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "16839517;21490260;22673903;2986851;3735424", "class_list": "", "function": "Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Weight-dependent quantitative variation in Tnnt3 alternative splicing appears to be an evolutionarily conserved feature of skeletal muscle., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P09740;Q304F4;Q4PPA0", "ec_number_list": [], "go_molecular_function": "GO:0030172 troponin C binding;GO:0031014 troponin T binding;GO:0048306 calcium-dependent protein binding;GO:0005523 tropomyosin binding;GO:0031013 troponin I binding", "go_cellular_component": "GO:0005861 troponin complex", "go_biological_process": "GO:0003009 skeletal muscle contraction;GO:0006936 muscle contraction;GO:0045214 sarcomere organization;GO:0006942 regulation of striated muscle contraction;GO:0043462 regulation of ATP-dependent activity", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P09739-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48500-1", "uniprot_id": [ { "id": "TPIS_RAT", "url": "https://www.uniprot.org/uniprot/P48500", "type": "external" } ], "mass": 26849.0, "length": 249, "protein_name": "Triosephosphate isomerase", "gene_name": "Tpi1l2; Tpi1", "organism": "Rat", "refseq_name": "triosephosphate isomerase", "refseq_ac": [ { "id": "NP_075211", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075211", "type": "external" } ], "gene_names_uniprotkb": "Tpi1l2; Tpi1; RGD1563601; Tpi1l2", "gene_names_refseq": "Tpi1; Tpi", "protein_names_uniprotkb": "Triosephosphate isomerase; 4.2.3.3; 5.3.1.1; Methylglyoxal synthase; TIM; Triose-phosphate isomerase", "protein_names_refseq": "TIM; methylglyoxal synthase; triose-phosphate isomerase; triosephosphate isomerase-like; triosephosphate isomerase", "tax_id": 10116, "disease": "triosephosphate isomerase deficiency (Disease Ontology:DOID:0050884); neurodegenerative disease (Disease Ontology:DOID:1289); cancer (Disease Ontology:DOID:162); carbohydrate metabolic disorder (Disease Ontology:DOID:2978); ocular hypertension (Disease Ontology:DOID:9282)", "pathway": " (rno:24849); (rno:498731); (R-RNO-70171); (R-RNO-70263)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "18683930;22420779;22673903;34502162;35111160", "class_list": "", "function": "Data show statistically significant altered levels of Tpi1 and alteration of Hk1, Aldoc, Pgam1 and Gapdh with borderline significance in phencyclidine (PCP) rats compared to controls. Publication Status: Online-Only, [RefSeq, PubMed]; It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Metabolic Enzyme Triosephosphate Isomerase 1 and Nicotinamide Phosphoribosyltransferase, Two Independent Inflammatory Indicators in Rheumatoid Arthritis: Evidences From Collagen-Induced Arthritis and Clinical Samples. Publication Status: Online-Only, [RefSeq, PubMed]; Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0JN18;Q6P793", "ec_number_list": [ { "id": "5.3.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.1", "type": "external" }, { "id": "4.2.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.3.3", "type": "external" } ], "go_molecular_function": "GO:0004807 triose-phosphate isomerase activity;GO:0042803 protein homodimerization activity;GO:0031625 ubiquitin protein ligase binding;GO:0016853 isomerase activity;GO:0008929 methylglyoxal synthase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0019682 glyceraldehyde-3-phosphate metabolic process;GO:0019563 glycerol catabolic process;GO:0006094 gluconeogenesis;GO:0006006 glucose metabolic process;GO:0006096 glycolytic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P48500-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WVI4-1", "uniprot_id": [ { "id": "GCYA2_RAT", "url": "https://www.uniprot.org/uniprot/Q9WVI4", "type": "external" } ], "mass": 81787.0, "length": 730, "protein_name": "Guanylate cyclase soluble subunit alpha-2", "gene_name": "Gucy1a2", "organism": "Rat", "refseq_name": "guanylate cyclase soluble subunit alpha-2", "refseq_ac": [ { "id": "NP_076446", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076446", "type": "external" } ], "gene_names_uniprotkb": "Gucy1a2", "gene_names_refseq": "GCS-alpha-2; Gucy1a2", "protein_names_uniprotkb": "Guanylate cyclase soluble subunit alpha-2; 4.6.1.2; GCS-alpha-2", "protein_names_refseq": "guanylate cyclase 1, soluble, alpha 2; guanylate cyclase soluble subunit alpha-2; nitric oxide-sensitive; soluble guanylyl cyclase alpha2 subunit", "tax_id": 10116, "disease": "", "pathway": " (rno:66012); (R-RNO-445355)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11121588;18572161;19141686;22608751;22806360;23579428", "class_list": "", "function": "Alpha subunit of soluble guanylate cyclase (sGC), a central enzyme in nitric oxide (NO) signaling. Functions as the main intracellular receptor for NO. Upon NO binding, catalyzes the conversion of GTP to cyclic GMP (cGMP) and thereby transducing NO signal into a ubiquitous intracellular second messenger., [UniProtKB, PubMed]; Estradiol physiologically regulates sGC expression and activity in rat anterior pituitary gland., [RefSeq, PubMed]; Examine the involvement of soluble guanylate cyclase alpha(1) and alpha(2), and SK(Ca) channels in NANC relaxation of mouse distal colon., [RefSeq, PubMed]; Has guanylyl cyclase on binding to the beta-1 subunit., [UniProtKB, UniProtKB, UniProtKB]; In each gender group alpha1 and beta1-soluble guanylate cyclase was comparably and significantly increased but female rats produced significantly more cyclic guanosine monophosphate after treatment with the soluble guanylate cyclase stimulator., [RefSeq, PubMed]; Soluble guanylyl cyclase signal pathway is involved in the development of cocaine sensitization., [RefSeq, PubMed]; The effect of glucagon-like peptide-2 on the expression of the alpha1, alpha2, and beta1 subunits of soluble guanylyl cyclase, was studied., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q54A43", "ec_number_list": [ { "id": "4.6.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.2", "type": "external" } ], "go_molecular_function": "GO:0004383 guanylate cyclase activity;GO:0005525 GTP binding;GO:0044877 protein-containing complex binding;GO:0020037 heme binding", "go_cellular_component": "GO:0005829 cytosol;GO:0008074 guanylate cyclase complex, soluble", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0010750 positive regulation of nitric oxide mediated signal transduction;GO:0070482 response to oxygen levels", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9WVI4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43244-1", "uniprot_id": [ { "id": "MATR3_RAT", "url": "https://www.uniprot.org/uniprot/P43244", "type": "external" } ], "mass": 94447.0, "length": 845, "protein_name": "Matrin-3", "gene_name": "Matr3", "organism": "Rat", "refseq_name": "matrin-3", "refseq_ac": [ { "id": "NP_062022", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062022", "type": "external" } ], "gene_names_uniprotkb": "Matr3", "gene_names_refseq": "Matr3; P130/MAT3; snhg4", "protein_names_uniprotkb": "Matrin-3; Nuclear scaffold protein p130/MAT3", "protein_names_refseq": "matrin-3; nuclear scaffold protein P130/MAT3", "tax_id": 10116, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); amyotrophic lateral sclerosis type 21 (Disease Ontology:DOID:0060212); keratosis palmoplantaris striata 2 (Disease Ontology:DOID:0081109); Carvajal syndrome (Disease Ontology:DOID:0090128); arrhythmogenic right ventricular dysplasia 8 (Disease Ontology:DOID:0110076); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (rno:29150)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16641100;2033075;22673903", "class_list": "", "function": "May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs. May bind to specific miRNA hairpins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 38, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35833;Q5DVW1", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0035198 miRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016363 nuclear matrix", "go_biological_process": "GO:0003170 heart valve development;GO:0045087 innate immune response;GO:0010608 post-transcriptional regulation of gene expression;GO:0003281 ventricular septum development;GO:0002218 activation of innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P43244-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12368-1", "uniprot_id": [ { "id": "KAP2_RAT", "url": "https://www.uniprot.org/uniprot/P12368", "type": "external" } ], "mass": 45480.0, "length": 401, "protein_name": "cAMP-dependent protein kinase type II-alpha regulatory subunit", "gene_name": "Prkar2a", "organism": "Rat", "refseq_name": "cAMP-dependent protein kinase type II-alpha regulatory subunit", "refseq_ac": [ { "id": "NP_062137", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062137", "type": "external" } ], "gene_names_uniprotkb": "Prkar2a", "gene_names_refseq": "Prkar2a", "protein_names_uniprotkb": "cAMP-dependent protein kinase type II-alpha regulatory subunit", "protein_names_refseq": "cAMP-dependent protein kinase type II-alpha regulatory subunit; protein kinase cAMP-dependent type 2 regulatory subunit alpha; protein kinase, cAMP dependent regulatory, type II alpha; protein kinase, cAMP-dependent, regulatory subunit type II alpha; protein kinase, cAMP-dependent, regulatory, type 2, alpha", "tax_id": 10116, "disease": "cognitive disorder (Disease Ontology:DOID:1561); blood platelet disease (Disease Ontology:DOID:2218); middle cerebral artery infarction (Disease Ontology:DOID:3525); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); congestive heart failure (Disease Ontology:DOID:6000); ulcerative colitis (Disease Ontology:DOID:8577); irritable bowel syndrome (Disease Ontology:DOID:9778)", "pathway": " (rno:29699); (R-RNO-163615); (R-RNO-164378); (R-RNO-180024); (R-RNO-432040); (R-RNO-442720); (R-RNO-5610787); (R-RNO-9634597); (R-RNO-983231); (R-RNO-9856530)", "pathway_count": 10, "publication_count": 5, "publication_id_list": "16641100;17827149;22673903;29615473;3037538", "class_list": "", "function": "RII phosphorylation precedes cAMP binding and controls the inactivation by modulating the reassociation involving the coordinated action of phosphodiesterases and phosphatases., [RefSeq, PubMed]; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3V8Q6;Q8K1M2", "ec_number_list": [], "go_molecular_function": "GO:0031698 beta-2 adrenergic receptor binding;GO:0034236 protein kinase A catalytic subunit binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0004862 cAMP-dependent protein kinase inhibitor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:2000480 negative regulation of cAMP-dependent protein kinase activity;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0050804 modulation of chemical synaptic transmission;GO:1903538 regulation of meiotic cell cycle process involved in oocyte maturation;GO:0045859 regulation of protein kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P12368-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V8K1-1", "uniprot_id": [ { "id": "STEA4_RAT", "url": "https://www.uniprot.org/uniprot/Q4V8K1", "type": "external" } ], "mass": 52765.0, "length": 470, "protein_name": "Metalloreductase STEAP4", "gene_name": "Steap4", "organism": "Rat", "refseq_name": "metalloreductase STEAP4", "refseq_ac": [ { "id": "NP_001037730", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001037730", "type": "external" } ], "gene_names_uniprotkb": "Steap4", "gene_names_refseq": "Steap4", "protein_names_uniprotkb": "Metalloreductase STEAP4; 1.16.1.-; Six-transmembrane epithelial antigen of prostate 4", "protein_names_refseq": "Ab1-219; STEAP family member 4; metalloreductase STEAP4; six-transmembrane epithelial antigen of prostate 4", "tax_id": 10116, "disease": "", "pathway": " (rno:499991); (R-RNO-917977)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21454685;23733181;34583195", "class_list": "", "function": "Data suggest that Steap4 utilizes an interdomain flavin-binding site to shuttle electrons between the oxidoreductase and transmembrane domains., [RefSeq, PubMed]; Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane. Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (PubMed:23733181). Can also reduce Cu(2+) to Cu(1+) (PubMed:23733181). Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin-resistance (By similarity). Involved in inflammatory arthritis, through the regulation of inflammatory cytokines (By similarity). Inhibits anchorage-independent cell proliferation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Overexpressing STAMP2 attenuates diabetic renal injuries via upregulating autophagy in diabetic rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.16.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.1.-", "type": "external" } ], "go_molecular_function": "GO:0009055 electron transfer activity;GO:0046872 metal ion binding;GO:0071949 FAD binding;GO:0020037 heme binding;GO:0008823 cupric reductase (NADH) activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0031901 early endosome membrane", "go_biological_process": "GO:0045444 fat cell differentiation;GO:0070207 protein homotrimerization;GO:0015677 copper ion import;GO:0033212 iron import into cell;GO:0006826 iron ion transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q4V8K1-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTW1-1", "uniprot_id": [ { "id": "GRIP2_RAT", "url": "https://www.uniprot.org/uniprot/Q9WTW1", "type": "external" } ], "mass": 112488.0, "length": 1043, "protein_name": "Glutamate receptor-interacting protein 2", "gene_name": "Grip2", "organism": "Rat", "refseq_name": "glutamate receptor-interacting protein 2", "refseq_ac": [ { "id": "NP_612544", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612544", "type": "external" } ], "gene_names_uniprotkb": "Grip2", "gene_names_refseq": "Abp; Grip2", "protein_names_uniprotkb": "Glutamate receptor-interacting protein 2; AMPA receptor-interacting protein GRIP2; GRIP-2", "protein_names_refseq": "AMPA receptor binding protein; AMPA receptor-interacting protein GRIP2; GRIP-2; glutamate receptor-interacting protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:171571); (R-RNO-416993)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10197531;10414981;10436050;10896157;11978826;12458226;20083202;20956289;22673903;9768844", "class_list": "", "function": "GRIP1 and 2 regulate activity-dependent AMPA receptor recycling via exocyst complex interactions., [RefSeq, PubMed]; May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons., [UniProtKB]; Postsynaptic palmitoylated ABP induces pre and postsynaptic changes that are dependent on palmitoylation and likely achieved through ABP association with a multi-molecular cell surface signaling complex., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O88961;Q9WU36", "ec_number_list": [], "go_molecular_function": "GO:0035254 glutamate receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane;GO:0007219 Notch signaling pathway;GO:0045777 positive regulation of blood pressure;GO:2000463 positive regulation of excitatory postsynaptic potential;GO:0014824 artery smooth muscle contraction", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9WTW1-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZXS4-1", "uniprot_id": [ { "id": "LRC39_RAT", "url": "https://www.uniprot.org/uniprot/D3ZXS4", "type": "external" } ], "mass": 38716.0, "length": 334, "protein_name": "Leucine-rich repeat-containing protein 39", "gene_name": "Lrrc39", "organism": "Rat", "refseq_name": "leucine-rich repeat-containing protein 39", "refseq_ac": [ { "id": "NP_001103107", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103107", "type": "external" } ], "gene_names_uniprotkb": "Lrrc39", "gene_names_refseq": "Lrrc39", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 39; Myomasp; Myosin-interacting M-band-associated stress-responsive protein", "protein_names_refseq": "leucine-rich repeat-containing protein 39; myomasp; myosin-interacting M-band-associated stress-responsive protein", "tax_id": 10116, "disease": "", "pathway": " (rno:691307)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "20847312", "class_list": "", "function": "Component of the sarcomeric M-band which plays a role in myocyte response to biomechanical stress. May regulate expression of other M-band proteins via an SRF-dependent pathway. Important for normal contractile function in heart., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Reveal myomasp/LRRC39 as a previously unrecognized component of an M-band-associated signaling pathway that regulates cardiomyocyte gene expression in response to biomechanical stress., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0031430 M band", "go_biological_process": "GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZXS4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZZW6-1", "uniprot_id": [ { "id": "HILS1_RAT", "url": "https://www.uniprot.org/uniprot/D3ZZW6", "type": "external" } ], "mass": 18617.0, "length": 169, "protein_name": "Histone H1.9", "gene_name": "H1-9", "organism": "Rat", "refseq_name": "histone H1.9", "refseq_ac": [ { "id": "NP_001103035", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103035", "type": "external" } ], "gene_names_uniprotkb": "H1-9; H1-9p; H1f9; Hils1", "gene_names_refseq": "H1-9; Hils1", "protein_names_uniprotkb": "Histone H1.9; Spermatid-specific linker histone H1-like protein", "protein_names_refseq": "histone H1-like protein in spermatids 1; histone H1.9; spermatid-specific linker histone H1-like protein", "tax_id": 10116, "disease": "", "pathway": " (rno:690026)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22673903;26257145;30068355", "class_list": "", "function": "DNA-binding protein that may be implicated in chromatin remodeling and/or transcriptional regulation during spermiogenesis, the process of spermatid maturation into spermatozoa., [UniProtKB, UniProtKB]; Immunofluorescence studies demonstrate the presence of linker histone HILS1 and HILS1Y78p during different steps of spermiogenesis from early elongating to condensing spermatids., [RefSeq, PubMed]; Results show that HILS1 possesses significantly lower alpha-helicity compared to other linker histones but also show that HILS1 is a poor condenser of chromatin which demonstrate the idea that this particular linker histone variant may have distinct role in histone to protamine replacement. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003676 nucleic acid binding;GO:0003690 double-stranded DNA binding;GO:0042393 histone binding;GO:0031492 nucleosomal DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0001673 male germ cell nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis;GO:0006334 nucleosome assembly;GO:0007281 germ cell development;GO:0030261 chromosome condensation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D3ZZW6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62910-1", "uniprot_id": [ { "id": "SYNJ1_RAT", "url": "https://www.uniprot.org/uniprot/Q62910", "type": "external" } ], "mass": 172881.0, "length": 1574, "protein_name": "Polyphosphatidylinositol phosphatase SYNJ1", "gene_name": "Synj1", "organism": "Rat", "refseq_name": "synaptojanin-1 isoform 2", "refseq_ac": [ { "id": "NP_001401979", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001401979", "type": "external" } ], "gene_names_uniprotkb": "Synj1", "gene_names_refseq": "Synj1", "protein_names_uniprotkb": "Polyphosphatidylinositol phosphatase SYNJ1; 3.1.3.-; 3.1.3.95; Inositol polyphosphate-5-phosphatase G; Phosphatidylinositol-3,5-bisphosphate 3-phosphatase SYNJ1; Phosphatidylinositol-4-phosphatase SYNJ1; Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1; Synaptojanin-1", "protein_names_refseq": "synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1; synaptojanin-1 isoform 2", "tax_id": 10116, "disease": "early-onset Parkinson's disease (Disease Ontology:DOID:0060894); Parkinson's disease 20 (Disease Ontology:DOID:0060898); developmental and epileptic encephalopathy 53 (Disease Ontology:DOID:0080464); Down syndrome (Disease Ontology:DOID:14250); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (rno:85238); (R-RNO-1660499); (R-RNO-1855183); (R-RNO-1855204); (R-RNO-8856828)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "17257598;18683930;22673903;8552192;8798761;9238017;9341169;9428629;9710239", "class_list": "", "function": "Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate. Has a role in clathrin-mediated endocytosis. Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Phosphatase that hydrolyzes phosphate groups from the inositol ring of phosphoinositides and inositol phosphates, in a domain-specific manner (PubMed:8552192, PubMed:9710239). The 5-PPase domain catalyzes removal of the 5-phosphate from substrates such as phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2), phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3), inositol-1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol-1,3,4,5-tetrakisphosphate (Ins(1,3,4,5)P4) (PubMed:8552192, PubMed:9710239). The SAC domain hydrolyzes phosphates at the 3- and 4-positions of the inositol ring, targeting phosphatidylinositol-3-phosphate (PI(3)P), phosphatidylinositol-4-phosphate (PI(4)P), and phosphatidylinositol-3,5-bisphosphate (PI(3,5)P2) (By similarity). Plays a role in the phosphatidylinositol metabolic process during an unconventional endocytic mechanism, the ultrafast endocytosis where it participates in the rapide neck formation of the newly generated synaptic vesicle through its phosphoinositide 5-phosphatase activity (By similarity). Also, participates in the clathrin uncoating of synaptc vesicle formed via budding from synaptic endosomes after ultrafast endocytosis through combined activity of its phosphatase domains (PubMed:9428629). Additionally, regulates actin filament rearrangement by hydrolyzing PIP2 bound to actin regulatory proteins (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O89092;Q62911;Q810Z8", "ec_number_list": [ { "id": "3.1.3.95", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.95", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.64", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.64", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0017124 SH3 domain binding;GO:0044877 protein-containing complex binding;GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity;GO:1990175 EH domain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0043195 terminal bouton;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0031161 phosphatidylinositol catabolic process;GO:0007612 learning;GO:0032526 response to retinoic acid;GO:0034097 response to cytokine;GO:0048260 positive regulation of receptor-mediated endocytosis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q62910-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4AE48-1", "uniprot_id": [ { "id": "MIDN_RAT", "url": "https://www.uniprot.org/uniprot/D4AE48", "type": "external" } ], "mass": 53679.0, "length": 505, "protein_name": "Midnolin", "gene_name": "Midn", "organism": "Rat", "refseq_name": "midnolin isoform 3", "refseq_ac": [ { "id": "NP_001178506", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178506", "type": "external" } ], "gene_names_uniprotkb": "Midn", "gene_names_refseq": "Midn", "protein_names_uniprotkb": "Midnolin; Midbrain nucleolar protein", "protein_names_refseq": "midbrain nucleolar protein; midnolin isoform 3", "tax_id": 10116, "disease": "", "pathway": " (rno:314623)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "24187134;28724963;29311479", "class_list": "", "function": "Facilitates the ubiquitin-independent proteasomal degradation of stimulus-induced transcription factors such as FOSB, EGR1, NR4A1, and IRF4 to the proteasome for degradation (By similarity). Promotes also the degradation of other substrates such as CBX4 (By similarity). Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion (PubMed:24187134)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; MIDN promotes the expression of parkin E3 ubiquitin ligase, and that MIDN loss can trigger Parkinson's disease-related pathogenic mechanisms. Publication Status: Online-Only, [RefSeq, PubMed]; Midnolin plays a role in cellular signaling of adult tissues and regulates glucokinase enzyme activity in pancreatic beta cells, [RefSeq, PubMed]; These findings indicate that MIDN regulates the expression of a wide variety of genes, including multiple Parkinson's Disease causative genes and is associated with Parkinson's Disease onset., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019900 kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0046676 negative regulation of insulin secretion;GO:0033132 negative regulation of glucokinase activity;GO:0010499 proteasomal ubiquitin-independent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D4AE48-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PTA2-1", "uniprot_id": [ { "id": "TRPM2_RAT", "url": "https://www.uniprot.org/uniprot/E9PTA2", "type": "external" } ], "mass": 172259.0, "length": 1507, "protein_name": "Transient receptor potential cation channel subfamily M member 2", "gene_name": "Trpm2", "organism": "Rat", "refseq_name": "transient receptor potential cation channel subfamily M member 2", "refseq_ac": [ { "id": "NP_001011559", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011559", "type": "external" } ], "gene_names_uniprotkb": "Trpm2", "gene_names_refseq": "Trpm2-predicted; Trpm2", "protein_names_uniprotkb": "Transient receptor potential cation channel subfamily M member 2", "protein_names_refseq": "transient receptor potential cation channel subfamily M member 2; transient receptor potential melastatin family 2", "tax_id": 10116, "disease": "transient cerebral ischemia (Disease Ontology:DOID:224)", "pathway": " (rno:294329); (R-RNO-3295583); (R-RNO-6798695)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "11804595;16104849;16260005;16601673;16651700;19454650;22673903;25562606;31120580;32294037;37215981;37300693;37454827", "class_list": "", "function": "Activation of TRPM2, functionally expressed in primary cultures of rat striatum, contributes to Abeta- and oxidative stress-induced striatal cell death, [RefSeq, PubMed]; Nonselective, voltage-independent cation channel that mediates Na(+) and Ca(2+) influx, leading to increased cytoplasmic Ca(2+) levels (PubMed:11804595, PubMed:16260005, PubMed:16601673, PubMed:16651700, PubMed:19454650). Functions as a ligand-gated ion channel gated by intracellular adenosine diphosphate ribose (ADP-ribose), Ca(2+), warm temperature, and oxidative stress. The precise physiological activators are under debate; the true, physiological activators may be ADP-ribose and ADP-ribose-2'-phosphate (By similarity). Binding of ADP-ribose to the cytoplasmic Nudix domain causes a conformation change; the channel is primed but still requires Ca(2+) binding to trigger channel opening. Extracellular Ca(2+) passes through the channel and increases channel activity (By similarity). Also contributes to Ca(2+) release from intracellular stores in response to ADP-ribose (PubMed:19454650). Plays a role in numerous processes that involve signaling via intracellular Ca(2+) levels (Probable). Besides, mediates the release of lysosomal Zn(2+) stores in response to reactive oxygen species, leading to increased cytosolic Zn(2+) levels (PubMed:25562606). Plays a role in insulin secretion, a process that requires increased cytoplasmic Ca(2+) levels (PubMed:16601673). Required for normal IFNG and cytokine secretion and normal innate immune immunity in response to bacterial infection. Required for normal phagocytosis and cytokine release by macrophages exposed to zymosan (in vitro). Plays a role in dendritic cell differentiation and maturation, and in dendritic cell chemotaxis via its role in regulating cytoplasmic Ca(2+) levels (By similarity). Plays a role in the regulation of the reorganization of the actin cytoskeleton and filopodia formation in response to reactive oxygen species via its function in increasing cytoplasmic Ca(2+) and Zn(2+) levels (By similarity). Confers susceptibility to cell death following oxidative stress (PubMed:11804595, PubMed:16651700, PubMed:19454650, PubMed:25562606)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Over-activation of TRPM2 ion channel accelerates blood-spinal cord barrier destruction in diabetes combined with spinal cord injury rat. Publication Status: Online-Only, [RefSeq, PubMed]; Pharmacological Inhibition of Transient Receptor Potential Melastatin 2 (TRPM2) Channels Attenuates Diabetes-induced Cognitive Deficits in Rats: A Mechanistic Study., [RefSeq, PubMed]; TRPM2 may be involved in high fructose corn syrup-induced anxiety-like behavior in adult male rats. Publication Status: Online-Only, [RefSeq, PubMed]; TRPM2 participates in the transformation of acute pain to chronic pain during injury-induced neuropathic pain, [RefSeq, PubMed]; Transient receptor potential M2 channel in the hypothalamic preoptic area and its impact on thermoregulation during menopause., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2PH54;Q5G856", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005261 monoatomic cation channel activity;GO:0005272 sodium channel activity;GO:0015278 intracellularly gated calcium channel activity;GO:0005384 manganese ion transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043025 neuronal cell body;GO:0043204 perikaryon;GO:0005764 lysosome;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0071577 zinc ion transmembrane transport;GO:0001659 temperature homeostasis;GO:0014074 response to purine-containing compound;GO:0032024 positive regulation of insulin secretion;GO:0032956 regulation of actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "E9PTA2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O55207-1", "uniprot_id": [ { "id": "SYNJ2_RAT", "url": "https://www.uniprot.org/uniprot/O55207", "type": "external" } ], "mass": 165264.0, "length": 1496, "protein_name": "Polyphosphatidylinositol phosphatase SYNJ2", "gene_name": "Synj2", "organism": "Rat", "refseq_name": "synaptojanin-2 isoform 1", "refseq_ac": [ { "id": "NP_001106842", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106842", "type": "external" } ], "gene_names_uniprotkb": "Synj2", "gene_names_refseq": "Synj2", "protein_names_uniprotkb": "Polyphosphatidylinositol phosphatase SYNJ2; 3.1.3.-; 3.1.3.95; Phosphatidylinositol-3,5-bisphosphate 3-phosphatase SYNJ2; Phosphatidylinositol-4-phosphatase SYNJ2; Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2; Synaptojanin-2", "protein_names_refseq": "synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2; synaptojanin-2 isoform 1", "tax_id": 10116, "disease": "early-onset Parkinson's disease (Disease Ontology:DOID:0060894); Down syndrome (Disease Ontology:DOID:14250); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (rno:84018); (R-RNO-1660499); (R-RNO-8856828)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10357812;11498538;38442648;9388224", "class_list": "", "function": "Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Phosphatase that hydrolyzes phosphate groups from the inositol ring of phosphoinositides and inositol phosphates, in a domain-specific manner (PubMed:11498538, PubMed:38442648, PubMed:9388224). The 5-PPase domain catalyzes removal of the 5-phosphate from substrates such as phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2), phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3), inositol-1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol-1,3,4,5-tetrakisphosphate (Ins(1,3,4,5)P4) (PubMed:38442648, PubMed:9388224). The SAC domain hydrolyzes phosphates at the 3- and 4-positions of the inositol ring, targeting phosphatidylinositol-3-phosphate (PI(3)P), phosphatidylinositol-4-phosphate (PI(4)P), and phosphatidylinositol-3,5-bisphosphate (PI(3,5)P2) (PubMed:11498538, PubMed:38442648). Plays a role in the phosphatidylinositol metabolic process during the early stage of clathrin-coated-pit formation (By similarity). During EGF activation, plays a role in receptor-mediated endocytosis (RME) by converting PtdIns(4,5)P2 to PtdIns(4)P through the H2O2-dependent oxidation of the 4-phosphatase domain (PubMed:38442648). May play a role in tumor cell invadopodia formation (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91ZD8;Q91ZD9", "ec_number_list": [ { "id": "3.1.3.95", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.95", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.64", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.64", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0017124 SH3 domain binding;GO:0030165 PDZ domain binding;GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity;GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0016020 membrane;GO:0043679 axon terminus;GO:0045121 membrane raft", "go_biological_process": "GO:0006898 receptor-mediated endocytosis;GO:0048268 clathrin coat assembly;GO:0046856 phosphatidylinositol dephosphorylation;GO:0048488 synaptic vesicle endocytosis;GO:0071545 inositol phosphate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O55207-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q53UA7-1", "uniprot_id": [ { "id": "TAOK3_RAT", "url": "https://www.uniprot.org/uniprot/Q53UA7", "type": "external" } ], "mass": 105474.0, "length": 898, "protein_name": "Serine/threonine-protein kinase TAO3", "gene_name": "Taok3", "organism": "Rat", "refseq_name": "serine/threonine-protein kinase TAO3", "refseq_ac": [ { "id": "NP_001019425", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019425", "type": "external" } ], "gene_names_uniprotkb": "Taok3; Arg357; Jik", "gene_names_refseq": "JIK; Taok3", "protein_names_uniprotkb": "Serine/threonine-protein kinase TAO3; 2.7.11.1; Axotomy-related gene 357 protein; JNK/SAPK-inhibitory kinase; Jun kinase-inhibitory kinase; Thousand and one amino acid protein 3", "protein_names_refseq": "JNK/SAPK-inhibitory kinase; axotomy-related gene 357 protein; jun kinase-inhibitory kinase; serine/threonine-protein kinase TAO3; thousand and one amino acid protein 3", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515); cancer (Disease Ontology:DOID:162); central nervous system disease (Disease Ontology:DOID:331)", "pathway": " (rno:304530); (R-RNO-9013149); (R-RNO-9013404); (R-RNO-9013423)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "16092929;22673903", "class_list": "", "function": "JIK may contribute to axotomy-induced retinal ganglion cell death by up-regulating the expression of BH3-only protein Erratum:[J Neurochem. 2007 Jun;101(6):1723], [RefSeq, PubMed]; Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of the MAPK8/JNK cascade and diminishes its activation in response to epidermal growth factor (EGF). Positively regulates canonical T cell receptor (TCR) signaling by preventing early PTPN6/SHP1-mediated inactivation of LCK, ensuring sustained TCR signaling that is required for optimal activation and differentiation of T cells. Phosphorylates PTPN6/SHP1 on 'Thr-396', leading to its polyubiquitination and subsequent proteasomal degradation. Required for cell surface expression of metalloprotease ADAM10 on type 1 transitional B cells which is necessary for their NOTCH-mediated development into marginal zone B cells. Also required for the NOTCH-mediated terminal differentiation of splenic conventional type 2 dendritic cells. Positively regulates osteoblast differentiation by acting as an upstream activator of the JNK pathway. Promotes JNK signaling in hepatocytes and positively regulates hepatocyte lipid storage by inhibiting beta-oxidation and triacylglycerol secretion while enhancing lipid synthesis. Restricts age-associated inflammation by negatively regulating differentiation of macrophages and their production of pro-inflammatory cytokines. Plays a role in negatively regulating the abundance of regulatory T cells in white adipose tissue., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "1.6.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.-", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0016740 transferase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0005886 plasma membrane;GO:0045121 membrane raft", "go_biological_process": "GO:0006281 DNA repair;GO:0006468 protein phosphorylation;GO:0046330 positive regulation of JNK cascade;GO:0000165 MAPK cascade;GO:0048812 neuron projection morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q53UA7-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03410-1", "uniprot_id": [ { "id": "SYCP1_RAT", "url": "https://www.uniprot.org/uniprot/Q03410", "type": "external" } ], "mass": 116511.0, "length": 997, "protein_name": "Synaptonemal complex protein 1", "gene_name": "Sycp1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Sycp1; Scp1", "gene_names_refseq": "", "protein_names_uniprotkb": "Synaptonemal complex protein 1; SCP-1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:25276)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "1464329;22673903", "class_list": "", "function": "Major component of the transverse filaments of synaptonemal complexes, formed between homologous chromosomes during meiotic prophase (PubMed:1464329). Required for normal assembly of the central element of the synaptonemal complexes. Required for normal centromere pairing during meiosis. Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0000801 central element;GO:0000794 condensed nuclear chromosome;GO:0000775 chromosome, centromeric region;GO:0001673 male germ cell nucleus;GO:0005694 chromosome", "go_biological_process": "GO:0007283 spermatogenesis;GO:0051289 protein homotetramerization;GO:0051301 cell division;GO:0032880 regulation of protein localization;GO:0007130 synaptonemal complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q03410-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QWN8-1", "uniprot_id": [ { "id": "SPTN2_RAT", "url": "https://www.uniprot.org/uniprot/Q9QWN8", "type": "external" } ], "mass": 271064.0, "length": 2388, "protein_name": "Spectrin beta chain, non-erythrocytic 2", "gene_name": "Sptbn2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Sptbn2; Spnb3", "gene_names_refseq": "", "protein_names_uniprotkb": "Spectrin beta chain, non-erythrocytic 2; Beta SpIII sigma 1; Beta-III spectrin; Glutamate transporter EAAT4-associated protein 41; SPNB-3; Spectrin-like protein GTRAP41", "protein_names_refseq": "", "tax_id": 10116, "disease": "spinocerebellar ataxia 5 (Disease Ontology:DOID:0050882); autosomal recessive spinocerebellar ataxia 14 (Disease Ontology:DOID:0080058)", "pathway": " (rno:29211); (R-RNO-2132295); (R-RNO-375165); (R-RNO-445095); (R-RNO-5673001); (R-RNO-6807878)", "pathway_count": 6, "publication_count": 6, "publication_id_list": "11242047;15340146;16641100;22673903;9675416;9704016", "class_list": "", "function": "Probably plays an important role in neuronal membrane skeleton., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88197;Q9ES68", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005543 phospholipid binding;GO:0051015 actin filament binding;GO:0098918 structural constituent of synapse;GO:0099186 structural constituent of postsynapse", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005829 cytosol", "go_biological_process": "GO:0030534 adult behavior;GO:0030036 actin cytoskeleton organization;GO:0035264 multicellular organism growth;GO:0007416 synapse assembly;GO:0071361 cellular response to ethanol", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9QWN8-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35952-1", "uniprot_id": [ { "id": "LDLR_RAT", "url": "https://www.uniprot.org/uniprot/P35952", "type": "external" } ], "mass": 96622.0, "length": 879, "protein_name": "Low-density lipoprotein receptor", "gene_name": "Ldlr", "organism": "Rat", "refseq_name": "low-density lipoprotein receptor precursor", "refseq_ac": [ { "id": "NP_786938", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786938", "type": "external" } ], "gene_names_uniprotkb": "Ldlr", "gene_names_refseq": "LDLRA; Ldlr", "protein_names_uniprotkb": "Low-density lipoprotein receptor; LDL receptor", "protein_names_refseq": "LDL receptor; low-density lipoprotein receptor precursor", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); aortic atherosclerosis (Disease Ontology:DOID:10230); Alzheimer's disease (Disease Ontology:DOID:10652); familial hyperlipidemia (Disease Ontology:DOID:1168); migraine without aura (Disease Ontology:DOID:12783); familial hypercholesterolemia (Disease Ontology:DOID:13810); hepatitis C (Disease Ontology:DOID:1883); atherosclerosis (Disease Ontology:DOID:1936); arteriosclerosis (Disease Ontology:DOID:2349); xanthomatosis (Disease Ontology:DOID:3345); systemic lupus erythematosus (Disease Ontology:DOID:9074); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (rno:300438); (R-RNO-8856825); (R-RNO-8856828); (R-RNO-8964026); (R-RNO-8964038)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "16641100;21454685;2922268;29459263;29938676;30483910", "class_list": "", "function": "Binds low density lipoprotein /LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Forms a ternary complex with PGRMC1 and TMEM97 receptors which increases LDLR-mediated LDL internalization., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Deficiency of either Ldlr or Apoe genes induced hyperlipidemia, which promoted endothelial inflammation and led to typical atherosclerosis in rats on normal or Western diets., [RefSeq, PubMed]; This suggests that overexpression of HNF1alpha gene in liver of lipectomized rats can lead to overproduction of PCSK9. In conclusion, up-regulation of PCSK9, due to overexpression of HNF1alpha gene in liver of lipectomized rats and subsequently increase in circulating PCSK9 concentration lead to decrease in liver LDL-R level., [RefSeq, PubMed]; Up-regulation of intestinal gene expression of LDL-R and PCSK9 following voluntary wheel running, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0002020 protease binding;GO:0042802 identical protein binding;GO:0001540 amyloid-beta binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005768 endosome;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit", "go_biological_process": "GO:1903979 negative regulation of microglial cell activation;GO:1905167 positive regulation of lysosomal protein catabolic process;GO:0001523 retinoid metabolic process;GO:0006629 lipid metabolic process;GO:0006897 endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P35952-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24054-1", "uniprot_id": [ { "id": "SPRL1_RAT", "url": "https://www.uniprot.org/uniprot/P24054", "type": "external" } ], "mass": 70634.0, "length": 634, "protein_name": "SPARC-like protein 1", "gene_name": "Sparcl1", "organism": "Rat", "refseq_name": "SPARC-like protein 1 precursor", "refseq_ac": [ { "id": "NP_037078", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037078", "type": "external" } ], "gene_names_uniprotkb": "Sparcl1; Sc1", "gene_names_refseq": "Ecm2; Sc1; Sparcl1", "protein_names_uniprotkb": "SPARC-like protein 1; Matrix glycoprotein Sc1", "protein_names_refseq": "Extracellular matrix protein 2; SPARC-like 1 (hevin); SPARC-like 1 (mast9, hevin); SPARC-like protein 1 precursor; SPARC-like protein 1; matrix glycoprotein Sc1", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); neuronal ceroid lipofuscinosis 13 (Disease Ontology:DOID:0110727)", "pathway": " (rno:25434); (R-RNO-381426); (R-RNO-8957275)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "1690015;18335312;22588386;22673903;35820448;37534667", "class_list": "", "function": "MicroRNA-105-5p protects against chondrocyte injury, extracellular matrix degradation, and osteoarthritis progression by targeting SPARCL1., [RefSeq, PubMed]; SC1 appears to characterize damaged striatal white matter damage after multiple types of injury, [RefSeq, PubMed]; These findings indicate that the pattern of SC1 localization coincides with synaptogenesis during rat postnatal development., [RefSeq, PubMed]; Upregulation of Hevin contributes to postoperative pain hypersensitivity by inducing neurexin1beta/neuroligin1-mediated synaptic targeting of GluA1-containing AMPA receptors in rat dorsal horn., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0098965 extracellular matrix of synaptic cleft", "go_biological_process": "GO:0007165 signal transduction;GO:0099560 synaptic membrane adhesion;GO:0050807 regulation of synapse organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P24054-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35814-1", "uniprot_id": [ { "id": "STIP1_RAT", "url": "https://www.uniprot.org/uniprot/O35814", "type": "external" } ], "mass": 62570.0, "length": 543, "protein_name": "Stress-induced-phosphoprotein 1", "gene_name": "Stip1", "organism": "Rat", "refseq_name": "stress-induced-phosphoprotein 1", "refseq_ac": [ { "id": "NP_620266", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620266", "type": "external" } ], "gene_names_uniprotkb": "Stip1; Hop", "gene_names_refseq": "Stip1", "protein_names_uniprotkb": "Stress-induced-phosphoprotein 1; Hop; Hsc70/Hsp90-organizing protein; STI1", "protein_names_refseq": "STI1; hop; hsc70/Hsp90-organizing protein; stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein); stress-induced-phosphoprotein 1", "tax_id": 10116, "disease": "childhood-onset asthma (Disease Ontology:DOID:0080815)", "pathway": " (rno:192277); (R-RNO-3371497); (R-RNO-9696273)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "17329112;29393594;34734476;37904692;9528774", "class_list": "", "function": "Acts as a co-chaperone for HSP90AA1 (By similarity). Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (PubMed:9528774)., [UniProtKB, UniProtKB, PubMed]; Acts as a co-chaperone for HSP90AA1. Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; STI1 interaction with PrP(C) affects short-term memory formation and long-term memory consolidation, [RefSeq, PubMed]; Stress-induced phosphoprotein 1 restrains spinal cord ischaemia-reperfusion injury by modulating NF-kappaB signalling., [RefSeq, PubMed]; The potential roles of stress-induced phosphoprotein 1 and connexin 43 in rats with reperfusion arrhythmia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051087 protein-folding chaperone binding;GO:0051879 Hsp90 protein binding;GO:0030544 Hsp70 protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0032991 protein-containing complex;GO:0101031 protein folding chaperone complex;GO:0120293 dynein axonemal particle", "go_biological_process": "GO:0098761 cellular response to interleukin-7", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O35814-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70608-1", "uniprot_id": [ { "id": "SYCP2_RAT", "url": "https://www.uniprot.org/uniprot/O70608", "type": "external" } ], "mass": 172593.0, "length": 1505, "protein_name": "Synaptonemal complex protein 2", "gene_name": "Sycp2", "organism": "Rat", "refseq_name": "synaptonemal complex protein 2", "refseq_ac": [ { "id": "NP_570091", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_570091", "type": "external" } ], "gene_names_uniprotkb": "Sycp2; Scp2", "gene_names_refseq": "Sycp2", "protein_names_uniprotkb": "Synaptonemal complex protein 2; SCP-2; Synaptonemal complex lateral element protein; rnSCP2", "protein_names_refseq": "SCP-2; rnSCP2; synaptonemal complex lateral element protein; synaptonemal complex protein 2", "tax_id": 10116, "disease": "spermatogenic failure 1 (Disease Ontology:DOID:0070188)", "pathway": " (rno:83820)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10652260;22673903;9592139;9933407", "class_list": "", "function": "Major component of the axial/lateral elements of synaptonemal complexes (SCS) during meiotic prophase (PubMed:9592139, PubMed:9933407). Plays a role in the assembly of synaptonemal complexes. Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility. Required for insertion of SYCP3 into synaptonemal complexes. May be involved in the organization of chromatin by temporarily binding to DNA scaffold attachment regions. Requires SYCP3, but not SYCP1, in order to be incorporated into the axial/lateral elements., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 32, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0000779 condensed chromosome, centromeric region;GO:0000800 lateral element;GO:0000795 synaptonemal complex;GO:0005634 nucleus;GO:0005694 chromosome", "go_biological_process": "GO:0009566 fertilization;GO:0043066 negative regulation of apoptotic process;GO:0051301 cell division;GO:0009887 animal organ morphogenesis;GO:0007143 female meiotic nuclear division", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O70608-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C627-1", "uniprot_id": [ { "id": "UBX2B_RAT", "url": "https://www.uniprot.org/uniprot/P0C627", "type": "external" } ], "mass": 37075.0, "length": 331, "protein_name": "UBX domain-containing protein 2B", "gene_name": "Ubxn2b", "organism": "Rat", "refseq_name": "UBX domain-containing protein 2B", "refseq_ac": [ { "id": "NP_001101375", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101375", "type": "external" } ], "gene_names_uniprotkb": "Ubxn2b; ENSRNOG00000064562", "gene_names_refseq": "RGD1308557; Ubxn2b", "protein_names_uniprotkb": "UBX domain-containing protein 2B; NSFL1 cofactor p37; p97 cofactor p37", "protein_names_refseq": "NSFL1 cofactor p37; UBX domain-containing protein 2B; p97 cofactor p37", "tax_id": 10116, "disease": "", "pathway": " (rno:312965)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17141156;22673903", "class_list": "", "function": "Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required, but not its deubiquitinating activity. Together with NSFL1C/p47, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0031616 spindle pole centrosome", "go_biological_process": "GO:0031468 nuclear membrane reassembly;GO:0043335 protein unfolding;GO:0000045 autophagosome assembly;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0061025 membrane fusion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P0C627-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30936-1", "uniprot_id": [ { "id": "SSR3_RAT", "url": "https://www.uniprot.org/uniprot/P30936", "type": "external" } ], "mass": 47151.0, "length": 428, "protein_name": "Somatostatin receptor type 3", "gene_name": "Sstr3", "organism": "Rat", "refseq_name": "somatostatin receptor type 3", "refseq_ac": [ { "id": "NP_598206", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598206", "type": "external" } ], "gene_names_uniprotkb": "Sstr3", "gene_names_refseq": "SSTR; Smstr28; Sstr3", "protein_names_uniprotkb": "Somatostatin receptor type 3; SS-3-R; SS3-R; SS3R; SSR-28", "protein_names_refseq": "SS-3-R; SS3-R; SS3R; SSR-28; somatostatin receptor 28; somatostatin receptor subtype 3; somatostatin receptor type 3", "tax_id": 10116, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (rno:171044); (R-RNO-375276); (R-RNO-418594); (R-RNO-5620922)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "11087995;11134004;1279674;25926390;28176050;29522573;9295322", "class_list": "", "function": "All SSTR1-5 proteins were observed at embryonal day 10 and increased with time in major structures, but the localization varied between the different subtypes. SSTR3-4 was co-localized with insulin and pancreatic polypeptide., [RefSeq, PubMed]; In the jejunums of Cryptosporidium-parvum-infected rats, daily octreotide therapy increased mRNA levels of SSTR3 on day 50 post-infection. Specific SSTRs may regulate the inflammatory pathway in the rat intestinal inflammation model. Erratum:[PLoS One. 2018 May 24;13(5):e0198377. doi: 10.1371/journal.pone.0198377. PMID: 29795701] Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase., [UniProtKB, PubMed, PubMed]; SSTR3 was significantly up-regulated after intracerebral hemorrhage, along with neuronal apoptosis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 1, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004994 somatostatin receptor activity;GO:0004930 G protein-coupled receptor activity;GO:0005102 signaling receptor binding;GO:0042923 neuropeptide binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005929 cilium;GO:0043005 neuron projection;GO:0097730 non-motile cilium;GO:0060170 ciliary membrane", "go_biological_process": "GO:0060125 negative regulation of growth hormone secretion;GO:0007218 neuropeptide signaling pathway;GO:0007283 spermatogenesis;GO:0030900 forebrain development;GO:0042594 response to starvation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P30936-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.1000100010001.111.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P60192-1", "uniprot_id": [ { "id": "SNAPN_RAT", "url": "https://www.uniprot.org/uniprot/P60192", "type": "external" } ], "mass": 14904.0, "length": 136, "protein_name": "SNARE-associated protein Snapin", "gene_name": "Snapin", "organism": "Rat", "refseq_name": "SNARE-associated protein Snapin isoform 1", "refseq_ac": [ { "id": "NP_001164047", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164047", "type": "external" } ], "gene_names_uniprotkb": "Snapin; Bloc1s7; Snap25bp; Snapap", "gene_names_refseq": "Snapap; Snapin", "protein_names_uniprotkb": "SNARE-associated protein Snapin; BLOC-1 subunit 7; Biogenesis of lysosome-related organelles complex 1 subunit 7; SNAP-associated protein; Synaptosomal-associated protein 25-binding protein", "protein_names_refseq": "BLOC-1 subunit 7; SNARE associated protein snapin; SNARE-associated protein Snapin isoform 1; biogenesis of lysosome-related organelles complex 1 subunit 7; synaptosomal-associated protein 25-binding protein", "tax_id": 10116, "disease": "Hermansky-Pudlak syndrome (Disease Ontology:DOID:3753)", "pathway": " (rno:295217); (R-RNO-432722)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10195194;11283605;12877659;15084593;16760431;18167355;23949442;26946359", "class_list": "", "function": "Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells (PubMed:10195194, PubMed:11283605). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; In pancreatic beta-cells the SNAP-25 accessory protein, snapin, C-terminal H2 domain binds SNAP-25 through its N-terminal Sn-1 domain., [RefSeq, PubMed]; Snapin may not have a role as a SNARE regulator in neurotransmitter release, as had been previously thought [SNAPIN], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0000149 SNARE binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0030141 secretory granule;GO:0045202 synapse", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0072553 terminal button organization;GO:0008090 retrograde axonal transport;GO:0006886 intracellular protein transport;GO:0031175 neuron projection development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P60192-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3KRE8-1", "uniprot_id": [ { "id": "TBB2B_RAT", "url": "https://www.uniprot.org/uniprot/Q3KRE8", "type": "external" } ], "mass": 49953.0, "length": 445, "protein_name": "Tubulin beta-2B chain", "gene_name": "Tubb2b", "organism": "Rat", "refseq_name": "tubulin beta-2B chain", "refseq_ac": [ { "id": "NP_001013908", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013908", "type": "external" } ], "gene_names_uniprotkb": "Tubb2b; Tubb2a", "gene_names_refseq": "RGD1309427; Tubb2b; Tubb2", "protein_names_uniprotkb": "Tubulin beta-2B chain; T beta-15", "protein_names_refseq": "beta-tubulin T beta15 (aa 1-445); t beta-15; tubulin beta-2B chain; tubulin, beta 2", "tax_id": 10116, "disease": "", "pathway": " (rno:291081); (R-RNO-190840); (R-RNO-2132295); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-3371497); (R-RNO-380320); (R-RNO-437239); (R-RNO-5610787); (R-RNO-5620920); (R-RNO-5620924); (R-RNO-5626467); (R-RNO-5663220); (R-RNO-6807878); (R-RNO-6811434); (R-RNO-6811436); (R-RNO-68877); (R-RNO-8852276); (R-RNO-8955332); (R-RNO-9646399); (R-RNO-9648025); (R-RNO-9668328); (R-RNO-983189); (R-RNO-9833482)", "pathway_count": 24, "publication_count": 7, "publication_id_list": "12112145;18683930;19465910;22673903;26306046;2868892;38843836", "class_list": "", "function": "Distribution in developmental and adult rat tissues, [RefSeq, PubMed]; Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:19465910). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts. Implicated in neuronal migration (By similarity)., [UniProtKB, PubMed, UniProtKB]; Tubulin tail sequences and post-translational modifications regulate closure of mitochondrial voltage-dependent anion channel, VDAC., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A3KMR7;P04691", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0015630 microtubule cytoskeleton;GO:0098685 Schaffer collateral - CA1 synapse", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0001764 neuron migration;GO:0021987 cerebral cortex development;GO:0050804 modulation of chemical synaptic transmission;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q3KRE8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5EB62-1", "uniprot_id": [ { "id": "S2546_RAT", "url": "https://www.uniprot.org/uniprot/Q5EB62", "type": "external" } ], "mass": 46210.0, "length": 418, "protein_name": "Mitochondrial outer membrane protein SLC25A46", "gene_name": "Slc25a46", "organism": "Rat", "refseq_name": "mitochondrial outer membrane protein SLC25A46", "refseq_ac": [ { "id": "NP_001093985", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093985", "type": "external" } ], "gene_names_uniprotkb": "Slc25a46", "gene_names_refseq": "RGD1305072; Slc25a46", "protein_names_uniprotkb": "Mitochondrial outer membrane protein SLC25A46; Solute carrier family 25 member 46", "protein_names_refseq": "mitochondrial outer membrane protein SLC25A46", "tax_id": 10116, "disease": "Charcot-Marie-Tooth disease type 6 (Disease Ontology:DOID:0080068); pontocerebellar hypoplasia type 1E (Disease Ontology:DOID:0112330); neuropathy (Disease Ontology:DOID:870)", "pathway": " (rno:291709)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16949250;22673903;36942724", "class_list": "", "function": "SLC25A46 promotes mitochondrial fission and mediates resistance to lipotoxic stress in INS-1E insulin-secreting cells., [RefSeq, PubMed]; Transmembrane protein of the mitochondrial outer membrane that controls mitochondrial organization. May regulate the assembly of the MICOS (mitochondrial contact site and cristae organizing system) complex which is essential to the biogenesis and dynamics of mitochondrial cristae, the inwards folds of the inner mitochondrial membrane. Through its interaction with the EMC (endoplasmic reticulum membrane protein complex), could regulate mitochondrial lipid homeostasis and thereby mitochondrial fission., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0090149 mitochondrial membrane fission;GO:0048936 peripheral nervous system neuron axonogenesis;GO:0006839 mitochondrial transport;GO:0016358 dendrite development;GO:0007416 synapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5EB62-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIF6-1", "uniprot_id": [ { "id": "TBA4A_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIF6", "type": "external" } ], "mass": 49924.0, "length": 448, "protein_name": "Tubulin alpha-4A chain", "gene_name": "Tuba4a", "organism": "Rat", "refseq_name": "tubulin alpha-4A chain isoform 1", "refseq_ac": [ { "id": "NP_001007005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007005", "type": "external" } ], "gene_names_uniprotkb": "Tuba4a; Tuba4", "gene_names_refseq": "Tuba4a; Tuba4", "protein_names_uniprotkb": "Tubulin alpha-4A chain; 3.6.5.-; Alpha-tubulin 4; Tubulin alpha-4 chain", "protein_names_refseq": "alpha-tubulin 4; tubulin alpha-4 chain; tubulin alpha-4A chain isoform 1; tubulin alpha-4A chain; tubulin, alpha 4", "tax_id": 10116, "disease": "lissencephaly (Disease Ontology:DOID:0050453); amyotrophic lateral sclerosis type 22 (Disease Ontology:DOID:0060355); polymicrogyria (Disease Ontology:DOID:0080918); lissencephaly 3 (Disease Ontology:DOID:0112232); microlissencephaly (Disease Ontology:DOID:0112234)", "pathway": " (rno:316531); (R-RNO-114608); (R-RNO-190840); (R-RNO-2132295); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-2565942); (R-RNO-3371497); (R-RNO-380259); (R-RNO-380270); (R-RNO-380284); (R-RNO-380320); (R-RNO-437239); (R-RNO-5610787); (R-RNO-5620912); (R-RNO-5620920); (R-RNO-5620924); (R-RNO-5626467); (R-RNO-5663220); (R-RNO-6807878); (R-RNO-6811434); (R-RNO-6811436); (R-RNO-68877); (R-RNO-8852276); (R-RNO-8854518); (R-RNO-8955332); (R-RNO-9646399); (R-RNO-9648025); (R-RNO-9668328); (R-RNO-983189); (R-RNO-9833482)", "pathway_count": 31, "publication_count": 4, "publication_id_list": "18683930;22673903;34502162;38843836", "class_list": "", "function": "Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "5.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.1", "type": "external" }, { "id": "3.4.22.49", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.49", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.3", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.124", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.15.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.15.1.1", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.4.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.41", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "6.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "2.3.1.108", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.108", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" } ], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0016787 hydrolase activity;GO:0019899 enzyme binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005874 microtubule;GO:0005929 cilium;GO:0045121 membrane raft", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0030182 neuron differentiation;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q5XIF6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63327-1", "uniprot_id": [ { "id": "MOBP_RAT", "url": "https://www.uniprot.org/uniprot/Q63327", "type": "external" } ], "mass": 19103.0, "length": 170, "protein_name": "Myelin-associated oligodendrocyte basic protein", "gene_name": "Mobp", "organism": "Rat", "refseq_name": "myelin-associated oligodendrocyte basic protein isoform 1", "refseq_ac": [ { "id": "NP_036852", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036852", "type": "external" } ], "gene_names_uniprotkb": "Mobp", "gene_names_refseq": "Mobp81p; Mobp81; Mobp", "protein_names_uniprotkb": "Myelin-associated oligodendrocyte basic protein", "protein_names_refseq": "Myelin-associated/Oligodendrocytic Basic Protein-81; RNMOBP81P; myelin-associated oligodendrocyte basic protein isoform 1; myelin-associated oligodendrocytic basic protein", "tax_id": 10116, "disease": "hypothyroidism (Disease Ontology:DOID:1459); frontotemporal dementia (Disease Ontology:DOID:9255)", "pathway": " (rno:25037)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10537049;22673903;7989345;8551331", "class_list": "", "function": "May play a role in compacting or stabilizing the myelin sheath, possibly by binding the negatively charged acidic phospholipids of the cytoplasmic membrane., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q63328;Q63343;Q63519;Q64266;Q9QZV5", "ec_number_list": [], "go_molecular_function": "GO:0019911 structural constituent of myelin sheath", "go_cellular_component": "GO:0005739 mitochondrion;GO:0048471 perinuclear region of cytoplasm;GO:0036464 cytoplasmic ribonucleoprotein granule", "go_biological_process": "GO:0032289 central nervous system myelin formation;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q63327-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXY9-1", "uniprot_id": [ { "id": "SPZ1_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXY9", "type": "external" } ], "mass": 45814.0, "length": 400, "protein_name": "Spermatogenic leucine zipper protein 1", "gene_name": "Spz1", "organism": "Rat", "refseq_name": "spermatogenic leucine zipper protein 1", "refseq_ac": [ { "id": "NP_001019468", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019468", "type": "external" } ], "gene_names_uniprotkb": "Spz1", "gene_names_refseq": "Spz1", "protein_names_uniprotkb": "Spermatogenic leucine zipper protein 1", "protein_names_refseq": "spermatogenic Zip 1; spermatogenic leucine zipper protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:499510)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Transcription factor that binds to the DNA sequence 5'-CANNTG-3'(E box) and the G-box motif. May play an important role in the regulation of cell proliferation and differentiation during spermatogenesis (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0070888 E-box binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AXY9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYL6-2", "uniprot_id": [ { "id": "MIEAP_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYL6", "type": "external" } ], "mass": 62633.0, "length": 556, "protein_name": "Mitochondria-eating protein", "gene_name": "Spata18", "organism": "Rat", "refseq_name": "mitochondria-eating protein isoform 1", "refseq_ac": [ { "id": "NP_955406", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955406", "type": "external" } ], "gene_names_uniprotkb": "Spata18; Mieap; Spetex1", "gene_names_refseq": "Spata18; spetex-1", "protein_names_uniprotkb": "Mitochondria-eating protein; Spermatid-expressing gene 1 protein; Spermatogenesis-associated protein 18; Spetex-1", "protein_names_refseq": "mitochondria-eating protein isoform 1; mitochondria-eating protein; spermatid-expressing gene 1 protein; spermatid-expressing gene-1; spermatogenesis-associated protein 18", "tax_id": 10116, "disease": "", "pathway": " (rno:289586)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15236321;20108326;22673903", "class_list": "", "function": "Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Binds cardiolipin. May form molecular condensates (non-membrane-bounded organelles) within mitochondria that compartmentalize and promote cardiolipin metabolism., [UniProtKB, UniProtKB]; Potential role of spetex-1 in spermatogenesis, especially in cell differentiation, [RefSeq, PubMed]; These data suggested that Spetex-1, a new component of satellite fibrils, might be involved in the structural stability of the sperm flagellar middle piece and functions in co-operation with Tektin4., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6JD28;D3ZEU0;Q764P0", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:1901612 cardiolipin binding;GO:0140693 molecular condensate scaffold activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005759 mitochondrial matrix;GO:0005829 cytosol", "go_biological_process": "GO:1900210 positive regulation of cardiolipin metabolic process;GO:0007283 spermatogenesis;GO:0035694 mitochondrial protein catabolic process;GO:0035695 mitophagy by internal vacuole formation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6AYL6-2", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q925F0-1", "uniprot_id": [ { "id": "SMPX_RAT", "url": "https://www.uniprot.org/uniprot/Q925F0", "type": "external" } ], "mass": 9121.0, "length": 85, "protein_name": "Small muscular protein", "gene_name": "Smpx", "organism": "Rat", "refseq_name": "small muscular protein", "refseq_ac": [ { "id": "NP_445847", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445847", "type": "external" } ], "gene_names_uniprotkb": "Smpx; Srmx", "gene_names_refseq": "Smpx", "protein_names_uniprotkb": "Small muscular protein; Stretch-responsive skeletal muscle protein", "protein_names_refseq": "small muscular protein; stretch-responsive skeletal muscle protein", "tax_id": 10116, "disease": "X-linked deafness 4 (Disease Ontology:DOID:0111735)", "pathway": " (rno:84416)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10598820;22673903", "class_list": "", "function": "Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031430 M band;GO:0043034 costamere;GO:0005927 muscle tendon junction", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q925F0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62925-1", "uniprot_id": [ { "id": "M3K1_RAT", "url": "https://www.uniprot.org/uniprot/Q62925", "type": "external" } ], "mass": 161315.0, "length": 1493, "protein_name": "Mitogen-activated protein kinase kinase kinase 1", "gene_name": "Map3k1", "organism": "Rat", "refseq_name": "mitogen-activated protein kinase kinase kinase 1", "refseq_ac": [ { "id": "NP_446339", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446339", "type": "external" } ], "gene_names_uniprotkb": "Map3k1; Mekk1; Mekk", "gene_names_refseq": "Map3k1; Mekk1", "protein_names_uniprotkb": "Mitogen-activated protein kinase kinase kinase 1; 2.7.11.25; MAPK/ERK kinase kinase 1; MEK kinase 1; MEKK 1", "protein_names_refseq": "MAPK/ERK kinase kinase 1; MEK kinase 1; MEKK 1; mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase; mitogen-activated protein kinase kinase kinase 1", "tax_id": 10116, "disease": "diffuse gastric cancer (Disease Ontology:DOID:0080763); 46,XY sex reversal 6 (Disease Ontology:DOID:0111769); stomach cancer (Disease Ontology:DOID:10534); breast cancer (Disease Ontology:DOID:1612); rectum cancer (Disease Ontology:DOID:1993); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:116667); (R-RNO-166058); (R-RNO-2871796); (R-RNO-975138); (R-RNO-975871)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "11784851;17761173;22673903;27662850;8643568", "class_list": "", "function": "Component of a protein kinase signal transduction cascade (PubMed:11784851). Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:11784851). May phosphorylate the MAPK8/JNK1 kinase (By similarity). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway (PubMed:11784851)., [UniProtKB, UniProtKB, PubMed]; Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. May phosphorylate the MAPK8/JNK1 kinase. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; MEKK1 may play a role in promoting the brain damage following intracerebral hemorrhage, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane;GO:0031941 filamentous actin;GO:0070160 tight junction", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0043065 positive regulation of apoptotic process;GO:0043410 positive regulation of MAPK cascade;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0046330 positive regulation of JNK cascade", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q62925-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08460-1", "uniprot_id": [ { "id": "NID1_RAT", "url": "https://www.uniprot.org/uniprot/P08460", "type": "external" } ], "mass": 35661.0, "length": 324, "protein_name": "Nidogen-1", "gene_name": "Nid1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Nid1; Nid", "gene_names_refseq": "", "protein_names_uniprotkb": "Nidogen-1; Entactin; NID-1", "protein_names_refseq": "", "tax_id": 10116, "disease": "Waardenburg syndrome type 4B (Disease Ontology:DOID:0110954); Hirschsprung's disease (Disease Ontology:DOID:10487); Waardenburg syndrome (Disease Ontology:DOID:9258)", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "10727019;3264556;3470744", "class_list": "", "function": "Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q712L9", "ec_number_list": [], "go_molecular_function": "GO:0005518 collagen binding;GO:0043236 laminin binding;GO:0050840 extracellular matrix binding;GO:0043394 proteoglycan binding;GO:0043237 laminin-1 binding", "go_cellular_component": "GO:0031012 extracellular matrix;GO:0071944 cell periphery;GO:0005604 basement membrane", "go_biological_process": "GO:0030198 extracellular matrix organization;GO:0007160 cell-matrix adhesion;GO:0010811 positive regulation of cell-substrate adhesion;GO:0032836 glomerular basement membrane development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P08460-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VHK7-1", "uniprot_id": [ { "id": "HDGF_RAT", "url": "https://www.uniprot.org/uniprot/Q8VHK7", "type": "external" } ], "mass": 26488.0, "length": 237, "protein_name": "Hepatoma-derived growth factor", "gene_name": "Hdgf", "organism": "Rat", "refseq_name": "hepatoma-derived growth factor", "refseq_ac": [ { "id": "NP_446159", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446159", "type": "external" } ], "gene_names_uniprotkb": "Hdgf", "gene_names_refseq": "Hdgf", "protein_names_uniprotkb": "Hepatoma-derived growth factor; HDGF", "protein_names_refseq": "hepatoma-derived growth factor", "tax_id": 10116, "disease": "", "pathway": " (rno:114499)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11481329;16384999;16396499;16641100;22673903;34273665", "class_list": "", "function": "Acts as a transcriptional repressor (By similarity). Has mitogenic activity for fibroblasts (By similarity). Heparin-binding protein (By similarity)., [UniProtKB, UniProtKB]; HDGF contains a true bipartite nuclear localization sequence with all three lysines necessary for nuclear targeting. Nuclear targeting of HDGF is required for HDGF stimulation of DNA replication in VSM., [RefSeq, PubMed]; Oxidized low-density lipoprotein induced hepatoma-derived growth factor upregulation mediates foam cell formation of cultured rat aortic vascular smooth muscle cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q923W3", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0008201 heparin binding;GO:0000166 nucleotide binding;GO:0003714 transcription corepressor activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0017053 transcription repressor complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0043524 negative regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8VHK7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P39052-1", "uniprot_id": [ { "id": "DYN2_RAT", "url": "https://www.uniprot.org/uniprot/P39052", "type": "external" } ], "mass": 98230.0, "length": 870, "protein_name": "Dynamin-2", "gene_name": "Dnm2", "organism": "Rat", "refseq_name": "dynamin-2", "refseq_ac": [ { "id": "NP_037331", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037331", "type": "external" } ], "gene_names_uniprotkb": "Dnm2; Dyn2", "gene_names_refseq": "DYIIAAB; Dnm2", "protein_names_uniprotkb": "Dynamin-2; 3.6.5.5", "protein_names_refseq": "dynamin-2", "tax_id": 10116, "disease": "lethal congenital contracture syndrome (Disease Ontology:DOID:0060558); Charcot-Marie-Tooth disease dominant intermediate B (Disease Ontology:DOID:0110197); centronuclear myopathy 1 (Disease Ontology:DOID:0111223); microcytic anemia (Disease Ontology:DOID:11252); centronuclear myopathy (Disease Ontology:DOID:14717); cystic kidney disease (Disease Ontology:DOID:2975); myopathy (Disease Ontology:DOID:423); collagen disease (Disease Ontology:DOID:854)", "pathway": " (rno:25751); (R-RNO-166016); (R-RNO-190873); (R-RNO-196025); (R-RNO-203641); (R-RNO-2132295); (R-RNO-432720); (R-RNO-432722); (R-RNO-437239); (R-RNO-8856828); (R-RNO-9766229)", "pathway_count": 11, "publication_count": 16, "publication_id_list": "11583995;15048127;16234328;16325581;17257598;19605363;19995918;21195118;21210813;34107845;35620056;36102975;8290576;8308025;9438853;9725914", "class_list": "", "function": "Asymmetric distribution of dynamin-2 and beta-catenin relative to tight junction spikes in alveolar epithelial cells., [RefSeq, PubMed]; Catalyzes the hydrolysis of GTP and utilizes this energy to mediate vesicle scission at plasma membrane during endocytosis and filament remodeling at many actin structures during organization of the actin cytoskeleton (PubMed:19605363, PubMed:19995918, PubMed:35620056). Plays an important role in vesicular trafficking processes, namely clathrin-mediated endocytosis (CME), exocytic and clathrin-coated vesicle from the trans-Golgi network, and PDGF stimulated macropinocytosis (PubMed:19995918, PubMed:21195118, PubMed:9438853). During vesicular trafficking process, associates to the membrane, through lipid binding, and self-assembles into ring-like structure through oligomerization to form a helical polymer around the vesicle membrane and leading to vesicle scission (PubMed:35620056). Plays a role in organization of the actin cytoskeleton by mediating arrangement of stress fibers and actin bundles in podocytes (PubMed:35620056). During organization of the actin cytoskeleton, self-assembles into ring-like structure that directly bundles actin filaments to form typical membrane tubules decorated with dynamin spiral polymers (PubMed:35620056). Self-assembly increases GTPase activity and the GTP hydrolysis causes the rapid depolymerization of dynamin spiral polymers, and results in dispersion of actin bundles (PubMed:35620056). Remodels, through its interaction with CTTN, bundled actin filaments in a GTPase-dependent manner and plays a role in orchestrating the global actomyosin cytoskeleton (PubMed:19605363). The interaction with CTTN stabilizes the interaction of DNM2 and actin filaments and stimulates the intrinsic GTPase activity that results in actin filament-barbed ends and increases the sensitivity of filaments in bundles to the actin depolymerizing factor, CFL1 (PubMed:19605363). Plays a role in the autophagy process, by participating in the formation of ATG9A vesicles destined for the autophagosomes through its interaction with SNX18, by mediating recycling endosome scission leading to autophagosome release through MAP1LC3B interaction and by regulating maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity). Also plays a role in cytokinesis (PubMed:21195118). May participate in centrosome cohesion through its interaction with TUBG1 (PubMed:15048127). Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (PubMed:21210813). Involved in membrane tubulation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Regulation of fenestra formation via actin-dynamin2 interaction in rat pituitary endothelial cells., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.4.17.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.22", "type": "external" }, { "id": "3.1.