[ { "uniprot_canonical_ac": "Q8BWQ1-1", "uniprot_id": [ { "id": "UD2A3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BWQ1", "type": "external" } ], "mass": 61119.0, "length": 534, "protein_name": "UDP-glucuronosyltransferase 2A3", "gene_name": "Ugt2a3", "organism": "Mouse", "refseq_name": "UDP-glucuronosyltransferase 2A3 precursor", "refseq_ac": [ { "id": "NP_082370", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082370", "type": "external" } ], "gene_names_uniprotkb": "Ugt2a3", "gene_names_refseq": "2010321J07Rik; Ugt2a3", "protein_names_uniprotkb": "UDP-glucuronosyltransferase 2A3; 2.4.1.17; UDPGT 2A3", "protein_names_refseq": "UDP-glucuronosyltransferase 2A3 precursor; UDP-glucuronosyltransferase 2A3; UDPGT 2A3", "tax_id": 10090, "disease": "", "pathway": " (mmu:72094); (R-MMU-156588); (R-MMU-9749641)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "17050650;23806337;27802388;30084848;34428180;37453647", "class_list": "glycogene;glycosyltransferase", "function": "UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions by conjugating glucuronic acid to lipophilic substrates, thereby increasing their water solubility and facilitating excretion. Catalyzes the glucuronidation of the bile acids hyodeoxycholic acid, deoxycholic acid, chenodeoxycholic acid, and ursodeoxycholic acid., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 40, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8R129;Q9D811", "ec_number_list": [ { "id": "2.4.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.17", "type": "external" }, { "id": "2.4.1.170", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.170", "type": "external" }, { "id": "2.4.1.185", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.185", "type": "external" } ], "go_molecular_function": "GO:0015020 glucuronosyltransferase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006805 xenobiotic metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BWQ1-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C1R0-1", "uniprot_id": [ { "id": "TSSK5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C1R0", "type": "external" } ], "mass": 42234.0, "length": 372, "protein_name": "Testis-specific serine/threonine-protein kinase 5", "gene_name": "Tssk5", "organism": "Mouse", "refseq_name": "testis-specific serine/threonine-protein kinase 5", "refseq_ac": [ { "id": "NP_898922", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_898922", "type": "external" } ], "gene_names_uniprotkb": "Tssk5", "gene_names_refseq": "1700091F14Rik; TSK-5; Tssk5", "protein_names_uniprotkb": "Testis-specific serine/threonine-protein kinase 5; 2.7.11.1; TSK-5; TSSK-5; Testis-specific kinase 5", "protein_names_refseq": "testis-specific kinase 5; testis-specific serine/threonine-protein kinase 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:73542)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in a signaling pathway during male germ cell development or mature sperm function., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1WWK7", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8C1R0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C1W1-1", "uniprot_id": [ { "id": "VASH1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C1W1", "type": "external" } ], "mass": 41875.0, "length": 375, "protein_name": "Tubulinyl-Tyr carboxypeptidase 1", "gene_name": "Vash1", "organism": "Mouse", "refseq_name": "tubulinyl-Tyr carboxypeptidase 1", "refseq_ac": [ { "id": "NP_796328", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796328", "type": "external" } ], "gene_names_uniprotkb": "Vash1; Vash", "gene_names_refseq": "D930046M13Rik; G630009D10Rik; TTCP 1; Vash1", "protein_names_uniprotkb": "Tubulinyl-Tyr carboxypeptidase 1; 3.4.17.17; TTCP 1; Tyrosine carboxypeptidase 1; Vasohibin-1", "protein_names_refseq": "tubulinyl-Tyr carboxypeptidase 1; tyrosine carboxypeptidase 1", "tax_id": 10090, "disease": "portal hypertension (Disease Ontology:DOID:10762); liver cirrhosis (Disease Ontology:DOID:5082)", "pathway": " (mmu:238328)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "16473886;16707096;19204325;26794318;29146868;31091125;31815666;33441910;35180473", "class_list": "", "function": "Data support the hypothesis that vasohibin acts as a negative feedback regulator of neovascularization in the retina and suggest that suppression of VEGF receptor 2 may play some role in mediating its activity, [RefSeq, PubMed]; Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function (PubMed:29146868). Acts as an angiogenesis inhibitor: inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis (PubMed:19204325). This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; VASH1 expression could have protective effects on cisplatin-induced AKI probably by maintaining the number and function of peritubular capillaries., [RefSeq, PubMed]; Vasohibin has an activity to prevent neointimal formation by inhibiting adventitial angiogenesis, [RefSeq, PubMed]; Vasohibin-1 has alpha-tubulin detyrosinating activity in glomerular podocytes., [RefSeq, PubMed]; Vasohibin-1 rescues erectile function through up-regulation of angiogenic factors in the diabetic mice. Publication Status: Online-Only, [RefSeq, PubMed]; Vasohibin1, a new mouse cardiomyocyte IRES trans-acting factor that regulates translation in early hypoxia. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QKT9;Q8C394", "ec_number_list": [ { "id": "3.4.17.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.17", "type": "external" } ], "go_molecular_function": "GO:0003779 actin binding;GO:0004181 metallocarboxypeptidase activity;GO:0106423 tubulin-tyrosine carboxypeptidase", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0045177 apical part of cell", "go_biological_process": "GO:1901491 negative regulation of lymphangiogenesis;GO:0001525 angiogenesis;GO:0006508 proteolysis;GO:0010628 positive regulation of gene expression;GO:0009611 response to wounding", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8C1W1-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C5U9-1", "uniprot_id": [ { "id": "UBQL3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C5U9", "type": "external" } ], "mass": 70753.0, "length": 658, "protein_name": "Ubiquilin-3", "gene_name": "Ubqln3", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ubqln3", "gene_names_refseq": "", "protein_names_uniprotkb": "Ubiquilin-3", "protein_names_refseq": "", "tax_id": 10090, "disease": "amyotrophic lateral sclerosis (Disease Ontology:DOID:332)", "pathway": " (mmu:244178)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "25776854", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031593 polyubiquitin modification-dependent protein binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8C5U9-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8JZZ0-1", "uniprot_id": [ { "id": "UD3A2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8JZZ0", "type": "external" } ], "mass": 59673.0, "length": 523, "protein_name": "UDP-glycosyltransferase 3A2", "gene_name": "Ugt3a2", "organism": "Mouse", "refseq_name": "UDP-glucuronosyltransferase 3A2 isoform 1 precursor", "refseq_ac": [ { "id": "NP_659094", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659094", "type": "external" } ], "gene_names_uniprotkb": "Ugt3a2", "gene_names_refseq": "Ugt3a1; Ugt3a2", "protein_names_uniprotkb": "UDP-glycosyltransferase 3A2; 2.4.1.170; 2.4.1.185; UDPGT 3A2", "protein_names_refseq": "UDP glucuronosyltransferase 3 family, polypeptide A2; UDP glycosyltransferases 3 family, polypeptide A2; UDP-glucuronosyltransferase 3A2 isoform 1 precursor; UDP-glucuronosyltransferase 3A2; UDPGT 3A2", "tax_id": 10090, "disease": "", "pathway": " (mmu:223337); (R-MMU-156588); (R-MMU-9749641)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;17050650;22621930;34428180;37453647;40997131", "class_list": "glycogene;glycosyltransferase", "function": "Involved in biotransformation reactions in which lipophilic substrates are conjugated with sugars or sugar derivatives to increase water solubility and enhance excretion. Such reactions are of major importance in the elimination of potentially toxic xenobiotics and endogenous compounds. UGT3A2 catalyzes the addition of sugar residues from UDP-glucose and UDP-xylose to a broad range of acceptor substrates including 4-methylumbelliferone, 1-hydroxypyrene, bioflavones, and estrogens. It has negligible activity toward bile acids and androgens. To a lesser extent, is also able to use UDP-galactose but is inactive with UDP-glucuronic acid as sugar donors (By similarity). Has no activity with UDP-N-acetylglucosamine as the sugar donor (PubMed:22621930)., [UniProtKB, UniProtKB, PubMed]; Mouse Ugt3a2 was able to conjugate 4-methylumbelliferone and ursodeoxycholic acid with UDP-Glc, although to a lesser extent than Ugt3a1, and it was also inactive with UDP-GlcNAc., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 107, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A1A4B4;Q3UP49;Q8VC11", "ec_number_list": [ { "id": "2.4.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.17", "type": "external" }, { "id": "2.4.1.170", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.170", "type": "external" }, { "id": "2.4.1.185", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.185", "type": "external" } ], "go_molecular_function": "GO:0008194 UDP-glycosyltransferase activity;GO:0015020 glucuronosyltransferase activity", "go_cellular_component": "GO:0043541 UDP-N-acetylglucosamine transferase complex", "go_biological_process": "GO:0071412 cellular response to genistein", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8JZZ0-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000000000.100.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K0T7-1", "uniprot_id": [ { "id": "UN13C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K0T7", "type": "external" } ], "mass": 249844.0, "length": 2210, "protein_name": "Protein unc-13 homolog C", "gene_name": "Unc13c", "organism": "Mouse", "refseq_name": "protein unc-13 homolog C", "refseq_ac": [ { "id": "NP_001074622", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074622", "type": "external" } ], "gene_names_uniprotkb": "Unc13c", "gene_names_refseq": "1500037O19Rik; D9Ertd414e; Munc13-3; Unc13c; Unc13h3", "protein_names_uniprotkb": "Protein unc-13 homolog C; Munc13-3", "protein_names_refseq": "protein unc-13 homolog C; unc13 homolog 3", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:208898)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;11150314;22299025;24129315", "class_list": "", "function": "May play a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. May be involved in the regulation of synaptic transmission at parallel fiber - Purkinje cell synapses., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9718, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005543 phospholipid binding;GO:0008270 zinc ion binding;GO:0005509 calcium ion binding;GO:0019905 syntaxin binding", "go_cellular_component": "GO:0044305 calyx of Held;GO:0005886 plasma membrane;GO:0031594 neuromuscular junction;GO:0043195 terminal bouton;GO:0030672 synaptic vesicle membrane", "go_biological_process": "GO:0007268 chemical synaptic transmission;GO:0035249 synaptic transmission, glutamatergic;GO:0016079 synaptic vesicle exocytosis;GO:0031914 negative regulation of synaptic plasticity;GO:0016082 synaptic vesicle priming", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8K0T7-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K2T4-1", "uniprot_id": [ { "id": "UQCC3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K2T4", "type": "external" } ], "mass": 9584.0, "length": 89, "protein_name": "Ubiquinol-cytochrome-c reductase complex assembly factor 3", "gene_name": "Uqcc3", "organism": "Mouse", "refseq_name": "ubiquinol-cytochrome-c reductase complex assembly factor 3", "refseq_ac": [ { "id": "NP_001153828", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153828", "type": "external" } ], "gene_names_uniprotkb": "Uqcc3", "gene_names_refseq": "Cbp4; Uqcc3", "protein_names_uniprotkb": "Ubiquinol-cytochrome-c reductase complex assembly factor 3", "protein_names_refseq": "UPF0723 protein C11orf83 homolog; ubiquinol-cytochrome-c reductase complex assembly factor 3", "tax_id": 10090, "disease": "mitochondrial complex III deficiency nuclear type 9 (Disease Ontology:DOID:0080118)", "pathway": " (mmu:107197)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17170114;34428180;35977508", "class_list": "", "function": "Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex. Thereby, plays an important role in ATP production by mitochondria. Cardiolipin-binding protein, it may also control the cardiolipin composition of mitochondria membranes and their morphology., [UniProtKB, UniProtKB]; The eIF2 kinase pathway induces both pro-survival and pro-apoptotic pathways., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0070300 phosphatidic acid binding;GO:1901612 cardiolipin binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005829 cytosol", "go_biological_process": "GO:0006754 ATP biosynthetic process;GO:0042407 cristae formation;GO:0034551 mitochondrial respiratory chain complex III assembly;GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8K2T4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VIH9-1", "uniprot_id": [ { "id": "UR2R_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VIH9", "type": "external" } ], "mass": 42523.0, "length": 385, "protein_name": "Urotensin-2 receptor", "gene_name": "Uts2r", "organism": "Mouse", "refseq_name": "urotensin-2 receptor", "refseq_ac": [ { "id": "NP_663415", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663415", "type": "external" } ], "gene_names_uniprotkb": "Uts2r; Gpr14", "gene_names_refseq": "Gpr14; UR-2-R; UTR2; UTR; Uts2r", "protein_names_uniprotkb": "Urotensin-2 receptor; G protein-coupled receptor 14; UR-2-R; UR-II-R; Urotensin II receptor", "protein_names_refseq": "G protein-coupled receptor 14; UR-II-R; urotensin II receptor; urotensin-2 receptor", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); hypertension (Disease Ontology:DOID:10763); endomyocardial fibrosis (Disease Ontology:DOID:12932); acute kidney failure (Disease Ontology:DOID:3021); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (mmu:217369); (R-MMU-375276); (R-MMU-416476)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "11976263;12770952;16325305;18710417;19323985;19696412;29133126;30084848;30353214;36167277;38631407", "class_list": "", "function": "Elevated expression of Uts2r in skeletal muscle of diabetic mouse is repoted., [RefSeq, PubMed]; G protein-coupled receptor for the vasoactive neuropeptides urotensin-2 and urotensin-2B. Upon ligand binding, activates intracellular signaling cascades via G protein coupling, primarily through Gq/11, leading to phospholipase C activation, increased intracellular calcium, and activation of protein kinase C (PKC). Through coupling to G(i)/G(o) alpha subunits, stimulates MAPK/ERK pathways and thereby contributes to regulation of vascular tone, cardiac contractility, and cell proliferation. Ligand binding also triggers a marked reduction in the biogenesis of autophagosomes by inhibiting the recruitment of ATG16L1 to pre-autophagosomal endocytic vesicles., [UniProtKB, UniProtKB]; In the CNS Utsr mRNAs are expressed in brainstem and spinal motoneurons,the medial vestibular nucleus, locus coeruleus and the ventral medulla.In periphery,mRNAs are expressed in skeletal muscle, testis, vagina, stomach, and gall bladder,prostate., [RefSeq, PubMed]; Role of urotensin-II and its receptors in sepsis-induced lung injury under diabetic conditions, [RefSeq, PubMed]; The results of this study help to understand the inflammatory and therapeutic contribution of the UII/UTR system on sepsis-induced lung damage. We can suggest that UTR receptor antagonists may be evaluated as a potential drug which reduces sepsis-induced lung damage in the future., [RefSeq, PubMed]; The up-regulation of vascular U-II receptor (UT), GPR14 might be involved in the pathogenesis of atherosclerosis., [RefSeq, PubMed]; Urotensin II receptor deficiency ameliorates ligation-induced carotid intimal hyperplasia partially through the RhoA-YAP1 pathway., [RefSeq, PubMed]; Urotensin II receptor knockout mice on an ApoE knockout background fed a high-fat diet exhibit an enhanced hyperlipidemic and atherosclerotic phenotype., [RefSeq, PubMed]; Urotensin receptor acts as a novel target for ameliorating fasting-induced skeletal muscle atrophy., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001604 urotensin II receptor activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0055037 recycling endosome", "go_biological_process": "GO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007218 neuropeptide signaling pathway;GO:0030307 positive regulation of cell growth;GO:0045777 positive regulation of blood pressure", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8VIH9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99K46-1", "uniprot_id": [ { "id": "UBP11_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99K46", "type": "external" } ], "mass": 105384.0, "length": 921, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 11", "gene_name": "Usp11", "organism": "Mouse", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 11 isoform 1", "refseq_ac": [ { "id": "NP_663603", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663603", "type": "external" } ], "gene_names_uniprotkb": "Usp11", "gene_names_refseq": "6230415D12Rik; Usp11; mKIAA4085", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 11; 3.4.19.12; Deubiquitinating enzyme 11; Ubiquitin thioesterase 11; Ubiquitin-specific-processing protease 11", "protein_names_refseq": "deubiquitinating enzyme 11; ubiquitin carboxyl-terminal hydrolase 11 isoform 1; ubiquitin carboxyl-terminal hydrolase 11; ubiquitin thioesterase 11; ubiquitin thiolesterase 11; ubiquitin-specific-processing protease 11", "tax_id": 10090, "disease": "", "pathway": " (mmu:236733); (R-MMU-5689880)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "12084015;22645316;22773947;34203471;34428180;36822452;38364946", "class_list": "", "function": "Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains (in vitro). Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks. Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex. Promotes cell proliferation by deubiquitinating phosphorylated E2F1., [UniProtKB, UniProtKB]; Structural and functional characterization of the USP11 deubiquitinating enzyme, [RefSeq, PubMed]; USP11 Exacerbates Radiation-Induced Pneumonitis by Activating Endothelial Cell Inflammatory Response via OTUD5-STING Signaling., [RefSeq, PubMed]; USP11 augments TGFbeta signalling by deubiquitylating ALK5., [RefSeq, PubMed]; USP11 plays a critical role in the onset and progression of acute graft-versus-host diseaseNovel target for precision therapeutics., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B1AXB2;Q3TLG5", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" } ], "go_molecular_function": "GO:0004197 cysteine-type endopeptidase activity;GO:0004843 cysteine-type deubiquitinase activity;GO:0001222 transcription corepressor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005694 chromosome", "go_biological_process": "GO:0006508 proteolysis;GO:0016579 protein deubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q99K46-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQ84-1", "uniprot_id": [ { "id": "UBL4B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQ84", "type": "external" } ], "mass": 20518.0, "length": 188, "protein_name": "Ubiquitin-like protein 4B", "gene_name": "Ubl4b", "organism": "Mouse", "refseq_name": "ubiquitin-like protein 4B", "refseq_ac": [ { "id": "NP_080537", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080537", "type": "external" } ], "gene_names_uniprotkb": "Ubl4b", "gene_names_refseq": "4930522D07Rik; Ubl4b", "protein_names_uniprotkb": "Ubiquitin-like protein 4B", "protein_names_refseq": "ubiquitin-like protein 4B", "tax_id": 10090, "disease": "", "pathway": " (mmu:67591)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16872915", "class_list": "", "function": "Ubl4b, a retrogene derived from Ubl4a (X-linked), is specifically expressed in post-meiotic germ cells in mammals., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5RL34", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CQ84-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CR68-1", "uniprot_id": [ { "id": "UCRI_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CR68", "type": "external" } ], "mass": 29368.0, "length": 274, "protein_name": "Cytochrome b-c1 complex subunit Rieske, mitochondrial", "gene_name": "Uqcrfs1", "organism": "Mouse", "refseq_name": "cytochrome b-c1 complex subunit Rieske, mitochondrial", "refseq_ac": [ { "id": "NP_079986", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079986", "type": "external" } ], "gene_names_uniprotkb": "Uqcrfs1", "gene_names_refseq": "4430402G14Rik; Uqcrfs1", "protein_names_uniprotkb": "Cytochrome b-c1 complex subunit Rieske, mitochondrial; 7.1.1.8; 8 kDa subunit 9; Complex III subunit 5; Complex III subunit IX; Cytochrome b-c1 complex subunit 11; Cytochrome b-c1 complex subunit 5; RISP; Rieske iron-sulfur protein; Rieske protein UQCRFS1; UQCRFS1 MTS; UQCRFS1 mitochondrial targeting sequence; Ubiquinol-cytochrome c reductase 8 kDa protein; Ubiquinol-cytochrome c reductase iron-sulfur subunit", "protein_names_refseq": "RISP; Rieske protein UQCRFS1; complex III subunit 5; cytochrome b-c1 complex subunit 5; cytochrome b-c1 complex subunit Rieske, mitochondrial; rieske iron-sulfur protein; ubiquinol-cytochrome c reductase iron-sulfur subunit", "tax_id": 10090, "disease": "mitochondrial complex III deficiency (Disease Ontology:DOID:0111139); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (mmu:66694); (R-MMU-611105); (R-MMU-9865881)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "19026783;25605945;26495903;26740625;28011936;28673544;30084848;33300544;34428180;34616041;35820727;36288343;37453647;38575788;39927985", "class_list": "", "function": "Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII). UQCRFS1 undergoes proteolytic processing once it is incorporated in the complex III dimer. One of the fragments, called subunit 9, corresponds to its mitochondrial targeting sequence (MTS). The proteolytic processing is necessary for the correct insertion of UQCRFS1 in the complex III dimer, but the persistence of UQCRFS1-derived fragments may prevent newly imported UQCRFS1 to be processed and assembled into complex III and is detrimental for the complex III structure and function., [UniProtKB, PubMed]; Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. The Rieske protein is a catalytic core subunit containing a [2Fe-2S] iron-sulfur cluster. It cycles between 2 conformational states during catalysis to transfer electrons from the quinol bound in the Q(0) site in cytochrome b to cytochrome c1. Incorporation of UQCRFS1 is the penultimate step in complex III assembly., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5SVV1", "ec_number_list": [ { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "7.1.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.8", "type": "external" }, { "id": "2.8.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.1.7", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0044877 protein-containing complex binding;GO:0051537 2 iron, 2 sulfur cluster binding;GO:0016491 oxidoreductase activity;GO:0008121 quinol-cytochrome-c reductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0043209 myelin sheath;GO:0045275 respiratory chain complex III", "go_biological_process": "GO:0009725 response to hormone;GO:0009410 response to xenobiotic stimulus;GO:0022904 respiratory electron transport chain;GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9CR68-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CWU6-1", "uniprot_id": [ { "id": "UQCC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CWU6", "type": "external" } ], "mass": 34300.0, "length": 295, "protein_name": "Ubiquinol-cytochrome c reductase complex assembly factor 1", "gene_name": "Uqcc1", "organism": "Mouse", "refseq_name": "ubiquinol-cytochrome c reductase complex assembly factor 1 isoform a", "refseq_ac": [ { "id": "NP_061376", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061376", "type": "external" } ], "gene_names_uniprotkb": "Uqcc1; Bfzb; Uqcc", "gene_names_refseq": "2310079L17Rik; 2410003P15Rik; 3110038N19Rik; Bfzb; Bfzp; Cbp3; Uqcc1; Uqcc", "protein_names_uniprotkb": "Ubiquinol-cytochrome c reductase complex assembly factor 1; Basic FGF-repressed Zic-binding protein; Ubiquinol-cytochrome c reductase complex chaperone CBP3 homolog; mbFZb", "protein_names_refseq": "basic FGF repressed, zinc binding protein; basic FGF-repressed Zic-binding protein; ubiquinol-cytochrome c reductase complex assembly factor 1 isoform a; ubiquinol-cytochrome c reductase complex chaperone, CBP3 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:56046)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11118897;21750661;31219806;35820727;35977508", "class_list": "", "function": "Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex) (PubMed:35977508). Involved in cytochrome b translation and/or stability (PubMed:35977508)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ARK1;Q3TET9;Q9CRP2;Q9JK78", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031410 cytoplasmic vesicle;GO:0061671 Cbp3p-Cbp6 complex", "go_biological_process": "GO:0034551 mitochondrial respiratory chain complex III assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CWU6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CZP0-1", "uniprot_id": [ { "id": "UFSP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CZP0", "type": "external" } ], "mass": 23421.0, "length": 217, "protein_name": "Ufm1-specific protease 1", "gene_name": "Ufsp1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ufsp1; D5Ertd655e", "gene_names_refseq": "", "protein_names_uniprotkb": "Ufm1-specific protease 1; 3.4.22.-; UfSP1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:70240)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11239002;17182609;18321862;21750661;34428180", "class_list": "", "function": "Thiol-dependent isopeptidase that specifically mediate the processing of UFM1 precursors as well as the deconjugation of UFM1 from target proteins (PubMed:17182609, PubMed:18321862). Mainly responsible for the maturation of the UFM1 precursor, a prerequisite for conjugation reactions (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0071567 deUFMylase activity;GO:0008234 cysteine-type peptidase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0051604 protein maturation;GO:0071569 protein ufmylation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CZP0-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CZT5-1", "uniprot_id": [ { "id": "VASN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CZT5", "type": "external" } ], "mass": 72261.0, "length": 673, "protein_name": "Vasorin", "gene_name": "Vasn", "organism": "Mouse", "refseq_name": "vasorin precursor", "refseq_ac": [ { "id": "NP_647468", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647468", "type": "external" } ], "gene_names_uniprotkb": "Vasn; Slitl2", "gene_names_refseq": "2610528G05Rik; Atia; Slitl2; Vasn", "protein_names_uniprotkb": "Vasorin; Protein slit-like 2", "protein_names_refseq": "Slit-like 2; protein slit-like 2; vasorin precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:246154)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;15247411;21658601;22426063;30899004;35892191;35945403;36079859;38504496", "class_list": "", "function": "ATIA is an HIF-1 target that regulates mitochondrial redox pathways., [RefSeq, PubMed]; May act as an inhibitor of TGF-beta signaling., [UniProtKB]; Study characterized the expression pattern of Vasn during mouse embryonic development; with various distinct expression domains, results indicate important roles for Vasn e.g., in the developing skeletal system, the kidneys, and the lungs., [RefSeq, PubMed]; Vasorin Deletion in C57BL/6J Mice Induces Hepatocyte Autophagy through Glycogen-Mediated mTOR Regulation. Publication Status: Online-Only, [RefSeq, PubMed]; Vasorin as an actor of bone turnover? Erratum:[J Cell Physiol. 2024 Dec;239(12):e31425. doi: 10.1002/jcp.31425. PMID: 39192537], [RefSeq, PubMed]; Vasorin contributes to lung injury via FABP4-mediated inflammation., [RefSeq, PubMed]; Vasorin plays a critical role in vascular smooth muscle cells and arterial functions., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 6, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q8BJJ0;Q8R2G5", "ec_number_list": [], "go_molecular_function": "GO:0050431 transforming growth factor beta binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0070062 extracellular exosome", "go_biological_process": "GO:0071461 cellular response to redox state;GO:0071456 cellular response to hypoxia;GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway;GO:0010719 negative regulation of epithelial to mesenchymal transition", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q9CZT5-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D2P4-1", "uniprot_id": [ { "id": "URM1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D2P4", "type": "external" } ], "mass": 11323.0, "length": 101, "protein_name": "Ubiquitin-related modifier 1", "gene_name": "Urm1", "organism": "Mouse", "refseq_name": "ubiquitin-related modifier 1", "refseq_ac": [ { "id": "NP_080891", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080891", "type": "external" } ], "gene_names_uniprotkb": "Urm1", "gene_names_refseq": "2900073H19Rik; Urm1", "protein_names_uniprotkb": "Ubiquitin-related modifier 1", "protein_names_refseq": "ubiquitin-related modifier 1 homolog; ubiquitin-related modifier 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:68205)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16046629;33548388", "class_list": "", "function": "Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates., [UniProtKB, HAMAP]; Structural model of the Urm1 protein reveals a secondary structure fold similar to MoaD proteins and ubiquitin., [RefSeq, PubMed]; The emerging roles of ubiquitin-like protein Urm1 in eukaryotes. Review article, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A3KGW2;Q8BHY9", "ec_number_list": [], "go_molecular_function": "GO:0000166 nucleotide binding;GO:0031386 protein tag activity;GO:0097163 sulfur carrier activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0034227 tRNA thio-modification;GO:0002098 tRNA wobble uridine modification;GO:0032447 protein urmylation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D2P4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D593-1", "uniprot_id": [ { "id": "VATE2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D593", "type": "external" } ], "mass": 26307.0, "length": 226, "protein_name": "V-type proton ATPase subunit E 2", "gene_name": "Atp6v1e2", "organism": "Mouse", "refseq_name": "V-type proton ATPase subunit E 2", "refseq_ac": [ { "id": "NP_083397", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083397", "type": "external" } ], "gene_names_uniprotkb": "Atp6v1e2; Atp6e1", "gene_names_refseq": "4930500C14Rik; Atp6e1; Atp6v1e2; E1", "protein_names_uniprotkb": "V-type proton ATPase subunit E 2; V-ATPase subunit E 2; Vacuolar proton pump subunit E 2", "protein_names_refseq": "ATPase, H+ transporting, V1 subunit E-like 2; ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E-like 2; V-ATPase subunit E 2; V-type proton ATPase subunit E 2; vacuolar proton pump subunit E 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:74915); (R-MMU-1222556); (R-MMU-77387); (R-MMU-917977); (R-MMU-9639288); (R-MMU-983712)", "pathway_count": 6, "publication_count": 2, "publication_id_list": "11872743;39695235", "class_list": "", "function": "Novel isoform of V-ATPase E subunit located in the acrosomal membrane of sperm required for acrosome acidification, [RefSeq, PubMed]; Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P8U8;Q810S5", "ec_number_list": [], "go_molecular_function": "GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D593-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EPB8-1", "uniprot_id": [ { "id": "V1R54_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EPB8", "type": "external" } ], "mass": 35854.0, "length": 315, "protein_name": "Vomeronasal type-1 receptor 54", "gene_name": "Vmn1r54", "organism": "Mouse", "refseq_name": "vomeronasal type-1 receptor 54", "refseq_ac": [ { "id": "NP_444454", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444454", "type": "external" } ], "gene_names_uniprotkb": "Vmn1r54; V1ra9", "gene_names_refseq": "V1ra9; VN7; Vmn1r54", "protein_names_uniprotkb": "Vomeronasal type-1 receptor 54; Pheromone receptor VN7; Vomeronasal receptor 7; Vomeronasal type-1 receptor A9", "protein_names_refseq": "pheromone receptor VN7; vomernasal 1 receptor Vmn1r54; vomeronasal 1 receptor, A9; vomeronasal receptor 7; vomeronasal type 1 receptor A9; vomeronasal type-1 receptor 54", "tax_id": 10090, "disease": "", "pathway": " (mmu:113851)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11116090;11752409;12214233;25428506;34428180", "class_list": "", "function": "Putative pheromone receptor implicated in the regulation of social and reproductive behavior., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005550 pheromone binding;GO:0016503 pheromone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9EPB8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQ47-1", "uniprot_id": [ { "id": "V1R44_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EQ47", "type": "external" } ], "mass": 35388.0, "length": 310, "protein_name": "Vomeronasal type-1 receptor 44", "gene_name": "Vmn1r44", "organism": "Mouse", "refseq_name": "vomeronasal type-1 receptor 44", "refseq_ac": [ { "id": "NP_444457", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444457", "type": "external" } ], "gene_names_uniprotkb": "Vmn1r44; V1ra10; V1rb11; V1rb4", "gene_names_refseq": "V1RA10; V1rb11; V1rb4; Vmn1r44", "protein_names_uniprotkb": "Vomeronasal type-1 receptor 44; Vomeronasal type-1 receptor A10; Vomeronasal type-1 receptor B11; Vomeronasal type-1 receptor B4", "protein_names_refseq": "vomernasal 1 receptor Vmn1r44; vomeronasal 1 receptor, B4; vomeronasal receptor 1 A10; vomeronasal receptor V1RB11; vomeronasal type-1 receptor 44; vomeronasal type-1 receptor A10; vomeronasal type-1 receptor B11; vomeronasal type-1 receptor B4", "tax_id": 10090, "disease": "", "pathway": " (mmu:113854)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11116090;11802169;12214233;21750661", "class_list": "", "function": "Putative pheromone receptor implicated in the regulation of social and reproductive behavior., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B9EKS6;Q3B815;Q3B816;Q8R2E5;Q8VIC5", "ec_number_list": [], "go_molecular_function": "GO:0005550 pheromone binding;GO:0016503 pheromone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9EQ47-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JHH2-1", "uniprot_id": [ { "id": "TSN32_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JHH2", "type": "external" } ], "mass": 28906.0, "length": 256, "protein_name": "Tetraspanin-32", "gene_name": "Tspan32", "organism": "Mouse", "refseq_name": "tetraspanin-32 isoform a", "refseq_ac": [ { "id": "NP_001121552", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121552", "type": "external" } ], "gene_names_uniprotkb": "Tspan32; Art1; Phemx; Tssc6", "gene_names_refseq": "Art-1; D7Wsu37e; Phemx; Tspan32; Tssc6", "protein_names_uniprotkb": "Tetraspanin-32; AML1-regulated transmembrane protein 1; Protein Phemx; Tspan-32", "protein_names_refseq": "AML1-regulated transmembrane protein 1; pan hematopoietic expression; protein Phemx; tetraspanin-32 isoform a; tspan-32; tumor-suppressing subchromosomal transferable fragment 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:27027)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10915772;10950922;11396961;11718897;21750661;29178985;36854750", "class_list": "", "function": "Study demonstrates a complementary role between TSSC6 and P2Y12 receptor in platelets in regulating 'outside in' integrin alphaIIbbeta3 signalling thrombus growth and stability., [RefSeq, PubMed]; TSPAN32 suppresses chronic myeloid leukemia pathogenesis and progression by stabilizing PTEN. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q923G9;Q9ESH0;Q9JHQ9;Q9JHR0;Q9JHR1;Q9JHR2;Q9JHS8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0070442 integrin alphaIIb-beta3 complex;GO:0016020 membrane", "go_biological_process": "GO:0007229 integrin-mediated signaling pathway;GO:0008285 negative regulation of cell population proliferation;GO:0007596 blood coagulation;GO:0007010 cytoskeleton organization;GO:0070527 platelet aggregation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9JHH2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QY76-1", "uniprot_id": [ { "id": "VAPB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QY76", "type": "external" } ], "mass": 26946.0, "length": 243, "protein_name": "Vesicle-associated membrane protein-associated protein B", "gene_name": "Vapb", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Vapb", "gene_names_refseq": "", "protein_names_uniprotkb": "Vesicle-associated membrane protein-associated protein B; VAMP-B; VAMP-associated protein 33b; VAMP-associated protein B; VAP-B", "protein_names_refseq": "", "tax_id": 10090, "disease": "amyotrophic lateral sclerosis type 8 (Disease Ontology:DOID:0050752); autosomal dominant adult-onset proximal spinal muscular atrophy (Disease Ontology:DOID:0111194); spinal muscular atrophy (Disease Ontology:DOID:12377); neurodegenerative disease (Disease Ontology:DOID:1289); motor neuron disease (Disease Ontology:DOID:231); amyotrophic lateral sclerosis (Disease Ontology:DOID:332)", "pathway": " (R-MMU-8980692); (R-MMU-9013106); (R-MMU-9013404); (R-MMU-9013408)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "21183079;24251978;28011936;30084848;34428180;36288343;40021952;41129229", "class_list": "", "function": "Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44. Interacts with STARD3 in a FFAT motif phosphorylation dependent manner. Via interaction with WDR44 participates in neosynthesized protein export. Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0019899 enzyme binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0044790 suppression of viral release by host;GO:0044829 host-mediated activation of viral genome replication;GO:0090158 endoplasmic reticulum membrane organization;GO:0046725 negative regulation by virus of viral protein levels in host cell;GO:0036498 IRE1-mediated unfolded protein response", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9QY76-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZ49-1", "uniprot_id": [ { "id": "UBXN8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QZ49", "type": "external" } ], "mass": 31555.0, "length": 277, "protein_name": "UBX domain-containing protein 8", "gene_name": "Ubxn8", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ubxn8; D0H8S2298E; Rep8; Ubxd6", "gene_names_refseq": "", "protein_names_uniprotkb": "UBX domain-containing protein 8; Rep-8 protein; Reproduction 8 protein; UBX domain-containing protein 6", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "21949850;34428180;9931425", "class_list": "", "function": "Involved in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins, possibly by tethering VCP to the endoplasmic reticulum membrane. May play a role in reproduction (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9QZ49-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0P9-1", "uniprot_id": [ { "id": "UCHL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R0P9", "type": "external" } ], "mass": 24838.0, "length": 223, "protein_name": "Ubiquitin carboxyl-terminal hydrolase isozyme L1", "gene_name": "Uchl1", "organism": "Mouse", "refseq_name": "ubiquitin carboxyl-terminal hydrolase isozyme L1", "refseq_ac": [ { "id": "NP_035800", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035800", "type": "external" } ], "gene_names_uniprotkb": "Uchl1", "gene_names_refseq": "PGP 9.5; PGP9.5; UCH-L1; UCHL-1; Uchl1; gad", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase isozyme L1; 3.4.19.12; Neuron cytoplasmic protein 9.5; PGP 9.5; PGP9.5; UCH-L1; Ubiquitin thioesterase L1", "protein_names_refseq": "gracile axonal dystrophy; neuron cytoplasmic protein 9.5; protein gene product 9.5; ubiquitin carboxyl-terminal hydrolase isozyme L1; ubiquitin thioesterase L1", "tax_id": 10090, "disease": "late onset Parkinson's disease (Disease Ontology:DOID:0060892); hereditary spastic paraplegia 79A (Disease Ontology:DOID:0070455); hereditary spastic paraplegia 79B (Disease Ontology:DOID:0112344); Alzheimer's disease (Disease Ontology:DOID:10652); Parkinson's disease (Disease Ontology:DOID:14330); retinal disease (Disease Ontology:DOID:5679); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:22223); (R-MMU-5689603)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10471497;12559414;12913066;14695319;15911766;29959188;31492742;32494592;33137160;37215988", "class_list": "", "function": "Deubiquitinase that plays a role in the regulation of several processes such as maintenance of synaptic function, cardiac function, inflammatory response or osteoclastogenesis (PubMed:31492742, PubMed:32494592, PubMed:37215988). Abrogates the ubiquitination of multiple proteins including WWTR1/TAZ, EGFR, HIF1A and beta-site amyloid precursor protein cleaving enzyme 1/BACE1. In addition, recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin to maintain a stable pool of monoubiquitin that is a key requirement for the ubiquitin-proteasome and the autophagy-lysosome pathways (By similarity). Regulates amyloid precursor protein/APP processing by promoting BACE1 degradation resulting in decreased amyloid beta production (By similarity). Plays a role in the immune response by regulating the ability of MHC I molecules to reach cross-presentation compartments competent for generating Ag-MHC I complexes (PubMed:31492742). Mediates the 'Lys-48'-linked deubiquitination of the transcriptional coactivator WWTR1/TAZ leading to its stabilization and inhibition of osteoclastogenesis (PubMed:37215988). Deubiquitinates and stabilizes epidermal growth factor receptor EGFR to prevent its degradation and to activate its downstream mediators (PubMed:32494592). Modulates oxidative activity in skeletal muscle by regulating key mitochondrial oxidative proteins (PubMed:33137160). Enhances the activity of hypoxia-inducible factor 1-alpha/HIF1A by abrogateing its VHL E3 ligase-mediated ubiquitination and consequently inhibiting its degradation (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9R122", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0030547 signaling receptor inhibitor activity;GO:0008242 omega peptidase activity;GO:0031625 ubiquitin protein ligase binding;GO:0031694 alpha-2A adrenergic receptor binding;GO:0043022 ribosome binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030424 axon", "go_biological_process": "GO:0002931 response to ischemia;GO:0007409 axonogenesis;GO:0008283 cell population proliferation;GO:0016579 protein deubiquitination;GO:0050905 neuromuscular process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9R0P9-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1Z0-1", "uniprot_id": [ { "id": "USO1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z1Z0", "type": "external" } ], "mass": 106983.0, "length": 959, "protein_name": "General vesicular transport factor p115", "gene_name": "Uso1", "organism": "Mouse", "refseq_name": "general vesicular transport factor p115 isoform 2", "refseq_ac": [ { "id": "NP_062363", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062363", "type": "external" } ], "gene_names_uniprotkb": "Uso1; Vdp", "gene_names_refseq": "115kDa; TAP; Uso1; Vdp", "protein_names_uniprotkb": "General vesicular transport factor p115; Protein USO1 homolog; TAP; Transcytosis-associated protein; Vesicle-docking protein", "protein_names_refseq": "USO1 homolog, vesicle docking protein; general vesicular transport factor p115 isoform 2; general vesicular transport factor p115; protein USO1 homolog; transcytosis associated protein p115; transcytosis-associated protein; vesicle docking protein, 115 kDa; vesicle-docking protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:56041); (R-MMU-204005); (R-MMU-6807878)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "17242355;21183079;21750661;23185636;25153642;28528544;30630895;31219806;34428180;36288343;39627609", "class_list": "", "function": "General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity., [UniProtKB, UniProtKB]; Knockdown of GM130 (also known as GOLGA2) or p115 (also known as USO1), two regulators of the early secretory pathway, impairs GC and ERES reorganisation. This in turn results in inhibition of myotube fusion and M-cadherin (also known as CDH15) transport to the sarcolemma. Publication Status: Online-Only, [RefSeq, PubMed]; USO1 deficiency results in Golgi disruption and early embryonic lethality in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T9L9;Q3TH58;Q3U1C7;Q3UMW6;Q91WE7;Q99JZ5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:1900076 regulation of cellular response to insulin stimulus;GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0007264 small GTPase-mediated signal transduction;GO:0061025 membrane fusion", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9Z1Z0-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2C6-1", "uniprot_id": [ { "id": "UPK1B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z2C6", "type": "external" } ], "mass": 29762.0, "length": 260, "protein_name": "Uroplakin-1b", "gene_name": "Upk1b", "organism": "Mouse", "refseq_name": "uroplakin-1b", "refseq_ac": [ { "id": "NP_849255", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_849255", "type": "external" } ], "gene_names_uniprotkb": "Upk1b", "gene_names_refseq": "Tspan20; UPIb; Upk1b; Upk1", "protein_names_uniprotkb": "Uroplakin-1b; UP1b; UPIb; Uroplakin Ib", "protein_names_refseq": "UP1b; uroplakin Ib; uroplakin-1b", "tax_id": 10090, "disease": "", "pathway": " (mmu:22268)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10343097;11718558", "class_list": "", "function": "Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity)., [UniProtKB]; Structure of the major membrane protein complex from urinary bladder epithelial cells by cryoelectron crystallography, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C448;Q8K4M0", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0120001 apical plasma membrane urothelial plaque;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0009617 response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9Z2C6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CY34-1", "uniprot_id": [ { "id": "UB2FA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CY34", "type": "external" } ], "mass": 21110.0, "length": 185, "protein_name": "NEDD8-conjugating enzyme UBE2F", "gene_name": "Ube2f", "organism": "Mouse", "refseq_name": "NEDD8-conjugating enzyme UBE2F", "refseq_ac": [ { "id": "NP_080730", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080730", "type": "external" } ], "gene_names_uniprotkb": "Ube2f; Ube2fa", "gene_names_refseq": "2510010F15Rik; Ube2f", "protein_names_uniprotkb": "NEDD8-conjugating enzyme UBE2F; 2.3.2.34; NEDD8 carrier protein UBE2F; NEDD8 protein ligase UBE2F; NEDD8-conjugating enzyme 2; RING-type E3 NEDD8 transferase UBE2F; Ubiquitin-conjugating enzyme E2 F", "protein_names_refseq": "NEDD8 carrier protein UBE2F; NEDD8 protein ligase UBE2F; NEDD8-conjugating enzyme 2; NEDD8-conjugating enzyme UBE2F; RING-type E3 NEDD8 transferase UBE2F; ubiquitin-conjugating enzyme E2 F", "tax_id": 10090, "disease": "", "pathway": " (mmu:67921); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "19250909;21750661;38574733", "class_list": "", "function": "Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins (PubMed:19250909). Together with the E3 ubiquitin ligase RNF7/RBX2, specifically neddylates cullin-5 (CUL5) (PubMed:19250909, PubMed:38574733). Does not neddylate CUL1, CUL2, CUL3, CUL4A or CUL4B (PubMed:19250909). Mediates neddylation of the CUL9-RBX1 complex (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99JK3;Q9D8K0;Q9D8K7", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "6.2.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.64", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0061654 NEDD8 conjugating enzyme activity;GO:0005524 ATP binding;GO:0019788 NEDD8 transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045116 protein neddylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CY34-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91WM3-1", "uniprot_id": [ { "id": "U3IP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91WM3", "type": "external" } ], "mass": 52107.0, "length": 475, "protein_name": "U3 small nucleolar RNA-interacting protein 2", "gene_name": "Rrp9", "organism": "Mouse", "refseq_name": "U3 small nucleolar RNA-interacting protein 2", "refseq_ac": [ { "id": "NP_663595", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663595", "type": "external" } ], "gene_names_uniprotkb": "Rrp9; Rnu3ip2; U3-55k", "gene_names_refseq": "55kDa; D9Wsu10e; Rnu3ip2; Rrp9; U3-55k", "protein_names_uniprotkb": "U3 small nucleolar RNA-interacting protein 2; RRP9 homolog; U3 small nucleolar ribonucleoprotein-associated 55 kDa protein; U3 snoRNP-associated 55 kDa protein; U3-55K", "protein_names_refseq": "RNA, U3 small nucleolar interacting protein 2; RRP9 homolog; RRP9, small subunit (SSU) processome component, homolog; U3 small nucleolar RNA-interacting protein 2; U3 small nucleolar ribonucleoprotein-associated 55 kDa protein; U3 snoRNP-associated 55-kDa protein; U3 snoRNP-associated protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:27966); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "12448766;17242355;19131326;19144319;19224205;20173027;21183079;21750661;22872234;34203471;34887587;35820727", "class_list": "", "function": "Component of a nucleolar small nuclear ribonucleoprotein particle (snoRNP) thought to participate in the processing and modification of pre-ribosomal RNA (pre-rRNA). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB]; We cloned and sequenced the cDNAs of the mouse PARP-3 (Adprt3) gene encoding poly(ADP-ribose) polymerase 3 and of the closely linked U3-55k gene coding for the U3 small nucleolar ribonucleoprotein complex-associated 55-kilodalton protein., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CFB7", "ec_number_list": [], "go_molecular_function": "GO:0030515 snoRNA binding;GO:0034511 U3 snoRNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0031428 box C/D methylation guide snoRNP complex;GO:0032040 small-subunit processome", "go_biological_process": "GO:0006364 rRNA processing;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q91WM3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80U95-1", "uniprot_id": [ { "id": "UBE3C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80U95", "type": "external" } ], "mass": 123976.0, "length": 1083, "protein_name": "Ubiquitin-protein ligase E3C", "gene_name": "Ube3c", "organism": "Mouse", "refseq_name": "ubiquitin-protein ligase E3C", "refseq_ac": [ { "id": "NP_598668", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598668", "type": "external" } ], "gene_names_uniprotkb": "Ube3c; Kiaa0010; Kiaa10", "gene_names_refseq": "RAUL; Ube3c; mKIAA0010", "protein_names_uniprotkb": "Ubiquitin-protein ligase E3C; 2.3.2.26; HECT-type ubiquitin transferase E3C; RAUL; RTA-associated ubiquitin ligase", "protein_names_refseq": "HECT-type ubiquitin transferase E3C; RTA-associated ubiquitin ligase; ubiquitin-protein ligase E3C", "tax_id": 10090, "disease": "", "pathway": " (mmu:100763); (R-MMU-983168)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "21167755;21750661;28396413;33300544;37173692;37507081", "class_list": "", "function": "E3 ubiquitin-protein ligase that specifically catalyzes 'Lys-29'- and 'Lys-48'-linked polyubiquitin chains (By similarity). Accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity). Associates with the proteasome and promotes elongation of ubiquitin chains on substrates bound to the 26S proteasome (By similarity). Also catalyzes 'Lys-29'- and 'Lys-48'-linked ubiquitination of 26S proteasome subunit ADRM1/RPN13 in response to proteotoxic stress, impairing the ability of the proteasome to bind and degrade ubiquitin-conjugated proteins (By similarity). Acts as a negative regulator of autophagy by mediating 'Lys-29'- and 'Lys-48'-linked ubiquitination of PIK3C3/VPS34, promoting its degradation (By similarity). Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains; with some preference for 'Lys-48' linkages (By similarity). Acts as a negative regulator of type I interferon by mediating 'Lys-48'-linked ubiquitination of IRF3 and IRF7, leading to their degradation by the proteasome (PubMed:21167755). Catalyzes ubiquitination and degradation of CAND2 (By similarity)., [UniProtKB, UniProtKB, PubMed]; LINC00963-FOSB-mediated transcription activation of UBE3C enhances radioresistance of breast cancer cells by inducing ubiquitination-dependent protein degradation of TP73. Publication Status: Online-Only, [RefSeq, PubMed]; Usp14 and Ube3c cycle together on and off proteasomes, and the presence of ubiquitinated substrates promotes their association. This mechanism enables proteasome activity to adapt to the supply of substrates., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VB95;Q8BQZ6;Q8C7W6;Q8CDJ1;Q8VDL5", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0070936 protein K48-linked ubiquitination;GO:0046854 phosphatidylinositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q80U95-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BLH5-1", "uniprot_id": [ { "id": "TSP50_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BLH5", "type": "external" } ], "mass": 48676.0, "length": 439, "protein_name": "Probable threonine protease PRSS50", "gene_name": "Prss50", "organism": "Mouse", "refseq_name": "probable threonine protease PRSS50 isoform 1 precursor", "refseq_ac": [ { "id": "NP_666339", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666339", "type": "external" } ], "gene_names_uniprotkb": "Prss50; Tsp50", "gene_names_refseq": "79H19C; Prss50; Tsp50", "protein_names_uniprotkb": "Probable threonine protease PRSS50; 3.4.25.-; Serine protease 50; Testis-specific protease-like protein 50", "protein_names_refseq": "probable threonine protease PRSS50 isoform 1 precursor; probable threonine protease PRSS50; protease, serine 50; testes-specific protease 50; testis-specific protease-like protein 50", "tax_id": 10090, "disease": "", "pathway": " (mmu:235631)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;12140191;15491742;18662669;21086474;21750661;29842883;33913480;38189580", "class_list": "", "function": "May be involved in proteolysis through its threonine endopeptidase activity., [UniProtKB]; PRSS50 is a testis protease responsible for proper sperm tail formation and function., [RefSeq, PubMed]; Results showed that downregulation of TSP50 expression in P19 embryonal carcinoma stem cells not only reduced cell proliferation, colony formation, and migration but also induced cell apoptosis, [RefSeq, PubMed]; TSP50 Attenuates DSS-Induced Colitis by Regulating TGF-beta Signaling Mediated Maintenance of Intestinal Mucosal Barrier Integrity., [RefSeq, PubMed]; TSP50 expression at embryonic day 6.5 (E6.5), day 8.5 (E8.5) and day 10.5 (E10.5) was increasingly enhanced, However, the expression of TSP50 decreased gradually in the development and differentiation of cardiac myocyte from E12.5 to postnatal (P0)., [RefSeq, PubMed]; TSP50 may perform a critical biologic function in mammalian spermatogenesis. It may be a new type of threonine protease whose linear catalytic structure is similar to many serine proteases, except for a Thr-for-Ser residual catalytic site substitution., [RefSeq, PubMed]; These findings suggested that DNA methylation might regulate the TSP50 and mTSP50 gene expressions in different types of tissues and spermatic cells., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9781, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B2RWS9;Q8K466", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity;GO:0004298 threonine-type endopeptidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis;GO:0016485 protein processing", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8BLH5-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q78JW9-1", "uniprot_id": [ { "id": "UBFD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q78JW9", "type": "external" } ], "mass": 40143.0, "length": 368, "protein_name": "Ubiquitin domain-containing protein UBFD1", "gene_name": "Ubfd1", "organism": "Mouse", "refseq_name": "ubiquitin domain-containing protein UBFD1", "refseq_ac": [ { "id": "NP_613055", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_613055", "type": "external" } ], "gene_names_uniprotkb": "Ubfd1; D7Wsu128e", "gene_names_refseq": "D7Wsu105e; D7Wsu128e; Ubfd1; Ubph", "protein_names_uniprotkb": "Ubiquitin domain-containing protein UBFD1", "protein_names_refseq": "ubiquitin domain-containing protein UBFD1; ubiquitin-binding protein homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:28018)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q78JW9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7M764-1", "uniprot_id": [ { "id": "U17PE_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7M764", "type": "external" } ], "mass": 60219.0, "length": 540, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 17-like protein E", "gene_name": "Usp17le", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Usp17le; Dub3; Dub6; Usp17l2; Usp17", "gene_names_refseq": "", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 17-like protein E; 3.4.19.12; DUB-3; Deubiquitinating enzyme 17-like protein 2; Deubiquitinating protein 3; Deubiquitinating protein 6; USP17-E; Ubiquitin carboxyl-terminal hydrolase 17-like protein 2; Ubiquitin thioesterase 17-like protein 2; Ubiquitin-specific-processing protease 17-like protein 2", "protein_names_refseq": "", "tax_id": 10090, "disease": "congenital heart disease (Disease Ontology:DOID:1682); primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (mmu:625530); (R-MMU-5689880); (R-MMU-9648002)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "12838346;20228808;21750661", "class_list": "", "function": "Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3YU85", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.4.26.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.26.1", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0004843 cysteine-type deubiquitinase activity;GO:0005540 hyaluronic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:1900027 regulation of ruffle assembly;GO:0050691 regulation of defense response to virus by host;GO:0071586 CAAX-box protein processing;GO:0016579 protein deubiquitination;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7M764-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQ37-1", "uniprot_id": [ { "id": "UBE2T_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQ37", "type": "external" } ], "mass": 22975.0, "length": 204, "protein_name": "Ubiquitin-conjugating enzyme E2 T", "gene_name": "Ube2t", "organism": "Mouse", "refseq_name": "ubiquitin-conjugating enzyme E2 T", "refseq_ac": [ { "id": "NP_001265044", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001265044", "type": "external" } ], "gene_names_uniprotkb": "Ube2t", "gene_names_refseq": "2700084L22Rik; Ube2t", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 T; 2.3.2.23; E2 ubiquitin-conjugating enzyme T; Ubiquitin carrier protein T; Ubiquitin-protein ligase T", "protein_names_refseq": "E2 ubiquitin-conjugating enzyme T; ubiquitin carrier protein T; ubiquitin-conjugating enzyme E2 T; ubiquitin-conjugating enzyme E2T (putative); ubiquitin-protein ligase T", "tax_id": 10090, "disease": "Fanconi anemia complementation group T (Disease Ontology:DOID:0111081)", "pathway": " (mmu:67196); (R-MMU-6783310); (R-MMU-8866652)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "18667844;21183079;21750661;25428506;36156329;36928776;37181827", "class_list": "", "function": "Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair: acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination., [UniProtKB, UniProtKB]; Overexpression of UBE2T in NIH3T3 cells significantly promoted colony formation in mouse cell cultures., [RefSeq, PubMed]; UBE2T Promotes Temozolomide Resistance of Glioblastoma Through Regulating the Wnt/beta-Catenin Signaling Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; UBE2T promotes glioblastoma malignancy through ubiquitination-mediated degradation of RPL6., [RefSeq, PubMed]; UBE2T resolves transcription-replication conflicts and protects common fragile sites in primordial germ cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0031625 ubiquitin protein ligase binding;GO:0004842 ubiquitin-protein transferase activity;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0006281 DNA repair;GO:0006974 DNA damage response;GO:0070979 protein K11-linked ubiquitination;GO:0000209 protein polyubiquitination;GO:0051865 protein autoubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9CQ37-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJX7-1", "uniprot_id": [ { "id": "TYDP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JJX7", "type": "external" } ], "mass": 41034.0, "length": 370, "protein_name": "Tyrosyl-DNA phosphodiesterase 2", "gene_name": "Tdp2", "organism": "Mouse", "refseq_name": "tyrosyl-DNA phosphodiesterase 2", "refseq_ac": [ { "id": "NP_062424", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062424", "type": "external" } ], "gene_names_uniprotkb": "Tdp2; Ttrap", "gene_names_refseq": "D13Ertd656e; Tdp2; Ttrap", "protein_names_uniprotkb": "Tyrosyl-DNA phosphodiesterase 2; 3.1.4.-; 5'-Tyr-DNA phosphodiesterase; 5'-tyrosyl-DNA phosphodiesterase; TRAF and TNF receptor-associated protein; Tyr-DNA phosphodiesterase 2", "protein_names_refseq": "5'-Tyr-DNA phosphodiesterase; 5'-tyrosyl-DNA phosphodiesterase; TRAF and TNF receptor-associated protein; tyr-DNA phosphodiesterase 2; tyrosyl-DNA phosphodiesterase 2", "tax_id": 10090, "disease": "autosomal recessive spinocerebellar ataxia 23 (Disease Ontology:DOID:0111613)", "pathway": " (mmu:56196); (R-MMU-5693571)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10764746;20173027;21750661;22740648;23104055;24658003;24808172;26495903;27060144;27099339;29353210", "class_list": "", "function": "DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DNA double-strand breaks/DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation (PubMed:23104055, PubMed:24808172, PubMed:27060144, PubMed:27099339). Thereby, protects the transcription of many genes involved in neurological development and maintenance from the abortive activity of TOP2 (PubMed:22740648). Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DSBs due to DNA damage by radiation and free radicals. Has preference for single-stranded DNA or duplex DNA with a 4 base pair overhang as substrate. Also has 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. Constitutes the major if not only 5'-tyrosyl-DNA phosphodiesterase in cells. Also acts as an adapter by participating in the specific activation of MAP3K7/TAK1 in response to TGF-beta: associates with components of the TGF-beta receptor-TRAF6-TAK1 signaling module and promotes their ubiquitination dependent complex formation. Involved in non-canonical TGF-beta induced signaling routes. May also act as a negative regulator of ETS1 and may inhibit NF-kappa-B activation. Acts as a regulator of ribosome biogenesis following stress (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; EMCV yields are significantly reduced during infection of mouse embryonic fibroblasts genetically ablated for TDP2., [RefSeq, PubMed]; The results collectively provide a structural mechanism for Tdp2 engagement of heterogeneous DNA damage that causes Top2 poisoning., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2RTH9", "ec_number_list": [ { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0030145 manganese ion binding;GO:0004519 endonuclease activity;GO:0008081 phosphoric diester hydrolase activity;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0006302 double-strand break repair;GO:0048666 neuron development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9JJX7-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52482-1", "uniprot_id": [ { "id": "UB2E1_MOUSE", "url": "https://www.uniprot.org/uniprot/P52482", "type": "external" } ], "mass": 21333.0, "length": 193, "protein_name": "Ubiquitin-conjugating enzyme E2 E1", "gene_name": "Ube2e1", "organism": "Mouse", "refseq_name": "ubiquitin-conjugating enzyme E2 E1", "refseq_ac": [ { "id": "NP_033481", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033481", "type": "external" } ], "gene_names_uniprotkb": "Ube2e1; Ubce5; Ubcm3", "gene_names_refseq": "UbcM3; Ubce5; Ube2e1; ubcM2", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 E1; (E3-independent) E2 ubiquitin-conjugating enzyme E1; 2.3.2.23; 2.3.2.24; E2 ubiquitin-conjugating enzyme E1; UbcM3; Ubiquitin carrier protein E1; Ubiquitin-protein ligase E1", "protein_names_refseq": "(E3-independent) E2 ubiquitin-conjugating enzyme E1; E2 ubiquitin-conjugating enzyme E1; ubiquitin carrier protein E1; ubiquitin-conjugating enzyme 5; ubiquitin-conjugating enzyme E2 E1; ubiquitin-conjugating enzyme E2E 1, UBC4/5 homolog; ubiquitin-protein ligase E1", "tax_id": 10090, "disease": "", "pathway": " (mmu:22194); (R-MMU-1169408); (R-MMU-141430); (R-MMU-174048); (R-MMU-174084); (R-MMU-174154); (R-MMU-174178); (R-MMU-174184); (R-MMU-176407); (R-MMU-176408); (R-MMU-176409); (R-MMU-176412); (R-MMU-179409); (R-MMU-2467813); (R-MMU-2559582); (R-MMU-68867); (R-MMU-69017); (R-MMU-8866652); (R-MMU-8866654); (R-MMU-983168)", "pathway_count": 20, "publication_count": 5, "publication_id_list": "21750661;22783725;30282802;31219806;8576256", "class_list": "", "function": "Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. In vitro also catalyzes 'Lys-48'-linked polyubiquitination., [UniProtKB, UniProtKB]; OTUB1 depletion dramatically destabilizes the E2-conjugating enzyme UBE2E1 in both mouse and human OTUB1 knockout cell lines., [RefSeq, PubMed]; UbcM2 may play potential roles in the development of mouse diverse tissues and organs, particularly in the development of brain and skeleton., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.367", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.367", "type": "external" }, { "id": "6.3.2.n3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.n3", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "6.2.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.64", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004842 ubiquitin-protein transferase activity;GO:0042296 ISG15 transferase activity;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0010629 negative regulation of gene expression;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0016567 protein ubiquitination;GO:0000209 protein polyubiquitination;GO:0070936 protein K48-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P52482-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D1C1-1", "uniprot_id": [ { "id": "UBE2C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D1C1", "type": "external" } ], "mass": 19606.0, "length": 179, "protein_name": "Ubiquitin-conjugating enzyme E2 C", "gene_name": "Ube2c", "organism": "Mouse", "refseq_name": "ubiquitin-conjugating enzyme E2 C", "refseq_ac": [ { "id": "NP_081061", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081061", "type": "external" } ], "gene_names_uniprotkb": "Ube2c; Ubch10", "gene_names_refseq": "1110015A16Rik; D2Ertd695e; Ube2c", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 C; (E3-independent) E2 ubiquitin-conjugating enzyme C; 2.3.2.23; 2.3.2.24; E2 ubiquitin-conjugating enzyme C; UbcH10; Ubiquitin carrier protein C; Ubiquitin-protein ligase C", "protein_names_refseq": "(E3-independent) E2 ubiquitin-conjugating enzyme C; E2 ubiquitin-conjugating enzyme C; ubcH10; ubiquitin carrier protein C; ubiquitin-conjugating enzyme E2 C; ubiquitin-protein ligase C", "tax_id": 10090, "disease": "", "pathway": " (mmu:68612); (R-MMU-141430); (R-MMU-174048); (R-MMU-174084); (R-MMU-174154); (R-MMU-174178); (R-MMU-174184); (R-MMU-176407); (R-MMU-176408); (R-MMU-176409); (R-MMU-176412); (R-MMU-179409); (R-MMU-2467813); (R-MMU-2559582); (R-MMU-68867); (R-MMU-69017); (R-MMU-8866652); (R-MMU-983168)", "pathway_count": 18, "publication_count": 5, "publication_id_list": "20065091;21750661;25153642;25376843;38637730", "class_list": "", "function": "Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results identify UbcH10 as a prominent protooncogene that causes whole chromosome instability and tumor formation over a wide gradient of overexpression levels, [RefSeq, PubMed]; UBE2C promotes the proliferation of acute myeloid leukemia cells through PI3K/AKT activation. Publication Status: Online-Only, [RefSeq, PubMed]; UbcH10 overexpression increases carcinogenesis and blocks ALLN susceptibility in colorectal cancer. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TUJ0", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.367", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.367", "type": "external" }, { "id": "6.2.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.64", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004842 ubiquitin-protein transferase activity;GO:0044389 ubiquitin-like protein ligase binding;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005680 anaphase-promoting complex;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0051301 cell division;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0010458 exit from mitosis;GO:0031145 anaphase-promoting complex-dependent catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9D1C1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52623-1", "uniprot_id": [ { "id": "UCK1_MOUSE", "url": "https://www.uniprot.org/uniprot/P52623", "type": "external" } ], "mass": 31068.0, "length": 277, "protein_name": "Uridine-cytidine kinase 1", "gene_name": "Uck1", "organism": "Mouse", "refseq_name": "uridine-cytidine kinase 1 isoform 3", "refseq_ac": [ { "id": "NP_035805", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035805", "type": "external" } ], "gene_names_uniprotkb": "Uck1; Umpk", "gene_names_refseq": "URK1; Uck1; Umpk", "protein_names_uniprotkb": "Uridine-cytidine kinase 1; 2.7.1.48; Cytidine monophosphokinase 1; UCK 1; Uridine monophosphokinase 1", "protein_names_refseq": "cytidine monophosphokinase 1; uridine monophosphate kinase; uridine monophosphokinase 1; uridine-cytidine kinase 1 isoform 3", "tax_id": 10090, "disease": "nerve compression syndrome (Disease Ontology:DOID:573)", "pathway": " (mmu:22245); (R-MMU-73614)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21750661;8951040", "class_list": "", "function": "Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate (PubMed:8951040). Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.48", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004849 uridine kinase activity;GO:0043771 cytidine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0044206 UMP salvage;GO:0044211 CTP salvage", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P52623-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZU9-1", "uniprot_id": [ { "id": "UB2L6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QZU9", "type": "external" } ], "mass": 17841.0, "length": 153, "protein_name": "Ubiquitin/ISG15-conjugating enzyme E2 L6", "gene_name": "Ube2l6", "organism": "Mouse", "refseq_name": "ubiquitin/ISG15-conjugating enzyme E2 L6", "refseq_ac": [ { "id": "NP_064333", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064333", "type": "external" } ], "gene_names_uniprotkb": "Ube2l6; Ubce8", "gene_names_refseq": "2810489I21Rik; RIG-B; UBCH8; Ubce8; Ubcm8; Ube2l6", "protein_names_uniprotkb": "Ubiquitin/ISG15-conjugating enzyme E2 L6; 2.3.2.23; E2 ubiquitin-conjugating enzyme L6; UbcM8; Ubiquitin carrier protein L6; Ubiquitin-protein ligase L6", "protein_names_refseq": "E2 ubiquitin conjugating enzyme; E2 ubiquitin-conjugating enzyme L6; ubiquitin carrier protein L6; ubiquitin-conjugating enzyme 8; ubiquitin-protein ligase L6; ubiquitin/ISG15-conjugating enzyme E2 L6", "tax_id": 10090, "disease": "", "pathway": " (mmu:56791); (R-MMU-1169408); (R-MMU-5656169); (R-MMU-983168); (R-MMU-9833482); (R-MMU-9909505)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "15485925;21750661;23557705;37820603;38437929", "class_list": "", "function": "Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3., [UniProtKB, UniProtKB]; P53 accelerates endothelial cell senescence in diabetic retinopathy by enhancing FoxO3a ubiquitylation and degradation via UBE2L6., [RefSeq, PubMed]; Ubc8 is a major ISG15-conjugating enzyme responsible for protein ISGylation upon interferon stimulation, [RefSeq, PubMed]; Ube2L6 Promotes M1 Macrophage Polarization in High-Fat Diet-Fed Obese Mice via ISGylation of STAT1 to Trigger STAT1 Activation., [RefSeq, PubMed]; We have identified a loss-of-function mutation in Ube2l6 that contributes to the chromosome 2 obesity quantitative trait locus., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U8R0;Q922F1;Q9CQN0", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "6.3.2.n3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.n3", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "6.2.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.64", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.7.7.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.-", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0019787 ubiquitin-like protein transferase activity;GO:0043130 ubiquitin binding;GO:0042296 ISG15 transferase activity;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0045087 innate immune response;GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0019941 modification-dependent protein catabolic process;GO:0032020 ISG15-protein conjugation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9QZU9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJZ4-1", "uniprot_id": [ { "id": "UB2J1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JJZ4", "type": "external" } ], "mass": 34990.0, "length": 318, "protein_name": "Ubiquitin-conjugating enzyme E2 J1", "gene_name": "Ube2j1", "organism": "Mouse", "refseq_name": "ubiquitin-conjugating enzyme E2 J1 isoform 1", "refseq_ac": [ { "id": "NP_062532", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062532", "type": "external" } ], "gene_names_uniprotkb": "Ube2j1; Ncube1", "gene_names_refseq": "0710008M05Rik; 1110030I22Rik; NCUBE-1; Ncube1; Ncube; Ubc6p; Ube2j1", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 J1; 2.3.2.23; E2 ubiquitin-conjugating enzyme J1; NCUBE-1; Non-canonical ubiquitin-conjugating enzyme 1", "protein_names_refseq": "E2 ubiquitin-conjugating enzyme J1; non-canonical ubiquitin-conjugating enzyme 1; ubiquitin-conjugating enzyme E2 J1 isoform 1; ubiquitin-conjugating enzyme E2, J1", "tax_id": 10090, "disease": "", "pathway": " (mmu:56228); (R-MMU-983168)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;10708578;17208939;17242355;19144319;21183079;21750661;24020373;25320092;26495903;28011936;34428180;35831855", "class_list": "", "function": "Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD) and is essential for cells to recover from ER stress. Plays a role in MAPKAPK2-dependent translational control of TNF synthesis. Also acts as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1 through interaction with the E3 ubiquitin-protein ligase RNF26. Plays a role in male fecundity through the interaction with the E3 ubiquitin-protein ligase RNF133 (PubMed:35831855)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; UBE2J1 is required for spermiogenesis in mice, [RefSeq, PubMed]; Ube2j1 is phosphorylated in response to lipopolysaccharides in macrophages and contributes to MK2-dependent TNFalpha biosynthesis by an unknown mechanism. Erratum:[Biochem J. 2014 Jan 1;457(1):229], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9696, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9DC92", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "6.2.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.64", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0031625 ubiquitin protein ligase binding;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005789 endoplasmic reticulum membrane;GO:0000836 Hrd1p ubiquitin ligase complex", "go_biological_process": "GO:0007286 spermatid development;GO:0006487 protein N-linked glycosylation;GO:0000209 protein polyubiquitination;GO:0036503 ERAD pathway;GO:0032680 regulation of tumor necrosis factor production", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9JJZ4-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62377-1", "uniprot_id": [ { "id": "U2AFM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62377", "type": "external" } ], "mass": 55358.0, "length": 462, "protein_name": "U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2", "gene_name": "Zrsr2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Zrsr2; U2af1-rs2; U2af1l2; U2af1rs2", "gene_names_refseq": "", "protein_names_uniprotkb": "U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2; CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2; U2(RNU2) small nuclear RNA auxiliary factor 1-like 2; U2AF35-related protein; URP", "protein_names_refseq": "", "tax_id": 10090, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (mmu:22184); (R-MMU-72165)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21183079;21750661;7558001", "class_list": "", "function": "Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns. Selectively interacts with the 3'-splice site of U2- and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP-dependent manner and is required for assembly of the prespliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0030628 pre-mRNA 3'-splice site binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005681 spliceosomal complex;GO:0034693 U11/U12 snRNP;GO:0005689 U12-type spliceosomal complex;GO:0089701 U2AF complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0000245 spliceosomal complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q62377-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BJ37-1", "uniprot_id": [ { "id": "TYDP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BJ37", "type": "external" } ], "mass": 68689.0, "length": 609, "protein_name": "Tyrosyl-DNA phosphodiesterase 1", "gene_name": "Tdp1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Tdp1", "gene_names_refseq": "", "protein_names_uniprotkb": "Tyrosyl-DNA phosphodiesterase 1; 3.1.4.-; MLZ-501; Protein expressed in male leptotene and zygotene spermatocytes 501; Tyr-DNA phosphodiesterase 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "spinocerebellar ataxia with axonal neuropathy 1 (Disease Ontology:DOID:0090115)", "pathway": " (R-MMU-5693571)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17914460;17948061;20339383;21183079;21750661;28135057", "class_list": "", "function": "DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8VE39", "ec_number_list": [ { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0003690 double-stranded DNA binding;GO:0004527 exonuclease activity;GO:0003697 single-stranded DNA binding;GO:0017005 3'-tyrosyl-DNA phosphodiesterase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0006281 DNA repair;GO:0006302 double-strand break repair;GO:0000012 single strand break repair", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BJ37-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D384-1", "uniprot_id": [ { "id": "U1SBP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D384", "type": "external" } ], "mass": 29290.0, "length": 244, "protein_name": "U11/U12 small nuclear ribonucleoprotein 35 kDa protein", "gene_name": "Snrnp35", "organism": "Mouse", "refseq_name": "U11/U12 small nuclear ribonucleoprotein 35 kDa protein", "refseq_ac": [ { "id": "NP_083808", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083808", "type": "external" } ], "gene_names_uniprotkb": "Snrnp35; U1snrnpbp", "gene_names_refseq": "6330548G22Rik; Snrnp35", "protein_names_uniprotkb": "U11/U12 small nuclear ribonucleoprotein 35 kDa protein; U1 snRNP-binding protein homolog; U11/U12 snRNP 35 kDa protein", "protein_names_refseq": "U1 snRNP-binding protein homolog; U11/U12 small nuclear ribonucleoprotein 35 kDa protein; U11/U12 snRNP 35 kDa protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:76167); (R-MMU-72165)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;27557711;31599954", "class_list": "", "function": "Elevated U12-intron retention has been demonstrated in all examined tissues from spinal muscular atrophy mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CAC7", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0017069 snRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005681 spliceosomal complex;GO:0034693 U11/U12 snRNP;GO:0005689 U12-type spliceosomal complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D384-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PDD0-1", "uniprot_id": [ { "id": "UD2A2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PDD0", "type": "external" } ], "mass": 59967.0, "length": 528, "protein_name": "UDP-glucuronosyltransferase 2A2", "gene_name": "Ugt2a2", "organism": "Mouse", "refseq_name": "UDP-glucuronosyltransferase 2A2 precursor", "refseq_ac": [ { "id": "NP_001019319", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019319", "type": "external" } ], "gene_names_uniprotkb": "Ugt2a2", "gene_names_refseq": "Ugt2a2", "protein_names_uniprotkb": "UDP-glucuronosyltransferase 2A2; 2.4.1.17; UDPGT 2A2; UGT2A2", "protein_names_refseq": "UDP-glucuronosyltransferase 2A2 precursor; UDP-glucuronosyltransferase 2A2; UDPGT 2A2", "tax_id": 10090, "disease": "", "pathway": " (mmu:552899); (R-MMU-156588); (R-MMU-9749641)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;21750661", "class_list": "glycogene;glycosyltransferase", "function": "UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous estrogen hormone estradiol. Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption. Potential role in detoxification of toxic waste compounds in the amniotic fluid before birth, and air-born chemical after birth., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 18, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.17", "type": "external" }, { "id": "2.4.1.170", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.170", "type": "external" }, { "id": "2.4.1.185", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.185", "type": "external" } ], "go_molecular_function": "GO:0015020 glucuronosyltransferase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0008206 bile acid metabolic process;GO:0009608 response to symbiont", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6PDD0-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000011000.101.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61961-1", "uniprot_id": [ { "id": "UFM1_MOUSE", "url": "https://www.uniprot.org/uniprot/P61961", "type": "external" } ], "mass": 9118.0, "length": 85, "protein_name": "Ubiquitin-fold modifier 1", "gene_name": "Ufm1", "organism": "Mouse", "refseq_name": "ubiquitin-fold modifier 1", "refseq_ac": [ { "id": "NP_080711", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080711", "type": "external" } ], "gene_names_uniprotkb": "Ufm1", "gene_names_refseq": "1810045K17Rik; Gm10726; Ufm1", "protein_names_uniprotkb": "Ubiquitin-fold modifier 1", "protein_names_refseq": "ubiquitin-fold modifier 1", "tax_id": 10090, "disease": "autosomal recessive cerebellar ataxia (Disease Ontology:DOID:0050950); hypomyelinating leukodystrophy 14 (Disease Ontology:DOID:0080296)", "pathway": " (mmu:67890)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "16617122;18321862;21494687;21750661;26495903;31829413;33372156;35931931;36543799;37828378;37980507", "class_list": "", "function": "A novel ubiquitin fold modifier (Ufm1) not been previously associated with ER stress and not found to be induced under any condition was found to be upregulated in the hearts of MCP mice (transgenic mice that express MCP-1 specifically in the heart)., [RefSeq, PubMed]; Deficiency of Murine UFM1-Specific E3 Ligase Causes Microcephaly and Inflammation., [RefSeq, PubMed]; Loop between beta3 and alpha2 in addition to the C-terminal region of Ufm1 plays a role in binding to UfSP1, [RefSeq, PubMed]; Screening UFMylation-associated genes in heart tissues of Ufm1-transgenic mice. Publication Status: Online-Only, [RefSeq, PubMed]; The UFM1 system regulates ER-phagy through the ufmylation of CYB5R3. Publication Status: Online-Only, [RefSeq, PubMed]; UFMylation inhibits the proinflammatory capacity of interferon-gamma-activated macrophages., [RefSeq, PubMed]; Ubiquitin fold modifier 1 activates NF-kappaB pathway by down-regulating LZAP expression in the macrophage of diabetic mouse model., [RefSeq, PubMed]; Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer (PubMed:21494687). The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme UFC1, and the UFM1-ligase E3 enzyme UFL1 (By similarity). Ufmylation is involved in various processes, such as ribosome recycling, response to DNA damage, transcription or reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q14346;Q3TLT0;Q542A7;Q9CPX2;Q9NZF2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0007420 brain development;GO:0042308 negative regulation of protein import into nucleus;GO:0034976 response to endoplasmic reticulum stress;GO:0071569 protein ufmylation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P61961-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91YR1-1", "uniprot_id": [ { "id": "TWF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91YR1", "type": "external" } ], "mass": 40079.0, "length": 350, "protein_name": "Twinfilin-1", "gene_name": "Twf1", "organism": "Mouse", "refseq_name": "twinfilin-1 isoform 1", "refseq_ac": [ { "id": "NP_032997", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032997", "type": "external" } ], "gene_names_uniprotkb": "Twf1; Ptk9", "gene_names_refseq": "A6; Ptk9; Twf1; twinfilin", "protein_names_uniprotkb": "Twinfilin-1; Protein A6", "protein_names_refseq": "PTK9 protein tyrosine kinase 9; actin monomer-binding protein; protein A6; twinfilin, actin-binding protein, homolog 1; twinfilin-1 isoform 1; twinfilin-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:19230); (R-MMU-9013418)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "10669753;12207032;12807912;15282541;15592455;16511569;18034455;19131326;19768801;21750661;25428506;33226418;33558729;33639213;34428180;34678516;35168059;37507081;9249064", "class_list": "", "function": "Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Structural Insights into the Regulation of Actin Capping Protein by Twinfilin C-terminal Tail., [RefSeq, PubMed]; Structural conservation between its actin monomer-binding sites and the binding site of actin-depolymerizing factor (ADF)/cofilin, [RefSeq, PubMed]; Twinfilin bypasses assembly conditions and actin filament aging to drive barbed end depolymerization., [RefSeq, PubMed]; Twinfilin uncaps filament barbed ends to promote turnover of lamellipodial actin networks. Erratum:[Nat Cell Biol. 2021 Apr;23(4):437-438. doi: 10.1038/s41556-021-00651-8. PMID: 33654262], [RefSeq, PubMed]; Twinfilin-1 is an essential regulator of myogenic differentiation through the modulation of YAP in C2C12 myoblasts., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O09132;Q52L77;Q80X09", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0003785 actin monomer binding;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005884 actin filament;GO:0005911 cell-cell junction;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0010976 positive regulation of neuron projection development;GO:0051016 barbed-end actin filament capping;GO:0010613 positive regulation of cardiac muscle hypertrophy;GO:0030837 negative regulation of actin filament polymerization;GO:0010591 regulation of lamellipodium assembly", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q91YR1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62254-1", "uniprot_id": [ { "id": "UB2G1_MOUSE", "url": "https://www.uniprot.org/uniprot/P62254", "type": "external" } ], "mass": 19509.0, "length": 170, "protein_name": "Ubiquitin-conjugating enzyme E2 G1", "gene_name": "Ube2g1", "organism": "Mouse", "refseq_name": "ubiquitin-conjugating enzyme E2 G1", "refseq_ac": [ { "id": "NP_080261", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080261", "type": "external" } ], "gene_names_uniprotkb": "Ube2g1; Ube2g", "gene_names_refseq": "2700059C12Rik; D130023C12Rik; Ube2g1", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 G1; 2.3.2.23; E2 ubiquitin-conjugating enzyme G1; E217K; UBC7; Ubiquitin carrier protein G1; Ubiquitin-protein ligase G1", "protein_names_refseq": "E2 ubiquitin-conjugating enzyme G1; E217K; UBC7; ubiquitin carrier protein G1; ubiquitin-conjugating enzyme E2 G1; ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, C. elegans); ubiquitin-protein ligase G1", "tax_id": 10090, "disease": "azoospermia (Disease Ontology:DOID:14227); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (mmu:67128); (R-MMU-8866652); (R-MMU-983168)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4VAA6;Q99462", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "6.2.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.64", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0031625 ubiquitin protein ligase binding;GO:0004842 ubiquitin-protein transferase activity;GO:0061631 ubiquitin conjugating enzyme activity;GO:0016740 transferase activity", "go_cellular_component": "", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0000209 protein polyubiquitination;GO:0070936 protein K48-linked ubiquitination;GO:0030163 protein catabolic process;GO:0070534 protein K63-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P62254-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99KJ0-1", "uniprot_id": [ { "id": "UBX2A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99KJ0", "type": "external" } ], "mass": 29197.0, "length": 258, "protein_name": "UBX domain-containing protein 2A", "gene_name": "Ubxn2a", "organism": "Mouse", "refseq_name": "UBX domain-containing protein 2A", "refseq_ac": [ { "id": "NP_663416", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663416", "type": "external" } ], "gene_names_uniprotkb": "Ubxn2a; Ubxd4", "gene_names_refseq": "6330407P03Rik; Ubxd4; Ubxn2a", "protein_names_uniprotkb": "UBX domain-containing protein 2A; UBX domain-containing protein 4", "protein_names_refseq": "UBX domain containing 4; UBX domain-containing protein 2A; UBX domain-containing protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:217379)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;19474315;21750661;25428506;26265139;30107089;37037900", "class_list": "", "function": "Acts to repress the ubiquitination and subsequent endoplasmic reticulum-associated degradation of CHRNA3 by the STUB1-VCP-UBXN2A complex in cortical neurons (PubMed:19474315). Also acts to promote the translocation of CHRNA3 to the plasma membrane and subsequently increases plasma membrane acetylcholine-gated ion-channel activation (PubMed:19474315). Plays a role in the inhibition of STUB1-mediated TP53 degradation, via its interaction with HSPA9 which acts to inhibit TP53 binding to HSPA9 (By similarity). Positively mediates the ubiquitination and proteosomal degradation of RICTOR, may thereby act as a negative regulator of the mTORC2 pathway (By similarity)., [UniProtKB, PubMed, UniProtKB]; The existence of a multiprotein complex containing UBXN2A, CHIP, and mot-2 suggests a synergistic tumor suppressor activity of UBXN2A and CHIP in mot-2-enriched tumors., [RefSeq, PubMed]; UBXN2A suppresses the Rictor-mTORC2 signaling pathway, an established tumorigenic pathway in human colorectal cancer., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0033130 acetylcholine receptor binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0031468 nuclear membrane reassembly;GO:0000045 autophagosome assembly;GO:1990830 cellular response to leukemia inhibitory factor;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045732 positive regulation of protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q99KJ0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99KD5-1", "uniprot_id": [ { "id": "UN45A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99KD5", "type": "external" } ], "mass": 103447.0, "length": 944, "protein_name": "Protein unc-45 homolog A", "gene_name": "Unc45a", "organism": "Mouse", "refseq_name": "protein unc-45 homolog A", "refseq_ac": [ { "id": "NP_598713", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598713", "type": "external" } ], "gene_names_uniprotkb": "Unc45a; Smap1", "gene_names_refseq": "Unc45a", "protein_names_uniprotkb": "Protein unc-45 homolog A; SMAP-1; Stromal membrane-associated protein 1; Unc-45A", "protein_names_refseq": "SMAP-1; UNC-45A; protein unc-45 homolog A; smooth muscle cell associated protein-1; stromal membrane-associated protein 1; unc-45 homolog A", "tax_id": 10090, "disease": "", "pathway": " (mmu:101869)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "12356907;20173027;21750661;25428506;30084848;30779550;33372036;34206743;34428180;35820727;39627609;9209433", "class_list": "", "function": "May act as co-chaperone for HSP90 (Potential). Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell (By similarity). May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen., [UniProtKB, PubMed, PubMed]; May act as co-chaperone for HSP90. Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell. May be necessary for proper folding of myosin. Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen., [UniProtKB, UniProtKB]; The ATPase mechanism of myosin 15, the molecular motor mutated in DFNB3 human deafness., [RefSeq, PubMed]; UNC-45A Is Highly Expressed in the Proliferative Cells of the Mouse Genital Tract and in the Microtubule-Rich Areas of the Mouse Nervous System. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TKV6;Q8BFT3;Q8C157", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0051879 Hsp90 protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0030154 cell differentiation;GO:0007517 muscle organ development;GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q99KD5-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EPV8-1", "uniprot_id": [ { "id": "UBL5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EPV8", "type": "external" } ], "mass": 8547.0, "length": 73, "protein_name": "Ubiquitin-like protein 5", "gene_name": "Ubl5", "organism": "Mouse", "refseq_name": "ubiquitin-like protein 5 isoform 2", "refseq_ac": [ { "id": "NP_079677", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079677", "type": "external" } ], "gene_names_uniprotkb": "Ubl5", "gene_names_refseq": "1110030M22Rik; Ubl5a; Ubl5; beacon", "protein_names_uniprotkb": "Ubiquitin-like protein 5", "protein_names_refseq": "ubiquitin-like protein 5 isoform 2; ubiquitin-like protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:66177); (R-MMU-72163)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "12932856;17026961;21750661;34428180;37315790", "class_list": "", "function": "Findings report of the presence and distribution of ubiquitin-like 5 in the mouse hypothalamus and pituitary, [RefSeq, PubMed]; This report is the first to describe changes in the intracellular and subcellular localization of UBL5 in response to hypo-osmotic conditions., [RefSeq, PubMed]; Ubiquitin-like protein 5 is a novel player in the UPR-PERK arm and ER stress-induced cell death., [RefSeq, PubMed]; Ubiquitin-like protein that plays a role in cell proliferation and sister chromatid cohesion by associating with spliceosomal proteins. Participates thereby in pre-mRNA splicing by maintaining spliceosome integrity. Promotes the functional integrity of the Fanconi anemia DNA repair pathway by interacting with FANCI component and subsequently mediating the formation of FANCI homodimers. Also plays a protective role against ER stress-induced apoptosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031386 protein tag activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9EPV8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0CG50-1", "uniprot_id": [ { "id": "UBC_MOUSE", "url": "https://www.uniprot.org/uniprot/P0CG50", "type": "external" } ], "mass": 82550.0, "length": 734, "protein_name": "Polyubiquitin-C", "gene_name": "Ubc", "organism": "Mouse", "refseq_name": "polyubiquitin-C", "refseq_ac": [ { "id": "NP_062613", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062613", "type": "external" } ], "gene_names_uniprotkb": "Ubc", "gene_names_refseq": "2700054O04Rik; Rps27a; TI-225; Uba52; Ubb; Ubc", "protein_names_uniprotkb": "Polyubiquitin-C", "protein_names_refseq": "polyubiquitin C; polyubiquitin-C", "tax_id": 10090, "disease": "", "pathway": " (mmu:22190); (R-MMU-110312); (R-MMU-110314); (R-MMU-110320); (R-MMU-1169091); (R-MMU-1234176); (R-MMU-1253288); (R-MMU-1295596); (R-MMU-1358803); (R-MMU-168638); (R-MMU-174048); (R-MMU-174084); (R-MMU-174113); (R-MMU-174154); (R-MMU-174178); (R-MMU-174184); (R-MMU-179409); (R-MMU-182971); (R-MMU-187577); (R-MMU-195253); (R-MMU-201681); (R-MMU-202424); (R-MMU-205043); (R-MMU-209543); (R-MMU-209560); (R-MMU-2122948); (R-MMU-2173788); (R-MMU-2173791); (R-MMU-2173795); (R-MMU-2173796); (R-MMU-2467813); (R-MMU-2559580); (R-MMU-2559582); (R-MMU-2559585); (R-MMU-2565942); (R-MMU-2672351); (R-MMU-2871837); (R-MMU-3134975); (R-MMU-349425); (R-MMU-3769402); (R-MMU-382556); (R-MMU-445989); (R-MMU-450302); (R-MMU-450321); (R-MMU-450408); (R-MMU-4608870); (R-MMU-4641257); (R-MMU-4641258); (R-MMU-4641263); (R-MMU-5205685); (R-MMU-532668); (R-MMU-5357905); (R-MMU-5357956); (R-MMU-5358346); (R-MMU-5607761); (R-MMU-5607764); (R-MMU-5610780); (R-MMU-5610785); (R-MMU-5632684); (R-MMU-5654726); (R-MMU-5654727); (R-MMU-5654732); (R-MMU-5654733); (R-MMU-5655862); (R-MMU-5656121); (R-MMU-5656169); (R-MMU-5658442); (R-MMU-5668541); (R-MMU-5675221); (R-MMU-5675482); (R-MMU-5676590); (R-MMU-5684264); (R-MMU-5685942); (R-MMU-5687128); (R-MMU-5689603); (R-MMU-5689877); (R-MMU-5689880); (R-MMU-5689896); (R-MMU-5689901); (R-MMU-5693537); (R-MMU-5693565); (R-MMU-5693607); (R-MMU-5696394); (R-MMU-5696395); (R-MMU-5696397); (R-MMU-5696400); (R-MMU-6781823); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-6783310); (R-MMU-6804756); (R-MMU-6804757); (R-MMU-6804760); (R-MMU-6807004); (R-MMU-68867); (R-MMU-68949); (R-MMU-69017); (R-MMU-69231); (R-MMU-69481); (R-MMU-69541); (R-MMU-69601); (R-MMU-75815); (R-MMU-8849469); (R-MMU-8852276); (R-MMU-8854050); (R-MMU-8856825); (R-MMU-8856828); (R-MMU-8863795); (R-MMU-8866427); (R-MMU-8866652); (R-MMU-8866654); (R-MMU-8939236); (R-MMU-8939902); (R-MMU-8941858); (R-MMU-8948747); (R-MMU-8948751); (R-MMU-8951664); (R-MMU-901032); (R-MMU-9010553); (R-MMU-9013507); (R-MMU-9020702); (R-MMU-9033241); (R-MMU-909733); (R-MMU-912631); (R-MMU-917729); (R-MMU-917937); (R-MMU-936440); (R-MMU-936964); (R-MMU-937039); (R-MMU-937041); (R-MMU-937042); (R-MMU-937072); (R-MMU-9645460); (R-MMU-9646399); (R-MMU-9648002); (R-MMU-9664873); (R-MMU-9705462); (R-MMU-9706369); (R-MMU-9708530); (R-MMU-975144); (R-MMU-975163); (R-MMU-9755511); (R-MMU-9758274); (R-MMU-9762114); (R-MMU-9766229); (R-MMU-9770562); (R-MMU-9824878); (R-MMU-983168); (R-MMU-9861718); (R-MMU-9929356); (R-MMU-9929491); (R-MMU-9931269); (R-MMU-9931295); (R-MMU-9932298); (R-MMU-9954709); (R-MMU-9954716); (R-MMU-9958810); (R-MMU-9958825)", "pathway_count": 158, "publication_count": 8, "publication_id_list": "12107596;19754430;21750661;25428506;28011936;33300544;34887587;8631027", "class_list": "", "function": "Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. During ubiquitination, the acceptor ubiquitin is positioned in the active site via direct interaction with the E2 ubiquitin-conjugating enzymes such as UBE2R2 (By similarity). As a monoubiquitin, its C-terminal glycine is recognized as a C-degron by Cul2-RING (CRL2) E3 ubiquitin-protein ligase complexes (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QKI0;P02248;P02249;P02250;P62991;Q29120;Q62317;Q64223;Q8VCH1;Q91887;Q91888;Q9CXY4;Q9CZM0;Q9D1R5;Q9D8D9;Q9ET23;Q9ET24;Q9Z0H9", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0031386 protein tag activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol;GO:0043209 myelin sheath", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0019941 modification-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P0CG50-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91W36-1", "uniprot_id": [ { "id": "UBP3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91W36", "type": "external" } ], "mass": 58868.0, "length": 520, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 3", "gene_name": "Usp3", "organism": "Mouse", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 3 isoform 1", "refseq_ac": [ { "id": "NP_659186", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659186", "type": "external" } ], "gene_names_uniprotkb": "Usp3", "gene_names_refseq": "Usp3", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 3; 3.4.19.12; Deubiquitinating enzyme 3; Ubiquitin thioesterase 3; Ubiquitin-specific-processing protease 3", "protein_names_refseq": "deubiquitinating enzyme 3; ubiquitin carboxyl-terminal hydrolase 3 isoform 1; ubiquitin carboxyl-terminal hydrolase 3; ubiquitin specific protease 3; ubiquitin thioesterase 3; ubiquitin thiolesterase 3; ubiquitin-specific-processing protease 3", "tax_id": 10090, "disease": "glioblastoma (Disease Ontology:DOID:3068)", "pathway": " (mmu:235441); (R-MMU-5689880)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;25113974;37170124", "class_list": "", "function": "CRISPR/Cas9-based genome-wide screening of the deubiquitinase subfamily identifies USP3 as a protein stabilizer of REST blocking neuronal differentiation and promotes neuroblastoma tumorigenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Deubiquitinase that plays a role in several cellular processes including transcriptional regulation, cell cycle progression or innate immunity. In response to DNA damage, deubiquitinates monoubiquitinated target proteins such as histone H2A and H2AX and thereby counteracts RNF168- and RNF8-mediated ubiquitination. In turn, participates in the recruitment of DNA damage repair factors to DNA break sites (PubMed:25113974). Required for proper progression through S phase and subsequent mitotic entry. Acts as a positive regulator of TP53 by deubiquitinating and stabilizing it to promote normal cell proliferation and transformation. Participates in establishing tolerance innate immune memory through non-transcriptional feedback. Mechanistically, negatively regulates TLR-induced NF-kappa-B signaling by targeting and removing the 'Lys-63'-linked polyubiquitin chains on MYD88. Negatively regulates the activation of type I interferon signaling by mediating 'Lys-63'-linked polyubiquitin chains on RIGI and IFIH1. Also deubiquitinates ASC/PYCARD, the central adapter mediating the assembly and activation of most inflammasomes, and thereby promotes inflammasome activation., [UniProtKB, UniProtKB, PubMed]; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes., [UniProtKB, UniProtKB, UniProtKB]; The protein encoded by this gene is a chromatin-associated histone 2A and 2B deubiquitinating enzyme that negatively regulates the DNA damage response. Mice deficient for this enzyme have reduced hematopoietic stem cell reserves, demonstrating a requirement in hematopoietic stem cell homeostasis. In addition, knock down of protein levels results in spontaneous tumor development and shortened lifespan, consistent with a function in preserving chromosomal integrity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]., [RefSeq]; USP3 deletion increased the levels of histone ubiquitination in adult tissues, reduced the hematopoietic stem cell reserves over time, and shortened animal life span., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0042393 histone binding;GO:0004843 cysteine-type deubiquitinase activity;GO:1990841 promoter-specific chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0036464 cytoplasmic ribonucleoprotein granule;GO:0000785 chromatin", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006281 DNA repair;GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0140861 DNA repair-dependent chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q91W36-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q9U0-1", "uniprot_id": [ { "id": "U17PB_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q9U0", "type": "external" } ], "mass": 52114.0, "length": 468, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 17-like protein B", "gene_name": "Usp17lb", "organism": "Mouse", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 17-like protein B isoform 1", "refseq_ac": [ { "id": "NP_958811", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_958811", "type": "external" } ], "gene_names_uniprotkb": "Usp17lb; Dub1a", "gene_names_refseq": "DUB-1A; Dub1a; USP17-B; Usp17lb", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 17-like protein B; 3.4.19.12; Deubiquitinating enzyme 1A; USP17-B", "protein_names_refseq": "deubiquitinating enzyme 1a; ubiquitin carboxyl-terminal hydrolase 17-like protein B isoform 1; ubiquitin carboxyl-terminal hydrolase 17-like protein B", "tax_id": 10090, "disease": "congenital heart disease (Disease Ontology:DOID:1682); primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (mmu:381944); (R-MMU-5689880)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "14583620;25428506", "class_list": "", "function": "DUB-1A has functional deubiquitinating activity and the 5'-flanking sequence of Dub-1A has a functional enhancer domain.Dub-1A is expressed in B- and T-lymphocytes, brain, heart, liver, lung, kidney, ovary, and spleen, [RefSeq, PubMed]; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7ZN74;E9QMF1;Q6X3X0", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.4.26.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.26.1", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0004843 cysteine-type deubiquitinase activity;GO:0005540 hyaluronic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0031647 regulation of protein stability;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E9Q9U0-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8JZU2-1", "uniprot_id": [ { "id": "TXTP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8JZU2", "type": "external" } ], "mass": 33931.0, "length": 311, "protein_name": "Tricarboxylate transport protein, mitochondrial", "gene_name": "Slc25a1", "organism": "Mouse", "refseq_name": "tricarboxylate transport protein, mitochondrial", "refseq_ac": [ { "id": "NP_694790", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694790", "type": "external" } ], "gene_names_uniprotkb": "Slc25a1", "gene_names_refseq": "1300019P08Rik; 2610100G11Rik; Ctp; Dgsj; Slc20a3; Slc25a1", "protein_names_uniprotkb": "Tricarboxylate transport protein, mitochondrial; CTP; Citrate transport protein; Solute carrier family 25 member 1; Tricarboxylate carrier protein", "protein_names_refseq": "DiGeorge syndrome gene j; citrate transport protein; solute carrier family 25 member 1; tricarboxylate carrier protein; tricarboxylate transport protein, mitochondrial", "tax_id": 10090, "disease": "2-hydroxyglutaric aciduria (Disease Ontology:DOID:0050573); chromosome 22q11.2 deletion syndrome, distal (Disease Ontology:DOID:0060413); combined D-2- and L-2-hydroxyglutaric aciduria (Disease Ontology:DOID:0111619); DiGeorge syndrome (Disease Ontology:DOID:11198); congenital myasthenic syndrome (Disease Ontology:DOID:3635); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (mmu:13358); (R-MMU-428643)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "12865426;18775783;21750661;29187734;33300544;34428180;37453647;37507081", "class_list": "", "function": "Mitochondrial electroneutral antiporter that exports citrate from the mitochondria into the cytosol in exchange for malate. Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis-aconitate and to a lesser extent trans-aconitate, maleate and succinate. Substrate exchange across the membrane occurs consecutively with one substrate being transported first, then dissociating from the substrate binding site before the second substrate binds for transport in the opposite direction. In the cytoplasm, citrate plays important roles in fatty acid and sterol synthesis, regulation of glycolysis, protein acetylation, and other physiopathological processes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TDH6", "ec_number_list": [], "go_molecular_function": "GO:0015297 antiporter activity;GO:0015142 tricarboxylic acid transmembrane transporter activity;GO:0071913 citrate secondary active transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0006843 mitochondrial citrate transmembrane transport;GO:0110076 negative regulation of ferroptosis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8JZU2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P83877-1", "uniprot_id": [ { "id": "TXN4A_MOUSE", "url": "https://www.uniprot.org/uniprot/P83877", "type": "external" } ], "mass": 16786.0, "length": 142, "protein_name": "Thioredoxin-like protein 4A", "gene_name": "Txnl4a", "organism": "Mouse", "refseq_name": "thioredoxin-like protein 4A isoform a", "refseq_ac": [ { "id": "NP_079575", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079575", "type": "external" } ], "gene_names_uniprotkb": "Txnl4a; Dim1; Txnl4", "gene_names_refseq": "D18Wsu98e; Dim1; Txnl4a; Txnl4; U5-15kDa; U5-15kD", "protein_names_uniprotkb": "Thioredoxin-like protein 4A; DIM1 protein homolog; Spliceosomal U5 snRNP-specific 15 kDa protein; Thioredoxin-like U5 snRNP protein U5-15kD", "protein_names_refseq": "DIM1 protein homolog; spliceosomal U5 snRNP-specific 15 kDa protein; thioredoxin-like 4; thioredoxin-like U5 snRNP protein U5-15kD; thioredoxin-like protein 4A isoform a; thioredoxin-like protein 4A", "tax_id": 10090, "disease": "Ogden syndrome (Disease Ontology:DOID:0050781); Burn-McKeown syndrome (Disease Ontology:DOID:0080695); cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:27366); (R-MMU-72163); (R-MMU-72165)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "21750661;31219806;34428180", "class_list": "", "function": "Plays a role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes that are involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O14834;Q3TLI3", "ec_number_list": [], "go_molecular_function": "GO:0004596 protein-N-terminal amino-acid acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005813 centrosome", "go_biological_process": "GO:0051301 cell division;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P83877-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D883-1", "uniprot_id": [ { "id": "U2AF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D883", "type": "external" } ], "mass": 27815.0, "length": 239, "protein_name": "Splicing factor U2AF 35 kDa subunit", "gene_name": "U2af1", "organism": "Mouse", "refseq_name": "splicing factor U2AF 35 kDa subunit isoform 2", "refseq_ac": [ { "id": "NP_001157241", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157241", "type": "external" } ], "gene_names_uniprotkb": "U2af1", "gene_names_refseq": "2010107D16Rik; U2af1", "protein_names_uniprotkb": "Splicing factor U2AF 35 kDa subunit; U2 auxiliary factor 35 kDa subunit; U2 snRNP auxiliary factor small subunit", "protein_names_refseq": "U2 auxiliary factor 35 kDa subunit; U2 snRNP auxiliary factor small subunit; splicing factor U2AF 35 kDa subunit isoform 2; splicing factor U2AF 35 kDa subunit", "tax_id": 10090, "disease": "", "pathway": " (mmu:108121); (R-MMU-159236); (R-MMU-72163); (R-MMU-72187); (R-MMU-9770562)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;18758164;21750661;29187734;33300544;34428180;34469727;34546980;36922625;37453647;37591942", "class_list": "", "function": "Impact of U2AF1 mutations on circular RNA expression in myelodysplastic neoplasms., [RefSeq, PubMed]; Mutant U2AF1-induced alternative splicing of H2afy (macroH2A1) regulates B-lymphopoiesis in mice., [RefSeq, PubMed]; Myelodysplastic neoplasm-associated U2AF1 mutations induce host defense defects by compromising neutrophil chemotaxis., [RefSeq, PubMed]; Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron (By similarity)., [UniProtKB]; U2af1 is a haplo-essential gene required for hematopoietic cancer cell survival in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q564E4;Q99LX2;Q9CZ98", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0030628 pre-mRNA 3'-splice site binding;GO:0050733 RS domain binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0071013 catalytic step 2 spliceosome;GO:0089701 U2AF complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9D883-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C8T8-1", "uniprot_id": [ { "id": "TSR2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C8T8", "type": "external" } ], "mass": 20891.0, "length": 191, "protein_name": "Pre-rRNA-processing protein TSR2 homolog", "gene_name": "Tsr2", "organism": "Mouse", "refseq_name": "pre-rRNA-processing protein TSR2 homolog isoform 2", "refseq_ac": [ { "id": "NP_780355", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780355", "type": "external" } ], "gene_names_uniprotkb": "Tsr2", "gene_names_refseq": "2310007F12Rik; Tsr2", "protein_names_uniprotkb": "Pre-rRNA-processing protein TSR2 homolog", "protein_names_refseq": "TSR2, 20S rRNA accumulation, homolog; pre-rRNA-processing protein TSR2 homolog isoform 2; pre-rRNA-processing protein TSR2 homolog", "tax_id": 10090, "disease": "Diamond-Blackfan anemia 14 with mandibulofacial dysostosis (Disease Ontology:DOID:0111897)", "pathway": " (mmu:69499)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May be involved in 20S pre-rRNA processing., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ALP6;Q8R3M9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8C8T8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G5E8G2-1", "uniprot_id": [ { "id": "U17PD_MOUSE", "url": "https://www.uniprot.org/uniprot/G5E8G2", "type": "external" } ], "mass": 61450.0, "length": 545, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 17-like protein D", "gene_name": "Usp17ld", "organism": "Mouse", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 17-like protein D", "refseq_ac": [ { "id": "NP_001001559", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001559", "type": "external" } ], "gene_names_uniprotkb": "Usp17ld; Dub2a", "gene_names_refseq": "Dub2a; Dub4; Usp17ld", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 17-like protein D; 3.4.19.12; Deubiquitinating enzyme 2A", "protein_names_refseq": "deubiquitinating enzyme 2a; ubiquitin carboxyl-terminal hydrolase 17-like protein D", "tax_id": 10090, "disease": "congenital heart disease (Disease Ontology:DOID:1682); primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (mmu:384701); (R-MMU-5689880)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "11468161;21115691", "class_list": "", "function": "Data show that DUBA short interference RNA augmented the TLR9-dependent type I IFN response., [RefSeq, PubMed]; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q923V2;Q923V3", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.4.26.