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.22.1", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0008017 microtubule binding;GO:0017124 SH3 domain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0001891 phagocytic cup;GO:0005737 cytoplasm;GO:0005768 endosome", "go_biological_process": "GO:0097749 membrane tubulation;GO:0061572 actin filament bundle organization;GO:0006897 endocytosis;GO:0007283 spermatogenesis;GO:0031623 receptor internalization", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P39052-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08921-1", "uniprot_id": [ { "id": "CD2_RAT", "url": "https://www.uniprot.org/uniprot/P08921", "type": "external" } ], "mass": 38413.0, "length": 344, "protein_name": "T-cell surface antigen CD2", "gene_name": "Cd2", "organism": "Rat", "refseq_name": "T-cell surface antigen CD2 precursor", "refseq_ac": [ { "id": "NP_036962", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036962", "type": "external" } ], "gene_names_uniprotkb": "Cd2", "gene_names_refseq": "CD2R; Cd2; LFA-2; LFA2; OX-34; OX34", "protein_names_uniprotkb": "T-cell surface antigen CD2; LFA-2; LFA-3 receptor; OX-34 antigen; T-cell surface antigen T11/Leu-5", "protein_names_refseq": "CD2 antigen; LFA-3 receptor; OX-34 antigen; OX-45 surface antigen homolog to human T lymphocyte CD2 antigen; T-cell surface antigen CD2 precursor; T-cell surface antigen CD2; T-cell surface antigen T11/Leu-5", "tax_id": 10116, "disease": "", "pathway": " (rno:497761)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "1279440;16803907;1682812;19811406;2901293;3102667;32213736;7638192;9731771", "class_list": "", "function": "CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function., [UniProtKB, PubMed, UniProtKB, UniProtKB]; CD2 is a surface marker for mouse and rat spermatogonial stem cells., [RefSeq, PubMed]; CD2/CD28 costimulation is the strongest T cell stimulus in vivo in rat lamina propria., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "F1M9W7;Q5I0M6", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0030971 receptor tyrosine kinase binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0009986 cell surface;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006955 immune response;GO:0098609 cell-cell adhesion;GO:0032760 positive regulation of tumor necrosis factor production;GO:0032729 positive regulation of type II interferon production;GO:0032757 positive regulation of interleukin-8 production", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P08921-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000001000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99P82-1", "uniprot_id": [ { "id": "CLD11_RAT", "url": "https://www.uniprot.org/uniprot/Q99P82", "type": "external" } ], "mass": 22046.0, "length": 207, "protein_name": "Claudin-11", "gene_name": "Cldn11", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cldn11", "gene_names_refseq": "", "protein_names_uniprotkb": "Claudin-11", "protein_names_refseq": "", "tax_id": 10116, "disease": "hypomyelinating leukodystrophy 22 (Disease Ontology:DOID:0070402)", "pathway": " (rno:84588)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11316752;22673903", "class_list": "", "function": "Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia., [UniProtKB, UniProtKB]; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0030054 cell junction;GO:0030424 axon;GO:0045178 basal part of cell", "go_biological_process": "GO:0120192 tight junction assembly;GO:0007155 cell adhesion;GO:0007283 spermatogenesis;GO:0008366 axon ensheathment;GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q99P82-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R491-1", "uniprot_id": [ { "id": "EHD3_RAT", "url": "https://www.uniprot.org/uniprot/Q8R491", "type": "external" } ], "mass": 60791.0, "length": 535, "protein_name": "EH domain-containing protein 3", "gene_name": "Ehd3", "organism": "Rat", "refseq_name": "EH domain-containing protein 3", "refseq_ac": [ { "id": "NP_620245", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620245", "type": "external" } ], "gene_names_uniprotkb": "Ehd3; Ehd2", "gene_names_refseq": "Ehd2; Ehd3", "protein_names_uniprotkb": "EH domain-containing protein 3", "protein_names_refseq": "EH domain-containing protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:192249); (R-RNO-983231)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "15182197;15930129;22673903", "class_list": "", "function": "ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes tubulation of endocytic membranes. Binding to phosphatidic acid induces its membrane tubulation activity. Plays a role in endocytic transport. Involved in early endosome to recycling endosome compartment (ERC), retrograde early endosome to Golgi, and endosome to plasma membrane (rapid recycling) protein transport. Involved in the regulation of Golgi maintenance and morphology. Involved in the recycling of internalized D1 dopamine receptor (By similarity). Plays a role in cardiac protein trafficking probably implicating ANK2. Involved in the ventricular membrane targeting of SLC8A1 and CACNA1C and probably the atrial membrane localization of CACNA1GG and CACNA1H implicated in the regulation of atrial myocyte excitability and cardiac conduction. In conjunction with EHD4 may be involved in endocytic trafficking of KDR/VEGFR2 implicated in control of glomerular function. Involved in the rapid recycling of integrin beta-3 implicated in cell adhesion maintenance. Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing. Plays a role in the formation of the ciliary vesicle, an early step in cilium biogenesis; possibly sharing redundant functions with Ehd1., [UniProtKB, UniProtKB, UniProtKB]; EHD2 also interacted with the clathrin adaptor middle chain subunit micro(1), micro(2), [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0030674 protein-macromolecule adaptor activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005929 cilium", "go_biological_process": "GO:0006897 endocytosis;GO:0015031 protein transport;GO:0051260 protein homooligomerization;GO:0072659 protein localization to plasma membrane;GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8R491-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WUJ3-1", "uniprot_id": [ { "id": "MYOME_RAT", "url": "https://www.uniprot.org/uniprot/Q9WUJ3", "type": "external" } ], "mass": 262042.0, "length": 2324, "protein_name": "Myomegalin", "gene_name": "Pde4dip", "organism": "Rat", "refseq_name": "myomegalin isoform 1", "refseq_ac": [ { "id": "NP_071777", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071777", "type": "external" } ], "gene_names_uniprotkb": "Pde4dip; Pbp46", "gene_names_refseq": "Pde4dip", "protein_names_uniprotkb": "Myomegalin; Phosphodiesterase 4D-interacting protein; Phosphodiesterase-binding protein clone 46", "protein_names_refseq": "myomegalin isoform 1; myomegalin; phosphodiesterase-binding protein clone 46", "tax_id": 10116, "disease": "", "pathway": " (rno:64183)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11134006;21569246", "class_list": "", "function": "Functions as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes (PubMed:11134006). May participate in microtubule dynamics, promoting microtubule assembly, in an isoform-specific manner. Depending upon the cell context, may act at the level of the Golgi apparatus or that of the centrosome. In complex with AKAP9, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. In complex with AKAP9, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension from the centrosome to the cell periphery, a crucial process for directed cell migration, mitotic spindle orientation and cell-cycle progression (By similarity)., [UniProtKB, PubMed, UniProtKB]; MMGL isoform 4 is involved in the phosphorylation of Cardiac Myosin Binding Protein-C as well as cardiac troponin I. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019899 enzyme binding", "go_cellular_component": "GO:1903754 cortical microtubule plus-end;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005813 centrosome", "go_biological_process": "GO:0007098 centrosome cycle;GO:0090063 positive regulation of microtubule nucleation;GO:0030953 astral microtubule organization;GO:0065003 protein-containing complex assembly;GO:1903358 regulation of Golgi organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9WUJ3-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97526-1", "uniprot_id": [ { "id": "NF1_RAT", "url": "https://www.uniprot.org/uniprot/P97526", "type": "external" } ], "mass": 317083.0, "length": 2820, "protein_name": "Neurofibromin", "gene_name": "Nf1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Nf1", "gene_names_refseq": "", "protein_names_uniprotkb": "Neurofibromin; Neurofibromatosis-related protein NF-1", "protein_names_refseq": "", "tax_id": 10116, "disease": "juvenile myelomonocytic leukemia (Disease Ontology:DOID:0050458); spinal neurofibromatosis (Disease Ontology:DOID:0070482); Watson syndrome (Disease Ontology:DOID:0070483); colorectal carcinoma (Disease Ontology:DOID:0080199); neurofibromatosis 1 (Disease Ontology:DOID:0111253); neurofibromatosis-Noonan syndrome (Disease Ontology:DOID:0111683); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); sciatic neuropathy (Disease Ontology:DOID:11446); autistic disorder (Disease Ontology:DOID:12849); colon cancer (Disease Ontology:DOID:219); transient cerebral ischemia (Disease Ontology:DOID:224); malignant astrocytoma (Disease Ontology:DOID:3069); high grade glioma (Disease Ontology:DOID:3070); lung non-small cell carcinoma (Disease Ontology:DOID:3908); optic nerve glioma (Disease Ontology:DOID:4992); plexiform neurofibroma (Disease Ontology:DOID:5151); sleep disorder (Disease Ontology:DOID:535); neurofibromatosis (Disease Ontology:DOID:8712); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (rno:24592); (R-RNO-5658442)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22673903;8982875", "class_list": "", "function": "Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008017 microtubule binding;GO:0008429 phosphatidylethanolamine binding;GO:0031210 phosphatidylcholine binding;GO:0045545 syndecan binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0045124 regulation of bone resorption;GO:0046580 negative regulation of Ras protein signal transduction;GO:0048820 hair follicle maturation;GO:0001889 liver development;GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P97526-1", "record_type": "protein", "filter_code": "0000000.0000111.001000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62655-1", "uniprot_id": [ { "id": "ITF2_RAT", "url": "https://www.uniprot.org/uniprot/Q62655", "type": "external" } ], "mass": 63053.0, "length": 589, "protein_name": "Transcription factor 4", "gene_name": "Tcf4", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Tcf4; Itf2; Sef2", "gene_names_refseq": "", "protein_names_uniprotkb": "Transcription factor 4; ITF-2; Immunoglobulin transcription factor 2; R8f DNA-binding protein; RITF-2; SEF-2; SL3-3 enhancer factor 2; TCF-4", "protein_names_refseq": "", "tax_id": 10116, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); Pitt-Hopkins syndrome (Disease Ontology:DOID:0060488); Fuchs' endothelial dystrophy (Disease Ontology:DOID:11555); Lynch syndrome (Disease Ontology:DOID:3883); schizophrenia (Disease Ontology:DOID:5419); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:84382); (R-RNO-525793)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22673903;7913462", "class_list": "", "function": "Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Interacts with the CCAAT displacement protein (CDP2) to bind the tyrosine hydroxylase enhancer., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99N33", "ec_number_list": [], "go_molecular_function": "GO:0001093 TFIIB-class transcription factor binding;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0000785 chromatin;GO:1990907 beta-catenin-TCF complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010629 negative regulation of gene expression;GO:0045666 positive regulation of neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q62655-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IMY8-1", "uniprot_id": [ { "id": "HNRPU_RAT", "url": "https://www.uniprot.org/uniprot/Q6IMY8", "type": "external" } ], "mass": 87732.0, "length": 798, "protein_name": "Heterogeneous nuclear ribonucleoprotein U", "gene_name": "Hnrnpu", "organism": "Rat", "refseq_name": "heterogeneous nuclear ribonucleoprotein U", "refseq_ac": [ { "id": "NP_476480", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476480", "type": "external" } ], "gene_names_uniprotkb": "Hnrnpu; Hnrpu; rCG_20317", "gene_names_refseq": "Hnrnpu; Hnrpu; SAF-A; SN1; SP120; hnRNP U", "protein_names_uniprotkb": "Heterogeneous nuclear ribonucleoprotein U; SAF-A; SP120; Scaffold-attachment factor A; hnRNP U", "protein_names_refseq": "heterogeneous nuclear ribonucleoprotein U; scaffold-attachment factor A; system N1 Na+ and H+-coupled glutamine transporter; transporter protein", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 54 (Disease Ontology:DOID:0080418); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:117280); (R-RNO-72163); (R-RNO-72203); (R-RNO-9770562)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "20554522;22673903;34502162;34585626;37540655;38843836;39216234;8509422", "class_list": "", "function": "DNA- and RNA-binding protein involved in several cellular processes such as nuclear chromatin organization, telomere-length regulation, transcription, mRNA alternative splicing and stability, Xist-mediated transcriptional silencing and mitotic cell progression. Plays a role in the regulation of interphase large-scale gene-rich chromatin organization through chromatin-associated RNAs (caRNAs) in a transcription-dependent manner, and thereby maintains genomic stability. Required for the localization of the long non-coding Xist RNA on the inactive chromosome X (Xi) and the subsequent initiation and maintenance of X-linked transcriptional gene silencing during X-inactivation (By similarity). Required for the topoisomerase TOP2A protein stability and activity in a RNA-dependent manner (PubMed:20554522). Plays a role as a RNA polymerase II (Pol II) holoenzyme transcription regulator. Promotes transcription initiation by direct association with the core-TFIIH basal transcription factor complex for the assembly of a functional pre-initiation complex with Pol II in a actin-dependent manner. Blocks Pol II transcription elongation activity by inhibiting the C-terminal domain (CTD) phosphorylation of Pol II and dissociates from Pol II pre-initiation complex prior to productive transcription elongation. Positively regulates CBX5-induced transcriptional gene silencing and retention of CBX5 in the nucleus. Negatively regulates glucocorticoid-mediated transcriptional activation. Key regulator of transcription initiation and elongation in embryonic stem cells upon leukemia inhibitory factor (LIF) signaling. Involved in the long non-coding RNA H19-mediated Pol II transcriptional repression. Participates in the circadian regulation of the core clock component BMAL1 transcription. Plays a role in the regulation of telomere length. Plays a role as a global pre-mRNA alternative splicing modulator by regulating U2 small nuclear ribonucleoprotein (snRNP) biogenesis. Plays a role in mRNA stability. Component of the CRD-mediated complex that promotes MYC mRNA stabilization. Enhances the expression of specific genes, such as tumor necrosis factor TNFA, by regulating mRNA stability, possibly through binding to the 3'-untranslated region (UTR). Plays a role in mitotic cell cycle regulation. Involved in the formation of stable mitotic spindle microtubules (MTs) attachment to kinetochore, spindle organization and chromosome congression. Phosphorylation at Ser-58 by PLK1 is required for chromosome alignement and segregation and progression through mitosis. Also contributes to the targeting of AURKA to mitotic spindle MTs (By similarity). Binds to double- and single-stranded DNA and RNA, poly(A), poly(C) and poly(G) oligoribonucleotides (PubMed:20554522). Binds to chromatin-associated RNAs (caRNAs) (By similarity). Associates with chromatin to scaffold/matrix attachment region (S/MAR) elements in DNA (PubMed:8509422). Associates with chromatin in a chromatin-associated RNAs (caRNAs)-dependent manner. Binds to the Xist RNA. Binds the long non-coding H19 RNA. Binds to SMN1/2 pre-mRNAs at G/U-rich regions. Binds to small nuclear RNAs (snRNAs). Binds to the 3'-UTR of TNFA mRNA. Binds (via RNA-binding RGG-box region) to the long non-coding Xist RNA; this binding is direct and bridges the Xist RNA and the inactive chromosome X (Xi). Also negatively regulates embryonic stem cell differentiation upon LIF signaling. Required for embryonic development (By similarity). Binds to brown fat long non-coding RNA 1 (Blnc1); facilitates the recruitment of Blnc1 by ZBTB7B required to drive brown and beige fat development and thermogenesis (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]; Deacetylation of HnRNP U mediated by sirtuin1 ameliorates aged rat with liver fibrosis via inhibiting p53-related senescence and NLRP3-related inflammation., [RefSeq, PubMed]; MicroRNA-132-3p alleviates neuron apoptosis and impairments of learning and memory abilities in Alzheimer's disease by downregulation of HNRNPU stabilized BACE1., [RefSeq, PubMed]; Selective DNA-binding of SP120 (rat ortholog of human hnRNP U) is mediated by arginine-glycine rich domain and modulated by RNA. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0036002 pre-mRNA binding;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0003779 actin binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0016071 mRNA metabolic process;GO:0070934 CRD-mediated mRNA stabilization;GO:2000373 positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity;GO:2000648 positive regulation of stem cell proliferation;GO:2000767 positive regulation of cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q6IMY8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKA7-1", "uniprot_id": [ { "id": "HCN4_RAT", "url": "https://www.uniprot.org/uniprot/Q9JKA7", "type": "external" } ], "mass": 128761.0, "length": 1198, "protein_name": "Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4", "gene_name": "Hcn4", "organism": "Rat", "refseq_name": "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4", "refseq_ac": [ { "id": "NP_067690", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067690", "type": "external" } ], "gene_names_uniprotkb": "Hcn4", "gene_names_refseq": "Hcn4", "protein_names_uniprotkb": "Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4", "protein_names_refseq": "hyperpolarization-activated, cyclic nucleotide-gated K+ 4; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4", "tax_id": 10116, "disease": "Brugada syndrome 8 (Disease Ontology:DOID:0110225); Gilles de la Tourette syndrome (Disease Ontology:DOID:11119); sick sinus syndrome (Disease Ontology:DOID:13884); generalized epilepsy (Disease Ontology:DOID:1827)", "pathway": " (rno:59266); (R-RNO-1296061)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10400919;11000485;11675786;22673903;27569278;31409881;36214984;36574099;37643180;38843836", "class_list": "", "function": "DNA methylation cooperates with H3K9me2 at HCN4 promoter to regulate the differentiation of bone marrow mesenchymal stem cells into pacemaker-like cells. Publication Status: Online-Only, [RefSeq, PubMed]; Depressed HCN4 function in the type 2 diabetic sinoatrial node., [RefSeq, PubMed]; Glucocorticoid Receptor/HCN4 Channels Interaction in Spinal Dorsal Horn Participates in the Regulation of Neuropathic Pain after Peripheral Nerve Injury in Rats., [RefSeq, PubMed]; Hyperpolarization-activated ion channel that are permeable to Na(+) and K(+) ions with very slow activation and inactivation. Exhibits higher selectivity for K(+) over Na(+) ions. Contributes to the native pacemaker currents in heart (If) that regulate the rhythm of heart beat. Contributes to the native pacemaker currents in neurons (Ih) (By similarity). May mediate responses to sour stimuli (PubMed:11675786)., [UniProtKB, PubMed, UniProtKB]; Sinus node-like pacemaker mechanisms regulate ectopic pacemaker activity in the adult rat atrioventricular ring. Publication Status: Online-Only, [RefSeq, PubMed]; The expression and relative abundances of HCN channels in cerebellum and primary cultures of cerebellar granule neurons, is described., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 1, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9QZW4", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005267 potassium channel activity;GO:0005248 voltage-gated sodium channel activity;GO:0005222 intracellularly cAMP-activated cation channel activity;GO:0005249 voltage-gated potassium channel activity;GO:0030552 cAMP binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0042391 regulation of membrane potential;GO:0071320 cellular response to cAMP;GO:0086091 regulation of heart rate by cardiac conduction;GO:0008016 regulation of heart contraction", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9JKA7-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6JE36-1", "uniprot_id": [ { "id": "NDRG1_RAT", "url": "https://www.uniprot.org/uniprot/Q6JE36", "type": "external" } ], "mass": 42955.0, "length": 394, "protein_name": "Protein NDRG1", "gene_name": "Ndrg1", "organism": "Rat", "refseq_name": "protein NDRG1", "refseq_ac": [ { "id": "NP_001011991", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011991", "type": "external" } ], "gene_names_uniprotkb": "Ndrg1; Ndr1", "gene_names_refseq": "Ndr1; Ndrg1", "protein_names_uniprotkb": "Protein NDRG1; N-myc downstream-regulated gene 1 protein; Protein Ndr1", "protein_names_refseq": "N-myc downstream regulated gene 1; N-myc downstream-regulated gene 1 protein; protein NDRG1; protein Ndr1", "tax_id": 10116, "disease": "Charcot-Marie-Tooth disease type 4D (Disease Ontology:DOID:0110186)", "pathway": " (rno:299923)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;37356737", "class_list": "", "function": "Role of KLF4/NDRG1/DRP1 axis in hypoxia-induced pulmonary hypertension., [RefSeq, PubMed]; Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking notably of the Schwann cell and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0045296 cadherin binding;GO:0031267 small GTPase binding;GO:0016151 nickel cation binding;GO:0043015 gamma-tubulin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005874 microtubule", "go_biological_process": "GO:0007165 signal transduction;GO:0008285 negative regulation of cell population proliferation;GO:0071456 cellular response to hypoxia;GO:0032287 peripheral nervous system myelin maintenance;GO:0030330 DNA damage response, signal transduction by p53 class mediator", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6JE36-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZE55-1", "uniprot_id": [ { "id": "PCDH8_RAT", "url": "https://www.uniprot.org/uniprot/D3ZE55", "type": "external" } ], "mass": 113191.0, "length": 1069, "protein_name": "Protocadherin-8", "gene_name": "Pcdh8", "organism": "Rat", "refseq_name": "protocadherin-8 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001398904", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001398904", "type": "external" } ], "gene_names_uniprotkb": "Pcdh8", "gene_names_refseq": "Arcadlin; Pcdh8", "protein_names_uniprotkb": "Protocadherin-8; Activity-regulated cadherin-like protein; Arcadlin", "protein_names_refseq": "activity-regulated cadherin-like protein; protocadherin-8 isoform 1 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:64865)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10383464;17988630;22673903;24090084;31981722", "class_list": "", "function": "Arcadlin knockout increases the number of dendritic spines, and the phenotype is rescued by siRNA knockdown of N-cadherin. T, [RefSeq, PubMed]; Calcium-dependent cell-adhesion protein. May play a role in activity-induced synaptic reorganization underlying long term memory. Could be involved in CDH2 internalization through TAOK2/p38 MAPK pathway. In hippocampal neurons, may play a role in the down-regulation of dendritic spines, maybe through its action on CDH2 endocytosis., [UniProtKB, PubMed, PubMed]; Serotonin induces Arcadlin in hippocampal neurons., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A1A5N4;Q9WVR2", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0045202 synapse;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0007268 chemical synaptic transmission;GO:0098609 cell-cell adhesion;GO:0016331 morphogenesis of embryonic epithelium;GO:0001756 somitogenesis;GO:0050804 modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "D3ZE55-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.1000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63159-1", "uniprot_id": [ { "id": "HMGB1_RAT", "url": "https://www.uniprot.org/uniprot/P63159", "type": "external" } ], "mass": 24894.0, "length": 215, "protein_name": "High mobility group protein B1", "gene_name": "Hmgb1l2; Hmgb1; LOC134483981", "organism": "Rat", "refseq_name": "high mobility group protein B1", "refseq_ac": [ { "id": "NP_037095", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037095", "type": "external" } ], "gene_names_uniprotkb": "Hmgb1l2; Hmgb1; LOC134483981; AABR07035218.1; Hmg-1; Hmg1; Hmgb1l2; LOC108349189; LOC134483981; LOC134485624", "gene_names_refseq": "Ac2-008; Hmg1; Hmgb1", "protein_names_uniprotkb": "High mobility group protein B1; Amphoterin; HMG-1; Heparin-binding protein p30; High mobility group protein 1", "protein_names_refseq": "Ac2-008-like; HMG-1; amphoterin; heparin-binding protein p30; high mobility group 1; high mobility group protein 1; high mobility group protein B1", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); hydrocephalus (Disease Ontology:DOID:10908); sciatic neuropathy (Disease Ontology:DOID:11446); Kawasaki disease (Disease Ontology:DOID:13378); obstructive jaundice (Disease Ontology:DOID:13603); alcohol use disorder (Disease Ontology:DOID:1574); atherosclerosis (Disease Ontology:DOID:1936); colon adenocarcinoma (Disease Ontology:DOID:234); high grade glioma (Disease Ontology:DOID:3070); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); brain infarction (Disease Ontology:DOID:3454); middle cerebral artery infarction (Disease Ontology:DOID:3525); cerebral infarction (Disease Ontology:DOID:3526); systemic scleroderma (Disease Ontology:DOID:418); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); periodontitis (Disease Ontology:DOID:824)", "pathway": " (rno:108349189); (rno:134483981); (rno:25459); (R-RNO-140342); (R-RNO-3000471); (R-RNO-445989); (R-RNO-5620971); (R-RNO-5686938); (R-RNO-6798695); (R-RNO-879415); (R-RNO-933542)", "pathway_count": 11, "publication_count": 37, "publication_id_list": "10830965;10866811;10952726;11154118;11513603;12110890;12183440;12486007;14532127;15379539;15808513;16962095;17269659;18277947;1885601;20547845;20819940;22105604;22869893;23446148;23508573;23519706;23994764;24551219;2461949;25048472;2922595;33380312;3684582;38279466;38466011;38688613;39129231;7592757;8467791;8527432;9507007", "class_list": "", "function": "Box A of HMGB1 Maintains the DNA Gap and Prevents DDR-induced Kidney Injury in D-galactose Induction Rats., [RefSeq, PubMed]; In the cytoplasm proposed to dissociate the BECN1:BCL2 complex via competitive interaction with BECN1 leading to autophagy activation (By similarity). Can protect BECN1 and ATG5 from calpain-mediated cleavage and thus proposed to control their proautophagic and proapoptotic functions and to regulate the extent and severity of inflammation-associated cellular injury (By similarity). In myeloid cells has a protective role against endotoxemia and bacterial infection by promoting autophagy (By similarity). Involved in endosomal translocation and activation of TLR9 in response to CpG-DNA in macrophages (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; In the extracellular compartment (following either active secretion or passive release) involved in regulation of the inflammatory response. Fully reduced HGMB1 (which subsequently gets oxidized after release) in association with CXCL12 mediates the recruitment of inflammatory cells during the initial phase of tissue injury; the CXCL12:HMGB1 complex triggers CXCR4 homodimerization (PubMed:22869893). Induces the migration of monocyte-derived immature dendritic cells and seems to regulate adhesive and migratory functions of neutrophils implicating AGER/RAGE and ITGAM (By similarity). Can bind to various types of DNA and RNA including microbial unmethylated CpG-DNA to enhance the innate immune response to nucleic acids. Proposed to act in promiscuous DNA/RNA sensing which cooperates with subsequent discriminative sensing by specific pattern recognition receptors. Promotes extracellular DNA-induced AIM2 inflammasome activation implicating AGER/RAGE (By similarity). Disulfide HMGB1 binds to transmembrane receptors, such as AGER/RAGE, TLR2, TLR4 and probably TREM1, thus activating their signal transduction pathways. Mediates the release of cytokines/chemokines such as TNF, IL-1, IL-6, IL-8, CCL2, CCL3, CCL4 and CXCL10 (PubMed:10952726, PubMed:20547845, PubMed:22869893). Promotes secretion of interferon-gamma by macrophage-stimulated natural killer (NK) cells in concert with other cytokines like IL-2 or IL-12. TLR4 is proposed to be the primary receptor promoting macrophage activation and signaling through TLR4 seems to implicate LY96/MD-2 (By similarity). In bacterial LPS- or LTA-mediated inflammatory responses binds to the endotoxins and transfers them to CD14 for signaling to the respective TLR4:LY96 and TLR2 complexes (PubMed:23508573). Contributes to tumor proliferation by association with ACER/RAGE (PubMed:10830965). Can bind to IL1-beta and signals through the IL1R1:IL1RAP receptor complex (By similarity). Binding to class A CpG activates cytokine production in plasmacytoid dendritic cells implicating TLR9, MYD88 and AGER/RAGE and can activate autoreactive B cells (By similarity). Via HMGB1-containing chromatin immune complexes may also promote B cell responses to endogenous TLR9 ligands through a B-cell receptor (BCR)-dependent and ACER/RAGE-independent mechanism (By similarity). Inhibits phagocytosis of apoptotic cells by macrophages; the function is dependent on poly-ADP-ribosylation and involves binding to phosphatidylserine on the cell surface of apoptotic cells (By similarity). In adaptive immunity may be involved in enhancing immunity through activation of effector T-cells and suppression of regulatory T (TReg) cells (By similarity). In contrast, without implicating effector or regulatory T-cells, required for tumor infiltration and activation of T-cells expressing the lymphotoxin LTA:LTB heterotrimer thus promoting tumor malignant progression (By similarity). Also reported to limit proliferation of T-cells (PubMed:18277947). Released HMGB1:nucleosome complexes formed during apoptosis can signal through TLR2 to induce cytokine production. Involved in induction of immunological tolerance by apoptotic cells; its pro-inflammatory activities when released by apoptotic cells are neutralized by reactive oxygen species (ROS)-dependent oxidation specifically on Cys-106 (By similarity). During macrophage activation by activated lymphocyte-derived self apoptotic DNA (ALD-DNA) promotes recruitment of ALD-DNA to endosomes (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Influences of microRNA-451 on the expression of HMGB1 in myocardial cells and its mechanism in ischemia-reperfusion injury. Publication Status: Online-Only, [RefSeq, PubMed]; METTL3 mediated ferroptosis in chondrocytes and promoted pain in KOA via HMGB1 m6A modification., [RefSeq, PubMed]; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as a sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as a danger-associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury. Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors. In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance (PubMed:23446148, PubMed:23519706, PubMed:23994764, PubMed:25048472). Has proangiogenic activity. May be involved in platelet activation. Binds to phosphatidylserine and phosphatidylethanolamide (PubMed:11154118). Bound to RAGE mediates signaling for neuronal outgrowth (PubMed:12183440, PubMed:1885601, PubMed:2461949, PubMed:7592757). May play a role in accumulation of expanded polyglutamine (polyQ) proteins., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, UniProtKB, PubMed]; Nuclear functions are attributed to fully reduced HGMB1. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA, DNA-containing cruciforms or bent structures, supercoiled DNA and ZDNA (PubMed:11513603, PubMed:2922595). Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:12486007). May be involved in nucleotide excision repair (NER), mismatch repair (MMR) and base excision repair (BER) pathways, and double strand break repair such as non-homologous end joining (NHEJ) (PubMed:10866811). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). In vitro can displace histone H1 from highly bent DNA (PubMed:24551219). Can restructure the canonical nucleosome leading to relaxation of structural constraints for transcription factor-binding (By similarity). Enhances binding of sterol regulatory element-binding proteins (SREBPs) such as SREBF1 to their cognate DNA sequences and increases their transcriptional activities (By similarity). Facilitates binding of TP53 to DNA (By similarity). May be involved in mitochondrial quality control and autophagy in a transcription-dependent fashion implicating HSPB1 (By similarity). Can modulate the activity of the telomerase complex and may be involved in telomere maintenance (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, UniProtKB]; Suppression of microRNA-320 Induces Cerebral Protection Against Ischemia/Reperfusion Injury by Targeting HMGB1/NF-kappaB Axis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 11, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P07155;P27109;P27428;Q548R9", "ec_number_list": [], "go_molecular_function": "GO:0010858 calcium-dependent protein kinase regulator activity;GO:0003681 bent DNA binding;GO:0008301 DNA binding, bending;GO:0050786 RAGE receptor binding;GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005769 early endosome", "go_biological_process": "GO:0002270 plasmacytoid dendritic cell activation;GO:0002643 regulation of tolerance induction;GO:0002840 regulation of T cell mediated immune response to tumor cell;GO:0017055 negative regulation of RNA polymerase II transcription preinitiation complex assembly;GO:0032425 positive regulation of mismatch repair", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "P63159-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62656-1", "uniprot_id": [ { "id": "PTPRZ_RAT", "url": "https://www.uniprot.org/uniprot/Q62656", "type": "external" } ], "mass": 255342.0, "length": 2316, "protein_name": "Receptor-type tyrosine-protein phosphatase zeta", "gene_name": "Ptprz1", "organism": "Rat", "refseq_name": "receptor-type tyrosine-protein phosphatase zeta isoform 2 precursor", "refseq_ac": [ { "id": "NP_001164156", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164156", "type": "external" } ], "gene_names_uniprotkb": "Ptprz1; Ptprz; Ptpz", "gene_names_refseq": "PTPzeta-A; PTPzeta-B; PTPzeta-S; Ptprz1; Ptpz; RPTPbeta", "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase zeta; 3.1.3.48; 3F8 chondroitin sulfate proteoglycan; 3H1 keratan sulfate proteoglycan; Phosphacan; R-PTP-zeta", "protein_names_refseq": "3F8 chondroitin sulfate proteoglycan; 3H1 keratan sulfate proteoglycan; 6B4 proteoglycan; PTP zeta; R-PTP-zeta; protein tyrosine phosphatase, receptor-type, Z polypeptide 1; receptor-type tyrosine-protein phosphatase zeta isoform 2 precursor; receptor-type tyrosine-protein phosphatase zeta", "tax_id": 10116, "disease": "status epilepticus (Disease Ontology:DOID:1824); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); temporal lobe epilepsy (Disease Ontology:DOID:3328); middle cerebral artery infarction (Disease Ontology:DOID:3525); gastric adenocarcinoma (Disease Ontology:DOID:3717)", "pathway": " (rno:25613); (R-RNO-449836); (R-RNO-9851151)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10212223;16814777;22673903;26857455;27374750;28717188;38843836;7511813;7512960;7528221;7579589;7628014", "class_list": "", "function": "High PTPRZ1 expression is associated with glioblastoma. Publication Status: Online-Only, [RefSeq, PubMed]; Isoform 3 (phosphacan), previously designated 3F8 chondroitin sulfate proteoglycan or 3H1 keratan sulfate proteoglycan depending on the glycosylation status, is a soluble nervous tissue-specific proteoglycan. It is synthesized by glia and binds to neurons and to the neural cell adhesion molecules tenascin, N-CAM or NG-CAM but not to laminin and fibronectin. Phosphacan acts as a potent inhibitor of cell adhesion and neurite outgrowth., [UniProtKB]; Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Tenascin-C and phosphacan represent early indicators of neurodegeneration., [RefSeq, PubMed]; The intracellular delivery of SCB4380 by liposome carriers inhibited PTPRZ activity in C6 glioblastoma cells, and thereby suppressed their migration and proliferation in vitro and tumor growth in a rat allograft model. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 23, "predicted_n_glycosites": 17, "predicted_o_glycosites": 6, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 23, "binding_glycan_count": 0, "secondary_ac_list": "Q62621", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" } ], "go_molecular_function": "GO:0005178 integrin binding;GO:0017134 fibroblast growth factor binding;GO:0016791 phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0030027 lamellipodium;GO:0030424 axon", "go_biological_process": "GO:0035335 peptidyl-tyrosine dephosphorylation;GO:0007165 signal transduction;GO:0007409 axonogenesis;GO:0007611 learning or memory;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q62656-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16884-1", "uniprot_id": [ { "id": "NFH_RAT", "url": "https://www.uniprot.org/uniprot/P16884", "type": "external" } ], "mass": 115378.0, "length": 1072, "protein_name": "Neurofilament heavy polypeptide", "gene_name": "Nefh", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Nefh; Nfh", "gene_names_refseq": "", "protein_names_uniprotkb": "Neurofilament heavy polypeptide; 200 kDa neurofilament protein; NF-H; Neurofilament triplet H protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "autoimmune optic neuritis (Disease Ontology:DOID:0040089); congenital hypothyroidism (Disease Ontology:DOID:0050328); amyotrophic lateral sclerosis type 1 (Disease Ontology:DOID:0060193); Charcot-Marie-Tooth disease axonal type 2CC (Disease Ontology:DOID:0110180); sciatic neuropathy (Disease Ontology:DOID:11446); Creutzfeldt-Jakob disease (Disease Ontology:DOID:11949); optic neuritis (Disease Ontology:DOID:1210); hypothyroidism (Disease Ontology:DOID:1459); glaucoma (Disease Ontology:DOID:1686); status epilepticus (Disease Ontology:DOID:1824); transient cerebral ischemia (Disease Ontology:DOID:224); multiple sclerosis (Disease Ontology:DOID:2377); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); monoclonal gammopathy of uncertain significance (Disease Ontology:DOID:7442); epilepsy with generalized tonic-clonic seizures (Disease Ontology:DOID:7725); neuromyelitis optica (Disease Ontology:DOID:8869); phenylketonuria (Disease Ontology:DOID:9281)", "pathway": " (rno:24587)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "19913522;2230956;22673903;2457365;2878828;2928342;3143606;8702840;9388258;9592082", "class_list": "", "function": "Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NEF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 104, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 18, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O35482;Q540Z7;Q63368", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0015643 toxic substance binding;GO:0019901 protein kinase binding;GO:0030674 protein-macromolecule adaptor activity;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0014069 postsynaptic density;GO:0030424 axon;GO:0043025 neuronal cell body", "go_biological_process": "GO:0045110 intermediate filament bundle assembly;GO:0048936 peripheral nervous system neuron axonogenesis;GO:0021510 spinal cord development;GO:0031175 neuron projection development;GO:0021766 hippocampus development", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P16884-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZC4-1", "uniprot_id": [ { "id": "PCY1B_RAT", "url": "https://www.uniprot.org/uniprot/Q9QZC4", "type": "external" } ], "mass": 41900.0, "length": 369, "protein_name": "Choline-phosphate cytidylyltransferase B", "gene_name": "AABR07038849.1; Pcyt1b", "organism": "Rat", "refseq_name": "choline-phosphate cytidylyltransferase B", "refseq_ac": [ { "id": "NP_775174", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775174", "type": "external" } ], "gene_names_uniprotkb": "AABR07038849.1; Pcyt1b; AABR07038849.1; Cctb; Pcyt1b", "gene_names_refseq": "CCT-beta; CTB; Cctbeta; Pcyt1b", "protein_names_uniprotkb": "Choline-phosphate cytidylyltransferase B; 2.7.7.15; CCT B; CCT-beta; CT B; CTP:phosphocholine cytidylyltransferase B; Phosphorylcholine transferase B", "protein_names_refseq": "CCT B; CT B; CTP:phosphocholine cytidylyltransferase B; choline phosphate cytidylyltransferase 1 beta; choline-phosphate cytidylyltransferase B; phosphate cytidylyltransferase 1, choline, beta; phosphorylcholine transferase B", "tax_id": 10116, "disease": "", "pathway": " (rno:286936); (R-RNO-1483191)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "12114961;17981805;19783652;22673903", "class_list": "", "function": "Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results highlight the importance of CTbeta2 in neurons for promoting neurite outgrowth and branching and represent the first identification of a lipid biosynthetic enzyme that facilitates these functions., [RefSeq, PubMed]; The 2.2-A structure reveals a CCT236 homodimer in complex with the reaction product, CDP-choline., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.7.15", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.15", "type": "external" } ], "go_molecular_function": "GO:0004105 choline-phosphate cytidylyltransferase activity;GO:0031210 phosphatidylcholine binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0006657 CDP-choline pathway;GO:0007283 spermatogenesis;GO:0006656 phosphatidylcholine biosynthetic process;GO:0001541 ovarian follicle development;GO:1904116 response to vasopressin", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9QZC4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21555-1", "uniprot_id": [ { "id": "NPY1R_RAT", "url": "https://www.uniprot.org/uniprot/P21555", "type": "external" } ], "mass": 44117.0, "length": 382, "protein_name": "Neuropeptide Y receptor type 1", "gene_name": "Npy1r", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Npy1r", "gene_names_refseq": "", "protein_names_uniprotkb": "Neuropeptide Y receptor type 1; FC5; NPY1-R", "protein_names_refseq": "", "tax_id": 10116, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); peripheral artery disease (Disease Ontology:DOID:0050830); stroke (Disease Ontology:DOID:0051061); absence epilepsy (Disease Ontology:DOID:0070309); hypertension (Disease Ontology:DOID:10763); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); anxiety disorder (Disease Ontology:DOID:2030); opiate dependence (Disease Ontology:DOID:2559); temporal lobe epilepsy (Disease Ontology:DOID:3328); amphetamine abuse (Disease Ontology:DOID:670); cocaine abuse (Disease Ontology:DOID:809); obesity (Disease Ontology:DOID:9970); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:29358); (R-RNO-375276); (R-RNO-418594)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "2172008;22673903", "class_list": "", "function": "Receptor for neuropeptide Y (NPY) and peptide YY (PYY). Can also bind with high affinity [Leu-31, Pro-34]NPY, an analog of NPY modified at residues 31 and 34 of the mature form, while having virtually no affinity for pancreatic polypeptide (PP/PPY) at physiological concentrations. NPY or PYY binding induces adenylate cyclase-inhibiting G protein-coupled receptor signaling, resulting in inhibition of cAMP production. Receptor activation by ligands also leads to an increase of intracellular Ca(2+) levels. As a receptor for NPY, it is involved in the regulation of eating behaviour and NPY-induced stimulation of food intake (By similarity). Involved in the regulation of colonic antisecretory tone, and colonic contractility (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004983 neuropeptide Y receptor activity;GO:0001601 peptide YY receptor activity;GO:0001602 pancreatic polypeptide receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098992 neuronal dense core vesicle;GO:0005886 plasma membrane;GO:0030424 axon;GO:0043005 neuron projection", "go_biological_process": "GO:0030432 peristalsis;GO:0007218 neuropeptide signaling pathway;GO:0007626 locomotory behavior;GO:0040014 regulation of multicellular organism growth;GO:0045471 response to ethanol", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P21555-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97838-1", "uniprot_id": [ { "id": "DLGP3_RAT", "url": "https://www.uniprot.org/uniprot/P97838", "type": "external" } ], "mass": 105990.0, "length": 977, "protein_name": "Disks large-associated protein 3", "gene_name": "Dlgap3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Dlgap3; Dap3", "gene_names_refseq": "", "protein_names_uniprotkb": "Disks large-associated protein 3; DAP-3; PSD-95/SAP90-binding protein 3; SAP90/PSD-95-associated protein 3; SAPAP3", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-6794361)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15207911;22673903;29393594;9115257", "class_list": "", "function": "May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6QQA8;Q6QQA9", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019904 protein domain specific binding;GO:0001540 amyloid-beta binding;GO:0030165 PDZ domain binding;GO:0097110 scaffold protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0031594 neuromuscular junction;GO:0043025 neuronal cell body", "go_biological_process": "GO:0050804 modulation of chemical synaptic transmission;GO:0023052 signaling;GO:0065003 protein-containing complex assembly;GO:0099010 modification of postsynaptic structure", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P97838-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08628-1", "uniprot_id": [ { "id": "PCOC1_RAT", "url": "https://www.uniprot.org/uniprot/O08628", "type": "external" } ], "mass": 50185.0, "length": 468, "protein_name": "Procollagen C-endopeptidase enhancer 1", "gene_name": "Pcolce", "organism": "Rat", "refseq_name": "procollagen C-endopeptidase enhancer 1 precursor", "refseq_ac": [ { "id": "NP_062110", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062110", "type": "external" } ], "gene_names_uniprotkb": "Pcolce; Pcpe1", "gene_names_refseq": "PCPE; Pcolce", "protein_names_uniprotkb": "Procollagen C-endopeptidase enhancer 1; PCPE-1; Procollagen C-proteinase enhancer 1; Procollagen COOH-terminal proteinase enhancer 1; Type 1 procollagen C-proteinase enhancer protein; Type I procollagen COOH-terminal proteinase enhancer", "protein_names_refseq": "PCPE-1; procollagen C-endopeptidase enhancer 1 precursor; procollagen C-endopeptidase enhancer 1; procollagen C-endopeptidase enhancer protein; procollagen C-proteinase enhancer 1; procollagen C-proteinase enhancer protein; procollagen COOH-terminal proteinase enhancer 1; type 1 procollagen C-proteinase enhancer protein; type I procollagen COOH-terminal proteinase enhancer", "tax_id": 10116, "disease": "", "pathway": " (rno:29569); (R-RNO-1650814); (R-RNO-2243919)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "11798157;16641100;2256940;9303490", "class_list": "", "function": "Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity., [UniProtKB]; Role in stabilization of RNA in noncollagenous protein synthesis as well as collagen synthesis in hepatic stellate cells, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0016504 peptidase activator activity;GO:0005518 collagen binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis;GO:1990830 cellular response to leukemia inhibitory factor", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O08628-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P14659-1", "uniprot_id": [ { "id": "HSP72_RAT", "url": "https://www.uniprot.org/uniprot/P14659", "type": "external" } ], "mass": 69642.0, "length": 633, "protein_name": "Heat shock-related 70 kDa protein 2", "gene_name": "Hspa2", "organism": "Rat", "refseq_name": "heat shock-related 70 kDa protein 2", "refseq_ac": [ { "id": "NP_068635", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068635", "type": "external" } ], "gene_names_uniprotkb": "Hspa2; Hst70", "gene_names_refseq": "Hspa2; Hspt70; Hst70", "protein_names_uniprotkb": "Heat shock-related 70 kDa protein 2; HST; Heat shock protein 70.2; Testis-specific heat shock protein-related", "protein_names_refseq": "HST; heat shock 70kDa protein 2; heat shock protein 2; heat shock protein 70.2; heat shock protein alpha 2; heat shock protein family A member 2; heat shock-related 70 kDa protein 2; testis-specific heat shock protein-related gene hst70", "tax_id": 10116, "disease": "", "pathway": " (rno:60460); (R-RNO-3371453); (R-RNO-3371497); (R-RNO-3371568); (R-RNO-9833482)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "16641100;1688714;22673903;25043441", "class_list": "", "function": "HSPA2 abundance increased whereas ubiquitin expression reduced in the affected testis of a rat varicocele model., [RefSeq, PubMed]; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. Plays a role in spermatogenesis. In association with SHCBP1L may participate in the maintenance of spindle integrity during meiosis in male germ cells., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q66HL1", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0036128 CatSper complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0090084 negative regulation of inclusion body assembly;GO:0001934 positive regulation of protein phosphorylation;GO:0007283 spermatogenesis;GO:0009409 response to cold;GO:0010971 positive regulation of G2/M transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P14659-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17712-1", "uniprot_id": [ { "id": "HXK4_RAT", "url": "https://www.uniprot.org/uniprot/P17712", "type": "external" } ], "mass": 52116.0, "length": 465, "protein_name": "Hexokinase-4", "gene_name": "Gck", "organism": "Rat", "refseq_name": "hexokinase-4 isoform 3", "refseq_ac": [ { "id": "NP_001257779", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257779", "type": "external" } ], "gene_names_uniprotkb": "Gck", "gene_names_refseq": "GLK; GLUKA; Gck; RNGK2", "protein_names_uniprotkb": "Hexokinase-4; 2.7.1.1; Glucokinase; HK IV; HK4; Hexokinase type IV; Hexokinase-D", "protein_names_refseq": "HK IV; HK4; hexokinase type IV; hexokinase-4 isoform 3; hexokinase-4; hexokinase-D", "tax_id": 10116, "disease": "maturity-onset diabetes of the young (Disease Ontology:DOID:0050524); permanent neonatal diabetes mellitus (Disease Ontology:DOID:0060639); familial hyperinsulinemic hypoglycemia 3 (Disease Ontology:DOID:0070216); maturity-onset diabetes of the young type 2 (Disease Ontology:DOID:0111100); hypertension (Disease Ontology:DOID:10763); gestational diabetes (Disease Ontology:DOID:11714); neonatal diabetes mellitus (Disease Ontology:DOID:11717); hyperinsulinemic hypoglycemia (Disease Ontology:DOID:13317); hyperinsulinism (Disease Ontology:DOID:2018); coronary artery disease (Disease Ontology:DOID:3393); glucose metabolism disease (Disease Ontology:DOID:4194); hyperglycemia (Disease Ontology:DOID:4195); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (rno:24385); (R-RNO-170822); (R-RNO-70171)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10456334;12513690;16542652;1999433;2396986;24187134;2550428;2590200;2662183;2909525;32188779;3515342;37093431;38875221;6477520", "class_list": "", "function": "BMAL1 Regulates Glucokinase Expression Through E-Box Elements In Vitro., [RefSeq, PubMed]; Catalyzes the phosphorylation of hexose, such as D-glucose, D-fructose and D-mannose, to hexose 6-phosphate (D-glucose 6-phosphate, D-fructose 6-phosphate and D-mannose 6-phosphate, respectively) (PubMed:12513690, PubMed:24187134, PubMed:6477520). Compared to other hexokinases, has a weak affinity for D-glucose, and is effective only when glucose is abundant (PubMed:6477520). Mainly expressed in pancreatic beta cells and the liver and constitutes a rate-limiting step in glucose metabolism in these tissues (By similarity). Since insulin secretion parallels glucose metabolism and the low glucose affinity of GCK ensures that it can change its enzymatic activity within the physiological range of glucose concentrations, GCK acts as a glucose sensor in the pancreatic beta cell (By similarity). In pancreas, plays an important role in modulating insulin secretion (By similarity). In liver, helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage (By similarity). Required to provide D-glucose 6-phosphate for the synthesis of glycogen (By similarity). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:12513690, PubMed:6477520)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; NGF effects promote the maturation of rat pancreatic beta cells by regulating GLUT2 levels and distribution, and glucokinase activity. Publication Status: Online-Only, [RefSeq, PubMed]; Study in different rat models demonstrated that glucokinase (GCK)-mediated glucose phosphorylation is the rate-controlling step in insulin-stimulated hepatic glycogen synthesis in vivo under both normal and pathophysiological conditions of fatty liver-associated hepatic insulin resistance and it is controlled chiefly through GCK translocation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 17, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P17711", "ec_number_list": [ { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" } ], "go_molecular_function": "GO:0004340 glucokinase activity;GO:0008865 fructokinase activity;GO:0019158 mannokinase activity;GO:0000287 magnesium ion binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0045180 basal cortex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006739 NADP+ metabolic process;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0032024 positive regulation of insulin secretion;GO:0032869 cellular response to insulin stimulus;GO:0055088 lipid homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P17712-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27605-1", "uniprot_id": [ { "id": "HPRT_RAT", "url": "https://www.uniprot.org/uniprot/P27605", "type": "external" } ], "mass": 24477.0, "length": 218, "protein_name": "Hypoxanthine-guanine phosphoribosyltransferase", "gene_name": "Hprt1", "organism": "Rat", "refseq_name": "hypoxanthine-guanine phosphoribosyltransferase", "refseq_ac": [ { "id": "NP_036715", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036715", "type": "external" } ], "gene_names_uniprotkb": "Hprt1; Hprt", "gene_names_refseq": "Hgprtase; Hprt1; Hprt", "protein_names_uniprotkb": "Hypoxanthine-guanine phosphoribosyltransferase; 2.4.2.8; HGPRTase; HGPRT", "protein_names_refseq": "HGPRT; hypoxanthine guanine phosphoribosyl transferase 1; hypoxanthine phosphoribosyl transferase; hypoxanthine-guanine phosphoribosyltransferase", "tax_id": 10116, "disease": "HRPT-related hyperuricemia (Disease Ontology:DOID:0112127); Lesch-Nyhan syndrome (Disease Ontology:DOID:1919); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:24465); (R-RNO-74217); (R-RNO-9748787)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "1373820;1781355;1783384;22673903;25047350;25187167;32875725;7526167;9691986", "class_list": "", "function": "Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway., [UniProtKB, UniProtKB, UniProtKB]; Report frequency of phenacetin induced gtp point mutations in the liver and kidney of gpt transgenic rats., [RefSeq, PubMed]; The combination of hprt and gapdh is the best compound reference genes in the fetal rat hippocampus., [RefSeq, PubMed]; Thsi study validated the Hprt1, Actb, Mapk6 or B2m and showed that any one or combination of two of them are good reference genes for normalization of mRNA expression in qPCR experiments in the spinal cord and RVM in the CFA model of inflammatory injury. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P70469;Q4KMC5;Q62926", "ec_number_list": [ { "id": "2.4.2.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.8", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0042802 identical protein binding;GO:0000166 nucleotide binding;GO:0004422 hypoxanthine phosphoribosyltransferase activity;GO:0052657 guanine phosphoribosyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007626 locomotory behavior;GO:0032869 cellular response to insulin stimulus;GO:0051289 protein homotetramerization;GO:0001975 response to amphetamine", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P27605-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46462-1", "uniprot_id": [ { "id": "TERA_RAT", "url": "https://www.uniprot.org/uniprot/P46462", "type": "external" } ], "mass": 89349.0, "length": 806, "protein_name": "Transitional endoplasmic reticulum ATPase", "gene_name": "Vcp", "organism": "Rat", "refseq_name": "transitional endoplasmic reticulum ATPase", "refseq_ac": [ { "id": "NP_446316", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446316", "type": "external" } ], "gene_names_uniprotkb": "Vcp", "gene_names_refseq": "Vcp", "protein_names_uniprotkb": "Transitional endoplasmic reticulum ATPase; 15S Mg(2+)-ATPase p97 subunit; 3.6.4.6; TER ATPase; VCP; Valosin-containing protein", "protein_names_refseq": "15S Mg(2+)-ATPase p97 subunit; TER ATPase; transitional endoplasmic reticulum ATPase", "tax_id": 10116, "disease": "inclusion body myopathy with Paget disease of bone and frontotemporal dementia (Disease Ontology:DOID:0050881); frontotemporal dementia and/or amyotrophic lateral sclerosis 6 (Disease Ontology:DOID:0060205); Charcot-Marie-Tooth disease type 2Y (Disease Ontology:DOID:0110168); inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1 (Disease Ontology:DOID:0111385); neurodegenerative disease (Disease Ontology:DOID:1289); dementia (Disease Ontology:DOID:1307); inclusion body myositis (Disease Ontology:DOID:3429); Paget's disease of bone (Disease Ontology:DOID:5408); primary ovarian insufficiency (Disease Ontology:DOID:5426); frontotemporal dementia (Disease Ontology:DOID:9255)", "pathway": " (rno:116643); (R-RNO-110320); (R-RNO-3371511); (R-RNO-382556); (R-RNO-532668); (R-RNO-5358346); (R-RNO-5689877); (R-RNO-5689896); (R-RNO-6798695); (R-RNO-8951664); (R-RNO-9013407); (R-RNO-9755511); (R-RNO-9931269)", "pathway_count": 13, "publication_count": 16, "publication_id_list": "10811609;10930451;12146947;12411482;12473691;12810701;16027165;18047804;18683930;22673903;26265139;28799247;34502162;36843060;7806566;9506515", "class_list": "", "function": "Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER) (PubMed:10930451, PubMed:12411482). Vesicle budding from the tER is an ATP-dependent process (PubMed:10930451, PubMed:12411482). The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome (PubMed:10930451, PubMed:12411482). The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Mediates the endoplasmic reticulum-associated degradation of CHRNA3 in cortical neurons as part of the STUB1-VCP-UBXN2A complex (PubMed:26265139). Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. Involved in clearance process by mediating G3BP1 extraction from stress granules (By similarity). Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites. Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage. Together with SPRTN metalloprotease, involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis. Involved in interstrand cross-link repair in response to replication stress by mediating unloading of the ubiquitinated CMG helicase complex. Mediates extraction of PARP1 trapped to chromatin: recognizes and binds ubiquitinated PARP1 and promotes its removal (By similarity). Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation. Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy. Acts as a negative regulator of type I interferon production by interacting with RIGI: interaction takes place when RIGI is ubiquitinated via 'Lys-63'-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of RIGI (By similarity). May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation (By similarity). May more particularly play a role in caveolins sorting in cells (By similarity). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, PubMed]; The immunoexpression of valosin-containing protein and small VCP-interacting protein in rat ovaries., [RefSeq, PubMed]; Valosin-containing protein is a novel repressor of cardiomyocyte hypertrophy induced by pressure overload., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "1.11.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.5.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.5.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.52", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "2.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.13", "type": "external" } ], "go_molecular_function": "GO:0036435 K48-linked polyubiquitin modification-dependent protein binding;GO:0140036 ubiquitin-modified protein reader activity;GO:0005524 ATP binding;GO:0019904 protein domain specific binding;GO:0031593 polyubiquitin modification-dependent protein binding", "go_cellular_component": "GO:1990730 VCP-NSFL1C complex;GO:0098978 glutamatergic synapse;GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex;GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0097352 autophagosome maturation;GO:2001171 positive regulation of ATP biosynthetic process;GO:1903006 positive regulation of protein K63-linked deubiquitination;GO:0043335 protein unfolding;GO:1905634 regulation of protein localization to chromatin", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P46462-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70507-1", "uniprot_id": [ { "id": "GRK4_RAT", "url": "https://www.uniprot.org/uniprot/P70507", "type": "external" } ], "mass": 66788.0, "length": 575, "protein_name": "G protein-coupled receptor kinase 4", "gene_name": "Grk4", "organism": "Rat", "refseq_name": "G protein-coupled receptor kinase 4 isoform 1", "refseq_ac": [ { "id": "NP_075217", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075217", "type": "external" } ], "gene_names_uniprotkb": "Grk4; Gprk2l", "gene_names_refseq": "Gprk2l; Grk4", "protein_names_uniprotkb": "G protein-coupled receptor kinase 4; 2.7.11.16; G protein-coupled receptor kinase GRK4", "protein_names_refseq": "G protein-coupled receptor kinase 2, groucho gene related; G protein-coupled receptor kinase 4 isoform 1; g protein-coupled receptor kinase GRK4", "tax_id": 10116, "disease": "essential hypertension (Disease Ontology:DOID:10825); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (rno:59077); (R-RNO-2514859)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "16636192;22673903;23839509;32687659;32940654;9607785", "class_list": "", "function": "Buffalo colostrum beta-lactoglobulin inhibits VEGF-induced angiogenesis by interacting with G protein-coupled receptor kinase, [RefSeq, PubMed]; GRK4-mediated adiponectin receptor-1 phosphorylative desensitization as a novel mechanism of reduced renal sodium excretion in hypertension., [RefSeq, PubMed]; Role of GRK4 in the regulation of the renal ETB receptor in hypertension. Erratum:[FASEB J. 2021 Apr;35(4):e21429. doi: 10.1096/fsb2.21429. PMID: 33734484], [RefSeq, PubMed]; Specifically phosphorylates the activated forms of G protein-coupled receptors. Plays an important role in the regulation of renal sodium handling and blood pressure., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P70508", "ec_number_list": [ { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.15", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.15", "type": "external" }, { "id": "2.7.11.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.16", "type": "external" }, { "id": "2.7.11.14", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.14", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0050254 rhodopsin kinase activity;GO:0004703 G protein-coupled receptor kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005938 cell cortex;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007165 signal transduction;GO:0031623 receptor internalization;GO:0002031 G protein-coupled receptor internalization;GO:0009966 regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P70507-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P80299-1", "uniprot_id": [ { "id": "HYES_RAT", "url": "https://www.uniprot.org/uniprot/P80299", "type": "external" } ], "mass": 62340.0, "length": 554, "protein_name": "Bifunctional epoxide hydrolase 2", "gene_name": "Ephx2", "organism": "Rat", "refseq_name": "bifunctional epoxide hydrolase 2", "refseq_ac": [ { "id": "NP_075225", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075225", "type": "external" } ], "gene_names_uniprotkb": "Ephx2", "gene_names_refseq": "Ephx2", "protein_names_uniprotkb": "Bifunctional epoxide hydrolase 2; Epoxide hydratase; SEH; Soluble epoxide hydrolase", "protein_names_refseq": "CEH; SEH; bifunctional epoxide hydrolase 2; cytosolic epoxide hydrolase; epoxide hydratase; epoxide hydrolase 2, cytoplasmic; soluble epoxide hydrolase", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061); hypertension (Disease Ontology:DOID:10763); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); familial hypercholesterolemia (Disease Ontology:DOID:13810); coronary artery disease (Disease Ontology:DOID:3393); cerebral infarction (Disease Ontology:DOID:3526); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (rno:65030); (R-RNO-2142670); (R-RNO-9018682); (R-RNO-9033241)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "12574508;1743286;21217101;30950936;32767848;36585106;36669577;38013165;8349641;8626766", "class_list": "", "function": "Bifunctional enzyme (PubMed:12574508, PubMed:8626766). The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides (PubMed:8626766). Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides (PubMed:8626766). Also determines steady-state levels of physiological mediators (By similarity). The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid and 12-phosphonooxy-octadec-9E-enoic acid (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; Bifunctional enzyme (PubMed:12574508, PubMed:8626766). The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid and 12-phosphonooxy-octadec-9E-enoic acid (PubMed:12574508). Has phosphatase activity toward lyso-glycerophospholipids with also some lower activity toward lysolipids of sphingolipid and isoprenoid phosphates (By similarity)., [UniProtKB, PubMed, UniProtKB]; Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Bifunctional enzyme. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid and 12-phosphonooxy-octadec-9E-enoic acid. Has phosphatase activity toward lyso-glycerophospholipids with also some lower activity toward lysolipids of sphingolipid and isoprenoid phosphates., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; CRISPR/Cas9-mediated inactivation of the phosphatase activity of soluble epoxide hydrolase prevents obesity and cardiac ischemic injury., [RefSeq, PubMed]; Role of soluble epoxide hydrolase in the abnormal activation of fibroblast-like synoviocytes from patients with rheumatoid arthritis., [RefSeq, PubMed]; Soluble epoxide hydrolase and TRPC3 channels jointly contribute to homocysteine-induced cardiac hypertrophy: Interrelation and regulation by C/EBPbeta., [RefSeq, PubMed]; Soluble epoxide hydrolase inhibition improves cognitive function and parenchymal artery dilation in a hypertensive model of chronic cerebral hypoperfusion., [RefSeq, PubMed]; Study shows that inhibition of soluble epoxide hydrolase regulates monocyte/macrophage polarization and improves neurological outcome in a rat model of ischemic stroke, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 18, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.4", "type": "external" }, { "id": "3.6.1.75", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.75", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.106", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.106", "type": "external" }, { "id": "3.3.2.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.9", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.3.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.10", "type": "external" }, { "id": "3.1.3.76", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.76", "type": "external" } ], "go_molecular_function": "GO:0052642 lysophosphatidic acid phosphatase activity;GO:0000287 magnesium ion binding;GO:0015643 toxic substance binding;GO:0042803 protein homodimerization activity;GO:0004301 epoxide hydrolase activity", "go_cellular_component": "GO:0005777 peroxisome;GO:0005829 cytosol", "go_biological_process": "GO:1904681 response to 3-methylcholanthrene;GO:0016311 dephosphorylation;GO:0010628 positive regulation of gene expression;GO:0045777 positive regulation of blood pressure;GO:0090181 regulation of cholesterol metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P80299-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q04753-1", "uniprot_id": [ { "id": "ICLN_RAT", "url": "https://www.uniprot.org/uniprot/Q04753", "type": "external" } ], "mass": 26092.0, "length": 236, "protein_name": "Methylosome subunit pICln", "gene_name": "Clns1a", "organism": "Rat", "refseq_name": "methylosome subunit pICln", "refseq_ac": [ { "id": "NP_113907", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113907", "type": "external" } ], "gene_names_uniprotkb": "Clns1a; Icln; Rcl1", "gene_names_refseq": "Clci; Clcni; Clns1a; Icln; pICln", "protein_names_uniprotkb": "Methylosome subunit pICln; Chloride channel, nucleotide sensitive 1A; Chloride conductance regulatory protein ICln; I(Cln)", "protein_names_refseq": "Clns 1a; chloride channel current inducer; chloride channel, nucleotide-sensitive, 1A; chloride conductance regulatory protein ICln; i(Cln); methylosome subunit pICln", "tax_id": 10116, "disease": "", "pathway": " (rno:65160); (R-RNO-191859)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "12970357;22673903;7683461;8313467;8391324", "class_list": "", "function": "ICln associates with the cell membrane after cell swelling, [RefSeq, PubMed]; Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins (By similarity). Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (By similarity). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (By similarity). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (By similarity). Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus (By similarity)., [UniProtKB, UniProtKB]; Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins. Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding;GO:0005267 potassium channel activity;GO:0005229 intracellularly calcium-gated chloride channel activity;GO:0036094 small molecule binding;GO:1990935 splicing factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006884 cell volume homeostasis;GO:0006821 chloride transport;GO:0000387 spliceosomal snRNP assembly;GO:0045292 mRNA cis splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q04753-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07008-1", "uniprot_id": [ { "id": "NOTC1_RAT", "url": "https://www.uniprot.org/uniprot/Q07008", "type": "external" } ], "mass": 270822.0, "length": 2531, "protein_name": "Neurogenic locus notch homolog protein 1", "gene_name": "Notch1", "organism": "Rat", "refseq_name": "neurogenic locus notch homolog protein 1 precursor", "refseq_ac": [ { "id": "NP_001099191", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099191", "type": "external" } ], "gene_names_uniprotkb": "Notch1", "gene_names_refseq": "NOTCH; Notch1; TAN1", "protein_names_uniprotkb": "Neurogenic locus notch homolog protein 1; Notch 1", "protein_names_refseq": "Drosophila Notch homolog 1 (controlling the the ectodermal and neural cell fate in Drosophila); Notch gene homolog 1; neurogenic locus notch homolog protein 1 precursor; neurogenic locus notch homolog protein 1; notch 1", "tax_id": 10116, "disease": "adult T-cell leukemia/lymphoma (Disease Ontology:DOID:0050523); Adams-Oliver syndrome (Disease Ontology:DOID:0060227); aortic valve disease 1 (Disease Ontology:DOID:0080333); intestinal cancer (Disease Ontology:DOID:10155); neurodegenerative disease (Disease Ontology:DOID:1289); retinopathy of prematurity (Disease Ontology:DOID:13025); brain cancer (Disease Ontology:DOID:1319); endometrial cancer (Disease Ontology:DOID:1380); alcohol use disorder (Disease Ontology:DOID:1574); cancer (Disease Ontology:DOID:162); congenital heart disease (Disease Ontology:DOID:1682); transient cerebral ischemia (Disease Ontology:DOID:224); hemangiopericytoma (Disease Ontology:DOID:264); adenocarcinoma (Disease Ontology:DOID:299); central nervous system cancer (Disease Ontology:DOID:3620); pulmonary fibrosis (Disease Ontology:DOID:3770); lung adenocarcinoma (Disease Ontology:DOID:3910); lung large cell carcinoma (Disease Ontology:DOID:4556); cholangiocarcinoma (Disease Ontology:DOID:4947); lung small cell carcinoma (Disease Ontology:DOID:5409); colorectal cancer (Disease Ontology:DOID:9256); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25496)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11182080;11438922;1295745;1764995;25700513;35545948;36602704;37543138;38418142;38625070", "class_list": "", "function": "Adipose-derived stem cell modulate tolerogenic dendritic cell-induced T cell regulation is correlated with activation of Notch-NFkappaB signaling., [RefSeq, PubMed]; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination (By similarity). Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (By similarity). Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting (By similarity). Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus (By similarity). Important for follicular differentiation and possibly cell fate selection within the follicle (By similarity). During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia (PubMed:11182080). Represses neuronal and myogenic differentiation (By similarity). May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation (By similarity). May be involved in mesoderm development, somite formation and neurogenesis (By similarity). May enhance HIF1A function by sequestering HIF1AN away from HIF1A (By similarity). Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury (By similarity). Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO) (By similarity)., [UniProtKB, UniProtKB, PubMed]; Hypoxia-induced mesenchymal stem cells inhibit corneal fibroblast proliferation by regulating the WWP2/Notch1 axis., [RefSeq, PubMed]; Involvement of NOTCH1-mediated Microglia Activation in Neuromodulation of Chronic Prostatitis-related Pain., [RefSeq, PubMed]; Regulatory role of melatonin in Notch1 signaling pathway in cerebral cortex of Abeta1-42-induced Alzheimer's disease rat model., [RefSeq, PubMed]; The Notch1/Hes1 signaling pathway affects autophagy by adjusting DNA methyltransferases expression in a valproic acid-induced autism spectrum disorder model., [RefSeq, PubMed]", "predicted_glycosites": 43, "predicted_n_glycosites": 7, "predicted_o_glycosites": 36, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 7, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 22, "glyco_site_count": 50, "binding_glycan_count": 0, "secondary_ac_list": "F1M9E7", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0004857 enzyme inhibitor activity;GO:0004888 transmembrane signaling receptor activity;GO:0019899 enzyme binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005856 cytoskeleton", "go_biological_process": "GO:0046533 negative regulation of photoreceptor cell differentiation;GO:0046579 positive regulation of Ras protein signal transduction;GO:0001708 cell fate specification;GO:0045608 negative regulation of inner ear auditory receptor cell differentiation;GO:0048708 astrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q07008-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3B7D0-1", "uniprot_id": [ { "id": "HEM6_RAT", "url": "https://www.uniprot.org/uniprot/Q3B7D0", "type": "external" } ], "mass": 49278.0, "length": 443, "protein_name": "Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial", "gene_name": "Cpox", "organism": "Rat", "refseq_name": "oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001032172", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032172", "type": "external" } ], "gene_names_uniprotkb": "Cpox; Cpo", "gene_names_refseq": "Cpox", "protein_names_uniprotkb": "Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial; 1.3.3.3; COX; Coprogen oxidase; Coproporphyrinogenase", "protein_names_refseq": "COX; coprogen oxidase; coproporphyrinogen-III oxidase, mitochondrial; coproporphyrinogenase; oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial precursor; oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial", "tax_id": 10116, "disease": "hereditary coproporphyria (Disease Ontology:DOID:13269); liver disease (Disease Ontology:DOID:409)", "pathway": " (rno:304024); (R-RNO-189451)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22673903;666752", "class_list": "", "function": "Involved in the heme biosynthesis (PubMed:666752). Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX (PubMed:666752)., [UniProtKB, PubMed]; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.3.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.3", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0005212 structural constituent of eye lens;GO:0004109 coproporphyrinogen oxidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0016020 membrane", "go_biological_process": "GO:0046685 response to arsenic-containing substance;GO:0010288 response to lead ion;GO:0051597 response to methylmercury;GO:0010039 response to iron ion;GO:0006783 heme biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3B7D0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V8H8-1", "uniprot_id": [ { "id": "EHD2_RAT", "url": "https://www.uniprot.org/uniprot/Q4V8H8", "type": "external" } ], "mass": 61237.0, "length": 543, "protein_name": "EH domain-containing protein 2", "gene_name": "Ehd2", "organism": "Rat", "refseq_name": "EH domain-containing protein 2", "refseq_ac": [ { "id": "NP_001020068", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020068", "type": "external" } ], "gene_names_uniprotkb": "Ehd2", "gene_names_refseq": "Ehd2; MGEPS", "protein_names_uniprotkb": "EH domain-containing protein 2", "protein_names_refseq": "EH domain-containing protein 2; putative eps protein", "tax_id": 10116, "disease": "", "pathway": " (rno:361512); (R-RNO-983231)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "14676205;22673903;24664435;29133341;29393594;34502162", "class_list": "", "function": "ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. Plays a role in membrane trafficking between the plasma membrane and endosomes. Important for the internalization of GLUT4. Required for fusion of myoblasts to skeletal muscle myotubes. Required for normal translocation of FER1L5 to the plasma membrane. Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by constraining caveolae at the cell membrane., [UniProtKB, UniProtKB, UniProtKB]; EHD2 expression was upregulated in the perihematomal caudate in adult rats after intracerebral hemorrhage., [RefSeq, PubMed]; EHD2 may be cardioprotective as a dominant-negative EHD2 mutant sensitized cardiomyocytes to ischemic damage. Our findings highlight EHD2 as a potential pharmacologic target in the treatment of diseases with KATP channel trafficking defects, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0016787 hydrolase activity;GO:0019904 protein domain specific binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0072659 protein localization to plasma membrane;GO:0060271 cilium assembly;GO:0030866 cortical actin cytoskeleton organization;GO:2001137 positive regulation of endocytic recycling", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q4V8H8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U2S1-1", "uniprot_id": [ { "id": "NFIP1_RAT", "url": "https://www.uniprot.org/uniprot/Q5U2S1", "type": "external" } ], "mass": 24913.0, "length": 221, "protein_name": "NEDD4 family-interacting protein 1", "gene_name": "Ndfip1", "organism": "Rat", "refseq_name": "NEDD4 family-interacting protein 1", "refseq_ac": [ { "id": "NP_001013077", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013077", "type": "external" } ], "gene_names_uniprotkb": "Ndfip1; N4wbp5", "gene_names_refseq": "Ndfip1", "protein_names_uniprotkb": "NEDD4 family-interacting protein 1", "protein_names_refseq": "NEDD4 family-interacting protein 1", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061)", "pathway": " (rno:291609)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23897647", "class_list": "", "function": "Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents chronic T-helper cell-mediated inflammation by activating ITCH and thus controlling JUNB degradation. Promotes pancreatic beta cell death through degradation of JUNB and inhibition of the unfolded protein response, leading to reduction of insulin secretion. Restricts the production of pro-inflammatory cytokines in effector Th17 T-cells by promoting ITCH-mediated ubiquitination degradation of RORC. Together with NDFIP2, limits the cytokine signaling and expansion of effector Th2 T-cells by promoting degradation of JAK1, probably by ITCH- and NEDD4L-mediated ubiquitination. Regulates peripheral T-cell tolerance to self and foreign antigens, forcing the exit of naive CD4+ T-cells from the cell cycle before they become effector T-cells. Negatively regulates RLR-mediated antiviral response by promoting SMURF1-mediated ubiquitination and subsequent degradation of MAVS. Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus where it mediates KCNH2 degradation. In cortical neurons, mediates the ubiquitination of the divalent metal transporter SLC11A2/DMT1 by NEDD4L, leading to its down-regulation and protection of the cells from cobalt and iron toxicity. Important for normal development of dendrites and dendritic spines in cortex. Enhances the ubiquitination of BRAT1 mediated by: NEDD4, NEDD4L and ITCH and is required for the nuclear localization of ubiquitinated BRAT1. Enhances the ITCH-mediated ubiquitination of MAP3K7 by recruiting E2 ubiquitin-conjugating enzyme UBE2L3 to ITCH. Modulates EGFR signaling through multiple pathways. In particular, may regulate the ratio of AKT1-to-MAPK8 signaling in response to EGF, acting on AKT1 probably through PTEN destabilization and on MAPK8 through ITCH-dependent MAP2K4 inactivation. As a result, may control cell growth rate. Inhibits cell proliferation by promoting PTEN nuclear localization and changing its signaling specificity., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0050699 WW domain binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005938 cell cortex", "go_biological_process": "GO:0007034 vacuolar transport;GO:0048302 regulation of isotype switching to IgG isotypes;GO:0006879 intracellular iron ion homeostasis;GO:0042130 negative regulation of T cell proliferation;GO:0050728 negative regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5U2S1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63035-1", "uniprot_id": [ { "id": "NLRP6_RAT", "url": "https://www.uniprot.org/uniprot/Q63035", "type": "external" } ], "mass": 98324.0, "length": 881, "protein_name": "NACHT, LRR and PYD domains-containing protein 6", "gene_name": "Nlrp6", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Nlrp6; Nalp6; Navr; Pypaf5", "gene_names_refseq": "", "protein_names_uniprotkb": "NACHT, LRR and PYD domains-containing protein 6; Angiotensin II/vasopressin receptor; Non-AVR; Non-angiotensin-vasopressin receptor; PYRIN-containing APAF1-like protein 5-like", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:171390)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11984003;12633874;18413781;21088234;22673903;7489366", "class_list": "", "function": "Acts as the sensor component of the NLRP6 inflammasome, which mediates inflammasome activation in response to various pathogen-associated signals, leading to maturation and secretion of IL1B and IL18. Inflammasomes are supramolecular complexes that assemble in the cytosol in response to pathogens and other damage-associated signals and play critical roles in innate immunity and inflammation. Acts as a recognition receptor (PRR): recognizes and binds specific pathogens and other damage-associated signals, such as lipoteichoic acid (LTA), a cell-wall component of Gram-positive bacteria, or double stranded RNA (dsRNA). May also recognize and bind lipopolysaccharide (LPS), a major component of the outer membrane of Gram-negative bacteria; however, LPS is probably not a major activator of the NLRP6 inflammasome. Following LTA- or dsRNA-binding, NLRP6 undergoes liquid-liquid phase separation (LLPS), enhancing multivalent interactions, an essential step for the formation of the NLRP6 inflammasome polymeric complex. The NLRP6 inflammasome acts by promoting recruitment of effector pro-inflammatory caspases (CASP1 and/or CASP4) that catalyze maturation and secretion of IL1B and IL18 in the extracellular milieu. The NLRP6 inflammasome plays a central role in the maintenance of epithelial integrity and host defense against microbial infections in the intestine. Required to restrict infection against Gram-positive bacteria by recognizing lipoteichoic acid (LTA), leading to recruitment of CASP4 and CASP1, and subsequent maturation and secretion of IL1B and IL18. Involved in intestinal antiviral innate immunity together with DHX15: recognizes and binds viral dsRNA to restrict infection by enteric viruses through the interferon pathway and GSDMD-dependent release of IL18 (By similarity). Required to prevent infection by the apicomplexan parasite Cryptosporidium in enterocytes by promoting GSDMD-dependent release of IL18. The NLRP6 inflammasome may also regulate the gut microbiota composition by acting as a sensor of microbiota-associated metabolites to form a PYCARD/ASC-dependent inflammasome for downstream IL18 release and secretion of antimicrobial peptides. Essential for gut mucosal self-renewal and proliferation. Regulate mucus secretion in an inflammasome- and autophagy-dependent manner to prevent invasion by enteric bacteria,. During systemic bacterial infections, the NLRP6 inflammasome negatively regulates neutrophil recruitment and neutrophil extracellular traps (NETs) formation. May promote peripheral nerve recovery following injury via an inflammasome-independent mechanism (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A5X5C9;D3ZYC0;F1LSH2", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0003725 double-stranded RNA binding;GO:0042277 peptide binding;GO:0035591 signaling adaptor activity;GO:0001530 lipopolysaccharide binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0031965 nuclear membrane;GO:0061702 canonical inflammasome complex", "go_biological_process": "GO:0010506 regulation of autophagy;GO:0050830 defense response to Gram-positive bacterium;GO:0051260 protein homooligomerization;GO:0051607 defense response to virus;GO:0032689 negative regulation of type II interferon production", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q63035-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63190-1", "uniprot_id": [ { "id": "EMD_RAT", "url": "https://www.uniprot.org/uniprot/Q63190", "type": "external" } ], "mass": 29676.0, "length": 260, "protein_name": "Emerin", "gene_name": "Emd", "organism": "Rat", "refseq_name": "emerin", "refseq_ac": [ { "id": "NP_037080", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037080", "type": "external" } ], "gene_names_uniprotkb": "Emd", "gene_names_refseq": "Emd", "protein_names_uniprotkb": "Emerin", "protein_names_refseq": "emerin", "tax_id": 10116, "disease": "X-linked Emery-Dreifuss muscular dystrophy 1 (Disease Ontology:DOID:0070246); Emery-Dreifuss muscular dystrophy (Disease Ontology:DOID:11726); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (rno:25437); (R-RNO-2980766); (R-RNO-2995383); (R-RNO-4419969); (R-RNO-9013149); (R-RNO-9013404); (R-RNO-9013408); (R-RNO-9013423); (R-RNO-9609523)", "pathway_count": 9, "publication_count": 7, "publication_id_list": "16283426;22673903;27114541;28290476;29393594;32926941;9472006", "class_list": "", "function": "Emerin plays a crucial role in nuclear invagination and in the nuclear calcium transient in Emery-Dreifuss muscular dystrophy. Publication Status: Online-Only, [RefSeq, PubMed]; Our findings establish the pathogenetic role of emerin and lamin A/C repression in stretch-induced VSMC proliferation and suggest mechanobiological mechanism underlying this process that involves the sequence-specific binding of emerin and lamin A/C to specific transcription factor motifs., [RefSeq, PubMed]; Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non-farnesylated prelamin-A/C. Together with NEMP1, contributes to nuclear envelope stiffness in germ cells., [UniProtKB, UniProtKB]; Suppressed nuclear envelope proteins activate autophagy of vascular smooth muscle cells during cyclic stretch application., [RefSeq, PubMed]; We now show that epitope masking in the nucleus is often responsible for failure to detect emerin and lamins in human, rat and pig tissues., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0048487 beta-tubulin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0031468 nuclear membrane reassembly;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:1990000 amyloid fibril formation;GO:0046827 positive regulation of protein export from nucleus;GO:0071363 cellular response to growth factor stimulus", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q63190-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63259-1", "uniprot_id": [ { "id": "PTPRN_RAT", "url": "https://www.uniprot.org/uniprot/Q63259", "type": "external" } ], "mass": 106228.0, "length": 983, "protein_name": "Receptor-type tyrosine-protein phosphatase-like N", "gene_name": "Ptprn", "organism": "Rat", "refseq_name": "receptor-type tyrosine-protein phosphatase-like N precursor", "refseq_ac": [ { "id": "NP_446333", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446333", "type": "external" } ], "gene_names_uniprotkb": "Ptprn", "gene_names_refseq": "BEM-3; ICA105; ICA512; Ia-2; PTPLP; Ptprn; R-PTP-N", "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase-like N; 105 kDa islet cell antigen; BEM-3; Brain-enriched membrane-associated protein tyrosine phosphatase; ICA105; ICA512; PTP IA-2; PTPLP; R-PTP-N", "protein_names_refseq": "105 kDa islet cell antigen; brain-enriched membrane-associated protein tyrosine phosphatase; receptor-type tyrosine-protein phosphatase-like N precursor; receptor-type tyrosine-protein phosphatase-like N", "tax_id": 10116, "disease": "Parkinson's disease (Disease Ontology:DOID:14330); diabetes mellitus (Disease Ontology:DOID:9351); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:116660)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10.1039/D0MO00044B;10457160;11483505;15240697;15596545;18178618;22673903;23087044;25561468;30979722;34106099;7568143;7657822;7887886;8641276", "class_list": "", "function": "ICA512-CCF translocated to the nucleus promotes expression of insulin and other granule-related genes; the function implicates binding to and regulating activity of STAT5B probably by preventing its dephosphorylation and potentially by inducing its sumoylation by recruiting PIAS4 (By similarity). Enhances pancreatic beta-cell proliferation by converging with signaling by STAT5B and STAT3 (PubMed:18178618). ICA512-CCF located in the cytoplasm regulates dynamics and exocytosis of insulin secretory granules (SGs) by dimerizing with ICA512-TMF and displacing SNTB2 thus enhancing SGs mobility and exocytosis (By similarity)., [UniProtKB, UniProtKB, PubMed]; ICA512-TMF regulates dynamics and exocytosis of insulin secretory granules (SGs); binding of ICA512-TMF to SNTB2/beta-2-syntrophin is proposed to restrain SGs mobility and exocytosis by tethering them to the actin cytoskeleton depending on UTRN; the function is inhibited by cytoplasmic ICA512-CFF dimerizing with ICA512-TMF and displacing SNTB2 (By similarity)., [UniProtKB, UniProtKB]; In the stomach, IA-2 and IA-2beta were expressed in gastrointestinal endocrine cells that secrete serotonin, somatostatin, and cholecystokinin/gastrin-1., [RefSeq, PubMed]; Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Required to maintain normal levels of renin expression and renin release. Seems to lack intrinsic enzyme activity., [UniProtKB, UniProtKB, UniProtKB]; The ME ICA512 beta2-strand fosters proICA512 dimerization until NTF prevents N506 glycosylation., [RefSeq, PubMed]; These findings point to ICA512 RESP18HD being a condensing factor for protein sorting and granulogenesis early in the secretory pathway and for prevention of amyloidogenesis., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q62883;Q63795;Q64643", "ec_number_list": [], "go_molecular_function": "GO:0030507 spectrin binding;GO:0051020 GTPase binding;GO:0044389 ubiquitin-like protein ligase binding;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0030141 secretory granule", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0032868 response to insulin;GO:0000302 response to reactive oxygen species;GO:0009749 response to glucose", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q63259-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.1000000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63475-1", "uniprot_id": [ { "id": "PTPR2_RAT", "url": "https://www.uniprot.org/uniprot/Q63475", "type": "external" } ], "mass": 111863.0, "length": 1004, "protein_name": "Receptor-type tyrosine-protein phosphatase N2", "gene_name": "Ptprn2", "organism": "Rat", "refseq_name": "receptor-type tyrosine-protein phosphatase N2 precursor", "refseq_ac": [ { "id": "NP_113788", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113788", "type": "external" } ], "gene_names_uniprotkb": "Ptprn2", "gene_names_refseq": "PTPNE6; Ptprn2; R-PTP-N2", "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase N2; 3.1.3.-; 3.1.3.48; PTP NE-6; PTPNE6; Phogrin; R-PTP-N2", "protein_names_refseq": "PTP NE-6; phogrin; protein tyrosine phosphatase receptor-type N polypeptide 2; receptor-type tyrosine-protein phosphatase N2 precursor; receptor-type tyrosine-protein phosphatase N2", "tax_id": 10116, "disease": "prediabetes syndrome (Disease Ontology:DOID:11716); Parkinson's disease (Disease Ontology:DOID:14330); diabetes mellitus (Disease Ontology:DOID:9351); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:29714); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "11353772;14597614;15882444;20097759;22673903;25744490;34607132;8663434", "class_list": "", "function": "Knockdown of Ptprn-2 delays the onset of puberty in female rats., [RefSeq, PubMed]; Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Required to maintain normal levels of renin expression and renin release. May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (By similarity). Has phosphatidylinositol phosphatase activity; the PIPase activity is involved in its ability to regulate insulin secretion. Can dephosphorylate phosphatidylinositol 4,5-biphosphate, phosphatidylinositol 5-phosphate and phosphatidylinositol 3-phosphate (PubMed:20097759). Regulates PI(4,5)P2 level in the plasma membrane and localization of cofilin at the plasma membrane and thus is indirectly involved in regulation of actin dynamics related to cell migration and metastasis; upon hydrolysis of PI(4,5)P2 cofilin is released from the plasma membrane and acts in the cytoplasm in severing F-actin filaments (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.6.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.29", "type": "external" }, { "id": "3.4.16.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.2.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.20", "type": "external" } ], "go_molecular_function": "GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005788 endoplasmic reticulum lumen;GO:0030141 secretory granule;GO:0043195 terminal bouton;GO:0043235 receptor complex;GO:0045202 synapse", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0034260 negative regulation of GTPase activity;GO:0007269 neurotransmitter secretion;GO:0051046 regulation of secretion;GO:0035773 insulin secretion involved in cellular response to glucose stimulus", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q63475-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q794E4-1", "uniprot_id": [ { "id": "HNRPF_RAT", "url": "https://www.uniprot.org/uniprot/Q794E4", "type": "external" } ], "mass": 45730.0, "length": 415, "protein_name": "Heterogeneous nuclear ribonucleoprotein F", "gene_name": "Hnrnpf", "organism": "Rat", "refseq_name": "heterogeneous nuclear ribonucleoprotein F", "refseq_ac": [ { "id": "NP_001032362", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032362", "type": "external" } ], "gene_names_uniprotkb": "Hnrnpf; Hnrpf", "gene_names_refseq": "Hnrnpf; Hnrpf", "protein_names_uniprotkb": "Heterogeneous nuclear ribonucleoprotein F; hnRNP F", "protein_names_refseq": "heterogeneous nuclear ribonucleoprotein F; hnRNP F; ribonucleoprotein F", "tax_id": 10116, "disease": "renal glycosuria (Disease Ontology:DOID:9432)", "pathway": " (rno:64200); (R-RNO-6803529); (R-RNO-72163); (R-RNO-72203); (R-RNO-9770562)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "10471789;15659559;22673903;28424160;29393594", "class_list": "", "function": "Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state (By similarity)., [UniProtKB]; HnRNP F binds to rANG-IRE and modulates renal ANG gene expression, implicating that dysregulation of hnRNP F might affect renin-angiotensin system activation and, subsequently, kidney injury in diabetes, [RefSeq, PubMed]; HnRNP F protects kidneys against oxidative stress and nephropathy via stimulation of Sirtuin-1 expression and signaling in diabetes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003727 single-stranded RNA binding;GO:0017025 TBP-class protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0045202 synapse;GO:0071013 catalytic step 2 spliceosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0043484 regulation of RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q794E4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ESB5-1", "uniprot_id": [ { "id": "NECA1_RAT", "url": "https://www.uniprot.org/uniprot/Q9ESB5", "type": "external" } ], "mass": 40904.0, "length": 352, "protein_name": "N-terminal EF-hand calcium-binding protein 1", "gene_name": "Necab1", "organism": "Rat", "refseq_name": "N-terminal EF-hand calcium-binding protein 1", "refseq_ac": [ { "id": "NP_071638", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071638", "type": "external" } ], "gene_names_uniprotkb": "Necab1; Efcbp1; Stip", "gene_names_refseq": "Efcbp1; Necab1; Stip-1", "protein_names_uniprotkb": "N-terminal EF-hand calcium-binding protein 1; EF-hand calcium-binding protein 1; Neuronal calcium-binding protein 1; Stip-1; Synaptotagmin-interacting protein 1", "protein_names_refseq": "EF-hand calcium-binding protein 1; N-terminal EF-hand calcium-binding protein 1; neuronal Ca(2+)-binding protein 1; neuronal calcium-binding protein 1; synaptotagmin interacting protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:64169)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12044471;22673903", "class_list": "", "function": "Determines domain structure of the Necab 1 protein that expressed in the brain., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005929 cilium", "go_biological_process": "GO:0001835 blastocyst hatching;GO:0042984 regulation of amyloid precursor protein biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9ESB5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z301-1", "uniprot_id": [ { "id": "PER2_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z301", "type": "external" } ], "mass": 136028.0, "length": 1257, "protein_name": "Period circadian protein homolog 2", "gene_name": "Per2", "organism": "Rat", "refseq_name": "period circadian protein homolog 2", "refseq_ac": [ { "id": "NP_113866", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113866", "type": "external" } ], "gene_names_uniprotkb": "Per2", "gene_names_refseq": "Per2; rPER2", "protein_names_uniprotkb": "Period circadian protein homolog 2; Circadian clock protein PERIOD 2; rPER2", "protein_names_refseq": "circadian clock protein PERIOD 2; period circadian clock 2; period circadian protein homolog 2", "tax_id": 10116, "disease": "advanced sleep phase syndrome (Disease Ontology:DOID:0050628); fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); alcohol dependence (Disease Ontology:DOID:0050741); advanced sleep phase syndrome 1 (Disease Ontology:DOID:0110011); alcohol use disorder (Disease Ontology:DOID:1574); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (rno:63840); (R-RNO-9932298)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "11112428;11533252;12710990;14672706;15094047;18782782;22673903;31822134;32777474;32964673;35227001;37338051;9765215", "class_list": "", "function": "Alcohol suppresses cardiovascular diurnal variations in male normotensive rats: Role of reduced PER2 expression and CYP2E1 hyperactivity in the heart., [RefSeq, PubMed]; Depression-like behavior is associated with lower Per2 mRNA expression in the lateral habenula of rats., [RefSeq, PubMed]; Period 2-Induced Activation of Autophagy Improves Cardiac Remodeling After Myocardial Infarction., [RefSeq, PubMed]; Pers reverse angiotensin II -induced vascular smooth muscle cell proliferation by targeting cyclin E expression via inhibition of the MAPK signaling pathway., [RefSeq, PubMed]; This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders. [provided by RefSeq, Jan 2014]., [RefSeq]; Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndrome and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. PER1 and PER2 proteins transport CRY1 and CRY2 into the nucleus with appropriate circadian timing, but also contribute directly to repression of clock-controlled target genes through interaction with several classes of RNA-binding proteins, helicases and others transcriptional repressors. PER appears to regulate circadian control of transcription by at least three different modes. First, interacts directly with the CLOCK-BMAL1 at the tail end of the nascent transcript peak to recruit complexes containing the SIN3-HDAC that remodel chromatin to repress transcription. Second, brings H3K9 methyltransferases such as SUV39H1 and SUV39H2 to the E-box elements of the circadian target genes, like PER2 itself or PER1. The recruitment of each repressive modifier to the DNA seems to be very precisely temporally orchestrated by the large PER complex, the deacetylases acting before than the methyltransferases. Additionally, large PER complexes are also recruited to the target genes 3' termination site through interactions with RNA-binding proteins and helicases that may play a role in transcription termination to regulate transcription independently of CLOCK-BMAL1 interactions. Recruitment of large PER complexes to the elongating polymerase at PER and CRY termination sites inhibited SETX action, impeding RNA polymerase II release and thereby repressing transcriptional reinitiation. May propagate clock information to metabolic pathways via the interaction with nuclear receptors. Coactivator of PPARA and corepressor of NR1D1, binds rhythmically at the promoter of nuclear receptors target genes like BMAL1 or G6PC1. Directly and specifically represses PPARG proadipogenic activity by blocking PPARG recruitment to target promoters and thereby transcriptional activation. Required for fatty acid and lipid metabolism, is involved as well in the regulation of circulating insulin levels. Plays an important role in the maintenance of cardiovascular functions through the regulation of NO and vasodilatatory prostaglandins production in aortas. Controls circadian glutamate uptake in synaptic vesicles through the regulation of VGLUT1 expression. May also be involved in the regulation of inflammatory processes. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1 and ATF4. Negatively regulates the formation of the TIMELESS-CRY1 complex by competing with TIMELESS for binding to CRY1., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0036002 pre-mRNA binding;GO:0003713 transcription coactivator activity;GO:0042802 identical protein binding;GO:0042826 histone deacetylase binding;GO:0019900 kinase binding", "go_cellular_component": "GO:1990512 Cry-Per complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0070345 negative regulation of fat cell proliferation;GO:0060567 negative regulation of termination of DNA-templated transcription;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0002931 response to ischemia;GO:0003407 neural retina development", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9Z301-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68SB1-1", "uniprot_id": [ { "id": "STAU2_RAT", "url": "https://www.uniprot.org/uniprot/Q68SB1", "type": "external" } ], "mass": 62681.0, "length": 571, "protein_name": "Double-stranded RNA-binding protein Staufen homolog 2", "gene_name": "AABR07046707.1; Stau2", "organism": "Rat", "refseq_name": "double-stranded RNA-binding protein Staufen homolog 2 isoform SS", "refseq_ac": [ { "id": "NP_001007151", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007151", "type": "external" } ], "gene_names_uniprotkb": "AABR07046707.1; Stau2; AABR07046707.1; Stau2", "gene_names_refseq": "Stau2", "protein_names_uniprotkb": "Double-stranded RNA-binding protein Staufen homolog 2; r-staufen protein", "protein_names_refseq": "double-stranded RNA-binding protein Staufen homolog 2 isoform SS; double-stranded RNA-binding protein Staufen homolog 2; r-staufen protein; staufen, RNA binding protein, homolog 2", "tax_id": 10116, "disease": "microphthalmia (Disease Ontology:DOID:10629)", "pathway": " (rno:171500)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "11709157;12140260;12592035;15364930;15525674;15970630;16641100;24360961;28765142;28821679;29149906;34884825", "class_list": "", "function": "Data show that an isoform of Staufen2, Stau2(59), is exported from the nucleus by two distinct pathways, one of which is RNA-binding domain 3-mediated and the other of which is CRM1 (exportin 1)-dependent., [RefSeq, PubMed]; Here, we describe a new role for the ATP-dependent helicase UPF1 and its interaction with the RNA localization protein STAU2 in mediating mGluR-LTD through the regulation of mRNA translation complexes stalled at the level of elongation and/or termination. Erratum:[J Neurosci. 2017 Oct 18;37(42):10253. doi: 10.1523/JNEUROSCI.2761-17.2017. PMID: 31305598], [RefSeq, PubMed]; RBP Stau2 plays an important role in the regulation of specific aspects of hippocampal synaptic plasticity and learning and memory. Publication Status: Online-Only, [RefSeq, PubMed]; RGS4 RNA Secondary Structure Mediates Staufen2 RNP Assembly in Neurons. Publication Status: Online-Only, [RefSeq, PubMed]; RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Results identify the retained intron as a critical element in recruiting Stau2, which then allows for the localization of Calm3L mRNA to distal dendrites, [RefSeq, PubMed]; Stau2 stabilizes expression of Rgs4 mRNA via its 3' UTR in hippocampal neurons., [RefSeq, PubMed]; Staufen 1 and Staufen 2 are novel and ubiquitous stress granules components that are involved in repositioning of most polysomal mRNAs, but not of recently synthesized transcripts, during the stress response, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q68SB2;Q68SB3;Q68SB4;Q8R4C9;Q8R4D0", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0051019 mitogen-activated protein kinase binding;GO:0003725 double-stranded RNA binding;GO:0019894 kinesin binding;GO:0043022 ribosome binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0032956 regulation of actin cytoskeleton organization;GO:0034599 cellular response to oxidative stress;GO:0051965 positive regulation of synapse assembly;GO:0007281 germ cell development;GO:0051489 regulation of filopodium assembly", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q68SB1-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04764-1", "uniprot_id": [ { "id": "ENOA_RAT", "url": "https://www.uniprot.org/uniprot/P04764", "type": "external" } ], "mass": 47128.0, "length": 434, "protein_name": "Alpha-enolase", "gene_name": "Eno1-ps1; Eno1", "organism": "Rat", "refseq_name": "alpha-enolase isoform 1", "refseq_ac": [ { "id": "NP_001103378", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103378", "type": "external" } ], "gene_names_uniprotkb": "Eno1-ps1; Eno1; Eno-1; Eno1-ps1; Eno1", "gene_names_refseq": "Eno1; Nne", "protein_names_uniprotkb": "Alpha-enolase; 2-phospho-D-glycerate hydro-lyase; 4.2.1.11; Enolase 1; NNE; Non-neural enolase", "protein_names_refseq": "2-phospho-D-glycerate hydro-lyase; alpha-enolase isoform 1; alpha-enolase; enolase 1, (alpha); enolase 1, alpha non-neuron; non-neural enolase", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); neurodevelopmental disorder with or without autism or seizures (Disease Ontology:DOID:0061147); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); pseudohypoaldosteronism (Disease Ontology:DOID:4479)", "pathway": " (rno:24333)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10662718;15041191;18047804;18683930;19423663;21454685;2989793;30242159;31202897;32488097;32827683;34502162;38843836;7964722;8594891", "class_list": "", "function": "CircZNF609 aggravates neuropathic pain via miR-22-3p/ENO1 axis in CCI rat models., [RefSeq, PubMed]; Enolase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate in glycolysis and the reverse reaction in gluconeogenesis. Also involved in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production., [UniProtKB, UniProtKB]; Molecular characterization of a 1p36 chromosomal duplication and in utero interference define ENO1 as a candidate gene for polymicrogyria., [RefSeq, PubMed]; Regulates the metabolic reprogramming and malignant phenotype of pulmonary artery smooth muscle cells in pulmonary arterial hypertension Publication Status: Online-Only, [RefSeq, PubMed]; SIRT1 may regulate acetylation level of NSE and PKM through deacetylation and further regulate their catalytic activity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q66HI3;Q6AYV3;Q6P504", "ec_number_list": [ { "id": "4.2.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.11", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003723 RNA binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0009986 cell surface", "go_biological_process": "GO:0010756 positive regulation of plasminogen activation;GO:0045933 positive regulation of muscle contraction;GO:2001171 positive regulation of ATP biosynthetic process;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P04764-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63518-1", "uniprot_id": [ { "id": "MYPC1_RAT", "url": "https://www.uniprot.org/uniprot/Q63518", "type": "external" } ], "mass": 68737.0, "length": 621, "protein_name": "Myosin-binding protein C, slow-type", "gene_name": "Mybpc1", "organism": "Rat", "refseq_name": "myosin-binding protein C, slow-type", "refseq_ac": [ { "id": "NP_001094228", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094228", "type": "external" } ], "gene_names_uniprotkb": "Mybpc1", "gene_names_refseq": "Mybpc1", "protein_names_uniprotkb": "Myosin-binding protein C, slow-type; C-protein, skeletal muscle slow isoform; Slow MyBP-C", "protein_names_refseq": "muscle C-protein; myosin binding protein C, slow type; myosin-binding protein C, slow-type; slow MyBP-C", "tax_id": 10116, "disease": "distal arthrogryposis (Disease Ontology:DOID:0050646); lethal congenital contracture syndrome 4 (Disease Ontology:DOID:0060654); congenital myopathy (Disease Ontology:DOID:0081337); congenital myopathy 16 (Disease Ontology:DOID:0081348); distal arthrogryposis type 1B (Disease Ontology:DOID:0111598); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (rno:362867)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15098652;17900708;18817784;19403693;22673903;7673161", "class_list": "", "function": "A new ligand of obscurin at the M-band, MyBP-C slow variant-1 and suggest that their interaction contributes to the assembly of M-and A-bands, is identified., [RefSeq, PubMed]; Myosin-binding protein C (MyBP-C) has roles in cardiac muscle and contractility [review] Review article, [RefSeq, PubMed]; The distribution of MyBP-C in the A-bands of cardiac and skeletal muscles and compare this to the A-band structure in cardiac muscle of MyBP-C-deficient mice, was investigated., [RefSeq, PubMed]; These findings suggest that C-protein-induced EAM is formed by activation of C-protein-specific T cells along with antibodies against conformational epitopes in C-protein but that there are undetermined factors related to the disease progression., [RefSeq, PubMed]; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. Slow skeletal protein that binds to both myosin and actin. In vitro, binds to native thin filaments and modifies the activity of actin-activated myosin ATPase. May modulate muscle contraction or may play a more structural role., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0017022 myosin binding", "go_cellular_component": "GO:0032982 myosin filament;GO:0031430 M band", "go_biological_process": "GO:0006936 muscle contraction;GO:0007155 cell adhesion;GO:0048738 cardiac muscle tissue development;GO:0045214 sarcomere organization;GO:0060048 cardiac muscle contraction", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q63518-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TSE9-1", "uniprot_id": [ { "id": "HAX1_RAT", "url": "https://www.uniprot.org/uniprot/Q7TSE9", "type": "external" } ], "mass": 31448.0, "length": 278, "protein_name": "HCLS1-associated protein X-1", "gene_name": "Hax1", "organism": "Rat", "refseq_name": "HCLS1-associated protein X-1", "refseq_ac": [ { "id": "NP_853658", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_853658", "type": "external" } ], "gene_names_uniprotkb": "Hax1; Hs1bp1", "gene_names_refseq": "HAX-1; Hax1; Hs1bp1", "protein_names_uniprotkb": "HCLS1-associated protein X-1; HAX-1; HS1-associating protein X-1; HS1-binding protein 1; HSP1BP-1", "protein_names_refseq": "HCLS1-associated protein X-1; HS1 binding protein; HS1-associating protein X-1; HS1-binding protein 1; HSP1BP-1", "tax_id": 10116, "disease": "severe congenital neutropenia (Disease Ontology:DOID:0050590); severe congenital neutropenia 3 (Disease Ontology:DOID:0112133)", "pathway": " (rno:291202)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "15159385;16516414;19913549;23164465;24347163;27654581;27748880;30309497;32958249", "class_list": "", "function": "CPNE1-mediated neuronal differentiation can be inhibited by HAX1 expression in HiB5 cells., [RefSeq, PubMed]; HAX-1 binds bile salt export protein (BSEP), cortactin, MDR1, and MDR2. HAX-1 and cortactin regulate BSEP abundance in the apical membrane of cells., [RefSeq, PubMed]; Hax-1 is a family of anti- and proapoptotic regulators that may modulate cell survival and death through homo- or heterodimerization., [RefSeq, PubMed]; Hax1 is significantly downregulated in cardiac cells upon endoplasmic reticulum stress induction., [RefSeq, PubMed]; Our data indicated that HAX1 might play significant roles in pathological process of neuronal apoptosis and astrocyte proliferation during spinal cord injury, [RefSeq, PubMed]; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools., [UniProtKB, PubMed, UniProtKB, PubMed]; These results suggested that Hax1 may participate in regulating RGC apoptosis via interacting with caspase3 and HtrA2 following ONC., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5D1N3;Q5D1N4;Q7TSE7;Q7TSE8", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0019966 interleukin-1 binding;GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005758 mitochondrial intermembrane space;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0030854 positive regulation of granulocyte differentiation;GO:0043066 negative regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0071345 cellular response to cytokine stimulus", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q7TSE9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66HD0-1", "uniprot_id": [ { "id": "ENPL_RAT", "url": "https://www.uniprot.org/uniprot/Q66HD0", "type": "external" } ], "mass": 92771.0, "length": 804, "protein_name": "Endoplasmin", "gene_name": "Hsp90b1", "organism": "Rat", "refseq_name": "endoplasmin precursor", "refseq_ac": [ { "id": "NP_001012197", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012197", "type": "external" } ], "gene_names_uniprotkb": "Hsp90b1; Grp94; Hspc4; Tra1", "gene_names_refseq": "Grp94; Hsp90b1; Tra1", "protein_names_uniprotkb": "Endoplasmin; 3.6.4.-; 94 kDa glucose-regulated protein; GRP-94; Heat shock protein 90 kDa beta member 1", "protein_names_refseq": "94 kDa glucose-regulated protein; GRP-94; endoplasmin precursor; endoplasmin; heat shock protein 90 kDa beta member 1; heat shock protein 90, beta, member 1; heat shock protein 90kDa beta (Grp94), member 1; tumor rejection antigen gp96", "tax_id": 10116, "disease": "male infertility due to globozoospermia (Disease Ontology:DOID:0112312); lung adenocarcinoma (Disease Ontology:DOID:3910)", "pathway": " (rno:362862); (R-RNO-1679131); (R-RNO-3000480); (R-RNO-381426); (R-RNO-6785807); (R-RNO-8957275)", "pathway_count": 6, "publication_count": 11, "publication_id_list": "10.1039/D0MO00044B;19343716;22673903;24090084;29393594;30486828;30670477;34106099;34502162;38081093;38843836", "class_list": "", "function": "ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport. Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LRP6, a coreceptor of the canonical Wnt pathway (By similarity). When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Promotes folding and trafficking of TLR4 to the cell surface. May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; GRP94 in cerebrospinal fluid may contribute to a potential biomarker of depression: Based on proteomics., [RefSeq, PubMed]; We demonstrated that incubation of hepatocytes for 16 h with palmitic acid elevated cell death. Moreover, Western blot analyses demonstrated increased levels of the endoplasmic reticulum stress markers - glucose regulated protein 78 (GRP78), C/EBP homologous protein (CHOP), and glucose regulated protein 94 (GRP94). Publication Status: Online-Only, [RefSeq, PubMed]; We found that GRP94 coimmunoprecipitated with proinsulin and that inhibition of GRP94 function and/or expression reduced glucose-dependent insulin secretion, shortened proinsulin half-life, and lowered intracellular proinsulin and insulin levels., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 2, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "A6IFJ6", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.11.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9", "type": "external" }, { "id": "1.16.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.4", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.4.21.69", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.69", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.4.1.145", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.145", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.21.112", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.112", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0050750 low-density lipoprotein particle receptor binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0034663 endoplasmic reticulum chaperone complex;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005790 smooth endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0034123 positive regulation of toll-like receptor signaling pathway;GO:0043066 negative regulation of apoptotic process;GO:0072659 protein localization to plasma membrane;GO:0001666 response to hypoxia;GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q66HD0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIC0-1", "uniprot_id": [ { "id": "ECI2_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIC0", "type": "external" } ], "mass": 43021.0, "length": 391, "protein_name": "Enoyl-CoA delta isomerase 2", "gene_name": "Eci2; Eci3", "organism": "Rat", "refseq_name": "enoyl-CoA delta isomerase 2 precursor", "refseq_ac": [ { "id": "NP_001006967", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006967", "type": "external" } ], "gene_names_uniprotkb": "Eci2; Eci3; Eci2; Peci", "gene_names_refseq": "Eci2; Peci", "protein_names_uniprotkb": "Enoyl-CoA delta isomerase 2; 5.3.3.8; D3,D2-enoyl-CoA isomerase; Delta(3),delta(2)-enoyl-CoA isomerase; Dodecenoyl-CoA isomerase; Peroxisomal 3,2-trans-enoyl-CoA isomerase; pECI", "protein_names_refseq": "D3,D2-enoyl-CoA isomerase; delta(3),delta(2)-enoyl-CoA isomerase; dodecenoyl-CoA isomerase; enoyl-CoA delta isomerase 2 precursor; enoyl-CoA delta isomerase 2, mitochondrial; enoyl-Coenzyme A delta isomerase 2; peroxisomal 3,2-trans-enoyl-CoA isomerase; peroxisomal D3,D2-enoyl-CoA isomerase; peroxisomal delta3, delta2-enoyl-Coenzyme A isomerase", "tax_id": 10116, "disease": "", "pathway": " (rno:291075); (R-RNO-390247); (R-RNO-9033241)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "11781327;22673903;27213235", "class_list": "", "function": "Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "1.2.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "1.4.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "4.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.17", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "5.1.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "4.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.9", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" } ], "go_molecular_function": "GO:0000062 fatty-acyl-CoA binding;GO:0004165 delta(3)-delta(2)-enoyl-CoA isomerase activity;GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005782 peroxisomal matrix", "go_biological_process": "GO:0006635 fatty acid beta-oxidation;GO:0009062 fatty acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q5XIC0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33274-1", "uniprot_id": [ { "id": "CP4F1_RAT", "url": "https://www.uniprot.org/uniprot/P33274", "type": "external" } ], "mass": 59868.0, "length": 524, "protein_name": "Cytochrome P450 4F1", "gene_name": "Cyp4f1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cyp4f1; Cyp4f-1; Cyp4f2", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytochrome P450 4F1; 1.14.14.94; CYPIVF1; Cytochrome P450-A3; Leukotriene-B4 20-monooxygenase", "protein_names_refseq": "", "tax_id": 10116, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); hypertension (Disease Ontology:DOID:10763)", "pathway": " (R-RNO-211935); (R-RNO-211958); (R-RNO-211979); (R-RNO-2142691); (R-RNO-2142816)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "10486137;11980497;14634044;8424651", "class_list": "", "function": "A cytochrome P450 monooxygenase involved in the metabolism of arachidonic acid and its oxygenated derivatives (PubMed:10486137, PubMed:14634044). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Participates in the conversion of arachidonic acid to omega-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure (PubMed:14634044). May play a role in the oxidative inactivation of eicosanoids, including both pro-inflammatory and anti-inflammatory mediators such as leukotriene B4 (LTB4), lipoxin A4 (LXA4), and several HETEs (PubMed:10486137, PubMed:14634044)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" }, { "id": "4.2.1.152", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.152", "type": "external" }, { "id": "1.14.14.80", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.80", "type": "external" }, { "id": "1.14.14.94", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.94", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0050544 arachidonate binding;GO:0050051 leukotriene-B4 20-monooxygenase activity;GO:0052869 arachidonate omega-hydroxylase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006690 icosanoid metabolic process;GO:0097267 omega-hydroxylase P450 pathway;GO:0009636 response to toxic substance;GO:0019369 arachidonate metabolic process;GO:0036101 leukotriene B4 catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P33274-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P34926-1", "uniprot_id": [ { "id": "MAP1A_RAT", "url": "https://www.uniprot.org/uniprot/P34926", "type": "external" } ], "mass": 299531.0, "length": 2774, "protein_name": "Microtubule-associated protein 1A", "gene_name": "Map1a", "organism": "Rat", "refseq_name": "microtubule-associated protein 1A", "refseq_ac": [ { "id": "NP_112257", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112257", "type": "external" } ], "gene_names_uniprotkb": "Map1a; Mtap1a", "gene_names_refseq": "Map1a; Mtap1a", "protein_names_uniprotkb": "Microtubule-associated protein 1A; MAP-1A", "protein_names_refseq": "MAP-1A; microtubule-associated protein 1A", "tax_id": 10116, "disease": "Down syndrome (Disease Ontology:DOID:14250); hypothyroidism (Disease Ontology:DOID:1459)", "pathway": " (rno:25152)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "1379599;15961172;18683930;22673903;36414406;37705167;38843836;8647865;9786987", "class_list": "", "function": "Intracellular Accumulation of alpha-Synuclein Aggregates Promotes S-Nitrosylation of MAP1A Leading to Decreased NMDAR-Evoked Calcium Influx and Loss of Mature Synaptic Spines., [RefSeq, PubMed]; Phosphorylation of MAP 1A regulates hyperphosphorylation of Tau in Alzheimer's disease model., [RefSeq, PubMed]; Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 81, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0008017 microtubule binding;GO:0005518 collagen binding;GO:0008093 cytoskeletal anchor activity;GO:0015631 tubulin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule;GO:0014069 postsynaptic density", "go_biological_process": "GO:0050882 voluntary musculoskeletal movement;GO:0099641 anterograde axonal protein transport;GO:0007409 axonogenesis;GO:0007613 memory;GO:0008306 associative learning", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P34926-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97879-1", "uniprot_id": [ { "id": "GRIP1_RAT", "url": "https://www.uniprot.org/uniprot/P97879", "type": "external" } ], "mass": 120298.0, "length": 1112, "protein_name": "Glutamate receptor-interacting protein 1", "gene_name": "Grip1", "organism": "Rat", "refseq_name": "glutamate receptor-interacting protein 1", "refseq_ac": [ { "id": "NP_114458", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114458", "type": "external" } ], "gene_names_uniprotkb": "Grip1", "gene_names_refseq": "Grip1", "protein_names_uniprotkb": "Glutamate receptor-interacting protein 1; AMPA receptor-interacting protein GRIP1; GRIP-1", "protein_names_refseq": "AMPA receptor-interacting protein GRIP1; GRIP-1; glutamate receptor-interacting protein 1", "tax_id": 10116, "disease": "recessive dystrophic epidermolysis bullosa (Disease Ontology:DOID:0060642); Fraser syndrome (Disease Ontology:DOID:0090001); Fraser syndrome 3 (Disease Ontology:DOID:0111406); clubfoot (Disease Ontology:DOID:11836)", "pathway": " (rno:84016); (R-RNO-416993)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10436050;10896157;11931740;12115684;12196542;12458226;14730302;15226318;16037816;21496646;22673903;26109571;26216979;28821652;9069286", "class_list": "", "function": "Data show that glutamate receptor-interacting protein-1 (GRIP1) is recruited to synapses under conditions of hypoactivity., [RefSeq, PubMed]; May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons (PubMed:9069286). Through complex formation with NSG1, GRIA2 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (PubMed:16037816)., [UniProtKB, PubMed, PubMed]; Our findings indicate that calpain-GRIP signaling is essential for the restabilization process that is associated with drug cue memory and the inhibition of calpain activity may be a novel strategy for the prevention of drug relapse., [RefSeq, PubMed]; Subcellular redistribution of GRIP1 and a change in the binding of GRIP1 to GluA2 during synaptic scaling, was observed., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0051020 GTPase binding;GO:0030165 PDZ domain binding;GO:0035255 ionotropic glutamate receptor binding;GO:0140318 protein transporter activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005874 microtubule;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:1990416 cellular response to brain-derived neurotrophic factor stimulus;GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane;GO:0007399 nervous system development;GO:0021987 cerebral cortex development;GO:0060292 long-term synaptic depression", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P97879-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66H38-1", "uniprot_id": [ { "id": "GAR3_RAT", "url": "https://www.uniprot.org/uniprot/Q66H38", "type": "external" } ], "mass": 68071.0, "length": 647, "protein_name": "Golgi-associated RAB2B interactor protein 3", "gene_name": "Garin3", "organism": "Rat", "refseq_name": "Golgi-associated RAB2B interactor protein 3", "refseq_ac": [ { "id": "NP_001020202", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020202", "type": "external" } ], "gene_names_uniprotkb": "Garin3; Fam71b", "gene_names_refseq": "Fam71b; Garin3", "protein_names_uniprotkb": "Golgi-associated RAB2B interactor protein 3; Protein FAM71B", "protein_names_refseq": "Golgi associated RAB2B interactor protein 3; Golgi-associated RAB2B interactor protein 3; Golgi-associated Rab2B interactor-like 3; family with sequence similarity 71, member B; golgi associated RAB2B interactor family member 3; protein FAM71B", "tax_id": 10116, "disease": "", "pathway": " (rno:497888)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "May be involved in RNA biogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0061827 sperm head;GO:0005794 Golgi apparatus;GO:0015030 Cajal body", "go_biological_process": "GO:0007339 binding of sperm to zona pellucida;GO:0030317 flagellated sperm motility;GO:0000902 cell morphogenesis;GO:0007286 spermatid development;GO:0007338 single fertilization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q66H38-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0BN94-1", "uniprot_id": [ { "id": "TIMCC_RAT", "url": "https://www.uniprot.org/uniprot/B0BN94", "type": "external" } ], "mass": 15625.0, "length": 138, "protein_name": "TIM double twin CX3C motif protein", "gene_name": "Fam136a; Timcc", "organism": "Rat", "refseq_name": "protein FAM136A", "refseq_ac": [ { "id": "NP_001100075", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100075", "type": "external" } ], "gene_names_uniprotkb": "Fam136a; Timcc; Fam136a", "gene_names_refseq": "Fam136a; RGD1304825; Timcc", "protein_names_uniprotkb": "TIM double twin CX3C motif protein", "protein_names_refseq": "family with sequence similarity 136, member A; protein FAM136A", "tax_id": 10116, "disease": "", "pathway": " (rno:297415)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16641100;25305078", "class_list": "", "function": "Plays a role in proteostasis of the mitochondrion intermembrane space and counteracts aggregation of certain proteins. Required for mitochondrial oxidative phosphorylation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B0BN94-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0BNA5-1", "uniprot_id": [ { "id": "COTL1_RAT", "url": "https://www.uniprot.org/uniprot/B0BNA5", "type": "external" } ], "mass": 15932.0, "length": 142, "protein_name": "Coactosin-like protein", "gene_name": "Cotl1", "organism": "Rat", "refseq_name": "coactosin-like protein", "refseq_ac": [ { "id": "NP_001101922", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101922", "type": "external" } ], "gene_names_uniprotkb": "Cotl1; Clp", "gene_names_refseq": "Clp; Cotl1", "protein_names_uniprotkb": "Coactosin-like protein", "protein_names_refseq": "coactosin-like 1; coactosin-like protein", "tax_id": 10116, "disease": "", "pathway": " (rno:361422); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22673903;28925397", "class_list": "", "function": "Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Study uncovers a novel tumor-suppressor role for CLP/Cotl1 and identify the downstream effectors interleukin 24 (IL-24)/PERP and IL-24/MAPK/ERK/TGF-beta., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0019899 enzyme binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0030864 cortical actin cytoskeleton;GO:0030427 site of polarized growth;GO:0005856 cytoskeleton", "go_biological_process": "GO:0050832 defense response to fungus;GO:0030833 regulation of actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B0BNA5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ESV6-1", "uniprot_id": [ { "id": "G3PT_RAT", "url": "https://www.uniprot.org/uniprot/Q9ESV6", "type": "external" } ], "mass": 46708.0, "length": 432, "protein_name": "Glyceraldehyde-3-phosphate dehydrogenase, testis-specific", "gene_name": "Gapdhs", "organism": "Rat", "refseq_name": "glyceraldehyde-3-phosphate dehydrogenase, testis-specific", "refseq_ac": [ { "id": "NP_076454", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076454", "type": "external" } ], "gene_names_uniprotkb": "Gapdhs; Gapd-s; Gapds", "gene_names_refseq": "Gapdhs; Gapds; gapdh-2", "protein_names_uniprotkb": "Glyceraldehyde-3-phosphate dehydrogenase, testis-specific; 1.2.1.12; GAPDH-2; Spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase 2; Spermatogenic glyceraldehyde-3-phosphate dehydrogenase", "protein_names_refseq": "glyceraldehyde-3-phosphate dehydrogenase type 2; glyceraldehyde-3-phosphate dehydrogenase, testis-specific; spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase 2; spermatogenic glyceraldehyde-3-phosphate dehydrogenase", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (rno:66020); (R-RNO-70171); (R-RNO-70263)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "16700075;19423663;19542219;22673903;23306140", "class_list": "", "function": "Catalyzes the conversion of D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate in glycolysis and the reverse reaction in gluconeogenesis (By similarity). May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; GAPDS protein was expressed in both Sertoli cells and elongated sperms. The expression of GAPDS gradually increased with age in the epididymis., [RefSeq, PubMed]; Results describe the expression of the spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase (GAPDS) in rat testis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.2.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.12", "type": "external" }, { "id": "2.6.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.99.-", "type": "external" } ], "go_molecular_function": "GO:0051287 NAD binding;GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity;GO:0050661 NADP binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005929 cilium;GO:0031514 motile cilium;GO:0001669 acrosomal vesicle;GO:0035686 sperm fibrous sheath", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0007286 spermatid development;GO:0006006 glucose metabolic process;GO:0006096 glycolytic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9ESV6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54757-1", "uniprot_id": [ { "id": "EPHA5_RAT", "url": "https://www.uniprot.org/uniprot/P54757", "type": "external" } ], "mass": 111007.0, "length": 1005, "protein_name": "Ephrin type-A receptor 5", "gene_name": "Epha5", "organism": "Rat", "refseq_name": "ephrin type-A receptor 5 isoform 2", "refseq_ac": [ { "id": "NP_077343", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077343", "type": "external" } ], "gene_names_uniprotkb": "Epha5; Ehk-1; Ekh1; Rek7", "gene_names_refseq": "EHK-1; Els1.; Els1; Epha5", "protein_names_uniprotkb": "Ephrin type-A receptor 5; 2.7.10.1; EHK-1; EPH homology kinase 1", "protein_names_refseq": "EPH homology kinase 1; eck-like sequence 1; ephrin type-A receptor 5 isoform 2; ephrin type-A receptor 5; tyrosine-protein kinase receptor EHK-1", "tax_id": 10116, "disease": "", "pathway": " (rno:79208); (R-RNO-2682334); (R-RNO-3928663); (R-RNO-3928665)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "20824214;24222347;26109526;29237529;29330744;38843836;7504232;7748564;7898646;9698392", "class_list": "", "function": "C-fos overexpression could upregulate EphA5 expression in hippocampal neurons of rats with congenital hypothyroidism., [RefSeq, PubMed]; Changes in ephrinA5/EphA5 interactions and synaptic plasticity within the ventromedial hypothalamus may contribute to the impairment in glucagon secretion and counterregulatory responses caused by recurrent hypoglycemia., [RefSeq, PubMed]; Downregulation of ephrinA5 and EphA5 in the CA3 region of the hippocampus may participate in the mechanism of mossy fiber sprouting and is closely associated with the development and progression of epilepsy., [RefSeq, PubMed]; EphA5 promoter methylation in the hippocampus of rats with congenital hypothyroidism is associated with the levels of EphA5 expression., [RefSeq, PubMed]; Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 6, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0019838 growth factor binding;GO:0005005 transmembrane-ephrin receptor activity;GO:0005003 ephrin receptor activity;GO:0005004 GPI-linked ephrin receptor activity", "go_cellular_component": "GO:0005791 rough endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0007162 negative regulation of cell adhesion;GO:0048013 ephrin receptor signaling pathway;GO:0021766 hippocampus development;GO:1904322 cellular response to forskolin;GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P54757-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0100000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PPK9-1", "uniprot_id": [ { "id": "EIPR1_RAT", "url": "https://www.uniprot.org/uniprot/Q5PPK9", "type": "external" } ], "mass": 43157.0, "length": 386, "protein_name": "EARP and GARP complex-interacting protein 1", "gene_name": "Eipr1", "organism": "Rat", "refseq_name": "EARP and GARP complex-interacting protein 1", "refseq_ac": [ { "id": "NP_001012192", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012192", "type": "external" } ], "gene_names_uniprotkb": "Eipr1; Tssc1", "gene_names_refseq": "Eipr1; Tssc1", "protein_names_uniprotkb": "EARP and GARP complex-interacting protein 1; Endosome-associated recycling protein-interacting protein; Golgi-associated retrograde protein-interacting protein; Tumor-suppressing STF cDNA 1 protein; Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein", "protein_names_refseq": "EARP and GARP complex-interacting protein 1; EARP-interacting protein; Golgi-associated retrograde protein-interacting protein; endosome-associated recycling protein-interacting protein; protein TSSC1; tumor suppressing subtransferable candidate 1; tumor-suppressing STF cDNA 1 protein; tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein", "tax_id": 10116, "disease": "", "pathway": " (rno:362721)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "27191843;27440922;3172165", "class_list": "", "function": "Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network (By similarity). Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein (By similarity). Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome-associated recycling protein (EARP) complex (By similarity). Controls proper insulin distribution and secretion, and retention of cargo in mature dense core vesicles (PubMed:3172165). Required for the stability of the endosome-associated retrograde protein (EARP) complex subunits and for proper localization and association of EARP with membranes (PubMed:3172165)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000938 GARP complex;GO:1990745 EARP complex;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0050796 regulation of insulin secretion;GO:0016567 protein ubiquitination;GO:2001137 positive regulation of endocytic recycling;GO:0032456 endocytic recycling;GO:1905281 positive regulation of retrograde transport, endosome to Golgi", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5PPK9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P25093-1", "uniprot_id": [ { "id": "FAAA_RAT", "url": "https://www.uniprot.org/uniprot/P25093", "type": "external" } ], "mass": 45976.0, "length": 419, "protein_name": "Fumarylacetoacetase", "gene_name": "Fah", "organism": "Rat", "refseq_name": "fumarylacetoacetase", "refseq_ac": [ { "id": "NP_058877", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058877", "type": "external" } ], "gene_names_uniprotkb": "Fah", "gene_names_refseq": "Fah", "protein_names_uniprotkb": "Fumarylacetoacetase; 3.7.1.2; Beta-diketonase; FAA; Fumarylacetoacetate hydrolase", "protein_names_refseq": "FAA; beta-diketonase; fumarylacetoacetase", "tax_id": 10116, "disease": "tyrosinemia type I (Disease Ontology:DOID:0050726); hypertension (Disease Ontology:DOID:10763); liver cirrhosis (Disease Ontology:DOID:5082)", "pathway": " (rno:29383); (R-RNO-8963684)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "1916290;22673903;25677510;27510266", "class_list": "", "function": "Urinary excretion of fumarylacetoacetase is a potential biomarker candidate of predisposition to kidney injury induced by sub-toxic administration of cisplatin., [RefSeq, PubMed]; Using CRISPR/Cas9 technique, Fah(-/-) rats were generated. They faithfully represented major phenotypic and biochemical manifestations of human ereditary tyrosinemia type I (HT1), including hypertyrosinemia, liver failure, and renal tubular damage. More importantly, they developed remarkable liver fibrosis and cirrhosis which can be prevented with wild-type hepatocytes transplantation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.7.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.7.1.2", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004334 fumarylacetoacetase activity", "go_cellular_component": "", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006559 L-phenylalanine catabolic process;GO:0006572 L-tyrosine catabolic process;GO:0006527 L-arginine catabolic process;GO:1902000 homogentisate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P25093-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P80020-1", "uniprot_id": [ { "id": "FABP6_RAT", "url": "https://www.uniprot.org/uniprot/P80020", "type": "external" } ], "mass": 14544.0, "length": 128, "protein_name": "Gastrotropin", "gene_name": "Fabp6", "organism": "Rat", "refseq_name": "gastrotropin", "refseq_ac": [ { "id": "NP_058794", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058794", "type": "external" } ], "gene_names_uniprotkb": "Fabp6; Ilbp; Illbp", "gene_names_refseq": "Fabp6; IBABP", "protein_names_uniprotkb": "Gastrotropin; 14 kDa bile acid-binding protein; Fatty acid-binding protein 6; GT; I-15P; I-BABP; ILBP; Ileal lipid-binding protein; Intestinal 15 kDa protein", "protein_names_refseq": "14 kDa bile acid-binding protein; Fatty acid binding protein 6 (bile acid-binding protein); GT; I-15P; I-BABP; ILBP; fatty acid binding protein 6, ileal; gastrotropin; ileal lipid-binding protein; intestinal 15 kDa protein; strain SHR/OlaIpcv fatty acid binding protein 6 (Fabp6) pseudogene", "tax_id": 10116, "disease": "congenital adrenal hyperplasia (Disease Ontology:DOID:0050811); adrenal cortical adenoma (Disease Ontology:DOID:0050891); stroke (Disease Ontology:DOID:0051061); corticosterone methyloxidase deficiency 1 (Disease Ontology:DOID:0080626); dilated cardiomyopathy 1H (Disease Ontology:DOID:0110429); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); primary hyperaldosteronism (Disease Ontology:DOID:446); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:25440); (R-RNO-159418); (R-RNO-163560)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "12974472;2029905;2059206;8197128;8422242", "class_list": "", "function": "Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes (By similarity). Stimulates gastric acid and pepsinogen secretion (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; The intronless Fabp6 segment, which might be a pseudogene of Fabp6, was localized on rat chromosome 15., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005504 fatty acid binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0015908 fatty acid transport;GO:0008202 steroid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P80020-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q924C3-1", "uniprot_id": [ { "id": "ENPP1_RAT", "url": "https://www.uniprot.org/uniprot/Q924C3", "type": "external" } ], "mass": 102942.0, "length": 906, "protein_name": "Ectonucleotide pyrophosphatase/phosphodiesterase family member 1", "gene_name": "Enpp1", "organism": "Rat", "refseq_name": "ectonucleotide pyrophosphatase/phosphodiesterase family member 1", "refseq_ac": [ { "id": "NP_445987", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445987", "type": "external" } ], "gene_names_uniprotkb": "Enpp1; Npps; Pc1; Pdnp1", "gene_names_refseq": "Enpp1; Npps; Pc1", "protein_names_uniprotkb": "Ectonucleotide pyrophosphatase/phosphodiesterase family member 1; 3.1.4.1; 3.6.1.9; Alkaline phosphodiesterase I; E-NPP 1; NPPase; Nucleotide diphosphatase; Nucleotide pyrophosphatase; Phosphodiesterase I/nucleotide pyrophosphatase 1; Plasma-cell membrane glycoprotein PC-1", "protein_names_refseq": "E-NPP 1; NPPase; alkaline phosphodiesterase I; ectonucleotide pyrophosphatase/phosphodiesterase family member 1; nucleotide diphosphatase; phosphodiesterase I/nucleotide pyrophosphatase 1; plasma-cell membrane glycoprotein PC-1", "tax_id": 10116, "disease": "arterial calcification of infancy (Disease Ontology:DOID:0050644); stroke (Disease Ontology:DOID:0051061); ossification of the posterior longitudinal ligament of spine (Disease Ontology:DOID:0060887); aortic valve disease 1 (Disease Ontology:DOID:0080333); otitis media (Disease Ontology:DOID:10754); spondyloarthropathy (Disease Ontology:DOID:1123); tympanosclerosis (Disease Ontology:DOID:1214); cardiovascular system disease (Disease Ontology:DOID:1287); pseudoxanthoma elasticum (Disease Ontology:DOID:2738); glioblastoma (Disease Ontology:DOID:3068); end stage renal disease (Disease Ontology:DOID:783); osteoarthritis (Disease Ontology:DOID:8398); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:85496); (R-RNO-196843)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "12121276;16641100;21454685;22673903;37814911", "class_list": "", "function": "ENPP1 downregulation and FGF23 upregulation in growth-related calcification of the tibial tuberosity in rats., [RefSeq, PubMed]; Nucleotide pyrophosphatase that generates diphosphate (PPi) and functions in bone mineralization and soft tissue calcification by regulating pyrophosphate levels. PPi inhibits bone mineralization and soft tissue calcification by binding to nascent hydroxyapatite crystals, thereby preventing further growth of these crystals. Preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP and UTP to their corresponding monophosphates with release of pyrophosphate, as well as diadenosine polyphosphates, and also 3',5'-cAMP to AMP. May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling. Inhibits ectopic joint calcification and maintains articular chondrocytes by repressing hedgehog signaling; it is however unclear whether hedgehog inhibition is direct or indirect (By similarity). Appears to modulate insulin sensitivity. Also involved in melanogenesis (By similarity). Also able to hydrolyze 2',3'-cGAMP (cyclic GMP-AMP), a second messenger that activates TMEM173/STING and triggers type-I interferon production (By similarity). 2',3'-cGAMP degradation takes place in the lumen or extracellular space, and not in the cytosol where it is produced; the role of 2',3'-cGAMP hydrolysis is therefore unclear. Not able to hydrolyze the 2',3'-cGAMP linkage isomer 3'-3'-cGAMP (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q91XQ3;Q920C8", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.53", "type": "external" }, { "id": "3.6.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9", "type": "external" }, { "id": "3.6.1.68", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.68", "type": "external" }, { "id": "3.6.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.76", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1", "type": "external" }, { "id": "3.1.4.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.17", "type": "external" }, { "id": "3.6.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.59", "type": "external" }, { "id": "3.6.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.52", "type": "external" }, { "id": "3.6.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.62", "type": "external" }, { "id": "3.6.1.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.10", "type": "external" }, { "id": "3.6.1.61", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.61", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.25", "type": "external" }, { "id": "3.6.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.14", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" } ], "go_molecular_function": "GO:0030247 polysaccharide binding;GO:0016462 pyrophosphatase activity;GO:0005044 scavenger receptor activity;GO:0005158 insulin receptor binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0046627 negative regulation of insulin receptor signaling pathway;GO:1904383 response to sodium phosphate;GO:0071344 diphosphate metabolic process;GO:0050954 sensory perception of mechanical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q924C3-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54924-1", "uniprot_id": [ { "id": "EXOC8_RAT", "url": "https://www.uniprot.org/uniprot/O54924", "type": "external" } ], "mass": 81043.0, "length": 716, "protein_name": "Exocyst complex component 8", "gene_name": "Exoc8", "organism": "Rat", "refseq_name": "exocyst complex component 8", "refseq_ac": [ { "id": "NP_620612", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620612", "type": "external" } ], "gene_names_uniprotkb": "Exoc8; Exo84", "gene_names_refseq": "Exo84; Exoc8", "protein_names_uniprotkb": "Exocyst complex component 8; Exocyst complex 84 kDa subunit", "protein_names_refseq": "exocyst complex 84 kDa subunit; exocyst complex component 8", "tax_id": 10116, "disease": "", "pathway": " (rno:245709); (R-RNO-264876); (R-RNO-5620916)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "12954101;15920473;21658605;22673903;29393594;9405631", "class_list": "", "function": "Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0030426 growth cone;GO:0031252 cell leading edge;GO:0048471 perinuclear region of cytoplasm;GO:0005770 late endosome;GO:0000145 exocyst", "go_biological_process": "GO:0015031 protein transport;GO:0022617 extracellular matrix disassembly;GO:0007032 endosome organization;GO:0008104 intracellular protein localization;GO:0006887 exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O54924-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06761-1", "uniprot_id": [ { "id": "BIP_RAT", "url": "https://www.uniprot.org/uniprot/P06761", "type": "external" } ], "mass": 72347.0, "length": 654, "protein_name": "Endoplasmic reticulum chaperone BiP", "gene_name": "Hspa5", "organism": "Rat", "refseq_name": "endoplasmic reticulum chaperone BiP precursor", "refseq_ac": [ { "id": "NP_037215", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037215", "type": "external" } ], "gene_names_uniprotkb": "Hspa5; Grp78", "gene_names_refseq": "BIP; GRP 78; GRP78; Hspa5", "protein_names_uniprotkb": "Endoplasmic reticulum chaperone BiP; 3.6.4.10; 78 kDa glucose-regulated protein; BiP; Binding-immunoglobulin protein; GRP-78; HSP70 family protein 5; Heat shock protein 70 family protein 5; Heat shock protein family A member 5; Immunoglobulin heavy chain-binding protein; Steroidogenesis-activator polypeptide", "protein_names_refseq": "78 kDa glucose-regulated protein; GRP-78; HSP70 family protein 5; binding-immunoglobulin protein; endoplasmic reticulum chaperone BiP precursor; endoplasmic reticulum chaperone BiP; heat shock 70 kDa protein 5; heat shock 70kD protein 5; heat shock 70kDa protein 5 (glucose-regulated protein); heat shock protein 5; heat shock protein 70 family protein 5; heat shock protein family A member 5; immunoglobulin heavy chain-binding protein; steroidogenesis-activator polypeptide", "tax_id": 10116, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); cardiomyopathy (Disease Ontology:DOID:0050700); congenital diarrhea 7 with exudative enteropathy (Disease Ontology:DOID:0060778); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); dopamine beta-hydroxylase deficiency (Disease Ontology:DOID:0090145); nephrotic syndrome (Disease Ontology:DOID:1184); post-traumatic stress disorder (Disease Ontology:DOID:2055); transient cerebral ischemia (Disease Ontology:DOID:224); high grade glioma (Disease Ontology:DOID:3070); ureteral obstruction (Disease Ontology:DOID:5199); rheumatoid arthritis (Disease Ontology:DOID:7148); chronic kidney disease (Disease Ontology:DOID:784); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25617); (R-RNO-3371453); (R-RNO-983170)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "12475965;12514190;22673903;3087629;34502162;3468506;3563495;37499993;38050647;38105649;38843836;39002476", "class_list": "", "function": "CYP2E1 triggered GRP78/ATF6/CHOP signaling axis inhibit apoptosis and promotes progression of hepatocellular carcinoma., [RefSeq, PubMed]; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the EIF2AK3/PERK and ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1. Also binds and inactivates EIF2AK3/PERK in unstressed cells. Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1 and EIF2AK3/PERK, allowing their homodimerization and subsequent activation (By similarity). Plays an auxiliary role in post-translational transport of small presecretory proteins across endoplasmic reticulum (ER). May function as an allosteric modulator for SEC61 channel-forming translocon complex, likely cooperating with SEC62 to enable the productive insertion of these precursors into SEC61 channel. Appears to specifically regulate translocation of precursors having inhibitory residues in their mature region that weaken channel gating. May also play a role in apoptosis and cell proliferation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Endoplasmic reticulum stress caused by traumatic injury promotes cardiomyocyte apoptosis through acetylation modification of GRP78., [RefSeq, PubMed]; GRP78 improves the therapeutic effect of mesenchymal stem cells on hemorrhagic shock-induced liver injury: Involvement of the NF-small ka, CyrillicB and HO-1/Nrf-2 pathways., [RefSeq, PubMed]; GRP78/IRE1 and cGAS/STING pathway crosstalk through CHOP facilitates iodoacetic acid-mediated testosterone decline., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 14, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0019904 protein domain specific binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0034663 endoplasmic reticulum chaperone complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:1903894 regulation of IRE1-mediated unfolded protein response;GO:0010976 positive regulation of neuron projection development;GO:0030335 positive regulation of cell migration;GO:0036498 IRE1-mediated unfolded protein response;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P06761-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15429-1", "uniprot_id": [ { "id": "ENOB_RAT", "url": "https://www.uniprot.org/uniprot/P15429", "type": "external" } ], "mass": 47014.0, "length": 434, "protein_name": "Beta-enolase", "gene_name": "Eno3", "organism": "Rat", "refseq_name": "beta-enolase", "refseq_ac": [ { "id": "NP_037081", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037081", "type": "external" } ], "gene_names_uniprotkb": "Eno3; Eno-3", "gene_names_refseq": "BBE; Eno3; MSE", "protein_names_uniprotkb": "Beta-enolase; 2-phospho-D-glycerate hydro-lyase; 4.2.1.11; Enolase 3; MSE; Muscle-specific enolase; Skeletal muscle enolase", "protein_names_refseq": "2-phospho-D-glycerate hydro-lyase; Muscle specific enolase (beta beta enolose) (two splicing products); beta-enolase; enolase 3, beta, muscle; muscle-specific enolase; skeletal muscle enolase", "tax_id": 10116, "disease": "syndromic X-linked intellectual disability Cabezas type (Disease Ontology:DOID:0060822); intellectual disability (Disease Ontology:DOID:1059); aortic valve stenosis (Disease Ontology:DOID:1712)", "pathway": " (rno:25438); (R-RNO-70171); (R-RNO-70263)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10662718;14985449;19141407;22673903;2269373;2914621;8594891", "class_list": "", "function": "Enolase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate in glycolysis and the reverse reaction in gluconeogenesis. Appears to have a function in striated muscle development and regeneration., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The cellular localization of the muscle-specific isoform of the enolase in normal rat cardiomyocytes (H9c2, an embryonic rat heart-derived cell line) and a rat sarcoma (R1) cell line is reported here., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5XIV3", "ec_number_list": [ { "id": "4.2.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.11", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0004634 phosphopyruvate hydratase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0000015 phosphopyruvate hydratase complex", "go_biological_process": "GO:0043403 skeletal muscle tissue regeneration;GO:0006096 glycolytic process;GO:0061621 canonical glycolysis;GO:0009410 response to xenobiotic stimulus", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P15429-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22388-1", "uniprot_id": [ { "id": "EDN1_RAT", "url": "https://www.uniprot.org/uniprot/P22388", "type": "external" } ], "mass": 23135.0, "length": 202, "protein_name": "Endothelin-1", "gene_name": "Edn1", "organism": "Rat", "refseq_name": "endothelin-1 preproprotein", "refseq_ac": [ { "id": "NP_036680", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036680", "type": "external" } ], "gene_names_uniprotkb": "Edn1", "gene_names_refseq": "Edn1; Et1", "protein_names_uniprotkb": "Endothelin-1; ET-1; PPET1; Preproendothelin-1", "protein_names_refseq": "ET-1; PPET1; endothelin-1 preproprotein; preproendothelin-1", "tax_id": 10116, "disease": "aspiration pneumonia (Disease Ontology:DOID:0050152); metabolic acidosis (Disease Ontology:DOID:0050758); obstructive sleep apnea (Disease Ontology:DOID:0050848); atrial fibrillation (Disease Ontology:DOID:0060224); childhood-onset asthma (Disease Ontology:DOID:0080815); aortic atherosclerosis (Disease Ontology:DOID:10230); retinitis pigmentosa (Disease Ontology:DOID:10584); primary open angle glaucoma (Disease Ontology:DOID:1070); kidney failure (Disease Ontology:DOID:1074); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); intracranial aneurysm (Disease Ontology:DOID:10941); nephritis (Disease Ontology:DOID:10952); adult respiratory distress syndrome (Disease Ontology:DOID:11394); heart disease (Disease Ontology:DOID:114); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930); Behcet's disease (Disease Ontology:DOID:13241); low tension glaucoma (Disease Ontology:DOID:13544); angle-closure glaucoma (Disease Ontology:DOID:13550); exfoliation syndrome (Disease Ontology:DOID:13641); cystic fibrosis (Disease Ontology:DOID:1485); neovascular glaucoma (Disease Ontology:DOID:1687); impotence (Disease Ontology:DOID:1875); optic nerve disease (Disease Ontology:DOID:1891); hypogonadism (Disease Ontology:DOID:1924); brain ischemia (Disease Ontology:DOID:2316); multiple sclerosis (Disease Ontology:DOID:2377); renal artery disease (Disease Ontology:DOID:2388); nephrosis (Disease Ontology:DOID:2527); bronchiolitis obliterans (Disease Ontology:DOID:2799); asthma (Disease Ontology:DOID:2841); membranoproliferative glomerulonephritis (Disease Ontology:DOID:2920); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); coronary artery disease (Disease Ontology:DOID:3393); pulmonary fibrosis (Disease Ontology:DOID:3770); ovarian carcinoma (Disease Ontology:DOID:4001); systemic scleroderma (Disease Ontology:DOID:418); coronary stenosis (Disease Ontology:DOID:4248); uremia (Disease Ontology:DOID:4676); liver cirrhosis (Disease Ontology:DOID:5082); ureteral obstruction (Disease Ontology:DOID:5199); retinal detachment (Disease Ontology:DOID:5327); pneumonia (Disease Ontology:DOID:552); myocardial infarction (Disease Ontology:DOID:5844); anterolateral myocardial infarction (Disease Ontology:DOID:5845); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); rheumatoid arthritis (Disease Ontology:DOID:7148); end stage renal disease (Disease Ontology:DOID:783); chronic rhinitis (Disease Ontology:DOID:8252); intermediate coronary syndrome (Disease Ontology:DOID:8805); diabetic retinopathy (Disease Ontology:DOID:8947); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898); hepatopulmonary syndrome (Disease Ontology:DOID:900); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary embolism (Disease Ontology:DOID:9477); neovascular inflammatory vitreoretinopathy (Disease Ontology:DOID:9719); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24323); (R-RNO-375276); (R-RNO-416476)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "1840483;2039460;26479776;34021781;36450128;36942826;37978036;38824487;9508787", "class_list": "", "function": "CEBPB/POU2F2 modulates endothelin 1 expression in prehypertensive SHR vascular smooth muscle cells. Publication Status: Online-Only, [RefSeq, PubMed]; ET1 acts as a potential plasma biomarker and therapeutic target in deep venous thrombosis rat model., [RefSeq, PubMed]; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G protein-coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Also binds the DEAR/FBXW7-AS1 receptor (PubMed:9508787). Promotes mesenteric arterial wall remodeling via activation of ROCK signaling and subsequent colocalization of NFATC3 with F-actin filaments (By similarity). NFATC3 then translocates to the nucleus where it subsequently promotes the transcription of the smooth muscle hypertrophy and differentiation marker ACTA2 (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; Indoxyl sulfate enhances endothelin-1-induced contraction via impairment of NO/cGMP signaling in rat aorta. Erratum:[Pflugers Arch. 2021 Aug;473(8):1329. doi: 10.1007/s00424-021-02587-2. PMID: 34137923], [RefSeq, PubMed]; RCOR1 improves neurobehaviors and neuron injury in rat cerebral palsy by Endothelin-1 targeting-induced Akt/GSK-3beta pathway upregulation., [RefSeq, PubMed]; The circadian clock protein PER1 is important in maintaining endothelin axis regulation in Dahl salt-sensitive rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 61, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005125 cytokine activity;GO:0005179 hormone activity;GO:0048018 receptor ligand activity;GO:0031707 endothelin A receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0045178 basal part of cell;GO:0048237 rough endoplasmic reticulum lumen;GO:0033093 Weibel-Palade body", "go_biological_process": "GO:0030878 thyroid gland development;GO:0071559 response to transforming growth factor beta;GO:0086100 endothelin receptor signaling pathway;GO:0042045 epithelial fluid transport;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P22388-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51907-1", "uniprot_id": [ { "id": "EAA3_RAT", "url": "https://www.uniprot.org/uniprot/P51907", "type": "external" } ], "mass": 56772.0, "length": 523, "protein_name": "Excitatory amino acid transporter 3", "gene_name": "Slc1a1", "organism": "Rat", "refseq_name": "excitatory amino acid transporter 3", "refseq_ac": [ { "id": "NP_037164", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037164", "type": "external" } ], "gene_names_uniprotkb": "Slc1a1; Eaac1; Eaat3", "gene_names_refseq": "Eaac1; Eaat3; REAAC1; Slc1a1", "protein_names_uniprotkb": "Excitatory amino acid transporter 3; Excitatory amino-acid carrier 1; Sodium-dependent glutamate/aspartate transporter 3; Solute carrier family 1 member 1", "protein_names_refseq": "Solute carrier family 1 A1 (brain glutamate transporter); excitatory amino acid transporter 3; excitatory amino-acid carrier 1; sodium-dependent glutamate/aspartate transporter 3; solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1", "tax_id": 10116, "disease": "autoimmune glomerulonephritis (Disease Ontology:DOID:0040094); episodic ataxia type 6 (Disease Ontology:DOID:0050994); dicarboxylic aminoaciduria (Disease Ontology:DOID:0060650); schizophrenia 18 (Disease Ontology:DOID:0070093); neurodegenerative disease (Disease Ontology:DOID:1289); low tension glaucoma (Disease Ontology:DOID:13544); epilepsy (Disease Ontology:DOID:1826); multiple system atrophy (Disease Ontology:DOID:4752)", "pathway": " (rno:25550); (R-RNO-210500); (R-RNO-9958863)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "11242046;19720795;22673903;27507301;32827867;33550531;8613726;8738164;8747153;8772431;9011753", "class_list": "", "function": "MiR-101b targets the neuronal glutamate transporter SLC1A1. Both mRNA and protein levels of SLC1A1 were found to be upregulated in the prefrontal cortex of rats genetically predisposed to develop major depressive disorder. Publication Status: Online-Only, [RefSeq, PubMed]; NCX1 and EAAC1 transporters are involved in the protective action of glutamate in an in vitro Alzheimer's disease-like model., [RefSeq, PubMed]; Pre-Steady-State Kinetics and Reverse Transport in Rat Glutamate Transporter EAAC1 with an Immobilized Transport Domain., [RefSeq, PubMed]; Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:11242046, PubMed:9011753). Can also transport L-cysteine. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport. Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli (By similarity). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity). Contributes to glutathione biosynthesis and protection against oxidative stress via its role in L-glutamate and L-cysteine transport (By similarity). Negatively regulated by ARL6IP5 (PubMed:11242046)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O88389;Q63727;Q9JJP8", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0005253 monoatomic anion channel activity;GO:0015108 chloride transmembrane transporter activity;GO:0005314 high-affinity L-glutamate transmembrane transporter activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0006750 glutathione biosynthetic process;GO:0071577 zinc ion transmembrane transport;GO:0071242 cellular response to ammonium ion;GO:0007611 learning or memory;GO:0007613 memory", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P51907-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55054-1", "uniprot_id": [ { "id": "FABP9_RAT", "url": "https://www.uniprot.org/uniprot/P55054", "type": "external" } ], "mass": 15089.0, "length": 132, "protein_name": "Fatty acid-binding protein 9", "gene_name": "Fabp9", "organism": "Rat", "refseq_name": "fatty acid-binding protein 9", "refseq_ac": [ { "id": "NP_074045", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_074045", "type": "external" } ], "gene_names_uniprotkb": "Fabp9; Perf15", "gene_names_refseq": "Fabp9; Tlbp", "protein_names_uniprotkb": "Fatty acid-binding protein 9; 15 kDa perforatorial protein; PERF 15; T-FABP; TLBP; Testis lipid-binding protein; Testis-type fatty acid-binding protein", "protein_names_refseq": "15 kDa perforatorial protein; PERF 15; T-FABP; fatty acid binding protein 9, testis; fatty acid-binding protein 9; testis lipid-binding protein; testis-type fatty acid-binding protein", "tax_id": 10116, "disease": "", "pathway": " (rno:64822); (R-RNO-163560)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "22673903;7948479;7958448;9283004", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q68G09", "ec_number_list": [], "go_molecular_function": "GO:0036041 long-chain fatty acid binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0001675 acrosome assembly;GO:0015909 long-chain fatty acid transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P55054-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70600-1", "uniprot_id": [ { "id": "FAK2_RAT", "url": "https://www.uniprot.org/uniprot/P70600", "type": "external" } ], "mass": 115784.0, "length": 1009, "protein_name": "Protein-tyrosine kinase 2-beta", "gene_name": "Ptk2b", "organism": "Rat", "refseq_name": "protein-tyrosine kinase 2-beta", "refseq_ac": [ { "id": "NP_059014", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059014", "type": "external" } ], "gene_names_uniprotkb": "Ptk2b; Fak2; Pyk2", "gene_names_refseq": "CAK beta; CAKB; CAKbeta; Ptk2b; Pyk2", "protein_names_uniprotkb": "Protein-tyrosine kinase 2-beta; 2.7.10.2; CADTK; CAK-beta; CAKB; Calcium-dependent tyrosine kinase; Calcium-regulated non-receptor proline-rich tyrosine kinase; Cell adhesion kinase beta; FADK 2; Focal adhesion kinase 2; Proline-rich tyrosine kinase 2", "protein_names_refseq": "CADTK; CAK-beta; FADK 2; PTK2 protein tyrosine kinase 2 beta; PTK2B protein tyrosine kinase 2 beta; calcium-dependent tyrosine kinase; calcium-regulated non-receptor proline-rich tyrosine kinase; cell adhesion kinase beta; focal adhesion kinase 2; proline-rich tyrosine kinase 2; protein-tyrosine kinase 2-beta", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283); hypertension (Disease Ontology:DOID:10763); nephritis (Disease Ontology:DOID:10952); diabetic angiopathy (Disease Ontology:DOID:11713); breast cancer (Disease Ontology:DOID:1612); status epilepticus (Disease Ontology:DOID:1824); brain ischemia (Disease Ontology:DOID:2316); glomerulonephritis (Disease Ontology:DOID:2921); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780)", "pathway": " (rno:50646); (R-RNO-391160); (R-RNO-4420097); (R-RNO-9013420); (R-RNO-9020558)", "pathway_count": 5, "publication_count": 32, "publication_id_list": "11352655;11739373;11739395;12097497;12967635;15236860;15705590;15911746;15970382;16574377;20071509;20849950;21258655;21451101;22673903;22802128;24718602;24884636;25347863;26704905;31213568;32391653;32453021;37465947;38116014;7544443;7673154;8849729;8939945;9334354;9422762;9645946", "class_list": "", "function": "Acute stress induces visceral hypersensitivity via glucocorticoid receptor-mediated membrane insertion of TRPM8: Involvement of a non-receptor tyrosine kinase Pyk2., [RefSeq, PubMed]; Histone deacetylase-6 modulates amyloid beta-induced cognitive dysfunction rats by regulating PTK2B., [RefSeq, PubMed]; Inhibition of Pyk2 Improves Cx43 Intercalated Disc Localization, Infarct Size, and Cardiac Function in Rats With Heart Failure., [RefSeq, PubMed]; Inhibition of focal adhesion kinase 2 results in a macrophage polarization shift to M2 which attenuates local and systemic inflammation and reduces heterotopic ossification after polysystem extremity trauma. Publication Status: Online-Only, [RefSeq, PubMed]; Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G protein-coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376' (By similarity). Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2 (By similarity)., [UniProtKB, PubMed]; These findings indicate that hnRNP K mediates the synaptic distribution of Pyk2 synthesis, and hence the synaptic incorporation of GluN2B-containing NMDARs, induced by BDNF, which may affect LTP and synaptic plasticity. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88489;Q3T1H4;Q63201", "ec_number_list": [ { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0017146 NMDA selective glutamate receptor complex;GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0086100 endothelin receptor signaling pathway;GO:0001525 angiogenesis;GO:0002931 response to ischemia;GO:0006468 protein phosphorylation;GO:0007015 actin filament organization", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "P70600-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q04631-1", "uniprot_id": [ { "id": "FNTA_RAT", "url": "https://www.uniprot.org/uniprot/Q04631", "type": "external" } ], "mass": 44049.0, "length": 377, "protein_name": "Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha", "gene_name": "Fnta", "organism": "Rat", "refseq_name": "protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha", "refseq_ac": [ { "id": "NP_036979", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036979", "type": "external" } ], "gene_names_uniprotkb": "Fnta", "gene_names_refseq": "Fnta; PFAS", "protein_names_uniprotkb": "Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha; 2.5.1.58; 2.5.1.59; CAAX farnesyltransferase subunit alpha; FTase-alpha; GGTase-I-alpha; Ras proteins prenyltransferase subunit alpha; Type I protein geranyl-geranyltransferase subunit alpha", "protein_names_refseq": "CAAX farnesyltransferase subunit alpha; FTase-alpha; Farnesyltransferase, subunit alpha; GGTase-I-alpha; farnesyltransferase, CAAX box, alpha; protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha; ras proteins prenyltransferase subunit alpha; type I protein geranyl-geranyltransferase subunit alpha", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); traumatic brain injury (Disease Ontology:DOID:0081292); extrapyramidal and movement disease (Disease Ontology:DOID:13839); major depressive disorder (Disease Ontology:DOID:1470); autoimmune hepatitis (Disease Ontology:DOID:2048); opiate dependence (Disease Ontology:DOID:2559); asthma (Disease Ontology:DOID:2841); rhinitis (Disease Ontology:DOID:4483); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); acute myeloid leukemia (Disease Ontology:DOID:9119); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:25318); (R-RNO-111465); (R-RNO-2514859); (R-RNO-9648002); (R-RNO-9953170)", "pathway_count": 5, "publication_count": 19, "publication_id_list": "10377218;10673434;11687658;12374986;12657282;12667062;14609943;15170324;15451670;1763049;18844669;19219049;22963166;23534605;29282289;9065406;9609683;9657673;9843427", "class_list": "", "function": "Data suggest that substrate specificity of protein farnesyltransferase (subunits Fnta plus Fntb) is extensive; these results expand the scope of the potential prenylated proteome in this species. (Fnta = farnesyltransferase CAAX box alpha protein; Fntb = farnesyltransferase CAAX box beta protein), [RefSeq, PubMed]; Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; GGTase-1 mediates brain derived neurotrophic factor (BDNF)-induced neuronal synaptogenesis in the hippocampus., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.5.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.59", "type": "external" }, { "id": "3.4.22.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.56", "type": "external" }, { "id": "2.5.1.58", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.58", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" } ], "go_molecular_function": "GO:0004660 protein farnesyltransferase activity;GO:0004661 protein geranylgeranyltransferase activity;GO:0004662 CAAX-protein geranylgeranyltransferase activity;GO:0004663 Rab geranylgeranyltransferase activity;GO:0060090 molecular adaptor activity", "go_cellular_component": "GO:0005953 CAAX-protein geranylgeranyltransferase complex;GO:0005965 protein farnesyltransferase complex;GO:0005737 cytoplasm;GO:0005875 microtubule associated complex;GO:0005886 plasma membrane", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0018343 protein farnesylation;GO:0045787 positive regulation of cell cycle;GO:0035022 positive regulation of Rac protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q04631-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RJN7-1", "uniprot_id": [ { "id": "GAR1A_RAT", "url": "https://www.uniprot.org/uniprot/Q5RJN7", "type": "external" } ], "mass": 32795.0, "length": 295, "protein_name": "Golgi-associated RAB2 interactor protein 1A", "gene_name": "Garin1a", "organism": "Rat", "refseq_name": "Golgi-associated RAB2 interactor protein 1A", "refseq_ac": [ { "id": "NP_001019494", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019494", "type": "external" } ], "gene_names_uniprotkb": "Garin1a; Fam137b; Fam71f2", "gene_names_refseq": "Fam71f2; Garin1a; Tdrns18l2", "protein_names_uniprotkb": "Golgi-associated RAB2 interactor protein 1A", "protein_names_refseq": "Golgi associated RAB2 interactor protein 1A; Golgi-associated RAB2 interactor protein 1A; family with sequence similarity 71, member F2; protein FAM71F2; testes development-related NYD-SP18-like 2", "tax_id": 10116, "disease": "", "pathway": " (rno:500060)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "RAB2B effector protein required for accurate acrosome formation and normal male fertility., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus", "go_biological_process": "GO:0001675 acrosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5RJN7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XI67-1", "uniprot_id": [ { "id": "FBX30_RAT", "url": "https://www.uniprot.org/uniprot/Q5XI67", "type": "external" } ], "mass": 82011.0, "length": 742, "protein_name": "F-box only protein 30", "gene_name": "Fbxo30", "organism": "Rat", "refseq_name": "F-box only protein 30", "refseq_ac": [ { "id": "NP_001007691", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007691", "type": "external" } ], "gene_names_uniprotkb": "Fbxo30", "gene_names_refseq": "Fbxo30", "protein_names_uniprotkb": "F-box only protein 30", "protein_names_refseq": "F-box only protein 30", "tax_id": 10116, "disease": "", "pathway": " (rno:308283); (R-RNO-8951664); (R-RNO-983168)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Required for muscle atrophy following denervation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "", "go_biological_process": "GO:0007059 chromosome segregation;GO:0016567 protein ubiquitination;GO:0006325 chromatin organization;GO:0030261 chromosome condensation;GO:0010467 gene expression", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XI67-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63470-1", "uniprot_id": [ { "id": "DYR1A_RAT", "url": "https://www.uniprot.org/uniprot/Q63470", "type": "external" } ], "mass": 85541.0, "length": 763, "protein_name": "Dual specificity tyrosine-phosphorylation-regulated kinase 1A", "gene_name": "Dyrk1a", "organism": "Rat", "refseq_name": "dual specificity tyrosine-phosphorylation-regulated kinase 1A", "refseq_ac": [ { "id": "NP_036923", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036923", "type": "external" } ], "gene_names_uniprotkb": "Dyrk1a; Dyrk", "gene_names_refseq": "Dyrk1a; Dyrk; PSK47", "protein_names_uniprotkb": "Dual specificity tyrosine-phosphorylation-regulated kinase 1A; 2.7.11.23; 2.7.12.1; Dual specificity YAK1-related kinase; MNBH; Protein kinase minibrain homolog; RP86", "protein_names_refseq": "Dual Specificity Yak1-related kinase; MNBH; RP86; dual specificity tyrosine-phosphorylation-regulated kinase 1A; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A; protein kinase minibrain homolog", "tax_id": 10116, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888); autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal dominant intellectual developmental disorder 7 (Disease Ontology:DOID:0070037); intellectual disability (Disease Ontology:DOID:1059); hypertension (Disease Ontology:DOID:10763); dilated cardiomyopathy (Disease Ontology:DOID:12930); Down syndrome (Disease Ontology:DOID:14250); renovascular hypertension (Disease Ontology:DOID:1591); brain ischemia (Disease Ontology:DOID:2316); Papillon-Lefevre disease (Disease Ontology:DOID:3389); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); hyperhomocysteinemia (Disease Ontology:DOID:9279); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25255); (R-RNO-1538133)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "11877424;18938227;22767602;22998443;37501148;37702441;8631952;9748265", "class_list": "", "function": "Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities (PubMed:18938227, PubMed:22998443, PubMed:8631952, PubMed:9748265). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3 (By similarity). Plays an important role in double-strand breaks (DSBs) repair following DNA damage (By similarity). Mechanistically, phosphorylates RNF169 and increases its ability to block accumulation of TP53BP1 at the DSB sites thereby promoting homologous recombination repair (HRR) (By similarity). Also acts as a positive regulator of transcription by acting as a CTD kinase that mediates phosphorylation of the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A (By similarity). May play a role in a signaling pathway regulating nuclear functions of cell proliferation (By similarity). Modulates alternative splicing by phosphorylating the splice factor SRSF6 (PubMed:22767602). Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits p53/TP53 activity and apoptosis (By similarity). Phosphorylates SEPTIN4, SEPTIN5 and SF3B1 at 'Thr-434' (PubMed:18938227)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Mechanism of DYRK1a in myocardial ischemia-reperfusion injury by regulating ferroptosis of cardiomyocytes., [RefSeq, PubMed]; The result suggests that Mnbk/Dyrk1A can play a dual role in regulating the interaction of dynamin 1 with amphiphysin 1, [RefSeq, PubMed]; The role of NPY2R/NFATc1/DYRK1A regulatory axis in sebaceous glands for sebum synthesis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003779 actin binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005874 microtubule", "go_biological_process": "GO:0033120 positive regulation of RNA splicing;GO:0006351 DNA-templated transcription;GO:0006468 protein phosphorylation;GO:0018108 peptidyl-tyrosine phosphorylation;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q63470-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66HH2-1", "uniprot_id": [ { "id": "EMP2_RAT", "url": "https://www.uniprot.org/uniprot/Q66HH2", "type": "external" } ], "mass": 19649.0, "length": 172, "protein_name": "Epithelial membrane protein 2", "gene_name": "Emp2", "organism": "Rat", "refseq_name": "epithelial membrane protein 2", "refseq_ac": [ { "id": "NP_001007722", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007722", "type": "external" } ], "gene_names_uniprotkb": "Emp2", "gene_names_refseq": "EMP-2; Emp2", "protein_names_uniprotkb": "Epithelial membrane protein 2; EMP-2", "protein_names_refseq": "epithelial membrane protein 2", "tax_id": 10116, "disease": "nephrotic syndrome type 10 (Disease Ontology:DOID:0080386); placental insufficiency (Disease Ontology:DOID:3891)", "pathway": " (rno:360468)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "24814193;34495369", "class_list": "", "function": "Functions as a key regulator of cell membrane composition by regulating protein surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion. Regulates transepithelial migration of neutrophils into the alveolar lumen, potentially via mediation of cell surface expression of adhesion markers and lipid raft formation (By similarity). Negatively regulates caveolae formation by reducing CAV1 expression and CAV1 amount by increasing lysosomal degradation (By similarity). Facilitates surface trafficking and the formation of lipid rafts bearing GPI-anchor proteins (By similarity). Regulates surface expression of MHC1 and ICAM1 proteins increasing susceptibility to T-cell mediated cytotoxicity (By similarity). Regulates the plasma membrane expression of the integrin heterodimers ITGA6-ITGB1, ITGA5-ITGB3 and ITGA5-ITGB1 resulting in modulation of cell-matrix adhesion (By similarity). Also regulates many processes through PTK2 (By similarity). Regulates blood vessel endothelial cell migration and angiogenesis by regulating VEGF protein expression through PTK2 activation (By similarity). Regulates cell contraction through PTK2 activation (By similarity). Regulates focal adhesion density, F-actin conformation and cell adhesion capacity through interaction with PTK2 (By similarity). Positively regulates cell proliferation (By similarity). Plays a role during cell death and cell blebbing. Promotes angiogenesis and vasculogenesis through induction of VEGFA via a HIF1A-dependent pathway (By similarity). Also plays a role in embryo implantation by regulating surface trafficking of integrin heterodimer ITGA5-ITGB3 (By similarity). Plays a role in placental angiogenesis and uterine natural killer cell regulation at the maternal-fetal placental interface, however not required in the maternal tissues for a viable pregnancy (By similarity). Involved in the early stages of embryogenic development and cardiogenesis, potentially via regulation of epithelial-mesenchymal transition timing (By similarity). May play a role in glomerular filtration (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; MiR-340-5p mediates the therapeutic effect of mesenchymal stem cells on corneal neovascularization., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0019900 kinase binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0007015 actin filament organization;GO:0007155 cell adhesion;GO:0008284 positive regulation of cell population proliferation;GO:0072659 protein localization to plasma membrane;GO:0003093 regulation of glomerular filtration", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q66HH2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R560-1", "uniprot_id": [ { "id": "ANKR1_RAT", "url": "https://www.uniprot.org/uniprot/Q8R560", "type": "external" } ], "mass": 36064.0, "length": 319, "protein_name": "Ankyrin repeat domain-containing protein 1", "gene_name": "Ankrd1", "organism": "Rat", "refseq_name": "ankyrin repeat domain-containing protein 1", "refseq_ac": [ { "id": "NP_037352", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037352", "type": "external" } ], "gene_names_uniprotkb": "Ankrd1; Carp", "gene_names_refseq": "Alrp; Ankrd1; Carp; Crap; MARP", "protein_names_uniprotkb": "Ankyrin repeat domain-containing protein 1; Cardiac adriamycin-responsive protein; Cardiac ankyrin repeat protein", "protein_names_refseq": "ankyrin repeat domain 1 (cardiac muscle); ankyrin repeat domain-containing protein 1; ankyrin-like repeat protein; cardiac adriamycin-responsive protein; cardiac ankyrin repeat protein; cardiac responsive adriamycin protein; muscle ankyrin repeat protein", "tax_id": 10116, "disease": "hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); spinal muscular atrophy (Disease Ontology:DOID:12377); dilated cardiomyopathy (Disease Ontology:DOID:12930); nemaline myopathy (Disease Ontology:DOID:3191); congenital structural myopathy (Disease Ontology:DOID:422)", "pathway": " (rno:27064)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "22532871;22892129;23811403;25089522;9043061;9278441", "class_list": "", "function": "Ankrd1 binds to and directly regulates the transcriptional activity of the human androgen receptor in cultured rat myoblasts, whereas Ankrd2 does not., [RefSeq, PubMed]; May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Overexpression of Ankrd1 exacerbates pathological cardiac remodeling through the enhancement of cytosolic translocation of CARP and up-regulation of calcineurin. Publication Status: Online-Only, [RefSeq, PubMed]; The 26S proteasome is the dominant regulator of Ankrd1/CARP degradation, and that Ankrd1/CARP half-life is significantly longer in cardiomyocytes (h) than endothelial cells (min)., [RefSeq, PubMed]; These data demonstrate co-dependent roles for GATA4 and CARP in regulating sarcomere gene expression and maintaining sarcomeric organization in cardiomyocytes in culture., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9Z1F0", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003713 transcription coactivator activity;GO:0003779 actin binding;GO:0003714 transcription corepressor activity;GO:0042826 histone deacetylase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010976 positive regulation of neuron projection development;GO:0043065 positive regulation of apoptotic process;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8R560-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0L5-1", "uniprot_id": [ { "id": "EREG_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z0L5", "type": "external" } ], "mass": 18404.0, "length": 162, "protein_name": "Proepiregulin", "gene_name": "Ereg", "organism": "Rat", "refseq_name": "proepiregulin preproprotein", "refseq_ac": [ { "id": "NP_067721", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067721", "type": "external" } ], "gene_names_uniprotkb": "Ereg", "gene_names_refseq": "Ereg", "protein_names_uniprotkb": "Proepiregulin", "protein_names_refseq": "preproprotein; proepiregulin preproprotein; proepiregulin", "tax_id": 10116, "disease": "extrapulmonary tuberculosis (Disease Ontology:DOID:0050598); pulmonary tuberculosis (Disease Ontology:DOID:2957); tuberculosis (Disease Ontology:DOID:399); cholesteatoma (Disease Ontology:DOID:869)", "pathway": " (rno:59325); (R-RNO-1227986); (R-RNO-1236394); (R-RNO-1250196); (R-RNO-1250342); (R-RNO-1250347); (R-RNO-1257604); (R-RNO-177929); (R-RNO-179812); (R-RNO-180292); (R-RNO-180336); (R-RNO-182971); (R-RNO-1963640); (R-RNO-1963642); (R-RNO-212718); (R-RNO-5673001); (R-RNO-6785631); (R-RNO-6811558); (R-RNO-8847993); (R-RNO-8856825); (R-RNO-8856828); (R-RNO-8863795); (R-RNO-9009391)", "pathway_count": 23, "publication_count": 4, "publication_id_list": "12446600;24631357;31062344;9990076", "class_list": "", "function": "Epiregulin is a potent autocrine vascular smooth muscle cell mitogen induced by angiotensin II, endothelin-1, and thrombin, [RefSeq, PubMed]; Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation (PubMed:9990076). Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation (PubMed:24631357)., [UniProtKB, PubMed, PubMed]; Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation. Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation., [UniProtKB, UniProtKB]; The silencing of EREG inhibits angiogenesis and promotes left ventricular remodeling by disrupting the ERK1/2 signaling pathway, providing a novel therapeutic target for limiting acute myocardial infarction., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005154 epidermal growth factor receptor binding;GO:0008083 growth factor activity;GO:0030297 transmembrane receptor protein tyrosine kinase activator activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0007267 cell-cell signaling;GO:0008284 positive regulation of cell population proliferation;GO:0008285 negative regulation of cell population proliferation;GO:0032755 positive regulation of interleukin-6 production", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9Z0L5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62728-1", "uniprot_id": [ { "id": "PTN21_RAT", "url": "https://www.uniprot.org/uniprot/Q62728", "type": "external" } ], "mass": 133412.0, "length": 1175, "protein_name": "Tyrosine-protein phosphatase non-receptor type 21", "gene_name": "Ptpn21", "organism": "Rat", "refseq_name": "tyrosine-protein phosphatase non-receptor type 21", "refseq_ac": [ { "id": "NP_598229", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598229", "type": "external" } ], "gene_names_uniprotkb": "Ptpn21; Ptp2e", "gene_names_refseq": "Ptp2E; Ptpn21", "protein_names_uniprotkb": "Tyrosine-protein phosphatase non-receptor type 21; 3.1.3.48; Protein-tyrosine phosphatase 2E", "protein_names_refseq": "protein-tyrosine phosphatase 2E; tyrosine-protein phosphatase non-receptor type 21", "tax_id": 10116, "disease": "", "pathway": " (rno:171070)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15240697;19103603;22673903;28843827;7805871", "class_list": "", "function": "Expression of Ptpn21 decreases 8-fold at night in the rat pineal gland relative to day values. This appears to reflect negative effects of norepinephrine acting through a cyclic AMP mechanism., [RefSeq, PubMed]; PTPN21 protects PC12 cell against oxygen-glucose deprivation by activating cdk5 through ERK1/2 signaling pathway, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q62732", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" } ], "go_molecular_function": "GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005737 cytoplasm", "go_biological_process": "GO:0007010 cytoskeleton organization;GO:0035332 positive regulation of hippo signaling", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q62728-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RKH1-1", "uniprot_id": [ { "id": "PRP4K_RAT", "url": "https://www.uniprot.org/uniprot/Q5RKH1", "type": "external" } ], "mass": 117007.0, "length": 1007, "protein_name": "Serine/threonine-protein kinase PRP4 homolog", "gene_name": "Prp4k; Prpf4b", "organism": "Rat", "refseq_name": "serine/threonine-protein kinase PRP4 homolog", "refseq_ac": [ { "id": "NP_001011923", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011923", "type": "external" } ], "gene_names_uniprotkb": "Prp4k; Prpf4b; Prpf4b", "gene_names_refseq": "Prp4k; Prpf4b", "protein_names_uniprotkb": "Serine/threonine-protein kinase PRP4 homolog; 2.7.11.1; PRP4 pre-mRNA-processing factor 4 homolog", "protein_names_refseq": "PRP4 pre-mRNA processing factor 4 homolog B; PRP4 pre-mRNA-processing factor 4 homolog; serine/threonine-protein kinase PRP4 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:291078)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16641100;22673903", "class_list": "", "function": "Serine/threonine kinase involved in spliceosomal assembly as well as mitosis and signaling regulation. Connects chromatin mediated regulation of transcription and pre-mRNA splicing. During spliceosomal assembly, interacts with and phosphorylates PRPF6 and PRPF31, components of the U4/U6-U5 tri-small nuclear ribonucleoprotein (snRNP), to facilitate the formation of the spliceosome B complex. Plays a role in regulating transcription and the spindle assembly checkpoint (SAC). Associates with U5 snRNP and NCOR1 deacetylase complexes which may allow a coordination of pre-mRNA splicing with chromatin remodeling events involved in transcriptional regulation. Associates and probably phosphorylates SMARCA4 and NCOR1. Phosphorylates SRSF1. Associates with kinetochores during mitosis and is necessary for recruitment and maintenance of the checkpoint proteins such as MAD1L1 and MAD12L1 at the kinetochores. Phosphorylates and regulates the activity of the transcription factors such as ELK1 and KLF13. Phosphorylates nuclear YAP1 and WWTR1/TAZ which induces nuclear exclusion and regulates Hippo signaling pathway, involved in tissue growth control., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 37, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0000776 kinetochore;GO:0071013 catalytic step 2 spliceosome;GO:0071016 U12-type precatalytic spliceosome", "go_biological_process": "GO:0000244 spliceosomal tri-snRNP complex assembly;GO:0046827 positive regulation of protein export from nucleus;GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint;GO:0000387 spliceosomal snRNP assembly;GO:0035332 positive regulation of hippo signaling", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5RKH1-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70501-1", "uniprot_id": [ { "id": "RBM10_RAT", "url": "https://www.uniprot.org/uniprot/P70501", "type": "external" } ], "mass": 94388.0, "length": 852, "protein_name": "RNA-binding protein 10", "gene_name": "Rbm10", "organism": "Rat", "refseq_name": "RNA-binding protein 10 isoform 1", "refseq_ac": [ { "id": "NP_690600", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_690600", "type": "external" } ], "gene_names_uniprotkb": "Rbm10", "gene_names_refseq": "Rbm10", "protein_names_uniprotkb": "RNA-binding protein 10; RNA-binding motif protein 10; RNA-binding protein S1-1", "protein_names_refseq": "RNA-binding protein 10 isoform 1; RNA-binding protein 10; RNA-binding protein S1-1; S1-1 protein from liver", "tax_id": 10116, "disease": "TARP syndrome (Disease Ontology:DOID:0111780); lung cancer (Disease Ontology:DOID:1324); lung adenocarcinoma (Disease Ontology:DOID:3910); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:64510); (R-RNO-72163); (R-RNO-72203); (R-RNO-9770562)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "19508861;22673903;8760884", "class_list": "", "function": "Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (By similarity). May be involved in post-transcriptional processing, most probably in mRNA splicing (By similarity). Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (PubMed:8760884). May bind to specific miRNA hairpins (By similarity)., [UniProtKB, UniProtKB, PubMed]; Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3'. May be involved in post-transcriptional processing, most probably in mRNA splicing. Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A). May bind to specific miRNA hairpins., [UniProtKB, UniProtKB]; Overexpression of S1-1 sense resulted in VSMC in significant stabilization of AT1 receptor mRNA., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0003727 single-stranded RNA binding;GO:0035198 miRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0016607 nuclear speck;GO:0032991 protein-containing complex", "go_biological_process": "GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development;GO:0060379 cardiac muscle cell myoblast differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:0048255 mRNA stabilization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P70501-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6MG48-1", "uniprot_id": [ { "id": "PRC2A_RAT", "url": "https://www.uniprot.org/uniprot/Q6MG48", "type": "external" } ], "mass": 229047.0, "length": 2161, "protein_name": "Protein PRRC2A", "gene_name": "Prrc2a", "organism": "Rat", "refseq_name": "protein PRRC2A", "refseq_ac": [ { "id": "NP_997627", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997627", "type": "external" } ], "gene_names_uniprotkb": "Prrc2a; Bat2", "gene_names_refseq": "Bat2; Prrc2a", "protein_names_uniprotkb": "Protein PRRC2A; HLA-B-associated transcript 2; Proline-rich and coiled-coil-containing protein 2A", "protein_names_refseq": "HLA-B-associated transcript 2; large proline-rich protein BAT2; proline-rich and coiled-coil-containing protein 2A; protein PRRC2A", "tax_id": 10116, "disease": "type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:294250)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15060004;16641100;22673903;38843836", "class_list": "", "function": "May play a role in the regulation of pre-mRNA splicing., [UniProtKB]", "predicted_glycosites": 11, "predicted_n_glycosites": 0, "predicted_o_glycosites": 11, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 45, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6MG48-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JPQ4-1", "uniprot_id": [ { "id": "TRI72_RAT", "url": "https://www.uniprot.org/uniprot/A0JPQ4", "type": "external" } ], "mass": 52832.0, "length": 477, "protein_name": "Tripartite motif-containing protein 72", "gene_name": "Trim72", "organism": "Rat", "refseq_name": "tripartite motif-containing protein 72", "refseq_ac": [ { "id": "NP_001071143", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071143", "type": "external" } ], "gene_names_uniprotkb": "Trim72; Mg53", "gene_names_refseq": "RGD1562778; Trim72", "protein_names_uniprotkb": "Tripartite motif-containing protein 72; 2.3.2.27; Mg53; Mitsugumin-53", "protein_names_refseq": "mg53; mitsugumin-53; tripartite motif containing 72, E3 ubiquitin protein ligase; tripartite motif-containing protein 72", "tax_id": 10116, "disease": "", "pathway": " (rno:365377)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "20516375;22673903;27843952;29233682;30760025;32796321;37169128", "class_list": "", "function": "MG53 ameliorates nerve injury induced neuropathic pain through the regulation of Nrf2/HO-1 signaling in rats., [RefSeq, PubMed]; MG53, a member of the muscle-specific transmembrane adaptor molecule (TRIM) protein family, is a crucial component of the cardiac ischemic preconditioning response., [RefSeq, PubMed]; Muscle-specific E3 ubiquitin-protein ligase that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites (By similarity). Its ubiquitination activity is mediated by E2 ubiquitin-conjugating enzymes UBE2D1, UBE2D2 and UBE2D3 (By similarity). Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site (By similarity). This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation (By similarity). Probably acts upstream of the Ca(2+)-dependent membrane resealing process (By similarity). Required for transport of DYSF to sites of cell injury during repair patch formation (By similarity). Regulates membrane budding and exocytosis (By similarity). May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity)., [UniProtKB, UniProtKB]; TRIM72 mediates lung epithelial cell death upon hyperoxia exposure., [RefSeq, PubMed]; These findings establish MG53 as a novel regulator of KChIP2 and Ito,f by modulating NF-kappaB activity and reveal its critical role in electrophysiological remodeling in cardiac hypertrophy., [RefSeq, PubMed]; These results suggest that an 8-week swimming exercise improves HFD-induced insulin resistance maybe through a reduction of TRIM72 in skeletal muscle and enhancement of AKT signal transduction., [RefSeq, PubMed]; This suggests that MG53 is a potential regulator of atrial fibrosis induced by the TGF-beta1/Smad pathway in patients with atrial fibrillation ., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0061630 ubiquitin protein ligase activity;GO:0001786 phosphatidylserine binding;GO:0031624 ubiquitin conjugating enzyme binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030659 cytoplasmic vesicle membrane;GO:0042383 sarcolemma", "go_biological_process": "GO:0001778 plasma membrane repair;GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0045087 innate immune response;GO:0051260 protein homooligomerization;GO:0007517 muscle organ development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A0JPQ4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKS6-1", "uniprot_id": [ { "id": "PCLO_RAT", "url": "https://www.uniprot.org/uniprot/Q9JKS6", "type": "external" } ], "mass": 552716.0, "length": 5085, "protein_name": "Protein piccolo", "gene_name": "Pclo", "organism": "Rat", "refseq_name": "protein piccolo isoform 1", "refseq_ac": [ { "id": "NP_064483", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064483", "type": "external" } ], "gene_names_uniprotkb": "Pclo", "gene_names_refseq": "Pclo; aczonin", "protein_names_uniprotkb": "Protein piccolo; Aczonin; Multidomain presynaptic cytomatrix protein", "protein_names_refseq": "multidomain presynaptic cytomatrix protein Piccolo; presynaptic cytomatrix protein; protein piccolo isoform 1; protein piccolo-like; protein piccolo", "tax_id": 10116, "disease": "pontocerebellar hypoplasia type 3 (Disease Ontology:DOID:0060272)", "pathway": " (rno:56768)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10707984;11285225;12473661;14718922;18683930;22673903;22875941;23403927;25652077;27907191;29194628;31074746;32122952;38843836", "class_list": "", "function": "Loss of Piccolo Function in Rats Induces Cerebellar Network Dysfunction and Pontocerebellar Hypoplasia Type 3-like Phenotypes., [RefSeq, PubMed]; Piccolo is critical for the recycling and maintenance of synaptic vesicles. Publication Status: Online-Only, [RefSeq, PubMed]; Piccolo organizes the readily releasable pool of synaptic vesicles at the calyx of Held., [RefSeq, PubMed]; Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (PubMed:22875941). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (PubMed:22875941). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (PubMed:27907191). Organizes as well the readily releasable pool of synaptic vesicles and safeguards a fraction of them to be not immediately available for action potential-induced release (PubMed:29194628). Also functions in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy (PubMed:23403927, PubMed:27907191). Also mediates synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (PubMed:25652077)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; The findings provide a mechanism for the presynaptic targeting of Trio and support a model in which Piccolo and Bassoon play a role in regulating neurotransmission through interactions with proteins, including Trio, that modulate the dynamic assembly of F-actin during cycles of synaptic vesicle exo- and endocytosis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 16, "predicted_n_glycosites": 0, "predicted_o_glycosites": 16, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 66, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 16, "binding_glycan_count": 0, "secondary_ac_list": "Q9JLT1", "ec_number_list": [], "go_molecular_function": "GO:0098882 structural constituent of presynaptic active zone;GO:0008270 zinc ion binding;GO:0005509 calcium ion binding;GO:0005544 calcium-dependent phospholipid binding;GO:0005522 profilin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0098831 presynaptic active zone cytoplasmic component;GO:0005798 Golgi-associated vesicle;GO:0014069 postsynaptic density", "go_biological_process": "GO:0016080 synaptic vesicle targeting;GO:0097091 synaptic vesicle clustering;GO:0050808 synapse organization;GO:0098815 modulation of excitatory postsynaptic potential;GO:0007010 cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9JKS6-1", "record_type": "protein", "filter_code": "0000000.0100111.000100.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U1Z0-1", "uniprot_id": [ { "id": "RBGPR_RAT", "url": "https://www.uniprot.org/uniprot/Q5U1Z0", "type": "external" } ], "mass": 154431.0, "length": 1386, "protein_name": "Rab3 GTPase-activating protein non-catalytic subunit", "gene_name": "Rab3gap2", "organism": "Rat", "refseq_name": "rab3 GTPase-activating protein non-catalytic subunit", "refseq_ac": [ { "id": "NP_001035244", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035244", "type": "external" } ], "gene_names_uniprotkb": "Rab3gap2", "gene_names_refseq": "RGD1311518; Rab3gap2", "protein_names_uniprotkb": "Rab3 GTPase-activating protein non-catalytic subunit; Rab3 GTPase-activating protein 150 kDa subunit; Rab3-GAP p150; Rab3-GAP regulatory subunit; Rab3-GAP150", "protein_names_refseq": "RAB3 GTPase activating protein subunit 2; RAB3-GAP150; rab3 GTPase-activating protein 150 kDa subunit; rab3 GTPase-activating protein non-catalytic subunit; rab3-GAP p150; rab3-GAP regulatory subunit", "tax_id": 10116, "disease": "Warburg micro syndrome (Disease Ontology:DOID:0060237); Warburg micro syndrome 2 (Disease Ontology:DOID:0110717); Martsolf syndrome (Disease Ontology:DOID:0111586)", "pathway": " (rno:289350); (R-RNO-6811436); (R-RNO-8876198)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "11809763;22673903;9733780", "class_list": "", "function": "Regulatory subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of RAB3GAP1 and RAB3GAP2, which accelerates the otherwise slow GTP hydrolysis catalyzed by Rab proteins. The complex has GTPase-activating protein (GAP) activity towards various Rab3 subfamily members (RAB3A, RAB3B, RAB3C and RAB3D), RAB5A and RAB43, and has guanine nucleotide exchange factor (GEF) activity towards RAB18. The Rab3GAP complex acts as a GEF for RAB18 by promoting GDP release from RAB18 and the conversion of inactive RAB18-GDP to the active form RAB18-GTP. Recruits and stabilizes RAB18 at the cis-Golgi membrane in human fibroblasts where RAB18 is most likely activated. Also involved in RAB18 recruitment at the endoplasmic reticulum (ER) membrane where it maintains proper ER structure (By similarity). Required for normal eye and brain development (By similarity). May participate in neurodevelopmental processes such as cell proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0031267 small GTPase binding;GO:0030234 enzyme regulator activity;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005776 autophagosome", "go_biological_process": "GO:0097051 establishment of protein localization to endoplasmic reticulum membrane;GO:0043087 regulation of GTPase activity;GO:0016236 macroautophagy;GO:1903373 positive regulation of endoplasmic reticulum tubular network organization;GO:2000786 positive regulation of autophagosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5U1Z0-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63560-1", "uniprot_id": [ { "id": "MAP6_RAT", "url": "https://www.uniprot.org/uniprot/Q63560", "type": "external" } ], "mass": 100485.0, "length": 952, "protein_name": "Microtubule-associated protein 6", "gene_name": "Map6", "organism": "Rat", "refseq_name": "microtubule-associated protein 6 isoform 2", "refseq_ac": [ { "id": "NP_001385530", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001385530", "type": "external" } ], "gene_names_uniprotkb": "Map6; Mtap6", "gene_names_refseq": "Map6; Mtap6", "protein_names_uniprotkb": "Microtubule-associated protein 6; 145-kDa STOP; MAP-6; STOP145; STOP; Stable tubule-only polypeptide", "protein_names_refseq": "145-kDa STOP; MAP-6; STOP145; STOP; microtubule-associated protein 6 homolog; microtubule-associated protein 6 isoform 2; stable tubule-only polypeptide", "tax_id": 10116, "disease": "schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:29457)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "11413126;14724383;18683930;22673903;22750298;23831686;24357581;28521134;3456161;38843836;8700896;9660871", "class_list": "", "function": "Involved in microtubule stabilization in many cell types, including neuronal cells (PubMed:11413126, PubMed:28521134, PubMed:3456161, PubMed:8700896, PubMed:9660871). Specifically has microtubule cold stabilizing activity (PubMed:3456161). Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B (By similarity). Regulates KIF5A-mediated axonal cargo transport (PubMed:28521134). Regulates axonal growth during neuron polarization (PubMed:28521134)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; MAP6 is present at the Golgi complex and in secretory vesicles in unpolarized cells and re-distributed to newly forming axons, where it binds and stabilizes axonal microtubules. A palmitoylation cycle controls MAP6 membrane-microtubule shuttling and is required for its polarized distribution in axons., [RefSeq, PubMed]; Structural basis for the association of MAP6 protein with microtubules and its regulation by calmodulin., [RefSeq, PubMed]; The neuron-specific isoform of the stable tubule-only polypeptide (STOP) interacted with the SH3A domain of ITSN1. STOP and ITSN1 were shown to form a complex in vivo., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O88748;Q6AYX8", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0008017 microtubule binding", "go_cellular_component": "GO:0099503 secretory vesicle;GO:0005794 Golgi apparatus;GO:0005798 Golgi-associated vesicle;GO:0005874 microtubule;GO:0030424 axon", "go_biological_process": "GO:0048813 dendrite morphogenesis;GO:0000226 microtubule cytoskeleton organization;GO:0050772 positive regulation of axonogenesis;GO:0032418 lysosome localization;GO:0030705 cytoskeleton-dependent intracellular transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q63560-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6QGW5-1", "uniprot_id": [ { "id": "SRA1_RAT", "url": "https://www.uniprot.org/uniprot/Q6QGW5", "type": "external" } ], "mass": 24114.0, "length": 219, "protein_name": "Steroid receptor RNA activator 1", "gene_name": "Sra1", "organism": "Rat", "refseq_name": "steroid receptor RNA activator 1", "refseq_ac": [ { "id": "NP_899158", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_899158", "type": "external" } ], "gene_names_uniprotkb": "Sra1", "gene_names_refseq": "Sra1", "protein_names_uniprotkb": "Steroid receptor RNA activator 1; SRAP; Steroid receptor RNA activator protein", "protein_names_refseq": "SRAP; steroid receptor RNA activator 1; steroid receptor RNA activator protein", "tax_id": 10116, "disease": "congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (rno:252891)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12350225;15147866;22673903;31714481", "class_list": "", "function": "Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; Steroid receptor RNA activator affects the development of poststroke depression by regulating the peroxisome proliferator-activated receptor gamma signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q811X7", "ec_number_list": [], "go_molecular_function": "GO:0002153 steroid receptor RNA activator RNA binding;GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006915 apoptotic process;GO:0045662 negative regulation of myoblast differentiation;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6QGW5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O55000-1", "uniprot_id": [ { "id": "PP1RA_RAT", "url": "https://www.uniprot.org/uniprot/O55000", "type": "external" } ], "mass": 92828.0, "length": 872, "protein_name": "Serine/threonine-protein phosphatase 1 regulatory subunit 10", "gene_name": "Ppp1r10", "organism": "Rat", "refseq_name": "serine/threonine-protein phosphatase 1 regulatory subunit 10", "refseq_ac": [ { "id": "NP_075240", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075240", "type": "external" } ], "gene_names_uniprotkb": "Ppp1r10; Pnuts", "gene_names_refseq": "Fb19; Pnuts; Ppp1r10", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 1 regulatory subunit 10; Phosphatase 1 nuclear targeting subunit", "protein_names_refseq": "MHC class I region proline-rich protein CAT53; phosphatase 1 nuclear targeting subunit; putative protein phosphatase 1 nuclear targeting subunit; serine/threonine-protein phosphatase 1 regulatory subunit 10", "tax_id": 10116, "disease": "", "pathway": " (rno:65045)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12574161;15060004;22673903;24591642;35244724;9461602", "class_list": "", "function": "PNUTS has a role in protein kinase A-regulated targeting of PP1 to specific RNA-associated complexes in the nucleus, [RefSeq, PubMed]; Substrate-recognition component of the PNUTS-PP1 protein phosphatase complex, a protein phosphatase 1 (PP1) complex that promotes RNA polymerase II transcription pause-release, allowing transcription elongation (By similarity). Promoter-proximal pausing by RNA polymerase II is a transcription halt following transcription initiation but prior to elongation, which acts as a checkpoint to control that transcripts are favorably configured for transcriptional elongation (By similarity). The PNUTS-PP1 complex mediates the release of RNA polymerase II from promoter-proximal region of genes by catalyzing dephosphorylation of proteins involved in transcription, such as AFF4, CDK9, MEPCE, INTS12, NCBP1, POLR2M/GDOWN1 and SUPT6H (By similarity). The PNUTS-PP1 complex also regulates RNA polymerase II transcription termination by mediating dephosphorylation of SUPT5H in termination zones downstream of poly(A) sites, thereby promoting deceleration of RNA polymerase II transcription (By similarity). PNUTS-PP1 complex is also involved in the response to replication stress by mediating dephosphorylation of POLR2A at 'Ser-5' of the CTD, promoting RNA polymerase II degradation (By similarity). The PNUTS-PP1 complex also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (By similarity). PNUTS-PP1 complex mediates dephosphorylation of MYC, promoting MYC stability by preventing MYC ubiquitination by the SCF(FBXW7) complex (By similarity). In addition to acts as a substrate-recognition component, PPP1R10/PNUTS also acts as a nuclear targeting subunit for the PNUTS-PP1 complex (By similarity). In some context, PPP1R10/PNUTS also acts as an inhibitor of protein phosphatase 1 (PP1) activity by preventing access to substrates (PubMed:12574161, PubMed:24591642, PubMed:9461602)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6MG09", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0019888 protein phosphatase regulator activity;GO:0008157 protein phosphatase 1 binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0000785 chromatin;GO:0072357 PTW/PP1 phosphatase complex;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0050821 protein stabilization;GO:0010667 negative regulation of cardiac muscle cell apoptotic process;GO:2000806 positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled;GO:0001111 RNA polymerase II promoter clearance;GO:0032968 positive regulation of transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O55000-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01150-1", "uniprot_id": [ { "id": "TRH_RAT", "url": "https://www.uniprot.org/uniprot/P01150", "type": "external" } ], "mass": 29284.0, "length": 255, "protein_name": "Pro-thyrotropin-releasing hormone", "gene_name": "Trh", "organism": "Rat", "refseq_name": "thyrotropin releasing hormone preproprotein", "refseq_ac": [ { "id": "NP_037178", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037178", "type": "external" } ], "gene_names_uniprotkb": "Trh", "gene_names_refseq": "Pro-TRH; THR; TRH01; Trf; Trh", "protein_names_uniprotkb": "Pro-thyrotropin-releasing hormone; Pro-TRH; Prothyroliberin; Protirelin; TRF; TSH-releasing factor; Thyroliberin; Thyrotropin-releasing factor", "protein_names_refseq": "TSH-releasing factor; pro-thyrotropin-releasing hormone; prothyroliberin; protirelin; thyrotropin releasing hormone preproprotein; thyrotropin-releasing factor", "tax_id": 10116, "disease": "hypertension (Disease Ontology:DOID:10763); hypothyroidism (Disease Ontology:DOID:1459)", "pathway": " (rno:25569); (R-RNO-375276); (R-RNO-416476)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "2119297;2497670;26626087;2903153;29057835;3079917;32227104;32980456;34043769", "class_list": "", "function": "Differential activating effects of thyrotropin-releasing hormone and its analog taltirelin on motor output to the tongue musculature in vivo., [RefSeq, PubMed]; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems., [UniProtKB]; Intrauterine Zn deficiency favors thyrotropin-releasing hormone-increasing effects on thyrotropin serum levels and induces subclinical hypothyroidism in weaned rats. Publication Status: Online-Only, [RefSeq, PubMed]; Sex Dimorphic Changes in Trh Gene Methylation and Thyroid-Axis Response to Energy Demands in Maternally Separated Rats., [RefSeq, PubMed]; TRH in the nucleus accumbens acts downstream to alpha-MSH to decrease food intake in rats., [RefSeq, PubMed]; This gene encodes a member of the thyrotropin-releasing hormone family. Cleavage of the encoded proprotein releases mature thyrotropin-releasing hormone, which is a tripeptide hypothalamic regulatory hormone. The rat proprotein contains five thyrotropin-releasing hormone tripeptides. Thyrotropin-releasing hormone is involved in the regulation and release of thyroid-stimulating hormone, as well as prolactin, and may be involved in cardiac function in heart failure. Disruption of this gene is associated with hypothyroidism, elevated thyroid-stimulating hormone levels, and hyperglycemia. [provided by RefSeq, May 2013]., [RefSeq]; We found that dehydration induced anorexia rats showed increased number of thyrotropin-releasing hormone (TRH) cells in caudal paraventricular hypothalamic nucleus, as well as a decreased percentage of TRH-expressing neurons that co-expressed monocarboxylate transporter-8 mRNA signal., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008437 thyrotropin-releasing hormone activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule", "go_biological_process": "GO:2000252 negative regulation of feeding behavior;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0032024 positive regulation of insulin secretion;GO:0045471 response to ethanol;GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P01150-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11248-1", "uniprot_id": [ { "id": "PRM2_RAT", "url": "https://www.uniprot.org/uniprot/P11248", "type": "external" } ], "mass": 13366.0, "length": 104, "protein_name": "Protamine-2", "gene_name": "Prm2", "organism": "Rat", "refseq_name": "protamine-2", "refseq_ac": [ { "id": "NP_037005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037005", "type": "external" } ], "gene_names_uniprotkb": "Prm2", "gene_names_refseq": "PROTA2; Prm2", "protein_names_uniprotkb": "Protamine-2; Sperm histone P2; Sperm protamine P2", "protein_names_refseq": "protamine-2; sperm histone P2; sperm protamine P2", "tax_id": 10116, "disease": "", "pathway": " (rno:25345)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22673903;2740236;8720108", "class_list": "", "function": "Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046870 cadmium ion binding;GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007286 spermatid development;GO:0030261 chromosome condensation;GO:0006997 nucleus organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P11248-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19527-1", "uniprot_id": [ { "id": "NFL_RAT", "url": "https://www.uniprot.org/uniprot/P19527", "type": "external" } ], "mass": 61335.0, "length": 542, "protein_name": "Neurofilament light polypeptide", "gene_name": "Nefl", "organism": "Rat", "refseq_name": "neurofilament light polypeptide", "refseq_ac": [ { "id": "NP_113971", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113971", "type": "external" } ], "gene_names_uniprotkb": "Nefl; Nf68; Nfl", "gene_names_refseq": "NF-L; NF68; Nefl; Nfl", "protein_names_uniprotkb": "Neurofilament light polypeptide; 68 kDa neurofilament protein; NF-L; Neurofilament triplet L protein", "protein_names_refseq": "68 kDa neurofilament protein; 68kDa neurofilament; neurofilament light polypeptide; neurofilament triplet L protein; neurofilament, light polypeptide", "tax_id": 10116, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); fatal familial insomnia (Disease Ontology:DOID:0050433); stroke (Disease Ontology:DOID:0051061); Charcot-Marie-Tooth disease dominant intermediate G (Disease Ontology:DOID:0080294); COVID-19 (Disease Ontology:DOID:0080600); mild cognitive impairment (Disease Ontology:DOID:0080832); Charcot-Marie-Tooth disease type 1F (Disease Ontology:DOID:0110149); Charcot-Marie-Tooth disease type 2E (Disease Ontology:DOID:0110165); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); Alzheimer's disease (Disease Ontology:DOID:10652); sciatic neuropathy (Disease Ontology:DOID:11446); Creutzfeldt-Jakob disease (Disease Ontology:DOID:11949); Lewy body dementia (Disease Ontology:DOID:12217); Sjogren's syndrome (Disease Ontology:DOID:12894); Parkinson's disease (Disease Ontology:DOID:14330); hypothyroidism (Disease Ontology:DOID:1459); depressive disorder (Disease Ontology:DOID:1596); transient cerebral ischemia (Disease Ontology:DOID:224); multiple sclerosis (Disease Ontology:DOID:2377); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); invasive ductal carcinoma (Disease Ontology:DOID:3008); demyelinating disease (Disease Ontology:DOID:3213); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); syphilis (Disease Ontology:DOID:4166); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); acute disseminated encephalomyelitis (Disease Ontology:DOID:639); progressive multifocal leukoencephalopathy (Disease Ontology:DOID:643); vascular dementia (Disease Ontology:DOID:8725); neuromyelitis optica (Disease Ontology:DOID:8869); frontotemporal dementia (Disease Ontology:DOID:9255)", "pathway": " (rno:83613); (R-RNO-438066); (R-RNO-5673001)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "10428477;2162386;22673903;2516804;32574643;33727100;38843836;3925999;7745611;8344946;8702840;8769885;9388258;9521713", "class_list": "", "function": "Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity)., [UniProtKB, UniProtKB]; Temporal profile and utility of serum neurofilament light in a rat model of mild traumatic brain injury., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 2, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 30, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q63367", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0019904 protein domain specific binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030424 axon;GO:0030426 growth cone;GO:0031594 neuromuscular junction", "go_biological_process": "GO:0008090 retrograde axonal transport;GO:0045110 intermediate filament bundle assembly;GO:0021510 spinal cord development;GO:0050885 neuromuscular process controlling balance;GO:0021766 hippocampus development", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P19527-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20171-1", "uniprot_id": [ { "id": "RASH_RAT", "url": "https://www.uniprot.org/uniprot/P20171", "type": "external" } ], "mass": 21298.0, "length": 189, "protein_name": "GTPase HRas", "gene_name": "Hras", "organism": "Rat", "refseq_name": "GTPase HRas", "refseq_ac": [ { "id": "NP_001091711", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091711", "type": "external" } ], "gene_names_uniprotkb": "Hras; Hras1", "gene_names_refseq": "HRAS1; Hras; c-H-ras", "protein_names_uniprotkb": "GTPase HRas; 3.6.5.2; H-Ras-1; Transforming protein p21; c-H-ras; p21ras", "protein_names_refseq": "GTPase HRas; H-Ras-1; Harvey ras1 protein; Harvey rat sarcoma viral (v-Ha-ras) oncogene homolog; Harvey rat sarcoma virus oncogene; p21ras; transforming protein p21", "tax_id": 10116, "disease": "", "pathway": " (rno:293621); (R-RNO-1169092); (R-RNO-1250347); (R-RNO-1433557); (R-RNO-171007); (R-RNO-179812); (R-RNO-180336); (R-RNO-186763); (R-RNO-1963640); (R-RNO-210993); (R-RNO-2179392); (R-RNO-2424491); (R-RNO-2871796); (R-RNO-375165); (R-RNO-3928662); (R-RNO-5218921); (R-RNO-5621575); (R-RNO-5654688); (R-RNO-5654693); (R-RNO-5654699); (R-RNO-5654700); (R-RNO-5654704); (R-RNO-5654706); (R-RNO-5654712); (R-RNO-5654719); (R-RNO-5658442); (R-RNO-5673000); (R-RNO-5673001); (R-RNO-5674135); (R-RNO-5675221); (R-RNO-8849471); (R-RNO-8851805); (R-RNO-9607240); (R-RNO-9634635); (R-RNO-9648002)", "pathway_count": 35, "publication_count": 10, "publication_id_list": "11179219;19319189;19878719;26035971;26568031;27125250;28193718;3023901;3027702;3290900", "class_list": "", "function": "H-ras isoform mediates protection against pressure overload-induced cardiac dysfunction in part through activation of AKT/PI3K signaling pathway., [RefSeq, PubMed]; It has been found that NaBut reduces proliferation rate of ERasBcl (E1A, cHa-ras and bcl-2 ) cells significantly weaker than of ERas transformed cells, [RefSeq, PubMed]; Phenotypic Screening Identifies Protein Synthesis Inhibitors as H-Ras-Nanocluster-Increasing Tumor Growth Inducers., [RefSeq, PubMed]; Signal transducer in the Ras-MAPK signaling pathway that regulates cell proliferation and survival (By similarity). Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Recognized by LZTR1 that mediates its ubiquitination by a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex (By similarity)., [UniProtKB, UniProtKB]; Together, these results suggest a novel mechanism regulating PATZ1 expression based on the upregulation of miR-29b expression induced by Ras oncogene. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4KLL6;Q5RJJ8", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.4.26.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.26.1", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "2.5.1.58", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.58", "type": "external" }, { "id": "2.5.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.59", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "2.7.1.91", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.91", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.1.1.100", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.100", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0044877 protein-containing complex binding;GO:0043495 protein-membrane adaptor activity;GO:0019003 GDP binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000164 protein phosphatase type 1 complex;GO:0000139 Golgi membrane;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0046579 positive regulation of Ras protein signal transduction;GO:0001889 liver development;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006897 endocytosis;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P20171-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P37805-1", "uniprot_id": [ { "id": "TAGL3_RAT", "url": "https://www.uniprot.org/uniprot/P37805", "type": "external" } ], "mass": 22501.0, "length": 199, "protein_name": "Transgelin-3", "gene_name": "Tagln3", "organism": "Rat", "refseq_name": "transgelin-3", "refseq_ac": [ { "id": "NP_001030313", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030313", "type": "external" } ], "gene_names_uniprotkb": "Tagln3; Np25", "gene_names_refseq": "Np22; Np25; Tagln3", "protein_names_uniprotkb": "Transgelin-3; NP22; Neuronal protein 22; Neuronal protein NP25", "protein_names_refseq": "neuronal protein 22; neuronal protein Np25; transgelin-3", "tax_id": 10116, "disease": "", "pathway": " (rno:63837)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16542643;22673903;8015377", "class_list": "", "function": "NP22 may play a role in mediating the molecular events governing development of the neuronal architecture. Furthermore, its sustained expression in postnatal brain implies a function in the maintenance of neuronal morphology., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q09025;Q8VHH3", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding", "go_cellular_component": "GO:0005634 nucleus;GO:0015629 actin cytoskeleton;GO:0045202 synapse", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007015 actin filament organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P37805-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50232-1", "uniprot_id": [ { "id": "SYT4_RAT", "url": "https://www.uniprot.org/uniprot/P50232", "type": "external" } ], "mass": 47685.0, "length": 425, "protein_name": "Synaptotagmin-4", "gene_name": "Syt4", "organism": "Rat", "refseq_name": "synaptotagmin-4", "refseq_ac": [ { "id": "NP_113881", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113881", "type": "external" } ], "gene_names_uniprotkb": "Syt4", "gene_names_refseq": "Syt4", "protein_names_uniprotkb": "Synaptotagmin-4; Synaptotagmin IV; SytIV", "protein_names_refseq": "synaptotagmin IV; synaptotagmin-4; sytIV", "tax_id": 10116, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:64440)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "18046461;22673903;29166604;30021165;7892240;7993622;9162066", "class_list": "", "function": "Neuronal activity increased dense core vesicle capture via JNK-dependent phosphorylation of the S135 site of Synaptotagmin-4, [RefSeq, PubMed]; Synaptotagmin family member which does not bind Ca(2+) (PubMed:7993622). Involved in neuronal dense core vesicles (DCVs) mobility through its interaction with KIF1A. Upon increased neuronal activity, phosphorylation by MAPK8/JNK1 destabilizes the interaction with KIF1A and captures DCVs to synapses (PubMed:29166604). Plays a role in dendrite formation by melanocytes (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0005509 calcium ion binding;GO:0019905 syntaxin binding;GO:0005544 calcium-dependent phospholipid binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098992 neuronal dense core vesicle;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:2000301 negative regulation of synaptic vesicle exocytosis;GO:1903861 positive regulation of dendrite extension;GO:0050709 negative regulation of protein secretion;GO:0007613 memory;GO:0030100 regulation of endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P50232-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62963-1", "uniprot_id": [ { "id": "PROF1_RAT", "url": "https://www.uniprot.org/uniprot/P62963", "type": "external" } ], "mass": 14957.0, "length": 140, "protein_name": "Profilin-1", "gene_name": "Pfn1", "organism": "Rat", "refseq_name": "profilin-1", "refseq_ac": [ { "id": "NP_071956", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071956", "type": "external" } ], "gene_names_uniprotkb": "Pfn1", "gene_names_refseq": "Pfn1", "protein_names_uniprotkb": "Profilin-1; Profilin I", "protein_names_refseq": "profilin I; profilin-1", "tax_id": 10116, "disease": "amyotrophic lateral sclerosis type 18 (Disease Ontology:DOID:0060209); pancreatic cancer (Disease Ontology:DOID:1793); membranoproliferative glomerulonephritis (Disease Ontology:DOID:2920)", "pathway": " (rno:64303); (R-RNO-4086400); (R-RNO-5663220)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "22673903;27185630;29238726;30392913;31599437;36989867;8651905", "class_list": "", "function": "Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Collectively, these data suggest that PFN-1 may play an important role in AGEs-induced hypertrophy and apoptosis in H9c2 cells., [RefSeq, PubMed]; Distribution analysis of profilin isoforms at transcript resolution with mRNA-sequence and secondary structure in various organs of Rattus norvegicus has been reported., [RefSeq, PubMed]; Mechanism of action of Profilin-1 and Fibulin-3 in vascular remodeling in hypertensive rats., [RefSeq, PubMed]; Profilin binds to activated PKCepsilon and facilitates PKCepsilon activation by accelerating ATP supply to PKCepsilon. Erratum:[Biochem Biophys Res Commun. 2019 May 21;513(1):291. doi: 10.1016/j.bbrc.2019.03.023. PMID: 30952433], [RefSeq, PubMed]; Role of profilin-1 in vasculopathy induced by advanced glycation end products (AGEs)., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P10924", "ec_number_list": [], "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0003779 actin binding;GO:0003785 actin monomer binding;GO:0005102 signaling receptor binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005938 cell cortex", "go_biological_process": "GO:0098885 modification of postsynaptic actin cytoskeleton;GO:0032233 positive regulation of actin filament bundle assembly;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P62963-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63043-1", "uniprot_id": [ { "id": "STMN4_RAT", "url": "https://www.uniprot.org/uniprot/P63043", "type": "external" } ], "mass": 22087.0, "length": 189, "protein_name": "Stathmin-4", "gene_name": "Stmn4", "organism": "Rat", "refseq_name": "stathmin-4 isoform c", "refseq_ac": [ { "id": "NP_001257785", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257785", "type": "external" } ], "gene_names_uniprotkb": "Stmn4", "gene_names_refseq": "Lagl; Rb3; Stmn4", "protein_names_uniprotkb": "Stathmin-4; RB3; Stathmin-like protein B3", "protein_names_refseq": "stathmin-4 isoform c; stathmin-like 4; stathmin-like protein B3; stathmin-like-protein RB3", "tax_id": 10116, "disease": "", "pathway": " (rno:79423)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12111843;15014504;15039434;16256088;22673903;9342231", "class_list": "", "function": "Exhibits microtubule-destabilizing activity., [UniProtKB, PubMed, PubMed, PubMed]; RB3 is the unique response protein in the stathmin-related proteins following optic nerve axotomy and the induced RB3 may play a critical role in the CNTF-induced response on the axotomized retinal ganglion cells, [RefSeq, PubMed]; Regulatory role of the unique N-terminal domain of RB3 in microtubule dynamics would contribute to the physiological regulation of neuronal morphogenesis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35414;O35415;O35416", "ec_number_list": [], "go_molecular_function": "GO:0015631 tubulin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0030426 growth cone;GO:0043005 neuron projection", "go_biological_process": "GO:0031110 regulation of microtubule polymerization or depolymerization;GO:0031175 neuron projection development;GO:0007019 microtubule depolymerization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P63043-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97610-1", "uniprot_id": [ { "id": "SYT12_RAT", "url": "https://www.uniprot.org/uniprot/P97610", "type": "external" } ], "mass": 46608.0, "length": 421, "protein_name": "Synaptotagmin-12", "gene_name": "Syt12", "organism": "Rat", "refseq_name": "synaptotagmin-12", "refseq_ac": [ { "id": "NP_620190", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620190", "type": "external" } ], "gene_names_uniprotkb": "Syt12; Srg1; Sytr1", "gene_names_refseq": "Srg1; Syt12", "protein_names_uniprotkb": "Synaptotagmin-12; Srg1; Synaptotagmin XII; Synaptotagmin-related gene 1 protein; SytXII", "protein_names_refseq": "synaptotagmin XII; synaptotagmin-12; synaptotagmin-related gene 1 protein; sytXII", "tax_id": 10116, "disease": "", "pathway": " (rno:191595)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17190793;22673903;8987811", "class_list": "", "function": "Synaptic vesicle phosphoprotein that enhances spontaneous neurotransmitter release but does not effect induced neurotransmitter release (PubMed:17190793). Unlike other synaptotagmins, it does not bind Ca(2+) or phospholipids (PubMed:17190793). Essential for mossy-fiber long-term potentiation in the hippocampus (By similarity)., [UniProtKB, UniProtKB, PubMed]; These data suggest that spontaneous synaptic-vesicle exocytosis is selectively modulated by a Ca(2+)-independent synaptotagmin isoform, synaptotagmin-12, which is controlled by cyclic AMP-dependent phosphorylation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005544 calcium-dependent phospholipid binding;GO:0000149 SNARE binding;GO:0061891 calcium ion sensor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030672 synaptic vesicle membrane;GO:0008021 synaptic vesicle;GO:0070382 exocytic vesicle;GO:0098793 presynapse", "go_biological_process": "GO:0046928 regulation of neurotransmitter secretion;GO:0016192 vesicle-mediated transport;GO:0060291 long-term synaptic potentiation;GO:0017158 regulation of calcium ion-dependent exocytosis;GO:0048792 spontaneous exocytosis of neurotransmitter", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P97610-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02563-1", "uniprot_id": [ { "id": "SV2A_RAT", "url": "https://www.uniprot.org/uniprot/Q02563", "type": "external" } ], "mass": 82661.0, "length": 742, "protein_name": "Synaptic vesicle glycoprotein 2A", "gene_name": "Sv2a", "organism": "Rat", "refseq_name": "synaptic vesicle glycoprotein 2A", "refseq_ac": [ { "id": "NP_476558", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476558", "type": "external" } ], "gene_names_uniprotkb": "Sv2a; Sv2", "gene_names_refseq": "Sv2a; Sv2", "protein_names_uniprotkb": "Synaptic vesicle glycoprotein 2A; Synaptic vesicle protein 2A; Synaptic vesicle protein 2", "protein_names_refseq": "synaptic vesicle glycoprotein 2A; synaptic vesicle protein 2A; synaptic vesicle protein 2; synaptic vesicle transmembrane transporter (SV2) RNA", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy (Disease Ontology:DOID:0112202); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (rno:117559)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "10455054;10625067;10747945;1355409;1426240;1519064;15210974;15866046;16306227;16543415;18815274;19476346;19650874;21483489;21632541;22673903;24090084;29649119;30905653;32407277;32538280;34435329;38801174;38843836;8910372", "class_list": "", "function": "(Microbial infection) Receptor for C.botulinum neurotoxin type A (BoNT/A, botA); the toxin binds via extracellular loop 4 (PubMed:16543415). Restores uptake of BoNT/A in mouse cells that are deleted for SV2 receptor (PubMed:16543415, PubMed:18815274). Glycosylation of Asn-573 is not essential for receptor activity, but enhances uptake (PubMed:18815274, PubMed:19650874). Also serves as a receptor for the closely related C.botulinum neurotoxin type A2; glycosylation is not essential but enhances the interaction (PubMed:29649119)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; (Microbial infection) Receptor for C.botulinum neurotoxin type E (BoNT/E); the toxin probably binds via extracellular loop 4 and requires glycosylation of Asn-573 (PubMed:18815274, PubMed:19650874). Restores uptake of BoNT/E in mouse cells that are deleted for SV2 receptor (PubMed:18815274)., [UniProtKB, PubMed, PubMed]; (Microbial infection) Receptor for C.botulinum neurotoxin type F (BoNT/F) (PubMed:19476346, PubMed:19650874). Binding requires glycosylation of Asn-573 (PubMed:19476346)., [UniProtKB, PubMed, PubMed]; Brivaracetam Prevents the Over-expression of Synaptic Vesicle Protein 2A and Rescues the Deficits of Hippocampal Long-term Potentiation In Vivo in Chronic Temporal Lobe Epilepsy Rats., [RefSeq, PubMed]; Differential expression of SV2A in hippocampal glutamatergic and GABAergic terminals during postnatal development., [RefSeq, PubMed]; In vivo imaging of synaptic SV2A protein density in healthy and striatal-lesioned rats with [11C]UCB-J PET., [RefSeq, PubMed]; Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles., [UniProtKB, UniProtKB, UniProtKB]; Possible receptor for C.botulinum neurotoxin type D (BoNT/D, botD); BoNT/D does not bind to extracellular loop 4 as do BoNT/A and BoNT/E, nor to loop 1 or loop 3 (PubMed:21483489). Another group does not find a convincing interaction with SV2 (PubMed:21632541)., [UniProtKB, PubMed, PubMed]; Reductions in Synaptic Vesicle Glycoprotein 2 Isoforms in the Cortex and Hippocampus in a Rat Model of Traumatic Brain Injury., [RefSeq, PubMed]; Synaptic vesicle protein 2A mitigates parthanatos via apoptosis-inducing factor in a rat model of pharmacoresistant epilepsy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 6, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q58DZ8", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005783 endoplasmic reticulum;GO:0005911 cell-cell junction;GO:0030425 dendrite", "go_biological_process": "GO:0098828 modulation of inhibitory postsynaptic potential;GO:0006874 intracellular calcium ion homeostasis;GO:0035418 protein localization to synapse;GO:0014052 regulation of gamma-aminobutyric acid secretion;GO:0016082 synaptic vesicle priming", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "Q02563-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.1100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V891-1", "uniprot_id": [ { "id": "POC5_RAT", "url": "https://www.uniprot.org/uniprot/Q4V891", "type": "external" } ], "mass": 60995.0, "length": 558, "protein_name": "Centrosomal protein POC5", "gene_name": "Poc5", "organism": "Rat", "refseq_name": "centrosomal protein POC5", "refseq_ac": [ { "id": "NP_001020818", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020818", "type": "external" } ], "gene_names_uniprotkb": "Poc5", "gene_names_refseq": "Poc5; RGD1310597", "protein_names_uniprotkb": "Centrosomal protein POC5; Protein of centriole 5", "protein_names_refseq": "POC5 centriolar protein homolog; centrosomal protein POC5; protein of centriole 5; proteome of centriole 5", "tax_id": 10116, "disease": "", "pathway": " (rno:294667)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "Essential for the assembly of the distal half of centrioles, required for centriole elongation. Acts as a negative regulator of centriole elongation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005814 centriole;GO:0032391 photoreceptor connecting cilium", "go_biological_process": "GO:1903723 negative regulation of centriole elongation;GO:0042462 eye photoreceptor cell development;GO:0061511 centriole elongation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4V891-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q58DZ9-1", "uniprot_id": [ { "id": "SYNG1_RAT", "url": "https://www.uniprot.org/uniprot/Q58DZ9", "type": "external" } ], "mass": 28384.0, "length": 258, "protein_name": "Synapse differentiation-inducing gene protein 1", "gene_name": "Syndig1", "organism": "Rat", "refseq_name": "synapse differentiation-inducing gene protein 1", "refseq_ac": [ { "id": "NP_001020191", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020191", "type": "external" } ], "gene_names_uniprotkb": "Syndig1; Tmem90b", "gene_names_refseq": "DSPC2; RGD1310753; Syndig1; Tmem90b", "protein_names_uniprotkb": "Synapse differentiation-inducing gene protein 1; DSPC2; Dispanin subfamily C member 2; SynDIG1; Transmembrane protein 90B", "protein_names_refseq": "dispanin subfamily C member 2; synapse differentiation-inducing gene protein 1; transmembrane protein 90B", "tax_id": 10116, "disease": "", "pathway": " (rno:362235)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "20152115;21878521;22363774;22673903;23785483;26660156", "class_list": "", "function": "An interesting aspect of SynDIG1 is that its distribution at excitatory synapses is regulated by activity, suggesting that SynDIG1 might also play a role in synaptic plasticity. Review article, [RefSeq, PubMed]; May regulate AMPA receptor content at nascent synapses, and have a role in postsynaptic development and maturation., [UniProtKB, PubMed]; Results describe SynDIG1 as an activity-regulated transmembrane protein that regulates AMPA receptor content and excitatory synapse development., [RefSeq, PubMed]; SynDIG1 is not a typical auxiliary subunit to AMPA receptors, but instead is a protein critical to excitatory synaptogenesis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0035254 glutamate receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0043197 dendritic spine;GO:0043198 dendritic shaft", "go_biological_process": "GO:0097091 synaptic vesicle clustering;GO:0006886 intracellular protein transport;GO:0051965 positive regulation of synapse assembly;GO:0150052 regulation of postsynapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q58DZ9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XHZ0-1", "uniprot_id": [ { "id": "TRAP1_RAT", "url": "https://www.uniprot.org/uniprot/Q5XHZ0", "type": "external" } ], "mass": 80461.0, "length": 706, "protein_name": "Heat shock protein 75 kDa, mitochondrial", "gene_name": "Trap1", "organism": "Rat", "refseq_name": "heat shock protein 75 kDa, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001034090", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034090", "type": "external" } ], "gene_names_uniprotkb": "Trap1; Hsp75; Hspc5", "gene_names_refseq": "Trap1", "protein_names_uniprotkb": "Heat shock protein 75 kDa, mitochondrial; HSP 75; TNFR-associated protein 1; TRAP-1; Tumor necrosis factor type 1 receptor-associated protein", "protein_names_refseq": "HSP 75; TNFR-associated protein 1; TRAP-1; heat shock protein 75 kDa, mitochondrial precursor; heat shock protein 75 kDa, mitochondrial; tumor necrosis factor type 1 receptor-associated protein", "tax_id": 10116, "disease": "", "pathway": " (rno:287069); (R-RNO-71403)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "16641100;27592455;32215175", "class_list": "", "function": "Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Tumor Necrosis Factor Receptor-Associated Protein 1 Protects against Mitochondrial Injury by Preventing High Glucose-Induced mPTP Opening in Diabetes. Publication Status: Online-Only, [RefSeq, PubMed]; Tumor necrosis factor receptor-associated protein 1 protects cardiomyocytes from hypoxia at least partly via potentiation of energy generation, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:1903751 negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide;GO:0006457 protein folding;GO:0009386 translational attenuation;GO:1901856 negative regulation of cellular respiration", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5XHZ0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63564-1", "uniprot_id": [ { "id": "SV2B_RAT", "url": "https://www.uniprot.org/uniprot/Q63564", "type": "external" } ], "mass": 77502.0, "length": 683, "protein_name": "Synaptic vesicle glycoprotein 2B", "gene_name": "Sv2b", "organism": "Rat", "refseq_name": "synaptic vesicle glycoprotein 2B", "refseq_ac": [ { "id": "NP_476555", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476555", "type": "external" } ], "gene_names_uniprotkb": "Sv2b; Sv2bb", "gene_names_refseq": "Sv2b", "protein_names_uniprotkb": "Synaptic vesicle glycoprotein 2B; Synaptic vesicle protein 2B", "protein_names_refseq": "synaptic vesicle glycoprotein 2B; synaptic vesicle protein 2B", "tax_id": 10116, "disease": "", "pathway": " (rno:117556)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "10.1039/D0MO00044B;10625067;10747945;11741278;12754292;15866046;16306227;16543415;18815274;19476346;19650874;21483489;21632541;22673903;23167466;29649119;34106099;34435329;7681585;9648885;9801366", "class_list": "", "function": "(Microbial infection) Possible receptor for C.botulinum neurotoxin type D (BoNT/D, botD); BoNT/D does not bind to extracellular loop 4 as do BoNT/A and BoNT/E (PubMed:21483489). Another group does not find a convincing interaction with SV2 (PubMed:21632541)., [UniProtKB, PubMed, PubMed]; (Microbial infection) Receptor for C.botulinum neurotoxin type A (BoNT/A, botA); the toxin binds via extracellular loop 4 (PubMed:16543415). Restores uptake of BoNT/A in mouse and rat cells that are deleted for SV2 receptor (PubMed:16543415, PubMed:18815274). Glycosylation of SV2B is not essential for receptor activity, but enhances the interaction (PubMed:18815274, PubMed:19650874). Also serves as a receptor for the closely related C.botulinum neurotoxin type A2; glycosylation is not essential but enhances the interaction (PubMed:29649119)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; (Microbial infection) Receptor for C.botulinum neurotoxin type E (BoNT/E); the toxin probably binds via extracellular loop 4 (PubMed:18815274). Restores uptake of BoNT/E in mouse cells that are deleted for SV2 receptor (PubMed:18815274). Glycosylation of SV2B is not essential for receptor activity, but enhances the interaction (PubMed:19650874)., [UniProtKB, PubMed, PubMed]; (Microbial infection) Receptor for C.botulinum neurotoxin type F (BoNT/F); binding requires glycosylation of this protein (PubMed:19476346, PubMed:19650874)., [UniProtKB, PubMed, PubMed]; For the first time, synaptic vesicle protein (SV) 2b, an important transmembrane transporter of Ca2+-stimulated vesicle exocytosis, was identified as a differentially expressed molecule localized in fully differentiated odontoblasts and pre-odontoblasts., [RefSeq, PubMed]; Probably plays a role in the control of regulated secretion in neural and endocrine cells., [UniProtKB]; Reductions in Synaptic Vesicle Glycoprotein 2 Isoforms in the Cortex and Hippocampus in a Rat Model of Traumatic Brain Injury., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9577, "biomarker_type": "", "glycan_count": 5, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0043195 terminal bouton;GO:0001669 acrosomal vesicle;GO:0030672 synaptic vesicle membrane;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0007268 chemical synaptic transmission;GO:0001504 neurotransmitter uptake;GO:0099509 regulation of presynaptic cytosolic calcium ion concentration;GO:2000300 regulation of synaptic vesicle exocytosis;GO:0006836 neurotransmitter transport", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q63564-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CJ52-1", "uniprot_id": [ { "id": "PROM2_RAT", "url": "https://www.uniprot.org/uniprot/Q8CJ52", "type": "external" } ], "mass": 92841.0, "length": 834, "protein_name": "Prominin-2", "gene_name": "Prom2", "organism": "Rat", "refseq_name": "prominin-2 precursor", "refseq_ac": [ { "id": "NP_620212", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620212", "type": "external" } ], "gene_names_uniprotkb": "Prom2; Proml2; Trprp", "gene_names_refseq": "Prom-rp; Prom2; Promrp; Trprp", "protein_names_uniprotkb": "Prominin-2; PROM-2; Prominin-like protein 2; Testosterone-regulated prominin-related protein; rPROML2", "protein_names_refseq": "PROM-2; prominin-2 precursor; prominin-like protein 2; prominin-related protein; rPROML2; testosterone-regulated prominin-related protein", "tax_id": 10116, "disease": "retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (rno:192211)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12446606;12514187;12832703;17109118;22673903;29113580", "class_list": "", "function": "Results argue that PROML2 is a novel proapoptotic membrane protein; its down-regulation may associate with aggressive phenotype of prostate cancer cells, [RefSeq, PubMed]; Study shows that prominin-2 prevents the formation of caveolae in normal and ovarian hyperstimulated pregnancy., [RefSeq, PubMed]; These data show that all the characteristics of prominin-1 are shared by prominin-2, which is in agreement with a possible redundancy in their role as potential organizers of plasma membrane protrusions., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8R4B6", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0015485 cholesterol binding;GO:0008083 growth factor activity", "go_cellular_component": "GO:0044393 microspike;GO:0005635 nuclear envelope;GO:0005886 plasma membrane;GO:0005929 cilium;GO:0009986 cell surface", "go_biological_process": "GO:0048550 negative regulation of pinocytosis;GO:0001934 positive regulation of protein phosphorylation;GO:0032528 microvillus organization;GO:0031346 positive regulation of cell projection organization;GO:2001287 negative regulation of caveolin-mediated endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8CJ52-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63149-1", "uniprot_id": [ { "id": "UBE2B_RAT", "url": "https://www.uniprot.org/uniprot/P63149", "type": "external" } ], "mass": 17312.0, "length": 152, "protein_name": "Ubiquitin-conjugating enzyme E2 B", "gene_name": "Ube2b", "organism": "Rat", "refseq_name": "ubiquitin-conjugating enzyme E2 B", "refseq_ac": [ { "id": "NP_112400", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112400", "type": "external" } ], "gene_names_uniprotkb": "Ube2b; Rad6b", "gene_names_refseq": "HR6B; Ube2b", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 B; 2.3.2.23; E2 ubiquitin-conjugating enzyme B; HR6B; RAD6 homolog B; Ubiquitin carrier protein B; Ubiquitin-conjugating enzyme E2(14k); Ubiquitin-protein ligase B", "protein_names_refseq": "E2 ubiquitin-conjugating enzyme B; E2(14k); RAD6 homolog B; ubiquitin carrier protein B; ubiquitin conjugating enzyme; ubiquitin-conjugating enzyme E2 B; ubiquitin-conjugating enzyme E2(14k); ubiquitin-conjugating enzyme E2B (RAD6 homolog, S. cerevisiae); ubiquitin-conjugating enzyme E2B, RAD6 homology; ubiquitin-protein ligase B", "tax_id": 10116, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (rno:81816); (R-RNO-110314); (R-RNO-8866652); (R-RNO-8866654); (R-RNO-983168)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "1313008;15946855;31576007;34632937;8048511", "class_list": "", "function": "E2 ubiquitin-conjugating enzyme that accepts ubiquitin from the ubiquitin-activating enzyme E1 and transfers it to a E3 ubiquitin-protein ligase (PubMed:1313008). In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination (By similarity). Together with the E3 enzyme BRE1 (RNF20 and/or RNF40), plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1 (By similarity). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation (By similarity). May play a role in DNA repair (By similarity). Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164' (By similarity). In association with the E3 enzyme UBR4, is involved in N-end rule-dependent protein degradation (By similarity). May be involved in neurite outgrowth (PubMed:15946855)., [UniProtKB, PubMed, PubMed, UniProtKB]; Ube2b-dependent degradation of DNMT3a relieves a transcriptional brake on opiate-induced synaptic and behavioral plasticity., [RefSeq, PubMed]; Upregulation of ubiquitin conjugating enzyme E2B (Ube2b) ameliorates neuropathic pain by regulating Kcna2 (potassium voltage-gated channel subfamily A member 2) in primary afferent neurons., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P23567;Q9D0J6", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "6.2.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.64", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0031625 ubiquitin protein ligase binding;GO:0004842 ubiquitin-protein transferase activity;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0000785 chromatin;GO:0005657 replication fork", "go_biological_process": "GO:1901874 negative regulation of post-translational protein modification;GO:0001701 in utero embryonic development;GO:0006281 DNA repair;GO:0032869 cellular response to insulin stimulus;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P63149-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PTG8-1", "uniprot_id": [ { "id": "STK10_RAT", "url": "https://www.uniprot.org/uniprot/E9PTG8", "type": "external" } ], "mass": 111877.0, "length": 967, "protein_name": "Serine/threonine-protein kinase 10", "gene_name": "Stk10", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Stk10", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine/threonine-protein kinase 10; 2.7.11.1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-6798695); (R-RNO-8980692); (R-RNO-9013026); (R-RNO-9013106)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3ZUC0", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.4.21.73", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.73", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "1.14.19.17", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.17", "type": "external" }, { "id": "5.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.-", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.3.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.20", "type": "external" }, { "id": "2.3.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.76", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0046777 protein autophosphorylation;GO:0071593 lymphocyte aggregation;GO:2000401 regulation of lymphocyte migration", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9PTG8-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09527-1", "uniprot_id": [ { "id": "RAB7A_RAT", "url": "https://www.uniprot.org/uniprot/P09527", "type": "external" } ], "mass": 23504.0, "length": 207, "protein_name": "Ras-related protein Rab-7a", "gene_name": "Rab7a", "organism": "Rat", "refseq_name": "ras-related protein Rab-7a", "refseq_ac": [ { "id": "NP_076440", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076440", "type": "external" } ], "gene_names_uniprotkb": "Rab7a; Rab7", "gene_names_refseq": "Rab7a; Rab7", "protein_names_uniprotkb": "Ras-related protein Rab-7a; 3.6.5.2; Ras-related protein BRL-RAS; Ras-related protein p23", "protein_names_refseq": "RAB7, member RAS oncogene family; ras-related protein BRL-RAS; ras-related protein Rab-7a; ras-related protein p23", "tax_id": 10116, "disease": "Charcot-Marie-Tooth disease type 2 (Disease Ontology:DOID:0050539); Charcot-Marie-Tooth disease type 2B (Disease Ontology:DOID:0110159); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:29448); (R-RNO-2132295); (R-RNO-6798695); (R-RNO-8854214); (R-RNO-8873719); (R-RNO-8876198); (R-RNO-9013149); (R-RNO-9013404); (R-RNO-9013406); (R-RNO-9013407); (R-RNO-9013408); (R-RNO-9013423); (R-RNO-9035034)", "pathway_count": 13, "publication_count": 11, "publication_id_list": "15186776;15978772;16040606;16306406;18756270;22673903;3057452;30721447;35474277;36592695;37820423", "class_list": "", "function": "Dynein Is Required for Rab7-Dependent Endosome Maturation, Retrograde Dendritic Transport, and Degradation., [RefSeq, PubMed]; Research of STEAP3 interaction with Rab7A and RACK1 to modulate the MAPK and JAK/STAT signaling in Osteoarthritis., [RefSeq, PubMed]; The functions of RAB18 and RAB7 in lysosomal and autophagic activities may constitute an overlapping mechanism underlying Warburg micro syndrome and Charcot-Marie-Tooth Neuropathy Type 2B pathogenesis in the nervous system., [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. In its active state, RAB7A binds to a variety of effector proteins playing a key role in the regulation of endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Also plays a central role in growth-factor-mediated cell signaling, nutrient-transporter-mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By similarity). Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes (By similarity). Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and Mycobacteria (By similarity). Plays a role in the fusion of phagosomes with lysosomes (By similarity). In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts (PubMed:16040606). Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA (PubMed:16306406). Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation (By similarity). Involved in the ADRB2-stimulated lipolysis through lipophagy, a cytosolic lipase-independent autophagic pathway. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). Required for vesicular trafficking and cell surface expression of ACE2 (By similarity). May play a role in PRPH neuronal intermediate filament assembly (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]; Upregulation of RAB7 is related to neuronal pyroptosis after spinal cord injury in rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4AEF6", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.1.3.95", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.95", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.4.24.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.11", "type": "external" }, { "id": "3.4.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-", "type": "external" }, { "id": "3.4.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.2", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "1.16.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.1.-", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "1.6.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "5.6.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.3", "type": "external" }, { "id": "2.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.13", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0031267 small GTPase binding;GO:0019003 GDP binding", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005739 mitochondrion;GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0036466 synaptic vesicle recycling via endosome;GO:0090383 phagosome acidification;GO:0000045 autophagosome assembly;GO:0016042 lipid catabolic process;GO:0009617 response to bacterium", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P09527-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07825-1", "uniprot_id": [ { "id": "SYPH_RAT", "url": "https://www.uniprot.org/uniprot/P07825", "type": "external" } ], "mass": 33311.0, "length": 307, "protein_name": "Synaptophysin", "gene_name": "Syp", "organism": "Rat", "refseq_name": "synaptophysin", "refseq_ac": [ { "id": "NP_036796", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036796", "type": "external" } ], "gene_names_uniprotkb": "Syp", "gene_names_refseq": "Syp1; Syp", "protein_names_uniprotkb": "Synaptophysin; Major synaptic vesicle protein p38", "protein_names_refseq": "major synaptic vesicle protein p38; synaptophysin", "tax_id": 10116, "disease": "non-syndromic X-linked intellectual disability 96 (Disease Ontology:DOID:0112035); Alzheimer's disease (Disease Ontology:DOID:10652); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (rno:24804)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10.1039/D0MO00044B;11786535;1902431;19196426;19737347;22673903;23103755;26026271;29545098;30911273;31146894;3120152;3120313;3121632;3123215;34106099;35715368;37796476;38843836", "class_list": "", "function": "Cyclic glycine-proline administration normalizes high-fat diet-induced synaptophysin expression in obese rats., [RefSeq, PubMed]; Environmental enrichment initiated in adolescence restores the reduced expression of synaptophysin and GFAP in the hippocampus of chronically stressed rats in a sex-specific manner., [RefSeq, PubMed]; Paternal stress alters synaptic density and expression of GAP-43, GRIN1, M1 and SYP genes in the hippocampus and cortex of offspring of stress-induced male rats., [RefSeq, PubMed]; Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; SYP protein expression in the hippocampus in the chronic intermittent hypoxia rats. Publication Status: Online-Only, [RefSeq, PubMed]; The environmental enrichment protected against the effects of maternal separation as indicated by the lower anxiety levels and the reversal of spatial memory deficits compared to animals housed in standard conditions. These changes were associated with increased synaptophysin expression in the hippocampus., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 10, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q499R3", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0015485 cholesterol binding;GO:0044877 protein-containing complex binding;GO:0042169 SH2 domain binding", "go_cellular_component": "GO:0014069 postsynaptic density;GO:0016020 membrane;GO:0031594 neuromuscular junction;GO:0043195 terminal bouton;GO:0045178 basal part of cell", "go_biological_process": "GO:0048172 regulation of short-term neuronal synaptic plasticity;GO:0006897 endocytosis;GO:0048169 regulation of long-term neuronal synaptic plasticity;GO:0051260 protein homooligomerization;GO:1904645 response to amyloid-beta", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "P07825-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99041-1", "uniprot_id": [ { "id": "TGM4_RAT", "url": "https://www.uniprot.org/uniprot/Q99041", "type": "external" } ], "mass": 75587.0, "length": 667, "protein_name": "Protein-glutamine gamma-glutamyltransferase 4", "gene_name": "Tgm4", "organism": "Rat", "refseq_name": "protein-glutamine gamma-glutamyltransferase 4", "refseq_ac": [ { "id": "NP_073204", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073204", "type": "external" } ], "gene_names_uniprotkb": "Tgm4; Dp1", "gene_names_refseq": "Dp1; Tgm4", "protein_names_uniprotkb": "Protein-glutamine gamma-glutamyltransferase 4; 2.3.2.13; DP1; Dorsal prostate transglutaminase; Dorsal protein 1; TGase-4; Transglutaminase-4", "protein_names_refseq": "TGase-4; dorsal prostate transglutaminase; dorsal protein 1; glutamine gamma-glutamyltransferase 4; protein-glutamine gamma-glutamyltransferase 4; transglutaminase 4 (prostate)", "tax_id": 10116, "disease": "", "pathway": " (rno:64679)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "1352290;1676601;3309953;6149619;7191854;8910321", "class_list": "", "function": "Associated with the mammalian reproductive process. Plays an important role in the formation of the seminal coagulum through the cross-linking of specific proteins present in the seminal plasma. Transglutaminase is also required to stabilize the copulatory plug., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q6NYB5", "ec_number_list": [ { "id": "2.3.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.13", "type": "external" }, { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.5.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.44", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0003810 protein-glutamine gamma-glutamyltransferase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0031012 extracellular matrix", "go_biological_process": "GO:0018149 peptide cross-linking;GO:0042628 mating plug formation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q99041-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A9CMA6-1", "uniprot_id": [ { "id": "TM163_RAT", "url": "https://www.uniprot.org/uniprot/A9CMA6", "type": "external" } ], "mass": 31344.0, "length": 288, "protein_name": "Transmembrane protein 163", "gene_name": "Tmem163", "organism": "Rat", "refseq_name": "transmembrane protein 163", "refseq_ac": [ { "id": "NP_001104233", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104233", "type": "external" } ], "gene_names_uniprotkb": "Tmem163; Sv31", "gene_names_refseq": "RGD1306212; Sv31; Tmem163", "protein_names_uniprotkb": "Transmembrane protein 163; Synaptic vesicle membrane protein of 31 kDa", "protein_names_refseq": "synaptic vesicle membrane protein of 31 kDa; synaptic vesicle protein of 30 kD; transmembrane protein 163", "tax_id": 10116, "disease": "hypomyelinating leukodystrophy 25 (Disease Ontology:DOID:0070401); proteinuria (Disease Ontology:DOID:576)", "pathway": " (rno:360839)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17623043;18064521;20053882;21668449;22673903;27917477", "class_list": "", "function": "Identification and characterization of SV31, a novel synaptic vesicle membrane protein of 31 kDa with six putative transmembrane helices that, according to its membrane topology and phylogenetic relation, may function as a vesicular transporter, [RefSeq, PubMed]; SV31 represents a novel Zn(2+) -binding protein that in PC12 cells is targeted to endosomes and subpopulations of synaptic-like microvesicles, [RefSeq, PubMed]; That the synaptic vesicle-integral protein SV31 functions as a proton-dependent Zn(2+) transporter, [RefSeq, PubMed]; Zinc ion transporter that mediates zinc efflux and plays a crucial role in intracellular zinc homeostasis (By similarity). Binds the divalent cations Zn(2+), Ni(2+), and to a minor extent Cu(2+) (PubMed:21668449). Is a functional modulator of P2X purinoceptors, including P2RX1, P2RX3, P2RX4 and P2RX7 (By similarity). Plays a role in central nervous system development and is required for myelination, and survival and proliferation of oligodendrocytes (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0097708 intracellular vesicle;GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane", "go_biological_process": "GO:0042552 myelination;GO:0006882 intracellular zinc ion homeostasis;GO:0099180 zinc ion import into synaptic vesicle;GO:0140882 zinc export across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A9CMA6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B5DF41-1", "uniprot_id": [ { "id": "SNPH_RAT", "url": "https://www.uniprot.org/uniprot/B5DF41", "type": "external" } ], "mass": 54494.0, "length": 504, "protein_name": "Syntaphilin", "gene_name": "Snph", "organism": "Rat", "refseq_name": "syntaphilin", "refseq_ac": [ { "id": "NP_001099995", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099995", "type": "external" } ], "gene_names_uniprotkb": "Snph", "gene_names_refseq": "Snph", "protein_names_uniprotkb": "Syntaphilin", "protein_names_refseq": "syntaphilin", "tax_id": 10116, "disease": "", "pathway": " (rno:296267)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12896979;14985338;22673903;28472658;34193962;38843836", "class_list": "", "function": "Identification of a novel interaction of FUS and syntaphilin may explain synaptic and mitochondrial abnormalities caused by ALS mutations. Publication Status: Online-Only, [RefSeq, PubMed]; Inhibits SNARE complex formation by absorbing free STX1A., [UniProtKB, UniProtKB]; Stressed mitochondria are removed from axons triggered by the bulk release of mitochondrial anchoring protein syntaphilin via a new class of mitochondria-derived cargos independent of Parkin, Drp1, and autophagy., [RefSeq, PubMed]; Syntaphilin was identified as a molecular clamp that controls free syntaxin-1 and dynamin-1 availability and thereby regulates synaptic vesicle exocytosis and endocytosis. PKA phosphorylation of syntaphilin decreases its binding to syntaxin-1A in vitro., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane;GO:0043025 neuronal cell body;GO:0043005 neuron projection", "go_biological_process": "GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "B5DF41-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63199-1", "uniprot_id": [ { "id": "TNR6_RAT", "url": "https://www.uniprot.org/uniprot/Q63199", "type": "external" } ], "mass": 36835.0, "length": 324, "protein_name": "Tumor necrosis factor receptor superfamily member 6", "gene_name": "Fas", "organism": "Rat", "refseq_name": "tumor necrosis factor receptor superfamily member 6 precursor", "refseq_ac": [ { "id": "NP_631933", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_631933", "type": "external" } ], "gene_names_uniprotkb": "Fas; Apt1; Tnfrsf6", "gene_names_refseq": "FasR; Fas; Tnfrsf6", "protein_names_uniprotkb": "Tumor necrosis factor receptor superfamily member 6; Apo-1 antigen; Apoptosis-mediating surface antigen FAS; FASLG receptor", "protein_names_refseq": "CD95 antigen; FASLG receptor; Fas (TNF receptor superfamily, member 6); Fas antigen (ATP1); Fas receptor; Tumor necrosis factor receptor superfamily, member 6; apo-1 antigen; apoptosis-mediating surface antigen FAS; tumor necrosis factor receptor superfamily member 6 precursor; tumor necrosis factor receptor superfamily member 6", "tax_id": 10116, "disease": "adult T-cell leukemia/lymphoma (Disease Ontology:DOID:0050523); chorioamnionitis (Disease Ontology:DOID:0050697); myelodysplastic syndrome (Disease Ontology:DOID:0050908); pre-malignant neoplasm (Disease Ontology:DOID:0060071); brain glioma (Disease Ontology:DOID:0060108); lymphoproliferative syndrome (Disease Ontology:DOID:0060704); alcohol-associated liver disease (Disease Ontology:DOID:0070658); nasal type extranodal NK/T-cell lymphoma (Disease Ontology:DOID:0080797); graft-versus-host disease (Disease Ontology:DOID:0081267); dermatomyositis (Disease Ontology:DOID:10223); prostate cancer (Disease Ontology:DOID:10283); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); gastric ulcer (Disease Ontology:DOID:10808); urinary bladder cancer (Disease Ontology:DOID:11054); cryptorchidism (Disease Ontology:DOID:11383); sciatic neuropathy (Disease Ontology:DOID:11446); diabetic angiopathy (Disease Ontology:DOID:11713); primary biliary cholangitis (Disease Ontology:DOID:12236); male infertility (Disease Ontology:DOID:12336); varicocele (Disease Ontology:DOID:12337); alcoholic hepatitis (Disease Ontology:DOID:12351); Graves' disease (Disease Ontology:DOID:12361); aplastic anemia (Disease Ontology:DOID:12449); Huntington's disease (Disease Ontology:DOID:12858); Sjogren's syndrome (Disease Ontology:DOID:12894); dilated cardiomyopathy (Disease Ontology:DOID:12930); HELLP syndrome (Disease Ontology:DOID:13133); Behcet's disease (Disease Ontology:DOID:13241); clonorchiasis (Disease Ontology:DOID:13767); abdominal obesity-metabolic syndrome 1 (Disease Ontology:DOID:14221); Parkinson's disease (Disease Ontology:DOID:14330); cystic fibrosis (Disease Ontology:DOID:1485); breast cancer (Disease Ontology:DOID:1612); glaucoma (Disease Ontology:DOID:1686); melanoma (Disease Ontology:DOID:1909); atherosclerosis (Disease Ontology:DOID:1936); hepatitis B (Disease Ontology:DOID:2043); autoimmune hepatitis (Disease Ontology:DOID:2048); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); multiple sclerosis (Disease Ontology:DOID:2377); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); ovarian cancer (Disease Ontology:DOID:2394); chronic conjunctivitis (Disease Ontology:DOID:2475); transitional cell carcinoma (Disease Ontology:DOID:2671); asthma (Disease Ontology:DOID:2841); IgA glomerulonephritis (Disease Ontology:DOID:2986); acute kidney failure (Disease Ontology:DOID:3021); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); peripheral vascular disease (Disease Ontology:DOID:341); inclusion body myositis (Disease Ontology:DOID:3429); breast carcinoma (Disease Ontology:DOID:3459); mixed connective tissue disease (Disease Ontology:DOID:3492); lung adenocarcinoma (Disease Ontology:DOID:3910); liver disease (Disease Ontology:DOID:409); myasthenia gravis (Disease Ontology:DOID:437); seminoma (Disease Ontology:DOID:4440); macular degeneration (Disease Ontology:DOID:4448); renal cell carcinoma (Disease Ontology:DOID:4450); endophthalmitis (Disease Ontology:DOID:4692); multiple system atrophy (Disease Ontology:DOID:4752); esophagus adenocarcinoma (Disease Ontology:DOID:4914); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); retinal detachment (Disease Ontology:DOID:5327); congestive heart failure (Disease Ontology:DOID:6000); autoimmune lymphoproliferative syndrome (Disease Ontology:DOID:6688); hepatocellular carcinoma (Disease Ontology:DOID:684); hepatoblastoma (Disease Ontology:DOID:687); rheumatoid arthritis (Disease Ontology:DOID:7148); retinoblastoma (Disease Ontology:DOID:768); cataract (Disease Ontology:DOID:83); chronic myeloid leukemia (Disease Ontology:DOID:8552); infectious mononucleosis (Disease Ontology:DOID:8568); ulcerative colitis (Disease Ontology:DOID:8577); autoimmune thrombocytopenic purpura (Disease Ontology:DOID:8924); systemic lupus erythematosus (Disease Ontology:DOID:9074); acute myeloid leukemia (Disease Ontology:DOID:9119); Barrett's esophagus (Disease Ontology:DOID:9206); ocular hypertension (Disease Ontology:DOID:9282); type 1 diabetes mellitus (Disease Ontology:DOID:9744); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:246097); (R-RNO-3371378); (R-RNO-5218900); (R-RNO-69416); (R-RNO-75157)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "15383280;31155748;33847039;33994507;37855249;7507668", "class_list": "", "function": "Fas, Caspase-8, and Caspase-9 pathway-mediated bile acid-induced fetal cardiomyocyte apoptosis in intrahepatic cholestasis pregnant rat models., [RefSeq, PubMed]; Let-7a promotes periodontal bone regeneration of bone marrow mesenchymal stem cell aggregates via the Fas/FasL-autophagy pathway., [RefSeq, PubMed]; MiR-448-5p/VEGFA Axis Protects Cardiomyocytes from Hypoxia Through Regulating the FAS/FAS-L Signaling Pathway., [RefSeq, PubMed]; Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase CASP8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs CASP8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both (By similarity)., [UniProtKB, UniProtKB]; The physiological release and pharmacological concentration of melatonin may improve protective effect of RIPerC against I/R-induced infarct size by modulating Cybb, Fas, NfkappaB, Irisin signaling pathways. Erratum:[J Pineal Res. 2019 Nov;67(4):e12609. doi: 10.1111/jpi.12609. PMID: 31657078], [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 84, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0004888 transmembrane signaling receptor activity;GO:0005516 calmodulin binding;GO:0042802 identical protein binding;GO:0019900 kinase binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030141 secretory granule", "go_biological_process": "GO:0002931 response to ischemia;GO:0007283 spermatogenesis;GO:0032496 response to lipopolysaccharide;GO:0042127 regulation of cell population proliferation;GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q63199-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51868-1", "uniprot_id": [ { "id": "CASQ2_RAT", "url": "https://www.uniprot.org/uniprot/P51868", "type": "external" } ], "mass": 47839.0, "length": 413, "protein_name": "Calsequestrin-2", "gene_name": "Casq2", "organism": "Rat", "refseq_name": "calsequestrin-2 precursor", "refseq_ac": [ { "id": "NP_058827", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058827", "type": "external" } ], "gene_names_uniprotkb": "Casq2", "gene_names_refseq": "Casq2; cardCSQ", "protein_names_uniprotkb": "Calsequestrin-2; Calsequestrin, cardiac muscle isoform", "protein_names_refseq": "SR calcium binding protein; calsequestrin 2 (cardiac muscle); calsequestrin-2 precursor", "tax_id": 10116, "disease": "catecholaminergic polymorphic ventricular tachycardia 2 (Disease Ontology:DOID:0060676); supravalvular aortic stenosis (Disease Ontology:DOID:1929); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (rno:29209); (R-RNO-2672351); (R-RNO-5578775)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "21431367;22673903;23876860;28169003;34502162;8042990", "class_list": "", "function": "Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle (PubMed:8042990). Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The exacerbated diastolic Ca(2+) leak and arrhythmogenic activities were related to a diminished expression of calsequestrin along with increased SERCA pump activity, which, in effect, promoted a gain-of-function in RyRs without alterations in SR Ca(2+) load, RyR expression or its Ca(2+) sensitivity., [RefSeq, PubMed]; We propose that cocaine accumulates in SR through its affinity for CASQ2 and affects both sasrcoplasmic reticulum Ca(2+) storage and release by altering the normal CASQ2 Ca(2+)-dependent polymerization, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O09177;Q6IMX1", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0048306 calcium-dependent protein binding;GO:0005080 protein kinase C binding;GO:0005509 calcium ion binding;GO:0140314 calcium ion sequestering activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030018 Z disc;GO:0016529 sarcoplasmic reticulum;GO:0033018 sarcoplasmic reticulum lumen;GO:0030314 junctional membrane complex", "go_biological_process": "GO:0006874 intracellular calcium ion homeostasis;GO:0060306 regulation of membrane repolarization;GO:0060048 cardiac muscle contraction;GO:0043267 negative regulation of potassium ion transport;GO:0045214 sarcomere organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P51868-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62627-1", "uniprot_id": [ { "id": "PAWR_RAT", "url": "https://www.uniprot.org/uniprot/Q62627", "type": "external" } ], "mass": 35866.0, "length": 332, "protein_name": "PRKC apoptosis WT1 regulator protein", "gene_name": "Pawr", "organism": "Rat", "refseq_name": "PRKC apoptosis WT1 regulator protein", "refseq_ac": [ { "id": "NP_277020", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_277020", "type": "external" } ], "gene_names_uniprotkb": "Pawr; Par4", "gene_names_refseq": "Par-4; Par4; Pawr", "protein_names_uniprotkb": "PRKC apoptosis WT1 regulator protein; Par-4; Prostate apoptosis response 4 protein; Transcriptional repressor Par-4-like protein PAWR", "protein_names_refseq": "PRKC apoptosis WT1 regulator protein; PRKC, apoptosis, WT1, regulator; Prostate apoptosis response protein 4; par-4 induced by effectors of apoptosis; prostate apoptosis response 4 protein; transcriptional repressor Par-4-like protein PAWR", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); major depressive disorder (Disease Ontology:DOID:1470); depressive disorder (Disease Ontology:DOID:1596); epilepsy (Disease Ontology:DOID:1826); transient cerebral ischemia (Disease Ontology:DOID:224); middle cerebral artery infarction (Disease Ontology:DOID:3525); cholangiocarcinoma (Disease Ontology:DOID:4947)", "pathway": " (rno:64513)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12897127;15657440;15817164;19625447;23219599;24457960;29854833;8043520", "class_list": "", "function": "Par-4 binding does not block MYPT1 phosphorylation in rat caudal arterial smooth muscle., [RefSeq, PubMed]; Phosphorylation by CK2 impairs Par-4 proapoptotic functions. Publication Status: Online-Only, [RefSeq, PubMed]; Pro-apoptotic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Also seems to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1 (By similarity)., [UniProtKB]; This study shows that downregulation of iNOS, IL-1beta, and P2X7 expression in mast cells via activation of PAR4 contributes to the Inhibition of visceral hyperalgesia Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0019899 enzyme binding;GO:0005080 protein kinase C binding;GO:0043522 leucine zipper domain binding;GO:0008157 protein phosphatase 1 binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005884 actin filament;GO:0030424 axon", "go_biological_process": "GO:0090281 negative regulation of calcium ion import;GO:1903238 positive regulation of leukocyte tethering or rolling;GO:1901300 positive regulation of hydrogen peroxide-mediated programmed cell death;GO:0060450 positive regulation of hindgut contraction;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q62627-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R186-1", "uniprot_id": [ { "id": "TRPV6_RAT", "url": "https://www.uniprot.org/uniprot/Q9R186", "type": "external" } ], "mass": 87362.0, "length": 767, "protein_name": "Transient receptor potential cation channel subfamily V member 6", "gene_name": "Trpv6", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Trpv6", "gene_names_refseq": "", "protein_names_uniprotkb": "Transient receptor potential cation channel subfamily V member 6; CaT1; Calcium transport protein 1; ECaC2; Epithelial calcium channel 2; TrpV6", "protein_names_refseq": "", "tax_id": 10116, "disease": "pre-eclampsia (Disease Ontology:DOID:10591); gestational diabetes (Disease Ontology:DOID:11714); hyperparathyroidism (Disease Ontology:DOID:13543)", "pathway": " (rno:114246); (R-RNO-3295583)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10428857;11287959;17197020;27296226;28878326;29258289", "class_list": "", "function": "Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine (PubMed:10428857, PubMed:11287959, PubMed:27296226, PubMed:28878326). Important for normal Ca(2+) ion homeostasis in the body, including bone and skin (By similarity). The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification (PubMed:10428857, PubMed:11287959, PubMed:27296226). Inactivation includes both a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0005516 calmodulin binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0005227 calcium-activated cation channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0034704 calcium channel complex", "go_biological_process": "GO:0051289 protein homotetramerization;GO:0051592 response to calcium ion;GO:0006816 calcium ion transport;GO:0070588 calcium ion transmembrane transport;GO:0055074 calcium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9R186-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62639-1", "uniprot_id": [ { "id": "RHEB_RAT", "url": "https://www.uniprot.org/uniprot/Q62639", "type": "external" } ], "mass": 20479.0, "length": 184, "protein_name": "GTP-binding protein Rheb", "gene_name": "Rheb", "organism": "Rat", "refseq_name": "GTP-binding protein Rheb", "refseq_ac": [ { "id": "NP_037348", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037348", "type": "external" } ], "gene_names_uniprotkb": "Rheb", "gene_names_refseq": "Rheb", "protein_names_uniprotkb": "GTP-binding protein Rheb; 3.6.5.-; Ras homolog enriched in brain", "protein_names_refseq": "GTP-binding protein Rheb; Ras homolog enriched in brain", "tax_id": 10116, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); tuberous sclerosis (Disease Ontology:DOID:13515); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:26954); (R-RNO-1632852); (R-RNO-165159); (R-RNO-166208); (R-RNO-380972); (R-RNO-5628897); (R-RNO-8943724); (R-RNO-9639288)", "pathway_count": 8, "publication_count": 5, "publication_id_list": "20685651;28025572;29287199;34673407;8206940", "class_list": "", "function": "Inhibition of miR-155 may play protective roles in ischemic stroke by phosphorylating S6K through the Rheb/mTOR pathway. Publication Status: Online-Only, [RefSeq, PubMed]; MiR-155 promotes cadmium-induced autophagy in rat hepatocytes by suppressing Rheb expression., [RefSeq, PubMed]; Small GTPase that acts as an allosteric activator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth. In response to nutrients, growth factors or amino acids, specifically activates the protein kinase activity of MTOR, the catalytic component of the mTORC1 complex: acts by causing a conformational change that allows the alignment of residues in the active site of MTOR, thereby enhancing the phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1). RHEB is also required for localization of the TSC-TBC complex to lysosomal membranes. In response to starvation, RHEB is inactivated by the TSC-TBC complex, preventing activation of mTORC1. Has low intrinsic GTPase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The regulation of Rheb-mTOR signal pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding;GO:0030295 protein kinase activator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0048714 positive regulation of oligodendrocyte differentiation;GO:0009615 response to virus;GO:0007264 small GTPase-mediated signal transduction;GO:0031669 cellular response to nutrient levels", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q62639-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35433-1", "uniprot_id": [ { "id": "TRPV1_RAT", "url": "https://www.uniprot.org/uniprot/O35433", "type": "external" } ], "mass": 94948.0, "length": 838, "protein_name": "Transient receptor potential cation channel subfamily V member 1", "gene_name": "Trpv1", "organism": "Rat", "refseq_name": "transient receptor potential cation channel subfamily V member 1", "refseq_ac": [ { "id": "NP_114188", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114188", "type": "external" } ], "gene_names_uniprotkb": "Trpv1; Vr1l; Vr1", "gene_names_refseq": "TRPV1_SON; Trpv1; VR.5'sv; Vr1l1; Vr1", "protein_names_uniprotkb": "Transient receptor potential cation channel subfamily V member 1; Capsaicin receptor; OTRPC1; Osm-9-like TRP channel 1; TrpV1; Vanilloid receptor 1; Vanilloid receptor type 1-like", "protein_names_refseq": "OTRPC1; capsaicin receptor; deltaN-TRPV1; osm-9-like TRP channel 1; transient receptor potential cation channel subfamily V member 1; transient receptor potential vanilloid 1 supraoptic nucleus; vanilloid receptor 1; vanilloid receptor subtype 1; vanilloid receptor type 1 like protein 1; vanilloid type 1 receptor", "tax_id": 10116, "disease": "overactive bladder syndrome (Disease Ontology:DOID:0070355); gastric ulcer (Disease Ontology:DOID:10808); sciatic neuropathy (Disease Ontology:DOID:11446); reflex epilepsy (Disease Ontology:DOID:2548); myocardial infarction (Disease Ontology:DOID:5844); migraine (Disease Ontology:DOID:6364); cocaine abuse (Disease Ontology:DOID:809); diabetic neuropathy (Disease Ontology:DOID:9743); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (rno:83810); (R-RNO-3295583)", "pathway_count": 2, "publication_count": 41, "publication_id_list": "10644739;10931826;11140687;11418861;11549313;11578842;11683872;11884385;12095983;12194871;12228246;12764195;12808128;14523239;14630912;14996838;15084474;15173182;15190102;15471852;15857679;15931076;16564619;17582331;18391945;20510930;21076423;22789851;23109716;24305160;24305161;25451626;26376215;26970286;27281200;29930087;33180962;38497183;38615746;39226353;9349813", "class_list": "", "function": "Ammonium chloride-induced hypothermia is attenuated by transient receptor potential channel vanilloid-1, but augmented by ankyrin-1 in rodents., [RefSeq, PubMed]; Does not display channel activity in response to noxious chemical compounds, such as capsaicin and the vanilloid resiniferatoxin. Channel activity is not elicited by mildly acidic extracellular pH, and only slight channel activity is observed in response to noxiuos heat stimuli., [UniProtKB, PubMed]; Low-Level miR-199 Contribute to Neuropathic Low Back Pain via TRPV1 by Regulating the Production of Pro-Inflammatory Cytokines on Macrophage., [RefSeq, PubMed]; Non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius (By similarity). Upon activation, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; TRPV1 corneal neuralgia mutation: Enhanced pH response, bradykinin sensitization, and capsaicin desensitization., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 1, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 29, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q920B3;Q920B4;Q9JLM0;Q9JM56;Q9JM57", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0005216 monoatomic ion channel activity;GO:0005262 calcium channel activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030425 dendrite", "go_biological_process": "GO:0050954 sensory perception of mechanical stimulus;GO:0001660 fever generation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001659 temperature homeostasis;GO:0001774 microglial cell activation", "synthesized_glycan_count": 0, "hit_score": 4.3, "record_id": "O35433-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.1000100000001.110.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08644-1", "uniprot_id": [ { "id": "RASK_RAT", "url": "https://www.uniprot.org/uniprot/P08644", "type": "external" } ], "mass": 21656.0, "length": 189, "protein_name": "GTPase KRas", "gene_name": "Hras; Kras; Nras", "organism": "Rat", "refseq_name": "GTPase KRas", "refseq_ac": [ { "id": "NP_113703", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113703", "type": "external" } ], "gene_names_uniprotkb": "Hras; Kras; Nras; Hras; Kras2; Kras", "gene_names_refseq": "K-ras; Kras2; Kras; c-Ki-ras; p21", "protein_names_uniprotkb": "GTPase KRas; 3.6.5.2; K-Ras 2; Ki-Ras; c-K-ras; c-Ki-ras", "protein_names_refseq": "GTPase KRas; K-Ras 2; Kirsten rat sarcoma viral oncogene homologue 2 (active); c-K-ras2 protein; c-Kirsten-ras proto-oncogene; ki-Ras; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog", "tax_id": 10116, "disease": "juvenile myelomonocytic leukemia (Disease Ontology:DOID:0050458); Costello syndrome (Disease Ontology:DOID:0050469); cardiomyopathy (Disease Ontology:DOID:0050700); renal fibrosis (Disease Ontology:DOID:0050855); hepatocellular adenoma (Disease Ontology:DOID:0050868); cardiofaciocutaneous syndrome (Disease Ontology:DOID:0060233); Noonan syndrome 3 (Disease Ontology:DOID:0060581); arteriovenous malformations of the brain (Disease Ontology:DOID:0060688); endometrial hyperplasia (Disease Ontology:DOID:0080365); RASopathy (Disease Ontology:DOID:0080690); autoimmune lymphoproliferative syndrome type 4 (Disease Ontology:DOID:0110117); epidermal nevus (Disease Ontology:DOID:0111162); large congenital melanocytic nevus (Disease Ontology:DOID:0111359); cardiofaciocutaneous syndrome 2 (Disease Ontology:DOID:0111461); linear nevus sebaceous syndrome (Disease Ontology:DOID:0111530); oculoectodermal syndrome (Disease Ontology:DOID:0111705); intestinal cancer (Disease Ontology:DOID:10155); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); intellectual disability (Disease Ontology:DOID:1059); Alzheimer's disease (Disease Ontology:DOID:10652); obsessive-compulsive disorder (Disease Ontology:DOID:10933); urinary bladder cancer (Disease Ontology:DOID:11054); heart disease (Disease Ontology:DOID:114); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); leukemia (Disease Ontology:DOID:1240); autistic disorder (Disease Ontology:DOID:12849); lung cancer (Disease Ontology:DOID:1324); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); squamous cell carcinoma (Disease Ontology:DOID:1749); pancreatic cancer (Disease Ontology:DOID:1793); autoimmune hepatitis (Disease Ontology:DOID:2048); kidney cancer (Disease Ontology:DOID:263); transitional cell carcinoma (Disease Ontology:DOID:2671); endometrial adenocarcinoma (Disease Ontology:DOID:2870); endometrial carcinoma (Disease Ontology:DOID:2871); endometriosis (Disease Ontology:DOID:289); carcinoma (Disease Ontology:DOID:305); glioblastoma (Disease Ontology:DOID:3068); malignant astrocytoma (Disease Ontology:DOID:3069); high grade glioma (Disease Ontology:DOID:3070); anaplastic astrocytoma (Disease Ontology:DOID:3078); skin benign neoplasm (Disease Ontology:DOID:3165); Noonan syndrome (Disease Ontology:DOID:3490); Lynch syndrome (Disease Ontology:DOID:3883); lung adenocarcinoma (Disease Ontology:DOID:3910); papillary thyroid carcinoma (Disease Ontology:DOID:3969); cervical cancer (Disease Ontology:DOID:4362); seminoma (Disease Ontology:DOID:4440); renal cell carcinoma (Disease Ontology:DOID:4450); pancreatic carcinoma (Disease Ontology:DOID:4905); bronchiolo-alveolar adenocarcinoma (Disease Ontology:DOID:4926); Klatskin's tumor (Disease Ontology:DOID:4927); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); liver cirrhosis (Disease Ontology:DOID:5082); stomach carcinoma (Disease Ontology:DOID:5517); phobic disorder (Disease Ontology:DOID:591); fibrillary astrocytoma (Disease Ontology:DOID:6726); hepatocellular carcinoma (Disease Ontology:DOID:684); liver carcinoma (Disease Ontology:DOID:686); pancreatic mucinous cystadenoma (Disease Ontology:DOID:7235); muscular atrophy (Disease Ontology:DOID:767); myeloid sarcoma (Disease Ontology:DOID:8683); diabetic retinopathy (Disease Ontology:DOID:8947); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:24525); (R-RNO-1169092); (R-RNO-1250347); (R-RNO-1433557); (R-RNO-171007); (R-RNO-179812); (R-RNO-180336); (R-RNO-186763); (R-RNO-1963640); (R-RNO-210993); (R-RNO-2179392); (R-RNO-2424491); (R-RNO-2871796); (R-RNO-375165); (R-RNO-4086398); (R-RNO-5218921); (R-RNO-5621575); (R-RNO-5654688); (R-RNO-5654693); (R-RNO-5654699); (R-RNO-5654700); (R-RNO-5654704); (R-RNO-5654706); (R-RNO-5654712); (R-RNO-5654719); (R-RNO-5658442); (R-RNO-5673000); (R-RNO-5673001); (R-RNO-5674135); (R-RNO-5675221); (R-RNO-8849471); (R-RNO-8851805); (R-RNO-9607240); (R-RNO-9634635); (R-RNO-9648002); (R-RNO-9674555)", "pathway_count": 36, "publication_count": 10, "publication_id_list": "12594205;19319189;29959233;3009041;3023884;3110778;31994822;33675084;36044972;8058308", "class_list": "", "function": "Selective Endothelial Hyperactivation of Oncogenic KRAS Induces Brain Arteriovenous Malformations in Mice., [RefSeq, PubMed]; Self-limiting bidirectional positive feedback between P53 and P21 is involved in cardiac hypertrophy., [RefSeq, PubMed]; Signal transducer in the Ras-MAPK signaling pathway that regulates cell proliferation and survival (PubMed:3110778). Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Activates MAPK1/MAPK3 resulting in phosphorylation and ultimately degradation of GJA1 (PubMed:29959233). Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner (By similarity). Recognized by LZTR1 that mediates its ubiquitination by a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; Teolin, and in particular its metabolized product, may represent another natural product-derived therapeutic agent that acts against bladder cancer by upregulating p21 and inhibiting mTOR signaling, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 69, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P46203;P97914", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.4.26.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.26.1", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "2.5.1.58", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.58", "type": "external" }, { "id": "2.5.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.59", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "2.7.1.91", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.91", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.1.1.100", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.100", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0000164 protein phosphatase type 1 complex;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0001889 liver development;GO:0008284 positive regulation of cell population proliferation;GO:0008542 visual learning;GO:0010628 positive regulation of gene expression;GO:0035900 response to isolation stress", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P08644-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11101-1", "uniprot_id": [ { "id": "STP2_RAT", "url": "https://www.uniprot.org/uniprot/P11101", "type": "external" } ], "mass": 12848.0, "length": 114, "protein_name": "Nuclear transition protein 2", "gene_name": "Tnp2", "organism": "Rat", "refseq_name": "nuclear transition protein 2", "refseq_ac": [ { "id": "NP_058753", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058753", "type": "external" } ], "gene_names_uniprotkb": "Tnp2", "gene_names_refseq": "Tnp2", "protein_names_uniprotkb": "Nuclear transition protein 2; TP-2; TP2", "protein_names_refseq": "TP-2; TP2; haploid expressed, male germcell specific, chromatin binding; nuclear transition protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:24840)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10961985;11772016;14514679;17682055;1930189;19506090;19710011;2726489;3307778;8076694;8720108;8954887", "class_list": "", "function": "A detailed analysis to characterize the molecular components underlying the nuclear translocation of TP2, was carried out., [RefSeq, PubMed]; Acetylation of transition protein 2 (TP2) by KAT3B (p300) alters its DNA condensation property and interaction with putative histone chaperone NPM3., [RefSeq, PubMed]; Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals (PubMed:11772016). In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; TP1 and TP2 may have concerted functional roles during chromatin remodeling in mammalian spermiogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 13, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q64390;Q64561;Q6AYX7", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0000786 nucleosome", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007339 binding of sperm to zona pellucida;GO:0030317 flagellated sperm motility;GO:0010954 positive regulation of protein processing;GO:0007340 acrosome reaction", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P11101-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21707-1", "uniprot_id": [ { "id": "SYT1_RAT", "url": "https://www.uniprot.org/uniprot/P21707", "type": "external" } ], "mass": 47399.0, "length": 421, "protein_name": "Synaptotagmin-1", "gene_name": "Syt1", "organism": "Rat", "refseq_name": "synaptotagmin-1", "refseq_ac": [ { "id": "NP_001028852", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028852", "type": "external" } ], "gene_names_uniprotkb": "Syt1", "gene_names_refseq": "P65; Syt1", "protein_names_uniprotkb": "Synaptotagmin-1; Synaptotagmin I; SytI; p65", "protein_names_refseq": "synaptotagmin I; synaptotagmin-1; sytI", "tax_id": 10116, "disease": "congenital myasthenic syndrome 7 (Disease Ontology:DOID:0110659); congenital myasthenic syndrome (Disease Ontology:DOID:3635); neuromuscular junction disease (Disease Ontology:DOID:439)", "pathway": " (rno:25716); (R-RNO-181429); (R-RNO-181430); (R-RNO-210500); (R-RNO-212676); (R-RNO-264642); (R-RNO-8856825); (R-RNO-8856828); (R-RNO-888590)", "pathway_count": 9, "publication_count": 31, "publication_id_list": "10461881;11438518;11754837;11823420;11931641;12782290;14504267;15123599;15238157;15866046;17167418;17167421;17190793;1985919;20219474;22673903;2333096;25705886;25964652;28057568;30107533;32574643;33536412;35537054;35914553;38843836;7697723;8144634;8910372;9819203;9867811", "class_list": "", "function": "(Microbial infection) Receptor for C.botulinum neurotoxin type B (BoNT/B, botB); interaction is improved in the presence of gangliosides (PubMed:14504267, PubMed:17167418, PubMed:8144634). BoNT/B toxin binds to the membrane proximal vesicular domain of Syt1 (residues 32-51) (PubMed:14504267, PubMed:17167421)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; (Microbial infection) Receptor for C.botulinum neurotoxin type G (BoNT/G, botG); unlike the case with BoNT/B, interaction is not improved in the presence of gangliosides (PubMed:15123599, PubMed:20219474). BoNT/G toxin binds to the vesicular domain of Syt1 (residues 32-53) (PubMed:15123599, PubMed:20219474)., [UniProtKB, PubMed, PubMed]; Calcium sensor that participates in triggering neurotransmitter release at the synapse (PubMed:2333096, PubMed:30107533). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes., [UniProtKB, PubMed, UniProtKB, PubMed]; Calcium sensor that participates in triggering neurotransmitter release at the synapse. May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes., [UniProtKB, UniProtKB, UniProtKB]; Conserved arginine residues in synaptotagmin 1 regulate fusion pore expansion through membrane contact. Publication Status: Online-Only, [RefSeq, PubMed]; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone., [UniProtKB, UniProtKB, UniProtKB]; Synaptotagmin-1 is a bidirectional Ca(2+) sensor for neuronal endocytosis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3S2E6;Q707P5", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005543 phospholipid binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:1903861 positive regulation of dendrite extension;GO:0030100 regulation of endocytosis;GO:0030154 cell differentiation;GO:0051291 protein heterooligomerization;GO:0051592 response to calcium ion", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "P21707-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23693-1", "uniprot_id": [ { "id": "TNNI3_RAT", "url": "https://www.uniprot.org/uniprot/P23693", "type": "external" } ], "mass": 24160.0, "length": 211, "protein_name": "Troponin I, cardiac muscle", "gene_name": "Tnni3", "organism": "Rat", "refseq_name": "troponin I, cardiac muscle", "refseq_ac": [ { "id": "NP_058840", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058840", "type": "external" } ], "gene_names_uniprotkb": "Tnni3; Ctni; Tni", "gene_names_refseq": "TnI; Tnni3; cTNI", "protein_names_uniprotkb": "Troponin I, cardiac muscle; Cardiac troponin I", "protein_names_refseq": "cardiac troponin I; troponin 1, type 3; troponin I type 3 (cardiac); troponin I, cardiac muscle", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); stroke (Disease Ontology:DOID:0051061); hypertrophic cardiomyopathy 7 (Disease Ontology:DOID:0110313); dilated cardiomyopathy 1FF (Disease Ontology:DOID:0110459); dilated cardiomyopathy 2A (Disease Ontology:DOID:0110460); familial restrictive cardiomyopathy 1 (Disease Ontology:DOID:0111425); heart disease (Disease Ontology:DOID:114); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930); adenocarcinoma (Disease Ontology:DOID:299); coronary artery disease (Disease Ontology:DOID:3393); restrictive cardiomyopathy (Disease Ontology:DOID:397)", "pathway": " (rno:29248); (R-RNO-390522); (R-RNO-5578775)", "pathway_count": 3, "publication_count": 23, "publication_id_list": "15601779;15855227;17446435;1886137;18988896;1935696;19507043;1988058;20925105;22673903;22684024;26109417;26391394;26406887;30467191;32066368;33080242;33378032;34208541;34502162;34957754;35482324;9065755", "class_list": "", "function": "Altered expression levels of autophagy-associated proteins during exercise preconditioning indicate the involvement of autophagy in cardioprotection against exercise-induced myocardial injury. Publication Status: Online-Only, [RefSeq, PubMed]; Exercise-induced alterations of myocardial sarcomere dynamics are associated with hypophosphorylation of cardiac troponin I., [RefSeq, PubMed]; MiR-449 improves cardiac function by regulating HDAC1 and cTnI., [RefSeq, PubMed]; Phosphorylation of Troponin I finely controls the positioning of Troponin for the optimal regulation of cardiac muscle contraction., [RefSeq, PubMed]; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 12, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q4PP23", "ec_number_list": [], "go_molecular_function": "GO:0030172 troponin C binding;GO:0031014 troponin T binding;GO:0003779 actin binding;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:1990584 cardiac Troponin complex;GO:0005737 cytoplasm;GO:0030017 sarcomere;GO:0030016 myofibril;GO:0097512 cardiac myofibril", "go_biological_process": "GO:0001980 regulation of systemic arterial blood pressure by ischemic conditions;GO:0001570 vasculogenesis;GO:0003009 skeletal muscle contraction;GO:0006940 regulation of smooth muscle contraction;GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "P23693-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P45592-1", "uniprot_id": [ { "id": "COF1_RAT", "url": "https://www.uniprot.org/uniprot/P45592", "type": "external" } ], "mass": 18533.0, "length": 166, "protein_name": "Cofilin-1", "gene_name": "Cfl1", "organism": "Rat", "refseq_name": "cofilin-1", "refseq_ac": [ { "id": "NP_058843", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058843", "type": "external" } ], "gene_names_uniprotkb": "Cfl1", "gene_names_refseq": "Cfl1", "protein_names_uniprotkb": "Cofilin-1; Cofilin, non-muscle isoform", "protein_names_refseq": "cofilin 1, non-muscle; cofilin-1", "tax_id": 10116, "disease": "West syndrome (Disease Ontology:DOID:0050562); vitamin B12 deficiency (Disease Ontology:DOID:0050731); autism spectrum disorder (Disease Ontology:DOID:0060041); nemaline myopathy 7 (Disease Ontology:DOID:0110934); brain compression (Disease Ontology:DOID:11457); nephrotic syndrome (Disease Ontology:DOID:1184); alcohol use disorder (Disease Ontology:DOID:1574); status epilepticus (Disease Ontology:DOID:1824); impotence (Disease Ontology:DOID:1875); gallbladder carcinoma (Disease Ontology:DOID:4948); ureteral obstruction (Disease Ontology:DOID:5199); myocardial infarction (Disease Ontology:DOID:5844); muscular atrophy (Disease Ontology:DOID:767)", "pathway": " (rno:29271)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "28791377;28934273;29932353;30949027;31400829;32015554;34502162;9877327", "class_list": "", "function": "Actin depolymerizing factor (ADF)/cofilin controls actin turnover to sustain axon regeneration after spinal cord injury through its actin-severing activity. This pinpoints ADF/cofilin as a key regulator of axon growth competence, irrespective of developmental stage., [RefSeq, PubMed]; Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity (By similarity). Important for normal progress through mitosis and normal cytokinesis (By similarity). In conjunction with the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (By similarity). Required for the centralization of the mitotic spindle and symmetric division of zygotes (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization in epithelial cells (By similarity). Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (By similarity). Required for neural tube morphogenesis and neural crest cell migration (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; CMIP inhibits cofilin1 activity and alters podocyte cytoskeleton organization at least through RhoA signaling in PAinduced podocyte injury, [RefSeq, PubMed]; Global inhibition of neddylation in developing neurons leads to cytoskeletal defects, altered actin dynamics and neurite growth impairments, whereas site-specific neddylation of cofilin 1 at K112 regulates neurite outgrowth, suggesting that cofilin 1 neddylation contributes to the regulation of neuronal actin organization. Erratum:[Nat Struct Mol Biol. 2020 Apr;27(4):400. doi: 10.1038/s41594-020-0395-7. PMID: 32103165], [RefSeq, PubMed]; Identified cofilin rod, a pathological rod-like aggregation, formed in neurons of in vivo ischemic stroke animal model and induced neuronal impairment., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1902936 phosphatidylinositol bisphosphate binding;GO:0003779 actin binding;GO:0005102 signaling receptor binding;GO:0051015 actin filament binding;GO:0019903 protein phosphatase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0090732 cofilin-actin rod;GO:0005737 cytoplasm;GO:0005911 cell-cell junction;GO:0005925 focal adhesion", "go_biological_process": "GO:0001842 neural fold formation;GO:0098885 modification of postsynaptic actin cytoskeleton;GO:0030835 negative regulation of actin filament depolymerization;GO:0051293 establishment of spindle localization;GO:2000814 positive regulation of barbed-end actin filament capping", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P45592-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51156-1", "uniprot_id": [ { "id": "RAB26_RAT", "url": "https://www.uniprot.org/uniprot/P51156", "type": "external" } ], "mass": 28203.0, "length": 257, "protein_name": "Ras-related protein Rab-26", "gene_name": "Rab26", "organism": "Rat", "refseq_name": "ras-related protein Rab-26", "refseq_ac": [ { "id": "NP_598264", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598264", "type": "external" } ], "gene_names_uniprotkb": "Rab26", "gene_names_refseq": "Rab26", "protein_names_uniprotkb": "Ras-related protein Rab-26; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-26", "tax_id": 10116, "disease": "", "pathway": " (rno:171111); (R-RNO-8873719)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10857477;16076461;25643395;7864900", "class_list": "", "function": "Rab26 selectively directs synaptic and secretory vesicles into preautophagosomal structures. Publication Status: Online-Only, [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB26 mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach (By similarity). Plays a role in the secretion of amylase from acinar granules in the parotid gland (PubMed:10857477, PubMed:16076461)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P6W7", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0019002 GMP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0030667 secretory granule membrane", "go_biological_process": "GO:0045055 regulated exocytosis;GO:0016192 vesicle-mediated transport;GO:0043001 Golgi to plasma membrane protein transport;GO:0017157 regulation of exocytosis;GO:0035272 exocrine system development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P51156-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08850-1", "uniprot_id": [ { "id": "STX4_RAT", "url": "https://www.uniprot.org/uniprot/Q08850", "type": "external" } ], "mass": 34195.0, "length": 298, "protein_name": "Syntaxin-4", "gene_name": "Stx4", "organism": "Rat", "refseq_name": "syntaxin-4", "refseq_ac": [ { "id": "NP_112387", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112387", "type": "external" } ], "gene_names_uniprotkb": "Stx4; Stx4a", "gene_names_refseq": "Stx4a; Stx4", "protein_names_uniprotkb": "Syntaxin-4", "protein_names_refseq": "syntaxin 4A (placental); syntaxin-4", "tax_id": 10116, "disease": "autosomal recessive nonsyndromic deafness (Disease Ontology:DOID:0050565)", "pathway": " (rno:81803); (R-RNO-114516); (R-RNO-199992); (R-RNO-449836)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "12145319;14993220;18827011;22673903;27301714;27791016;28119011;32963038;7690687", "class_list": "", "function": "Our study uncovers the postsynaptic function of the SNAP25-VAMP1-syntaxin4 complex in mediating the constitutive exocytosis of NMDA receptors, suggesting that this SNARE complex is involved in excitatory synaptic transmission, [RefSeq, PubMed]; Plasma membrane t-SNARE that mediates docking of transport vesicles (By similarity). Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane (By similarity). In neurons, recruited at neurite tips to membrane domains rich in the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) which promotes neurite tip surface expression of the dopamine transporter SLC6A3/DAT by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane (PubMed:32963038). Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes and in docking of synaptic vesicles at presynaptic active zones (By similarity). Required for normal hearing (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. In neurons, recruited at neurite tips to membrane domains rich in the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) which promotes neurite tip surface expression of the dopamine transporter SLC6A3/DAT by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes and in docking of synaptic vesicles at presynaptic active zones. Required for normal hearing., [UniProtKB, UniProtKB]; Syntaxin-4 and CRACM3 interact in a non-excitable vesicle fusion.Extracellular loop 3 and the C-terminus of CRACM3 are critical for binding the N-peptide of syntaxin-4. Publication Status: Online-Only, [RefSeq, PubMed]; Syntaxin-4 and SNAP23 act as exocytic soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) to release nerve growth factors from cultured Schwann cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3V8I4", "ec_number_list": [], "go_molecular_function": "GO:0016230 sphingomyelin phosphodiesterase activator activity;GO:0031267 small GTPase binding;GO:0000149 SNARE binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0032589 neuron projection membrane;GO:0005615 extracellular space;GO:0005768 endosome;GO:0005886 plasma membrane", "go_biological_process": "GO:0048284 organelle fusion;GO:0006886 intracellular protein transport;GO:0008284 positive regulation of cell population proliferation;GO:0030335 positive regulation of cell migration;GO:0045785 positive regulation of cell adhesion", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q08850-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SWS8-1", "uniprot_id": [ { "id": "RAE1L_RAT", "url": "https://www.uniprot.org/uniprot/Q3SWS8", "type": "external" } ], "mass": 40919.0, "length": 368, "protein_name": "mRNA export factor", "gene_name": "Rae1", "organism": "Rat", "refseq_name": "mRNA export factor", "refseq_ac": [ { "id": "NP_001028880", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028880", "type": "external" } ], "gene_names_uniprotkb": "Rae1; Mrnp41", "gene_names_refseq": "Rae1", "protein_names_uniprotkb": "mRNA export factor; Rae1 protein homolog; mRNA-associated protein mrnp 41", "protein_names_refseq": "RAE1 RNA export 1 homolog; mRNA export factor; mRNA-associated protein mrnp 41; rae1 protein homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:362281); (R-RNO-159227); (R-RNO-159230); (R-RNO-159231); (R-RNO-159236); (R-RNO-170822); (R-RNO-1855170); (R-RNO-1855196); (R-RNO-1855229); (R-RNO-191859); (R-RNO-3108214); (R-RNO-3232142); (R-RNO-3301854); (R-RNO-3371453); (R-RNO-4085377); (R-RNO-4551638); (R-RNO-4570464); (R-RNO-4615885)", "pathway_count": 18, "publication_count": 1, "publication_id_list": "22357847", "class_list": "", "function": "Plays a role in mitotic bipolar spindle formation. Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0001650 fibrillar center", "go_biological_process": "GO:0051301 cell division;GO:0060236 regulation of mitotic spindle organization;GO:0006405 RNA export from nucleus;GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3SWS8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PQX1-1", "uniprot_id": [ { "id": "TOIP1_RAT", "url": "https://www.uniprot.org/uniprot/Q5PQX1", "type": "external" } ], "mass": 65649.0, "length": 583, "protein_name": "Torsin-1A-interacting protein 1", "gene_name": "Tor1aip1", "organism": "Rat", "refseq_name": "torsin-1A-interacting protein 1", "refseq_ac": [ { "id": "NP_659560", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659560", "type": "external" } ], "gene_names_uniprotkb": "Tor1aip1", "gene_names_refseq": "Lap1b; Lap1c; Tor1aip1", "protein_names_uniprotkb": "Torsin-1A-interacting protein 1; LAP1B; LAP1C; Lamina-associated polypeptide 1B; Lamina-associated polypeptide 1C", "protein_names_refseq": "lamina-associated polypeptide 1B; lamina-associated polypeptide 1C; torsin A interacting protein 1; torsin-1A-interacting protein 1", "tax_id": 10116, "disease": "autosomal recessive limb-girdle muscular dystrophy type 2Y (Disease Ontology:DOID:0110289)", "pathway": " (rno:246314); (R-RNO-9035034)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "14656723;16128803;22673903;24116158;7721789", "class_list": "", "function": "Data indicate that the protein phosphatase 1 (PP1) and nuclear membrane protein lamina associated polypeptide 1B (LAP1B) LAP1B:PP1 complex can be immunoprecipitated from cerebral cortex. Publication Status: Online-Only, [RefSeq, PubMed]; Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q62741;Q62754", "ec_number_list": [], "go_molecular_function": "GO:0051117 ATPase binding;GO:0008092 cytoskeletal protein binding;GO:0001671 ATPase activator activity;GO:0005521 lamin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0031965 nuclear membrane;GO:0005637 nuclear inner membrane", "go_biological_process": "GO:0090435 protein localization to nuclear envelope;GO:0034504 protein localization to nucleus;GO:0032781 positive regulation of ATP-dependent activity;GO:0071763 nuclear membrane organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q5PQX1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62835-1", "uniprot_id": [ { "id": "RABE2_RAT", "url": "https://www.uniprot.org/uniprot/Q62835", "type": "external" } ], "mass": 61973.0, "length": 554, "protein_name": "Rab GTPase-binding effector protein 2", "gene_name": "Rabep2", "organism": "Rat", "refseq_name": "rab GTPase-binding effector protein 2", "refseq_ac": [ { "id": "NP_085074", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_085074", "type": "external" } ], "gene_names_uniprotkb": "Rabep2; Rabpt5b", "gene_names_refseq": "Fra; MP13; Rabep2", "protein_names_uniprotkb": "Rab GTPase-binding effector protein 2; MP13 protein; Rabaptin-5beta", "protein_names_refseq": "Fos-related antigen; rab GTPase-binding effector protein 2; rabaptin-5beta", "tax_id": 10116, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (rno:80754)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11108998;11406124;11954661;15299028;22673903", "class_list": "", "function": "Effect of immunoneutralization of endogenous prolactin on expression of FRAs in the tuberoinfundibular dopaminergic, tuberohypophysial dopaminergic and periventricular hypothalamic dopaminergic subpopulations of the hypothalamic dopaminergic neurons, [RefSeq, PubMed]; Expression of Fos-related antigens is an indicator of neuronal activation in hypothalamic dopaminergic neurons after prolactin administration., [RefSeq, PubMed]; Fos-related antigen 2 has a role in controlling protein kinase A-induced CCAAT/enhancer-binding protein beta expression in osteoblasts, [RefSeq, PubMed]; Plays a role in membrane trafficking and in homotypic early endosome fusion. Participates in arteriogenesis by regulating vascular endothelial growth factor receptor 2/VEGFR2 cell surface expression and endosomal trafficking. By interacting with SDCCAG8, localizes to centrosomes and plays a critical role in ciliogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005813 centrosome;GO:0005829 cytosol;GO:0036064 ciliary basal body", "go_biological_process": "GO:0006897 endocytosis;GO:0015031 protein transport;GO:0030030 cell projection organization;GO:1902017 regulation of cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q62835-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63524-1", "uniprot_id": [ { "id": "TMED2_RAT", "url": "https://www.uniprot.org/uniprot/Q63524", "type": "external" } ], "mass": 22733.0, "length": 201, "protein_name": "Transmembrane emp24 domain-containing protein 2", "gene_name": "Tmed2", "organism": "Rat", "refseq_name": "transmembrane emp24 domain-containing protein 2 isoform 2 precursor", "refseq_ac": [ { "id": "NP_113910", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113910", "type": "external" } ], "gene_names_uniprotkb": "Tmed2; Rnp24", "gene_names_refseq": "Rnp24; Tmed2", "protein_names_uniprotkb": "Transmembrane emp24 domain-containing protein 2; COPI-coated vesicle membrane protein p24; Membrane protein p24A; RNP21.4; p24 family protein beta-1; p24beta1", "protein_names_refseq": "COPI-coated vesicle membrane protein p24; RNP21.4; coated vesicle membrane protein; membrane protein p24A; p24 family protein beta-1; p24beta1; transmembrane emp24 domain trafficking protein 2; transmembrane emp24 domain-containing protein 2 isoform 2 precursor; transmembrane emp24 domain-containing protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:65165); (R-RNO-1912420); (R-RNO-204005); (R-RNO-5694530); (R-RNO-6807878); (R-RNO-6811434)", "pathway_count": 6, "publication_count": 9, "publication_id_list": "10214941;11703931;11739402;11748249;15718469;17693410;21219331;8663407;9472029", "class_list": "", "function": "Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport inhibits the GTPase-activating activity of ARFGAP1 towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Facilitates CASR maturation and stabilization in the early secretory pathway and increases CASR plasma membrane targeting. Proposed to be involved in organization of intracellular membranes such as the maintenance of the Golgi apparatus. May also play a role in the biosynthesis of secreted cargo such as eventual processing (By similarity)., [UniProtKB, PubMed]; P24A is a regulator of signal-dependent trafficking that controls ARF1-dependent resensitization of PAR-2, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005109 frizzled binding;GO:0005119 smoothened binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:1903912 negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation;GO:0060717 chorion development;GO:0090158 endoplasmic reticulum membrane organization;GO:0001701 in utero embryonic development;GO:0006886 intracellular protein transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q63524-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYJ1-1", "uniprot_id": [ { "id": "RECQ1_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYJ1", "type": "external" } ], "mass": 69642.0, "length": 621, "protein_name": "ATP-dependent DNA helicase Q1", "gene_name": "Recql", "organism": "Rat", "refseq_name": "ATP-dependent DNA helicase Q1 isoform 3", "refseq_ac": [ { "id": "NP_001012098", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012098", "type": "external" } ], "gene_names_uniprotkb": "Recql; Recql1", "gene_names_refseq": "Recql", "protein_names_uniprotkb": "ATP-dependent DNA helicase Q1; 5.6.2.4; DNA 3'-5' helicase Q1; DNA-dependent ATPase Q1; RecQ protein-like 1", "protein_names_refseq": "ATP-dependent DNA helicase Q1 isoform 3; ATP-dependent DNA helicase Q1; DNA 3'-5' helicase Q1; DNA-dependent ATPase Q1; RecQ helicase-like; RecQ protein-like (DNA helicase Q1-like); recQ protein-like 1", "tax_id": 10116, "disease": "lung cancer (Disease Ontology:DOID:1324); pancreatic cancer (Disease Ontology:DOID:1793); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:312824)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "DNA helicase that plays a role in DNA damage repair and genome stability (By similarity). Exhibits a magnesium- and ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction (By similarity). Plays a role in restoring regressed replication forks (By similarity). Required to restart stalled replication forks induced by abortive topoisomerase 1 and 2 lesions (By similarity). May play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens (By similarity)., [UniProtKB, UniProtKB]; DNA helicase that plays a role in DNA damage repair and genome stability. Exhibits a magnesium- and ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction. Plays a role in restoring regressed replication forks. Required to restart stalled replication forks induced by abortive topoisomerase 1 and 2 lesions. May play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0043138 3'-5' DNA helicase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0003678 DNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005694 chromosome", "go_biological_process": "GO:0006260 DNA replication;GO:0000724 double-strand break repair via homologous recombination;GO:0031297 replication fork processing;GO:0006281 DNA repair;GO:0006310 DNA recombination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AYJ1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QXN2-1", "uniprot_id": [ { "id": "PAT14_RAT", "url": "https://www.uniprot.org/uniprot/Q9QXN2", "type": "external" } ], "mass": 10998.0, "length": 99, "protein_name": "Prostate and testis expressed protein 14", "gene_name": "Pate14", "organism": "Rat", "refseq_name": "prostate and testis expressed protein 14 precursor", "refseq_ac": [ { "id": "NP_612546", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612546", "type": "external" } ], "gene_names_uniprotkb": "Pate14; Sslp1", "gene_names_refseq": "Pate14l; Pate14; Sslp1l1; Sslp1", "protein_names_uniprotkb": "Prostate and testis expressed protein 14; Protein RSP-1; SSLP-1; Secreted seminal-vesicle Ly-6 protein 1; Spleen protein 1", "protein_names_refseq": "prostate and testis expressed protein 14 like; prostate and testis expressed protein 14 precursor; prostate and testis expressed protein 14; protein RSP-1; secreted seminal-vesicle Ly-6 protein 1 like; secreted seminal-vesicle Ly-6 protein 1; spleen protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:171573)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11840564", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9QXN2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QXY2-1", "uniprot_id": [ { "id": "SRCN1_RAT", "url": "https://www.uniprot.org/uniprot/Q9QXY2", "type": "external" } ], "mass": 129744.0, "length": 1197, "protein_name": "SRC kinase signaling inhibitor 1", "gene_name": "Srcin1", "organism": "Rat", "refseq_name": "SRC kinase signaling inhibitor 1 isoform 2", "refseq_ac": [ { "id": "NP_062251", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062251", "type": "external" } ], "gene_names_uniprotkb": "Srcin1; P140; Snip", "gene_names_refseq": "P140; Snip; Srcin1; p140Cap", "protein_names_uniprotkb": "SRC kinase signaling inhibitor 1; SNAP-25-interacting protein; SNIP; p130Cas-associated protein; p140Cap", "protein_names_refseq": "SNAP25-interacting protein; SRC kinase signaling inhibitor 1 isoform 2; p130Cas-associated protein", "tax_id": 10116, "disease": "cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (rno:56029)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10625663;18662323;18683930;19146815;22673903;24453341;28641114;30315850;38843836", "class_list": "", "function": "Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance., [UniProtKB, PubMed, PubMed]; Study demonstrates a critical role of presynaptic cadherin/catenin/p140Cap cell adhesion complexes in stabilizing functional synapses and spines in the developing neocortex., [RefSeq, PubMed]; Upregulation of miR-150 promoted angiogenesis and proliferation of endothelial progenitor cells by targeting SRCIN1 in vitro and thrombus resolution in vivo., [RefSeq, PubMed]; We here demonstrate that p140Cap is a key element for both learning and synaptic plasticity, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 37, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9QXY3", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0014069 postsynaptic density;GO:0015629 actin cytoskeleton;GO:0030027 lamellipodium", "go_biological_process": "GO:0050709 negative regulation of protein secretion;GO:0007162 negative regulation of cell adhesion;GO:0061098 positive regulation of protein tyrosine kinase activity;GO:0034446 substrate adhesion-dependent cell spreading;GO:0061099 negative regulation of protein tyrosine kinase activity", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9QXY2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48679-1", "uniprot_id": [ { "id": "LMNA_RAT", "url": "https://www.uniprot.org/uniprot/P48679", "type": "external" } ], "mass": 74324.0, "length": 665, "protein_name": "Prelamin-A/C", "gene_name": "Lmna", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Lmna; Lmn1", "gene_names_refseq": "", "protein_names_uniprotkb": "Prelamin-A/C", "protein_names_refseq": "", "tax_id": 10116, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); familial partial lipodystrophy (Disease Ontology:DOID:0050440); congenital muscular dystrophy (Disease Ontology:DOID:0050557); atrioventricular block (Disease Ontology:DOID:0050820); familial partial lipodystrophy type 2 (Disease Ontology:DOID:0070202); autosomal dominant Emery-Dreifuss muscular dystrophy 2 (Disease Ontology:DOID:0070247); autosomal recessive Emery-Dreifuss muscular dystrophy 3 (Disease Ontology:DOID:0070248); restrictive dermopathy 2 (Disease Ontology:DOID:0070370); aortic valve disease 2 (Disease Ontology:DOID:0080334); mandibuloacral dysplasia type A lipodystrophy (Disease Ontology:DOID:0081128); Charcot-Marie-Tooth disease type 2B1 (Disease Ontology:DOID:0110156); dilated cardiomyopathy 1A (Disease Ontology:DOID:0110425); congenital muscular dystrophy due to LMNA mutation (Disease Ontology:DOID:0110640); dilated cardiomyopathy-hypergonadotropic hypogonadism syndrome (Disease Ontology:DOID:0111584); otitis media (Disease Ontology:DOID:10754); lipoatrophic diabetes mellitus (Disease Ontology:DOID:11712); Emery-Dreifuss muscular dystrophy (Disease Ontology:DOID:11726); dilated cardiomyopathy (Disease Ontology:DOID:12930); transient cerebral ischemia (Disease Ontology:DOID:224); arteriosclerosis (Disease Ontology:DOID:2349); progeria (Disease Ontology:DOID:3911); myopathy (Disease Ontology:DOID:423); Werner syndrome (Disease Ontology:DOID:5688); muscle tissue disease (Disease Ontology:DOID:66); cerebrovascular disease (Disease Ontology:DOID:6713); lipodystrophy (Disease Ontology:DOID:811); achalasia (Disease Ontology:DOID:9164); type 2 diabetes mellitus (Disease Ontology:DOID:9352); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (rno:60374); (R-RNO-2980766); (R-RNO-2995383); (R-RNO-352238); (R-RNO-4419969)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "1426247;14991764;16128803;16641100;34502162;41549750", "class_list": "", "function": "Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane. Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties. The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively. Lamin A and C are present in equal amounts in the lamina of mammals. Also involved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation. Required for osteoblastogenesis and bone formation. Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone. Required for cardiac homeostasis., [UniProtKB, UniProtKB]; Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 49, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 29, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0042802 identical protein binding;GO:0008157 protein phosphatase 1 binding;GO:0160123 structural constituent of nuclear lamina", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0031965 nuclear membrane", "go_biological_process": "GO:0032204 regulation of telomere maintenance;GO:0090435 protein localization to nuclear envelope;GO:0007283 spermatogenesis;GO:0008285 negative regulation of cell population proliferation;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P48679-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88775-1", "uniprot_id": [ { "id": "EMB_RAT", "url": "https://www.uniprot.org/uniprot/O88775", "type": "external" } ], "mass": 37005.0, "length": 328, "protein_name": "Embigin", "gene_name": "Emb", "organism": "Rat", "refseq_name": "embigin precursor", "refseq_ac": [ { "id": "NP_446171", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446171", "type": "external" } ], "gene_names_uniprotkb": "Emb; Gp70", "gene_names_refseq": "Emb", "protein_names_uniprotkb": "Embigin", "protein_names_refseq": "embigin precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:114511); (R-RNO-433692)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "15917240;19164284;19473976;20695846;22673903;30446621;35257743;9169423;9438341", "class_list": "", "function": "Embigin enhances neural cell adhesion molecule-dependent neuromuscular adhesion and thereby modulates neuromuscular junction formation and plasticity., [RefSeq, PubMed]; Expression of active MCT2 at the plasma membrane of oocytes was significantly enhanced by co-expression of exogenous embigin., [RefSeq, PubMed]; MCT2 associates with gp70 and is insensitive to pCMBS; embigin (gp70) is an ancillary protein required to maintain the catalytic activity of MCT2, [RefSeq, PubMed]; Plays a role in the outgrowth of motoneurons and in the formation of neuromuscular junctions. Following muscle denervation, promotes nerve terminal sprouting and the formation of additional acetylcholine receptor clusters at synaptic sites without affecting terminal Schwann cell number or morphology. Delays the retraction of terminal sprouts following re-innervation of denervated endplates (By similarity). Plays a role in targeting the monocarboxylate transporters SLC16A1, SLC16A6 and SLC16A7 to the cell membrane., [UniProtKB, PubMed, PubMed, PubMed]; This study analyzed the direct interaction between CAIV and the two Monocarboxylate transporters (MCTs) chaperones basigin (CD147) and embigin (GP70)., [RefSeq, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0045202 synapse", "go_biological_process": "GO:0007155 cell adhesion;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007411 axon guidance;GO:0070593 dendrite self-avoidance;GO:0035879 plasma membrane lactate transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O88775-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10634-1", "uniprot_id": [ { "id": "CP2DQ_RAT", "url": "https://www.uniprot.org/uniprot/P10634", "type": "external" } ], "mass": 56684.0, "length": 500, "protein_name": "Cytochrome P450 2D26", "gene_name": "Cyp2d26; Cyp2d2", "organism": "Rat", "refseq_name": "cytochrome P450 2D26", "refseq_ac": [ { "id": "NP_036862", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036862", "type": "external" } ], "gene_names_uniprotkb": "Cyp2d26; Cyp2d2; Cyp2d-26; Cyp2d2", "gene_names_refseq": "CYPIID26; Cyp2d26; Cyp2d2; P450-CMF2; P450-DB2", "protein_names_uniprotkb": "Cytochrome P450 2D26; 1.14.14.1; CYPIID26; Cytochrome P450-CMF2; Cytochrome P450-DB2; Debrisoquine 4-hydroxylase", "protein_names_refseq": "Cytochrome P450, subfamily IID2; cytochrome P450 2D26; cytochrome P450, family 2, subfamily d, polypeptide 26; cytochrome P450-CMF2; cytochrome P450-DB2; debrisoquine 4-hydroxylase", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); extrapyramidal and movement disease (Disease Ontology:DOID:13839); major depressive disorder (Disease Ontology:DOID:1470); autoimmune hepatitis (Disease Ontology:DOID:2048); opiate dependence (Disease Ontology:DOID:2559); asthma (Disease Ontology:DOID:2841); rhinitis (Disease Ontology:DOID:4483); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); acute myeloid leukemia (Disease Ontology:DOID:9119); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:25053)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "2107330;22162298;22673903;2819073;29415952;3190674;3582092;39063146;8578766;9434752", "class_list": "", "function": "Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics., [UniProtKB]; It shows the highest metabolic activities against enantiomers of carvedilol., [RefSeq, PubMed]; Panax notoginseng saponins had no significant effects on the activities of CYP2C9, CYP2D6, and CYP3A4, but it could induce the activity of CYP1A2 in rats in vivo., [RefSeq, PubMed]; The Effect of Maternal High-Fat or High-Carbohydrate Diet during Pregnancy and Lactation on Cytochrome P450 2D (CYP2D) in the Liver and Brain of Rat Offspring. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" }, { "id": "1.14.14.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.-", "type": "external" }, { "id": "4.2.1.152", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.152", "type": "external" }, { "id": "1.14.13.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.n7", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0004497 monooxygenase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0007565 female pregnancy;GO:0009410 response to xenobiotic stimulus;GO:0019369 arachidonate metabolic process;GO:0033595 response to genistein", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P10634-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q69CM7-1", "uniprot_id": [ { "id": "MYBPP_RAT", "url": "https://www.uniprot.org/uniprot/Q69CM7", "type": "external" } ], "mass": 106345.0, "length": 928, "protein_name": "MYCBP-associated protein", "gene_name": "Mycbpap", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mycbpap; Cod106", "gene_names_refseq": "", "protein_names_uniprotkb": "MYCBP-associated protein; Organ of Corti membrane-associated protein of 106 kDa", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:494192)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15607946;22673903", "class_list": "", "function": "Plays a crucial role in centrosome-nuclear envelope docking during spermiogenesis, a key step for anchoring the centrosome to the nucleus that is essential for proper sperm flagellum biogenesis. Also required for acrosome biogenesis, manchette organization, and spermatid head morphogenesis, contributing to the complete and functional assembly of the sperm flagellum., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q69CM6", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0030276 clathrin binding", "go_cellular_component": "GO:0030125 clathrin vesicle coat;GO:1990716 axonemal central apparatus;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005886 plasma membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0007283 spermatogenesis;GO:0007268 chemical synaptic transmission;GO:0030317 flagellated sperm motility;GO:0001675 acrosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q69CM7-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1A5Q0-1", "uniprot_id": [ { "id": "LMOD2_RAT", "url": "https://www.uniprot.org/uniprot/A1A5Q0", "type": "external" } ], "mass": 61717.0, "length": 549, "protein_name": "Leiomodin-2", "gene_name": "Lmod2", "organism": "Rat", "refseq_name": "leiomodin-2", "refseq_ac": [ { "id": "NP_001094434", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094434", "type": "external" } ], "gene_names_uniprotkb": "Lmod2", "gene_names_refseq": "Lmod2", "protein_names_uniprotkb": "Leiomodin-2; C-LMOD; Cardiac leiomodin; Leiomodin", "protein_names_refseq": "C-LMOD; cardiac leiomodin; leiomodin 2 (cardiac); leiomodin-2-like; leiomodin-2", "tax_id": 10116, "disease": "dilated cardiomyopathy 2G (Disease Ontology:DOID:0081163); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (rno:296935)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "18403713;20685966;22673903", "class_list": "", "function": "Lmod contributes to the final organization and maintenance of sarcomere architecture by promoting tropomyosin-dependent actin filament nucleation., [RefSeq, PubMed]; Mediates nucleation of actin filaments and thereby promotes actin polymerization (PubMed:18403713). Plays a role in the regulation of actin filament length (By similarity). Required for normal sarcomere organization in the heart, and for normal heart function (PubMed:18403713)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0003785 actin monomer binding;GO:0005523 tropomyosin binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005884 actin filament;GO:0005865 striated muscle thin filament;GO:0030017 sarcomere;GO:0031430 M band", "go_biological_process": "GO:0006936 muscle contraction;GO:0007015 actin filament organization;GO:0030041 actin filament polymerization;GO:0045214 sarcomere organization;GO:0045010 actin nucleation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A1A5Q0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZD82-1", "uniprot_id": [ { "id": "DNJ5B_RAT", "url": "https://www.uniprot.org/uniprot/D3ZD82", "type": "external" } ], "mass": 22719.0, "length": 199, "protein_name": "DnaJ homolog subfamily C member 5B", "gene_name": "Dnajc5b", "organism": "Rat", "refseq_name": "dnaJ homolog subfamily C member 5B", "refseq_ac": [ { "id": "NP_001102650", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102650", "type": "external" } ], "gene_names_uniprotkb": "Dnajc5b", "gene_names_refseq": "Dnajc5b; RGD1562486", "protein_names_uniprotkb": "DnaJ homolog subfamily C member 5B; CSP-beta; Cysteine string protein beta", "protein_names_refseq": "CSP-beta; DnaJ (Hsp40) homolog, subfamily C, member 5 beta; cysteine string protein beta; dnaJ homolog subfamily C member 5B", "tax_id": 10116, "disease": "neuronal ceroid lipofuscinosis 4 (Disease Ontology:DOID:0110720); neuronal ceroid lipofuscinosis (Disease Ontology:DOID:14503)", "pathway": " (rno:499579)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0030658 transport vesicle membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZD82-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZTV3-1", "uniprot_id": [ { "id": "FLRT2_RAT", "url": "https://www.uniprot.org/uniprot/D3ZTV3", "type": "external" } ], "mass": 73874.0, "length": 660, "protein_name": "Leucine-rich repeat transmembrane protein FLRT2", "gene_name": "Flrt2", "organism": "Rat", "refseq_name": "leucine-rich repeat transmembrane protein FLRT2 precursor", "refseq_ac": [ { "id": "NP_001100220", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100220", "type": "external" } ], "gene_names_uniprotkb": "Flrt2", "gene_names_refseq": "Flrt2", "protein_names_uniprotkb": "Leucine-rich repeat transmembrane protein FLRT2; Fibronectin-like domain-containing leucine-rich transmembrane protein 2", "protein_names_refseq": "fibronectin-like domain-containing leucine-rich transmembrane protein 2; leucine-rich repeat transmembrane protein FLRT2 precursor; leucine-rich repeat transmembrane protein FLRT2", "tax_id": 10116, "disease": "", "pathway": " (rno:299236); (R-RNO-5654687)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22405201;38587072", "class_list": "", "function": "FLRT2 prevents endothelial cell senescence and vascular aging by regulating the ITGB4/mTORC2/p53 signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal organization of the cardiac basement membrane during embryogenesis, and for normal embryonic epicardium and heart morphogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0045499 chemorepellent activity;GO:0005104 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005925 focal adhesion", "go_biological_process": "GO:0003007 heart morphogenesis;GO:0051965 positive regulation of synapse assembly;GO:0007411 axon guidance;GO:2001222 regulation of neuron migration;GO:0008543 fibroblast growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZTV3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56558-1", "uniprot_id": [ { "id": "OGT1_RAT", "url": "https://www.uniprot.org/uniprot/P56558", "type": "external" } ], "mass": 115606.0, "length": 1036, "protein_name": "UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit", "gene_name": "Ogt", "organism": "Rat", "refseq_name": "UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform 1", "refseq_ac": [ { "id": "NP_058803", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058803", "type": "external" } ], "gene_names_uniprotkb": "Ogt", "gene_names_refseq": "Ogt", "protein_names_uniprotkb": "UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit; 2.4.1.255; O-GlcNAc transferase subunit p110; O-linked N-acetylglucosamine transferase 110 kDa subunit; OGT", "protein_names_refseq": "O linked N-acetylglucosamine transferase; O-GlcNAc transferase subunit p110; O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase); O-linked N-acetylglucosamine transferase 110 kDa subunit; UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform 1; UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit; UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase", "tax_id": 10116, "disease": "non-syndromic X-linked intellectual disability 106 (Disease Ontology:DOID:0080240); aortic valve stenosis (Disease Ontology:DOID:1712); congenital disorder of glycosylation (Disease Ontology:DOID:5212); congestive heart failure (Disease Ontology:DOID:6000); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:26295); (R-RNO-3214847); (R-RNO-5675482); (R-RNO-5689603); (R-RNO-9772755)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "10542233;10580430;11700029;1533623;16714295;18288188;18683930;24995978;38843836;9083067", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc) (PubMed:10542233, PubMed:24995978). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, AMPK, ATG4B, CAPRIN1, EZH2, FNIP1, GSDMD, KRT7, LMNA, LMNB1, LMNB2, RPTOR, HOXA1, PFKL, KMT2E/MLL5, MAPT/TAU, TET2, RBL2, RET, NOD2 and HCFC1 (PubMed:10542233). Can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing (By similarity). Involved in insulin resistance in muscle and adipocyte cells via glycosylating insulin signaling components and inhibiting the 'Thr-308' phosphorylation of AKT1, enhancing IRS1 phosphorylation and attenuating insulin signaling (PubMed:18288188). Involved in glycolysis regulation by mediating glycosylation of 6-phosphofructokinase PFKL, inhibiting its activity (By similarity). Plays a key role in chromatin structure by mediating O-GlcNAcylation of 'Ser-112' of histone H2B: recruited to CpG-rich transcription start sites of active genes via its interaction with TET proteins (TET1, TET2 or TET3) (By similarity). As part of the NSL complex indirectly involved in acetylation of nucleosomal histone H4 on several lysine residues (By similarity). O-GlcNAcylation of 'Ser-75' of EZH2 increases its stability, and facilitating the formation of H3K27me3 by the PRC2/EED-EZH2 complex (By similarity). Stabilizes KMT2E/MLL5 by mediating its glycosylation, thereby preventing KMT2E/MLL5 ubiquitination (By similarity). Regulates circadian oscillation of the clock genes and glucose homeostasis in the liver (By similarity). Stabilizes clock proteins BMAL1 and CLOCK through O-glycosylation, which prevents their ubiquitination and subsequent degradation (By similarity). Promotes the CLOCK-BMAL1-mediated transcription of genes in the negative loop of the circadian clock such as PER1/2 and CRY1/2 (By similarity). O-glycosylates HCFC1 and regulates its proteolytic processing and transcriptional activity (By similarity). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (By similarity). Regulates mitochondrial motility in neurons by mediating glycosylation of TRAK1 (PubMed:24995978). Promotes autophagy by mediating O-glycosylation of ATG4B (By similarity). Acts as a regulator of mTORC1 signaling by mediating O-glycosylation of RPTOR and FNIP1: O-GlcNAcylation of RPTOR in response to glucose sufficiency promotes activation of the mTORC1 complex (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, UniProtKB]; Purification of a glycosylated protein p135, and it's identification as a O-GlcNAc transferase, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 11, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.4.1.255", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.255", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0097363 protein O-acetylglucosaminyltransferase activity;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0042588 zymogen granule;GO:0098982 GABA-ergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0001934 positive regulation of protein phosphorylation;GO:0006110 regulation of glycolytic process;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 5, "hit_score": 1.3, "record_id": "P56558-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0100000001001.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K4R8-1", "uniprot_id": [ { "id": "NPT2C_RAT", "url": "https://www.uniprot.org/uniprot/Q8K4R8", "type": "external" } ], "mass": 63846.0, "length": 601, "protein_name": "Sodium-dependent phosphate transport protein 2C", "gene_name": "Slc34a3", "organism": "Rat", "refseq_name": "sodium-dependent phosphate transport protein 2C", "refseq_ac": [ { "id": "NP_647554", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647554", "type": "external" } ], "gene_names_uniprotkb": "Slc34a3", "gene_names_refseq": "Slc34a3", "protein_names_uniprotkb": "Sodium-dependent phosphate transport protein 2C; Na(+)-dependent phosphate cotransporter 2C; Na(+)/Pi cotransporter 2C; NaPi-2c; Sodium-phosphate transport protein 2C; Sodium/phosphate cotransporter 2C; Solute carrier family 34 member 3", "protein_names_refseq": "Na(+)-dependent phosphate cotransporter 2C; Na(+)/Pi cotransporter 2C; Na+/Pi-cotransporter type IIc; naPi-2c; sodium-dependent phosphate transport protein 2C; sodium-phosphate transport protein 2C; sodium/phosphate cotransporter 2C; solute carrier family 34 (sodium phosphate), member 3; solute carrier family 34 (type II sodium/phosphate contransporter), member 3; solute carrier family 34 (type II sodium/phosphate cotransporter), member 3", "tax_id": 10116, "disease": "hereditary hypophosphatemic rickets with hypercalciuria (Disease Ontology:DOID:0050947)", "pathway": " (rno:246234); (R-RNO-427589)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11880379;19493963;19841935;20526720;22673903;23816829", "class_list": "", "function": "Differential regulation of the renal sodium-phosphate cotransporters NaPi-IIa, NaPi-IIc, and PiT-2 in dietary potassium deficiency., [RefSeq, PubMed]; Expression in renal brush border not reduced by parathyroid hormones, [RefSeq, PubMed]; Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane (PubMed:11880379). The cotransport has a Na(+):Pi stoichiometry of 2:1 and is electroneutral (By similarity)., [UniProtKB, PubMed, UniProtKB]; Magnesium deficiency induces downregulation of 1alpha(OH)ase and type IIa and IIc Na/Pi cotransporters, and upregulation of 24(OH)ase in the kidney., [RefSeq, PubMed]; Results describe the regulation of the sodium/phosphate cotransporters SCL34A3 and SLC20A2 during phosphate deprivation and acidosis in rat kidney., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005436 sodium:phosphate symporter activity", "go_cellular_component": "GO:0005903 brush border;GO:0016324 apical plasma membrane;GO:0031982 vesicle;GO:0031526 brush border membrane", "go_biological_process": "GO:0031667 response to nutrient levels;GO:0006814 sodium ion transport;GO:0006817 phosphate ion transport;GO:0032026 response to magnesium ion;GO:0030643 intracellular phosphate ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8K4R8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35260-1", "uniprot_id": [ { "id": "NACC1_RAT", "url": "https://www.uniprot.org/uniprot/O35260", "type": "external" } ], "mass": 56450.0, "length": 514, "protein_name": "Nucleus accumbens-associated protein 1", "gene_name": "Nacc1", "organism": "Rat", "refseq_name": "nucleus accumbens-associated protein 1", "refseq_ac": [ { "id": "NP_599240", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599240", "type": "external" } ], "gene_names_uniprotkb": "Nacc1; Btbd14b; Nac1", "gene_names_refseq": "Btbd14b; Nac-1; Nac1; Nacc1", "protein_names_uniprotkb": "Nucleus accumbens-associated protein 1; BTB/POZ domain-containing protein 14B; NAC-1", "protein_names_refseq": "BTB (POZ) domain containing 14B; BTB/POZ domain-containing protein 14B; nucleus accumbens associated 1, BEN and BTB (POZ) domain containing; nucleus accumbens-1; nucleus accumbens-associated protein 1; transcriptional repressor NAC1", "tax_id": 10116, "disease": "", "pathway": " (rno:171454)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11906783;12725910;16033423;16045493;17254023;17699672;29393594;9278521", "class_list": "", "function": "Aberrantly regulated NAC1 expression in the mammalian brain may contribute to programmed cell death, [RefSeq, PubMed]; Functions as a transcriptional repressor. Isoform 1 is a stronger transcriptional repressor than isoform 2. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; The two isoforms of NAC-1 may differentially affect neuronal functions, including the regulation of cocaine-induced locomotion. The longer isoform was the more abundant of the two NAC1 proteins and the ratio between them differed throughout the rat brain., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O35260-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08516-1", "uniprot_id": [ { "id": "CP4AA_RAT", "url": "https://www.uniprot.org/uniprot/P08516", "type": "external" } ], "mass": 58215.0, "length": 509, "protein_name": "Cytochrome P450 4A10", "gene_name": "Cyp4a10", "organism": "Rat", "refseq_name": "cytochrome P450 4A10", "refseq_ac": [ { "id": "NP_787031", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_787031", "type": "external" } ], "gene_names_uniprotkb": "Cyp4a10; Cyp4a-1; Cyp4a1", "gene_names_refseq": "CYPIVA10; Cyp4a10; Cyp4a1; Cyp4a22", "protein_names_uniprotkb": "Cytochrome P450 4A10; 1.14.14.80; CYPIVA10; Cytochrome P450-LA-omega 1; Cytochrome P452; Lauric acid omega-hydroxylase; Long-chain fatty acid omega-monooxygenase", "protein_names_refseq": "cytochrome P450 4A10; cytochrome P450, 4A1; cytochrome P450, 4a10; cytochrome P450, IVA1; cytochrome P450, family 4, subfamily A, polypeptide 22; cytochrome P450, family 4, subfamily a, polypeptide 10; cytochrome P450-LA-omega 1; cytochrome P452; lauric acid omega-hydroxylase; long-chain fatty acid omega-monooxygenase", "tax_id": 10116, "disease": "autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); hypertension (Disease Ontology:DOID:10763)", "pathway": " (rno:50549); (R-RNO-211935); (R-RNO-211958); (R-RNO-211979); (R-RNO-2142691)", "pathway_count": 5, "publication_count": 15, "publication_id_list": "10362749;10620324;11139583;11821421;14742258;1567203;16212878;22938512;25540098;25636742;27537772;2766932;30227249;3027069;3410047", "class_list": "", "function": "A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of long-chain fatty acids (PubMed:10362749, PubMed:10620324, PubMed:3027069). Acts as a major omega-hydroxylase for dodecanoic (lauric) acid in liver (PubMed:3027069). In kidney, may play an important role in omega-hydroxylation of (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) to 20-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure (PubMed:10362749, PubMed:10620324, PubMed:16212878). Also participates in the formation of anti-inflammatory hydroxyepoxyeicosatrienoic acids (HEETs) in kidney by converting 8,9-epoxyeicosatrienoic acid (EET) to 20,8,9-HEET, an activator of PPARA (PubMed:14742258). Displays substantially lower fatty acid omega-1 hydroxylase activity (PubMed:10362749, PubMed:10620324). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:10362749, PubMed:10620324, PubMed:3027069)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; In CYP4A1 transgenic Dahl salt-sensitive rat formation of 20-HETE in the cerebral vasculature was elevated rescuing impaired myogenic response/autoregulation of cerebrovascular blood flow., [RefSeq, PubMed]; Rosuvastatin downregulates CYP4A1 in spontaneously hypertensive rats, [RefSeq, PubMed]; Salt sensitive rats have an up-regulation of the CYP4A/20-HETE pathway resulting in elevated reactive oxygen species and reduced NO bioavailability causing vascular dysfunction., [RefSeq, PubMed]; The CYP4A pathway plays a role in vascular dysfunction in SS rats and there appears to be a direct role of reduced NO availability due to salt-induced oxidant stress in upregulating CYP4A enzyme expression., [RefSeq, PubMed]; These results indicated that AngII chronically increased the CYP4A isoform expression in the rat kidney. The AngII-induced CYP4A isoform expression was mediated by AT1-R., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5EBD8", "ec_number_list": [ { "id": "1.14.14.80", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.80", "type": "external" }, { "id": "1.14.14.79", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.79", "type": "external" }, { "id": "1.14.13.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.n7", "type": "external" }, { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" }, { "id": "1.14.14.94", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.94", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0103002 16-hydroxypalmitate dehydrogenase activity;GO:0018685 alkane 1-monooxygenase activity;GO:0008391 arachidonate monooxygenase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0002933 lipid hydroxylation;GO:0046456 icosanoid biosynthetic process;GO:0001822 kidney development;GO:0043651 linoleic acid metabolic process;GO:0001890 placenta development", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P08516-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19225-1", "uniprot_id": [ { "id": "CP270_RAT", "url": "https://www.uniprot.org/uniprot/P19225", "type": "external" } ], "mass": 56157.0, "length": 489, "protein_name": "Cytochrome P450 2C70", "gene_name": "Cyp2c22; Cyp2c70", "organism": "Rat", "refseq_name": "cytochrome P450 2C70 precursor", "refseq_ac": [ { "id": "NP_612521", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612521", "type": "external" } ], "gene_names_uniprotkb": "Cyp2c22; Cyp2c70; Cyp2c-70; Cyp2c22; P450md", "gene_names_refseq": "CYPIIC70; Cyp2c22; Cyp2c70; P-450Md", "protein_names_uniprotkb": "Cytochrome P450 2C70; 1.14.14.-; CYPIIC70; Cytochrome P-450Md; Cytochrome P450 P49", "protein_names_refseq": "cytochrome P-450Md; cytochrome P450 2C70 precursor; cytochrome P450 2C70; cytochrome P450 2c22; cytochrome P450 P49; cytochrome P450, family 2, subfamily c, polypeptide 70", "tax_id": 10116, "disease": "", "pathway": " (rno:171518)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "20147703;2263625;2395662;24144795", "class_list": "", "function": "A cytochrome P450 monooxygenase involved in muricholic acid (MCA) synthesis. Hydroxylates at the 6-beta position two major bile acids, chenodeoxycholic acid (CDCA) and ursodeoxycholic acid (UDCA) to form alpha-MCA and beta-MCA, respectively. May regulate NR1H4/farnesoid X receptor signaling, as taurine-conjugated MCAs are antagonists of NR1H4. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase)., [UniProtKB, UniProtKB]; CYP2C22 protein is rapidly downregulated in primary rat hepatocytes by interleukin(IL)-1beta or nitric oxide-donating compounds., [RefSeq, PubMed]; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics., [UniProtKB, UniProtKB]; Data demonstrate that CYP2C22 is a high-abundance, retinoid-inducible, hepatic P450 with the potential to metabolize at-RA, providing additional insight into the role of the CYP2C gene family in retinoid homeostasis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.14.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.-", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0004497 monooxygenase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0043231 intracellular membrane-bounded organelle;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0042178 xenobiotic catabolic process;GO:0019373 epoxygenase P450 pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P19225-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43253-1", "uniprot_id": [ { "id": "PI2R_RAT", "url": "https://www.uniprot.org/uniprot/P43253", "type": "external" } ], "mass": 44662.0, "length": 416, "protein_name": "Prostacyclin receptor", "gene_name": "Ptgir", "organism": "Rat", "refseq_name": "prostacyclin receptor", "refseq_ac": [ { "id": "NP_001071112", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071112", "type": "external" } ], "gene_names_uniprotkb": "Ptgir", "gene_names_refseq": "Ptgir", "protein_names_uniprotkb": "Prostacyclin receptor; PGI receptor; PGI2 receptor; Prostaglandin I2 receptor; Prostanoid IP receptor", "protein_names_refseq": "PGI receptor; PGI2 receptor; prostacyclin receptor; prostaglandin I receptor (IP); prostaglandin I2 (prostacyclin) receptor (IP); prostanoid IP receptor", "tax_id": 10116, "disease": "", "pathway": " (rno:292661); (R-RNO-391908); (R-RNO-392851)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "22673903;7803522", "class_list": "", "function": "Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016501 prostacyclin receptor activity;GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0032496 response to lipopolysaccharide;GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P43253-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P80254-1", "uniprot_id": [ { "id": "DOPD_RAT", "url": "https://www.uniprot.org/uniprot/P80254", "type": "external" } ], "mass": 13133.0, "length": 118, "protein_name": "D-dopachrome decarboxylase", "gene_name": "Ddt", "organism": "Rat", "refseq_name": "D-dopachrome decarboxylase", "refseq_ac": [ { "id": "NP_077045", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077045", "type": "external" } ], "gene_names_uniprotkb": "Ddt", "gene_names_refseq": "Ddt", "protein_names_uniprotkb": "D-dopachrome decarboxylase; 4.1.1.84; D-dopachrome tautomerase", "protein_names_refseq": "D-dopachrome decarboxylase; dopachrome isomerase", "tax_id": 10116, "disease": "", "pathway": " (rno:29318)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "22673903;34116703;7589466;8267597", "class_list": "", "function": "D-dopachrome tautomerase activates COX2/PGE2 pathway of astrocytes to mediate inflammation following spinal cord injury. Publication Status: Online-Only, [RefSeq, PubMed]; Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.1.1.84", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.84", "type": "external" } ], "go_molecular_function": "GO:0002020 protease binding;GO:0005126 cytokine receptor binding;GO:0004167 dopachrome isomerase activity;GO:0033981 D-dopachrome decarboxylase activity;GO:0050178 phenylpyruvate tautomerase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0050729 positive regulation of inflammatory response;GO:0032760 positive regulation of tumor necrosis factor production;GO:0042438 melanin biosynthetic process;GO:0010760 negative regulation of macrophage chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P80254-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06000-1", "uniprot_id": [ { "id": "LIPL_RAT", "url": "https://www.uniprot.org/uniprot/Q06000", "type": "external" } ], "mass": 53082.0, "length": 474, "protein_name": "Lipoprotein lipase", "gene_name": "Lpl", "organism": "Rat", "refseq_name": "lipoprotein lipase precursor", "refseq_ac": [ { "id": "NP_036730", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036730", "type": "external" } ], "gene_names_uniprotkb": "Lpl", "gene_names_refseq": "Lpl", "protein_names_uniprotkb": "Lipoprotein lipase; 3.1.1.32; 3.1.1.34; LPL; Phospholipase A1", "protein_names_refseq": "lipoprotein lipase precursor; phospholipase A1", "tax_id": 10116, "disease": "alcohol-associated liver disease (Disease Ontology:DOID:0070658); muscular disease (Disease Ontology:DOID:0080000); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); familial hyperlipidemia (Disease Ontology:DOID:1168); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); familial combined hyperlipidemia (Disease Ontology:DOID:13809); familial lipoprotein lipase deficiency (Disease Ontology:DOID:14118); abdominal obesity-metabolic syndrome 1 (Disease Ontology:DOID:14221); coronary artery disease (Disease Ontology:DOID:3393); myocardial infarction (Disease Ontology:DOID:5844); end stage renal disease (Disease Ontology:DOID:783); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24539); (R-RNO-8963889); (R-RNO-8963901); (R-RNO-975634)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "1339374;19527804;19715756;2233752;30660685;31108749;38114521", "class_list": "", "function": "Data indicate that long noncoding RNA (lncRNA-MIAT) suppressed lipoprotein lipase (LPL) by increasing miR-328a-5p, thereby inhibiting vascular endothelial cells (VECs) injury to attenuate erectile dysfunction (ED) in diabetic rats., [RefSeq, PubMed]; Developing a model to predict the early risk of hypertriglyceridemia based on inhibiting lipoprotein lipase (LPL): a translational study. Publication Status: Online-Only, [RefSeq, PubMed]; Key enzyme in triglyceride metabolism (By similarity). Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage (By similarity). Although it has both phospholipase and triglyceride lipase activities it is primarily a triglyceride lipase with low but detectable phospholipase activity (By similarity). Mediates margination of triglyceride-rich lipoprotein particles in capillaries (By similarity). Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans (By similarity)., [UniProtKB, UniProtKB]; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans., [UniProtKB, UniProtKB]; Tibet kefir milk decreases fat deposition by regulating the gut microbiota and gene expression of Lpl and Angptl4 in high fat diet-fed rats., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.116", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.116", "type": "external" }, { "id": "3.4.21.75", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.75", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.1.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.26", "type": "external" }, { "id": "3.1.1.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.34", "type": "external" } ], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0008201 heparin binding;GO:0034185 apolipoprotein binding;GO:0042803 protein homodimerization activity;GO:0043395 heparan sulfate proteoglycan binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0034361 very-low-density lipoprotein particle", "go_biological_process": "GO:0031670 cellular response to nutrient;GO:1904179 positive regulation of adipose tissue development;GO:0001523 retinoid metabolic process;GO:0006631 fatty acid metabolic process;GO:0006641 triglyceride metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q06000-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q09128-1", "uniprot_id": [ { "id": "CP24A_RAT", "url": "https://www.uniprot.org/uniprot/Q09128", "type": "external" } ], "mass": 59448.0, "length": 514, "protein_name": "1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial", "gene_name": "Cyp24a1", "organism": "Rat", "refseq_name": "1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_963966", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_963966", "type": "external" } ], "gene_names_uniprotkb": "Cyp24a1; Cyp24", "gene_names_refseq": "24-OHase; 24R-Ohase; Cyp24a1; Cyp24; P450-CC24; VITD12", "protein_names_uniprotkb": "1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial; 1.14.15.16; 24-OHase; Cytochrome P450 24A1; Cytochrome P450-CC24; Vitamin D(3) 24-hydroxylase", "protein_names_refseq": "1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial precursor; 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial; 25-hydroxyvitamin D3 24-hydroxylase; 25-hydroxyvitaminD324-hydroxylase; Cytochrom P450 (25-hydroxyvitamin D24-hydroxylase); cytochrome P450 24A1; cytochrome P450, subfamily 24; cytochrome P450-CC24; vitamin D(3) 24-hydroxylase", "tax_id": 10116, "disease": "colorectal adenoma (Disease Ontology:DOID:0050860); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); infantile hypercalcemia 1 (Disease Ontology:DOID:0061136); pre-eclampsia (Disease Ontology:DOID:10591); gestational diabetes (Disease Ontology:DOID:11714); lung cancer (Disease Ontology:DOID:1324); rectum cancer (Disease Ontology:DOID:1993); colon cancer (Disease Ontology:DOID:219); colon adenocarcinoma (Disease Ontology:DOID:234); asthma (Disease Ontology:DOID:2841); breast carcinoma (Disease Ontology:DOID:3459); ovary adenocarcinoma (Disease Ontology:DOID:3713); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung carcinoma (Disease Ontology:DOID:3905); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); esophagus adenocarcinoma (Disease Ontology:DOID:4914); esophageal cancer (Disease Ontology:DOID:5041); lung small cell carcinoma (Disease Ontology:DOID:5409); ulcerative colitis (Disease Ontology:DOID:8577); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:25279); (R-RNO-196791); (R-RNO-211916)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10231362;15574355;16617161;1991512;19961857;2026586;25727742;33596463;8036172;8418863", "class_list": "", "function": "A cytochrome P450 monooxygenase with a key role in vitamin D catabolism and calcium homeostasis. Via C24-oxidation pathway, catalyzes the inactivation of both the vitamin D precursor calcidiol (25-hydroxyvitamin D(3)) and the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D(3)) (PubMed:10231362, PubMed:16617161, PubMed:2026586). With initial hydroxylation at C-24 (via C24-oxidation pathway), performs a sequential 6-step oxidation of calcitriol leading to the formation of the biliary metabolite calcitroic acid (PubMed:10231362, PubMed:16617161). Hydroxylates at C-24 or C-25 other vitamin D active metabolites, such as CYP11A1-derived secosteroids 20S-hydroxycholecalciferol and 20S,23-dihydroxycholecalciferol (PubMed:25727742). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via FDXR/adrenodoxin reductase and FDX1/adrenodoxin (PubMed:2026586)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Altered expression of the vitamin D metabolizing enzymes CYP27B1 and CYP24A1 under the context of prostate aging and pathologies., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 22, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q498V4;Q63685", "ec_number_list": [ { "id": "1.14.15.16", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.15.16", "type": "external" } ], "go_molecular_function": "GO:0008403 25-hydroxycholecalciferol-24-hydroxylase activity;GO:0030342 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity;GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0030343 vitamin D3 25-hydroxylase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0042359 vitamin D metabolic process;GO:0042369 vitamin D catabolic process;GO:0001649 osteoblast differentiation;GO:0033280 response to vitamin D;GO:0071305 cellular response to vitamin D", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q09128-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3KR64-1", "uniprot_id": [ { "id": "CX049_RAT", "url": "https://www.uniprot.org/uniprot/Q3KR64", "type": "external" } ], "mass": 54948.0, "length": 510, "protein_name": "Uncharacterized protein CXorf49 homolog", "gene_name": "", "organism": "Rat", "refseq_name": "uncharacterized protein CXorf49 homolog", "refseq_ac": [ { "id": "NP_001138613", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138613", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "4933412E24Rikl", "protein_names_uniprotkb": "Uncharacterized protein CXorf49 homolog", "protein_names_refseq": "uncharacterized protein CXorf49 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:500876)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3KR64-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V7C8-1", "uniprot_id": [ { "id": "CEP55_RAT", "url": "https://www.uniprot.org/uniprot/Q4V7C8", "type": "external" } ], "mass": 53995.0, "length": 462, "protein_name": "Centrosomal protein of 55 kDa", "gene_name": "Cep55", "organism": "Rat", "refseq_name": "centrosomal protein of 55 kDa", "refseq_ac": [ { "id": "NP_001020817", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020817", "type": "external" } ], "gene_names_uniprotkb": "Cep55", "gene_names_refseq": "Cep55; RGD1305340", "protein_names_uniprotkb": "Centrosomal protein of 55 kDa; Cep55", "protein_names_refseq": "centrosomal protein 55kDa; centrosomal protein of 55 kDa", "tax_id": 10116, "disease": "Meckel syndrome (Disease Ontology:DOID:0050778); multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia and hydranencephaly (Disease Ontology:DOID:0080327); hydranencephaly (Disease Ontology:DOID:4626)", "pathway": " (rno:294074)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;25449601", "class_list": "", "function": "Plays a role in mitotic exit and cytokinesis. Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Required for successful completion of cytokinesis. Not required for microtubule nucleation. Plays a role in the development of the brain and kidney., [UniProtKB, UniProtKB]; Upregulation of Cep55 in the rostral ventrolateral medulla elicits impairment of brain stem cardiovascular regulation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005829 cytosol;GO:0045171 intercellular bridge;GO:0032154 cleavage furrow;GO:0005814 centriole", "go_biological_process": "GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:1904888 cranial skeletal system development;GO:0045184 establishment of protein localization;GO:0000281 mitotic cytokinesis;GO:0061952 midbody abscission", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4V7C8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5I0E3-1", "uniprot_id": [ { "id": "CHOLN_RAT", "url": "https://www.uniprot.org/uniprot/Q5I0E3", "type": "external" } ], "mass": 22126.0, "length": 193, "protein_name": "Cholesin", "gene_name": "Chlsn", "organism": "Rat", "refseq_name": "cholesin", "refseq_ac": [ { "id": "NP_001020204", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020204", "type": "external" } ], "gene_names_uniprotkb": "Chlsn; LOC498154", "gene_names_refseq": "C12h7orf50; C7orf50; Chlsn", "protein_names_uniprotkb": "Cholesin; Protein C7orf50 homolog", "protein_names_refseq": "cholesin; uncharacterized protein C7orf50 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:498154)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Hormone secreted from the intestine in response to cholesterol, where it acts to inhibit cholesterol synthesis in the liver and VLDL secretion,leading to a reduction in circulating cholesterol levels. Acts through binding to its receptor, GPR146., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0045541 negative regulation of cholesterol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5I0E3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62658-1", "uniprot_id": [ { "id": "FKB1A_RAT", "url": "https://www.uniprot.org/uniprot/Q62658", "type": "external" } ], "mass": 11923.0, "length": 108, "protein_name": "Peptidyl-prolyl cis-trans isomerase FKBP1A", "gene_name": "Fkbp1a", "organism": "Rat", "refseq_name": "peptidyl-prolyl cis-trans isomerase FKBP1A", "refseq_ac": [ { "id": "NP_037234", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037234", "type": "external" } ], "gene_names_uniprotkb": "Fkbp1a; Fkbp1", "gene_names_refseq": "FKBP12; Fkbp1a; Fkbp2", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase FKBP1A; 12 kDa FK506-binding protein; 12 kDa FKBP; 5.2.1.8; FK506-binding protein 1A; FKBP-12; FKBP-1A; Immunophilin FKBP12; PPIase FKBP1A; Rotamase", "protein_names_refseq": "12 kDa FK506-binding protein; 12 kDa FKBP; FK506 binding protein 1a; FK506 binding protein 2 (13 kDa); FK506-binding protein 1 (12kD); FK506-binding protein 1A; FKBP-12; FKBP-1A; PPIase FKBP1A; immunophilin FKBP12; peptidyl-prolyl cis-trans isomerase FKBP1A; rotamase", "tax_id": 10116, "disease": "Barth syndrome (Disease Ontology:DOID:0050476); Parkinsonism (Disease Ontology:DOID:0080855)", "pathway": " (rno:25639); (R-RNO-166208); (R-RNO-2025928); (R-RNO-2173789)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "20431056;22673903;29229832;7518616;9013543", "class_list": "", "function": "FKBP12 can endogenously regulate calcineurin activity with therapeutic implications for the treatment of Parkinson's Disease., [RefSeq, PubMed]; Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0JN04;P97533", "ec_number_list": [ { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.7.11.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.30", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" } ], "go_molecular_function": "GO:0030547 signaling receptor inhibitor activity;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0005246 calcium channel regulator activity;GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0043679 axon terminus;GO:0045202 synapse", "go_biological_process": "GO:0006936 muscle contraction;GO:1990000 amyloid fibril formation;GO:0031000 response to caffeine;GO:1902991 regulation of amyloid precursor protein catabolic process;GO:0050776 regulation of immune response", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q62658-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63362-1", "uniprot_id": [ { "id": "NDUA5_RAT", "url": "https://www.uniprot.org/uniprot/Q63362", "type": "external" } ], "mass": 13412.0, "length": 116, "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5", "gene_name": "Ndufa5", "organism": "Rat", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5", "refseq_ac": [ { "id": "NP_037117", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037117", "type": "external" } ], "gene_names_uniprotkb": "Ndufa5", "gene_names_refseq": "NADHUO; Ndufa5", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5; CI-13kD-B; Complex I subunit B13; Complex I-13kD-B; NADH-ubiquinone oxidoreductase 13 kDa-B subunit", "protein_names_refseq": "CI-13kD-B; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5; NADH ubiquinone oxidoreductase subunit B13; NADH-ubiquinone oxidoreductase 13 kDa-B subunit; complex I subunit B13; complex I-13kD-B", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (rno:25488); (R-RNO-611105); (R-RNO-6799198); (R-RNO-9013408)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "15047621;22673903;8875451", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Inhibition of this enzyme by antidiabetics such as metformin may contribute to the understanding of antidiabetic actions., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0032991 protein-containing complex;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0022904 respiratory electron transport chain", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q63362-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JM80-1", "uniprot_id": [ { "id": "PHAG1_RAT", "url": "https://www.uniprot.org/uniprot/Q9JM80", "type": "external" } ], "mass": 45915.0, "length": 424, "protein_name": "Phosphoprotein associated with glycosphingolipid-enriched microdomains 1", "gene_name": "Pag1", "organism": "Rat", "refseq_name": "phosphoprotein associated with glycosphingolipid-enriched microdomains 1", "refseq_ac": [ { "id": "NP_071589", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071589", "type": "external" } ], "gene_names_uniprotkb": "Pag1; Cbp; Pag", "gene_names_refseq": "Cbp; Pag1", "protein_names_uniprotkb": "Phosphoprotein associated with glycosphingolipid-enriched microdomains 1; Csk-binding protein; Transmembrane phosphoprotein Cbp", "protein_names_refseq": "Csk binding protein; csk-binding protein; phosphoprotein associated with glycosphingolipid microdomains 1; phosphoprotein associated with glycosphingolipid-enriched microdomains 1; transmembrane phosphoprotein Cbp", "tax_id": 10116, "disease": "", "pathway": " (rno:64019); (R-RNO-180292); (R-RNO-202427)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10801129;10918051;11859092;14613929;15890337;16920712;22673903;23035659;23548896", "class_list": "", "function": "An allosteric connection between Cbp binding and Csk activation that arises from residues in the betaB/betaC loop of the SH2 domain., [RefSeq, PubMed]; Csk negatively regulates growth factor induced neural differentiation and augments Akt kinase activity., [RefSeq, PubMed]; Negative feedback regulator of mast cell signaling through the FcepsilonRI, [RefSeq, PubMed]; Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042169 SH2 domain binding;GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045121 membrane raft", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0002250 adaptive immune response;GO:0050868 negative regulation of T cell activation;GO:0050863 regulation of T cell activation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9JM80-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZHV2-1", "uniprot_id": [ { "id": "MACF1_RAT", "url": "https://www.uniprot.org/uniprot/D3ZHV2", "type": "external" } ], "mass": 619600.0, "length": 5430, "protein_name": "Microtubule-actin cross-linking factor 1", "gene_name": "Macf1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Macf1; Acf7; Aclp7; Macf", "gene_names_refseq": "", "protein_names_uniprotkb": "Microtubule-actin cross-linking factor 1; Actin cross-linking family 7", "protein_names_refseq": "", "tax_id": 10116, "disease": "lissencephaly 9 with complex brainstem malformation (Disease Ontology:DOID:0112228); cancer (Disease Ontology:DOID:162)", "pathway": "", "pathway_count": 0, "publication_count": 5, "publication_id_list": "16641100;16815997;22673903;29393594;38843836", "class_list": "", "function": "F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (By similarity). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (By similarity). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (By similarity). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0008017 microtubule binding;GO:0051015 actin filament binding;GO:0016887 ATP hydrolysis activity;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005874 microtubule;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane;GO:0051893 regulation of focal adhesion assembly;GO:0016477 cell migration;GO:0016055 Wnt signaling pathway;GO:0030334 regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "D3ZHV2-1", "record_type": "protein", "filter_code": "0000000.0000110.000100.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4L1J4-1", "uniprot_id": [ { "id": "MAGI1_RAT", "url": "https://www.uniprot.org/uniprot/Q4L1J4", "type": "external" } ], "mass": 136327.0, "length": 1255, "protein_name": "Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1", "gene_name": "Magi1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Magi1; Baiap1; Bap1", "gene_names_refseq": "", "protein_names_uniprotkb": "Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1; BAI1-associated protein 1; BAP-1; MAGI-1; Membrane-associated guanylate kinase inverted 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:500261)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16155592;16751601;22673903", "class_list": "", "function": "Plays a role in coupling actin fibers to cell junctions in endothelial cells, via its interaction with AMOTL2 and CDH5 (By similarity). May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4L1J5", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0051393 alpha-actinin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005912 adherens junction", "go_biological_process": "GO:0022409 positive regulation of cell-cell adhesion;GO:0007165 signal transduction;GO:0001886 endothelial cell morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q4L1J4-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08873-1", "uniprot_id": [ { "id": "MADD_RAT", "url": "https://www.uniprot.org/uniprot/O08873", "type": "external" } ], "mass": 177992.0, "length": 1602, "protein_name": "MAP kinase-activating death domain protein", "gene_name": "Madd", "organism": "Rat", "refseq_name": "MAP kinase-activating death domain protein isoform 1", "refseq_ac": [ { "id": "NP_446037", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446037", "type": "external" } ], "gene_names_uniprotkb": "Madd", "gene_names_refseq": "Madd; RabGEF; RabGEP", "protein_names_uniprotkb": "MAP kinase-activating death domain protein; Rab3 GDP/GTP exchange factor; Rab3 GDP/GTP exchange protein; RabGEF; RabGEP", "protein_names_refseq": "MAP kinase-activating death domain protein isoform 1; MAP kinase-activating death domain protein; Rab3 GDP/GTP exchange protein; rab3 GDP/GTP exchange factor", "tax_id": 10116, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); transient cerebral ischemia (Disease Ontology:DOID:224); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:94193); (R-RNO-5357905); (R-RNO-8876198)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "15007167;16641100;17496889;19322778;22673903;23702376;9020086", "class_list": "", "function": "Guanyl-nucleotide exchange factor that regulates small GTPases of the Rab family (PubMed:9020086). Converts GDP-bound inactive form of RAB27A and RAB27B to the GTP-bound active forms (By similarity). Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms, GTPases involved in synaptic vesicle exocytosis and vesicle secretion (PubMed:9020086). Plays a role in synaptic vesicle formation and in vesicle trafficking at the neuromuscular junction (By similarity). Involved in up-regulating a post-docking step of synaptic exocytosis in central synapses (By similarity). Probably by binding to the motor proteins KIF1B and KIF1A, mediates motor-dependent transport of GTP-RAB3A-positive vesicles to the presynaptic nerve terminals (By similarity). Plays a role in TNFA-mediated activation of the MAPK pathway, including ERK1/2 (By similarity). May link TNFRSF1A with MAP kinase activation (By similarity). May be involved in the regulation of TNFA-induced apoptosis (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Guanyl-nucleotide exchange factor that regulates small GTPases of the Rab family. Converts GDP-bound inactive form of RAB27A and RAB27B to the GTP-bound active forms. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms, GTPases involved in synaptic vesicle exocytosis and vesicle secretion. Plays a role in synaptic vesicle formation and in vesicle trafficking at the neuromuscular junction. Involved in up-regulating a post-docking step of synaptic exocytosis in central synapses. Probably by binding to the motor proteins KIF1B and KIF1A, mediates motor-dependent transport of GTP-RAB3A-positive vesicles to the presynaptic nerve terminals. Plays a role in TNFA-mediated activation of the MAPK pathway, including ERK1/2. May link TNFRSF1A with MAP kinase activation. May be involved in the regulation of TNFA-induced apoptosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These findings indicated that Madd functions as a guanine nucleotide exchange factor for Rab27 in parotid acinar cells and regulates isoproterenol-stimulated amylase release., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0045202 synapse;GO:1904115 axon cytoplasm", "go_biological_process": "GO:0032483 regulation of Rab protein signal transduction;GO:0060125 negative regulation of growth hormone secretion;GO:0043410 positive regulation of MAPK cascade;GO:0097194 execution phase of apoptosis;GO:2001236 regulation of extrinsic apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O08873-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QXN4-1", "uniprot_id": [ { "id": "MIOX_RAT", "url": "https://www.uniprot.org/uniprot/Q9QXN4", "type": "external" } ], "mass": 33185.0, "length": 285, "protein_name": "Inositol oxygenase", "gene_name": "Miox", "organism": "Rat", "refseq_name": "inositol oxygenase", "refseq_ac": [ { "id": "NP_665714", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665714", "type": "external" } ], "gene_names_uniprotkb": "Miox; Aldrl6; Ksp32; Rsor", "gene_names_refseq": "Aldrl6; Miox; RSOR", "protein_names_uniprotkb": "Inositol oxygenase; 1.13.99.1; Aldehyde reductase-like 6; Kidney-specific protein 32; MI oxygenase; Myo-inositol oxygenase; Renal-specific oxidoreductase", "protein_names_refseq": "MI oxygenase; aldehyde reductase (aldose reductase) like 6; aldehyde reductase-like 6; inositol oxygenase; kidney-specific protein 32; renal-specific oxido-reductase; renal-specific oxidoreductase", "tax_id": 10116, "disease": "", "pathway": " (rno:252899); (R-RNO-1855183)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10944187;15504367;19053028;22673903;26578517", "class_list": "", "function": "Data suggest that Miox expression/activity is up-regulated in kidneys tubules during oxidative stress (as in obesity and diabetic nephropathy); up-regulation of Miox activity is related to phosphorylation of serine/threonine residues., [RefSeq, PubMed]; Increased expression of MIOX in diabetic kidneys may contribute to tubulointerstitial injury and the development of diabetic nephropathy, [RefSeq, PubMed]; Molecular cloning and characterization of myo-inositol oxygenase as a 33kDa protein., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5S8C8;Q68G06;Q99PN7", "ec_number_list": [ { "id": "1.13.99.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.99.1", "type": "external" } ], "go_molecular_function": "GO:0008106 alcohol dehydrogenase (NADP+) activity;GO:0016651 oxidoreductase activity, acting on NAD(P)H;GO:0050661 NADP binding;GO:0008199 ferric iron binding;GO:0050113 inositol oxygenase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016234 inclusion body", "go_biological_process": "GO:0019310 inositol catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9QXN4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z311-1", "uniprot_id": [ { "id": "MECR_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z311", "type": "external" } ], "mass": 40327.0, "length": 373, "protein_name": "Enoyl-[acyl-carrier-protein] reductase, mitochondrial", "gene_name": "Mecr", "organism": "Rat", "refseq_name": "enoyl-[acyl-carrier-protein] reductase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_058905", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058905", "type": "external" } ], "gene_names_uniprotkb": "Mecr; Nrbf1", "gene_names_refseq": "Mecr; Nrbf1", "protein_names_uniprotkb": "Enoyl-[acyl-carrier-protein] reductase, mitochondrial; 1.3.1.104; 2-enoyl thioester reductase; NRBF-1; Nuclear receptor-binding factor 1", "protein_names_refseq": "2-enoyl thioester reductase; NRBF-1; enoyl-[acyl-carrier-protein] reductase, mitochondrial precursor; enoyl-[acyl-carrier-protein] reductase, mitochondrial; nuclear receptor-binding factor 1; trans-2-enoyl-CoA reductase, mitochondrial", "tax_id": 10116, "disease": "childhood-onset dystonia with optic atrophy and basal ganglia abnormalities (Disease Ontology:DOID:0081419); Leber hereditary optic neuropathy with demyelinating disease of CNS (Disease Ontology:DOID:0111756); optic atrophy (Disease Ontology:DOID:5723)", "pathway": " (rno:29470); (R-RNO-77346)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "12654921;25031892;9795230", "class_list": "", "function": "Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Displays a preference for medium-chain over short- and long-chain substrates (By similarity). May provide the octanoyl chain used for lipoic acid biosynthesis, regulating protein lipoylation and mitochondrial respiratory activity particularly in Purkinje cells (By similarity). Involved in iron homeostasis; affecting Fe-S cluster assembly and ceramide metabolism (By similarity). Required for proper morphology and bioenergetic functions of mitochondria (By similarity). Required for maintenance of neurons (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1LPY7", "ec_number_list": [ { "id": "1.1.1.100", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.100", "type": "external" }, { "id": "1.3.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.39", "type": "external" }, { "id": "2.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.38", "type": "external" }, { "id": "2.3.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.39", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "2.3.1.85", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.85", "type": "external" }, { "id": "3.1.2.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.14", "type": "external" }, { "id": "4.2.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.59", "type": "external" }, { "id": "1.3.1.104", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.104", "type": "external" } ], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0141148 enoyl-[acyl-carrier-protein] reductase (NADPH) activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0016020 membrane", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0046513 ceramide biosynthetic process;GO:0006633 fatty acid biosynthetic process;GO:0006879 intracellular iron ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9Z311-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4ABL6-1", "uniprot_id": [ { "id": "MCTP1_RAT", "url": "https://www.uniprot.org/uniprot/D4ABL6", "type": "external" } ], "mass": 106483.0, "length": 946, "protein_name": "Multiple C2 and transmembrane domain-containing protein 1", "gene_name": "Mctp1", "organism": "Rat", "refseq_name": "multiple C2 and transmembrane domain-containing protein 1", "refseq_ac": [ { "id": "NP_001363863", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001363863", "type": "external" } ], "gene_names_uniprotkb": "Mctp1", "gene_names_refseq": "Mctp1-ps1; Mctp1; RGD1305199", "protein_names_uniprotkb": "Multiple C2 and transmembrane domain-containing protein 1", "protein_names_refseq": "multiple C2 and transmembrane domain-containing protein 1; multiple C2 domains, transmembrane 1, pseudogene 1", "tax_id": 10116, "disease": "", "pathway": " (rno:309928)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "26195140", "class_list": "", "function": "Calcium sensor which is essential for the stabilization of normal baseline neurotransmitter release and for the induction and long-term maintenance of presynaptic homeostatic plasticity (By similarity). Overexpression in cultured neurons significantly inhibits neuronal transferrin endocytosis, secretory vesicle retrieval, cell migration, and oxidative stress from glutamate toxicity (PubMed:26195140)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A1W2Q6L3", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0016020 membrane;GO:0055037 recycling endosome;GO:0005789 endoplasmic reticulum membrane;GO:0030672 synaptic vesicle membrane", "go_biological_process": "GO:0045806 negative regulation of endocytosis;GO:0030336 negative regulation of cell migration;GO:0046928 regulation of neurotransmitter secretion;GO:0048168 regulation of neuronal synaptic plasticity;GO:1902883 negative regulation of response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4ABL6-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6P320-1", "uniprot_id": [ { "id": "MARHB_RAT", "url": "https://www.uniprot.org/uniprot/A6P320", "type": "external" } ], "mass": 44085.0, "length": 398, "protein_name": "E3 ubiquitin-protein ligase MARCHF11", "gene_name": "Marchf11", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase MARCHF11", "refseq_ac": [ { "id": "NP_001095298", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095298", "type": "external" } ], "gene_names_uniprotkb": "Marchf11; March11", "gene_names_refseq": "MARCH-XI; March11; Marchf11; RGD1559945", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase MARCHF11; 2.3.2.27; MARCH-XI; Membrane-associated RING finger protein 11; Membrane-associated RING-CH protein XI; RING-type E3 ubiquitin transferase MARCHF11", "protein_names_refseq": "E3 ubiquitin-protein ligase MARCH11; E3 ubiquitin-protein ligase MARCHF11; RING-type E3 ubiquitin transferase MARCH11; RING-type E3 ubiquitin transferase MARCHF11; membrane-associated RING finger protein 11; membrane-associated RING-CH protein XI; membrane-associated ring finger (C3HC4) 11", "tax_id": 10116, "disease": "", "pathway": " (rno:499558)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17604280", "class_list": "", "function": "E3 ubiquitin-protein ligase that mediates polyubiquitination of CD4. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May play a role in ubuquitin-dependent protein sorting in developmenting spermatids., [UniProtKB, PubMed]; MARCH-XI acts as a ubiquitin ligase with a role in ubiquitin-mediated protein sorting in the TGN-MVB transport pathway, which may be involved in mammalian spermiogenesis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0030659 cytoplasmic vesicle membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A6P320-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZSC8-1", "uniprot_id": [ { "id": "DJC17_RAT", "url": "https://www.uniprot.org/uniprot/D3ZSC8", "type": "external" } ], "mass": 34544.0, "length": 303, "protein_name": "DnaJ homolog subfamily C member 17", "gene_name": "Dnajc17", "organism": "Rat", "refseq_name": "dnaJ homolog subfamily C member 17", "refseq_ac": [ { "id": "NP_001178669", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178669", "type": "external" } ], "gene_names_uniprotkb": "Dnajc17", "gene_names_refseq": "Dnajc17; RGD1308015", "protein_names_uniprotkb": "DnaJ homolog subfamily C member 17", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily C, member 17; dnaJ homolog subfamily C member 17", "tax_id": 10116, "disease": "", "pathway": " (rno:311329)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "20160132", "class_list": "", "function": "May negatively affect PAX8-induced thyroglobulin/TG transcription., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0000390 spliceosomal complex disassembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZSC8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TNY7-1", "uniprot_id": [ { "id": "MYRIP_RAT", "url": "https://www.uniprot.org/uniprot/Q7TNY7", "type": "external" } ], "mass": 94985.0, "length": 856, "protein_name": "Rab effector MyRIP", "gene_name": "Myrip", "organism": "Rat", "refseq_name": "rab effector MyRIP", "refseq_ac": [ { "id": "NP_878264", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_878264", "type": "external" } ], "gene_names_uniprotkb": "Myrip; Slac2c", "gene_names_refseq": "Myrip; Slac2c", "protein_names_uniprotkb": "Rab effector MyRIP; Exophilin-8; Myosin-VIIa- and Rab-interacting protein; SlaC2-c; Slp homolog lacking C2 domains c; Synaptotagmin-like protein lacking C2 domains C", "protein_names_refseq": "exophilin-8; myosin-VIIa- and Rab-interacting protein; rab effector MyRIP; slaC2-c; slp homolog lacking C2 domains c; synaptotagmin-like protein lacking C2 domains C", "tax_id": 10116, "disease": "", "pathway": " (rno:360034); (R-RNO-9824585)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "15039459;17827149;22673903", "class_list": "", "function": "Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments (By similarity). Functions as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release., [UniProtKB, PubMed]; The Rab27B-Slac2-c complex is an important constituent of secretory granule exocytosis in parotid acinar cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0008270 zinc ion binding;GO:0017022 myosin binding;GO:0031267 small GTPase binding;GO:0051018 protein kinase A binding", "go_cellular_component": "GO:0015629 actin cytoskeleton;GO:0045202 synapse;GO:0048471 perinuclear region of cytoplasm;GO:0016324 apical plasma membrane;GO:0042470 melanosome", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0032024 positive regulation of insulin secretion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7TNY7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17625-1", "uniprot_id": [ { "id": "GYS2_RAT", "url": "https://www.uniprot.org/uniprot/P17625", "type": "external" } ], "mass": 80734.0, "length": 704, "protein_name": "Glycogen [starch] synthase, liver", "gene_name": "Gys2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gys2", "gene_names_refseq": "", "protein_names_uniprotkb": "Glycogen [starch] synthase, liver; 2.4.1.11; Glycogen synthase 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "transient cerebral ischemia (Disease Ontology:DOID:224); glycogen storage disease (Disease Ontology:DOID:2747); Lafora disease (Disease Ontology:DOID:3534)", "pathway": " (rno:25623)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "1731614;2110561;22673903", "class_list": "glycogene;glycosyltransferase", "function": "Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99MF8", "ec_number_list": [ { "id": "2.4.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.11", "type": "external" } ], "go_molecular_function": "GO:0004373 alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity;GO:0005536 D-glucose binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005938 cell cortex;GO:0030864 cortical actin cytoskeleton", "go_biological_process": "GO:0005977 glycogen metabolic process;GO:0005978 glycogen biosynthetic process;GO:0009749 response to glucose", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P17625-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000001000.0000000000001.000.