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.26.1", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0004843 cysteine-type deubiquitinase activity;GO:0005540 hyaluronic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0031647 regulation of protein stability;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "G5E8G2-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P5G6-1", "uniprot_id": [ { "id": "UBXN7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P5G6", "type": "external" } ], "mass": 52164.0, "length": 467, "protein_name": "UBX domain-containing protein 7", "gene_name": "Ubxn7", "organism": "Mouse", "refseq_name": "UBX domain-containing protein 7 isoform 2", "refseq_ac": [ { "id": "NP_001392826", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001392826", "type": "external" } ], "gene_names_uniprotkb": "Ubxn7; Kiaa0794; Ubxd7", "gene_names_refseq": "A630090P18; Ubxd7; Ubxn7; mKIAA0794", "protein_names_uniprotkb": "UBX domain-containing protein 7", "protein_names_refseq": "UBX domain containing 7; UBX domain-containing protein 7 isoform 2; UBX domain-containing protein 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:224111); (R-MMU-8951664); (R-MMU-9755511)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "15345747;17242355;21183079;21750661;28135057;31219806;40684658", "class_list": "", "function": "Ubiquitin-binding adapter that links a subset of NEDD8-associated cullin ring ligases (CRLs) to the segregase VCP/p97, to regulate turnover of their ubiquitination substrates (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZQ44", "ec_number_list": [], "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0043130 ubiquitin binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex;GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q6P5G6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KUS2-1", "uniprot_id": [ { "id": "UN13A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q4KUS2", "type": "external" } ], "mass": 193782.0, "length": 1712, "protein_name": "Protein unc-13 homolog A", "gene_name": "Unc13a", "organism": "Mouse", "refseq_name": "protein unc-13 homolog A", "refseq_ac": [ { "id": "NP_001025044", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025044", "type": "external" } ], "gene_names_uniprotkb": "Unc13a", "gene_names_refseq": "2410078G03Rik; Munc13-1; Unc13a", "protein_names_uniprotkb": "Protein unc-13 homolog A; Munc13-1", "protein_names_refseq": "protein unc-13 homolog A", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); epilepsy (Disease Ontology:DOID:1826); amyotrophic lateral sclerosis (Disease Ontology:DOID:332)", "pathway": " (mmu:382018)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;10440375;12070347;15988013;16452087;16644700;16697276;17267576;17639022;19996097;21750661;22872234;23229896;28192369;33300544;39627609;40021952", "class_list": "", "function": "Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. Facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (PubMed:23229896). Also involved in secretory granule priming in insulin secretion. Plays a role in dendrite formation by melanocytes (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 3, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "E9QKH9;Q3UHG2", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005543 phospholipid binding;GO:0008270 zinc ion binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0044305 calyx of Held;GO:0005798 Golgi-associated vesicle;GO:0005886 plasma membrane;GO:0030424 axon", "go_biological_process": "GO:1903861 positive regulation of dendrite extension;GO:0060384 innervation;GO:0048172 regulation of short-term neuronal synaptic plasticity;GO:0007528 neuromuscular junction development;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q4KUS2-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P902-1", "uniprot_id": [ { "id": "TXND2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P902", "type": "external" } ], "mass": 57767.0, "length": 515, "protein_name": "Thioredoxin domain-containing protein 2", "gene_name": "Txndc2", "organism": "Mouse", "refseq_name": "thioredoxin domain-containing protein 2 isoform 1", "refseq_ac": [ { "id": "NP_001139474", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139474", "type": "external" } ], "gene_names_uniprotkb": "Txndc2; Sptrx1; Sptrx; Trx4", "gene_names_refseq": "Sptrx-1; Sptrx1; Trx4; Txndc2", "protein_names_uniprotkb": "Thioredoxin domain-containing protein 2; Spermatid-specific thioredoxin-1; Sptrx-1; Thioredoxin-4", "protein_names_refseq": "spermatid-specific thioredoxin 1; thioredoxin domain-containing protein 2 isoform 1; thioredoxin domain-containing protein 2; thioredoxin-4", "tax_id": 10090, "disease": "", "pathway": " (mmu:213272)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12149401;12390887;15781233;21750661;23707457", "class_list": "", "function": "Probably plays a regulatory role in sperm development. May participate in regulation of fibrous sheath (FS) assembly by supporting the formation of disulfide bonds during sperm tail morphogenesis. May also be required to rectify incorrect disulfide pairing and generate suitable pairs between the FS constituents. Can reduce disulfide bonds in vitro in the presence of NADP and thioredoxin reductase., [UniProtKB]; Txndc2 and Txndc3 are critically important in protecting spermatozoa against the increases in oxidative stress associated with paternal age., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CJD1", "ec_number_list": [], "go_molecular_function": "GO:0004791 thioredoxin-disulfide reductase (NADPH) activity;GO:0003756 protein disulfide isomerase activity", "go_cellular_component": "GO:0001520 outer dense fiber;GO:0005737 cytoplasm;GO:0036126 sperm flagellum", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0030317 flagellated sperm motility;GO:0034614 cellular response to reactive oxygen species", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6P902-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CR09-1", "uniprot_id": [ { "id": "UFC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CR09", "type": "external" } ], "mass": 19481.0, "length": 167, "protein_name": "Ubiquitin-fold modifier-conjugating enzyme 1", "gene_name": "Ufc1", "organism": "Mouse", "refseq_name": "ubiquitin-fold modifier-conjugating enzyme 1 isoform a", "refseq_ac": [ { "id": "NP_079664", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079664", "type": "external" } ], "gene_names_uniprotkb": "Ufc1", "gene_names_refseq": "1110021H02Rik; ESTM29; Ufc1", "protein_names_uniprotkb": "Ubiquitin-fold modifier-conjugating enzyme 1; Ufm1-conjugating enzyme 1", "protein_names_refseq": "Ufm1-conjugating enzyme 1; ubiquitin-fold modifier-conjugating enzyme 1 isoform a", "tax_id": 10090, "disease": "neurodevelopmental disorder with spasticity and poor growth (Disease Ontology:DOID:0070421)", "pathway": " (mmu:66155)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;24714921;33372156", "class_list": "", "function": "E2-like enzyme which specifically catalyzes the second step in ufmylation (By similarity). Accepts the ubiquitin-like modifier UFM1 from the E1 enzyme UBA5 and forms an intermediate with UFM1 via a thioester linkage (By similarity). Ufmylation is involved in various processes, such as ribosome recycling, response to DNA damage, interferon response or reticulophagy (also called ER-phagy) (PubMed:33372156)., [UniProtKB, UniProtKB, PubMed]; E2-like enzyme which specifically catalyzes the second step in ufmylation. Accepts the ubiquitin-like modifier UFM1 from the E1 enzyme UBA5 and forms an intermediate with UFM1 via a thioester linkage. Ufmylation is involved in various processes, such as ribosome recycling, response to DNA damage, interferon response or reticulophagy (also called ER-phagy)., [UniProtKB, UniProtKB]; Results suggest that Ufm1 is upregulated in diabetic mouse RPMs and in Raw264.7 cells in response to ER stress and that Ufm1 protects macrophages against apoptosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0071568 UFM1 transferase activity;GO:0061657 UFM1 conjugating enzyme activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007420 brain development;GO:0034976 response to endoplasmic reticulum stress;GO:0071569 protein ufmylation;GO:0061709 reticulophagy;GO:1990592 protein K69-linked ufmylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CR09-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08934-1", "uniprot_id": [ { "id": "UNC4_MOUSE", "url": "https://www.uniprot.org/uniprot/O08934", "type": "external" } ], "mass": 53936.0, "length": 530, "protein_name": "Homeobox protein unc-4 homolog", "gene_name": "Uncx", "organism": "Mouse", "refseq_name": "homeobox protein unc-4 homolog", "refseq_ac": [ { "id": "NP_038730", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038730", "type": "external" } ], "gene_names_uniprotkb": "Uncx; Uncx4.1", "gene_names_refseq": "Chx4; Uncx4.1; Uncx", "protein_names_uniprotkb": "Homeobox protein unc-4 homolog; Homeobox protein Uncx4.1", "protein_names_refseq": "Unc4.1 homeobox; homeobox protein Uncx4.1; homeobox protein unc-4 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:22255)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10330372;10545229;10804168;10804169;11747084;11973278;16461927;16728472;17477400;17531978;21750661;8855241;9286595", "class_list": "", "function": "Transcription factor involved in somitogenesis and neurogenesis. Required for the maintenance and differentiation of particular elements of the axial skeleton. May act upstream of PAX9. Plays a role in controlling the development of connections of hypothalamic neurons to pituitary elements, allowing central neurons to reach the peripheral blood circulation and to deliver hormones for control of peripheral functions., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P70457;Q78DU3", "ec_number_list": [], "go_molecular_function": "GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0021516 dorsal spinal cord development;GO:0006351 DNA-templated transcription;GO:0045595 regulation of cell differentiation;GO:0010468 regulation of gene expression;GO:0001502 cartilage condensation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "O08934-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54863-1", "uniprot_id": [ { "id": "TSSK2_MOUSE", "url": "https://www.uniprot.org/uniprot/O54863", "type": "external" } ], "mass": 41022.0, "length": 358, "protein_name": "Testis-specific serine/threonine-protein kinase 2", "gene_name": "Tssk2", "organism": "Mouse", "refseq_name": "testis-specific serine/threonine-protein kinase 2", "refseq_ac": [ { "id": "NP_033462", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033462", "type": "external" } ], "gene_names_uniprotkb": "Tssk2; Stk22b", "gene_names_refseq": "DGS-G; SPOGA2; Stk22b; Tsk2; Tssk2", "protein_names_uniprotkb": "Testis-specific serine/threonine-protein kinase 2; 2.7.11.1; Serine/threonine-protein kinase 22B; TSK-2; TSK2; TSSK-2; Testis-specific kinase 2", "protein_names_refseq": "TSK-2; TSSK-2; serine/threonine kinase 22B (spermiogenesis associated); serine/threonine-protein kinase 22B; testis specific serine/ threonine kinase 2; testis-specific kinase 2; testis-specific serine/threonine-protein kinase 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:22115)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10781952;18367677;18495105;18533145;20053632;20729278;22855445;23599433;9412477;9651519", "class_list": "", "function": "HSP90 function abolished the catalytic activities of TSSK4 and -6 but did not significantly alter the specific activities of TSSK1 and -2. Inhibition of HSP90 resulted in increased TSSK ubiquitination and proteasomal degradation, [RefSeq, PubMed]; Results reveal TSSK1- and TSSK2-dependent functions of a transformed chromatoid body in post-meiotic cytodifferentiation of spermatids., [RefSeq, PubMed]; TSSK1 and TSKS persist in sperm, define a critical role of TSKS' N-terminus in enzyme interaction, identify Ser 281 as a TSKS phosphorylation site and indicate an indispensable role for TSSK 1 and 2 in spermiogenesis., [RefSeq, PubMed]; Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates 'Ser-281' of TSKS and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; The expression patterns of Tsk2 is documented throughout spermiogenesis showing a late association of Tsk2 with tail-like structures in the lumen of the seminiferous tubule., [RefSeq, PubMed]; Tssk1 and Tssk2 play an important role in the regulation of sperm function., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P8M9", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0044877 protein-containing complex binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0001669 acrosomal vesicle;GO:0005814 centriole", "go_biological_process": "GO:0007286 spermatid development;GO:0046777 protein autophosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O54863-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70481-1", "uniprot_id": [ { "id": "UBR1_MOUSE", "url": "https://www.uniprot.org/uniprot/O70481", "type": "external" } ], "mass": 200240.0, "length": 1757, "protein_name": "E3 ubiquitin-protein ligase UBR1", "gene_name": "Ubr1", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase UBR1", "refseq_ac": [ { "id": "NP_033487", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033487", "type": "external" } ], "gene_names_uniprotkb": "Ubr1", "gene_names_refseq": "Ubr1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase UBR1; 2.3.2.27; N-recognin-1; Ubiquitin-protein ligase E3-alpha-1; Ubiquitin-protein ligase E3-alpha-I", "protein_names_refseq": "E3 alpha; E3 ubiquitin-protein ligase UBR1; N-recognin-1; RING-type E3 ubiquitin transferase UBR1; ubiquitin-protein ligase E3-alpha-1; ubiquitin-protein ligase E3-alpha-I; ubiquitin-protein ligase e3 componen n-recognin", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); cardiovascular system disease (Disease Ontology:DOID:1287); neurodegenerative disease (Disease Ontology:DOID:1289); Johanson-Blizzard syndrome (Disease Ontology:DOID:14694); atherosclerosis (Disease Ontology:DOID:1936)", "pathway": " (mmu:22222); (R-MMU-983168)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;11689692;14585983;15548684;16311597;16606826;18614536;19008229;20173027;25428506;25605945;30084848;30679156;30779550;31219806;34428180;35820727;37057345;40885482;9653112", "class_list": "", "function": "A STAT3-dependent E3 ubiquitin ligase, Ubr1, was responsible for rhodopsin degradation and was up-regulated in the inflamed SOCS3-deficient retinas., [RefSeq, PubMed]; E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (PubMed:11689692, PubMed:14585983, PubMed:16311597, PubMed:19008229). Recognizes and binds proteins bearing specific N-terminal residues (N-degrons) that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (PubMed:11689692, PubMed:14585983, PubMed:16311597, PubMed:19008229). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (PubMed:19008229). Does not ubiquitinate proteins that are acetylated at the N-terminus (By similarity). In contrast, it strongly binds methylated N-degrons (By similarity). Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Identification of Ubr1 as an amino acid sensor of steatosis in liver and muscle., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, 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"0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0CG49-1", "uniprot_id": [ { "id": "UBB_MOUSE", "url": "https://www.uniprot.org/uniprot/P0CG49", "type": "external" } ], "mass": 34369.0, "length": 305, "protein_name": "Polyubiquitin-B", "gene_name": "Ubb", "organism": "Mouse", "refseq_name": "polyubiquitin-B precursor", "refseq_ac": [ { "id": "NP_001300913", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001300913", "type": "external" } ], "gene_names_uniprotkb": "Ubb", "gene_names_refseq": "Rps27a; Uba52; Ubb2; Ubb; Ubc", "protein_names_uniprotkb": "Polyubiquitin-B", "protein_names_refseq": "Polyubiquitin-B; polyubiquitin-B precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:22187); (R-MMU-110312); (R-MMU-110314); (R-MMU-110320); (R-MMU-1169091); (R-MMU-1234176); (R-MMU-1253288); (R-MMU-1295596); (R-MMU-1358803); (R-MMU-156827); (R-MMU-168638); (R-MMU-174048); (R-MMU-174084); (R-MMU-174113); (R-MMU-174154); (R-MMU-174178); (R-MMU-174184); (R-MMU-179409); (R-MMU-1799339); (R-MMU-182971); (R-MMU-187577); (R-MMU-195253); (R-MMU-201681); (R-MMU-202424); (R-MMU-205043); (R-MMU-209543); (R-MMU-209560); (R-MMU-2122948); (R-MMU-2173788); (R-MMU-2173791); (R-MMU-2173795); (R-MMU-2173796); (R-MMU-2467813); (R-MMU-2559580); (R-MMU-2559582); (R-MMU-2559585); (R-MMU-2565942); (R-MMU-2672351); (R-MMU-2871837); (R-MMU-3134975); (R-MMU-349425); (R-MMU-3769402); (R-MMU-382556); (R-MMU-445989); (R-MMU-450302); (R-MMU-450321); (R-MMU-450408); (R-MMU-4608870); (R-MMU-4641257); (R-MMU-4641258); (R-MMU-4641263); (R-MMU-5205685); (R-MMU-532668); (R-MMU-5357905); (R-MMU-5357956); (R-MMU-5358346); (R-MMU-5607761); (R-MMU-5607764); (R-MMU-5610780); (R-MMU-5610785); (R-MMU-5632684); (R-MMU-5654726); (R-MMU-5654727); (R-MMU-5654732); (R-MMU-5654733); (R-MMU-5655862); (R-MMU-5656121); (R-MMU-5656169); (R-MMU-5658442); (R-MMU-5668541); (R-MMU-5675221); (R-MMU-5675482); (R-MMU-5676590); (R-MMU-5684264); (R-MMU-5685942); (R-MMU-5687128); (R-MMU-5689603); (R-MMU-5689877); (R-MMU-5689880); (R-MMU-5689896); (R-MMU-5689901); (R-MMU-5693537); (R-MMU-5693565); (R-MMU-5693607); (R-MMU-5696394); (R-MMU-5696395); (R-MMU-5696397); (R-MMU-5696400); (R-MMU-6781823); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-6783310); (R-MMU-6791226); (R-MMU-6804756); (R-MMU-6804757); (R-MMU-6804760); (R-MMU-6807004); (R-MMU-68867); (R-MMU-68949); (R-MMU-69017); (R-MMU-69231); (R-MMU-69481); (R-MMU-69541); (R-MMU-69601); (R-MMU-72689); (R-MMU-72706); (R-MMU-75815); (R-MMU-8849469); (R-MMU-8852276); (R-MMU-8854050); (R-MMU-8856825); (R-MMU-8856828); (R-MMU-8863795); (R-MMU-8866427); (R-MMU-8866652); (R-MMU-8866654); (R-MMU-8939236); (R-MMU-8939902); (R-MMU-8941858); (R-MMU-8948747); (R-MMU-8948751); (R-MMU-8951664); (R-MMU-901032); (R-MMU-9010553); (R-MMU-9013507); (R-MMU-9020702); (R-MMU-9033241); (R-MMU-909733); (R-MMU-912631); (R-MMU-917729); (R-MMU-917937); (R-MMU-936440); (R-MMU-936964); (R-MMU-937039); (R-MMU-937041); (R-MMU-937042); (R-MMU-937072); (R-MMU-9645460); (R-MMU-9646399); (R-MMU-9648002); (R-MMU-9664873); (R-MMU-9705462); (R-MMU-9706369); (R-MMU-9708530); (R-MMU-975144); (R-MMU-975163); (R-MMU-9755511); (R-MMU-9758274); (R-MMU-975956); (R-MMU-975957); (R-MMU-9762114); (R-MMU-9766229); (R-MMU-9770562); (R-MMU-9824878); (R-MMU-983168); (R-MMU-9861718); (R-MMU-9929356); (R-MMU-9929491); (R-MMU-9931269); (R-MMU-9931295); (R-MMU-9932298); (R-MMU-9954709); (R-MMU-9954714); (R-MMU-9954716); (R-MMU-9958810); (R-MMU-9958825)", "pathway_count": 166, "publication_count": 7, "publication_id_list": "19754430;2159627;21750661;22645316;30016717;33300544;39927985", "class_list": "", "function": "Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling., [UniProtKB, PubMed]; This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene consists of four direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. Pseudogenes of this gene are located on chromosomes 3 and 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P02248;P02249;P02250;P62991;Q29120;Q62317;Q64223;Q8VCH1;Q91887;Q91888;Q9CXY4;Q9CZM0;Q9D1R5;Q9D8D9;Q9ET23;Q9ET24;Q9Z0H9", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0031386 protein tag activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol", "go_biological_process": "GO:0047497 mitochondrion transport along microtubule;GO:0007144 female meiosis I;GO:0060612 adipose tissue development;GO:0048812 neuron projection morphogenesis;GO:0051881 regulation of mitochondrial membrane potential", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P0CG49-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35456-1", "uniprot_id": [ { "id": "UPAR_MOUSE", "url": "https://www.uniprot.org/uniprot/P35456", "type": "external" } ], "mass": 35428.0, "length": 327, "protein_name": "Urokinase plasminogen activator surface receptor", "gene_name": "Plaur", "organism": "Mouse", "refseq_name": "urokinase plasminogen activator surface receptor precursor", "refseq_ac": [ { "id": "NP_035243", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035243", "type": "external" } ], "gene_names_uniprotkb": "Plaur", "gene_names_refseq": "Cd87; Plaur; u-PAR; uPAR", "protein_names_uniprotkb": "Urokinase plasminogen activator surface receptor; U-PAR; uPAR", "protein_names_refseq": "urokinase plasminogen activator receptor; urokinase plasminogen activator surface receptor precursor; urokinase plasminogen activator surface receptor", "tax_id": 10090, "disease": "sinusitis (Disease Ontology:DOID:0050127); alcohol-associated liver disease (Disease Ontology:DOID:0070658); focal segmental glomerulosclerosis 1 (Disease Ontology:DOID:0111128); pre-eclampsia (Disease Ontology:DOID:10591); Lyme disease (Disease Ontology:DOID:11729); cardiovascular system disease (Disease Ontology:DOID:1287); disease of cellular proliferation (Disease Ontology:DOID:14566); status epilepticus (Disease Ontology:DOID:1824); hepatitis B (Disease Ontology:DOID:2043); pulmonary tuberculosis (Disease Ontology:DOID:2957); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); melioidosis (Disease Ontology:DOID:5052); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); myocardial infarction (Disease Ontology:DOID:5844); rheumatoid arthritis (Disease Ontology:DOID:7148); end stage renal disease (Disease Ontology:DOID:783); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677); Crohn's disease (Disease Ontology:DOID:8778); type 2 diabetes mellitus (Disease Ontology:DOID:9352); meningitis (Disease Ontology:DOID:9471); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:18793); (R-MMU-162791); (R-MMU-6798695); (R-MMU-75205); (R-MMU-9855719); (R-MMU-9970672)", "pathway_count": 6, "publication_count": 8, "publication_id_list": "1661735;19667118;20133942;21750661;25428506;37958542;38247863;7929309", "class_list": "glycogene", "function": "GPI-anchored receptor that recruits and activates the urokinase-type plasminogen activator (uPA) at the cell surface. Activated uPA converts plasminogen into plasmin, initiating extracellular matrix degradation and remodeling. Also binds the extracellular matrix protein vitronectin, promoting cell-matrix adhesion and indirectly integrin signaling. This dual interaction coordinates dynamic changes in cell migration, proliferation, and tissue remodeling., [UniProtKB, UniProtKB]; Role of Formyl Peptide Receptors and beta-Arrestin-1 in suPAR Signal Transduction in Mouse Podocytes: Interactions with alphaVbeta3-Integrin. Publication Status: Online-Only, [RefSeq, PubMed]; Urokinase-Type Plasminogen Activator Receptor Regulates Prosurvival and Angiogenic Properties of Cardiac Mesenchymal Stromal Cells. 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P46", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "7523108", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P38642-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38643-1", "uniprot_id": [ { "id": "UF05_MOUSE", "url": "https://www.uniprot.org/uniprot/P38643", "type": "external" } ], "mass": 1330.0, "length": 11, "protein_name": "Unknown protein from 2D-PAGE of fibroblasts", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Unknown protein from 2D-PAGE of fibroblasts; P48", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "7523108", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P38643-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38644-1", "uniprot_id": [ { "id": "UF06_MOUSE", "url": "https://www.uniprot.org/uniprot/P38644", "type": "external" } ], "mass": 817.0, "length": 8, "protein_name": "Unknown protein from 2D-PAGE of fibroblasts", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Unknown protein from 2D-PAGE of fibroblasts; P50", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "7523108", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P38644-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P42682-1", "uniprot_id": [ { "id": "TXK_MOUSE", "url": "https://www.uniprot.org/uniprot/P42682", "type": "external" } ], "mass": 61108.0, "length": 527, "protein_name": "Tyrosine-protein kinase TXK", "gene_name": "Txk", "organism": "Mouse", "refseq_name": "tyrosine-protein kinase TXK isoform 1", "refseq_ac": [ { "id": "NP_001116226", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116226", "type": "external" } ], "gene_names_uniprotkb": "Txk; Rlk", "gene_names_refseq": "A130089B16Rik; Btkl; PTK-RL-18; PTK4; Rlk; Txk", "protein_names_uniprotkb": "Tyrosine-protein kinase TXK; 2.7.10.2; PTK-RL-18; Resting lymphocyte kinase", "protein_names_refseq": "resting lymphocyte kinase; tyrosine-protein kinase TXK isoform 1; tyrosine-protein kinase TXK", "tax_id": 10090, "disease": "", "pathway": " (mmu:22165); (R-MMU-2871809)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10562318;10587356;10660534;11353545;17947660;18941202;19290923;21750661;26466958;34036382;34428180;7542761;7579892;7829530;9891083", "class_list": "", "function": "Effects of Txkmediated activation of NFkappaB signaling pathway on neurological deficit and oxidative stress after ischemiareperfusion in rats., [RefSeq, PubMed]; Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation leads to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Also contributes to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskeleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with PARP1 and EEF1A1 (By similarity). Within the complex, phosphorylates both PARP1 and EEF1A1 (By similarity). Also phosphorylates key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr-201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Taken together, these data indicate that ITK plus RLK inhibition may have therapeutic potential in Th1-mediated inflammatory diseases., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" } ], "go_molecular_function": "GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006468 protein phosphorylation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0050852 T cell receptor signaling pathway;GO:0001819 positive regulation of cytokine production", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P42682-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55144-1", "uniprot_id": [ { "id": "TYRO3_MOUSE", "url": "https://www.uniprot.org/uniprot/P55144", "type": "external" } ], "mass": 96208.0, "length": 880, "protein_name": "Tyrosine-protein kinase receptor TYRO3", "gene_name": "Tyro3", "organism": "Mouse", "refseq_name": "tyrosine-protein kinase receptor TYRO3 isoform B", "refseq_ac": [ { "id": "NP_001277729", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277729", "type": "external" } ], "gene_names_uniprotkb": "Tyro3; Dtk; Rse; Tif", "gene_names_refseq": "Brt; Dtk; Etk-2; Rse; Sky; TK19-2; Tif; Tyro3; etk2/tyro3; tk19-1", "protein_names_uniprotkb": "Tyrosine-protein kinase receptor TYRO3; 2.7.10.1; Etk2/tyro3; TK19-2; Tyrosine-protein kinase DTK; Tyrosine-protein kinase RSE; Tyrosine-protein kinase TIF", "protein_names_refseq": "receptor tyrosine kinase; tyrosine-protein kinase DTK; tyrosine-protein kinase RSE; tyrosine-protein kinase TIF; tyrosine-protein kinase receptor TYRO3 isoform B; tyrosine-protein kinase receptor TYRO3", "tax_id": 10090, "disease": "", "pathway": " (mmu:22174)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "10.1101/2023.09.13.557529;10227296;10627473;15650770;19349973;20363878;20978472;21084607;21183079;21291561;30084848;34428180;37537628;37678714;7511603;7723626;7784069;7857657;8058320;8108111;8108112;8889809", "class_list": "", "function": "Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Receptor tyrosine kinases Tyro3, Axl, and Mertk differentially contribute to antibody-induced arthritis. Erratum:[Cell Commun Signal. 2023 Aug 31;21(1):225. doi: 10.1186/s12964-023-01293-z. PMID: 37653485] Publication Status: Online-Only, [RefSeq, PubMed]; Tyro3 receptor tyrosine kinase contributes to pathogenic phenotypes of fibroblast-like synoviocytes in rheumatoid arthritis and disturbs immune cell balance in experimental arthritis., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "O09070;O09080;P70285;Q60752;Q62482;Q62483;Q62484;Q6NZM6;Q78E85;Q78E87", "ec_number_list": [ { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" } ], "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0001618 virus receptor activity;GO:0004714 transmembrane receptor protein tyrosine kinase activity;GO:0043548 phosphatidylinositol 3-kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0043235 receptor complex", "go_biological_process": "GO:0001779 natural killer cell differentiation;GO:0006468 protein phosphorylation;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "P55144-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56501-1", "uniprot_id": [ { "id": "UCP3_MOUSE", "url": "https://www.uniprot.org/uniprot/P56501", "type": "external" } ], "mass": 33911.0, "length": 308, "protein_name": "Putative mitochondrial transporter UCP3", "gene_name": "Ucp3", "organism": "Mouse", "refseq_name": "putative mitochondrial transporter UCP3", "refseq_ac": [ { "id": "NP_033490", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033490", "type": "external" } ], "gene_names_uniprotkb": "Ucp3; Slc25a9", "gene_names_refseq": "Slc25a9; UCP-3; Ucp3", "protein_names_uniprotkb": "Putative mitochondrial transporter UCP3; Solute carrier family 25 member 9; UCP 3; Uncoupling protein 3", "protein_names_refseq": "mitochondrial uncoupling protein 3; putative mitochondrial transporter UCP3; solute carrier family 25 member 9", "tax_id": 10090, "disease": "hypocholesteremia (Disease Ontology:DOID:0061212); hypertension (Disease Ontology:DOID:10763); prediabetes syndrome (Disease Ontology:DOID:11716); hypothyroidism (Disease Ontology:DOID:1459); coronary restenosis (Disease Ontology:DOID:4247); congestive heart failure (Disease Ontology:DOID:6000); hyperthyroidism (Disease Ontology:DOID:7998); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); diabetic neuropathy (Disease Ontology:DOID:9743); obesity (Disease Ontology:DOID:9970); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (mmu:22229); (R-MMU-167826)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10066417;10748195;10748196;11707458;20363757;26915802;29212043;35452152;36114012;38254621;39927985;9600108;9666083", "class_list": "", "function": "Ablation of uncoupling protein 3 affects interrelated factors leading to lipolysis and insulin resistance in visceral white adipose tissue., [RefSeq, PubMed]; Overexpression of UCP3 decreases mitochondrial efficiency in mouse skeletal muscle in vivo., [RefSeq, PubMed]; Putative transmembrane transporter that plays a role in mitochondrial metabolism via an as yet unclear mechanism (PubMed:10748195, PubMed:10748196). Originally, this mitochondrial protein was thought to act as a proton transmembrane transporter from the mitochondrial intermembrane space into the matrix, causing proton leaks through the inner mitochondrial membrane, thereby uncoupling mitochondrial membrane potential generation from ATP synthesis (PubMed:29212043). However, this function is controversial and uncoupling may not be the function, or at least not the main function, but rather a consequence of more conventional metabolite transporter activity (PubMed:11707458, PubMed:20363757)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Uncoupling Protein 3 Catalyzes the Exchange of C4 Metabolites Similar to UCP2. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88293", "ec_number_list": [], "go_molecular_function": "GO:0015078 proton transmembrane transporter activity;GO:0017077 oxidative phosphorylation uncoupler activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:1901373 lipid hydroperoxide transport;GO:0000303 response to superoxide;GO:0006631 fatty acid metabolic process;GO:0007584 response to nutrient;GO:0009409 response to cold", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P56501-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P57080-1", "uniprot_id": [ { "id": "UBP25_MOUSE", "url": "https://www.uniprot.org/uniprot/P57080", "type": "external" } ], "mass": 121420.0, "length": 1055, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 25", "gene_name": "Usp25", "organism": "Mouse", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 25", "refseq_ac": [ { "id": "NP_038946", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038946", "type": "external" } ], "gene_names_uniprotkb": "Usp25", "gene_names_refseq": "Usp25", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 25; 3.4.19.12; Deubiquitinating enzyme 25; Ubiquitin thioesterase 25; Ubiquitin-specific-processing protease 25; mUSP25", "protein_names_refseq": "deubiquitinating enzyme 25; mUSP25; ubiquitin carboxyl-terminal hydrolase 25; ubiquitin specific protease 25; ubiquitin thioesterase 25; ubiquitin thiolesterase 25; ubiquitin-specific-processing protease 25", "tax_id": 10090, "disease": "", "pathway": " (mmu:30940); (R-MMU-5689880)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;10644437;16501887;21750661;23042150;26305951;27129230;30084848;31219806;34428180;37339955;38521787;38616174;38875478;39627609", "class_list": "", "function": "Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions in various biological processes including inflammation, immune response. Modulates the Wnt/beta-catenin pathway by deubiquitinating and stabilizing tankyrases TNKS1 and TNKS2. Regulates KEAP1-NRF2 axis in the defense against oxidative assaults by deubiquitinating KEAP1 and protecting it from degradation leading to degradation of the NRF2 transcription factor that is responsible for mounting an anti-oxidation gene expression program. Positively regulates RNA virus-induced innate signaling by interacting with and deubiquitinating ERLIN1 and ERLIN2. In turn, restricts virus production by regulating cholesterol biosynthetic flux. Acts as a negative regulator of interleukin-17-mediated signaling and inflammation through the removal of 'Lys-63'-linked ubiquitination of TRAF5 and TRAF6. Prevents the ubiquitination and degradation of TRAF3 to reduce the phosphorylation levels of JNK and P38, the secretion of IL-1B and to induce endotoxin tolerance., [UniProtKB, UniProtKB]; Expression of USP25 associates with fibrosis, inflammation and metabolism changes in IgG4-related disease. Publication Status: Online-Only, [RefSeq, PubMed]; The muscle-specific isoform (USP25m) may have a role in the regulation of muscular differentiation and function., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; USP25 attenuates anti-GBM nephritis in mice by negative feedback regulation of Th17 cell differentiation., [RefSeq, PubMed]; USP25 is a deubiquitinating enzyme (DUB) that negatively regulates IL-17-triggered signaling., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q80ZT9", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" } ], "go_molecular_function": "GO:0051117 ATPase binding;GO:0031625 ubiquitin protein ligase binding;GO:0004843 cysteine-type deubiquitinase activity;GO:0032183 SUMO binding;GO:0101005 deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0000502 proteasome complex", "go_biological_process": "GO:0016071 mRNA metabolic process;GO:0006955 immune response;GO:0006979 response to oxidative stress;GO:0016579 protein deubiquitination;GO:0070536 protein K63-linked deubiquitination", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P57080-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61080-1", "uniprot_id": [ { "id": "UB2D1_MOUSE", "url": "https://www.uniprot.org/uniprot/P61080", "type": "external" } ], "mass": 16602.0, "length": 147, "protein_name": "Ubiquitin-conjugating enzyme E2 D1", "gene_name": "Ube2d1", "organism": "Mouse", "refseq_name": "ubiquitin-conjugating enzyme E2 D1 isoform 1", "refseq_ac": [ { "id": "NP_663395", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663395", "type": "external" } ], "gene_names_uniprotkb": "Ube2d1", "gene_names_refseq": "UBCH5; Ube2d1", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 D1; (E3-independent) E2 ubiquitin-conjugating enzyme D1; 2.3.2.23; 2.3.2.24; E2 ubiquitin-conjugating enzyme D1; Ubiquitin carrier protein D1; Ubiquitin-conjugating enzyme E2(17)KB 1; Ubiquitin-conjugating enzyme E2-17 kDa 1; Ubiquitin-protein ligase D1", "protein_names_refseq": "(E3-independent) E2 ubiquitin-conjugating enzyme D1; E2 ubiquitin-conjugating enzyme D1; E2(17)KB 1; ubiquitin carrier protein D1; ubiquitin-conjugating enzyme E2 D1 isoform 1; ubiquitin-conjugating enzyme E2(17)KB 1; ubiquitin-conjugating enzyme E2-17 kDa 1; ubiquitin-conjugating enzyme E2D 1, UBC4/5 homolog; ubiquitin-protein ligase D1", "tax_id": 10090, "disease": "", "pathway": " (mmu:216080); (R-MMU-1234176); (R-MMU-141430); (R-MMU-174048); (R-MMU-174084); (R-MMU-174154); (R-MMU-174178); (R-MMU-174184); (R-MMU-176407); (R-MMU-176408); (R-MMU-176409); (R-MMU-176412); (R-MMU-179409); (R-MMU-201451); (R-MMU-202424); (R-MMU-2173795); (R-MMU-2467813); (R-MMU-2559582); (R-MMU-2871837); (R-MMU-5357905); (R-MMU-5607764); (R-MMU-5689896); (R-MMU-68867); (R-MMU-69017); (R-MMU-8866652); (R-MMU-8866654); (R-MMU-8951664); (R-MMU-9033241); (R-MMU-937041); (R-MMU-9705462); (R-MMU-983168); (R-MMU-9954709); (R-MMU-9954716)", "pathway_count": 33, "publication_count": 3, "publication_id_list": "15139022;31219806;39927985", "class_list": "", "function": "Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4., [UniProtKB, UniProtKB]; Significantly elevated levels of SFT/UbcH5A mRNA in the neonatal mouse and its localization to choroid plexus suggest that this factor may contribute to the rapid rate of brain iron uptake that occurs in the early postnatal period, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.367", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.367", "type": "external" }, { "id": "6.2.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.64", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "1.14.11.29", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.29", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0032991 protein-containing complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0031398 positive regulation of protein ubiquitination;GO:0031669 cellular response to nutrient levels;GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P61080-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62838-1", "uniprot_id": [ { "id": "UB2D2_MOUSE", "url": "https://www.uniprot.org/uniprot/P62838", "type": "external" } ], "mass": 16735.0, "length": 147, "protein_name": "Ubiquitin-conjugating enzyme E2 D2", "gene_name": "Ube2d2a; Ube2d2", "organism": "Mouse", "refseq_name": "ubiquitin-conjugating enzyme E2 D2", "refseq_ac": [ { "id": "NP_064296", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064296", "type": "external" } ], "gene_names_uniprotkb": "Ube2d2a; Ube2d2; Ubc4; Ubch4; Ubch5b; Ube2d2a", "gene_names_refseq": "1500034D03Rik; Ubc2e; Ube2d2a; Ube2d2; ubc4", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 D2; (E3-independent) E2 ubiquitin-conjugating enzyme D2; 2.3.2.23; 2.3.2.24; E2 ubiquitin-conjugating enzyme D2; Ubiquitin carrier protein D2; Ubiquitin-conjugating enzyme E2(17)KB 2; Ubiquitin-conjugating enzyme E2-17 kDa 2; Ubiquitin-protein ligase D2", "protein_names_refseq": "(E3-independent) E2 ubiquitin-conjugating enzyme D2; E2 ubiquitin-conjugating enzyme D2; E2(17)KB 2; ubiquitin carrier protein D2; ubiquitin conjugating enzyme 2e; ubiquitin-conjugating enzyme E2 D2; ubiquitin-conjugating enzyme E2(17)KB 2; ubiquitin-conjugating enzyme E2-17 kDa 2; ubiquitin-conjugating enzyme E2D 2; ubiquitin-protein ligase D2", "tax_id": 10090, "disease": "", "pathway": " (mmu:56550); (R-MMU-1234176); (R-MMU-202424); (R-MMU-2871837); (R-MMU-5205685); (R-MMU-5357905); (R-MMU-5607764); (R-MMU-8866652); (R-MMU-8866654); (R-MMU-8951664); (R-MMU-9033241); (R-MMU-937041); (R-MMU-9705462); (R-MMU-983168); (R-MMU-9954709); (R-MMU-9954716)", "pathway_count": 16, "publication_count": 5, "publication_id_list": "12036302;17576800;21750661;31219806;34428180", "class_list": "", "function": "Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and SQSTM1 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by RIGI in response to viral infection. Essential for viral activation of IRF3., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P51669", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "6.2.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.64", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "1.14.11.29", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.29", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity;GO:0061631 ubiquitin conjugating enzyme activity;GO:0016740 transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006511 ubiquitin-dependent protein catabolic process;GO:0051865 protein autoubiquitination;GO:0070936 protein K48-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P62838-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63072-1", "uniprot_id": [ { "id": "UBD_MOUSE", "url": "https://www.uniprot.org/uniprot/P63072", "type": "external" } ], "mass": 18376.0, "length": 162, "protein_name": "Ubiquitin D", "gene_name": "Ubd", "organism": "Mouse", "refseq_name": "ubiquitin D", "refseq_ac": [ { "id": "NP_075626", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075626", "type": "external" } ], "gene_names_uniprotkb": "Ubd; Fat10", "gene_names_refseq": "FAT10; Ubd", "protein_names_uniprotkb": "Ubiquitin D; Diubiquitin; Ubiquitin-like protein FAT10", "protein_names_refseq": "Diubiquitin; ubiquitin D; ubiquitin-like protein FAT10", "tax_id": 10090, "disease": "metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (mmu:24108); (R-MMU-8951664)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "11445583;15831455;16495380;16782901;17889673;18280469;19959714;34428180;36778114;36905264;37188463;37926201", "class_list": "", "function": "Evaluating the role of Ubiquitin D gene expression in types of leukemia. Publication Status: Online-Only, [RefSeq, PubMed]; FAT10 and NUB1L cooperate to activate the 26S proteasome. Publication Status: Online-Only, [RefSeq, PubMed]; Immunohistochemical studies demonstrated increased FAT10 expression in a model of HIV-associated nephropathy., [RefSeq, PubMed]; The ubiquitin-like modifier FAT10 is induced in MASLD and impairs the lipid-regulatory activity of PPARalpha., [RefSeq, PubMed]; Ubiquitin like protein FAT10 repressed cardiac fibrosis after myocardial ischemic via mediating degradation of Smad3 dependent on FAT10-proteasome system. Publication Status: Online-Only, [RefSeq, PubMed]; Ubiquitin-like protein modifier which can be covalently attached to target proteins and subsequently leads to their degradation by the 26S proteasome, in a NUB1-dependent manner. Conjugation to the target protein is activated by UBA6 via adenylation of its C-terminal glycine (By similarity). Probably functions as a survival factor. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T-cell responses. Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization of MAD2L1 during the prometaphase stage of the cell cycle. May be involved in the formation of aggresomes when proteasome is saturated or impaired. Mediates apoptosis in a caspase-dependent manner, especially in renal epithelium and tubular cells during renal diseases., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4FJZ5;Q9WV10", "ec_number_list": [], "go_molecular_function": "GO:0070628 proteasome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0001650 fibrillar center;GO:0016235 aggresome", "go_biological_process": "GO:0034612 response to tumor necrosis factor;GO:0043065 positive regulation of apoptotic process;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P63072-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63147-1", "uniprot_id": [ { "id": "UBE2B_MOUSE", "url": "https://www.uniprot.org/uniprot/P63147", "type": "external" } ], "mass": 17312.0, "length": 152, "protein_name": "Ubiquitin-conjugating enzyme E2 B", "gene_name": "Ube2b", "organism": "Mouse", "refseq_name": "ubiquitin-conjugating enzyme E2 B isoform 1", "refseq_ac": [ { "id": "NP_033484", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033484", "type": "external" } ], "gene_names_uniprotkb": "Ube2b; Rad6b", "gene_names_refseq": "E2-14k; E214K; HR6B; Rad6b; Ube2b; mHR6B", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 B; 2.3.2.23; E2 ubiquitin-conjugating enzyme B; E214K; HR6B; RAD6 homolog B; Ubiquitin carrier protein B; Ubiquitin-protein ligase B; mHR6B", "protein_names_refseq": "E2 ubiquitin-conjugating enzyme B; RAD6 homolog B; ubiquitin carrier protein B; ubiquitin-conjugating enzyme E2 B isoform 1; ubiquitin-conjugating enzyme E2B, RAD6 homology; ubiquitin-protein ligase B", "tax_id": 10090, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (mmu:22210); (R-MMU-110314); (R-MMU-8866652); (R-MMU-8866654); (R-MMU-983168)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "14585983;32868078;34428180;34774969;8797826", "class_list": "", "function": "E2 ubiquitin-conjugating enzyme that accepts ubiquitin from the ubiquitin-activating enzyme E1 and transfers it to a E3 ubiquitin-protein ligase (PubMed:14585983). In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination (By similarity). Together with the E3 enzyme BRE1 (RNF20 and/or RNF40), plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1 (By similarity). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation (By similarity). May play a role in DNA repair (By similarity). Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164' (By similarity). In association with the E3 enzyme UBR4, is involved in N-end rule-dependent protein degradation (By similarity). May be involved in neurite outgrowth (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Loss of RAD6B induces degeneration of the cochlea in mice., [RefSeq, PubMed]; The Role of RAD6B and PEDF in Retinal Degeneration., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P23567;Q3UGS2;Q9D0J6", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "6.2.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.64", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0031625 ubiquitin protein ligase binding;GO:0004842 ubiquitin-protein transferase activity;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0000785 chromatin;GO:0005657 replication fork", "go_biological_process": "GO:1901874 negative regulation of post-translational protein modification;GO:0001701 in utero embryonic development;GO:0006281 DNA repair;GO:0007283 spermatogenesis;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P63147-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0KL01-1", "uniprot_id": [ { "id": "UBX2B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q0KL01", "type": "external" } ], "mass": 37444.0, "length": 331, "protein_name": "UBX domain-containing protein 2B", "gene_name": "Ubxn2b", "organism": "Mouse", "refseq_name": "UBX domain-containing protein 2B", "refseq_ac": [ { "id": "NP_080810", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080810", "type": "external" } ], "gene_names_uniprotkb": "Ubxn2b", "gene_names_refseq": "3110003A22Rik; 6430407D20Rik; Ubxn2b; p37", "protein_names_uniprotkb": "UBX domain-containing protein 2B; NSFL1 cofactor p37; p97 cofactor p37", "protein_names_refseq": "NSFL1 cofactor p37; UBX domain-containing protein 2B; p97 cofactor p37", "tax_id": 10090, "disease": "", "pathway": " (mmu:68053)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15345747;17141156;23649807;34428180", "class_list": "", "function": "Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required, but not its deubiquitinating activity. Together with NSFL1C/p47, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BGY8;Q8CCQ0;Q9CZA8", "ec_number_list": [], "go_molecular_function": "GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0031616 spindle pole centrosome", "go_biological_process": "GO:0031468 nuclear membrane reassembly;GO:0043335 protein unfolding;GO:0000045 autophagosome assembly;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0061025 membrane fusion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q0KL01-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q14BU0-1", "uniprot_id": [ { "id": "UCMA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q14BU0", "type": "external" } ], "mass": 16579.0, "length": 138, "protein_name": "Unique cartilage matrix-associated protein", "gene_name": "Ucma", "organism": "Mouse", "refseq_name": "upper zone of growth plate and cartilage matrix-associated protein isoform b preproprotein", "refseq_ac": [ { "id": "NP_001107030", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107030", "type": "external" } ], "gene_names_uniprotkb": "Ucma", "gene_names_refseq": "1110017I16Rik; Grp; Ucma", "protein_names_uniprotkb": "Unique cartilage matrix-associated protein; GRP; Gla-rich protein; Upper zone of growth plate and cartilage matrix associated protein", "protein_names_refseq": "Gla-rich protein; unique cartilage matrix-associated protein; upper zone of growth plate and cartilage matrix associated protein; upper zone of growth plate and cartilage matrix-associated protein isoform b preproprotein", "tax_id": 10090, "disease": "", "pathway": " (mmu:68527)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17707622;18156182;19819238;30791984;32768190", "class_list": "", "function": "Downstream target genes of Ucma were found in osteoblasts by microarray analysis. 45 genes including Fbn2 were dependent on Ucma overexpression or knockdown. Fbn2 expression was proportional to Ucma expression in osteoblasts., [RefSeq, PubMed]; Four alternative splicing variants derived from the mouse Ucma/GRP gene in chondrocytes were identified and their expression and subcellular localization during chondrogenesis was determined., [RefSeq, PubMed]; May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface., [UniProtKB, PubMed]; The present data strongly suggest an important function of Ucma in the early phase of chondrocyte differentiation., [RefSeq, PubMed]; This gene encodes chondrocyte-specific, highly charged proteins that are abundantly expressed during the early stages of chondrogenesis. The encoded protein undergoes proteolytic processing to generate a mature protein that is secreted into the extracellular matrix. The glutamic acid residues in the encoded protein undergo gamma carboxylation in a vitamin K-dependent manner. Despite the implied role in calcification and ossification, mice lacking the encoded protein do not display significant defects in the skeletal development. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo a similar proteolytic processing to generate mature proteins. [provided by RefSeq, Aug 2015]., [RefSeq]; Ucma may be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells, [RefSeq, PubMed]; Unique cartilage matrix-associated protein inhibits the migratory and invasive potential of triple-negative breast cancer., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "C9W8R6;C9W8R7;C9W8R8;C9W8R9;Q9D1A9", "ec_number_list": [], "go_molecular_function": "GO:0036122 BMP binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005856 cytoskeleton", "go_biological_process": "GO:0045668 negative regulation of osteoblast differentiation;GO:0048706 embryonic skeletal system development;GO:0060392 negative regulation of SMAD protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q14BU0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UWQ3-1", "uniprot_id": [ { "id": "UB2FB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UWQ3", "type": "external" } ], "mass": 21352.0, "length": 185, "protein_name": "NEDD8-conjugating enzyme UBE2F-B", "gene_name": "Ube2fb", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ube2fb; Gm5434", "gene_names_refseq": "", "protein_names_uniprotkb": "NEDD8-conjugating enzyme UBE2F-B; 2.3.2.34; NEDD8 carrier protein UBE2F-B; NEDD8 protein ligase UBE2F-B; RING-type E3 NEDD8 transferase UBE2F-B; Ubiquitin-conjugating enzyme E2 F-B", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. Together with the E3 ubiquitin ligase RNF7/RBX2, specifically neddylates cullin-5 (CUL5). Does not neddylate CUL1, CUL2, CUL3, CUL4A or CUL4B. Mediates neddylation of the CUL9-RBX1 complex (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0061654 NEDD8 conjugating enzyme activity;GO:0005524 ATP binding;GO:0019788 NEDD8 transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0045116 protein neddylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3UWQ3-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61068-1", "uniprot_id": [ { "id": "U17PA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61068", "type": "external" } ], "mass": 59073.0, "length": 526, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 17-like protein A", "gene_name": "Usp17la", "organism": "Mouse", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 17-like protein A", "refseq_ac": [ { "id": "NP_031913", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031913", "type": "external" } ], "gene_names_uniprotkb": "Usp17la; Dub-1; Dub1", "gene_names_refseq": "Dub1; USP17-A; Usp17la", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 17-like protein A; 3.4.19.12; Deubiquitinating enzyme 1; USP17-A; Ubiquitin carboxyl-terminal hydrolase DUB-1; Ubiquitin thioesterase DUB-1; Ubiquitin-specific-processing protease DUB-1", "protein_names_refseq": "deubiquitinating enzyme 1; ubiquitin carboxyl-terminal hydrolase 17-like protein A; ubiquitin carboxyl-terminal hydrolase DUB-1; ubiquitin thioesterase DUB-1; ubiquitin thiolesterase DUB-1; ubiquitin-specific-processing protease DUB-1", "tax_id": 10090, "disease": "congenital heart disease (Disease Ontology:DOID:1682); primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (mmu:13531); (R-MMU-5689880)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "18980247;30084848;8622927;8756639", "class_list": "", "function": "Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Has deubiquitinating enzyme activity for DNAH5, suggesting a role in the regulation of DNAH5 degradation by the ubiquitin-proteasome pathway. Has growth-suppressing activity; induces arrest in G1 phase upon controlled expression., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.4.26.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.26.1", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0004843 cysteine-type deubiquitinase activity;GO:0005540 hyaluronic acid binding;GO:0106222 lncRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0031647 regulation of protein stability;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q61068-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62302-1", "uniprot_id": [ { "id": "TX261_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62302", "type": "external" } ], "mass": 22524.0, "length": 196, "protein_name": "Protein TEX261", "gene_name": "Tex261", "organism": "Mouse", "refseq_name": "protein TEX261", "refseq_ac": [ { "id": "NP_033383", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033383", "type": "external" } ], "gene_names_uniprotkb": "Tex261", "gene_names_refseq": "3110001O07Rik; TEG-261; Tex261", "protein_names_uniprotkb": "Protein TEX261; Testis-expressed protein 261", "protein_names_refseq": "protein TEX261; testis-expressed protein 261; testis-expressed sequence 261 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:21766)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17803966;34428180;37507081;8703127;9464256", "class_list": "", "function": "These findings suggest that Tex261 modulates the excitotoxic cell death induced by NMDA receptor activation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0097020 COPII receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q62302-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63886-1", "uniprot_id": [ { "id": "UD11_MOUSE", "url": "https://www.uniprot.org/uniprot/Q63886", "type": "external" } ], "mass": 60047.0, "length": 535, "protein_name": "UDP-glucuronosyltransferase 1A1", "gene_name": "Ugt1a1", "organism": "Mouse", "refseq_name": "UDP-glucuronosyltransferase 1A1 precursor", "refseq_ac": [ { "id": "NP_964007", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_964007", "type": "external" } ], "gene_names_uniprotkb": "Ugt1a1; Ugt1", "gene_names_refseq": "Gnt1; UDPGT 1-1; UGT1A01; Udpgt-1a; Ugt1a1; UgtBr1", "protein_names_uniprotkb": "UDP-glucuronosyltransferase 1A1; 2.4.1.17; UDP-glucuronosyltransferase 1-1; UDPGT 1-1; UGT1*1; UGT1-01; UGT1.1; UGT1A1; UGTBR1", "protein_names_refseq": "UDP-glucuronosyltransferase 1 family, member 1; UDP-glucuronosyltransferase 1-1; UDP-glucuronosyltransferase 1A1 precursor; UDP-glucuronosyltransferase 1A1; UDPGT; UGT1*1; UGT1-01; UGT1.1", "tax_id": 10090, "disease": "cholelithiasis (Disease Ontology:DOID:10211); cholecystolithiasis (Disease Ontology:DOID:11151); endometrial cancer (Disease Ontology:DOID:1380); breast cancer (Disease Ontology:DOID:1612); hepatitis B (Disease Ontology:DOID:2043); ovarian cancer (Disease Ontology:DOID:2394); Gilbert syndrome (Disease Ontology:DOID:2739); bilirubin metabolic disorder (Disease Ontology:DOID:2741); Crigler-Najjar syndrome (Disease Ontology:DOID:3803); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hyperthyroidism (Disease Ontology:DOID:7998); myeloid leukemia (Disease Ontology:DOID:8692); Crohn's disease (Disease Ontology:DOID:8778); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:394436); (R-MMU-156588); (R-MMU-189483); (R-MMU-9749641); (R-MMU-9753281)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;14672974;32093886;33961837;34428180;36720308;36830621;37453647;38577195;40997131;8464825", "class_list": "glycogene;glycosyltransferase", "function": "Hetero-oligomer formation of mouse UDP-glucuronosyltransferase (UGT) 2b1 and 1a1 results in the gain of glucuronidation activity towards morphine, an activity which is absent in homo-oligomers of either UGT., [RefSeq, PubMed]; Oral arsenic administration to humanizedUDP-glucuronosyltransferase1 neonatal mice induces UGT1A1 through a dependence on Nrf2 and PXR., [RefSeq, PubMed]; Suppressing Hepatic UGT1A1 Increases Plasma Bilirubin, Lowers Plasma Urobilin, Reorganizes Kinase Signaling Pathways and Lipid Species and Improves Fatty Liver Disease. Publication Status: Online-Only, [RefSeq, PubMed]; UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol, estrone and estriol. Involved in the glucuronidation of bilirubin, a degradation product occurring in the normal catabolic pathway that breaks down heme in vertebrates. Involved in the glucuronidation of arachidonic acid (AA) and AA-derived eicosanoids including 15-HETE, 20-HETE, PGB1 and F2-isoprostane (8-iso-PGF2alpha). Involved in the glucuronidation of the phytochemical ferulic acid at the phenolic or the carboxylic acid group. Also catalyzes the glucuronidation the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties. Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist losartan, a drug which can inhibit the effect of angiotensin II. Involved in the biotransformation of 7-ethyl-10-hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan., [UniProtKB, UniProtKB]; UGT1A1 dysfunction increases liver burden and aggravates hepatocyte damage caused by long-term bilirubin metabolism disorder., [RefSeq, PubMed]; Uridine diphosphate glucuronosyltransferase 1A1 prevents the progression of liver injury., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 90, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 15, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q561M6;Q6XL50", "ec_number_list": [ { "id": "2.4.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.17", "type": "external" }, { "id": "2.4.1.170", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.170", "type": "external" }, { "id": "2.4.1.185", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.185", "type": "external" } ], "go_molecular_function": "GO:0008194 UDP-glycosyltransferase activity;GO:0004857 enzyme inhibitor activity;GO:0019899 enzyme binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0034663 endoplasmic reticulum chaperone complex;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0008210 estrogen metabolic process;GO:0046685 response to arsenic-containing substance;GO:0035733 hepatic stellate cell activation;GO:0001889 liver development;GO:0006468 protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q63886-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000010000.101.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P3B2-1", "uniprot_id": [ { "id": "UBAD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P3B2", "type": "external" } ], "mass": 18910.0, "length": 176, "protein_name": "UBA-like domain-containing protein 1", "gene_name": "Ubald1", "organism": "Mouse", "refseq_name": "UBA-like domain-containing protein 1", "refseq_ac": [ { "id": "NP_663334", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663334", "type": "external" } ], "gene_names_uniprotkb": "Ubald1; Fam100a", "gene_names_refseq": "1500031H01Rik; Fam100a; Ubald1", "protein_names_uniprotkb": "UBA-like domain-containing protein 1", "protein_names_refseq": "UBA-like domain-containing protein 1; family with sequence similarity 100, member A; protein FAM100A", "tax_id": 10090, "disease": "", "pathway": " (mmu:207740)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "26495903", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q0P6G5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6P3B2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PGH0-1", "uniprot_id": [ { "id": "UBTD2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PGH0", "type": "external" } ], "mass": 26144.0, "length": 234, "protein_name": "Ubiquitin domain-containing protein 2", "gene_name": "Ubtd2", "organism": "Mouse", "refseq_name": "ubiquitin domain-containing protein 2 isoform 1", "refseq_ac": [ { "id": "NP_776145", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776145", "type": "external" } ], "gene_names_uniprotkb": "Ubtd2", "gene_names_refseq": "4930571L24; 9630054F20Rik; Ubtd2", "protein_names_uniprotkb": "Ubiquitin domain-containing protein 2", "protein_names_refseq": "ubiquitin domain-containing protein 2 isoform 1; ubiquitin domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:327900)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AAY6;Q8C5Y1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6PGH0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6ZQM8-1", "uniprot_id": [ { "id": "UD17_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6ZQM8", "type": "external" } ], "mass": 59758.0, "length": 531, "protein_name": "UDP-glucuronosyltransferase 1A7", "gene_name": "Ugt1a7", "organism": "Mouse", "refseq_name": "UDP-glucuronosyltransferase 1A7 precursor", "refseq_ac": [ { "id": "NP_964004", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_964004", "type": "external" } ], "gene_names_uniprotkb": "Ugt1a7; Ugt1a7c", "gene_names_refseq": "A10'; A13; UGT1A7; Ugt1a10; Ugt1a7c", "protein_names_uniprotkb": "UDP-glucuronosyltransferase 1A7; 2.4.1.17; UDP-glucuronosyltransferase 1-7C; UDP-glucuronosyltransferase 1A7C; UDPGT 1-7C; UGT1*7C; UGT1-07C; UGT1.7C; UGT1A7", "protein_names_refseq": "UDP glucuronosyltransferase 1 family, polypeptide A10; UDP glycosyltransferase 1 family, polypeptide A10; UDP-glucuronosyltransferase 1-7C; UDP-glucuronosyltransferase 1A7 precursor; UDP-glucuronosyltransferase 1A7C; UDP-glucuronosyltransferase 1A7; UDPGT 1-7C; UGT1*7C; UGT1-07C; UGT1.7C", "tax_id": 10090, "disease": "pancreatic cancer (Disease Ontology:DOID:1793); cholangiocarcinoma (Disease Ontology:DOID:4947); alcoholic pancreatitis (Disease Ontology:DOID:4988); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:394432); (R-MMU-156588); (R-MMU-9749641); (R-MMU-9753281)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "14672974;34428180;36210013", "class_list": "glycogene;glycosyltransferase", "function": "UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous estrogen hormone epiestradiol. Involved in the glucuronidation of F2-isoprostane (5-epi-5-F2t-IsoP). Involved in the glucuronidation of the phytochemical ferulic acid at the carboxylic acid group. Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties. Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist caderastan, a drug which can inhibit the effect of angiotensin II. Involved in the biotransformation of 7-ethyl-10-hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan. Also metabolizes mycophenolate, an immunosuppressive agent., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 76, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B2RUL6;Q6XL45", "ec_number_list": [ { "id": "2.4.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.17", "type": "external" }, { "id": "2.4.1.170", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.170", "type": "external" }, { "id": "2.4.1.185", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.185", "type": "external" } ], "go_molecular_function": "GO:0008194 UDP-glycosyltransferase activity;GO:0004857 enzyme inhibitor activity;GO:0019899 enzyme binding;GO:0015020 glucuronosyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0008210 estrogen metabolic process;GO:0001889 liver development;GO:0016125 sterol metabolic process;GO:0071385 cellular response to glucocorticoid stimulus;GO:0051552 flavone metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6ZQM8-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6ZWZ2-1", "uniprot_id": [ { "id": "UB2R2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6ZWZ2", "type": "external" } ], "mass": 27166.0, "length": 238, "protein_name": "Ubiquitin-conjugating enzyme E2 R2", "gene_name": "Ube2r2", "organism": "Mouse", "refseq_name": "ubiquitin-conjugating enzyme E2 R2", "refseq_ac": [ { "id": "NP_080551", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080551", "type": "external" } ], "gene_names_uniprotkb": "Ube2r2; Cdc34b; Ubc3b", "gene_names_refseq": "1200003M11Rik; Cdc34b; Ubc3b; Ube2r2", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 R2; 2.3.2.23; E2 ubiquitin-conjugating enzyme R2; Ubiquitin carrier protein R2; Ubiquitin-conjugating enzyme E2-CDC34B; Ubiquitin-protein ligase R2", "protein_names_refseq": "E2 ubiquitin-conjugating enzyme R2; E2-CDC34B; ubiquitin carrier protein R2; ubiquitin-conjugating enzyme E2 R2; ubiquitin-conjugating enzyme E2-CDC34B; ubiquitin-protein ligase R2", "tax_id": 10090, "disease": "azoospermia (Disease Ontology:DOID:14227); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (mmu:67615); (R-MMU-8866652); (R-MMU-983168)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "12037680;34428180;40885482", "class_list": "", "function": "E2 ubiquitin-conjugating enzyme that accepts ubiquitin from an E1 ubiquitin-activating protein, and catalyzes its covalent attachment to other proteins by an E3 ubiquitin-protein ligase complex (By similarity). In vitro catalyzes monoubiquitination and 'Lys-48'-linked polyubiquitination (By similarity). Works in collaboration with various Cul1-RING and Cul2-RING E3 ligase complexes (By similarity). May be involved in degradation of katenin (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BW18;Q8VDE5", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "6.2.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.64", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004842 ubiquitin-protein transferase activity;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "", "go_biological_process": "GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0070936 protein K48-linked ubiquitination;GO:0006513 protein monoubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6ZWZ2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q715T0-1", "uniprot_id": [ { "id": "NDK8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q715T0", "type": "external" } ], "mass": 66857.0, "length": 586, "protein_name": "Protein NME8", "gene_name": "Nme8", "organism": "Mouse", "refseq_name": "protein NME8 isoform 2", "refseq_ac": [ { "id": "NP_001161381", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161381", "type": "external" } ], "gene_names_uniprotkb": "Nme8; Sptrx2; Txndc3", "gene_names_refseq": "1700056P15Rik; NDK8; Nme8; Sptrx-2; Txndc3", "protein_names_uniprotkb": "Protein NME8; 2.7.-.-; 3.1.11.-; NDK8; NME/NM23 family member 8; Nucleoside diphosphate kinase 8; Protein kinase NME8; Putative 3'-5'-DNA exonuclease NDK8; Spermatid-specific thioredoxin-2; Sptrx-2; Thioredoxin domain-containing protein 3", "protein_names_refseq": "3'-5' exonuclease NME8; nucleoside diphosphate kinase 8; protein NME8 isoform 2; protein NME8; protein kinase NME8; putative 3'-5'-DNA exonuclease NDK8; spermatid-specific thioredoxin-2; thioredoxin domain containing 3 (spermatozoa); thioredoxin domain-containing protein 3", "tax_id": 10090, "disease": "primary ciliary dyskinesia 6 (Disease Ontology:DOID:0110606)", "pathway": " (mmu:73412)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12909633;15781233;21750661;23707457;35820727", "class_list": "", "function": "Data indicate that spermatid-specific thioredoxin-2 incorporation into the sperm fibrous sheath(FS) lags well behind FS assembly, suggesting it is required during the final stages of sperm tail maturation, [RefSeq, PubMed]; Possesses an intrinsic kinase activity. In vitro, does not exhibit nucleoside diphosphate kinase (NDPK) activity or disulfide bond-reducing activity. Additionally, exhibits a 3'-5'-DNA exonuclease activity that removes single nucleotides from the 3' terminus of single-stranded DNA substrates and digests overhanging mismatched 3' termini from double-stranded DNA substrates, suggesting a role in DNA nucleolytic processing. May be required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Txndc2 and Txndc3 are critically important in protecting spermatozoa against the increases in oxidative stress associated with paternal age., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80W74", "ec_number_list": [], "go_molecular_function": "GO:0008296 3'-5'-DNA exonuclease activity;GO:0008017 microtubule binding;GO:0016740 transferase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0097598 sperm cytoplasmic droplet;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0030317 flagellated sperm motility;GO:0060271 cilium assembly;GO:0034614 cellular response to reactive oxygen species", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q715T0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80X89-1", "uniprot_id": [ { "id": "UD2A1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80X89", "type": "external" } ], "mass": 59965.0, "length": 528, "protein_name": "UDP-glucuronosyltransferase 2A1", "gene_name": "Ugt2a1", "organism": "Mouse", "refseq_name": "UDP-glucuronosyltransferase 2A1 precursor", "refseq_ac": [ { "id": "NP_444414", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444414", "type": "external" } ], "gene_names_uniprotkb": "Ugt2a1", "gene_names_refseq": "Ugt2a1", "protein_names_uniprotkb": "UDP-glucuronosyltransferase 2A1; 2.4.1.17; UDPGT 2A1; UGT2A1", "protein_names_refseq": "UDP glycosyltransferase 2 family, polypeptide A1; UDP-glucuronosyltransferase 2A1 precursor; UDP-glucuronosyltransferase 2A1; UDPGT 2A1; olfactory UDP glucuronosyltransferase", "tax_id": 10090, "disease": "", "pathway": " (mmu:94215); (R-MMU-156588); (R-MMU-9749641)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "11376859;34428180", "class_list": "glycogene;glycosyltransferase", "function": "UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (testosterones) and estrogens (estradiol and estriol). Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption. Shows a high affinity to aliphatic odorants such as citronellol as well as olfactory tissue specificity, and therefore may be involved in olfaction., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 17, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9ESE4", "ec_number_list": [ { "id": "2.4.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.17", "type": "external" }, { "id": "2.4.1.170", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.170", "type": "external" }, { "id": "2.4.1.185", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.185", "type": "external" } ], "go_molecular_function": "GO:0015020 glucuronosyltransferase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0008206 bile acid metabolic process;GO:0007608 sensory perception of smell;GO:0007606 sensory perception of chemical stimulus;GO:0009608 response to symbiont", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q80X89-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BG34-1", "uniprot_id": [ { "id": "UBX10_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BG34", "type": "external" } ], "mass": 30341.0, "length": 277, "protein_name": "UBX domain-containing protein 10", "gene_name": "Ubxn10", "organism": "Mouse", "refseq_name": "UBX domain-containing protein 10", "refseq_ac": [ { "id": "NP_001272857", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001272857", "type": "external" } ], "gene_names_uniprotkb": "Ubxn10; Ubxd3", "gene_names_refseq": "5730509E04Rik; A830047D02; Ubxd3; Ubxn10", "protein_names_uniprotkb": "UBX domain-containing protein 10; UBX domain-containing protein 3", "protein_names_refseq": "UBX domain containing 3; UBX domain-containing protein 10; UBX domain-containing protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:212190)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22872234", "class_list": "", "function": "VCP/p97-binding protein required for ciliogenesis. Acts as a tethering factor that facilitates recruitment of VCP/p97 to the intraflagellar transport complex B (IFT-B) in cilia. UBX domain-containing proteins act as tethering factors for VCP/p97 and may specify substrate specificity of VCP/p97., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TTR1;Q8BP58;Q8R0B6", "ec_number_list": [], "go_molecular_function": "GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005929 cilium;GO:0030992 intraciliary transport particle B", "go_biological_process": "GO:0060271 cilium assembly;GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BG34-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGR9-1", "uniprot_id": [ { "id": "UBCP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGR9", "type": "external" } ], "mass": 36837.0, "length": 318, "protein_name": "Ubiquitin-like domain-containing CTD phosphatase 1", "gene_name": "Ublcp1", "organism": "Mouse", "refseq_name": "ubiquitin-like domain-containing CTD phosphatase 1", "refseq_ac": [ { "id": "NP_077795", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077795", "type": "external" } ], "gene_names_uniprotkb": "Ublcp1", "gene_names_refseq": "4930527B16Rik; 8430435I17Rik; Ublcp1", "protein_names_uniprotkb": "Ubiquitin-like domain-containing CTD phosphatase 1; 3.1.3.16; Nuclear proteasome inhibitor UBLCP1", "protein_names_refseq": "nuclear proteasome inhibitor UBLCP1; ubiquitin-like domain-containing CTD phosphatase 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:79560)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "38129378", "class_list": "", "function": "A novel autism-associated UBLCP1 mutation impacts proteasome regulation/activity. Publication Status: Online-Only, [RefSeq, PubMed]; Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. Recruited to the 19S regulatory particle of the 26S proteasome through its interaction with 19S component PSMD2/RPN1. Once recruited, dephosphorylates 19S component PSMC2/RPT1 which impairs PSMC2 ATPase activity and disrupts 26S proteasome assembly. Has also been reported to stimulate the proteolytic activity of the 26S proteasome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ACX3;Q52L62;Q5XJH1;Q6PH96;Q99LT3", "ec_number_list": [ { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity;GO:1904855 proteasome regulatory particle binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0032780 negative regulation of ATP-dependent activity;GO:0090364 regulation of proteasome assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BGR9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BH48-1", "uniprot_id": [ { "id": "UBAP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BH48", "type": "external" } ], "mass": 55028.0, "length": 502, "protein_name": "Ubiquitin-associated protein 1", "gene_name": "Ubap1", "organism": "Mouse", "refseq_name": "ubiquitin-associated protein 1 isoform 2", "refseq_ac": [ { "id": "NP_001277383", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277383", "type": "external" } ], "gene_names_uniprotkb": "Ubap1", "gene_names_refseq": "2700092A01Rik; NAG20; UBAP-1; Ubap1; Ubap", "protein_names_uniprotkb": "Ubiquitin-associated protein 1; UBAP-1", "protein_names_refseq": "ubiquitin-associated protein 1 isoform 2", "tax_id": 10090, "disease": "hereditary spastic paraplegia 80 (Disease Ontology:DOID:0112341)", "pathway": " (mmu:67123); (R-MMU-917729)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "11599797;18299400;21750661;30084848;31203368;31515522;34428180;35962060", "class_list": "", "function": "Component of the ESCRT-I complex, a regulator of vesicular trafficking process (PubMed:31203368). Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) (By similarity). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2 (PubMed:31203368)., [UniProtKB, UniProtKB, PubMed]; Exome sequencing of genomic DNA from patients in four families was carried out, followed by Sanger sequencing of the UBAP1 gene. A mouse homolog of one UBAP1 frameshift mutation carried by one of the patients was created as a disease model. Functional properties of the UBAP1 wild type and UBAP1-mutant in mouse hippocampus neurons were examined., [RefSeq, PubMed]; Ubap1 knock-in mice reproduced the phenotype of SPG80., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BQ80;Q8BSW6;Q9D749;Q9ERV5", "ec_number_list": [], "go_molecular_function": "GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0000813 ESCRT I complex", "go_biological_process": "GO:0015031 protein transport;GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BH48-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BQH4-1", "uniprot_id": [ { "id": "UBAD2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BQH4", "type": "external" } ], "mass": 17671.0, "length": 164, "protein_name": "UBA-like domain-containing protein 2", "gene_name": "Ubald2", "organism": "Mouse", "refseq_name": "UBA-like domain-containing protein 2", "refseq_ac": [ { "id": "NP_795876", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_795876", "type": "external" } ], "gene_names_uniprotkb": "Ubald2; Fam100b", "gene_names_refseq": "1110014K08Rik; D030012E24Rik; Fam100b; Ubald2", "protein_names_uniprotkb": "UBA-like domain-containing protein 2", "protein_names_refseq": "UBA-like domain-containing protein 2; family with sequence similarity 100, member B; protein FAM100B", "tax_id": 10090, "disease": "", "pathway": " (mmu:319370)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AAP1;Q3UMH5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8BQH4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BU04-1", "uniprot_id": [ { "id": "UBR7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BU04", "type": "external" } ], "mass": 48065.0, "length": 425, "protein_name": "Putative E3 ubiquitin-protein ligase UBR7", "gene_name": "Ubr7", "organism": "Mouse", "refseq_name": "putative E3 ubiquitin-protein ligase UBR7", "refseq_ac": [ { "id": "NP_079942", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079942", "type": "external" } ], "gene_names_uniprotkb": "Ubr7", "gene_names_refseq": "5730410I19Rik; Ubr7", "protein_names_uniprotkb": "Putative E3 ubiquitin-protein ligase UBR7; 2.3.2.27; N-recognin-7; RING-type E3 ubiquitin transferase UBR7", "protein_names_refseq": "N-recognin-7; RING-type E3 ubiquitin transferase UBR7; putative E3 ubiquitin-protein ligase UBR7", "tax_id": 10090, "disease": "", "pathway": " (mmu:66622)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16055722;24664117;31219806;34428180", "class_list": "", "function": "E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation., [UniProtKB]; These data provide the first evidence of ubiquitin ligase activity in mammalian spermatozoa and indicate UBR7 involvement in spermiogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80UT9", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "", "go_biological_process": "GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BU04-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BY87-1", "uniprot_id": [ { "id": "UBP47_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BY87", "type": "external" } ], "mass": 157455.0, "length": 1376, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 47", "gene_name": "Usp47", "organism": "Mouse", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 47 isoform 2", "refseq_ac": [ { "id": "NP_598519", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598519", "type": "external" } ], "gene_names_uniprotkb": "Usp47", "gene_names_refseq": "4930502N04Rik; A630020C16Rik; Usp47", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 47; 3.4.19.12; Deubiquitinating enzyme 47; Ubiquitin thioesterase 47; Ubiquitin-specific-processing protease 47", "protein_names_refseq": "deubiquitinating enzyme 47; ubiquitin carboxyl-terminal hydrolase 47 isoform 2; ubiquitin carboxyl-terminal hydrolase 47; ubiquitin specific protease 47; ubiquitin thioesterase 47; ubiquitin thiolesterase 47; ubiquitin-specific-processing protease 47", "tax_id": 10090, "disease": "", "pathway": " (mmu:74996); (R-MMU-5689880)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;15345747;17242355;19966869;21183079;21750661;22872234;25605945;30084848;30779550;31219806;31599954;34428180;37487274;37507081;37924851;38832955;39627609", "class_list": "", "function": "USP47 deficiency in mice modulates tumor infiltrating immune cells and enhances antitumor immune responses in prostate cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Ubiquitin specific peptidase 47 contributes to liver regeneration., [RefSeq, PubMed]; Ubiquitin-specific peptidase 47 (USP47) regulates cutaneous oxidative injury through nicotinamide nucleotide transhydrogenase (NNT)., [RefSeq, PubMed]; Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER) (By similarity). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q32NY0;Q5EBP2;Q6KAR9;Q80V06;Q8BHU1;Q8BI15;Q8BI16;Q8BUW4;Q91X25", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" } ], "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity;GO:0101005 deubiquitinase activity;GO:0071987 WD40-repeat domain binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0006508 proteolysis;GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage;GO:0006284 base-excision repair;GO:0006974 DNA damage response;GO:0031647 regulation of protein stability", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q8BY87-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BYR1-1", "uniprot_id": [ { "id": "TYW4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BYR1", "type": "external" } ], "mass": 75295.0, "length": 686, "protein_name": "tRNA wybutosine-synthesizing protein 4", "gene_name": "Lcmt2", "organism": "Mouse", "refseq_name": "tRNA wybutosine-synthesizing protein 4", "refseq_ac": [ { "id": "NP_808514", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808514", "type": "external" } ], "gene_names_uniprotkb": "Lcmt2; Kiaa0547; Tyw4", "gene_names_refseq": "D330024M17; Lcmt2; Tyw4", "protein_names_uniprotkb": "tRNA wybutosine-synthesizing protein 4; 2.1.1.290; 2.3.1.231; Leucine carboxyl methyltransferase 2; p21WAF1/CIP1 promoter-interacting protein; tRNA yW-synthesizing protein 4; tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase; tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase", "protein_names_refseq": "p21WAF1/CIP1 promoter-interacting protein; tRNA wybutosine-synthesizing protein 4 homolog; tRNA wybutosine-synthesizing protein 4; tRNA yW-synthesizing protein 4 homolog; tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)- methoxycarbonyltransferase; tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)- methyltransferase", "tax_id": 10090, "disease": "", "pathway": " (mmu:329504)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25428506;31219806", "class_list": "", "function": "S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the final 2 independent reactions, methylation of the alpha-carboxy group of wybutosine-72 to form wybutosine-58, and methoxycarbonylation of alpha-amino group of wybutosine-58 through the fixation of CO(2) to complete wybutosine., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ART9;Q3T9F7;Q6A048;Q8BIG6", "ec_number_list": [ { "id": "2.1.1.290", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.290", "type": "external" }, { "id": "2.3.1.231", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.231", "type": "external" } ], "go_molecular_function": "GO:0008175 tRNA methyltransferase activity;GO:0003880 protein C-terminal carboxyl O-methyltransferase activity", "go_cellular_component": "", "go_biological_process": "GO:0030488 tRNA methylation;GO:0006481 C-terminal protein methylation;GO:0031591 wybutosine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BYR1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C878-1", "uniprot_id": [ { "id": "UBA3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C878", "type": "external" } ], "mass": 51737.0, "length": 462, "protein_name": "NEDD8-activating enzyme E1 catalytic subunit", "gene_name": "Uba3", "organism": "Mouse", "refseq_name": "NEDD8-activating enzyme E1 catalytic subunit isoform 2", "refseq_ac": [ { "id": "NP_001104576", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104576", "type": "external" } ], "gene_names_uniprotkb": "Uba3; Ube1c", "gene_names_refseq": "A830034N06Rik; Uba3; Ube1c", "protein_names_uniprotkb": "NEDD8-activating enzyme E1 catalytic subunit; 6.2.1.64; NEDD8-activating enzyme E1C; Ubiquitin-activating enzyme 3; Ubiquitin-activating enzyme E1C; Ubiquitin-like modifier-activating enzyme 3", "protein_names_refseq": "NEDD8-activating enzyme E1 catalytic subunit isoform 2; NEDD8-activating enzyme E1 catalytic subunit; NEDD8-activating enzyme E1C; ubiquitin-activating enzyme 3; ubiquitin-activating enzyme E1C", "tax_id": 10090, "disease": "", "pathway": " (mmu:22200); (R-MMU-5607761); (R-MMU-5676590); (R-MMU-983168)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;10207026;11696557;20937703;21750661;25428506;28135057;30084848;30779550;31219806;34203471;34428180", "class_list": "", "function": "Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression., [UniProtKB, PubMed]; The protein encoded by this gene is the catalytic subunit of the enzyme that activates NEDD8, a ubiquitin-like molecule that binds to its target proteins through an enzymatic reaction analagous to ubiquitylation. Embryonic mice deficient for this protein die prior to implantation and display apoptosis of the inner cell mass. Trophoblastic cells cannot enter S phase, demonstrating that this gene is required for cell cycle progression during embryogenesis. Two pseudogenes have been found for this gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O88598;Q3TG68;Q9D6B7", "ec_number_list": [ { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "6.2.