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30009-1", "uniprot_id": [ { "id": "MARCS_RAT", "url": "https://www.uniprot.org/uniprot/P30009", "type": "external" } ], "mass": 29795.0, "length": 309, "protein_name": "Myristoylated alanine-rich C-kinase substrate", "gene_name": "Marcks", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Marcks; Macs", "gene_names_refseq": "", "protein_names_uniprotkb": "Myristoylated alanine-rich C-kinase substrate; MARCKS; Protein kinase C substrate 80 kDa protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "Lynch syndrome (Disease Ontology:DOID:3883)", "pathway": " (rno:25603); (R-RNO-399997)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "1396720;1707878;18683930;22673903;24662485;2676596;29393594;8422248", "class_list": "", "function": "Membrane-associated protein that plays a role in the structural modulation of the actin cytoskeleton, chemotaxis, motility, cell adhesion, phagocytosis, and exocytosis through lipid sequestering and/or protein docking to membranes (PubMed:24662485). Thus, exerts an influence on a plethora of physiological processes, such as embryonic development, tissue regeneration, neuronal plasticity, and inflammation. Sequesters phosphatidylinositol 4,5-bisphosphate (PIP2) at lipid rafts in the plasma membrane of quiescent cells, an action reversed by protein kinase C, ultimately inhibiting exocytosis. During inflammation, promotes the migration and adhesion of inflammatory cells and the secretion of cytokines such as tumor necrosis factor (TNF), particularly in macrophages. Plays an essential role in bacteria-induced intracellular reactive oxygen species (ROS) formation in the monocytic cell type. Participates in the regulation of neurite initiation and outgrowth by interacting with components of cellular machinery including CDC42 that regulates cell shape and process extension through modulation of the cytoskeleton (By similarity). Plays also a role in axon development by mediating docking and fusion of RAB10-positive vesicles with the plasma membrane (PubMed:24662485)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 21, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P20468", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005543 phospholipid binding;GO:0042802 identical protein binding;GO:0051015 actin filament binding;GO:0005080 protein kinase C binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0001520 outer dense fiber;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0007015 actin filament organization;GO:0010976 positive regulation of neuron projection development;GO:0006915 apoptotic process;GO:0007417 central nervous system development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P30009-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13444-1", "uniprot_id": [ { "id": "METK1_RAT", "url": "https://www.uniprot.org/uniprot/P13444", "type": "external" } ], "mass": 43698.0, "length": 397, "protein_name": "S-adenosylmethionine synthase isoform type-1", "gene_name": "Mat1a", "organism": "Rat", "refseq_name": "S-adenosylmethionine synthase isoform type-1", "refseq_ac": [ { "id": "NP_036992", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036992", "type": "external" } ], "gene_names_uniprotkb": "Mat1a; Ams1", "gene_names_refseq": "AdoMet; Mat1a; SADE; SAS", "protein_names_uniprotkb": "S-adenosylmethionine synthase isoform type-1; 2.5.1.6; AdoMet synthase 1; MAT 1; MAT-I/III; Methionine adenosyltransferase 1; Methionine adenosyltransferase I/III", "protein_names_refseq": "MAT 1; MAT-I/III; S - adenosylmethionine synthetase; S-adenosylmethionine synthase isoform type-1; adoMet synthase 1; adoMet synthetase 1; methionine adenosyltransferase 1; methionine adenosyltransferase I, alpha; methionine adenosyltransferase I/III", "tax_id": 10116, "disease": "hypermethioninemia (Disease Ontology:DOID:0050544); pemphigus vulgaris (Disease Ontology:DOID:0060851); lipid metabolism disorder (Disease Ontology:DOID:3146); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (rno:25331); (R-RNO-156581); (R-RNO-1614635); (R-RNO-2408508)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "10358060;10601859;10873471;12888348;1517209;1915866;22318685;27548429;2806235;34948004;7980467;9755242", "class_list": "", "function": "Catalyzes the formation of S-adenosylmethionine from methionine and ATP., [UniProtKB, UniProtKB]; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate., [UniProtKB, PubMed, PubMed, PubMed]; Polar Interactions at the Dimer-Dimer Interface of Methionine Adenosyltransferase MAT I Control Tetramerization. Publication Status: Online-Only, [RefSeq, PubMed]; The oncogene PDRG1 is an interaction target of methionine adenosyltransferases. Erratum:[PLoS One. 2016 Sep 22;11(9):e0163761. doi: 10.1371/journal.pone.0163761. PMID: 27658062] Publication Status: Online-Only, [RefSeq, PubMed]; We found for the first time a post-transcriptional regulation of MAT1A and MAT2A by AUF1 and HuR in hepatocellular carcinoma., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5FVU2", "ec_number_list": [ { "id": "2.5.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.6", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0043531 ADP binding;GO:0016597 amino acid binding", "go_cellular_component": "GO:0005829 cytosol;GO:0016363 nuclear matrix;GO:0048269 methionine adenosyltransferase complex", "go_biological_process": "GO:0051289 protein homotetramerization;GO:0006730 one-carbon metabolic process;GO:0006556 S-adenosylmethionine biosynthetic process;GO:0065003 protein-containing complex assembly;GO:0009087 L-methionine catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P13444-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K1Q4-1", "uniprot_id": [ { "id": "LZTS3_RAT", "url": "https://www.uniprot.org/uniprot/Q8K1Q4", "type": "external" } ], "mass": 75179.0, "length": 703, "protein_name": "Leucine zipper putative tumor suppressor 3", "gene_name": "Lzts3", "organism": "Rat", "refseq_name": "leucine zipper putative tumor suppressor 3", "refseq_ac": [ { "id": "NP_742019", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742019", "type": "external" } ], "gene_names_uniprotkb": "Lzts3; Prosapip1", "gene_names_refseq": "Lzts3; Prosapip1", "protein_names_uniprotkb": "Leucine zipper putative tumor suppressor 3; ProSAP-interacting protein 1; ProSAPiP1", "protein_names_refseq": "leucine zipper putative tumor suppressor 3; leucine zipper, putative tumor suppressor family member 3; proSAP-interacting protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:280670)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16522626;17120053;22673903;26364583;27252646", "class_list": "", "function": "A novel binding partner for the PDZ domain of SPAR and Shank3 proteins, ProSAPiP1, is reported and characterized., [RefSeq, PubMed]; May be involved in promoting the maturation of dendritic spines, probably via regulating SIPA1L1 levels at the postsynaptic density of synapses (PubMed:27252646)., [UniProtKB, PubMed]; Postsynaptic proteins, including ProSAPiP1/Lzts3, interacts with Sipa1L/SPAR3 in brain and is localized to excitatory postsynapses., [RefSeq, PubMed]; ProSAP/Shank and certain ProSAP/Shank-interacting proteins exhibit distinct subcellular localizations in the different cell types, raising the possibility that the function of ProSAP/Shank proteins is more diverse than has been envisaged to date., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005856 cytoskeleton;GO:0014069 postsynaptic density;GO:0043197 dendritic spine;GO:0045202 synapse", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0061001 regulation of dendritic spine morphogenesis;GO:0150052 regulation of postsynapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8K1Q4-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04905-1", "uniprot_id": [ { "id": "GSTM1_RAT", "url": "https://www.uniprot.org/uniprot/P04905", "type": "external" } ], "mass": 25914.0, "length": 218, "protein_name": "Glutathione S-transferase Mu 1", "gene_name": "Gstm1", "organism": "Rat", "refseq_name": "glutathione S-transferase Mu 1", "refseq_ac": [ { "id": "NP_058710", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058710", "type": "external" } ], "gene_names_uniprotkb": "Gstm1", "gene_names_refseq": "GSTA3; Gstm1", "protein_names_uniprotkb": "Glutathione S-transferase Mu 1; 2.5.1.18; GST 3-3; GST Yb1; GSTM1-1; Glutathione S-transferase Yb-1", "protein_names_refseq": "GST 3-3; GST Yb1; GSTM1-1; glutathione S-transferase M1; glutathione S-transferase Mu 1; glutathione S-transferase Yb-1 subunit; glutathione-S-transferase, mu type 1 (Yb1)", "tax_id": 10116, "disease": "pterygium (Disease Ontology:DOID:0002116); Stevens-Johnson syndrome (Disease Ontology:DOID:0050426); inflammatory bowel disease (Disease Ontology:DOID:0050589); diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745); colorectal adenoma (Disease Ontology:DOID:0050860); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); medulloblastoma (Disease Ontology:DOID:0050902); myelodysplastic syndrome (Disease Ontology:DOID:0050908); stroke (Disease Ontology:DOID:0051061); autism spectrum disorder (Disease Ontology:DOID:0060041); pre-malignant neoplasm (Disease Ontology:DOID:0060071); drug allergy (Disease Ontology:DOID:0060500); alcohol-associated liver disease (Disease Ontology:DOID:0070658); hepatic veno-occlusive disease (Disease Ontology:DOID:0080177); colorectal carcinoma (Disease Ontology:DOID:0080199); erythema nodosum (Disease Ontology:DOID:0080750); graft-versus-host disease (Disease Ontology:DOID:0081267); osteonecrosis (Disease Ontology:DOID:10159); thalassemia (Disease Ontology:DOID:10241); prostate cancer (Disease Ontology:DOID:10283); asbestosis (Disease Ontology:DOID:10320); lymphoid leukemia (Disease Ontology:DOID:1037); esophageal atresia (Disease Ontology:DOID:10485); Hirschsprung's disease (Disease Ontology:DOID:10487); stomach cancer (Disease Ontology:DOID:10534); primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); hypospadias (Disease Ontology:DOID:10892); urinary bladder cancer (Disease Ontology:DOID:11054); asphyxia neonatorum (Disease Ontology:DOID:11088); Human papillomavirus infectious disease (Disease Ontology:DOID:11166); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); head and neck cancer (Disease Ontology:DOID:11934); allergic disease (Disease Ontology:DOID:1205); optic neuritis (Disease Ontology:DOID:1210); aplastic anemia (Disease Ontology:DOID:12449); autistic disorder (Disease Ontology:DOID:12849); lung cancer (Disease Ontology:DOID:1324); angle-closure glaucoma (Disease Ontology:DOID:13550); cholestasis (Disease Ontology:DOID:13580); Fanconi anemia (Disease Ontology:DOID:13636); exfoliation syndrome (Disease Ontology:DOID:13641); Parkinson's disease (Disease Ontology:DOID:14330); aggressive periodontitis (Disease Ontology:DOID:1474); cystic fibrosis (Disease Ontology:DOID:1485); urticaria (Disease Ontology:DOID:1555); acute chest syndrome (Disease Ontology:DOID:1584); keratosis (Disease Ontology:DOID:161); breast cancer (Disease Ontology:DOID:1612); congenital heart disease (Disease Ontology:DOID:1682); malignant mesothelioma (Disease Ontology:DOID:1790); ovary epithelial cancer (Disease Ontology:DOID:2152); multiple sclerosis (Disease Ontology:DOID:2377); larynx cancer (Disease Ontology:DOID:2596); transitional cell carcinoma (Disease Ontology:DOID:2671); asthma (Disease Ontology:DOID:2841); cervix carcinoma (Disease Ontology:DOID:2893); pulmonary tuberculosis (Disease Ontology:DOID:2957); adenocarcinoma (Disease Ontology:DOID:299); malignant astrocytoma (Disease Ontology:DOID:3069); high grade glioma (Disease Ontology:DOID:3070); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); gallbladder cancer (Disease Ontology:DOID:3121); porphyria cutanea tarda (Disease Ontology:DOID:3132); atopic dermatitis (Disease Ontology:DOID:3310); coronary artery disease (Disease Ontology:DOID:3393); toxic encephalopathy (Disease Ontology:DOID:3602); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); Lynch syndrome (Disease Ontology:DOID:3883); gastritis (Disease Ontology:DOID:4029); systemic scleroderma (Disease Ontology:DOID:418); cervical cancer (Disease Ontology:DOID:4362); macular degeneration (Disease Ontology:DOID:4448); renal cell carcinoma (Disease Ontology:DOID:4450); movement disease (Disease Ontology:DOID:480); small intestine adenocarcinoma (Disease Ontology:DOID:4906); esophagus adenocarcinoma (Disease Ontology:DOID:4914); cholangiocarcinoma (Disease Ontology:DOID:4947); esophageal cancer (Disease Ontology:DOID:5041); liver cirrhosis (Disease Ontology:DOID:5082); schizophrenia (Disease Ontology:DOID:5419); oral submucous fibrosis (Disease Ontology:DOID:5773); leukopenia (Disease Ontology:DOID:615); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); end stage renal disease (Disease Ontology:DOID:783); periodontitis (Disease Ontology:DOID:824); cataract (Disease Ontology:DOID:83); lung disease (Disease Ontology:DOID:850); Hodgkin's lymphoma (Disease Ontology:DOID:8567); infectious mononucleosis (Disease Ontology:DOID:8568); ulcerative colitis (Disease Ontology:DOID:8577); oral cavity cancer (Disease Ontology:DOID:8618); myeloid leukemia (Disease Ontology:DOID:8692); Crohn's disease (Disease Ontology:DOID:8778); skin melanoma (Disease Ontology:DOID:8923); diabetic retinopathy (Disease Ontology:DOID:8947); polycythemia vera (Disease Ontology:DOID:8997); systemic lupus erythematosus (Disease Ontology:DOID:9074); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); oral mucosa leukoplakia (Disease Ontology:DOID:9655); senile cataract (Disease Ontology:DOID:9669); pulmonary emphysema (Disease Ontology:DOID:9675); type 1 diabetes mellitus (Disease Ontology:DOID:9744); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24423); (R-RNO-156590)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "1416995;1420139;15299462;1883338;2226415;22673903;2669745;2875437;3011803;30308595;3040722;3840477;3864155;8110735;8503873;8664265", "class_list": "", "function": "Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. The olfactory GST may be crucial for the acuity of the olfactory process (PubMed:8110735, PubMed:8664265). Participates in the formation of novel hepoxilin regioisomers (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; These data support the hypothesis that reduced renal Gstm1 plays a role in the development of hypertension., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 113, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "4.4.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.20", "type": "external" }, { "id": "5.3.99.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.2", "type": "external" }, { "id": "5.3.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.-", "type": "external" }, { "id": "5.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.2", "type": "external" }, { "id": "1.20.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.20.4.2", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0043295 glutathione binding;GO:0019899 enzyme binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0032991 protein-containing complex", "go_biological_process": "GO:0010288 response to lead ion;GO:0045471 response to ethanol;GO:0071466 cellular response to xenobiotic stimulus;GO:0042178 xenobiotic catabolic process;GO:0006693 prostaglandin metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P04905-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20428-1", "uniprot_id": [ { "id": "MYOG_RAT", "url": "https://www.uniprot.org/uniprot/P20428", "type": "external" } ], "mass": 32503.0, "length": 287, "protein_name": "Myogenin", "gene_name": "Myog", "organism": "Rat", "refseq_name": "myogenin", "refseq_ac": [ { "id": "NP_058811", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058811", "type": "external" } ], "gene_names_uniprotkb": "Myog", "gene_names_refseq": "Myog", "protein_names_uniprotkb": "Myogenin", "protein_names_refseq": "myogenin", "tax_id": 10116, "disease": "Duchenne muscular dystrophy (Disease Ontology:DOID:11723); musculoskeletal system disease (Disease Ontology:DOID:17); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:29148); (R-RNO-525793)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "14751541;1705035;25056796;2537150;26452256;26914683;35124612;9234731", "class_list": "", "function": "Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Also cooperates with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin-remodeling enzymes to alter chromatin structure at myogenic late gene promoters. Facilitates cell cycle exit during terminal muscle differentiation through the up-regulation of miR-20a expression, which in turn represses genes involved in cell cycle progression. Binds to the E-box containing (E1) promoter region of the miR-20a gene. Also plays a role in preventing reversal of muscle cell differentiation. Contributes to the atrophy-related gene expression in adult denervated muscles. Induces fibroblasts to differentiate into myoblasts., [UniProtKB, PubMed]; Low-level laser therapy (LLLT) administered following muscle injury modulates the mRNA expression of MyoD and myogenin. Moreover, the both forms of LLLT administration were able to modulate the mRNA expression of IL-6 during the muscle repair process., [RefSeq, PubMed]; Myogenin, which is expressed in MPCs, belongs to a family of basic helix-loop-helix transcription factors that activate skeletal muscle differentiation and thus plays a key role in fetal diaphragmatic development and muscularization., [RefSeq, PubMed]; Regulation of skeletal myogenesis in C2C12 cells through modulation of Pax7, MyoD, and myogenin via different low-frequency electromagnetic field energies., [RefSeq, PubMed]; Suggest that myogenin is the target for doxorubicin-induced cardio-toxicity., [RefSeq, PubMed]; This gene belongs to the myogenic factor subfamily of the basic helix-loop-helix (BHLH) family of transcription factors. The protein encoded by this gene is a muscle-specific skeletal myogenin, which acts in concert with other family members to regulate myogenesis. The protein plays an essential role in the conversion of undifferentiated cells to myoblasts and functional skeletal muscle. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0032993 protein-DNA complex", "go_biological_process": "GO:0010831 positive regulation of myotube differentiation;GO:0043403 skeletal muscle tissue regeneration;GO:0014891 striated muscle atrophy;GO:0006351 DNA-templated transcription;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P20428-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08010-1", "uniprot_id": [ { "id": "GSTM2_RAT", "url": "https://www.uniprot.org/uniprot/P08010", "type": "external" } ], "mass": 25703.0, "length": 218, "protein_name": "Glutathione S-transferase Mu 2", "gene_name": "Gstm2", "organism": "Rat", "refseq_name": "glutathione S-transferase Mu 2", "refseq_ac": [ { "id": "NP_803175", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803175", "type": "external" } ], "gene_names_uniprotkb": "Gstm2", "gene_names_refseq": "GSTA4; Gstm2", "protein_names_uniprotkb": "Glutathione S-transferase Mu 2; 2.5.1.18; GST 4-4; GST Yb2; GSTM2-2; Glutathione S-transferase Yb-2", "protein_names_refseq": "GST 4-4; GST Yb2; GSTM2-2; Glutathione-S-transferase, mu type 2 (Yb2); glutathione S-transferase M2; glutathione S-transferase Mu 2; glutathione S-transferase Yb-2; glutathione S-transferase Yb2 subunit", "tax_id": 10116, "disease": "", "pathway": " (rno:24424); (R-RNO-156590)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "2226415;22673903;27612301;3011803;3020050;3403534;3699019;3864155;8503873;8664265", "class_list": "", "function": "Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Participates in the formation of novel hepoxilin regioisomers., [UniProtKB, UniProtKB]; GSTM2C is translocated into the cytoplasm of neonatal cardiomyocytes and is effective in reducing spontaneous contractility and that its actions on field stimulated Ca2+ release and contraction is very similar to that reported for adult cardiomyocytes. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "4.4.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.20", "type": "external" }, { "id": "5.3.99.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.2", "type": "external" }, { "id": "5.3.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.-", "type": "external" }, { "id": "5.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.2", "type": "external" }, { "id": "1.20.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.20.4.2", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0043295 glutathione binding;GO:0005504 fatty acid binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0016529 sarcoplasmic reticulum;GO:0032991 protein-containing complex", "go_biological_process": "GO:0043651 linoleic acid metabolic process;GO:0006805 xenobiotic metabolic process;GO:0042178 xenobiotic catabolic process;GO:0007608 sensory perception of smell;GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P08010-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C169-1", "uniprot_id": [ { "id": "H2A1C_RAT", "url": "https://www.uniprot.org/uniprot/P0C169", "type": "external" } ], "mass": 14105.0, "length": 130, "protein_name": "Histone H2A type 1-C", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Histone H2A type 1-C", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "1268188", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P0C169-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15205-1", "uniprot_id": [ { "id": "MAP1B_RAT", "url": "https://www.uniprot.org/uniprot/P15205", "type": "external" } ], "mass": 269643.0, "length": 2461, "protein_name": "Microtubule-associated protein 1B", "gene_name": "Map1b", "organism": "Rat", "refseq_name": "microtubule-associated protein 1B", "refseq_ac": [ { "id": "NP_062090", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062090", "type": "external" } ], "gene_names_uniprotkb": "Map1b", "gene_names_refseq": "Map1b; Mtap1b", "protein_names_uniprotkb": "Microtubule-associated protein 1B; MAP-1B; Neuraxin", "protein_names_refseq": "MAP-1B; microtubule-associated protein 1B; neuraxin", "tax_id": 10116, "disease": "periventricular nodular heterotopia (Disease Ontology:DOID:0050454); autosomal dominant nonsyndromic deafness 83 (Disease Ontology:DOID:0070609); hypothyroidism (Disease Ontology:DOID:1459)", "pathway": " (rno:29456)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "15340146;1639092;16641100;18683930;22673903;2555150;28904092;30914445;38843836;8647865;8666295;9260743", "class_list": "", "function": "MAP1B restricts the access of AMPARs to dendritic spines and the postsynaptic membrane, contributing to downregulating synaptic transmission, [RefSeq, PubMed]; Required for proper microtubule dynamics. Plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (By similarity). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing (By similarity). Facilitates tyrosination of alpha-tubulin in neuronal microtubules. Required for synaptic maturation (By similarity)., [UniProtKB, UniProtKB]; This work confirms a new biological role of MAP1B in the regulation of sodium channel localization, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 96, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B0BNK3;F1LRL9;Q62958;Q9ER21;Q9QW92", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005543 phospholipid binding;GO:0008017 microtubule binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0097457 hippocampal mossy fiber;GO:0005829 cytosol;GO:0005874 microtubule;GO:0005886 plasma membrane", "go_biological_process": "GO:0032387 negative regulation of intracellular transport;GO:0047497 mitochondrion transport along microtubule;GO:0061162 establishment of monopolar cell polarity;GO:0007399 nervous system development;GO:0007409 axonogenesis", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P15205-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40615-1", "uniprot_id": [ { "id": "DKC1_RAT", "url": "https://www.uniprot.org/uniprot/P40615", "type": "external" } ], "mass": 56615.0, "length": 509, "protein_name": "H/ACA ribonucleoprotein complex subunit DKC1", "gene_name": "Dkc1", "organism": "Rat", "refseq_name": "H/ACA ribonucleoprotein complex subunit DKC1", "refseq_ac": [ { "id": "NP_596910", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_596910", "type": "external" } ], "gene_names_uniprotkb": "Dkc1; Nap57", "gene_names_refseq": "Dkc1x; Dkc1y; Dkc1; Nap57", "protein_names_uniprotkb": "H/ACA ribonucleoprotein complex subunit DKC1; 5.4.99.-; Dyskerin; Nopp140-associated protein of 57 kDa; Nucleolar protein NAP57; Nucleolar protein family A member 4; snoRNP protein DKC1", "protein_names_refseq": "H/ACA ribonucleoprotein complex subunit DKC1; dyskeratosis congenita 1, dyskerin; h/ACA ribonucleoprotein complex subunit 4; nopp140-associated protein of 57 kDa; nucleolar protein NAP57; nucleolar protein family A member 4; snoRNP protein DKC1", "tax_id": 10116, "disease": "", "pathway": " (rno:170944); (R-RNO-171319); (R-RNO-174430)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "12446766;14985449;22673903;7798307", "class_list": "", "function": "Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA (PubMed:12446766). This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1 (By similarity). Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs (By similarity). Required for ribosome biogenesis and telomere maintenance (By similarity). Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q499M9", "ec_number_list": [ { "id": "5.4.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0003720 telomerase activity;GO:0009982 pseudouridine synthase activity;GO:0034513 box H/ACA snoRNA binding;GO:0070034 telomerase RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0001650 fibrillar center;GO:0015030 Cajal body", "go_biological_process": "GO:0000455 enzyme-directed rRNA pseudouridine synthesis;GO:0090666 scaRNA localization to Cajal body;GO:0008284 positive regulation of cell population proliferation;GO:0032212 positive regulation of telomere maintenance via telomerase;GO:0000495 box H/ACA sno(s)RNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P40615-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V8F8-1", "uniprot_id": [ { "id": "MGT4D_RAT", "url": "https://www.uniprot.org/uniprot/Q4V8F8", "type": "external" } ], "mass": 43112.0, "length": 372, "protein_name": "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D", "gene_name": "Mgat4d", "organism": "Rat", "refseq_name": "alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D precursor", "refseq_ac": [ { "id": "NP_001020837", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020837", "type": "external" } ], "gene_names_uniprotkb": "Mgat4d", "gene_names_refseq": "GL54D; Mgat4d; RGD1310572", "protein_names_uniprotkb": "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D; GL54D; Glycosyltransferase 54 domain-containing protein", "protein_names_refseq": "alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D precursor; alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D; glycosyltransferase 54 domain-containing protein", "tax_id": 10116, "disease": "", "pathway": " (rno:304646)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "25808494", "class_list": "glycogene;glycosyltransferase", "function": "May play a role in male spermatogenesis. In vitro acts as inhibitor of MGAT1 activity causing cell surface proteins to carry mainly high mannose N-glycans. The function is mediated by its lumenal domain and occurs specifically in the Golgi. A catalytic glucosyltransferase activity is not detected. May be involved in regulation of Sertoli-germ cell interactions during specific stages of spermatogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008375 acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0005795 Golgi stack", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0006487 protein N-linked glycosylation;GO:0010561 negative regulation of glycoprotein biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4V8F8-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000001000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5HZE4-1", "uniprot_id": [ { "id": "MTNA_RAT", "url": "https://www.uniprot.org/uniprot/Q5HZE4", "type": "external" } ], "mass": 39587.0, "length": 369, "protein_name": "Methylthioribose-1-phosphate isomerase", "gene_name": "Mri1", "organism": "Rat", "refseq_name": "methylthioribose-1-phosphate isomerase", "refseq_ac": [ { "id": "NP_001010947", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001010947", "type": "external" } ], "gene_names_uniprotkb": "Mri1; MRI1", "gene_names_refseq": "Mri1; RGD1307789", "protein_names_uniprotkb": "Methylthioribose-1-phosphate isomerase; 5.3.1.23; M1Pi; MTR-1-P isomerase; S-methyl-5-thioribose-1-phosphate isomerase; Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein", "protein_names_refseq": "M1Pi; MTR-1-P isomerase; S-methyl-5-thioribose-1-phosphate isomerase; methylthioribose-1-phosphate isomerase homolog; methylthioribose-1-phosphate isomerase; translation initiation factor eIF-2B subunit alpha/beta/delta-like protein", "tax_id": 10116, "disease": "", "pathway": " (rno:288912); (R-RNO-1237112)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed., [UniProtKB, UniProtKB, UniProtKB]; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P)., [UniProtKB, HAMAP, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.23", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046523 S-methyl-5-thioribose-1-phosphate isomerase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005634 nucleus", "go_biological_process": "GO:0019509 L-methionine salvage from methylthioadenosine", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5HZE4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5I0I2-1", "uniprot_id": [ { "id": "MARH2_RAT", "url": "https://www.uniprot.org/uniprot/Q5I0I2", "type": "external" } ], "mass": 27169.0, "length": 246, "protein_name": "E3 ubiquitin-protein ligase MARCHF2", "gene_name": "Marchf2", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase MARCHF2", "refseq_ac": [ { "id": "NP_001029280", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029280", "type": "external" } ], "gene_names_uniprotkb": "Marchf2; March2; Rnf172", "gene_names_refseq": "MARCH-II; March2; Marchf2; RGD1306395; RNF172", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase MARCHF2; 2.3.2.27; MARCH-II; Membrane-associated RING finger protein 2; Membrane-associated RING-CH protein II; RING finger protein 172; RING-type E3 ubiquitin transferase MARCHF2; RNF172", "protein_names_refseq": "E3 ubiquitin-protein ligase MARCH2; E3 ubiquitin-protein ligase MARCHF2; RING finger protein 172; RING-type E3 ubiquitin transferase MARCH2; RING-type E3 ubiquitin transferase MARCHF2; membrane associated RING-CH finger protein II; membrane-associated RING finger protein 2; membrane-associated RING-CH protein II; membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase; syntaxin-6-binding protein", "tax_id": 10116, "disease": "", "pathway": " (rno:362849)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15689499;16428329", "class_list": "", "function": "Depletion of MARCH-II by small interfering RNA perturbed the trans-Golgi network (TGN) localization of syntaxin 6 and TGN38/46, [RefSeq, PubMed]; E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Together with GOPC/CAL mediates the ubiquitination and lysosomal degradation of CFTR (By similarity). Ubiquitinates and therefore mediates the degradation of DLG1 (By similarity). Regulates the intracellular trafficking and secretion of alpha1-antitrypsin/SERPINA1 and HP/haptoglobin via ubiquitination and degradation of the cargo receptor ERGIC3 (By similarity). Negatively regulates the antiviral and antibacterial immune response by repression of the NF-kB and type 1 IFN signaling pathways, via MARCHF2-mediated K48-linked polyubiquitination of IKBKG/NEMO, resulting in its proteasomal degradation (By similarity). May be involved in endosomal trafficking through interaction with STX6., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0044790 suppression of viral release by host;GO:1905167 positive regulation of lysosomal protein catabolic process;GO:0006897 endocytosis;GO:0016567 protein ubiquitination;GO:0140374 antiviral innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5I0I2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RKG3-1", "uniprot_id": [ { "id": "H1FNT_RAT", "url": "https://www.uniprot.org/uniprot/Q5RKG3", "type": "external" } ], "mass": 47073.0, "length": 418, "protein_name": "Testis-specific H1 histone", "gene_name": "H1-7", "organism": "Rat", "refseq_name": "testis-specific H1 histone", "refseq_ac": [ { "id": "NP_001019527", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019527", "type": "external" } ], "gene_names_uniprotkb": "H1-7; H1f7; H1fnt; Hanp1", "gene_names_refseq": "H1-7; H1f7; H1fnt", "protein_names_uniprotkb": "Testis-specific H1 histone; Haploid germ cell-specific nuclear protein 1; Histone H1.7; Histone H1t2", "protein_names_refseq": "H1 histone family, member N, testis-specific; haploid germ cell-specific nuclear protein 1; histone H1.7; histone H1t2; testis-specific H1 histone", "tax_id": 10116, "disease": "", "pathway": " (rno:500928)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;33407810", "class_list": "", "function": "Essential for normal spermatogenesis and male fertility. Required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis. Involved in the histone-protamine transition of sperm chromatin and the subsequent production of functional sperm. Binds both double-stranded and single-stranded DNA, ATP and protamine-1., [UniProtKB, UniProtKB]; Genome-wide occupancy reveals the localization of H1T2 (H1fnt) to repeat regions and a subset of transcriptionally active chromatin domains in rat spermatids. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0003690 double-stranded DNA binding;GO:0031492 nucleosomal DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0030261 chromosome condensation;GO:0045910 negative regulation of DNA recombination;GO:0007290 spermatid nucleus elongation;GO:0035092 sperm DNA condensation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5RKG3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIE5-1", "uniprot_id": [ { "id": "MARH3_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIE5", "type": "external" } ], "mass": 28563.0, "length": 253, "protein_name": "E3 ubiquitin-protein ligase MARCHF3", "gene_name": "Marchf3", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase MARCHF3", "refseq_ac": [ { "id": "NP_001007760", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007760", "type": "external" } ], "gene_names_uniprotkb": "Marchf3; March3", "gene_names_refseq": "March3; Marchf3", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase MARCHF3; 2.3.2.27; MARCH-III; Membrane-associated RING finger protein 3; Membrane-associated RING-CH protein III; RING-type E3 ubiquitin transferase MARCHF3", "protein_names_refseq": "E3 ubiquitin-protein ligase MARCH3; E3 ubiquitin-protein ligase MARCHF3; MARCH-III; RING-type E3 ubiquitin transferase MARCH3; RING-type E3 ubiquitin transferase MARCHF3; membrane-associated RING finger protein 3; membrane-associated RING-CH protein III; membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase", "tax_id": 10116, "disease": "", "pathway": " (rno:364878)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16428329", "class_list": "", "function": "E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q33E96", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005768 endosome;GO:0005764 lysosome;GO:0031901 early endosome membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XIE5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63355-1", "uniprot_id": [ { "id": "MYO1C_RAT", "url": "https://www.uniprot.org/uniprot/Q63355", "type": "external" } ], "mass": 119811.0, "length": 1044, "protein_name": "Unconventional myosin-Ic", "gene_name": "Myo1c", "organism": "Rat", "refseq_name": "unconventional myosin-Ic isoform 2", "refseq_ac": [ { "id": "NP_075580", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075580", "type": "external" } ], "gene_names_uniprotkb": "Myo1c; Myr2", "gene_names_refseq": "MMI-beta; MMIb; Myo1c; Myr2", "protein_names_uniprotkb": "Unconventional myosin-Ic; MMI-beta; MMIb; Myosin I beta; Myosin heavy chain myr 2", "protein_names_refseq": "myosin I beta; myosin IC-like; myosin heavy chain myr 2; myosin-Ic; unconventional myosin Myr2 I heavy chain; unconventional myosin-Ic isoform 2; unconventional myosin-Ic", "tax_id": 10116, "disease": "", "pathway": " (rno:65261); (R-RNO-2029482); (R-RNO-5250924)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "22673903;22918957;26940917;29393594;36513634", "class_list": "", "function": "Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes (By similarity)., [UniProtKB, PubMed, UniProtKB]; SMOC2 promotes aggressive behavior of fibroblast-like synoviocytes in rheumatoid arthritis through transcriptional and post-transcriptional regulating MYO1C. Publication Status: Online-Only, [RefSeq, PubMed]; This paper shows that inhibition of myosin 1c reduced exocytosis in alveolar type II cells, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0005903 brush border;GO:0005938 cell cortex", "go_biological_process": "GO:1900078 positive regulation of cellular response to insulin stimulus;GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0015031 protein transport;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q63355-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYP2-1", "uniprot_id": [ { "id": "MFA3L_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYP2", "type": "external" } ], "mass": 45377.0, "length": 409, "protein_name": "Microfibrillar-associated protein 3-like", "gene_name": "Mfap3l", "organism": "Rat", "refseq_name": "microfibrillar-associated protein 3-like precursor", "refseq_ac": [ { "id": "NP_001012049", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012049", "type": "external" } ], "gene_names_uniprotkb": "Mfap3l", "gene_names_refseq": "Mfap3l", "protein_names_uniprotkb": "Microfibrillar-associated protein 3-like", "protein_names_refseq": "microfibrillar-associated protein 3-like precursor; microfibrillar-associated protein 3-like", "tax_id": 10116, "disease": "", "pathway": " (rno:306424)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "May participate in the nuclear signaling of EGFR and MAPK1/ERK2., [UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030054 cell junction", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AYP2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6LED0-1", "uniprot_id": [ { "id": "H31_RAT", "url": "https://www.uniprot.org/uniprot/Q6LED0", "type": "external" } ], "mass": 15404.0, "length": 136, "protein_name": "Histone H3.1", "gene_name": "Hist1h3b", "organism": "Rat", "refseq_name": "histone H3.1", "refseq_ac": [ { "id": "NP_001013074", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013074", "type": "external" } ], "gene_names_uniprotkb": "Hist1h3b", "gene_names_refseq": "H3 histone; H3c10; Hist1h2ail1; Hist1h2ail", "protein_names_uniprotkb": "Histone H3.1", "protein_names_refseq": "histone 1, H2ai; histone H3.1; histone cluster 1 H2a family member I like 1; histone cluster 1, H2ai-like1", "tax_id": 10116, "disease": "", "pathway": " (rno:291159); (rno:679994); (rno:680498); (R-RNO-1266695); (R-RNO-212300); (R-RNO-2559580); (R-RNO-2559582); (R-RNO-3214815); (R-RNO-3214841); (R-RNO-3214842); (R-RNO-3214847); (R-RNO-3214858); (R-RNO-3247509); (R-RNO-427359); (R-RNO-427413); (R-RNO-5250924); (R-RNO-5578749); (R-RNO-5625886); (R-RNO-68616); (R-RNO-73728); (R-RNO-73772); (R-RNO-8936459); (R-RNO-9018519); (R-RNO-9764725); (R-RNO-983231); (R-RNO-9841922); (R-RNO-9843940); (R-RNO-9843970); (R-RNO-9909649); (R-RNO-9940951); (R-RNO-9943411); (R-RNO-9943962); (R-RNO-9970672)", "pathway_count": 33, "publication_count": 4, "publication_id_list": "12560483;32273471;8111130;9582357", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0031492 nucleosomal DNA binding;GO:0030527 structural constituent of chromatin;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0070062 extracellular exosome;GO:0032991 protein-containing complex;GO:0000786 nucleosome", "go_biological_process": "GO:0006334 nucleosome assembly;GO:0040029 epigenetic regulation of gene expression;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6LED0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80XX4-1", "uniprot_id": [ { "id": "MSTN1_RAT", "url": "https://www.uniprot.org/uniprot/Q80XX4", "type": "external" } ], "mass": 8985.0, "length": 82, "protein_name": "Musculoskeletal embryonic nuclear protein 1", "gene_name": "Mustn1", "organism": "Rat", "refseq_name": "musculoskeletal embryonic nuclear protein 1", "refseq_ac": [ { "id": "NP_852033", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_852033", "type": "external" } ], "gene_names_uniprotkb": "Mustn1", "gene_names_refseq": "Mustang; Mustn1", "protein_names_uniprotkb": "Musculoskeletal embryonic nuclear protein 1; Fracture callus protein MUSTANG; Musculoskeletal temporally activated novel gene protein", "protein_names_refseq": "fracture callus protein MUSTANG; musculoskeletal embryonic nuclear protein 1; musculoskeletal temporally activated novel gene protein", "tax_id": 10116, "disease": "", "pathway": " (rno:290553)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "14718386;22673903", "class_list": "", "function": "Molecular cloning and characterization of Mustang, a nuclear protein expressed during bone development and fracture healing., [RefSeq, PubMed]; Required for chondrocyte development and proliferation. Plays a role in myoblast differentiation and fusion. Modulates skeletal muscle extracellular matrix composition. Plays a role in skeletal muscle function. Plays a role in glucose homeostasis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0007517 muscle organ development;GO:0030326 embryonic limb morphogenesis;GO:0042593 glucose homeostasis;GO:0032332 positive regulation of chondrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q80XX4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q810W7-1", "uniprot_id": [ { "id": "MAST1_RAT", "url": "https://www.uniprot.org/uniprot/Q810W7", "type": "external" } ], "mass": 171028.0, "length": 1570, "protein_name": "Microtubule-associated serine/threonine-protein kinase 1", "gene_name": "Mast1", "organism": "Rat", "refseq_name": "microtubule-associated serine/threonine-protein kinase 1", "refseq_ac": [ { "id": "NP_851603", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_851603", "type": "external" } ], "gene_names_uniprotkb": "Mast1; MAST1; Sast", "gene_names_refseq": "Mast1; Sast", "protein_names_uniprotkb": "Microtubule-associated serine/threonine-protein kinase 1; 2.7.11.1; Syntrophin-associated serine/threonine-protein kinase", "protein_names_refseq": "microtubule-associated serine/threonine-protein kinase 1; syntrophin associated serine/threonine kinase; syntrophin-associated serine/threonine-protein kinase", "tax_id": 10116, "disease": "female breast cancer (Disease Ontology:DOID:0050671); mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations (Disease Ontology:DOID:0111403)", "pathway": " (rno:353118)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12614677;18206861;22673903;38843836", "class_list": "", "function": "MAST1 expression patterns are evident in the hippocampus, cerebellum, 3rd ventricle and cerebral cortex of rats., [RefSeq, PubMed]; Microtubule-associated protein essential for correct brain development (By similarity). Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Isoform 2 may play a role in neuronal transcriptional regulation., [UniProtKB, PubMed, UniProtKB]; Syntrophin-associated serine/threonine kinase-124 (Sast124) is selectively localized in the nuclei of brain neurons and is distinct from syntrophin-associated serine/threonine kinase-170, which interacts with syntrophin on the cell surface., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q810W8", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0035556 intracellular signal transduction;GO:0007010 cytoskeleton organization;GO:0007420 brain development;GO:0032502 developmental process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q810W7-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q925G1-1", "uniprot_id": [ { "id": "HDGR2_RAT", "url": "https://www.uniprot.org/uniprot/Q925G1", "type": "external" } ], "mass": 74018.0, "length": 669, "protein_name": "Hepatoma-derived growth factor-related protein 2", "gene_name": "Hdgfl2", "organism": "Rat", "refseq_name": "hepatoma-derived growth factor-related protein 2", "refseq_ac": [ { "id": "NP_598232", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598232", "type": "external" } ], "gene_names_uniprotkb": "Hdgfl2; Hdgf3; Hdgfrp2", "gene_names_refseq": "Hdgf2; Hdgfl2; Hdgfrp2", "protein_names_uniprotkb": "Hepatoma-derived growth factor-related protein 2; HDGF-3; HRP-2; Hepatoma-derived growth factor 3", "protein_names_refseq": "HDGF-3; HRP-2; hepatoma-derived growth factor 3; hepatoma-derived growth factor-related protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:171073)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16430771;22673903;26252862", "class_list": "", "function": "Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C) (By similarity). Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters (By similarity). Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs (By similarity). Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2 (By similarity). Involved in cellular growth control, through the regulation of cyclin D1 expression (By similarity)., [UniProtKB, UniProtKB]; HDGF-2 expression was significantly upregulated in the embryonic spinal cord and injured spinal cord., [RefSeq, PubMed]; HRP-2 was strongly expressed in neurons, astrocytes and oligodendrocytes in the thalamus, prefrontal and parietal cortex, neurohypophysis, and the cerebellum. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 25, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5PPH2;Q68G63", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0061628 histone H3K27me3 reader activity;GO:0062072 histone H3K9me2/3 reader activity;GO:0140566 histone reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0043403 skeletal muscle tissue regeneration;GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0006338 chromatin remodeling;GO:0030307 positive regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q925G1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99P99-1", "uniprot_id": [ { "id": "HDAC4_RAT", "url": "https://www.uniprot.org/uniprot/Q99P99", "type": "external" } ], "mass": 118652.0, "length": 1077, "protein_name": "Histone deacetylase 4", "gene_name": "Hdac4", "organism": "Rat", "refseq_name": "histone deacetylase 4 isoform 3", "refseq_ac": [ { "id": "NP_445901", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445901", "type": "external" } ], "gene_names_uniprotkb": "Hdac4", "gene_names_refseq": "Hdac4", "protein_names_uniprotkb": "Histone deacetylase 4; 3.5.1.98; HD4", "protein_names_refseq": "HD4; histone deacetylase 4 isoform 3", "tax_id": 10116, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); stroke (Disease Ontology:DOID:0051061); ataxia telangiectasia (Disease Ontology:DOID:12704); impotence (Disease Ontology:DOID:1875); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); middle cerebral artery infarction (Disease Ontology:DOID:3525); aortic aneurysm (Disease Ontology:DOID:3627); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); retinal degeneration (Disease Ontology:DOID:8466); eating disorder (Disease Ontology:DOID:8670); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:363287); (R-RNO-350054); (R-RNO-4090294); (R-RNO-4551638); (R-RNO-8951936)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "16033423;22673903;34118928;35408999;35554780;38879481", "class_list": "", "function": "HDAC4 induces the development of asthma by increasing Slug-upregulated CXCL12 expression through KLF5 deacetylation. Publication Status: Online-Only, [RefSeq, PubMed]; HDAC4 represses ER stress induced chondrocyte apoptosis by inhibiting ATF4 and attenuates cartilage degeneration in an osteoarthritis rat model. Publication Status: Online-Only, [RefSeq, PubMed]; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Role of Glucocorticoid Signaling and HDAC4 Activation in Diaphragm and Gastrocnemius Proteolytic Activity in Septic Rats. Publication Status: Online-Only, [RefSeq, PubMed]; Urine-derived stem cells-extracellular vesicles ameliorate diabetic osteoporosis through HDAC4/HIF-1alpha/VEGFA axis by delivering microRNA-26a-5p., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.5.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.48", "type": "external" }, { "id": "3.5.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.62", "type": "external" } ], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0097305 response to alcohol;GO:0048742 regulation of skeletal muscle fiber development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q99P99-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKA9-1", "uniprot_id": [ { "id": "HCN2_RAT", "url": "https://www.uniprot.org/uniprot/Q9JKA9", "type": "external" } ], "mass": 94710.0, "length": 863, "protein_name": "Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2", "gene_name": "Hcn2", "organism": "Rat", "refseq_name": "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2", "refseq_ac": [ { "id": "NP_446136", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446136", "type": "external" } ], "gene_names_uniprotkb": "Hcn2", "gene_names_refseq": "Hcn2", "protein_names_uniprotkb": "Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2", "protein_names_refseq": "hyperpolarization activated cyclic nucleotide-gated potassium channel 2; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2", "tax_id": 10116, "disease": "familial febrile seizures 2 (Disease Ontology:DOID:0111310); dermatitis (Disease Ontology:DOID:2723); meningitis (Disease Ontology:DOID:9471)", "pathway": " (rno:114244); (R-RNO-1296061)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10400919;11000485;12786975;15265006;21796099;22673903;33653265;34875252;35008085;36336089;37085778;38843836", "class_list": "", "function": "Activation of CB1R alleviates central sensitization by regulating HCN2-pNR2B signaling in a chronic migraine rat model. Publication Status: Online-Only, [RefSeq, PubMed]; Activation of HCN channels caused by elevated cAMP levels in periaqueductal gray promotes bone cancer pain., [RefSeq, PubMed]; Decreased Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 2 Activity in a Rat Model of Absence Epilepsy and the Effect of ZD7288, an Ih Inhibitor, on the Spike-and-Wave Discharges., [RefSeq, PubMed]; Densely clustered at synaptic terminals of retinal bipolar cells and photoreceptors., [RefSeq, PubMed]; Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions (PubMed:21796099). Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron (PubMed:21796099). Involved in the initiation of neuropathic pain in sensory neurons. Produces a large instantaneous current (PubMed:21796099)., [UniProtKB, PubMed]; Isolated downregulation of HCN2 in ventricles of rats with streptozotocin-induced diabetic cardiomyopathy. Publication Status: Online-Only, [RefSeq, PubMed]; Role of hyperpolarization-activated cyclic nucleotide-gated channels in aging bladder phenotype., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 1, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "F1LRY7;Q6BCT5;Q9QZW6", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0030165 PDZ domain binding;GO:0005248 voltage-gated sodium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0042391 regulation of membrane potential;GO:0071320 cellular response to cAMP;GO:0009725 response to hormone;GO:0035725 sodium ion transmembrane transport;GO:0009410 response to xenobiotic stimulus", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9JKA9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYL8-1", "uniprot_id": [ { "id": "LYPA2_RAT", "url": "https://www.uniprot.org/uniprot/Q9QYL8", "type": "external" } ], "mass": 24807.0, "length": 231, "protein_name": "Acyl-protein thioesterase 2", "gene_name": "Lypla2", "organism": "Rat", "refseq_name": "acyl-protein thioesterase 2", "refseq_ac": [ { "id": "NP_112632", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112632", "type": "external" } ], "gene_names_uniprotkb": "Lypla2", "gene_names_refseq": "Lypla2", "protein_names_uniprotkb": "Acyl-protein thioesterase 2; 3.1.2.-; 3.1.2.22; APT-2; LPL-II; LysoPLA II; Lysophospholipase 2; Lysophospholipase II; Palmitoyl-protein hydrolase", "protein_names_refseq": "APT-2; LPL-II; acyl-protein thioesterase 2; lysoPLA II; lysophospholipase II; palmitoyl-protein hydrolase", "tax_id": 10116, "disease": "", "pathway": " (rno:83510); (R-RNO-373760)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Acts as an acyl-protein thioesterase hydrolyzing fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GSDMD, GAP43, ZDHHC6 or HRAS (By similarity). Deacylates GAP43 (By similarity). Mediates depalmitoylation of ZDHHC6 (By similarity). Has lysophospholipase activity (By similarity). Hydrolyzes prostaglandin glycerol esters (PG-Gs) in the following order prostaglandin D2-glycerol ester (PGD2-G) > prostaglandin E2 glycerol ester (PGE2-G) > prostaglandin F2-alpha-glycerol ester (PGF2-alpha-G) (By similarity). Hydrolyzes 1-arachidonoylglycerol but not 2-arachidonoylglycerol or arachidonoylethanolamide (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "2.3.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.21", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.1", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" }, { "id": "3.1.1.93", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.93", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0008474 palmitoyl-(protein) hydrolase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005795 Golgi stack", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0046464 acylglycerol catabolic process;GO:1905344 prostaglandin catabolic process;GO:0002084 protein depalmitoylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9QYL8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYP0-1", "uniprot_id": [ { "id": "MEGF8_RAT", "url": "https://www.uniprot.org/uniprot/Q9QYP0", "type": "external" } ], "mass": 297554.0, "length": 2788, "protein_name": "Multiple epidermal growth factor-like domains protein 8", "gene_name": "Megf8", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Megf8; Egfl4", "gene_names_refseq": "", "protein_names_uniprotkb": "Multiple epidermal growth factor-like domains protein 8; EGF-like protein 4; Epidermal growth factor-like protein 4; Multiple EGF-like domains protein 8", "protein_names_refseq": "", "tax_id": 10116, "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545); Carpenter syndrome (Disease Ontology:DOID:0060234); Carpenter syndrome 2 (Disease Ontology:DOID:0061099)", "pathway": " (rno:114029)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16641100;38843836;9693030", "class_list": "", "function": "Acts as a negative regulator of hedgehog signaling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 9, "predicted_n_glycosites": 6, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016020 membrane;GO:0005604 basement membrane;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0060971 embryonic heart tube left/right pattern formation;GO:0060972 left/right pattern formation;GO:0097094 craniofacial suture morphogenesis;GO:0001701 in utero embryonic development;GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9QYP0-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZ76-1", "uniprot_id": [ { "id": "MYG_RAT", "url": "https://www.uniprot.org/uniprot/Q9QZ76", "type": "external" } ], "mass": 17157.0, "length": 154, "protein_name": "Myoglobin", "gene_name": "Mb", "organism": "Rat", "refseq_name": "myoglobin", "refseq_ac": [ { "id": "NP_067599", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067599", "type": "external" } ], "gene_names_uniprotkb": "Mb", "gene_names_refseq": "Glng; Mb", "protein_names_uniprotkb": "Myoglobin; 1.11.1.-; 1.7.-.-; Nitrite reductase MB; Pseudoperoxidase MB", "protein_names_refseq": "globin g; myoglobin; nitrite reductase MB; pseudoperoxidase MB", "tax_id": 10116, "disease": "COVID-19 (Disease Ontology:DOID:0080600); iron deficiency anemia (Disease Ontology:DOID:11758); hypothyroidism (Disease Ontology:DOID:1459); alcohol use disorder (Disease Ontology:DOID:1574); acute kidney failure (Disease Ontology:DOID:3021); pulmonary hypertension (Disease Ontology:DOID:6432); amphetamine abuse (Disease Ontology:DOID:670); hyperthyroidism (Disease Ontology:DOID:7998); cocaine abuse (Disease Ontology:DOID:809)", "pathway": " (rno:59108); (R-RNO-8981607)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "22673903;30658240;3118370;34502162", "class_list": "", "function": "Monomeric heme protein which primary function is to store oxygen and facilitate its diffusion within muscle tissues. Reversibly binds oxygen through a pentacoordinated heme iron and enables its timely and efficient release as needed during periods of heightened demand (PubMed:3118370). Depending on the oxidative conditions of tissues and cells, and in addition to its ability to bind oxygen, it also has a nitrite reductase activity whereby it regulates the production of bioactive nitric oxide. Under stress conditions, like hypoxia and anoxia, it also protects cells against reactive oxygen species thanks to its pseudoperoxidase activity (By similarity)., [UniProtKB, PubMed, UniProtKB]; Myoglobin and troponin concentrations are increased in early stage deep tissue injury, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.15.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.15.1.1", "type": "external" }, { "id": "1.7.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.-.-", "type": "external" }, { "id": "1.14.12.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.12.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0019825 oxygen binding;GO:0004601 peroxidase activity;GO:0005344 oxygen carrier activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0016528 sarcoplasm", "go_biological_process": "GO:0043353 enucleate erythrocyte differentiation;GO:0002931 response to ischemia;GO:0003009 skeletal muscle contraction;GO:0007507 heart development;GO:0050873 brown fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9QZ76-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62668-1", "uniprot_id": [ { "id": "UT2_RAT", "url": "https://www.uniprot.org/uniprot/Q62668", "type": "external" } ], "mass": 101896.0, "length": 929, "protein_name": "Urea transporter 2", "gene_name": "Slc14a2", "organism": "Rat", "refseq_name": "urea transporter 2 isoform 3", "refseq_ac": [ { "id": "NP_001103740", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103740", "type": "external" } ], "gene_names_uniprotkb": "Slc14a2; Ut2", "gene_names_refseq": "Slc14a2T; Slc14a2_v4; Slc14a2; UrT1-C; UrT1-D; testSymbol", "protein_names_uniprotkb": "Urea transporter 2; Solute carrier family 14 member 2; Urea transporter, kidney", "protein_names_refseq": "plasma membrane urea transporter; solute carrier family 14 (urea transporter), member 2T; testName; urea transport protein; urea transporter 2 isoform 3; urea transporter 2; urea transporter UT-A2c; urea transporter UT-A2d; urea transporter, kidney", "tax_id": 10116, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); lacrimoauriculodentodigital syndrome 1 (Disease Ontology:DOID:0050331); Beare-Stevenson cutis gyrata syndrome (Disease Ontology:DOID:0050660); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); bent bone dysplasia syndrome 1 (Disease Ontology:DOID:0060992); bone disease (Disease Ontology:DOID:0080001); Antley-Bixler syndrome (Disease Ontology:DOID:0081289); Antley-Bixler syndrome without disordered steroidogenesis (Disease Ontology:DOID:0081290); Jackson-Weiss syndrome (Disease Ontology:DOID:0111337); prostate cancer (Disease Ontology:DOID:10283); intestinal atresia (Disease Ontology:DOID:10486); stomach cancer (Disease Ontology:DOID:10534); retinitis pigmentosa (Disease Ontology:DOID:10584); portal hypertension (Disease Ontology:DOID:10762); essential hypertension (Disease Ontology:DOID:10825); hypospadias (Disease Ontology:DOID:10892); urinary bladder cancer (Disease Ontology:DOID:11054); acrocephalosyndactylia (Disease Ontology:DOID:12960); primary pulmonary hypertension (Disease Ontology:DOID:14557); Pfeiffer syndrome (Disease Ontology:DOID:14705); Saethre-Chotzen syndrome (Disease Ontology:DOID:14768); breast cancer (Disease Ontology:DOID:1612); squamous cell carcinoma (Disease Ontology:DOID:1749); transient cerebral ischemia (Disease Ontology:DOID:224); Crouzon syndrome (Disease Ontology:DOID:2339); craniosynostosis (Disease Ontology:DOID:2340); transitional cell carcinoma (Disease Ontology:DOID:2671); endometriosis (Disease Ontology:DOID:289); Epstein-Barr virus infectious disease (Disease Ontology:DOID:2938); high grade glioma (Disease Ontology:DOID:3070); dysgerminoma (Disease Ontology:DOID:4441); stomach carcinoma (Disease Ontology:DOID:5517); hepatocellular carcinoma (Disease Ontology:DOID:684); female breast carcinoma (Disease Ontology:DOID:7843); intestinal volvulus (Disease Ontology:DOID:8445); Kaposi's sarcoma (Disease Ontology:DOID:8632)", "pathway": " (rno:54302); (R-RNO-549127)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10215321;11029290;11181411;16641100;16959825;17702749;20576681;25613743;25995111;26423860;29046292;38924449;7657826;8958221", "class_list": "", "function": "Activation of cAMP/PKA increases 14-3-3gamma interactions with UT-A1 and stimulates MDM2-mediated UT-A1 ubiquitination and degradation, forming a novel regulatory mechanism of urea transport activity., [RefSeq, PubMed]; Data indicate that there are several alternative channels for urea in the rat inner medulla that could potentially contribute to the high urea permeabilities in thin limb segments., [RefSeq, PubMed]; Mediates the transport of urea driven by a concentration gradient across the cell membrane of the kidney inner medullary collecting duct which is critical to the urinary concentrating mechanism., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Report thiourea analogs as inhibitors of UT-A mediated urea transport., [RefSeq, PubMed]; UT-A1 and AQP2 interactomes provide a snapshot of a dynamic process in which UT-A1 and AQP2 are produced in the rough endoplasmic reticulum, processed through the Golgi apparatus, delivered to endosomes that move into and out of the plasma membrane, and are regulated in the plasma membrane., [RefSeq, PubMed]; Urea transporter UT-A1 as a novel drug target for hyponatremia., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 36, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9R1Y7;Q9WTT8;Q9Z2R3", "ec_number_list": [], "go_molecular_function": "GO:0050839 cell adhesion molecule binding;GO:0015204 urea transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0071918 urea transmembrane transport;GO:0015840 urea transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q62668-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13596-1", "uniprot_id": [ { "id": "NCAM1_RAT", "url": "https://www.uniprot.org/uniprot/P13596", "type": "external" } ], "mass": 94658.0, "length": 858, "protein_name": "Neural cell adhesion molecule 1", "gene_name": "Ncam1", "organism": "Rat", "refseq_name": "neural cell adhesion molecule 1 isoform 5 precursor", "refseq_ac": [ { "id": "NP_113709", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113709", "type": "external" } ], "gene_names_uniprotkb": "Ncam1; Ncam", "gene_names_refseq": "Cd56; N-CAM-1; N-CAM; NCAM-1; NCAM-C; NCAMC; Ncam1; Ncam", "protein_names_uniprotkb": "Neural cell adhesion molecule 1; N-CAM-1; NCAM-1", "protein_names_refseq": "neural cell adhesion molecule 1 isoform 5 precursor", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); ovarian serous carcinoma (Disease Ontology:DOID:0050933); acute promyelocytic leukemia (Disease Ontology:DOID:0060318); Alzheimer's disease (Disease Ontology:DOID:10652); opioid abuse (Disease Ontology:DOID:11206); hypothyroidism (Disease Ontology:DOID:1459); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); pancreatic cancer (Disease Ontology:DOID:1793); morphine dependence (Disease Ontology:DOID:2560); brain glioblastoma multiforme (Disease Ontology:DOID:3073); bipolar disorder (Disease Ontology:DOID:3312); middle cerebral artery infarction (Disease Ontology:DOID:3525); insulinoma (Disease Ontology:DOID:3892); cholangiocarcinoma (Disease Ontology:DOID:4947); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); adenoma (Disease Ontology:DOID:657); type 1 diabetes mellitus (Disease Ontology:DOID:9744); drug dependence (Disease Ontology:DOID:9974)", "pathway": " (rno:24586); (R-RNO-375165); (R-RNO-419037); (R-RNO-445144); (R-RNO-5673001)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "15240697;1699951;22673903;24090084;2483093;3680385;38219812;38728789;38843836", "class_list": "", "function": "The dynamic TRPV2 ion channel proximity proteome reveals functional links of calcium flux with cellular adhesion factors NCAM and L1CAM in neurite outgrowth., [RefSeq, PubMed]; The effects of induced type I diabetes on developmental regulation of GDNF, NRTN, and NCAM proteins in the dentate gyrus of male rat offspring., [RefSeq, PubMed]; This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 23, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0008092 cytoskeletal protein binding;GO:0019902 phosphatase binding;GO:0030275 LRR domain binding;GO:0005104 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0034109 homotypic cell-cell adhesion;GO:0006979 response to oxidative stress;GO:0007155 cell adhesion;GO:0007166 cell surface receptor signaling pathway;GO:0007611 learning or memory", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P13596-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M7W5-1", "uniprot_id": [ { "id": "MAP4_RAT", "url": "https://www.uniprot.org/uniprot/Q5M7W5", "type": "external" } ], "mass": 110301.0, "length": 1057, "protein_name": "Microtubule-associated protein 4", "gene_name": "Map4", "organism": "Rat", "refseq_name": "microtubule-associated protein 4 isoform 3", "refseq_ac": [ { "id": "NP_001019449", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019449", "type": "external" } ], "gene_names_uniprotkb": "Map4", "gene_names_refseq": "Map4; Mtap4", "protein_names_uniprotkb": "Microtubule-associated protein 4; MAP-4", "protein_names_refseq": "MAP-4; microtubule-associated protein 4 isoform 3", "tax_id": 10116, "disease": "amyotrophic lateral sclerosis (Disease Ontology:DOID:332); tauopathy (Disease Ontology:DOID:680)", "pathway": " (rno:367171)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15840943;22164227;22673903;25232678;28657654;8647865;9108484", "class_list": "", "function": "Non-neuronal microtubule-associated protein. Promotes microtubule assembly (By similarity)., [UniProtKB]; There are two possible mechanisms triggered by MAP4: stabilization of MT networks; DYNLT1 modulation, which is connected with VDAC1, and inhibition of hypoxia-induced mitochondrial permeabilization, [RefSeq, PubMed]; When targeted to mitochondria, MAP4 was found to lead to mPTP opening and induce apoptosis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 31, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q75NR5;Q75NR6", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0140778 microtubule stabilizing activity", "go_cellular_component": "GO:0005874 microtubule;GO:0005929 cilium;GO:0014069 postsynaptic density;GO:0030424 axon;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0046785 microtubule polymerization;GO:0051294 establishment of spindle orientation;GO:0031175 neuron projection development;GO:0051301 cell division;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q5M7W5-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6JP77-1", "uniprot_id": [ { "id": "AKA7G_RAT", "url": "https://www.uniprot.org/uniprot/Q6JP77", "type": "external" } ], "mass": 39418.0, "length": 353, "protein_name": "A-kinase anchor protein 7 isoforms delta and gamma", "gene_name": "Akap7", "organism": "Rat", "refseq_name": "A-kinase anchor protein 7 isoforms delta and gamma", "refseq_ac": [ { "id": "NP_001001801", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001801", "type": "external" } ], "gene_names_uniprotkb": "Akap7; Akap18", "gene_names_refseq": "AKAP-18; AKAP18d; Akap15; Akap18; Akap7", "protein_names_uniprotkb": "A-kinase anchor protein 7 isoforms delta and gamma; A-kinase anchor protein 18; AKAP-18; AKAP-7 isoforms delta and gamma; PRKA7 isoforms delta and gamma; Protein kinase A-anchoring protein 7 isoforms delta and gamma", "protein_names_refseq": "A kinase (PRKA) anchor protein 7; A-kinase anchor protein 18; A-kinase anchor protein 7 isoforms delta and gamma; A-kinase anchoring protein 18, isoform delta", "tax_id": 10116, "disease": "", "pathway": " (rno:361458)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14569017;15037626;18082768;26027516;28331977;34814703", "class_list": "", "function": "AKAP18delta Anchors and Regulates CaMKII Activity at Phospholamban-SERCA2 and RYR., [RefSeq, PubMed]; Beta-adrenergic regulation requires direct anchoring of protein kinase A to cardiac CaV1.2 channels via a leucine zipper interaction with protein kinase A-anchoring protein 15(AKAP15)., [RefSeq, PubMed]; Probably targets cAMP-dependent protein kinase (PKA) to the cellular membrane or cytoskeletal structures. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium (By similarity). Isoform Delta may be involved in shuttling aquaporin-2 (AQP2) to the plasma membrane., [UniProtKB, UniProtKB, PubMed]; Report coupling of cardiac Kir2.1 and Kir2.2 subunits with the plasma membrane-bound AKAPs 15 and 79. Cardiac membrane-associated AKAPs are a functionally essential part of the regulatory cascade determining IK1 current function., [RefSeq, PubMed]; Results confirm that AKAP7gamma/delta binding to PLB is important for phosphorylation of PLB., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3ZMQ5", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0016208 AMP binding;GO:0034237 protein kinase A regulatory subunit binding;GO:0051018 protein kinase A binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016324 apical plasma membrane;GO:0016328 lateral plasma membrane", "go_biological_process": "GO:0071320 cellular response to cAMP;GO:0001508 action potential;GO:0060306 regulation of membrane repolarization;GO:0050804 modulation of chemical synaptic transmission;GO:1901381 positive regulation of potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6JP77-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06757-1", "uniprot_id": [ { "id": "ADH1_RAT", "url": "https://www.uniprot.org/uniprot/P06757", "type": "external" } ], "mass": 39645.0, "length": 376, "protein_name": "Alcohol dehydrogenase 1", "gene_name": "Adh1c; Adh1; Adh6", "organism": "Rat", "refseq_name": "alcohol dehydrogenase 1", "refseq_ac": [ { "id": "NP_062159", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062159", "type": "external" } ], "gene_names_uniprotkb": "Adh1c; Adh1; Adh6; Adh-1; Adh1c; Adh1; Adh6", "gene_names_refseq": "Adh1a; Adh1c; Adh1; Adh", "protein_names_uniprotkb": "Alcohol dehydrogenase 1; 1.1.1.1; Alcohol dehydrogenase A subunit", "protein_names_refseq": "alcohol dehydrogenase (class I), alpha polypeptide; alcohol dehydrogenase 1 (class I), gamma polypeptide; alcohol dehydrogenase 1 (class I); alcohol dehydrogenase 1, complex; alcohol dehydrogenase 1; alcohol dehydrogenase A subunit", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); late onset Parkinson's disease (Disease Ontology:DOID:0060892); pancreatic cancer (Disease Ontology:DOID:1793)", "pathway": " (rno:24172); (R-RNO-2161541); (R-RNO-5365859); (R-RNO-71384)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "18219182;22214999;2591969;2881847;4673366", "class_list": "", "function": "ADH class I gene is progesterone-responsive in the uterus., [RefSeq, PubMed]; Study provides evidence that the simultaneous increase of liver ADH and a reduction of ALDH activity by gene transfer could constitute a potential therapeutic strategy for the treatment of alcoholism., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.1", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.284", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.284", "type": "external" }, { "id": "1.1.1.105", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.105", "type": "external" }, { "id": "1.1.1.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.66", "type": "external" } ], "go_molecular_function": "GO:0004022 alcohol dehydrogenase (NAD+) activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0001523 retinoid metabolic process;GO:0006629 lipid metabolic process;GO:0045471 response to ethanol;GO:0048149 behavioral response to ethanol;GO:0006068 ethanol catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P06757-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55146-1", "uniprot_id": [ { "id": "TYRO3_RAT", "url": "https://www.uniprot.org/uniprot/P55146", "type": "external" } ], "mass": 95919.0, "length": 880, "protein_name": "Tyrosine-protein kinase receptor TYRO3", "gene_name": "Tyro3", "organism": "Rat", "refseq_name": "tyrosine-protein kinase receptor TYRO3 precursor", "refseq_ac": [ { "id": "NP_058788", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058788", "type": "external" } ], "gene_names_uniprotkb": "Tyro3; Sky", "gene_names_refseq": "Brt; Tyro3", "protein_names_uniprotkb": "Tyrosine-protein kinase receptor TYRO3; 2.7.10.1; Tyrosine-protein kinase SKY", "protein_names_refseq": "Bruton agammaglobulinemia tyrosine kinase; TYRO3 protein tyrosine kinase 3; tyrosine-protein kinase SKY; tyrosine-protein kinase receptor TYRO3 precursor; tyrosine-protein kinase receptor TYRO3", "tax_id": 10116, "disease": "", "pathway": " (rno:25232)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21270900;22119469;22606290;22673903;7490270", "class_list": "", "function": "Analysis of novel and selective spiroindoline-based inhibitors of Sky kinase, [RefSeq, PubMed]; Nerve growth factor affected intracellular localization of full-length Axl-eGFP and Tyro-3-eCFP in PC12 cells, [RefSeq, PubMed]; Overexpression of Tyro3 in the Rat2 cell line that expresses Axl, but not Mer or Tyro3, resulted in a 5 fold increase in cell proliferation., [RefSeq, PubMed]; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3 (By similarity)., [UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" } ], "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0001618 virus receptor activity;GO:0004714 transmembrane receptor protein tyrosine kinase activity;GO:0043548 phosphatidylinositol 3-kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0043235 receptor complex", "go_biological_process": "GO:0001779 natural killer cell differentiation;GO:0006468 protein phosphorylation;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P55146-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06766-1", "uniprot_id": [ { "id": "DPOLB_RAT", "url": "https://www.uniprot.org/uniprot/P06766", "type": "external" } ], "mass": 38327.0, "length": 335, "protein_name": "DNA polymerase beta", "gene_name": "Polb", "organism": "Rat", "refseq_name": "DNA polymerase beta", "refseq_ac": [ { "id": "NP_058837", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058837", "type": "external" } ], "gene_names_uniprotkb": "Polb", "gene_names_refseq": "Polb", "protein_names_uniprotkb": "DNA polymerase beta; 2.7.7.7; 4.2.99.-; 4.2.99.18; 5'-dRP lyase; 5'-deoxyribose-phosphate lyase; AP lyase", "protein_names_refseq": "5'-dRP lyase; 5'-deoxyribose-phosphate lyase; AP lyase; DNA pol beta; DNA polymerase beta; DNA-directed DNA polymerase beta; polymerase (DNA directed), beta; polymerase (DNA) beta; polymerase-beta", "tax_id": 10116, "disease": "hereditary spastic paraplegia 64 (Disease Ontology:DOID:0110815); pre-eclampsia (Disease Ontology:DOID:10591); hypothyroidism (Disease Ontology:DOID:1459); pancreatic cancer (Disease Ontology:DOID:1793); intrahepatic cholestasis (Disease Ontology:DOID:1852); transient cerebral ischemia (Disease Ontology:DOID:224); demyelinating disease (Disease Ontology:DOID:3213); middle cerebral artery infarction (Disease Ontology:DOID:3525); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (rno:29240); (R-RNO-110362); (R-RNO-110373); (R-RNO-110381); (R-RNO-5649702); (R-RNO-5651801); (R-RNO-5689880); (R-RNO-73930)", "pathway_count": 8, "publication_count": 15, "publication_id_list": "10656829;11330999;1420147;14563842;2036395;2040602;2198936;2404980;2873575;33087265;3597402;7516581;8137427;8639559;8841120", "class_list": "", "function": "DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity., [UniProtKB, UniProtKB, UniProtKB]; History of DNA polymerase beta X-ray crystallography. Review article, [RefSeq, PubMed]; Repair polymerase that plays a key role in base-excision repair. During this process, the damaged base is excised by specific DNA glycosylases, the DNA backbone is nicked at the abasic site by an apurinic/apyrimidic (AP) endonuclease, and POLB removes 5'-deoxyribose-phosphate from the preincised AP site acting as a 5'-deoxyribose-phosphate lyase (5'-dRP lyase); through its DNA polymerase activity, it adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. It is also able to cleave sugar-phosphate bonds 3' to an intact AP site, acting as an AP lyase., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4G081", "ec_number_list": [ { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "2.7.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.78", "type": "external" }, { "id": "3.1.3.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.32", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.7.7.102", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.102", "type": "external" }, { "id": "1.14.11.51", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.51", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "1.14.11.33", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.33", "type": "external" }, { "id": "3.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.7.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.31", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" }, { "id": "3.1.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.2", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.2.1.143", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.143", "type": "external" } ], "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0051575 5'-deoxyribose-5-phosphate lyase activity;GO:0003677 DNA binding;GO:0008017 microtubule binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule;GO:0005876 spindle microtubule", "go_biological_process": "GO:0006287 base-excision repair, gap-filling;GO:0001701 in utero embryonic development;GO:0006954 inflammatory response;GO:0010332 response to gamma radiation;GO:0045471 response to ethanol", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P06766-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q00981-1", "uniprot_id": [ { "id": "UCHL1_RAT", "url": "https://www.uniprot.org/uniprot/Q00981", "type": "external" } ], "mass": 24838.0, "length": 223, "protein_name": "Ubiquitin carboxyl-terminal hydrolase isozyme L1", "gene_name": "Uchl1", "organism": "Rat", "refseq_name": "ubiquitin carboxyl-terminal hydrolase isozyme L1", "refseq_ac": [ { "id": "NP_058933", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058933", "type": "external" } ], "gene_names_uniprotkb": "Uchl1", "gene_names_refseq": "Uchl1", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase isozyme L1; 3.4.19.12; Neuron cytoplasmic protein 9.5; PGP 9.5; PGP9.5; UCH-L1; Ubiquitin thioesterase L1", "protein_names_refseq": "PGP 9.5; PGP9.5; UCH-L1; neuron cytoplasmic protein 9.5; ubiquitin carboxy-terminal hydrolase L1; ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase); ubiquitin carboxyl-terminal hydrolase isozyme L1; ubiquitin thioesterase L1", "tax_id": 10116, "disease": "late onset Parkinson's disease (Disease Ontology:DOID:0060892); hereditary spastic paraplegia 79A (Disease Ontology:DOID:0070455); hereditary spastic paraplegia 79B (Disease Ontology:DOID:0112344); Alzheimer's disease (Disease Ontology:DOID:10652); Parkinson's disease (Disease Ontology:DOID:14330); retinal disease (Disease Ontology:DOID:5679); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:29545); (R-RNO-5689603)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "11739622;12408865;1331034;22673903;30551363;31041655;34130526;36952018;38727276", "class_list": "", "function": "Long-term inhibition of UCHL1 decreases hypertension and retinopathy in spontaneously hypertensive rats., [RefSeq, PubMed]; Podocyte-specific deletion of ubiquitin carboxyl-terminal hydrolase L1 causes podocyte injury by inducing endoplasmic reticulum stress. Publication Status: Online-Only, [RefSeq, PubMed]; The Suppression of Ubiquitin C-Terminal Hydrolase L1 Promotes the Transdifferentiation of Auditory Supporting Cells into Hair Cells by Regulating the mTOR Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; The increase of UCHL1 in the damaged tubules associated with high incidence of cell death., [RefSeq, PubMed]; UCHL1-dependent autophagic flux may have a potential as an otoprotective target for the treatment of gentamycin-induced auditory cell death., [RefSeq, PubMed]; Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins (By similarity). This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin (By similarity). Also binds to free monoubiquitin and may prevent its degradation in lysosomes (By similarity). The homodimer may have ATP-independent ubiquitin ligase activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P9V8", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0030547 signaling receptor inhibitor activity;GO:0008242 omega peptidase activity;GO:0031625 ubiquitin protein ligase binding;GO:0031694 alpha-2A adrenergic receptor binding;GO:0043022 ribosome binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030424 axon", "go_biological_process": "GO:0002931 response to ischemia;GO:0007409 axonogenesis;GO:0008283 cell population proliferation;GO:0016579 protein deubiquitination;GO:0050905 neuromuscular process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q00981-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U349-1", "uniprot_id": [ { "id": "UBP2_RAT", "url": "https://www.uniprot.org/uniprot/Q5U349", "type": "external" } ], "mass": 69363.0, "length": 618, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 2", "gene_name": "Usp2", "organism": "Rat", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 2", "refseq_ac": [ { "id": "NP_446226", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446226", "type": "external" } ], "gene_names_uniprotkb": "Usp2; Ubp41; Ubp69", "gene_names_refseq": "UBP-t; Usp2", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 2; 3.4.19.12; 41 kDa ubiquitin-specific protease; Deubiquitinating enzyme 2; UBP-t; Ubiquitin thioesterase 2; Ubiquitin-specific-processing protease 2; Ubiquitin-specific-processing protease testis", "protein_names_refseq": "41 kDa ubiquitin-specific protease; deubiquitinating enzyme 2; ubiquitin carboxyl-terminal hydrolase 2; ubiquitin specific protease 2; ubiquitin thioesterase 2; ubiquitin thiolesterase 2; ubiquitin-specific-processing protease 2; ubiquitin-specific-processing protease testis", "tax_id": 10116, "disease": "", "pathway": " (rno:115771); (R-RNO-5357786); (R-RNO-5357905); (R-RNO-5357956); (R-RNO-5689880); (R-RNO-6804757)", "pathway_count": 6, "publication_count": 6, "publication_id_list": "10938131;12107281;20403044;23213472;29501527;33314748", "class_list": "", "function": "Circadian clock output effector that regulates Ca(2+) absorption in the small intestine. Probably functions by regulating protein levels of the membrane scaffold protein NHERF4 in a rhythmic manner, and is therefore likely to control Ca(2+) membrane permeability mediated by the Ca(2+) channel TRPV6 in the intestine., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1 (By similarity). Isoform 1 and isoform 2 possess both ubiquitin-specific peptidase and isopeptidase activities (PubMed:12107281). Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity (By similarity). Has no deubiquitinase activity against p53/TP53 (By similarity). Prevents MDM2-mediated degradation of MDM4 (By similarity). Plays a role in the G1/S cell-cycle progression in normal and cancer cells (By similarity). Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues (PubMed:23213472). Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability (PubMed:23213472). Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and BMAL1 (By similarity). Plays a role in the regulation of myogenic differentiation of embryonic muscle cells (PubMed:12107281)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Myogenic differentiation of embryonic muscle cells is antagonistically regulated by two deubiquitinating enzymes, UBP45 and UBP69, that are generated by alternative splicing[Usp2]., [RefSeq, PubMed]; Results have identified USP2 as a key molecule that mediates stress-induced spatial memory retrieval impairment., [RefSeq, PubMed]; Ubiquitin-specific protease 2 regulates Ang -induced cardiac fibroblasts activation by up-regulating cyclin D1 and stabilizing beta-catenin in vitro., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9QXL3;Q9QXL4;Q9R083;Q9R084", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0031625 ubiquitin protein ligase binding;GO:0004843 cysteine-type deubiquitinase activity;GO:0030332 cyclin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005938 cell cortex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0045931 positive regulation of mitotic cell cycle;GO:0007517 muscle organ development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q5U349-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5D006-1", "uniprot_id": [ { "id": "UBP11_RAT", "url": "https://www.uniprot.org/uniprot/Q5D006", "type": "external" } ], "mass": 105239.0, "length": 921, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 11", "gene_name": "Cdk16; Usp11", "organism": "Rat", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 11", "refseq_ac": [ { "id": "NP_001008861", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008861", "type": "external" } ], "gene_names_uniprotkb": "Cdk16; Usp11", "gene_names_refseq": "Uhx1; Usp11", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 11; 3.4.19.12; Deubiquitinating enzyme 11; Ubiquitin thioesterase 11; Ubiquitin-specific-processing protease 11", "protein_names_refseq": "deubiquitinating enzyme 11; ubiquitin carboxyl-terminal hydrolase 11; ubiquitin specific protease 11; ubiquitin thioesterase 11; ubiquitin-specific-processing protease 11", "tax_id": 10116, "disease": "", "pathway": " (rno:408217); (R-RNO-5689880)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "22673903;24724799;26334325;36898475;37000116", "class_list": "", "function": "Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains (in vitro). Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks. Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like comple. Promotes cell proliferation by deubiquitinating phosphorylated E2F1x., [UniProtKB, UniProtKB]; USP11 exacerbates neuronal apoptosis after traumatic brain injury via PKM2-mediated PI3K/AKT signaling pathway., [RefSeq, PubMed]; USP11 is upregulated in neurons adjacent to the hematoma following ICH., [RefSeq, PubMed]; Ubiquitin-specific protease 11 Aggravates Ischemia-reperfusion-induced Cardiomyocyte Pyroptosis and Injury by Promoting TRAF3 Deubiquitination., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F7FEA4;Q0D2L8", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004197 cysteine-type endopeptidase activity;GO:0004843 cysteine-type deubiquitinase activity;GO:0001222 transcription corepressor binding;GO:0004672 protein kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005694 chromosome", "go_biological_process": "GO:0016579 protein deubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q5D006-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q71LX6-1", "uniprot_id": [ { "id": "XIRP2_RAT", "url": "https://www.uniprot.org/uniprot/Q71LX6", "type": "external" } ], "mass": 373982.0, "length": 3302, "protein_name": "Xin actin-binding repeat-containing protein 2", "gene_name": "Xirp2", "organism": "Rat", "refseq_name": "xin actin-binding repeat-containing protein 2", "refseq_ac": [ { "id": "NP_973718", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_973718", "type": "external" } ], "gene_names_uniprotkb": "Xirp2; Cmya3; Xin2", "gene_names_refseq": "Cmya3; LACS; Xirp2", "protein_names_uniprotkb": "Xin actin-binding repeat-containing protein 2; Beta-xin; Cardiomyopathy-associated protein 3; L-NAME-induced actin cytoskeletal protein", "protein_names_refseq": "L-NAME induced actin cytoskeletal protein; beta-xin; cardiomyopathy associated 3; cardiomyopathy-associated protein 3; xin actin-binding repeat-containing protein 2", "tax_id": 10116, "disease": "depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (rno:311098)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16641100;22673903", "class_list": "", "function": "Protects actin filaments from depolymerization (By similarity). Required for correct morphology of cell membranes and maturation of intercalated disks of cardiomyocytes via facilitating localization of XIRP1 and CDH2 to the termini of aligned mature cardiomyocytes (By similarity). Thereby required for correct postnatal heart development and growth regulation that is crucial for overall heart morphology and diastolic function (By similarity). Required for normal electrical conduction in the heart including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with the cardiac ion channel components Scn5a/Nav1.5 and Kcna5/Kv1.5 (By similarity). Required for regular actin filament spacing of the paracrystalline array in both inner and outer hair cells of the cochlea, thereby required for maintenance of stereocilia morphology (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0051393 alpha-actinin binding;GO:0003779 actin binding", "go_cellular_component": "GO:0005911 cell-cell junction;GO:0005925 focal adhesion;GO:0001725 stress fiber;GO:0030018 Z disc;GO:0070161 anchoring junction", "go_biological_process": "GO:0007015 actin filament organization;GO:0055008 cardiac muscle tissue morphogenesis;GO:0003281 ventricular septum development;GO:0045216 cell-cell junction organization;GO:1903829 positive regulation of protein localization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q71LX6-1", "record_type": "protein", "filter_code": "0000000.0000111.001000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62768-1", "uniprot_id": [ { "id": "UN13A_RAT", "url": "https://www.uniprot.org/uniprot/Q62768", "type": "external" } ], "mass": 196356.0, "length": 1735, "protein_name": "Protein unc-13 homolog A", "gene_name": "Unc13a", "organism": "Rat", "refseq_name": "protein unc-13 homolog A", "refseq_ac": [ { "id": "NP_074052", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_074052", "type": "external" } ], "gene_names_uniprotkb": "Unc13a; Unc13h1", "gene_names_refseq": "Munc13-1; Unc13a; Unc13h1", "protein_names_uniprotkb": "Protein unc-13 homolog A; Munc13-1", "protein_names_refseq": "protein unc-13 homolog A", "tax_id": 10116, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); epilepsy (Disease Ontology:DOID:1826); amyotrophic lateral sclerosis (Disease Ontology:DOID:332)", "pathway": " (rno:64829)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "11343654;11792326;12163476;12871971;14734538;15667202;16052212;16271475;16704978;16732694;22673903;32086964;32643828;33468652;34227103;38755165;7559667;8999968;9195900;9697857;9736751;9895278", "class_list": "", "function": "Differential SNARE chaperoning by Munc13-1 and Munc18-1 dictates fusion pore fate at the release site. Publication Status: Online-Only, [RefSeq, PubMed]; Munc13 activates the Munc18-1/syntaxin-1 complex and enables Munc18-1 to prime SNARE assembly., [RefSeq, PubMed]; Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. Facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (By similarity). Also involved in secretory granule priming in insulin secretion. Plays a role in dendrite formation by melanocytes (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, PubMed]; Re-examining how Munc13-1 facilitates opening of syntaxin-1., [RefSeq, PubMed]; Synaptotagmin-1-, Munc18-1-, and Munc13-1-dependent liposome fusion with a few neuronal SNAREs., [RefSeq, PubMed]; Vesicle capture by membrane-bound Munc13-1 requires self-assembly into discrete clusters., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 11, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005543 phospholipid binding;GO:0008270 zinc ion binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0044305 calyx of Held;GO:0005798 Golgi-associated vesicle;GO:0005886 plasma membrane;GO:0030424 axon", "go_biological_process": "GO:1903861 positive regulation of dendrite extension;GO:0060384 innervation;GO:0048172 regulation of short-term neuronal synaptic plasticity;GO:0007528 neuromuscular junction development;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q62768-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62947-1", "uniprot_id": [ { "id": "ZEB1_RAT", "url": "https://www.uniprot.org/uniprot/Q62947", "type": "external" } ], "mass": 121627.0, "length": 1109, "protein_name": "Zinc finger E-box-binding homeobox 1", "gene_name": "Zeb1", "organism": "Rat", "refseq_name": "zinc finger E-box-binding homeobox 1", "refseq_ac": [ { "id": "NP_001295194", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001295194", "type": "external" } ], "gene_names_uniprotkb": "Zeb1; Tcf8", "gene_names_refseq": "Tcf8; Zeb1; Zfhx1a; deltaEF1", "protein_names_uniprotkb": "Zinc finger E-box-binding homeobox 1; TCF-8; Transcription factor 8; Zfhep; Zinc finger homeodomain enhancer-binding protein", "protein_names_refseq": "TCF-8; transcription factor 8 (represses interleukin 2 expression); zfhep; zinc finger E-box-binding homeobox 1; zinc finger homeodomain enhancer-binding protein", "tax_id": 10116, "disease": "rheumatic heart disease (Disease Ontology:DOID:0050827); posterior polymorphous corneal dystrophy 3 (Disease Ontology:DOID:0110857); hypospadias (Disease Ontology:DOID:10892); Fuchs' endothelial dystrophy (Disease Ontology:DOID:11555); HTLV-1-associated myelopathy/tropical spastic paraparesis (Disease Ontology:DOID:321); acute myocardial infarction (Disease Ontology:DOID:9408)", "pathway": " (rno:25705); (R-RNO-9764725)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "22673903;33846788;34032956;36123704;37246926;37391399;8769566", "class_list": "", "function": "Acts as a transcriptional repressor. Binds to E-box sequences in the immunoglobulin heavy chain enhancer as well as in the regulatory regions of many other tissue-specific genes. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). In the absence of TGFB1, acts as a repressor of COL1A2 transcription via binding to the E-box in the upstream enhancer region (By similarity)., [UniProtKB, UniProtKB]; Regulation of osteoclast differentiation and inflammatory signaling by TCF8 in periodontitis., [RefSeq, PubMed]; Vitamin D deficiency contributes to the diabetic kidney disease progression via increase ZEB1/ZEB2 expressions. Publication Status: Online-Only, [RefSeq, PubMed]; ZEB1 Induces Ddr1 Promoter Hypermethylation and Contributes to the Chronic Pain in Spinal Cord in Rats Following Oxaliplatin Treatment., [RefSeq, PubMed]; ZEB1 regulates bone metabolism in osteoporotic rats through inducing POLDIP2 transcription. Publication Status: Online-Only, [RefSeq, PubMed]; Zincfinger Eboxbinding homeobox 1 alleviates acute kidney injury by activating autophagy and the AMPK/mTOR pathway., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q62948", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0003690 double-stranded DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0017015 regulation of transforming growth factor beta receptor signaling pathway;GO:0033081 regulation of T cell differentiation in thymus;GO:0048752 semicircular canal morphogenesis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q62947-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88553-1", "uniprot_id": [ { "id": "ZFP37_RAT", "url": "https://www.uniprot.org/uniprot/O88553", "type": "external" } ], "mass": 68098.0, "length": 601, "protein_name": "Zinc finger protein 37", "gene_name": "Zfp37", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Zfp37", "gene_names_refseq": "", "protein_names_uniprotkb": "Zinc finger protein 37; Zfp-37", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:115768)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;9772206", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O88553-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08629-1", "uniprot_id": [ { "id": "TIF1B_RAT", "url": "https://www.uniprot.org/uniprot/O08629", "type": "external" } ], "mass": 88956.0, "length": 835, "protein_name": "Transcription intermediary factor 1-beta", "gene_name": "Trim28", "organism": "Rat", "refseq_name": "transcription intermediary factor 1-beta", "refseq_ac": [ { "id": "NP_446368", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446368", "type": "external" } ], "gene_names_uniprotkb": "Trim28; Kap1; Tif1b", "gene_names_refseq": "Kap1; Krip1; Tif1b; Trim28", "protein_names_uniprotkb": "Transcription intermediary factor 1-beta; 2.3.2.27; E3 SUMO-protein ligase TRIM28; KRAB-associated protein 1; Nuclear corepressor KAP-1; RING-type E3 ubiquitin transferase TIF1-beta; TIF1-beta; Tripartite motif-containing protein 28", "protein_names_refseq": "E3 SUMO-protein ligase TRIM28; KRAB-associated protein 1; RING-type E3 ubiquitin transferase TIF1-beta; TIF1-beta; nuclear corepressor KAP-1; transcription intermediary factor 1-beta; tripartite motif protein 28; tripartite motif-containing protein 28", "tax_id": 10116, "disease": "", "pathway": " (rno:116698); (R-RNO-212436); (R-RNO-3899300); (R-RNO-9843940)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "11154279;22673903;35799276", "class_list": "", "function": "E3 SUMO and ubiquitin ligase that plays a pivotal role in embryonic development, genomic imprinting, and maintenance of genomic stability through repression of repetitive and retroviral elements. Also involved in DNA repair, regulation of innate immunity or cellular energy homeostasis. Acts as a scaffold for assembling transcriptional repression complexes containing methyltransferases, histone deacetylases, and chromatin remodelers. Serves as a nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs), mediating gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1, which methylates histone H3 at Lys-9 (H3K9me), leading to heterochromatin formation. In collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Functions as a coactivator for CEBPB and NR3C1 (glucocorticoid receptor) in transcriptional activation of ORM1, and as a corepressor for ERBB4. Inhibits E2F1 activity by promoting E2F1-HDAC1 complex formation and preventing E2F1 acetylation. This contributes to CDKN1A/p21(CIP1) regulation and provides a partial backup to suppress E2F1-mediated apoptosis in the absence of RB1. Mediates the nuclear localization of several KRAB-ZFP transcription factors including KOX1, ZNF268, and ZNF300 among others. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs). Acts as a corepressor for ZFP568. Beyond its nuclear functions, acts as a positive regulator of type I interferon (IFN-I) signaling by promoting Lys-63-linked ubiquitination of TBK1, facilitating TBK1-IRF3 complex formation. Mediates TRAF6 SUMOylation to regulate its nucleo-cytoplasmic shuttling and modulate activation of the canonical NF-kappa-B signaling pathway. Facilitates SUMOylation of NLRP3, protecting it from 'Lys-48'-linked ubiquitination and proteasomal degradation and thereby enhancing inflammasome activation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; KAP1 phosphorylation promotes the survival of neural stem cells after ischemia/reperfusion by maintaining the stability of PCNA. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 24, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RYN5", "ec_number_list": [ { "id": "2.1.1.366", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.366", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.1.1.359", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.355", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355", "type": "external" }, { "id": "2.1.1.354", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354", "type": "external" }, { "id": "2.1.1.362", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.362", "type": "external" }, { "id": "2.1.1.361", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.361", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" } ], "go_molecular_function": "GO:0061665 SUMO ligase activity;GO:0035851 Krueppel-associated box domain binding;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0000791 euchromatin;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0043045 epigenetic programming of gene expression;GO:0044790 suppression of viral release by host;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O08629-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6TQE1-1", "uniprot_id": [ { "id": "ZCH18_RAT", "url": "https://www.uniprot.org/uniprot/Q6TQE1", "type": "external" } ], "mass": 105537.0, "length": 947, "protein_name": "Zinc finger CCCH domain-containing protein 18", "gene_name": "Zc3h18", "organism": "Rat", "refseq_name": "zinc finger CCCH domain-containing protein 18 isoform 2", "refseq_ac": [ { "id": "NP_958819", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_958819", "type": "external" } ], "gene_names_uniprotkb": "Zc3h18; Nhn1", "gene_names_refseq": "Nhn1; Zc3h18", "protein_names_uniprotkb": "Zinc finger CCCH domain-containing protein 18; Nuclear protein NHN1", "protein_names_refseq": "conserved nuclear protein Nhn1; nuclear protein NHN1; zinc finger CCCH domain-containing protein 18 isoform 2; zinc finger CCCH domain-containing protein 18", "tax_id": 10116, "disease": "", "pathway": " (rno:292067); (R-RNO-9930044)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 22, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6TQE2", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0030674 protein-macromolecule adaptor activity;GO:0140262 mRNA cap binding complex binding", "go_cellular_component": "GO:0016607 nuclear speck;GO:0032991 protein-containing complex;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0050779 RNA destabilization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6TQE1-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q923G5-1", "uniprot_id": [ { "id": "ZDHC7_RAT", "url": "https://www.uniprot.org/uniprot/Q923G5", "type": "external" } ], "mass": 35231.0, "length": 308, "protein_name": "Palmitoyltransferase ZDHHC7", "gene_name": "Zdhhc7", "organism": "Rat", "refseq_name": "palmitoyltransferase ZDHHC7", "refseq_ac": [ { "id": "NP_596885", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_596885", "type": "external" } ], "gene_names_uniprotkb": "Zdhhc7; Serz", "gene_names_refseq": "DHHC7; Serz-1; Serz1; Zdhhc7", "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC7; 2.3.1.-; 2.3.1.225; Acyltransferase ZDHHC7; DHHC7; Sertoli cell gene with a zinc finger domain protein; Zinc finger DHHC domain-containing protein 7", "protein_names_refseq": "DHHC-7; acyltransferase ZDHHC7; membrane-associated DHHC7 zinc finger protein; palmitoyltransferase ZDHHC7; putative zinc finger protein SERZ-1; sertoli cell gene with a zinc finger domain protein; zinc finger DHHC domain-containing protein 7; zinc finger DHHC-type palmitoyltransferase 7; zinc finger, DHHC domain containing 7; zinc finger, DHHC-type containing 7", "tax_id": 10116, "disease": "", "pathway": " (rno:170906); (R-RNO-9009391)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "11796495", "class_list": "", "function": "Golgi-localized palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes. Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane and their function in rapid intracellular signaling upon binding of sex hormones. Palmitoylates GNAQ, a heterotrimeric G protein, regulating its dynamic localization at the plasma membrane and is thereby involved in GNAQ-dependent G protein-coupled receptor signaling pathways. Also functions in ligand-induced cell death by regulating the FAS signaling pathway through the palmitoylation and stabilization of the receptor at the plasma membrane. In epithelial cells, palmitoylates SCRIB and regulates its localization to the plasma membrane, regulating indirectly cell polarity and differentiation. Also palmitoylates JAM3 and promotes its expression at tight junctions and regulates its function in cell migration (By similarity). Palmitoylates the glucose transporter GLUT4/SLC2A4 and controls the insulin-dependent translocation of GLUT4 to the plasma membrane. In brain, could also palmitoylate SNAP25 and DLG4/PSD95. Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane. Could also palmitoylate NCDN (By similarity). May play a role in follicle stimulation hormone (FSH) activation of testicular Sertoli cells (PubMed:11796495). Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD) (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2TGK0", "ec_number_list": [ { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "6.3.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.1.2", "type": "external" } ], "go_molecular_function": "GO:0019706 protein-cysteine S-palmitoyltransferase activity;GO:0016409 palmitoyltransferase activity;GO:0019705 protein-cysteine S-myristoyltransferase activity;GO:0140439 protein-cysteine S-stearoyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0006612 protein targeting to membrane;GO:0043401 steroid hormone receptor signaling pathway;GO:0030521 androgen receptor signaling pathway;GO:1903076 regulation of protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q923G5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XI00-1", "uniprot_id": [ { "id": "TCP11_RAT", "url": "https://www.uniprot.org/uniprot/Q5XI00", "type": "external" } ], "mass": 62612.0, "length": 566, "protein_name": "T-complex protein 11 homolog", "gene_name": "Tcp11", "organism": "Rat", "refseq_name": "T-complex protein 11 homolog", "refseq_ac": [ { "id": "NP_001007696", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007696", "type": "external" } ], "gene_names_uniprotkb": "Tcp11", "gene_names_refseq": "Tcp11", "protein_names_uniprotkb": "T-complex protein 11 homolog", "protein_names_refseq": "T-complex protein 11 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:309641)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Plays a role in the process of sperm capacitation and acrosome reactions. Probable receptor for the putative fertilization-promoting peptide (FPP) at the sperm membrane that may modulate the activity of the adenylyl cyclase cAMP pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0001669 acrosomal vesicle;GO:0036126 sperm flagellum;GO:0097225 sperm midpiece", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007283 spermatogenesis;GO:0007281 germ cell development;GO:0045920 negative regulation of exocytosis;GO:1902490 regulation of sperm capacitation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XI00-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q498E2-1", "uniprot_id": [ { "id": "TDRP_RAT", "url": "https://www.uniprot.org/uniprot/Q498E2", "type": "external" } ], "mass": 20171.0, "length": 182, "protein_name": "Testis development-related protein", "gene_name": "Tdrp", "organism": "Rat", "refseq_name": "testis development-related protein", "refseq_ac": [ { "id": "NP_001094261", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094261", "type": "external" } ], "gene_names_uniprotkb": "Tdrp", "gene_names_refseq": "Tdrp", "protein_names_uniprotkb": "Testis development-related protein", "protein_names_refseq": "testis development-related protein; uncharacterized protein C8orf42 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:498662)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16641100;20170638", "class_list": "", "function": "Contributes to normal sperm motility, but not essential for male fertility., [UniProtKB, UniProtKB]; These current data demonstrated that as a nuclear factor, TDRP1 might play an important role in spermatogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q498E2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RJR2-1", "uniprot_id": [ { "id": "TWF1_RAT", "url": "https://www.uniprot.org/uniprot/Q5RJR2", "type": "external" } ], "mass": 40090.0, "length": 350, "protein_name": "Twinfilin-1", "gene_name": "Twf1", "organism": "Rat", "refseq_name": "twinfilin-1", "refseq_ac": [ { "id": "NP_001008521", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008521", "type": "external" } ], "gene_names_uniprotkb": "Twf1; Ptk9", "gene_names_refseq": "Ptk9; Twf1", "protein_names_uniprotkb": "Twinfilin-1", "protein_names_refseq": "protein tyrosine kinase 9; twinfilin, actin-binding protein, homolog 1; twinfilin-1", "tax_id": 10116, "disease": "", "pathway": " (rno:315265); (R-RNO-9013418)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22673903;33963280", "class_list": "", "function": "Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Alteration of twinfilin1 expression underlies opioid withdrawal-induced remodeling of actin cytoskeleton at synapses and formation of aversive memory., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0003785 actin monomer binding;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005884 actin filament;GO:0005911 cell-cell junction;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0010976 positive regulation of neuron projection development;GO:0051016 barbed-end actin filament capping;GO:0010613 positive regulation of cardiac muscle hypertrophy;GO:0061002 negative regulation of dendritic spine morphogenesis;GO:0030837 negative regulation of actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5RJR2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JTB0-1", "uniprot_id": [ { "id": "A0A0G2JTB0_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JTB0", "type": "external" } ], "mass": 128059.0, "length": 1179, "protein_name": "Poly [ADP-ribose] polymerase", "gene_name": "Tnks2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Tnks2", "gene_names_refseq": "", "protein_names_uniprotkb": "Poly [ADP-ribose] polymerase; 2.4.2.-; PARP", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:309512); (R-RNO-201681); (R-RNO-4641257); (R-RNO-5689880); (R-RNO-8948751)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity;GO:0019899 enzyme binding;GO:0016779 nucleotidyltransferase activity;GO:0003950 NAD+ poly-ADP-ribosyltransferase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0000242 pericentriolar material", "go_biological_process": "GO:0070213 protein auto-ADP-ribosylation;GO:0040014 regulation of multicellular organism growth;GO:0035264 multicellular organism growth;GO:0070198 protein localization to chromosome, telomeric region;GO:0090263 positive regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2JTB0-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JU98-1", "uniprot_id": [ { "id": "A0A0G2JU98_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JU98", "type": "external" } ], "mass": 48303.0, "length": 439, "protein_name": "SH3 and cysteine-rich domain-containing protein 2", "gene_name": "Stac2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Stac2", "gene_names_refseq": "", "protein_names_uniprotkb": "SH3 and cysteine-rich domain-containing protein 2; 24b2/STAC2; Src homology 3 and cysteine-rich domain-containing protein 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Plays a redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity. Slows down the inactivation rate of the calcium channel CACNA1C., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0045121 membrane raft;GO:0042383 sarcolemma;GO:0009898 cytoplasmic side of plasma membrane;GO:0005829 cytosol", "go_biological_process": "GO:0003009 skeletal muscle contraction;GO:1903078 positive regulation of protein localization to plasma membrane;GO:0045671 negative regulation of osteoclast differentiation;GO:1901387 positive regulation of voltage-gated calcium channel activity", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2JU98-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JVA1-1", "uniprot_id": [ { "id": "A0A0G2JVA1_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JVA1", "type": "external" } ], "mass": 86385.0, "length": 808, "protein_name": "BCL11 transcription factor B", "gene_name": "Bcl11b", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Bcl11b", "gene_names_refseq": "", "protein_names_uniprotkb": "BCL11 transcription factor B", "protein_names_refseq": "", "tax_id": 10116, "disease": "specific developmental disorder (Disease Ontology:DOID:0060038); immunodeficiency 49 (Disease Ontology:DOID:0111979); neurodegenerative disease (Disease Ontology:DOID:1289); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (R-RNO-9933946); (R-RNO-9934037)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016514 SWI/SNF complex;GO:0043005 neuron projection", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007409 axonogenesis;GO:0008285 negative regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2JVA1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JXI6-1", "uniprot_id": [ { "id": "A0A0G2JXI6_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JXI6", "type": "external" } ], "mass": 36776.0, "length": 324, "protein_name": "CYFIP related Rac1 interactor B", "gene_name": "Cyrib", "organism": "Rat", "refseq_name": "CYFIP-related Rac1 interactor B", "refseq_ac": [ { "id": "NP_001119739", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119739", "type": "external" } ], "gene_names_uniprotkb": "Cyrib", "gene_names_refseq": "Cyrib; Fam49b; RGD1307697", "protein_names_uniprotkb": "CYFIP related Rac1 interactor B", "protein_names_refseq": "CYFIP-related Rac1 interactor B; family with sequence similarity 49, member B", "tax_id": 10116, "disease": "", "pathway": " (rno:299909); (R-RNO-114608)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding;GO:0023030 MHC class Ib protein binding, via antigen binding groove", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005929 cilium;GO:0016020 membrane", "go_biological_process": "GO:0090140 regulation of mitochondrial fission;GO:0051058 negative regulation of small GTPase mediated signal transduction;GO:0001916 positive regulation of T cell mediated cytotoxicity;GO:0030334 regulation of cell migration;GO:0032729 positive regulation of type II interferon production", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2JXI6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K7P4-1", "uniprot_id": [ { "id": "A0A0G2K7P4_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K7P4", "type": "external" } ], "mass": 35268.0, "length": 314, "protein_name": "N-terminal amino-acid N(alpha)-acetyltransferase NatA", "gene_name": "Txnl4a", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Txnl4a; Naa12; RGD1560212", "gene_names_refseq": "", "protein_names_uniprotkb": "N-terminal amino-acid N(alpha)-acetyltransferase NatA; 2.3.1.255", "protein_names_refseq": "", "tax_id": 10116, "disease": "Ogden syndrome (Disease Ontology:DOID:0050781); Burn-McKeown syndrome (Disease Ontology:DOID:0080695)", "pathway": " (rno:100911462)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes that are involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex)., [UniProtKB, UniProtKB]; Plays role in pre-mRNA splicing., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.255", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.255", "type": "external" } ], "go_molecular_function": "GO:1990189 protein N-terminal-serine acetyltransferase activity;GO:1990190 protein-N-terminal-glutamate acetyltransferase activity;GO:0004596 protein-N-terminal amino-acid acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005681 spliceosomal complex;GO:0071011 precatalytic spliceosome", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2K7P4-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0U1RRT2-1", "uniprot_id": [ { "id": "A0A0U1RRT2_RAT", "url": "https://www.uniprot.org/uniprot/A0A0U1RRT2", "type": "external" } ], "mass": 37879.0, "length": 337, "protein_name": "Solute carrier family 25 member 44", "gene_name": "Slc25a44", "organism": "Rat", "refseq_name": "solute carrier family 25 member 44", "refseq_ac": [ { "id": "NP_001102417", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102417", "type": "external" } ], "gene_names_uniprotkb": "Slc25a44", "gene_names_refseq": "RGD1307244; Slc25a44", "protein_names_uniprotkb": "Solute carrier family 25 member 44", "protein_names_refseq": "solute carrier family 25 member 44", "tax_id": 10116, "disease": "", "pathway": " (rno:365841)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mitochondrial solute transporter which transports branched-chain amino acid (BCAA; valine, leucine and isoleucine) into mitochondria in brown adipose tissue (BAT). BAT is involved in BCAA catabolism and actively utilizes BCAA in the mitochondria for thermogenesis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015658 branched-chain amino acid transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane;GO:0016020 membrane", "go_biological_process": "GO:0009083 branched-chain amino acid catabolic process;GO:0006865 amino acid transport;GO:0015803 branched-chain amino acid transport;GO:0120161 regulation of cold-induced thermogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0U1RRT2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3B0IP42-1", "uniprot_id": [ { "id": "A0A3B0IP42_RAT", "url": "https://www.uniprot.org/uniprot/A0A3B0IP42", "type": "external" } ], "mass": 27107.0, "length": 266, "protein_name": "Complement C1q like 2", "gene_name": "C1ql2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "C1ql2", "gene_names_refseq": "", "protein_names_uniprotkb": "Complement C1q like 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:288979)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "M0RB98", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0045202 synapse;GO:0043083 synaptic cleft", "go_biological_process": "GO:0097107 postsynaptic density assembly;GO:0099558 maintenance of synapse structure;GO:0090128 regulation of synapse maturation;GO:0099550 trans-synaptic signaling, modulating synaptic transmission;GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3B0IP42-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5XW39-1", "uniprot_id": [ { "id": "A0A8I5XW39_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5XW39", "type": "external" } ], "mass": 49197.0, "length": 438, "protein_name": "Serine/threonine-protein kinase VRK1", "gene_name": "Vrk1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Vrk1", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine/threonine-protein kinase VRK1; 2.7.11.1; Vaccinia-related kinase 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "pontocerebellar hypoplasia type 1A (Disease Ontology:DOID:0060265); autosomal recessive distal hereditary motor neuronopathy 10 (Disease Ontology:DOID:0081429)", "pathway": " (R-RNO-2980766); (R-RNO-2995383)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": 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Can both act as a transcriptional activator or repressor. Plays a negative regulatory role in cells of the immune system. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes. Required for the development of plasmacytoid dendritic cells (pDCs), which produce most of the type I IFN in response to viral infection. Positively regulates macroautophagy in dendritic cells. 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(R-RNO-381426); (R-RNO-5625970); (R-RNO-8957275); (R-RNO-8980692); (R-RNO-9013148); (R-RNO-9013149); (R-RNO-9013408); (R-RNO-9696264); (R-RNO-9696270)", "pathway_count": 10, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019894 kinesin binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0015031 protein transport;GO:0007018 microtubule-based movement", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8I6A4W2-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5YBL7-1", "uniprot_id": [ { "id": "A0A8I5YBL7_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5YBL7", "type": "external" } ], "mass": 140405.0, "length": 1313, "protein_name": "Poly [ADP-ribose] polymerase", "gene_name": "Tnks", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Tnks", "gene_names_refseq": "", "protein_names_uniprotkb": "Poly [ADP-ribose] polymerase; 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Celf4", "protein_names_uniprotkb": "CUGBP Elav-like family member 4; Bruno-like protein 4; CUG-BP- and ETR-3-like factor 4; RNA-binding protein BRUNOL-4", "protein_names_refseq": "CUG-BP- and ETR-3-like factor 4; CUGBP Elav-like family member 4", "tax_id": 10116, "disease": "myotonic dystrophy type 1 (Disease Ontology:DOID:11722); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (rno:307540)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Promotes exclusion of both the smooth muscle (SM) and non-muscle (NM) exons in actinin pre-mRNAs. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, 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"A0A8I5ZKI3-1", "uniprot_id": [ { "id": "A0A8I5ZKI3_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5ZKI3", "type": "external" } ], "mass": 55717.0, "length": 481, "protein_name": "PRAME family member 8 like 2", "gene_name": "Pramef8l2", "organism": "Rat", "refseq_name": "PRAME family member 8-like isoform X2", "refseq_ac": [ { "id": "XP_577321", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_577321", "type": "external" } ], "gene_names_uniprotkb": "Pramef8l2; RGD1559654", "gene_names_refseq": "Pramef8l2", "protein_names_uniprotkb": "PRAME family member 8 like 2", "protein_names_refseq": "PRAME family member 8-like isoform X2", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, 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adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031462 Cul2-RING ubiquitin ligase complex", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0045892 negative regulation of DNA-templated transcription;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045596 negative regulation of cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I5ZKI3-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5ZKI9-1", "uniprot_id": [ { "id": "A0A8I5ZKI9_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5ZKI9", "type": "external" } ], "mass": 111136.0, "length": 978, "protein_name": "BICD cargo adaptor 1", "gene_name": "Bicd1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], 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receptor-mediated endocytosis;GO:0019068 virion assembly;GO:0034063 stress granule assembly;GO:0070507 regulation of microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I5ZKI9-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5ZKU3-1", "uniprot_id": [ { "id": "A0A8I5ZKU3_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5ZKU3", "type": "external" } ], "mass": 60804.0, "length": 524, "protein_name": "Zinc finger protein 709-like", "gene_name": "LOC108348302", "organism": "Rat", "refseq_name": "zinc finger protein 709-like isoform X1", "refseq_ac": [ { "id": "XP_063132001", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_063132001", "type": "external" } ], "gene_names_uniprotkb": "LOC108348302", "gene_names_refseq": "LOC108348302", "protein_names_uniprotkb": "Zinc finger protein 709-like", "protein_names_refseq": "zinc finger protein 709-like isoform X1", "tax_id": 10116, "disease": "", "pathway": " (rno:108348302)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I5ZKU3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5ZKZ5-1", "uniprot_id": [ { "id": "A0A8I5ZKZ5_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5ZKZ5", "type": "external" } ], "mass": 122022.0, "length": 1074, "protein_name": "Gem (nuclear organelle) associated protein 4", "gene_name": "Gemin4", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gemin4", "gene_names_refseq": "", "protein_names_uniprotkb": "Gem (nuclear organelle) associated protein 4", "protein_names_refseq": "", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); neurodevelopmental disorder with microcephaly, cataracts, and renal abnormalities (Disease Ontology:DOID:0081263)", "pathway": " (rno:497958)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, 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0.1, "record_id": "A0A8I5ZRC7-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5ZS42-1", "uniprot_id": [ { "id": "A0A8I5ZS42_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5ZS42", "type": "external" } ], "mass": 40745.0, "length": 365, "protein_name": "Uncharacterized protein", "gene_name": "ENSRNOG00000069809", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ENSRNOG00000069809; LOC102548568", "gene_names_refseq": "", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I5ZS42-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5ZSA5-1", "uniprot_id": [ { "id": "A0A8I5ZSA5_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5ZSA5", "type": "external" } ], "mass": 19845.0, "length": 182, "protein_name": "Small ribosomal subunit protein uS5", "gene_name": "Rps2-ps17", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Rps2-ps17", "gene_names_refseq": "", "protein_names_uniprotkb": "Small ribosomal subunit protein uS5; 40S ribosomal protein S2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:302961)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. Plays a role in the assembly and function of the 40S ribosomal subunit. Mutations in this protein affects the control of translational fidelity. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I5ZSA5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5ZSK4-1", "uniprot_id": [ { "id": "A0A8I5ZSK4_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5ZSK4", "type": "external" } ], "mass": 158370.0, "length": 1405, "protein_name": "Melanoma inhibitory activity protein 2", "gene_name": "Mia2", "organism": "Rat", "refseq_name": "melanoma inhibitory activity protein 2 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001358270", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001358270", "type": "external" } ], "gene_names_uniprotkb": "Mia2; Ctage5; LOC100912115", "gene_names_refseq": "Ctage5; Mgea6; Mia2", "protein_names_uniprotkb": "Melanoma inhibitory activity protein 2; CTAGE family member 5 ER export factor", "protein_names_refseq": "CTAGE family member 5, ER export factor; CTAGE family, member 5; cutaneous T-cell lymphoma-associated antigen 5 homolog; melanoma inhibitory activity 2; melanoma inhibitory activity protein 2 isoform 1 precursor; melanoma inhibitory activity protein 2; meningioma expressed antigen 6 (coiled-coil proline-rich)", "tax_id": 10116, "disease": "", "pathway": " (rno:100912115); (R-RNO-5694530)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. Plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum. Thereby, may play a role in cholesterol and triglyceride homeostasis. Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0038024 cargo receptor activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0070971 endoplasmic reticulum exit site;GO:0016020 membrane", "go_biological_process": "GO:0042953 lipoprotein transport;GO:0042632 cholesterol homeostasis;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0009306 protein secretion;GO:0070328 triglyceride homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8I5ZSK4-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5ZTI4-1", "uniprot_id": [ { "id": "A0A8I5ZTI4_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5ZTI4", "type": "external" } ], "mass": 112040.0, "length": 967, "protein_name": "Uncharacterized protein", "gene_name": "ENSRNOG00000063185; ENSRNOG00000065506; ENSRNOG00000068622; LOC108348267; LOC134478814; Zfp431l10; Zfp808l2; Zfp808l3; Znf431l2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ENSRNOG00000063185; ENSRNOG00000065506; ENSRNOG00000068622; LOC108348267; LOC134478814; Zfp431l10; Zfp808l2; Zfp808l3; Znf431l2; ENSRNOG00000068622; LOC102549249; LOC102552000; LOC108348224; LOC134478814; Zfp431l10; Zfp715-ps4; Znf431l14; Znf431l2", "gene_names_refseq": "", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-212436); (R-RNO-9843940)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I5ZTI4-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5ZSP1-1", "uniprot_id": [ { "id": "A0A8I5ZSP1_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5ZSP1", "type": "external" } ], "mass": 67629.0, "length": 592, "protein_name": "Zinc finger protein 37 homolog", "gene_name": "AABR07048473.1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "AABR07048473.1", "gene_names_refseq": "", "protein_names_uniprotkb": "Zinc finger protein 37 homolog", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, 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sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I5ZSP1-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5ZSU2-1", "uniprot_id": [ { "id": "A0A8I5ZSU2_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5ZSU2", "type": "external" } ], "mass": 62155.0, "length": 564, "protein_name": "CCM2 like scaffold protein", "gene_name": "Ccm2l", "organism": "Rat", "refseq_name": "cerebral cavernous malformations 2 protein-like isoform X1", "refseq_ac": [ { "id": "XP_038962791", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_038962791", "type": "external" } ], "gene_names_uniprotkb": "Ccm2l; RGD1305202", "gene_names_refseq": "Ccm2l", "protein_names_uniprotkb": "CCM2 like scaffold protein", "protein_names_refseq": "cerebral cavernous malformations 2 protein-like isoform X1", "tax_id": 10116, "disease": "", "pathway": " (rno:311550)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0003007 heart morphogenesis;GO:0042060 wound healing;GO:0003222 ventricular trabecula myocardium morphogenesis;GO:0003209 cardiac atrium morphogenesis;GO:0034111 negative regulation of homotypic cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I5ZSU2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5ZSW2-1", "uniprot_id": [ { "id": "A0A8I5ZSW2_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5ZSW2", "type": "external" } ], "mass": 15742.0, "length": 136, "protein_name": "60S ribosomal protein L27", "gene_name": "Rpl27l1", "organism": "Rat", "refseq_name": "ribosomal protein L27-like 1", "refseq_ac": [ { "id": "NP_001395822", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001395822", "type": "external" } ], "gene_names_uniprotkb": "Rpl27l1; AABR07039133.2; Rpl27-l1", "gene_names_refseq": "Rpl27-l1; Rpl27l1", "protein_names_uniprotkb": "60S ribosomal protein L27", "protein_names_refseq": "60S ribosomal protein L27-like; ribosomal protein L27-like 1", "tax_id": 10116, "disease": "", "pathway": " (rno:688784)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the large ribosomal subunit. Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005791 rough endoplasmic reticulum;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I5ZSW2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6A895-1", "uniprot_id": [ { "id": "A0A8I6A895_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6A895", "type": "external" } ], "mass": 153084.0, "length": 1371, "protein_name": "Zinc finger MYM-type containing 3", "gene_name": "Zmym3", "organism": "Rat", "refseq_name": "zinc finger MYM-type protein 3", "refseq_ac": [ { "id": "NP_001035245", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035245", "type": "external" } ], "gene_names_uniprotkb": "Zmym3", "gene_names_refseq": "Zmym3", "protein_names_uniprotkb": "Zinc finger MYM-type containing 3", "protein_names_refseq": "zinc finger MYM-type protein 3; zinc finger, MYM-type 3", "tax_id": 10116, "disease": "non-syndromic X-linked intellectual disability (Disease Ontology:DOID:0050776)", "pathway": " (rno:317260)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8I6A895-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5ZU57-1", "uniprot_id": [ { "id": "A0A8I5ZU57_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5ZU57", "type": "external" } ], "mass": 39368.0, "length": 341, "protein_name": "Cyclin Y", "gene_name": "Ccny", "organism": "Rat", "refseq_name": "cyclin-Y", "refseq_ac": [ { "id": "NP_001178762", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178762", "type": "external" } ], "gene_names_uniprotkb": "Ccny", "gene_names_refseq": "Ccny; RGD1565969", "protein_names_uniprotkb": "Cyclin Y", "protein_names_refseq": "cyclin-Y", "tax_id": 10116, "disease": "", "pathway": " (rno:361261)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16396499;22673903;26220330;28241067", "class_list": "", "function": "CCNY may be involved in hippocampal neuronal system Publication Status: Online-Only, [RefSeq, PubMed]; Data show that cyclin Y (CCNY) negatively regulates long-term potentiation (LTP) of synaptic strength through inhibition of AMPA receptor trafficking. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity;GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005886 plasma membrane;GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex", "go_biological_process": "GO:0000086 G2/M transition of mitotic cell cycle;GO:0010508 positive regulation of autophagy;GO:0016055 Wnt signaling pathway;GO:0060828 regulation of canonical Wnt signaling pathway;GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A8I5ZU57-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5ZUY9-1", "uniprot_id": [ { "id": "A0A8I5ZUY9_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5ZUY9", "type": "external" } ], "mass": 27717.0, "length": 253, "protein_name": "Prohibitin", "gene_name": "Phb1l2", "organism": "Rat", "refseq_name": "prohibitin 1-like", "refseq_ac": [ { "id": "XP_038954058", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_038954058", "type": "external" } ], "gene_names_uniprotkb": "Phb1l2; LOC688815", "gene_names_refseq": "Phb1l2", "protein_names_uniprotkb": "Prohibitin", "protein_names_refseq": "prohibitin 1-like", "tax_id": 10116, "disease": "breast cancer (Disease Ontology:DOID:1612); transitional cell carcinoma (Disease Ontology:DOID:2671); sporadic breast cancer (Disease Ontology:DOID:8029); prostate carcinoma in situ (Disease Ontology:DOID:8634); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991)", "pathway": " (rno:688815)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "In the nucleus, acts as a transcription coregulator, enhances promoter binding by TP53, a transcription factor it activates, but reduces the promoter binding by E2F1, a transcription factor it represses. Interacts with STAT3 to affect IL17 secretion in T-helper Th17 cells., [UniProtKB, UniProtKB]; In the plasma membrane, cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates. Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation., [UniProtKB, UniProtKB]; Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors in the nucleus. Plays a role in adipose tissue and glucose homeostasis in a sex-specific manner. Contributes to pulmonary vascular remodeling by accelerating proliferation of pulmonary arterial smooth muscle cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0071897 DNA biosynthetic process;GO:0007005 mitochondrion organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I5ZUY9-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5ZVH2-1", "uniprot_id": [ { "id": "A0A8I5ZVH2_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5ZVH2", "type": "external" } ], "mass": 342187.0, "length": 3111, "protein_name": "Bromodomain PHD finger transcription factor", "gene_name": "Bptf", "organism": "Rat", "refseq_name": "nucleosome-remodeling factor subunit BPTF", "refseq_ac": [ { "id": "NP_001121007", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121007", "type": "external" } ], "gene_names_uniprotkb": "Bptf", "gene_names_refseq": "Bptf; Falz", "protein_names_uniprotkb": "Bromodomain PHD finger transcription factor", "protein_names_refseq": "fetal Alzheimer antigen; nucleosome-remodeling factor subunit BPTF", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); neurodevelopmental disorder with dysmorphic facies and distal limb anomalies (Disease Ontology:DOID:0070514); Alzheimer's disease (Disease Ontology:DOID:10652); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); Kaposi's sarcoma (Disease Ontology:DOID:8632)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, 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"secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0043565 sequence-specific DNA binding;GO:0008094 ATP-dependent activity, acting on DNA", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0030425 dendrite;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8I5ZVH2-1", "record_type": "protein", "filter_code": "0000000.0000110.001000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5ZVJ6-1", "uniprot_id": [ { "id": "A0A8I5ZVJ6_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5ZVJ6", "type": "external" } ], "mass": 94514.0, "length": 847, "protein_name": "Doublecortin domain containing 1, pseudogene 1", "gene_name": "Dcdc1-ps1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Dcdc1-ps1", "gene_names_refseq": "", "protein_names_uniprotkb": "Doublecortin domain containing 1, pseudogene 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, 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"A0A8I5ZVJ6-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5ZVX9-1", "uniprot_id": [ { "id": "A0A8I5ZVX9_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5ZVX9", "type": "external" } ], "mass": 29979.0, "length": 259, "protein_name": "DnaJ homolog subfamily C member 9", "gene_name": "Dnajc9", "organism": "Rat", "refseq_name": "dnaJ homolog subfamily C member 9", "refseq_ac": [ { "id": "NP_001102335", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102335", "type": "external" } ], "gene_names_uniprotkb": "Dnajc9", "gene_names_refseq": "Dnajc9; JDD1", "protein_names_uniprotkb": "DnaJ homolog subfamily C member 9", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily C, member 9; DnaJ-like factor; dnaJ homolog subfamily C member 9", "tax_id": 10116, "disease": "", "pathway": " (rno:364240)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Acts as a dual histone chaperone and heat shock co-chaperone. As a histone chaperone, forms a co-chaperone complex with MCM2 and histone H3-H4 heterodimers; and may thereby assist MCM2 in histone H3-H4 heterodimer recognition and facilitate the assembly of histones into nucleosomes. May also act as a histone co-chaperone together with TONSL. May recruit histone chaperones ASF1A, NASP and SPT2 to histone H3-H4 heterodimers. Also plays a role as co-chaperone of the HSP70 family of molecular chaperone proteins, such as HSPA1A, HSPA1B and HSPA8. As a co-chaperone, may play a role in the recruitment of HSP70-type molecular chaperone machinery to histone H3-H4 substrates, thereby maintaining the histone structural integrity. Exhibits activity to assemble histones onto DNA in vitro., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, 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"secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008190 eukaryotic initiation factor 4E binding;GO:0030371 translation repressor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0098794 postsynapse;GO:0071598 neuronal ribonucleoprotein granule", "go_biological_process": "GO:0007613 memory;GO:0048167 regulation of synaptic plasticity;GO:0035176 social behavior;GO:0008286 insulin receptor signaling pathway;GO:0031929 TOR signaling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6A0I3-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6A0L8-1", "uniprot_id": [ { "id": "A0A8I6A0L8_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6A0L8", "type": "external" } ], "mass": 63222.0, "length": 577, "protein_name": "Interleukin-22 receptor subunit alpha-1", "gene_name": "Il22ra1", "organism": "Rat", "refseq_name": "interleukin-22 receptor subunit alpha-1 precursor", "refseq_ac": [ { "id": "NP_001178798", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178798", "type": "external" } ], "gene_names_uniprotkb": "Il22ra1", "gene_names_refseq": "Il22ra1; RGD1559655", "protein_names_uniprotkb": "Interleukin-22 receptor subunit alpha-1", "protein_names_refseq": "interleukin 22 receptor, alpha 1; interleukin-22 receptor subunit alpha-1 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:362629); (R-RNO-8854691)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042018 interleukin-22 receptor activity;GO:0004896 cytokine receptor activity;GO:0042015 interleukin-20 binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0030876 interleukin-20 receptor complex", "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium;GO:0050728 negative regulation of inflammatory response;GO:0019221 cytokine-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6A0L8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6A140-1", "uniprot_id": [ { "id": "A0A8I6A140_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6A140", "type": "external" } ], "mass": 72086.0, "length": 638, "protein_name": "Kelch-like family member 13", "gene_name": "Klhl13", "organism": "Rat", "refseq_name": "kelch-like protein 13 isoform c", "refseq_ac": [ { "id": "NP_001094324", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094324", "type": "external" } ], "gene_names_uniprotkb": "Klhl13; Klhl9", "gene_names_refseq": "Klhl13", "protein_names_uniprotkb": "Kelch-like family member 13", "protein_names_refseq": "kelch-like protein 13 isoform c; kelch-like protein 13", "tax_id": 10116, "disease": "", "pathway": " (rno:313445); (R-RNO-8951664); (R-RNO-983168)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. 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"0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6A1A6-1", "uniprot_id": [ { "id": "A0A8I6A1A6_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6A1A6", "type": "external" } ], "mass": 82961.0, "length": 765, "protein_name": "RING-type E3 ubiquitin transferase", "gene_name": "Rfwd3", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase RFWD3 isoform 2", "refseq_ac": [ { "id": "NP_001389131", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001389131", "type": "external" } ], "gene_names_uniprotkb": "Rfwd3", "gene_names_refseq": "RGD1305243; Rfwd3", "protein_names_uniprotkb": "RING-type E3 ubiquitin transferase; 2.3.2.27", "protein_names_refseq": "E3 ubiquitin-protein ligase RFWD3 isoform 2; E3 ubiquitin-protein ligase RFWD3-like", "tax_id": 10116, "disease": "Fanconi anemia complementation group W (Disease Ontology:DOID:0060978)", "pathway": "", "pathway_count": 0, "publication_count": 0, 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"A0A8I6A2D2-1", "uniprot_id": [ { "id": "A0A8I6A2D2_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6A2D2", "type": "external" } ], "mass": 25040.0, "length": 219, "protein_name": "Ankyrin repeat domain 22", "gene_name": "Ankrd22", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ankrd22", "gene_names_refseq": "", "protein_names_uniprotkb": "Ankyrin repeat domain 22", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:294093)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, 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"synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6A2D2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6A2J7-1", "uniprot_id": [ { "id": "A0A8I6A2J7_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6A2J7", "type": "external" } ], "mass": 46269.0, "length": 400, "protein_name": "Family with sequence similarity 47, member E", "gene_name": "Fam47e", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Fam47e", "gene_names_refseq": "", "protein_names_uniprotkb": "Family with sequence similarity 47, member E", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, 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"ec_number_list": [], "go_molecular_function": "GO:0008047 enzyme activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000785 chromatin", "go_biological_process": "GO:0045815 transcription initiation-coupled chromatin remodeling;GO:0071168 protein localization to chromatin", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6A2J7-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6A3D9-1", "uniprot_id": [ { "id": "A0A8I6A3D9_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6A3D9", "type": "external" } ], "mass": 15721.0, "length": 142, "protein_name": "Small nuclear ribonucleoprotein Sm D3", "gene_name": "Snrpd3l1", "organism": "Rat", "refseq_name": "small nuclear ribonucleoprotein Sm D3-like", "refseq_ac": [ { "id": "XP_038954253", "url": 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Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005829 cytosol;GO:0071013 catalytic step 2 spliceosome;GO:0005686 U2 snRNP;GO:0071011 precatalytic spliceosome", "go_biological_process": "GO:0000387 spliceosomal snRNP assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6A3D9-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6A3E4-1", "uniprot_id": [ { "id": "A0A8I6A3E4_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6A3E4", "type": "external" } ], "mass": 34920.0, "length": 313, "protein_name": "Olfactory receptor", "gene_name": "Or1f27", "organism": "Rat", "refseq_name": "olfactory receptor Olr1374", "refseq_ac": [ { "id": "NP_001000978", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001000978", "type": "external" } ], "gene_names_uniprotkb": "Or1f27", "gene_names_refseq": "Olr1374; Or1f27", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 1374; olfactory receptor Olr1374; olfactory receptor gene Olr1374", "tax_id": 10116, "disease": "", "pathway": " (rno:405333)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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Rimklb", "organism": "Rat", "refseq_name": "beta-citrylglutamate synthase B", "refseq_ac": [ { "id": "NP_001414785", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001414785", "type": "external" } ], "gene_names_uniprotkb": "Rimklbl1; Rimklb; LOC100362344; Rimklbl1", "gene_names_refseq": "Fam80b; Naags; RGD1560851; Rimklb", "protein_names_uniprotkb": "N-acetylaspartylglutamate synthase; 6.3.2.41", "protein_names_refseq": "N-acetylaspartyl-glutamate synthetase; beta-citrylglutamate synthase B; family with sequence similarity 80, member B; ribosomal protein S6 modification-like protein B", "tax_id": 10116, "disease": "", "pathway": " (rno:100362344); (rno:362428); (R-RNO-8964539)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.3.2.41", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.41", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0072590 N-acetyl-L-aspartate-L-glutamate ligase activity;GO:0072591 citrate-L-glutamate ligase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6A4B6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6A4F4-1", "uniprot_id": [ { "id": "A0A8I6A4F4_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6A4F4", "type": "external" } ], "mass": 11357.0, "length": 100, "protein_name": "Similar to human chromosome 2 open reading frame 66", "gene_name": "C9h2orf66", "organism": "Rat", "refseq_name": "similar to human chromosome 2 open reading frame 66 precursor", "refseq_ac": [ { "id": "NP_001420272", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001420272", "type": "external" } ], "gene_names_uniprotkb": "C9h2orf66; LOC686030", "gene_names_refseq": "C9h2orf66", "protein_names_uniprotkb": "Similar to human chromosome 2 open reading frame 66", "protein_names_refseq": "similar to human chromosome 2 open reading frame 66 precursor; uncharacterized protein C2orf66 homolog", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6A4F4-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6A4W3-1", "uniprot_id": [ { "id": "A0A8I6A4W3_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6A4W3", "type": "external" } ], "mass": 20932.0, "length": 192, "protein_name": "Pre-rRNA-processing protein TSR2 homolog", "gene_name": "Tsr2", "organism": "Rat", "refseq_name": "pre-rRNA-processing protein TSR2 homolog", "refseq_ac": [ { "id": "NP_001108499", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108499", "type": "external" } ], "gene_names_uniprotkb": "Tsr2", "gene_names_refseq": "RGD1562416; Tsr2", "protein_names_uniprotkb": "Pre-rRNA-processing protein TSR2 homolog", "protein_names_refseq": "TSR2, 20S rRNA accumulation, homolog; pre-rRNA-processing protein TSR2 homolog", "tax_id": 10116, "disease": "Diamond-Blackfan anemia 14 with mandibulofacial dysostosis (Disease Ontology:DOID:0111897)", "pathway": " (rno:317418)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in 20S pre-rRNA processing., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006364 rRNA processing;GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6A4W3-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6A504-1", "uniprot_id": [ { "id": "A0A8I6A504_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6A504", "type": "external" } ], "mass": 225371.0, "length": 1994, "protein_name": "Zinc finger, C3H1-type containing", "gene_name": "Zfc3h1", "organism": "Rat", "refseq_name": "zinc finger C3H1 domain-containing protein", "refseq_ac": [ { "id": "NP_001419292", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001419292", "type": "external" } ], "gene_names_uniprotkb": "Zfc3h1", "gene_names_refseq": "Psrc2; 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Sblf; Ston1", "protein_names_uniprotkb": "Stonin-1", "protein_names_refseq": "stoned B-like factor; stoned B/TFIIA-alpha/beta-like factor; stonin-1", "tax_id": 10116, "disease": "", "pathway": " (rno:360202); (R-RNO-8856825); (R-RNO-8856828)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "May be involved in the endocytic machinery., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035615 clathrin adaptor activity;GO:0140312 cargo adaptor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0030122 AP-2 adaptor complex;GO:0008021 synaptic vesicle;GO:0030121 AP-1 adaptor complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0030100 regulation of endocytosis;GO:0072583 clathrin-dependent endocytosis;GO:0048488 synaptic vesicle endocytosis;GO:0006897 endocytosis;GO:0048041 focal adhesion assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8I6A974-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6AA84-1", "uniprot_id": [ { "id": "A0A8I6AA84_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6AA84", "type": "external" } ], "mass": 65205.0, "length": 621, "protein_name": "Ankyrin repeat domain 10", "gene_name": "Ankrd10", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ankrd10", "gene_names_refseq": "", "protein_names_uniprotkb": "Ankyrin repeat domain 10", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6AA84-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6AAG7-1", "uniprot_id": [ { "id": "A0A8I6AAG7_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6AAG7", "type": "external" } ], "mass": 101291.0, "length": 920, "protein_name": "Cadherin domain-containing protein", "gene_name": "Pcdhga7", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pcdhga7", "gene_names_refseq": "", "protein_names_uniprotkb": "Cadherin domain-containing protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6AAG7-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6AAI9-1", "uniprot_id": [ { "id": "A0A8I6AAI9_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6AAI9", "type": "external" } ], "mass": 11460.0, "length": 103, "protein_name": "ATP synthase F(0) complex subunit g, mitochondrial", "gene_name": "Atp5mgl3", "organism": "Rat", "refseq_name": "ATP synthase subunit g, mitochondrial-like", "refseq_ac": [ { "id": "XP_038934107", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_038934107", "type": "external" } ], "gene_names_uniprotkb": "Atp5mgl3; LOC679690", "gene_names_refseq": "Atp5mgl3", "protein_names_uniprotkb": "ATP synthase F(0) complex subunit g, mitochondrial; ATPase subunit g", "protein_names_refseq": "ATP synthase subunit g, mitochondrial-like", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (rno:679690)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Subunit g, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. 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"go_biological_process": "GO:0006974 DNA damage response;GO:2000779 regulation of double-strand break repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6AEL7-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6AET2-1", "uniprot_id": [ { "id": "A0A8I6AET2_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6AET2", "type": "external" } ], "mass": 20656.0, "length": 186, "protein_name": "Cytochrome c oxidase assembly protein COX20, mitochondrial", "gene_name": "ENSRNOG00000070717", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ENSRNOG00000070717", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytochrome c oxidase assembly protein COX20, mitochondrial", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0033617 mitochondrial respiratory chain complex IV assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6AET2-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6AEV8-1", "uniprot_id": [ { "id": "A0A8I6AEV8_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6AEV8", "type": "external" } ], "mass": 10215.0, "length": 86, "protein_name": "BolA-like protein 2", "gene_name": "Bola2l2; Bola2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Bola2l2; Bola2; Bola2-ps1; Bola2; RGD1565363", "gene_names_refseq": "", "protein_names_uniprotkb": "BolA-like protein 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:502367)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins. Acts together with the monothiol glutaredoxin GLRX3., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051537 2 iron, 2 sulfur cluster binding;GO:0051536 iron-sulfur cluster binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:1990229 iron-sulfur cluster assembly complex", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0006879 intracellular iron ion homeostasis;GO:0045454 cell redox homeostasis;GO:0051604 protein maturation;GO:0044571 [2Fe-2S] cluster assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6AEV8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6AF64-1", "uniprot_id": [ { "id": "A0A8I6AF64_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6AF64", "type": "external" } ], "mass": 22511.0, "length": 214, "protein_name": "Guanine nucleotide-binding protein subunit gamma", "gene_name": "Gng4", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gng4", "gene_names_refseq": "", "protein_names_uniprotkb": "Guanine nucleotide-binding protein subunit gamma", "protein_names_refseq": "", "tax_id": 10116, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (R-RNO-1296041); (R-RNO-202040); (R-RNO-381676); (R-RNO-392170); (R-RNO-392451); (R-RNO-400042); (R-RNO-4086398); (R-RNO-416476); (R-RNO-418594); (R-RNO-418597); (R-RNO-420092); (R-RNO-428930); (R-RNO-432040); (R-RNO-456926); (R-RNO-8964616); (R-RNO-9856530); (R-RNO-997272)", "pathway_count": 17, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031681 G-protein beta-subunit binding", "go_cellular_component": "GO:0045202 synapse;GO:0005834 heterotrimeric G-protein complex", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0030308 negative regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6AF64-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6AF69-1", "uniprot_id": [ { "id": "A0A8I6AF69_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6AF69", "type": "external" } ], "mass": 35455.0, "length": 311, "protein_name": "Olfactory receptor", "gene_name": "Or4c114", "organism": "Rat", "refseq_name": "olfactory receptor Olr674", "refseq_ac": [ { "id": "NP_001000352", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001000352", "type": "external" } ], "gene_names_uniprotkb": "Or4c114", "gene_names_refseq": "Olr674; Or4c114", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 674; olfactory receptor Olr674; olfactory receptor gene Olr674", "tax_id": 10116, "disease": "", "pathway": " (rno:295881)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6AF69-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6AFN2-1", "uniprot_id": [ { "id": "A0A8I6AFN2_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6AFN2", "type": "external" } ], "mass": 12195.0, "length": 110, "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein", "gene_name": "Uba52l1", "organism": "Rat", "refseq_name": "similar to ubiquitin A-52 residue ribosomal protein fusion product 1", "refseq_ac": [ { "id": "NP_001333294", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333294", "type": "external" } ], "gene_names_uniprotkb": "Uba52l1; RGD1562196", "gene_names_refseq": "RGD1562196; Uba52l1", "protein_names_uniprotkb": "Ubiquitin-ribosomal protein eL40 fusion protein; Ubiquitin A-52 residue ribosomal protein fusion product 1", "protein_names_refseq": "similar to ubiquitin A-52 residue ribosomal protein fusion product 1", "tax_id": 10116, "disease": "", "pathway": " (rno:365873)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005634 nucleus;GO:0005741 mitochondrial outer membrane;GO:0005840 ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6AFN2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6AFP0-1", "uniprot_id": [ { "id": "A0A8I6AFP0_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6AFP0", "type": "external" } ], "mass": 134474.0, "length": 1161, "protein_name": "WASH complex subunit 5", "gene_name": "Washc5", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Washc5; RGD1564420", "gene_names_refseq": "", "protein_names_uniprotkb": "WASH complex subunit 5; WASH complex subunit strumpellin", "protein_names_refseq": "", "tax_id": 10116, "disease": "Ritscher-Schinzel syndrome 1 (Disease Ontology:DOID:0060571); hereditary spastic paraplegia 8 (Disease Ontology:DOID:0110823)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005768 endosome;GO:0005769 early endosome;GO:0005829 cytosol;GO:0043025 neuronal cell body;GO:0071203 WASH complex", "go_biological_process": "GO:0051125 regulation of actin nucleation;GO:0010976 positive regulation of neuron projection development;GO:0007032 endosome organization;GO:0007040 lysosome organization;GO:0016197 endosomal transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6AFP0-1", "record_type": "protein", "filter_code": "0000000.0000010.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6AFW4-1", "uniprot_id": [ { "id": "A0A8I6AFW4_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6AFW4", "type": "external" } ], "mass": 98351.0, "length": 880, "protein_name": "ATP-dependent RNA helicase", "gene_name": "Ddx24", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ddx24; LOC100909476", "gene_names_refseq": "", "protein_names_uniprotkb": "ATP-dependent RNA helicase; 3.6.4.13", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:373065)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "ATP-dependent RNA helicase that plays a role in various aspects of RNA metabolism including pre-mRNA splicing and is thereby involved in different biological processes such as cell cycle regulation or innate immunity. Plays an inhibitory role in TP53 transcriptional activity and subsequently in TP53 controlled cell growth arrest and senescence by inhibiting its EP300 mediated acetylation. Negatively regulates cytosolic RNA-mediated innate immune signaling at least in part by affecting RIPK1/IRF7 interactions. Alternatively, possesses antiviral activity by recognizing gammaherpesvirus transcripts in the context of lytic reactivation. 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