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.64", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity;GO:0044877 protein-containing complex binding;GO:0016922 nuclear receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0032991 protein-containing complex", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0045892 negative regulation of DNA-templated transcription;GO:0045116 protein neddylation;GO:0051726 regulation of cell cycle;GO:0007113 endomitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8C878-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CBR6-1", "uniprot_id": [ { "id": "TSK_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CBR6", "type": "external" } ], "mass": 38362.0, "length": 354, "protein_name": "Tsukushi", "gene_name": "Tsku", "organism": "Mouse", "refseq_name": "tsukushi precursor", "refseq_ac": [ { "id": "NP_001019790", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019790", "type": "external" } ], "gene_names_uniprotkb": "Tsku; Lrrc54; Tsk", "gene_names_refseq": "9530051K01Rik; E2ig4; Lrrc54; Tsku; Tsk", "protein_names_uniprotkb": "Tsukushi; Leucine-rich repeat-containing protein 54", "protein_names_refseq": "leucine rich repeat containing 54; leucine-rich repeat-containing protein 54; tsukushi precursor; tsukushin", "tax_id": 10090, "disease": "", "pathway": " (mmu:244152)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "17322886;21055390;21856951;22995554;23206892;25159578;30232710;30271858;30595550;31391339;31535079;31767170;31983064;32127020;33790026;34183373;35025761", "class_list": "", "function": "A crucial role for TSK for anterior commissure formation in the mouse brain was shown., [RefSeq, PubMed]; Contributes to various developmental events and other processes such as wound healing and cholesterol homeostasis through its interactions with multiple signaling pathways (PubMed:21856951, PubMed:22995554, PubMed:25159578, PubMed:31391339). Wnt signaling inhibitor which competes with WNT2B for binding to Wnt receptor FZD4 and represses WNT2B-dependent development of the peripheral eye (PubMed:21856951). Plays a role in regulating the hair cycle by controlling TGFB1 signaling (PubMed:22995554). Required for the development of the anterior commissure in the brain by inhibiting neurite outgrowth (PubMed:21055390, PubMed:23206892). Essential for terminal differentiation of hippocampal neural stem cells (PubMed:31983064). Plays a role in regulating bone elongation and bone mass by modulating growth plate chondrocyte function and overall body size (PubMed:30271858). Required for development of the inner ear through its involvement in stereocilia formation in inner hair cells (PubMed:32127020). Facilitates wound healing by inhibiting secretion of TGFB1 from macrophages which prevents myofibroblast differentiation, maintaining inflammatory cell quiescence (PubMed:25159578). Plays a role in cholesterol homeostasis by reducing circulating high-density lipoprotein cholesterol, lowering cholesterol efflux capacity and decreasing cholesterol-to-bile acid conversion in the liver (PubMed:31391339). In one study, shown to negatively regulate sympathetic innervation in brown fat, leading to reduced energy expenditure (PubMed:31535079). In another study, shown not to affect brown fat thermogenic capacity, body weight gain or glucose homeostasis (PubMed:31767170)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Deletion of the Feeding-Induced Hepatokine TSK Ameliorates the Melanocortin Obesity Syndrome., [RefSeq, PubMed]; Dysfunction of the proteoglycan Tsukushi causes hydrocephalus through altered neurogenesis in the subventricular zone in mice., [RefSeq, PubMed]; TSK controls the hair cycle by regulating TGF-beta1 signaling., [RefSeq, PubMed]; Targeted inactivation of the TSK gene in mice causes expansion of the ciliary body and up-regulation of Wnt2b and Fzd4 expression in the developing peripheral eye, [RefSeq, PubMed]; The hepatokine TSK maintains myofiber integrity and exercise endurance and contributes to muscle regeneration. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q4W655", "ec_number_list": [], "go_molecular_function": "GO:0050431 transforming growth factor beta binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0140150 gel phase of interstitial matrix", "go_biological_process": "GO:1904761 negative regulation of myofibroblast differentiation;GO:0008203 cholesterol metabolic process;GO:0021766 hippocampus development;GO:0097009 energy homeostasis;GO:0010977 negative regulation of neuron projection development", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q8CBR6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CDN6-1", "uniprot_id": [ { "id": "TXNL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CDN6", "type": "external" } ], "mass": 32237.0, "length": 289, "protein_name": "Thioredoxin-like protein 1", "gene_name": "Txnl1", "organism": "Mouse", "refseq_name": "thioredoxin-like protein 1", "refseq_ac": [ { "id": "NP_058072", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058072", "type": "external" } ], "gene_names_uniprotkb": "Txnl1; Trp32; Txnl", "gene_names_refseq": "32kDa; TRP32; Txnl1; Txnl", "protein_names_uniprotkb": "Thioredoxin-like protein 1; 32 kDa thioredoxin-related protein", "protein_names_refseq": "32 kDa thioredoxin-related protein; thioredoxin-like (32kD); thioredoxin-like protein 1; thioredoxin-related protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:53382); (R-MMU-9013418); (R-MMU-9013420); (R-MMU-9013422); (R-MMU-9013424); (R-MMU-9696264); (R-MMU-9696270); (R-MMU-9696273)", "pathway_count": 8, "publication_count": 14, "publication_id_list": "18299400;19349280;20173027;21750661;23386199;24788674;25428506;25605945;26495903;30084848;34428180;35820727;37507081;9668102", "class_list": "", "function": "Active thioredoxin with a redox potential of about -250 mV., [UniProtKB, UniProtKB, UniProtKB]; TRP32 was identified as a novel subunit of the 26 S proteasome. Erratum:[J Biol Chem. 2020 Jul 3;295(27):9267. doi: 10.1074/jbc.AAC120.014712. PMID: 32620695], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O70379;Q3TI92", "ec_number_list": [], "go_molecular_function": "GO:0015036 disulfide oxidoreductase activity;GO:0015035 protein-disulfide reductase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000502 proteasome complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8CDN6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CGR7-1", "uniprot_id": [ { "id": "UPP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CGR7", "type": "external" } ], "mass": 35755.0, "length": 320, "protein_name": "Uridine phosphorylase 2", "gene_name": "Upp2", "organism": "Mouse", "refseq_name": "uridine phosphorylase 2 isoform 3", "refseq_ac": [ { "id": "NP_083968", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083968", "type": "external" } ], "gene_names_uniprotkb": "Upp2", "gene_names_refseq": "1700124F02Rik; UDRPASE2; UP2; UPASE2; Upp2", "protein_names_uniprotkb": "Uridine phosphorylase 2; 2.4.2.3; L-UrdPase; Liver-specific uridine phosphorylase; UPase 2; UrdPase 2", "protein_names_refseq": "L-UrdPase; liver-specific uridine phosphorylase; uridine phosphorylase 2 isoform 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:76654); (R-MMU-73614); (R-MMU-73621)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "14715930;21750661;34428180;38183795", "class_list": "", "function": "Catalyzes the reversible phosphorylytic cleavage of uridine to uracil and ribose-1-phosphate which can then be utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Shows broad substrate specificity and can also accept deoxyuridine and other analogous compounds., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; Identification of BMAL1-Regulated circadian genes in mouse liver and their potential association with hepatocellular carcinoma: Gys2 and Upp2 as promising candidates., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.3", "type": "external" } ], "go_molecular_function": "GO:0004850 uridine phosphorylase activity;GO:0042802 identical protein binding;GO:0009032 thymidine phosphorylase activity;GO:0047847 deoxyuridine phosphorylase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0045098 type III intermediate filament;GO:0005737 cytoplasm", "go_biological_process": "GO:0046079 dUMP catabolic process;GO:0006218 uridine catabolic process;GO:0044206 UMP salvage;GO:0042178 xenobiotic catabolic process;GO:0006248 CMP catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8CGR7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K2Z8-1", "uniprot_id": [ { "id": "UB2Q2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K2Z8", "type": "external" } ], "mass": 42935.0, "length": 378, "protein_name": "Ubiquitin-conjugating enzyme E2 Q2", "gene_name": "Ube2q2", "organism": "Mouse", "refseq_name": "ubiquitin-conjugating enzyme E2 Q2 isoform 3", "refseq_ac": [ { "id": "NP_001333587", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333587", "type": "external" } ], "gene_names_uniprotkb": "Ube2q2", "gene_names_refseq": "3010021M21Rik; Ube2q2", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 Q2; 2.3.2.23; E2 ubiquitin-conjugating enzyme Q2; Ubiquitin carrier protein Q2; Ubiquitin-protein ligase Q2", "protein_names_refseq": "E2 ubiquitin-conjugating enzyme Q2; ubiquitin carrier protein Q2; ubiquitin-conjugating enzyme E2 Q2 isoform 3; ubiquitin-conjugating enzyme E2 Q2; ubiquitin-conjugating enzyme E2Q (putative) 2; ubiquitin-protein ligase Q2", "tax_id": 10090, "disease": "", "pathway": " (mmu:109161); (R-MMU-8866652); (R-MMU-983168)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "21750661;22872234;31219806;35199132", "class_list": "", "function": "Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; [Ubiquitin-conjugating enzyme UBE2Q2 participates in HUWE1-mediated protection on renal tubulointerstitial fibrosis]., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UBX3;Q3V3A5;Q8BUN2;Q8BVX5", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "6.2.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.64", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004842 ubiquitin-protein transferase activity;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0070936 protein K48-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8K2Z8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VBW8-1", "uniprot_id": [ { "id": "TTC36_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VBW8", "type": "external" } ], "mass": 20132.0, "length": 186, "protein_name": "Tetratricopeptide repeat protein 36", "gene_name": "Ttc36", "organism": "Mouse", "refseq_name": "tetratricopeptide repeat protein 36", "refseq_ac": [ { "id": "NP_620401", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620401", "type": "external" } ], "gene_names_uniprotkb": "Ttc36", "gene_names_refseq": "Ttc36", "protein_names_uniprotkb": "Tetratricopeptide repeat protein 36; TPR repeat protein 36", "protein_names_refseq": "TPR repeat protein 36; tetratricopeptide repeat protein 36", "tax_id": 10090, "disease": "", "pathway": " (mmu:192653)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "27826126;34428180", "class_list": "", "function": "Collectively, on the basis of the expression pattern, Ttc36 is specifically expressed in proximal distal tubules, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0007613 memory;GO:0008542 visual learning;GO:0021954 central nervous system neuron development;GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0010801 negative regulation of peptidyl-threonine phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8VBW8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91WB7-1", "uniprot_id": [ { "id": "UBTD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91WB7", "type": "external" } ], "mass": 25985.0, "length": 227, "protein_name": "Ubiquitin domain-containing protein 1", "gene_name": "Ubtd1", "organism": "Mouse", "refseq_name": "ubiquitin domain-containing protein 1", "refseq_ac": [ { "id": "NP_663475", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663475", "type": "external" } ], "gene_names_uniprotkb": "Ubtd1", "gene_names_refseq": "Ubtd1", "protein_names_uniprotkb": "Ubiquitin domain-containing protein 1", "protein_names_refseq": "ubiquitin domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:226122)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in the regulation of cellular senescence through a positive feedback loop with TP53. Is a TP53 downstream target gene that increases the stability of TP53 protein by promoting the ubiquitination and degradation of MDM2., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q91WB7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q924A4-1", "uniprot_id": [ { "id": "UCN3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q924A4", "type": "external" } ], "mass": 18063.0, "length": 164, "protein_name": "Urocortin-3", "gene_name": "Ucn3", "organism": "Mouse", "refseq_name": "urocortin-3 preproprotein", "refseq_ac": [ { "id": "NP_112540", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112540", "type": "external" } ], "gene_names_uniprotkb": "Ucn3", "gene_names_refseq": "Ucn3; ucn III", "protein_names_uniprotkb": "Urocortin-3; Ucn III; Urocortin III", "protein_names_refseq": "Urocortin III; urocortin-3 preproprotein", "tax_id": 10090, "disease": "", "pathway": " (mmu:83428); (R-MMU-373080)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "11416224;12810578;12970163;15117334;17360501;20404164;20937857;22371083;32928873;34423776;38593829", "class_list": "", "function": "CRFR2beta selective Ucn-II or Ucn-III will protect cardiomyocytes and the ex vivo Langendorff perfused rat heart from ischemia reperfusion injury by activation of ERK1/2-p42, 44., [RefSeq, PubMed]; Hormone that plays a central role in whole body adaptation to stress (PubMed:17360501, PubMed:20404164, PubMed:20937857). Released by the hypothalamus primarily in response to physical or psychological stress and acts by binding to CRH receptor CRHR2 (PubMed:17360501). UCN3-dependent signaling plays a key role in the metabolic regulation and energy homeostasis in responses to stress, acting as an anxiolytic (PubMed:17360501, PubMed:20404164). Promotes energy balance by reducing food intake, improving insulin sensitivity and managing blood glucose levels in response to metabolic stress (PubMed:17360501, PubMed:20404164). In contrast to CRH and UCN, does not activate the hypothalamus-pituitary-adrenal axis to promote corticotropin hormone (ACTH) production (By similarity). UCN3-dependent signaling also acts as a regulator of aggressive behavior (PubMed:34423776)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Mouse Urocortin III is expressed in brain regions involved in stress-related behaviours, and its expression in the hypothalamus increases following restraint. Administration of mUcnIII stimulates reduced anxiety., [RefSeq, PubMed]; Pancreatic Ucn III acting through CRFR2 is involved in the local regulation of glucagon and insulin secretion., [RefSeq, PubMed]; This gene encodes a member of the corticotropin-releasing hormone peptide family that participates in coordinating autonomic, endocrine, and behavioral responses to stress. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional hormone. The pancreatic islets isolated from mice lacking the encoded protein secrete less insulin in response to high glucose concentrations. Transgenic mice overexpressing the encoded protein exhibit a metabolically favorable phenotype resisting obesity and hyperglycemia on a high-fat diet. [provided by RefSeq, Sep 2016]., [RefSeq]; Urocortin 3 contributes to paracrine inhibition of islet alpha cells in mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051429 corticotropin-releasing hormone receptor binding;GO:0005184 neuropeptide hormone activity;GO:0051431 corticotropin-releasing hormone receptor 2 binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0030424 axon;GO:0043679 axon terminus;GO:0043196 varicosity", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0032024 positive regulation of insulin secretion;GO:0042594 response to starvation;GO:0071456 cellular response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q924A4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99ML8-1", "uniprot_id": [ { "id": "UCN2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99ML8", "type": "external" } ], "mass": 12310.0, "length": 113, "protein_name": "Urocortin-2", "gene_name": "Ucn2", "organism": "Mouse", "refseq_name": "urocortin-2 preproprotein", "refseq_ac": [ { "id": "NP_659543", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659543", "type": "external" } ], "gene_names_uniprotkb": "Ucn2", "gene_names_refseq": "Ucn II; Ucn-2; Ucn2; ucn-II", "protein_names_uniprotkb": "Urocortin-2; Ucn II; Urocortin II", "protein_names_refseq": "Urocortin II; urocortin-2 preproprotein", "tax_id": 10090, "disease": "colitis (Disease Ontology:DOID:0060180); hypertension (Disease Ontology:DOID:10763); atherosclerosis (Disease Ontology:DOID:1936); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (mmu:171530); (R-MMU-373080)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "11226328;12764078;12970163;17050686;18308934;20937857;23493376;24043794;28851616;35390501;37402735;38081372", "class_list": "", "function": "CRFR2beta selective Ucn-II or Ucn-III will protect cardiomyocytes and the ex vivo Langendorff perfused rat heart from ischemia reperfusion injury by activation of ERK1/2-p42, 44., [RefSeq, PubMed]; Chronic UCN2 treatment desensitizes CRHR2 and improves insulin sensitivity. Publication Status: Online-Only, [RefSeq, PubMed]; Description of ucn2 posttranslational processing and peptide sequence. Hypoxia and glycosylation, paradigms that might influence secretion or processing of gene products, did not significantly impact hUcn 2 prohormone cleavage., [RefSeq, PubMed]; Hormone that plays a central role in whole body adaptation to stress. Released by the hypothalamus primarily in response to physical or psychological stress and acts by binding to CRH receptor CRHR2 (PubMed:17050686, PubMed:18308934, PubMed:20937857, PubMed:24043794). UCN2-dependent signaling regulates cardiovascular function, promotes skeletal muscle hypertrophy and manage energy balance and acts as an anorexigenic agent (PubMed:17050686). In contrast to CRH and UCN, does not activate the hypothalamus-pituitary-adrenal axis to promote corticotropin hormone (ACTH) production (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; This gene encodes a member of the corticotropin-releasing hormone peptide family that participates in coordinating autonomic, endocrine, and behavioral responses to stress. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional hormone. Mice lacking the encoded protein exhibit increased insulin sensitivity and were protected against fat-induced insulin resistance. In addition, female mice lacking the encoded protein exhibit a significant increase in the basal daily rhythms of adrenocorticotropic hormone and corticosterone, and a significant decrease in fluid intake and depressive-like behavior. [provided by RefSeq, Sep 2016]., [RefSeq]; Ucn II is expressed in the hypothalamus, brainstem, olfactory bulb, and pituitary. Low levels were also detected in the mouse cortex, hippocampus, and spinal cord, Ucn II gene transcription was stimulated by glucocorticoids, [RefSeq, PubMed]; Urocortin 2 acts on gonadotrophs expressing the corticotropin-releasing factor type 2 receptor, and inhibits the production of gonadotropins in the pituitary gonadotropic tumor cells., [RefSeq, PubMed]; Urocortin 2 promotes hypertrophy and enhances skeletal muscle function through cAMP and insulin/IGF-1 signaling pathways., [RefSeq, PubMed]; Urocortin2 attenuates diabetic coronary microvascular dysfunction by regulating macrophage extracellular vesicles., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F8WIL4", "ec_number_list": [], "go_molecular_function": "GO:0051429 corticotropin-releasing hormone receptor binding;GO:0001664 G protein-coupled receptor binding;GO:0042562 hormone binding;GO:0005179 hormone activity;GO:0051431 corticotropin-releasing hormone receptor 2 binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0046882 negative regulation of follicle-stimulating hormone secretion;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0010629 negative regulation of gene expression;GO:0009755 hormone-mediated signaling pathway;GO:0007586 digestion", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q99ML8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99MX1-1", "uniprot_id": [ { "id": "UBP26_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99MX1", "type": "external" } ], "mass": 95452.0, "length": 835, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 26", "gene_name": "Usp26", "organism": "Mouse", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 26", "refseq_ac": [ { "id": "NP_113565", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113565", "type": "external" } ], "gene_names_uniprotkb": "Usp26", "gene_names_refseq": "Usp26", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 26; 3.4.19.12; Deubiquitinating enzyme 26; Ubiquitin thioesterase 26; Ubiquitin-specific-processing protease 26", "protein_names_refseq": "deubiquitinating enzyme 26; ubiquitin carboxyl-terminal hydrolase 26; ubiquitin specific protease 26; ubiquitin thioesterase 26; ubiquitin thiolesterase 26; ubiquitin-specific-processing protease 26", "tax_id": 10090, "disease": "X-linked spermatogenic failure 6 (Disease Ontology:DOID:0070597)", "pathway": " (mmu:83563); (R-MMU-5689880)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;11279525;16118233;21449984;28839133;30016717;31599954;35091692;35820727;35857630;39251623", "class_list": "", "function": "An RNF12-USP26 amplification loop drives germ cell specification and is disrupted by disease-associated mutations., [RefSeq, PubMed]; Deubiquitinase regulating several biological processes through the deubiquitination of components of these processes (PubMed:28839133). Involved in somatic cell reprogramming through the 'Lys-48'-linked deubiquitination and stabilization of CBX4 and CBX6, two components of the polycomb-repressive complex 1 (PRC1) (By similarity). Also deubiquitinates and probably stabilizes the androgen receptor (AR), regulating the androgen receptor signaling pathway (By similarity). May play a role in spermatogenesis (By similarity)., [UniProtKB, UniProtKB, PubMed]; Germ-cell-specific sex-linked genes, like Usp26, are subject to meiotic sex-chromosome inactivation (MSCI) during spermatogenesis., [RefSeq, PubMed]; RT-PCR assays detected the expression of Usp26 in germ cells, but not in primary Sertoli cell lines, [RefSeq, PubMed]; The osteoprotective role of USP26 in coordinating bone formation and resorption., [RefSeq, PubMed]; USP26 as a hepatitis B virus-induced deubiquitinase primes hepatocellular carcinogenesis by epigenetic remodeling. Publication Status: Online-Only, [RefSeq, PubMed]; Usp26 is a testis-specific gene identified in a genome-wide cDNA subtraction screen., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q05A11", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity;GO:1990380 K48-linked deubiquitinase activity;GO:0101005 deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0036126 sperm flagellum", "go_biological_process": "GO:0006508 proteolysis;GO:0007283 spermatogenesis;GO:0016579 protein deubiquitination;GO:0031647 regulation of protein stability;GO:0000082 G1/S transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q99MX1-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99N42-1", "uniprot_id": [ { "id": "TYPH_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99N42", "type": "external" } ], "mass": 49336.0, "length": 471, "protein_name": "Thymidine phosphorylase", "gene_name": "Tymp", "organism": "Mouse", "refseq_name": "thymidine phosphorylase", "refseq_ac": [ { "id": "NP_612175", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612175", "type": "external" } ], "gene_names_uniprotkb": "Tymp; Ecgf1", "gene_names_refseq": "2900072D10Rik; Ecgf1; PD-ECGF; PDECGF; Pdgfec; TP; Tymp", "protein_names_uniprotkb": "Thymidine phosphorylase; 2.4.2.4; TP; TdRPase", "protein_names_refseq": "endothelial cell growth factor 1 (platelet-derived); gliostatin; platelet derived growth factor, endothelial cell; tdRPase; thymidine phosphorylase", "tax_id": 10090, "disease": "ductal carcinoma in situ (Disease Ontology:DOID:0060074); mitochondrial DNA depletion syndrome 1 (Disease Ontology:DOID:0080119); urinary bladder cancer (Disease Ontology:DOID:11054); endometrial cancer (Disease Ontology:DOID:1380); pancreatic cancer (Disease Ontology:DOID:1793); ovarian cancer (Disease Ontology:DOID:2394); transitional cell carcinoma (Disease Ontology:DOID:2671); teratoma (Disease Ontology:DOID:3307); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); cervical squamous cell carcinoma (Disease Ontology:DOID:3744); lung non-small cell carcinoma (Disease Ontology:DOID:3908); seminoma (Disease Ontology:DOID:4440); renal cell carcinoma (Disease Ontology:DOID:4450); common bile duct neoplasm (Disease Ontology:DOID:4608); gallbladder carcinoma (Disease Ontology:DOID:4948); mitochondrial encephalomyopathy (Disease Ontology:DOID:890)", "pathway": " (mmu:72962); (R-MMU-73614); (R-MMU-73621)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "32476180", "class_list": "", "function": "Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity)., [UniProtKB]; Thymidine phosphorylase promotes angiogenesis and tumour growth in intrahepatic cholangiocarcinoma., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.4", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0004645 1,4-alpha-oligoglucan phosphorylase activity;GO:0009032 thymidine phosphorylase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:1905333 regulation of gastric motility;GO:0006935 chemotaxis;GO:0009887 animal organ morphogenesis;GO:0006213 pyrimidine nucleoside metabolic process;GO:0031641 regulation of myelination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q99N42-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQM5-1", "uniprot_id": [ { "id": "TXD17_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQM5", "type": "external" } ], "mass": 14015.0, "length": 123, "protein_name": "Thioredoxin domain-containing protein 17", "gene_name": "Txndc17", "organism": "Mouse", "refseq_name": "thioredoxin domain-containing protein 17", "refseq_ac": [ { "id": "NP_080835", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080835", "type": "external" } ], "gene_names_uniprotkb": "Txndc17; Txnl5", "gene_names_refseq": "4831443O22Rik; D11Ertd672e; TRP14; Txndc17; Txnl5", "protein_names_uniprotkb": "Thioredoxin domain-containing protein 17; 14 kDa thioredoxin-related protein; Protein 42-9-9; TRP14; Thioredoxin-like protein 5", "protein_names_refseq": "14 kDa thioredoxin-related protein; protein 42-9-9; putative 42-9-9 protein; thioredoxin domain-containing protein 17; thioredoxin-like 5; thioredoxin-like protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:52700)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17007870;25002534;31911946;37453647;37507081;37828378;38811853", "class_list": "", "function": "Control of protein function through oxidation and reduction of persulfidated states. Publication Status: Online-Only, [RefSeq, PubMed]; Disulfide reductase. May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Modulates TNF signaling and NF-kappa-B activation. Has peroxidase activity and may contribute to the elimination of cellular hydrogen peroxide (By similarity)., [UniProtKB]; In this review, we will summarize the cardiac effects of thioredoxin and the mechanisms by which thioredoxin mediates inhibition of ventricular remodeling. Review article, [RefSeq, PubMed]; Results suggest that TRP14 regulates osteoclasts differentiation and bone resorption through its catalytic activity and that enhancing TRP14 may present a new strategy for preventing bone resorption diseases., [RefSeq, PubMed]; TRP14 is the rate-limiting enzyme for intracellular cystine reduction and regulates proteome cysteinylation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TE14;Q921A9;Q9D0Y4", "ec_number_list": [], "go_molecular_function": "GO:0004601 peroxidase activity;GO:0047134 protein-disulfide reductase [NAD(P)H] activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0033209 tumor necrosis factor-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9CQM5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQU0-1", "uniprot_id": [ { "id": "TXD12_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQU0", "type": "external" } ], "mass": 19049.0, "length": 170, "protein_name": "Thioredoxin domain-containing protein 12", "gene_name": "Txndc12", "organism": "Mouse", "refseq_name": "thioredoxin domain-containing protein 12 precursor", "refseq_ac": [ { "id": "NP_079610", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079610", "type": "external" } ], "gene_names_uniprotkb": "Txndc12; Tlp19", "gene_names_refseq": "0610040B21Rik; ERp16; ERp19; Txndc12", "protein_names_uniprotkb": "Thioredoxin domain-containing protein 12; 1.8.4.2; ER protein 19; ERp19; Endoplasmic reticulum resident protein 19; Thioredoxin-like protein p19", "protein_names_refseq": "ER protein 19; endoplasmic reticulum protein ERp19; endoplasmic reticulum resident protein 19; ortholog of endoplasmic reticulum thioredoxin superfamily member, 18 kDa TLP19; thioredoxin domain-containing protein 12 precursor; thioredoxin domain-containing protein 12; thioredoxin-like protein p19", "tax_id": 10090, "disease": "", "pathway": " (mmu:66073)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;12930873;18628206;22517741;26740625;30059200;30899004", "class_list": "", "function": "Both ERp19 and ERp46 and their respective mRNAs are highly expressed in the liver as compared with other tissues, [RefSeq, PubMed]; ERp16 mediates disulfide bond formation in the ER and plays an important role in cellular defense against prolonged ER stress, [RefSeq, PubMed]; Protein-disulfide reductase of the endoplasmic reticulum that promotes disulfide bond formation in client proteins through its thiol-disulfide oxidase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q53YN1", "ec_number_list": [ { "id": "1.8.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.2", "type": "external" } ], "go_molecular_function": "GO:0019153 protein-disulfide reductase (glutathione) activity;GO:0015035 protein-disulfide reductase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9CQU0-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CZY3-1", "uniprot_id": [ { "id": "UB2V1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CZY3", "type": "external" } ], "mass": 16355.0, "length": 147, "protein_name": "Ubiquitin-conjugating enzyme E2 variant 1", "gene_name": "Ube2v1", "organism": "Mouse", "refseq_name": "ubiquitin-conjugating enzyme E2 variant 1 isoform 3", "refseq_ac": [ { "id": "NP_001298075", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001298075", "type": "external" } ], "gene_names_uniprotkb": "Ube2v1; Croc1", "gene_names_refseq": "0610011J09Rik; CROC-1; CROC1; D7Bwg1382e; UEV-1; Ube2v1", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 variant 1; CROC-1; UEV-1", "protein_names_refseq": "ubiquitin-conjugating enzyme E2 variant 1 isoform 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:66589); (R-MMU-168638); (R-MMU-202424); (R-MMU-2871837); (R-MMU-445989); (R-MMU-450302); (R-MMU-450321); (R-MMU-5205685); (R-MMU-5607764); (R-MMU-9020702); (R-MMU-937039); (R-MMU-937041); (R-MMU-9646399); (R-MMU-975144); (R-MMU-983168)", "pathway_count": 15, "publication_count": 6, "publication_id_list": "11406273;16307917;17709375;21750661;25153642;26887372", "class_list": "", "function": "Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation (By similarity). Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes (By similarity). Together with RNF135 and UBE2N, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIGI to activate the downstream signaling pathway that leads to interferon beta production (By similarity). UBE2V1-UBE2N together with TRAF3IP2 E3 ubiquitin ligase mediate 'Lys-63'-linked polyubiquitination of TRAF6, a component of IL17A-mediated signaling pathway., [UniProtKB, UniProtKB, PubMed]; Modification of proteins with Lys(63)-linked ubiquitin chains occurs through a UEV1A-independent substrate modification and UEV1A-dependent Lys(63)-linked ubiquitin chain synthesis mechanism, [RefSeq, PubMed]; Work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF/NF-kappaB-regulated apoptosis and the p53/PCNA- and ATM/ATR-Chk1/2-controlled DNA-damage response pathways., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A467;Q8VEB5;Q9ERI7", "ec_number_list": [], "go_molecular_function": "GO:0031624 ubiquitin conjugating enzyme binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0031371 ubiquitin conjugating enzyme complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0070534 protein K63-linked ubiquitination;GO:1902533 positive regulation of intracellular signal transduction;GO:0006301 DNA damage tolerance;GO:1902523 positive regulation of protein K63-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9CZY3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D1D1-1", "uniprot_id": [ { "id": "TSN11_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D1D1", "type": "external" } ], "mass": 28072.0, "length": 253, "protein_name": "Tetraspanin-11", "gene_name": "Tspan11", "organism": "Mouse", "refseq_name": "tetraspanin-11", "refseq_ac": [ { "id": "NP_081019", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081019", "type": "external" } ], "gene_names_uniprotkb": "Tspan11", "gene_names_refseq": "1110014F12Rik; Tspan11", "protein_names_uniprotkb": "Tetraspanin-11; Tspan-11", "protein_names_refseq": "tetraspanin-11; tspan-11", "tax_id": 10090, "disease": "", "pathway": " (mmu:68498)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;30059200;31030082", "class_list": "", "function": "Facilitates focal adhesion assembly to regulate osteoblast alignment and guide bone matrix formation orthogonally to cell orientation., [UniProtKB, PubMed]; Unique arrangement of bone matrix orthogonal to osteoblast alignment controlled by Tspan11-mediated focal adhesion assembly., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0048041 focal adhesion assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9D1D1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D8T4-1", "uniprot_id": [ { "id": "TV23B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D8T4", "type": "external" } ], "mass": 23305.0, "length": 205, "protein_name": "Golgi apparatus membrane protein TVP23 homolog B", "gene_name": "Tvp23b", "organism": "Mouse", "refseq_name": "Golgi apparatus membrane protein TVP23 homolog B isoform 1", "refseq_ac": [ { "id": "NP_080486", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080486", "type": "external" } ], "gene_names_uniprotkb": "Tvp23b; Fam18b1; Fam18b", "gene_names_refseq": "1810036I24Rik; Fam18b1; Fam18b; Tvp23b", "protein_names_uniprotkb": "Golgi apparatus membrane protein TVP23 homolog B", "protein_names_refseq": "Golgi apparatus membrane protein TVP23 homolog B isoform 1; Golgi apparatus membrane protein TVP23 homolog B; family with sequence similarity 18, member B; ortholog of human family with sequence similarity 18 member B FAM18B; protein FAM18B1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67510)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17242355;25428506;34428180;37339972", "class_list": "", "function": "Trans-Golgi protein TVP23B regulates host-microbe interactions via Paneth cell homeostasis and Goblet cell glycosylation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UBJ3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0016192 vesicle-mediated transport;GO:0009306 protein secretion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9D8T4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D9M2-1", "uniprot_id": [ { "id": "UBP12_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D9M2", "type": "external" } ], "mass": 42914.0, "length": 370, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 12", "gene_name": "Usp12", "organism": "Mouse", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 12", "refseq_ac": [ { "id": "NP_035799", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035799", "type": "external" } ], "gene_names_uniprotkb": "Usp12; Ubh1", "gene_names_refseq": "Ubh1; Usp12", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 12; 3.4.19.12; Deubiquitinating enzyme 12; Ubiquitin specific peptidase 12; Ubiquitin thioesterase 12; Ubiquitin-hydrolyzing enzyme 1; Ubiquitin-specific-processing protease 12", "protein_names_refseq": "deubiquitinating enzyme 12; ubiquitin carboxyl-terminal hydrolase 12; ubiquitin specific protease 12; ubiquitin thioesterase 12; ubiquitin thiolesterase 12; ubiquitin-hydrolyzing enzyme 1; ubiquitin-specific-processing protease 12", "tax_id": 10090, "disease": "", "pathway": " (mmu:22217); (R-MMU-5689880)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "12391724;22778262;31219806;33941870;34339675;34759262;35898171", "class_list": "", "function": "De-ubiquitination of p300 by USP12 Critically Enhances METTL3 Expression and Ang II-induced cardiac hypertrophy., [RefSeq, PubMed]; Deubiquitinating enzyme that plays various roles in the regulation of the immune response and inflammation. During TCR engagement and activation, translocates into the cytoplasm and deubiquitinates its substrates LAT and TRAT1 and prevents their lysosome-dependent degradation to stabilize the TCR signaling complex at the plasma membrane. Plays an essential role in the selective LPS-induced macrophage response through the activation of NF-kappa-B pathway. In addition, promotes that antiviral immune response through targeting DNA sensor IFI16 to inhibit its proteasome-dependent degradation. Participates in the interferon signaling pathway and antiviral response independently of its deubiquitinase activity by maintaining nuclear phosphorylated STAT1 levels via inhibition of its CREBBP-mediated acetylation and subsequent dephosphorylation (By similarity). Plays an intrinsic role in promoting the differentiation, activation and proliferation of CD4(+) T-cell by activating the NF-kappa-B signaling pathway through deubiquitinating and stabilizing B-cell lymphoma/leukemia 10/BCL10 (PubMed:33941870). In myeloid-derived suppressor cells promotes the activation of the NF-kappa-B via deubiquitination and stabilization of RELA (PubMed:35898171). Regulates the 'Lys-63'-linked polyubiquitin chains of BAX and thereby modulates the mitochondrial apoptotic process (By similarity). Negative regulator of NOTCH signaling that specifically deubiquitinates non-activated NOTCH receptors to target them for lysosomal degradation; deubiquitination of NOTCH stimulates its transport form late endosomes to lysosomes (PubMed:22778262). Protects neurons against HTT/huntingtin-induced polyglutamine expansion-dependent neurodegeneration through regulation of autophagic flux (By similarity). This function is independent of deubiquitinase activity or of other components of the USP12-WDR20-WDR48 deubiquitinating complex (By similarity). In complex with WDR48, acts as a potential tumor suppressor by positively regulating PHLPP1 stability (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; Product has deubiquitinating enzyme activity and sequence analysis showed 98.3% amino acid identity with human UBH1., [RefSeq, PubMed]; USP12 promotes CD4(+) T cell responses through deubiquitinating and stabilizing BCL10., [RefSeq, PubMed]; USP12 promotes breast cancer angiogenesis by maintaining midkine stability. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q790B0;Q7TNV4;Q80Y43;Q8CBN8", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004197 cysteine-type endopeptidase activity;GO:0004843 cysteine-type deubiquitinase activity;GO:0101005 deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:1905368 peptidase complex", "go_biological_process": "GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0050862 positive regulation of T cell receptor signaling pathway;GO:0031647 regulation of protein stability", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9D9M2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ES63-1", "uniprot_id": [ { "id": "UBP29_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ES63", "type": "external" } ], "mass": 97823.0, "length": 869, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 29", "gene_name": "Usp29", "organism": "Mouse", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 29", "refseq_ac": [ { "id": "NP_001277923", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277923", "type": "external" } ], "gene_names_uniprotkb": "Usp29", "gene_names_refseq": "Ocat; Usp29", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 29; 3.4.19.12; Deubiquitinating enzyme 29; Ubiquitin thioesterase 29; Ubiquitin-specific-processing protease 29", "protein_names_refseq": "ASL1/Usp29 fusion; deubiquitinating enzyme 29; ossification center-associated transcript; ubiquitin carboxyl-terminal hydrolase 29; ubiquitin thioesterase 29; ubiquitin thiolesterase 29; ubiquitin-specific-processing protease 29", "tax_id": 10090, "disease": "", "pathway": " (mmu:57775); (R-MMU-5689880)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10958632;25428506;30919279;32457395;34562326;37304282", "class_list": "", "function": "Deubiquitinase involved in innate antiviral immunity by mediating 'Lys-48'-linked deubiquitination of CGAS, thereby promoting its stabilization., [UniProtKB, PubMed]; Extracellular vesicles derived from melatonin-preconditioned mesenchymal stem cells containing USP29 repair traumatic spinal cord injury by stabilizing NRF2., [RefSeq, PubMed]; Ubiquitin-specific protease 29 attenuates hepatic ischemia-reperfusion injury by mediating TGF-beta-activated kinase 1 deubiquitination. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "C6EQG1", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0004197 cysteine-type endopeptidase activity;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006508 proteolysis;GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0050821 protein stabilization;GO:0031647 regulation of protein stability", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9ES63-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKB1-1", "uniprot_id": [ { "id": "UCHL3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JKB1", "type": "external" } ], "mass": 26152.0, "length": 230, "protein_name": "Ubiquitin carboxyl-terminal hydrolase isozyme L3", "gene_name": "Uchl3", "organism": "Mouse", "refseq_name": "ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform 3", "refseq_ac": [ { "id": "NP_057932", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_057932", "type": "external" } ], "gene_names_uniprotkb": "Uchl3", "gene_names_refseq": "UCH-L3; Uchl3", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase isozyme L3; 3.4.19.12; UCH-L3; Ubiquitin thioesterase L3", "protein_names_refseq": "ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform 3; ubiquitin carboxyl-terminal hydrolase isozyme L3; ubiquitin thioesterase L3; ubiquitin thiolesterase", "tax_id": 10090, "disease": "late onset Parkinson's disease (Disease Ontology:DOID:0060892); Parkinson's disease (Disease Ontology:DOID:14330); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:50933); (R-MMU-5689603); (R-MMU-8866652); (R-MMU-8951664)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "10713173;11341770;15884048;16816367;17460351;17967898;19837878;20380862;21750661;21762696;34428180;37524875;37740194;9790970", "class_list": "", "function": "Activation of CTNNB1 by deubiquitinase UCHL3-mediated stabilization facilitates bladder cancer progression. Publication Status: Online-Only, [RefSeq, PubMed]; Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins (By similarity). Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8 (By similarity). Has a 10-fold preference for Arg and Lys at position P3'', and exhibits a preference towards 'Lys-48'-linked ubiquitin chains (By similarity). Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurodegenerative disorders (PubMed:21762696). Involved in DNA repair via homologous recombination (HR) by mediating deubiquitination of RAD51 in response to DNA damage, promoting interaction between RAD51 and BRCA2 (By similarity). Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling (PubMed:17967898). Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis (PubMed:19837878). Required for stress-response retinal, skeletal muscle and germ cell maintenance (PubMed:16816367, PubMed:17460351). May be involved in working memory (PubMed:15884048)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; The deubiquitinase UCHL3 mediates p300-dependent chemokine signaling in alveolar type II cells to promote pulmonary fibrosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9EQX7", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" } ], "go_molecular_function": "GO:0008233 peptidase activity;GO:0043130 ubiquitin binding;GO:0004843 cysteine-type deubiquitinase activity;GO:0101005 deubiquitinase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0016579 protein deubiquitination;GO:0032869 cellular response to insulin stimulus;GO:0045600 positive regulation of fat cell differentiation;GO:0042755 eating behavior;GO:0060041 retina development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9JKB1-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2B2-1", "uniprot_id": [ { "id": "UCP5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z2B2", "type": "external" } ], "mass": 36286.0, "length": 325, "protein_name": "Brain mitochondrial carrier protein 1", "gene_name": "Slc25a14", "organism": "Mouse", "refseq_name": "brain mitochondrial carrier protein 1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001159922", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159922", "type": "external" } ], "gene_names_uniprotkb": "Slc25a14; Bmcp1; Ucp5", "gene_names_refseq": "BMCP1; Slc25a14; UCP5L; UCP5S; UCP5", "protein_names_uniprotkb": "Brain mitochondrial carrier protein 1; BMCP-1; Mitochondrial uncoupling protein 5; Solute carrier family 25 member 14; UCP 5", "protein_names_refseq": "brain mitochondrial carrier protein 1 isoform 1 precursor; brain mitochondrial carrier protein 1; mitochondrial uncoupling protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:20523); (R-MMU-167826)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10928996;11701769;21750661;34203471;9852133", "class_list": "", "function": "Transports inorganic anions (sulfate, sulfite, thiosulfate and phosphate) and, to a lesser extent, a variety of dicarboxylates (e.g. malonate, malate and citramalate) and, even more so, aspartate and glutamate and tricarboxylates. May catalyze the export of sulfite and thiosulfate (the hydrogen sulfide degradation products) from the mitochondria, thereby modulating the level of the hydrogen sulfide. Also can mediate a very low unidirectional transport of anions including sulfate, phosphate, (S)-malate, citrate, L-aspartate and L-glutamate. Maintains oxidative balance (through uncoupling activities) and ATP production (by modifying mitochondrial membrane potential). Is able to transport protons across lipid membranes. Also exhibits transmembrane chloride transport activity to a lesser extent (By similarity). May modify mitochondrial respiratory efficiency and mitochondrial oxidant production (PubMed:11701769)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9ESI8", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0015078 proton transmembrane transporter activity;GO:0005452 solute:inorganic anion antiporter activity;GO:0015108 chloride transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005740 mitochondrial envelope;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:1900407 regulation of cellular response to oxidative stress;GO:0015698 inorganic anion transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9Z2B2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6W8I0-1", "uniprot_id": [ { "id": "YJEN3_MOUSE", "url": "https://www.uniprot.org/uniprot/F6W8I0", "type": "external" } ], "mass": 27016.0, "length": 251, "protein_name": "YjeF N-terminal domain-containing protein 3", "gene_name": "Yjefn3", "organism": "Mouse", "refseq_name": "yjeF N-terminal domain-containing protein 3", "refseq_ac": [ { "id": "NP_001340859", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001340859", "type": "external" } ], "gene_names_uniprotkb": "Yjefn3; Aibp2", "gene_names_refseq": "Gm175; YjeF_N3; Yjefn3; hYjeF_N3", "protein_names_uniprotkb": "YjeF N-terminal domain-containing protein 3; ApoA-I-binding protein 2; YjeF_N3; hYjeF_N3", "protein_names_refseq": "apoA-I-binding protein 2; yjeF N-terminal domain-containing protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:234365)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;8889548", "class_list": "", "function": "May accelerate cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis. May orchestrate hematopoietic stem and progenitor cell emergence from the hemogenic endothelium, a type of specialized endothelium manifesting hematopoietic potential. YJEFN3-mediated cholesterol efflux activates endothelial SREBF2, the master transcription factor for cholesterol biosynthesis, which in turn transactivates NOTCH and promotes hematopoietic stem and progenitor cell emergence (By similarity). May play a role in spermiogenesis and oogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "J3QM68;Q8R2K0", "ec_number_list": [], "go_molecular_function": "GO:0052856 NAD(P)HX epimerase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006869 lipid transport;GO:0016525 negative regulation of angiogenesis;GO:0002040 sprouting angiogenesis;GO:0071425 hematopoietic stem cell proliferation;GO:0010874 regulation of cholesterol efflux", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F6W8I0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NZF1-1", "uniprot_id": [ { "id": "ZC11A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6NZF1", "type": "external" } ], "mass": 86492.0, "length": 792, "protein_name": "Zinc finger CCCH domain-containing protein 11A", "gene_name": "Zc3h11a", "organism": "Mouse", "refseq_name": "zinc finger CCCH domain-containing protein 11A", "refseq_ac": [ { "id": "NP_001263696", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263696", "type": "external" } ], "gene_names_uniprotkb": "Zc3h11a; Kiaa0663", "gene_names_refseq": "1110003F06Rik; 5730454B08Rik; G630041M05Rik; Zc3h11a; Zc3hdc11a; Zc3hh11a; mKIAA0663", "protein_names_uniprotkb": "Zinc finger CCCH domain-containing protein 11A", "protein_names_refseq": "zinc finger CCCH domain-containing protein 11A", "tax_id": 10090, "disease": "", "pathway": " (mmu:70579); (R-MMU-159236); (R-MMU-72187)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "21183079;21750661;25153642;25605945;34428180;34887587;35820727;37252988;37356722", "class_list": "", "function": "Ablation of ZC3H11A causes early embryonic lethality and dysregulation of metabolic processes., [RefSeq, PubMed]; The RNA-binding protein ZC3H11A interacts with the nuclear poly(A)-binding protein PABPN1 and alters polyadenylation of viral transcripts., [RefSeq, PubMed]; Through its association with TREX complex components, may participate in the export and post-transcriptional coordination of selected mRNA transcripts, including those required to maintain the metabolic processes in embryonic cells (PubMed:37252988). Binds RNA (PubMed:37252988)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6NXW9;Q6PDR6;Q80TU7;Q8C5L5;Q99JN6", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q6NZF1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64726-1", "uniprot_id": [ { "id": "ZA2G_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64726", "type": "external" } ], "mass": 35332.0, "length": 307, "protein_name": "Zinc-alpha-2-glycoprotein", "gene_name": "Azgp1", "organism": "Mouse", "refseq_name": "zinc-alpha-2-glycoprotein precursor", "refseq_ac": [ { "id": "NP_038506", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038506", "type": "external" } ], "gene_names_uniprotkb": "Azgp1", "gene_names_refseq": "Azgp1; Zag", "protein_names_uniprotkb": "Zinc-alpha-2-glycoprotein; Zn-alpha-2-GP; Zn-alpha-2-glycoprotein", "protein_names_refseq": "major histocompatibility complex class I-like protein; zinc-alpha-2-glycoprotein precursor; zn-alpha-2-GP", "tax_id": 10090, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); prostate cancer (Disease Ontology:DOID:10283); prostate carcinoma (Disease Ontology:DOID:10286); epilepsy (Disease Ontology:DOID:1826); colon cancer (Disease Ontology:DOID:219); acute kidney failure (Disease Ontology:DOID:3021); temporal lobe epilepsy (Disease Ontology:DOID:3328); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung adenocarcinoma (Disease Ontology:DOID:3910); liver cirrhosis (Disease Ontology:DOID:5082); stomach carcinoma (Disease Ontology:DOID:5517); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); chronic kidney disease (Disease Ontology:DOID:784); colorectal cancer (Disease Ontology:DOID:9256); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:12007); (R-MMU-5223345)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "17330941;21750661;26495903;26740625;32863292;34428180;35255519;38491721;7797272;7852290", "class_list": "", "function": "AZGP1 Aggravates Macrophage M1 Polarization and Pyroptosis in Periodontitis., [RefSeq, PubMed]; Adipokine ZAG Alters Depression-Like Behavior by Regulating Oxidative Stress in Hippocampus., [RefSeq, PubMed]; Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers., [UniProtKB]; Zinc-alpha2-glycoprotein promotes skeletal muscle lipid metabolism in cold-stressed mice., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9DBB7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0006955 immune response;GO:0007155 cell adhesion;GO:0040014 regulation of multicellular organism growth;GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q64726-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PD05-1", "uniprot_id": [ { "id": "ZN821_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PD05", "type": "external" } ], "mass": 46828.0, "length": 413, "protein_name": "Zinc finger protein 821", "gene_name": "Zfp821; Znf821", "organism": "Mouse", "refseq_name": "zinc finger protein 821 isoform a", "refseq_ac": [ { "id": "NP_001161418", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161418", "type": "external" } ], "gene_names_uniprotkb": "Zfp821; Znf821; Zfp821", "gene_names_refseq": "4930566A11Rik; Zfp821; Znf821", "protein_names_uniprotkb": "Zinc finger protein 821", "protein_names_refseq": "zinc finger protein 821 isoform a", "tax_id": 10090, "disease": "", "pathway": " (mmu:75871)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9Q0F1;Q3UWR1", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0016607 nuclear speck;GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6PD05-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0PK84-1", "uniprot_id": [ { "id": "ZDH22_MOUSE", "url": "https://www.uniprot.org/uniprot/A0PK84", "type": "external" } ], "mass": 29318.0, "length": 263, "protein_name": "Palmitoyltransferase ZDHHC22", "gene_name": "Zdhhc22", "organism": "Mouse", "refseq_name": "palmitoyltransferase ZDHHC22", "refseq_ac": [ { "id": "NP_001074412", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074412", "type": "external" } ], "gene_names_uniprotkb": "Zdhhc22; Gm262", "gene_names_refseq": "Gm262; Zdhhc22", "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC22; 2.3.1.225; DHHC-22; Zinc finger DHHC domain-containing protein 22; zDHHC22", "protein_names_refseq": "DHHC-22; palmitoyltransferase ZDHHC22; putative palmitoyltransferase ZDHHC22; zinc finger DHHC domain-containing protein 22", "tax_id": 10090, "disease": "", "pathway": " (mmu:238331)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29287726", "class_list": "", "function": "Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates and be involved in a variety of cellular processes (By similarity). Catalyzes the palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane (By similarity). Might also mediate palmitoylation of CNN3 (Probable)., [UniProtKB, PubMed, UniProtKB]; Taken together, our results suggest that palmitoylation by ZDHHC22 at C241 in the CCN3 TSP1 domain may be required for the secretion of CCN3. Aberrant palmitoylation induces intracellular accumulation of CCN3, inhibiting neuronal axon growth., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" }, { "id": "6.3.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.1.2", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0019706 protein-cysteine S-palmitoyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0006612 protein targeting to membrane;GO:0018345 protein palmitoylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0PK84-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2A5K6-1", "uniprot_id": [ { "id": "ZN335_MOUSE", "url": "https://www.uniprot.org/uniprot/A2A5K6", "type": "external" } ], "mass": 145603.0, "length": 1337, "protein_name": "Zinc finger protein 335", "gene_name": "Zfp335; Znf335", "organism": "Mouse", "refseq_name": "zinc finger protein 335", "refseq_ac": [ { "id": "NP_950192", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_950192", "type": "external" } ], "gene_names_uniprotkb": "Zfp335; Znf335; Zfp335", "gene_names_refseq": "1810045J01Rik; NIF-1; Nif1; Zfp335; Znf335", "protein_names_uniprotkb": "Zinc finger protein 335; NIF-1; NRC-interacting factor 1", "protein_names_refseq": "NRC-interacting factor 1; zinc finger protein 335", "tax_id": 10090, "disease": "primary autosomal recessive microcephaly 10 (Disease Ontology:DOID:0070294)", "pathway": " (mmu:329559)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "21750661;23178126;25329792;25343476;30059200;35914836;37843279;38598411", "class_list": "", "function": "Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters (By similarity). Enhances ligand-dependent transcriptional activation by nuclear hormone receptors (By similarity). Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST (PubMed:23178126). Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation (By similarity)., [UniProtKB, PubMed, UniProtKB]; P35 interacts with NIF-1 and regulates the subcellular localization of the protein independent of Cdk5-dependent phosphorylation. ...reveal a new mechanism of p35 in transcriptional regulation that does not require the kinase activity of Cdk5 Publication Status: Online-Only, [RefSeq, PubMed]; The Transcription Factor Zfp335 Promotes Differentiation and Persistence of Memory CD8(+) T Cells by Regulating TCF-1., [RefSeq, PubMed]; The Transcription Factor Zfp335 Promotes Differentiation and Survival of Effector Th1 Cells by Directly Regulating Lmna Expression., [RefSeq, PubMed]; Zfp335 establishes eTreg lineage and neonatal immune tolerance by targeting Hadha-mediated fatty acid oxidation. Publication Status: Online-Only, [RefSeq, PubMed]; Zinc finger protein Zfp335 is required for the formation of the naive T cell compartment. Publication Status: Online-Only, [RefSeq, PubMed]; Znf335 null mice are embryonically lethal, and conditional knockout leads to severely reduced cortical size., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B2RXR9;Q3TZT1", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0035097 histone methyltransferase complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0048812 neuron projection morphogenesis;GO:0007420 brain development;GO:0040029 epigenetic regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A2A5K6-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2A791-1", "uniprot_id": [ { "id": "ZMYM4_MOUSE", "url": "https://www.uniprot.org/uniprot/A2A791", "type": "external" } ], "mass": 172438.0, "length": 1549, "protein_name": "Zinc finger MYM-type protein 4", "gene_name": "Zmym4", "organism": "Mouse", "refseq_name": "zinc finger MYM-type protein 4 isoform 1", "refseq_ac": [ { "id": "NP_001107871", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107871", "type": "external" } ], "gene_names_uniprotkb": "Zmym4; Kiaa0425; Zfp262; Znf262", "gene_names_refseq": "6330503C17Rik; CDIR; D630001M21; MYM; Zfp262; Zmym4; Znf262; mKIAA0425", "protein_names_uniprotkb": "Zinc finger MYM-type protein 4; Zinc finger protein 262", "protein_names_refseq": "cell death inhibiting RNA; zinc finger MYM-type protein 4 isoform 1; zinc finger MYM-type protein 4; zinc finger protein 262", "tax_id": 10090, "disease": "", "pathway": " (mmu:67785)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21183079;21750661;31219806;34428180;40997131", "class_list": "", "function": "Required for regulation of cell morphology and cytoskeletal organization., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UFQ2;Q6ZQB9;Q80X47;Q8K1H5", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "", "go_biological_process": "GO:0007010 cytoskeleton organization;GO:0022604 regulation of cell morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A2A791-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2A884-1", "uniprot_id": [ { "id": "ZEP3_MOUSE", "url": "https://www.uniprot.org/uniprot/A2A884", "type": "external" } ], "mass": 253413.0, "length": 2348, "protein_name": "Transcription factor HIVEP3", "gene_name": "Hivep3", "organism": "Mouse", "refseq_name": "transcription factor HIVEP3", "refseq_ac": [ { "id": "NP_034787", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034787", "type": "external" } ], "gene_names_uniprotkb": "Hivep3; KBP1; Kiaa1555; Krc; Rc; Zas3; shn3", "gene_names_refseq": "2900056N03Rik; A130075N07; E030045D18Rik; Hivep3; KBP-1; KBP1; Krc; Rc; Schnurri-3; Shn3; Zas3", "protein_names_uniprotkb": "Transcription factor HIVEP3; Human immunodeficiency virus type I enhancer-binding protein 3 homolog; KB-binding and recognition component; KBP-1; Kappa-B and V(D)J recombination signal sequences-binding protein; Kappa-binding protein 1; Recombinant component; Schnurri-3; Zinc finger protein ZAS3", "protein_names_refseq": "KB-binding and recognition component; KB-binding and regognition component; human immunodeficiency virus type I enhancer-binding protein 3 homolog; kappa B and Rss recognition component; kappa-B and V(D)J recombination signal sequences-binding protein; kappa-binding protein 1; recombinant component; transcription factor HIVEP3; zinc finger protein ZAS3", "tax_id": 10090, "disease": "juvenile polyposis syndrome (Disease Ontology:DOID:0050787)", "pathway": " (mmu:16656)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "10625627;11035930;11801660;11804591;12001065;12193271;14530385;14707112;15627499;16728642;21750661;22517741;22645316;27802388;32848054;35820727;36084651;37963919;39107299;39183236;40021952;40885482;8255760;8812474;9862992", "class_list": "", "function": "Bone controls browning of white adipose tissue and protects from diet-induced obesity through Schnurri-3-regulated SLIT2 secretion. Publication Status: Online-Only, [RefSeq, PubMed]; KRC overexpression inhibits while antisense or dominant-negative KRC enhances NFkappaB-dependent transactivation and JNK phosphorylation and consequently, apoptosis and cytokine gene expression, [RefSeq, PubMed]; Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Also binds to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and pro-inflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Schnurri-3 drives tumor growth and invasion in cancer cells expressing interleukin-13 receptor alpha 2. Publication Status: Online-Only, [RefSeq, PubMed]; Schnurri-3 inhibition rescues skeletal fragility and vascular skeletal stem cell niche pathology in the OIM model of osteogenesis imperfecta. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 8, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 8, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 8, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "A2MZW0;Q69ZG6;Q6SNP9", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0035914 skeletal muscle cell differentiation", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "A2A884-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P560-1", "uniprot_id": [ { "id": "ZN182_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P560", "type": "external" } ], "mass": 72439.0, "length": 627, "protein_name": "Zinc finger protein 182", "gene_name": "Zfp182; Znf182", "organism": "Mouse", "refseq_name": "zinc finger protein 182", "refseq_ac": [ { "id": "NP_001013405", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013405", "type": "external" } ], "gene_names_uniprotkb": "Zfp182; Znf182; Zfp182; Znf21", "gene_names_refseq": "6330583I20Rik; Zfp182; Znf182", "protein_names_uniprotkb": "Zinc finger protein 182; Zinc finger protein 21", "protein_names_refseq": "zinc finger protein 182; zinc finger protein 21", "tax_id": 10090, "disease": "", "pathway": " (mmu:319535)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;30059200;34428180", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U2Y4;Q8CCU4", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0031981 nuclear lumen;GO:0005634 nucleus;GO:0005856 cytoskeleton", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0009891 positive regulation of biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6P560-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P59326-1", "uniprot_id": [ { "id": "YTHD1_MOUSE", "url": "https://www.uniprot.org/uniprot/P59326", "type": "external" } ], "mass": 60879.0, "length": 559, "protein_name": "YTH domain-containing family protein 1", "gene_name": "Ythdf1", "organism": "Mouse", "refseq_name": "YTH domain-containing family protein 1", "refseq_ac": [ { "id": "NP_776122", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776122", "type": "external" } ], "gene_names_uniprotkb": "Ythdf1", "gene_names_refseq": "2210410K23Rik; 8030473O16; Ythdf1", "protein_names_uniprotkb": "YTH domain-containing family protein 1; DACA-1 homolog; Dermatomyositis associated with cancer putative autoantigen 1 homolog", "protein_names_refseq": "DACA-1 homolog; YTH domain family 1; YTH domain family protein 1; YTH domain-containing family protein 1; dermatomyositis associated with cancer putative autoantigen 1 homolog", "tax_id": 10090, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:228994)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "20173027;21750661;22872234;25428506;30059200;30084848;30401835;30728504;30779550;30843071;31219806;31599954;32782141;32848054;32943573;34428180;34678516;35820727;35822049;36852467;39304892;40021952;40885482", "class_list": "", "function": "Anti-tumour immunity controlled through mRNA m(6)A methylation and YTHDF1 in dendritic cells Erratum:[Nature. 2019 Apr;568(7751):E3. doi: 10.1038/s41586-019-1046-1. PMID: 30911170], [RefSeq, PubMed]; Our findings identify a mechanism that YTHDF1-mediated translation of m6A-modified Robo3.1 mRNA controls pre-crossing axon guidance in spinal cord, [RefSeq, PubMed]; Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing., [UniProtKB, UniProtKB]; Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, and regulates their stability (PubMed:30401835, PubMed:32943573). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing (PubMed:30401835, PubMed:32943573). Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex (By similarity). The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) share m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation (PubMed:32943573). Required to facilitate learning and memory formation in the hippocampus by binding to m6A-containing neuronal mRNAs (PubMed:30401835). Acts as a regulator of axon guidance by binding to m6A-containing ROBO3 transcripts (PubMed:30843071). Acts as a negative regulator of antigen cross-presentation in myeloid dendritic cells (PubMed:30728504). In the context of tumorigenesis, negative regulation of antigen cross-presentation limits the anti-tumor response by reducing efficiency of tumor-antigen cross-presentation (PubMed:30728504). Promotes formation of phase-separated membraneless compartments, such as P-bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation (By similarity). The resulting mRNA-YTHDF complexes then partition into different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; YTHDF1 facilitates translation of m(6)A-methylated neuronal mRNAs in response to neuronal stimulation, and this process contributes to learning and memory, [RefSeq, PubMed]; YTHDF1 in periaqueductal gray inhibitory neurons contributes to morphine withdrawal responses in mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3T9E2", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0043022 ribosome binding;GO:1990247 N6-methyladenosine-containing RNA reader activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0000932 P-body;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:1902667 regulation of axon guidance;GO:0007612 learning;GO:0007613 memory;GO:0043488 regulation of mRNA stability;GO:0045727 positive regulation of translation", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P59326-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2CE44-1", "uniprot_id": [ { "id": "ZXDB_MOUSE", "url": "https://www.uniprot.org/uniprot/A2CE44", "type": "external" } ], "mass": 90376.0, "length": 873, "protein_name": "Zinc finger X-linked protein ZXDB", "gene_name": "Zxdb", "organism": "Mouse", "refseq_name": "zinc finger X-linked protein ZXDB", "refseq_ac": [ { "id": "NP_001074942", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074942", "type": "external" } ], "gene_names_uniprotkb": "Zxdb", "gene_names_refseq": "Zxda; Zxdb", "protein_names_uniprotkb": "Zinc finger X-linked protein ZXDB", "protein_names_refseq": "zinc finger X-linked protein ZXDA/ZXDB; zinc finger X-linked protein ZXDB", "tax_id": 10090, "disease": "", "pathway": " (mmu:668166)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "20485683;24129315;25428506;31219806;34428180", "class_list": "", "function": "Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V1M7;Q8CEQ1", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0003712 transcription coregulator activity;GO:0070742 C2H2 zinc finger domain binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A2CE44-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7KBS4-1", "uniprot_id": [ { "id": "ZSC4D_MOUSE", "url": "https://www.uniprot.org/uniprot/A7KBS4", "type": "external" } ], "mass": 58000.0, "length": 506, "protein_name": "Zinc finger and SCAN domain containing protein 4D", "gene_name": "Zscan4d", "organism": "Mouse", "refseq_name": "zinc finger and SCAN domain containing protein 4D", "refseq_ac": [ { "id": "NP_001093656", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093656", "type": "external" } ], "gene_names_uniprotkb": "Zscan4d", "gene_names_refseq": "EG545913; Zscan4d", "protein_names_uniprotkb": "Zinc finger and SCAN domain containing protein 4D", "protein_names_refseq": "zinc finger and SCAN domain containing protein 4D", "tax_id": 10090, "disease": "", "pathway": " (mmu:545913)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17553482;18580041;23739662;26997646", "class_list": "", "function": "Data show that zinc finger protein 42 (Rex1) and zinc finger and SCAN domain containing 4D/4C (Zscan4D/4C) correlate with the cell-cycle length under different mechanisms., [RefSeq, PubMed]; Inhibiting the first round increased the expression levels of hsp70.1, eif-1a and zscan4d but decreased that of muerv, while inhibiting the second round increased the expression levels of all four genes., [RefSeq, PubMed]; These results indicate the active roles of Zscan4 in the long-term maintenance of embryonic stem cell potency.[Zscan4], [RefSeq, PubMed]; Transcription factor required to regulate early development. Binds telomeres and plays a key role in genomic stability by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0010833 telomere maintenance via telomere lengthening;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A7KBS4-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TQG0-1", "uniprot_id": [ { "id": "ZBTB5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TQG0", "type": "external" } ], "mass": 73215.0, "length": 670, "protein_name": "Zinc finger and BTB domain-containing protein 5", "gene_name": "Zbtb5", "organism": "Mouse", "refseq_name": "zinc finger and BTB domain-containing protein 5", "refseq_ac": [ { "id": "NP_001156755", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156755", "type": "external" } ], "gene_names_uniprotkb": "Zbtb5; Kiaa0354", "gene_names_refseq": "5930421I10; 9430083K24Rik; Zbtb5; mKIAA0354", "protein_names_uniprotkb": "Zinc finger and BTB domain-containing protein 5; Transcription factor ZNF-POZ", "protein_names_refseq": "expressed in brain and neural tube; transcription factor ZNF-POZ; zinc finger and BTB domain-containing protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:230119)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25428506;35820727", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TVR7;Q6GV09;Q8BIB5", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7TQG0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RRE4-1", "uniprot_id": [ { "id": "Z518B_MOUSE", "url": "https://www.uniprot.org/uniprot/B2RRE4", "type": "external" } ], "mass": 118997.0, "length": 1077, "protein_name": "Zinc finger protein 518B", "gene_name": "Zfp518b; Znf518b", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Zfp518b; Znf518b; Kiaa1729; Zfp518b", "gene_names_refseq": "", "protein_names_uniprotkb": "Zinc finger protein 518B", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:100515)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21750661;22872234;25428506;25680957;30084848;30779550;31156619", "class_list": "", "function": "Through its association with the EHMT1-EHMT2/G9A and PRC2/EED-EZH2 histone methyltransferase complexes may function in gene silencing, regulating repressive post-translational methylation of histone tails at promoters of target genes., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q69ZC1", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "B2RRE4-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RRF6-1", "uniprot_id": [ { "id": "Z518A_MOUSE", "url": "https://www.uniprot.org/uniprot/B2RRF6", "type": "external" } ], "mass": 165604.0, "length": 1478, "protein_name": "Zinc finger protein 518A", "gene_name": "Znf518a", "organism": "Mouse", "refseq_name": "zinc finger protein 518A", "refseq_ac": [ { "id": "NP_082595", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082595", "type": "external" } ], "gene_names_uniprotkb": "Znf518a; Kiaa0335; Zfp518a; Zfp518; Znf518", "gene_names_refseq": "2810401C22Rik; 6330417C12Rik; Zfp518a; Zfp518; Znf518a; Znf518; mKIAA0335", "protein_names_uniprotkb": "Zinc finger protein 518A", "protein_names_refseq": "zinc finger protein 518A; zinc finger protein 518", "tax_id": 10090, "disease": "", "pathway": " (mmu:72672)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "25428506;25680957;30084848;31219806;34428180", "class_list": "", "function": "Through its association with the EHMT1-EHMT2/G9A and PRC2/EED-EZH2 histone methyltransferase complexes may function in gene silencing, regulating repressive post-translational methylation of histone tails at promoters of target genes., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9CSF6", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "B2RRF6-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RVL6-1", "uniprot_id": [ { "id": "ZCH24_MOUSE", "url": "https://www.uniprot.org/uniprot/B2RVL6", "type": "external" } ], "mass": 26961.0, "length": 241, "protein_name": "Zinc finger CCHC domain-containing protein 24", "gene_name": "Zcchc24", "organism": "Mouse", "refseq_name": "zinc finger CCHC domain-containing protein 24", "refseq_ac": [ { "id": "NP_001094903", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094903", "type": "external" } ], "gene_names_uniprotkb": "Zcchc24", "gene_names_refseq": "2310047A01Rik; Zcchc24", "protein_names_uniprotkb": "Zinc finger CCHC domain-containing protein 24", "protein_names_refseq": "zinc finger CCHC domain-containing protein 24", "tax_id": 10090, "disease": "", "pathway": " (mmu:71918)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "25428506;30084848;34428180;36852467", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "B2RVL6-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RXC5-1", "uniprot_id": [ { "id": "ZN382_MOUSE", "url": "https://www.uniprot.org/uniprot/B2RXC5", "type": "external" } ], "mass": 66547.0, "length": 579, "protein_name": "Zinc finger protein 382", "gene_name": "Zfp382; Znf382", "organism": "Mouse", "refseq_name": "zinc finger protein 382 isoform 1", "refseq_ac": [ { "id": "NP_001074476", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074476", "type": "external" } ], "gene_names_uniprotkb": "Zfp382; Znf382; Zfp382", "gene_names_refseq": "4930428B01Rik; 5930415A09Rik; KS1; Zfp382; Znf382", "protein_names_uniprotkb": "Zinc finger protein 382; KRAB/zinc finger suppressor protein 1; KS1; Multiple zinc finger and krueppel-associated box protein KS1", "protein_names_refseq": "KRAB/zinc finger suppressor protein 1; multiple zinc finger and krueppel-associated box protein KS1; zinc finger protein 382 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:233060); (R-MMU-212436); (R-MMU-9843940)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "11154279;21750661;34762123", "class_list": "", "function": "Functions as a sequence-specific transcriptional repressor., [UniProtKB]; ZNF382 controls mouse neuropathic pain via silencer-based epigenetic inhibition of Cxcl13 in DRG neurons., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UYY9", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "B2RXC5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2HJ10-1", "uniprot_id": [ { "id": "ZNT2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q2HJ10", "type": "external" } ], "mass": 40639.0, "length": 371, "protein_name": "Proton-coupled zinc antiporter SLC30A2", "gene_name": "Slc30a2", "organism": "Mouse", "refseq_name": "proton-coupled zinc antiporter SLC30A2 isoform 1", "refseq_ac": [ { "id": "NP_001034766", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034766", "type": "external" } ], "gene_names_uniprotkb": "Slc30a2; Znt2", "gene_names_refseq": "Slc30a2; ZnT-2; Znt2", "protein_names_uniprotkb": "Proton-coupled zinc antiporter SLC30A2; Solute carrier family 30 member 2; Zinc transporter 2; ZnT-2", "protein_names_refseq": "proton-coupled zinc antiporter SLC30A2 isoform 1; proton-coupled zinc antiporter SLC30A2; solute carrier family 30 member 2; zinc transporter 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:230810)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17065149;19496757;20133611;21289295;21750661;29718697", "class_list": "", "function": "A mutation in SLC30A2 (ZnT-2) may have a role in transient neonatal zinc deficiency, [RefSeq, PubMed]; Electroneutral proton-coupled antiporter concentrating zinc ions into a variety of intracellular organelles including endosomes, zymogen granules and mitochondria. Thereby, plays a crucial role in cellular zinc homeostasis to confer upon cells protection against its potential cytotoxicity (PubMed:21289295). Regulates the zinc concentration of milk, through the transport of zinc ions into secretory vesicles of mammary cells (Probable). By concentrating zinc ions into lysosomes participates to lysosomal-mediated cell death during early mammary gland involution (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Electroneutral proton-coupled antiporter mediating the efflux of zinc ions through the plasma membrane., [UniProtKB, PubMed]; ZnT2 is a novel regulator of vacuolar ATPase assembly, driving lysosome biogenesis, acidification, and tissue remodeling during the initiation of mammary gland involution., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3Z5N0", "ec_number_list": [], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0140826 zinc:proton antiporter activity;GO:0008324 monoatomic cation transmembrane transporter activity", "go_cellular_component": "GO:0099503 secretory vesicle;GO:0005737 cytoplasm;GO:0005743 mitochondrial inner membrane;GO:0005886 plasma membrane;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0071577 zinc ion transmembrane transport;GO:0006829 zinc ion transport;GO:0010043 response to zinc ion;GO:0006882 intracellular zinc ion homeostasis;GO:0140882 zinc export across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q2HJ10-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6A085-1", "uniprot_id": [ { "id": "ZN629_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6A085", "type": "external" } ], "mass": 96033.0, "length": 867, "protein_name": "Zinc finger protein 629", "gene_name": "Zfp629; Znf629", "organism": "Mouse", "refseq_name": "zinc finger protein 629 isoform a", "refseq_ac": [ { "id": "NP_796200", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796200", "type": "external" } ], "gene_names_uniprotkb": "Zfp629; Znf629; Kiaa0326; Zfp629", "gene_names_refseq": "9330199A09Rik; Zfp629; Znf629", "protein_names_uniprotkb": "Zinc finger protein 629", "protein_names_refseq": "zinc finger protein 629 isoform a", "tax_id": 10090, "disease": "", "pathway": " (mmu:320683)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BG88;Q8BIR0", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6A085-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62513-1", "uniprot_id": [ { "id": "ZN260_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62513", "type": "external" } ], "mass": 46443.0, "length": 407, "protein_name": "Zinc finger protein 260", "gene_name": "Zfp260; Znf260", "organism": "Mouse", "refseq_name": "zinc finger protein 260", "refseq_ac": [ { "id": "NP_036111", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036111", "type": "external" } ], "gene_names_uniprotkb": "Zfp260; Znf260; Zfp260", "gene_names_refseq": "Ozrf1; PEX1; Zfp260; Zfp63; Znf260", "protein_names_uniprotkb": "Zinc finger protein 260; Zfp-260", "protein_names_refseq": "zfp-260; zinc finger protein 260", "tax_id": 10090, "disease": "", "pathway": " (mmu:26466)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10449921;16166646;21051538;21750661", "class_list": "", "function": "Pex1 is a novel nuclear effector of ET-1 signaling and may be a regulator of the early stages of cardiac hypertrophy, [RefSeq, PubMed]; Transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. Binds to PE response elements (PERE) present in the promoter of genes such as ANF/NPPA and acts as a direct transcriptional activator of NPPA. Also acts as a cofactor with GATA4, a key cardiac regulator., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U170;Q8C2Q6;Q9R2B4", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q62513-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q5K9-1", "uniprot_id": [ { "id": "YTDC1_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q5K9", "type": "external" } ], "mass": 85649.0, "length": 736, "protein_name": "YTH domain-containing protein 1", "gene_name": "Ythdc1", "organism": "Mouse", "refseq_name": "YTH domain-containing protein 1 isoform 2", "refseq_ac": [ { "id": "NP_001334304", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334304", "type": "external" } ], "gene_names_uniprotkb": "Ythdc1; Kiaa1966", "gene_names_refseq": "A730098D12Rik; Ythdc1; mKIAA1966", "protein_names_uniprotkb": "YTH domain-containing protein 1", "protein_names_refseq": "YTH domain-containing protein 1 isoform 2; YTH domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:231386); (R-MMU-9930044)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "21183079;21750661;29262316;29799838;34428180;39236791;39627609;40128797;40355558;40997131", "class_list": "", "function": "Functional role of lncRNA MEG3 on pyroptosis through interacting with EZH2 and YTHDC1 in postoperative cognitive dysfunction., [RefSeq, PubMed]; Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:29262316, PubMed:29799838). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:29799838). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (By similarity). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (By similarity). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (By similarity). May also regulate alternative splice site selection (By similarity). Also involved in nuclear export of m6A-containing mRNAs via interaction with SRSF3: interaction with SRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (By similarity). Involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs (PubMed:29262316). Also recognizes and binds m6A on other RNA molecules (By similarity). Involved in random X inactivation mediated by Xist RNA: recognizes and binds m6A-containing Xist and promotes transcription repression activity of Xist (By similarity). Also recognizes and binds m6A-containing single-stranded DNA (By similarity). Involved in germline development: required for spermatogonial development in males and oocyte growth and maturation in females, probably via its role in alternative splicing (PubMed:29799838). Independently of its N6-methyladenosine-containing RNA reader activity, it regulates PPARG stability by preventing its interaction with the E3 ubiquitin ligase ARIH2, thereby protecting it from ubiquitin-mediated proteasomal degradation and contributing to brown adipose tissue (BAT) development and energy homeostasis (PubMed:40355558)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9PW44;E9Q7Z8;Q69Z54;Q80V25;Q8R5E6", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:1990247 N6-methyladenosine-containing RNA reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0016607 nuclear speck;GO:0016604 nuclear body", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0006406 mRNA export from nucleus;GO:0007283 spermatogenesis;GO:0050873 brown fat cell differentiation;GO:0010608 post-transcriptional regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "E9Q5K9-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4VA44-1", "uniprot_id": [ { "id": "ZN664_MOUSE", "url": "https://www.uniprot.org/uniprot/Q4VA44", "type": "external" } ], "mass": 30326.0, "length": 261, "protein_name": "Zinc finger protein 664", "gene_name": "Zfp664; Znf664", "organism": "Mouse", "refseq_name": "zinc finger protein 664", "refseq_ac": [ { "id": "NP_001075219", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075219", "type": "external" } ], "gene_names_uniprotkb": "Zfp664; Znf664; Zfp664", "gene_names_refseq": "D930038J03Rik; ZFOC1; Zfp664; Znf664", "protein_names_uniprotkb": "Zinc finger protein 664", "protein_names_refseq": "zinc finger protein 664; zinc finger protein ZFOC1", "tax_id": 10090, "disease": "", "pathway": " (mmu:269704); (R-MMU-212436)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4VA44-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60738-1", "uniprot_id": [ { "id": "ZNT1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60738", "type": "external" } ], "mass": 54716.0, "length": 503, "protein_name": "Proton-coupled zinc antiporter SLC30A1", "gene_name": "Slc30a1", "organism": "Mouse", "refseq_name": "proton-coupled zinc antiporter SLC30A1", "refseq_ac": [ { "id": "NP_033605", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033605", "type": "external" } ], "gene_names_uniprotkb": "Slc30a1; Znt1", "gene_names_refseq": "C130040I11Rik; Slc30a1; Znt1", "protein_names_uniprotkb": "Proton-coupled zinc antiporter SLC30A1; Solute carrier family 30 member 1; Zinc transporter 1; ZnT-1", "protein_names_refseq": "proton-coupled zinc antiporter SLC30A1; solute carrier family 30 member 1; zinc transporter 1; znT-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:22782); (R-MMU-435368)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;15451416;15452870;17101726;17242355;19144319;21750661;24602382;25428506;26495903;30084848;34428180;34871934;37828378;39111308;39422023;7882967", "class_list": "", "function": "Zinc ion:proton antiporter that could function at the plasma membrane mediating zinc efflux from cells against its electrochemical gradient protecting them from intracellular zinc accumulation and toxicity (PubMed:39422023, PubMed:39111308). Alternatively, could prevent the transport to the plasma membrane of CACNB2, the L-type calcium channels regulatory subunit, through a yet to be defined mechanism. By modulating the expression of these channels at the plasma membrane, could prevent calcium and zinc influx into cells. By the same mechanism, could also prevent L-type calcium channels-mediated heavy metal influx into cells (PubMed:15451416). In some cells, could also function as a zinc ion:proton antiporter mediating zinc entry into the lumen of cytoplasmic vesicles. In macrophages, can increase zinc ions concentration into the lumen of cytoplasmic vesicles containing engulfed bacteria and could help inactivate them (By similarity). Forms a complex with TMC6/EVER1 and TMC8/EVER2 at the ER membrane of keratynocytes which facilitates zinc uptake into the ER (By similarity). Down-regulates the activity of transcription factors induced by zinc and cytokines (By similarity). Also functions as a copper transporter, facilitating the entry of copper into cells, which is crucial for copper-induced cell death (cuproptosis) (PubMed:39111308). Acts as a Zn(2+)/Ca(2+) exchanger, exporting zinc in exchange for calcium influx (PubMed:34871934)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0046872 metal ion binding;GO:0019855 calcium channel inhibitor activity;GO:0015368 calcium:monoatomic cation antiporter activity;GO:0140826 zinc:proton antiporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0010312 detoxification of zinc ion;GO:0071577 zinc ion transmembrane transport;GO:0090281 negative regulation of calcium ion import;GO:0006829 zinc ion transport;GO:0001701 in utero embryonic development", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q60738-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UDR8-1", "uniprot_id": [ { "id": "YIPF3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UDR8", "type": "external" } ], "mass": 37998.0, "length": 347, "protein_name": "Protein YIPF3", "gene_name": "Yipf3", "organism": "Mouse", "refseq_name": "protein YIPF3 isoform 1", "refseq_ac": [ { "id": "NP_663328", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663328", "type": "external" } ], "gene_names_uniprotkb": "Yipf3; D17Wsu94e; Klip1", "gene_names_refseq": "C6orf109; D17Wsu94e; KLIP1; Yipf3", "protein_names_uniprotkb": "Protein YIPF3; Killer lineage protein 1; YIP1 family member 3", "protein_names_refseq": "YIP1 family member 3; killer lineage protein 1; natural killer cell-specific antigen KLIP1; protein YIPF3 isoform 1; protein YIPF3", "tax_id": 10090, "disease": "", "pathway": " (mmu:28064)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;12490290;21750661;25428506;26495903;26740625;31219806;37828378", "class_list": "", "function": "Involved in the maintenance of the Golgi structure. May play a role in hematopoiesis (By similarity)., [UniProtKB]; Involved in the maintenance of the Golgi structure. May play a role in hematopoiesis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9212, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8C998;Q8K5D1;Q8VCS2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0030133 transport vesicle", "go_biological_process": "GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q3UDR8-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000001000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88799-1", "uniprot_id": [ { "id": "ZAN_MOUSE", "url": "https://www.uniprot.org/uniprot/O88799", "type": "external" } ], "mass": 579913.0, "length": 5376, "protein_name": "Zonadhesin", "gene_name": "Zan", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Zan", "gene_names_refseq": "", "protein_names_uniprotkb": "Zonadhesin", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:22635)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "20173027;21750661;25428506;9126492;9452463", "class_list": "", "function": "Binds in a species-specific manner to the zona pellucida of the egg. May be involved in gamete recognition and/or signaling., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 32, "predicted_n_glycosites": 32, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 32, "binding_glycan_count": 0, "secondary_ac_list": "O08647", "ec_number_list": [], "go_molecular_function": "GO:0050840 extracellular matrix binding;GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0031012 extracellular matrix", "go_biological_process": "GO:0007155 cell adhesion;GO:0007339 binding of sperm to zona pellucida;GO:2000359 regulation of binding of sperm to zona pellucida", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O88799-1", "record_type": "protein", "filter_code": "0000000.1000101.000100.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62005-1", "uniprot_id": [ { "id": "ZP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62005", "type": "external" } ], "mass": 68723.0, "length": 623, "protein_name": "Zona pellucida sperm-binding protein 1", "gene_name": "Zp1", "organism": "Mouse", "refseq_name": "zona pellucida sperm-binding protein 1 precursor", "refseq_ac": [ { "id": "NP_033606", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033606", "type": "external" } ], "gene_names_uniprotkb": "Zp1", "gene_names_refseq": "Zp1", "protein_names_uniprotkb": "Zona pellucida sperm-binding protein 1; Zona pellucida glycoprotein 1; Zp-1", "protein_names_refseq": "zona pellucida sperm-binding protein 1 precursor; zona pellucida sperm-binding protein 1; zp-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:22786); (R-MMU-2534343)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10713085;12799386;21750661;31162612;31219806;7592984;7635043", "class_list": "", "function": "Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida., [UniProtKB]; Influence of mouse defective zona pellucida in folliculogenesis on apoptosis of granulosa cells and developmental competence of oocytesdagger., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 63, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q62016", "ec_number_list": [], "go_molecular_function": "GO:0035804 structural constituent of egg coat;GO:0032190 acrosin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031012 extracellular matrix;GO:0035805 egg coat", "go_biological_process": "GO:0007339 binding of sperm to zona pellucida;GO:0060468 prevention of polyspermy", "synthesized_glycan_count": 0, "hit_score": 7.7, "record_id": "Q62005-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61467-1", "uniprot_id": [ { "id": "ZIC4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61467", "type": "external" } ], "mass": 37437.0, "length": 341, "protein_name": "Zinc finger protein ZIC 4", "gene_name": "Zic4", "organism": "Mouse", "refseq_name": "zinc finger protein ZIC 4 isoform 2", "refseq_ac": [ { "id": "NP_033602", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033602", "type": "external" } ], "gene_names_uniprotkb": "Zic4", "gene_names_refseq": "Zic4", "protein_names_uniprotkb": "Zinc finger protein ZIC 4; Zinc finger protein of the cerebellum 4", "protein_names_refseq": "Zic family member 4 (odd-paired homolog, Drosophila); zinc finger protein ZIC 4 isoform 2; zinc finger protein ZIC 4", "tax_id": 10090, "disease": "Dandy-Walker syndrome (Disease Ontology:DOID:2785); holoprosencephaly (Disease Ontology:DOID:4621)", "pathway": " (mmu:22774)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11180120;15465018;15895369;21750661;8682319", "class_list": "", "function": "Binds to DNA., [UniProtKB, PubMed]; Results describe the molecular properties of Zic4 and Zic5 proteins., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BG91", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0007417 central nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q61467-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3X9G7-1", "uniprot_id": [ { "id": "ZN809_MOUSE", "url": "https://www.uniprot.org/uniprot/G3X9G7", "type": "external" } ], "mass": 46942.0, "length": 402, "protein_name": "Zinc finger protein 809", "gene_name": "Zfp809", "organism": "Mouse", "refseq_name": "zinc finger protein 809 isoform 2", "refseq_ac": [ { "id": "NP_001158096", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158096", "type": "external" } ], "gene_names_uniprotkb": "Zfp809", "gene_names_refseq": "C330026E23; Zfp809", "protein_names_uniprotkb": "Zinc finger protein 809", "protein_names_refseq": "zinc finger protein 809 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:235047)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "19270682;21750661;25737282;26417948;26692479;28115710", "class_list": "", "function": "Data indicate that ZFP809 protein is the key mouse embryonic stem (ES) cell-specific component of the silencing complex for transcriptionally silencing of proviral DNA., [RefSeq, PubMed]; Data suggest that interaction between KAP1 and the KRAB A box of zinc finger protein 809 (ZFP809) is critical in KAP1-dependent control of gene silencing for ZFP809 targets. Publication Status: Online-Only, [RefSeq, PubMed]; Furthermore, the results of the present study indicate that other zinc fingers, which were not directly involved in binding to MLV PBS, may function in potentiating binding and stable protein expression., [RefSeq, PubMed]; Transcription factor specifically required to repress retrotransposons in embryonic stem cells. Recognizes and binds retroviral DNA sequences from a large subset of mammalian retroviruses and retroelements and repress their expression by recruiting a repressive complex containing TRIM28/KAP1 (PubMed:19270682)., [UniProtKB, PubMed]; ZFP809 appears to be a stem-cell-specific retroviral restriction factor, and therefore may constitute a new component of the intrinsic immune system of stem cells, [RefSeq, PubMed]; ZFP809 evolved to recognize foreign DNA and establish histone modification-based epigenetic silencing of endogenous retroviruses., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4KL58;Q8BIJ2", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045087 innate immune response;GO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "G3X9G7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PGE4-1", "uniprot_id": [ { "id": "ZF316_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PGE4", "type": "external" } ], "mass": 110812.0, "length": 1016, "protein_name": "Zinc finger protein 316", "gene_name": "Zfp316; Znf316", "organism": "Mouse", "refseq_name": "zinc finger protein 316", "refseq_ac": [ { "id": "NP_059495", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059495", "type": "external" } ], "gene_names_uniprotkb": "Zfp316; Znf316; Zfp316", "gene_names_refseq": "Emzf1; Mzf3; Zfp316; Znf316", "protein_names_uniprotkb": "Zinc finger protein 316", "protein_names_refseq": "kruppel-related zinc finger protein; transcription factor MZF-3; zinc finger protein 316", "tax_id": 10090, "disease": "", "pathway": " (mmu:54201)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6PGE4-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88967-1", "uniprot_id": [ { "id": "YMEL1_MOUSE", "url": "https://www.uniprot.org/uniprot/O88967", "type": "external" } ], "mass": 80028.0, "length": 715, "protein_name": "ATP-dependent zinc metalloprotease YME1L1", "gene_name": "Yme1l1", "organism": "Mouse", "refseq_name": "ATP-dependent zinc metalloprotease YME1L1", "refseq_ac": [ { "id": "NP_038799", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038799", "type": "external" } ], "gene_names_uniprotkb": "Yme1l1", "gene_names_refseq": "FtsH1; Ftsh; Yme1l1", "protein_names_uniprotkb": "ATP-dependent zinc metalloprotease YME1L1; 3.4.24.-; 3.6.-.-; ATP-dependent metalloprotease FtsH1; YME1-like protein 1", "protein_names_refseq": "ATP-dependent metalloprotease FtsH1; ATP-dependent zinc metalloprotease YME1L1; YME1-like protein 1", "tax_id": 10090, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); optic atrophy 11 (Disease Ontology:DOID:0111436); dilated cardiomyopathy (Disease Ontology:DOID:12930); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (mmu:27377); (R-MMU-8949664); (R-MMU-9840373)", "pathway_count": 3, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;17709429;24616225;24703695;25428506;25605945;26393574;26785494;27495975;30084848;30779550;31219806;31599954;33237841;34428180;35172139;36210013;36433732;37063426;37816711", "class_list": "", "function": "ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region (PubMed:17709429, PubMed:24616225, PubMed:24703695, PubMed:26785494, PubMed:27495975, PubMed:33237841). Plays an important role in regulating mitochondrial morphology and function by cleaving OPA1 at position S2, giving rise to a form of OPA1 that promotes maintenance of normal mitochondrial structure and mitochondrial protein metabolism (PubMed:17709429, PubMed:24616225, PubMed:24703695, PubMed:26785494, PubMed:27495975, PubMed:33237841, PubMed:37816711). Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins (By similarity). Required to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1) (By similarity). Involved in the mitochondrial adaptation in response to various signals, such as stress or developmental cues, by mediating degradation of mitochondrial proteins to rewire the mitochondrial proteome (PubMed:35172139). Catalyzes degradation of mitochondrial proteins, such as translocases, lipid transfer proteins and metabolic enzymes in response to nutrient starvation in order to limit mitochondrial biogenesis: mechanistically, YME1L1 is activated by decreased phosphatidylethanolamine levels caused by LPIN1 activity in response to mTORC1 inhibition (By similarity). Acts as a regulator of adult neural stem cell self-renewal by promoting mitochondrial proteome rewiring, preserving neural stem and progenitor cells self-renewal (PubMed:35172139). Required for normal, constitutive degradation of PRELID1 (PubMed:26785494). Catalyzes the degradation of OMA1 in response to membrane depolarization (By similarity). Mediates degradation of TIMM17A downstream of the integrated stress response (ISR) (By similarity). Catalyzes degradation of MICU1 when MICU1 is not assembled via an interchain disulfide (By similarity). Cleaves STARD7 mitochondrial targeting sequence (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Constitutive OPA1 cleavage by YME1L and OMA1 at two distinct sites leads to the accumulation of both long and short forms of OPA1 and maintains mitochondrial fusion., [RefSeq, PubMed]; Data suggest that in a mouse model of neonatal hypoxic-ischemic brain injury, the expression of mitochondrial shaping proteins, such as OPA1 and Yme1L, are altered; in vitro and in vivo, OPA1 is cleaved to shorter forms and Yme1L expression is reduced. Publication Status: Online-Only, [RefSeq, PubMed]; Sirt3 mitigates LPS-induced mitochondrial damage in renal tubular epithelial cells by deacetylating YME1L1., [RefSeq, PubMed]; The mitochondrial protein YME1 Like 1 is important for non-small cell lung cancer cell growth. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 4, "disease_count": 4, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q7TNN5", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.105", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.105", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0004176 ATP-dependent peptidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0016604 nuclear body", "go_biological_process": "GO:0010636 positive regulation of mitochondrial fusion;GO:0008283 cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0007005 mitochondrion organization;GO:0009267 cellular response to starvation", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "O88967-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10751-1", "uniprot_id": [ { "id": "ZFP11_MOUSE", "url": "https://www.uniprot.org/uniprot/P10751", "type": "external" } ], "mass": 75605.0, "length": 647, "protein_name": "Zinc finger protein 11", "gene_name": "Zfp11", "organism": "Mouse", "refseq_name": "zinc finger protein 11", "refseq_ac": [ { "id": "NP_766050", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766050", "type": "external" } ], "gene_names_uniprotkb": "Zfp11; Krox-6.1a; Krox-6.1b", "gene_names_refseq": "6720465D24; Krox-6; Zfp-11; Zfp11", "protein_names_uniprotkb": "Zinc finger protein 11; Zfp-11; Zinc finger protein Krox-6.1A/6.1B+/6.1B-", "protein_names_refseq": "protein Krox-6.1A/6.1B+/6.1B-; zinc finger protein 11; zinc finger protein Krox-6.1A/6.1B+/6.1B-", "tax_id": 10090, "disease": "", "pathway": " (mmu:22648)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "2452975;34428180;35820727", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RTF0;P10752;P10753;Q505E4;Q6PDR5;Q8BSI2;Q8C3R5", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0032502 developmental process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P10751-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10755-1", "uniprot_id": [ { "id": "ZFP14_MOUSE", "url": "https://www.uniprot.org/uniprot/P10755", "type": "external" } ], "mass": 59060.0, "length": 501, "protein_name": "Zinc finger protein 14", "gene_name": "Zfp14", "organism": "Mouse", "refseq_name": "zinc finger protein 14", "refseq_ac": [ { "id": "NP_035878", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035878", "type": "external" } ], "gene_names_uniprotkb": "Zfp14; Kiaa1559; Krox-9; Zfp-14", "gene_names_refseq": "4732429I09Rik; Krox-9; Zfp-14; Zfp14; mKIAA1559", "protein_names_uniprotkb": "Zinc finger protein 14; Zfp-14; Zinc finger protein Krox-9", "protein_names_refseq": "zinc finger protein 14; zinc finger protein Krox-9", "tax_id": 10090, "disease": "", "pathway": " (mmu:243906); (R-MMU-212436)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "2452975;36349645", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB]; Poly zinc finger protein ZFP14 suppresses lymphomagenesis and abnormal inflammatory response via the HOXA gene cluster., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5DTW6;Q8BFZ5", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0001835 blastocyst hatching", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P10755-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15620-1", "uniprot_id": [ { "id": "ZN271_MOUSE", "url": "https://www.uniprot.org/uniprot/P15620", "type": "external" } ], "mass": 67036.0, "length": 580, "protein_name": "Zinc finger protein 271", "gene_name": "Znf271", "organism": "Mouse", "refseq_name": "zinc finger protein 271", "refseq_ac": [ { "id": "NP_035885", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035885", "type": "external" } ], "gene_names_uniprotkb": "Znf271; Zfp-35; Zfp35", "gene_names_refseq": "Zfp-35; Zfp35; Znf271; mszf13; mszf20-1; mszf28; mszf68", "protein_names_uniprotkb": "Zinc finger protein 271; Zfp-35; Zinc finger protein 35", "protein_names_refseq": "zinc finger protein 271", "tax_id": 10090, "disease": "", "pathway": " (mmu:22694); (R-MMU-212436)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "19783676;2104800;2249852", "class_list": "", "function": "May act to control gene activity during the pachytene stage of meiotic prophase. May function as a transcription activator., [UniProtKB]; Zfp35 may control Th2-dependent diseases, such as allergic asthma., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0045596 negative regulation of cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P15620-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16373-1", "uniprot_id": [ { "id": "ZFP59_MOUSE", "url": "https://www.uniprot.org/uniprot/P16373", "type": "external" } ], "mass": 74861.0, "length": 653, "protein_name": "Zinc finger protein 59", "gene_name": "Zfp59", "organism": "Mouse", "refseq_name": "zinc finger protein 59", "refseq_ac": [ { "id": "NP_035892", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035892", "type": "external" } ], "gene_names_uniprotkb": "Zfp59; Mfg2", "gene_names_refseq": "Mfg-2; Mfg2; Zfp59", "protein_names_uniprotkb": "Zinc finger protein 59; Zfp-59; Zinc finger protein Mfg-2", "protein_names_refseq": "zfp-59; zinc finger protein 59; zinc finger protein Mfg-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:22717)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "23386199;2512579;25609838;8547218", "class_list": "", "function": "May have a role during differentiation processes., [UniProtKB, PubMed]; The Krueppel-associated box (KRAB) is a domain of around 75 amino acids found in the N-terminal portion of about one third of eukaryotic Krueppel-type C2H2 zinc finger proteins (ZFPs). The KRAB domain functions as a transcriptional repressor when tethered to the template DNA by a DNA-binding domain. Although the function of KRAB-ZFPs is largely unknown, they appear to play important roles during cell differentiation and development. This gene encodes a protein belonging to the Krueppel family of C2H2-type zinc finger proteins and has been shown to accumulate in the nuclei of mature sperm in association with the nuclear matrix. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F8VPX4;Q61849", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P16373-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P59268-1", "uniprot_id": [ { "id": "ZDHC9_MOUSE", "url": "https://www.uniprot.org/uniprot/P59268", "type": "external" } ], "mass": 40940.0, "length": 364, "protein_name": "Palmitoyltransferase ZDHHC9", "gene_name": "Zdhhc9", "organism": "Mouse", "refseq_name": "palmitoyltransferase ZDHHC9", "refseq_ac": [ { "id": "NP_766053", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766053", "type": "external" } ], "gene_names_uniprotkb": "Zdhhc9", "gene_names_refseq": "6430508G22; 9530098M12Rik; Zdhhc9", "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC9; 2.3.1.225; DHHC-9; DHHC9; Zinc finger DHHC domain-containing protein 9", "protein_names_refseq": "DHHC-9; DHHC9; palmitoyltransferase ZDHHC9; zinc finger DHHC domain-containing protein 9", "tax_id": 10090, "disease": "syndromic X-linked intellectual disability Raymond type (Disease Ontology:DOID:0060824)", "pathway": " (mmu:208884); (R-MMU-9648002)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "25428506;29944857;30084848;31747610;34428180;38530158", "class_list": "", "function": "Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates, such as ADRB2, GSDMD, HRAS, NRAS and CGAS (PubMed:38530158). The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS (By similarity). May have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein-coupled receptor signaling (By similarity). Acts as a regulator of innate immunity by catalyzing palmitoylation of CGAS, thereby promoting CGAS homodimerization and cyclic GMP-AMP synthase activity (By similarity). Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD (PubMed:38530158)., [UniProtKB, UniProtKB, PubMed]; The X-Linked Intellectual Disability Gene Zdhhc9 Is Essential for Dendrite Outgrowth and Inhibitory Synapse Formation., [RefSeq, PubMed]; This study highlights a key role for zDHHC9 in brain development and behaviour, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5BL19", "ec_number_list": [ { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "6.3.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.1.2", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0019706 protein-cysteine S-palmitoyltransferase activity;GO:0016409 palmitoyltransferase activity;GO:0043849 Ras palmitoyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0043687 post-translational protein modification;GO:0006612 protein targeting to membrane;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0036503 ERAD pathway;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P59268-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08EN7-1", "uniprot_id": [ { "id": "ZCPW2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q08EN7", "type": "external" } ], "mass": 37519.0, "length": 331, "protein_name": "Zinc finger CW-type PWWP domain protein 2 homolog", "gene_name": "Zcwpw2", "organism": "Mouse", "refseq_name": "zinc finger CW-type PWWP domain protein 2 homolog", "refseq_ac": [ { "id": "NP_001365395", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001365395", "type": "external" } ], "gene_names_uniprotkb": "Zcwpw2", "gene_names_refseq": "4930430K04Rik; Zcwpw2", "protein_names_uniprotkb": "Zinc finger CW-type PWWP domain protein 2 homolog", "protein_names_refseq": "zinc finger CW-type PWWP domain protein 2 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:100039681)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (By similarity). The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A5F8MP94", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0140002 histone H3K4me3 reader activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q08EN7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VAW7-1", "uniprot_id": [ { "id": "ZN112_MOUSE", "url": "https://www.uniprot.org/uniprot/Q0VAW7", "type": "external" } ], "mass": 98510.0, "length": 879, "protein_name": "Zinc finger protein 112", "gene_name": "Zfp112; Znf112", "organism": "Mouse", "refseq_name": "zinc finger protein 112 isoform 1", "refseq_ac": [ { "id": "NP_067282", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067282", "type": "external" } ], "gene_names_uniprotkb": "Zfp112; Znf112; Zfp112", "gene_names_refseq": "Zfp112; Znf112; Znf228", "protein_names_uniprotkb": "Zinc finger protein 112; Zfp-112", "protein_names_refseq": "zfp-112; zinc finger protein 112 homolog; zinc finger protein 112 isoform 1; zinc finger protein 112; zinc finger protein ZFP112", "tax_id": 10090, "disease": "", "pathway": " (mmu:57745); (R-MMU-212436)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "12743021;21750661;31219806", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3Z7D1;E9QP25;Q9R163", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000976 transcription cis-regulatory region binding;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0001650 fibrillar center", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q0VAW7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VDT2-1", "uniprot_id": [ { "id": "ZN367_MOUSE", "url": "https://www.uniprot.org/uniprot/Q0VDT2", "type": "external" } ], "mass": 37453.0, "length": 340, "protein_name": "Zinc finger protein 367", "gene_name": "Znf367", "organism": "Mouse", "refseq_name": "zinc finger protein 367 isoform 1", "refseq_ac": [ { "id": "NP_780703", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780703", "type": "external" } ], "gene_names_uniprotkb": "Znf367; Zff29; Zfp367", "gene_names_refseq": "8030486J21Rik; ZFF29a; ZFF29b; Zfp367; Znf367", "protein_names_uniprotkb": "Zinc finger protein 367; C2H2 zinc finger protein ZFF29", "protein_names_refseq": "C2H2 zinc finger protein ZFF29; zinc finger protein 367 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:238673)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15344908;21183079", "class_list": "", "function": "Transcriptional activator. Isoform 1 may be involved in transcriptional activation of erythroid genes (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B1B191;B1B192;Q8BH90;Q8BI44;Q8BI88", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q0VDT2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1WG82-1", "uniprot_id": [ { "id": "ZGLP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q1WG82", "type": "external" } ], "mass": 29107.0, "length": 266, "protein_name": "GATA-type zinc finger protein 1", "gene_name": "Zglp1", "organism": "Mouse", "refseq_name": "GATA-type zinc finger protein 1", "refseq_ac": [ { "id": "NP_001096638", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096638", "type": "external" } ], "gene_names_uniprotkb": "Zglp1; Glp1", "gene_names_refseq": "Glp1; Zglp1", "protein_names_uniprotkb": "GATA-type zinc finger protein 1; GATA-like protein 1; GLP-1", "protein_names_refseq": "GATA-like 1; GATA-like protein 1; GATA-type zinc finger protein 1; GLP-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:100009600)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "16982049;21123517;22384126;24356748;25976560;29056294;31219806;32054698", "class_list": "", "function": "Data demonstrate an increase in number of pro-alpha cells and activation of the intra-islet GLP-1 system comprise a self-defense mechanism for enhancing beta cell survival to combat lipid overload, which is in part mediated by oxidative stress and inflammation., [RefSeq, PubMed]; Data identify GLP-1 as a critical nuclear repressor in somatic cells of the gonad that is required for germ cell development, and highlight the importance of somatic-germ cell interactions in the regulation of this critical process, [RefSeq, PubMed]; Findings indicate an essential role for VAMP2 in GLP-1 exocytosis from the GLUTag L cell in response to a variety of established secretagogues., [RefSeq, PubMed]; GLP-1 and analogues may provide neuroprotective actions in ALS, [RefSeq, PubMed]; Loss of GLP-1 is associated with germ cell development during embryonic oogenesis., [RefSeq, PubMed]; Study provides a comprehensive multi-level (circuit, synaptic, and molecular) explanation of how food intake behavior and body weight are regulated by endogenous central GLP-1., [RefSeq, PubMed]; This study shows that ZGLP1, a conserved transcriptional regulator with GATA-like zinc fingers, determines the oogenic fate in mice., [RefSeq, PubMed]; Transcriptional regulator that plays a key role in germ cell development (PubMed:16982049, PubMed:21123517, PubMed:32054698). Determines the oogenic fate by activating key genes for the oogenic program and meiotic prophase entry (PubMed:32054698). Acts downstream of bone morphogenetic protein (BMP) by regulating expression of genes required for the oogenic programs, which are repressed by Polycomb activities in sexually uncommitted germ cells (PubMed:32054698). Regulates expression of STRA8, a central downstream effector for the meiotic program (PubMed:32054698). Acts independently of retinoic acid (RA) (PubMed:32054698). In males, not required for germ-cell sex determination, but required to allow the spermatogonia to efficiently accomplish the meiotic prophase (PubMed:32054698)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q1WG82-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TTI8-1", "uniprot_id": [ { "id": "TEX52_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TTI8", "type": "external" } ], "mass": 35370.0, "length": 308, "protein_name": "Testis-expressed protein 52", "gene_name": "Tex52", "organism": "Mouse", "refseq_name": "testis-expressed protein 52", "refseq_ac": [ { "id": "NP_081973", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081973", "type": "external" } ], "gene_names_uniprotkb": "Tex52", "gene_names_refseq": "4933413G19Rik; Tex52", "protein_names_uniprotkb": "Testis-expressed protein 52", "protein_names_refseq": "testis-expressed protein 52", "tax_id": 10090, "disease": "", "pathway": " (mmu:71149)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D448", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3TTI8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TYL0-1", "uniprot_id": [ { "id": "IQAK1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TYL0", "type": "external" } ], "mass": 60994.0, "length": 540, "protein_name": "IQ motif and ankyrin repeat domain-containing protein 1", "gene_name": "Iqank1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Iqank1; K230010J24Rik", "gene_names_refseq": "", "protein_names_uniprotkb": "IQ motif and ankyrin repeat domain-containing protein 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:432964)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A140LHX0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3TYL0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q505G8-1", "uniprot_id": [ { "id": "ZN827_MOUSE", "url": "https://www.uniprot.org/uniprot/Q505G8", "type": "external" } ], "mass": 118536.0, "length": 1078, "protein_name": "Zinc finger protein 827", "gene_name": "Zfp827; Znf827", "organism": "Mouse", "refseq_name": "zinc finger protein 827 isoform 2", "refseq_ac": [ { "id": "NP_001281208", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001281208", "type": "external" } ], "gene_names_uniprotkb": "Zfp827; Znf827; Zfp827", "gene_names_refseq": "2810449M09Rik; D630040G17Rik; Zfp827; Znf827", "protein_names_uniprotkb": "Zinc finger protein 827", "protein_names_refseq": "zinc finger protein 827 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:622675); (R-MMU-9940951)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "As part of a ribonucleoprotein complex composed at least of HNRNPK, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation. Could also recruit the nucleosome remodeling and histone deacetylase/NuRD complex to telomeric regions of chromosomes to regulate chromatin remodeling as part of telomere maintenance., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RXD8;Q5M7B0", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding;GO:0120325 NuRD complex binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:1990904 ribonucleoprotein complex;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0000723 telomere maintenance", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q505G8-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ISE2-1", "uniprot_id": [ { "id": "Z36L3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5ISE2", "type": "external" } ], "mass": 72346.0, "length": 725, "protein_name": "mRNA decay activator protein ZFP36L3", "gene_name": "Zfp36l3", "organism": "Mouse", "refseq_name": "mRNA decay activator protein ZFP36L3", "refseq_ac": [ { "id": "NP_001009549", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009549", "type": "external" } ], "gene_names_uniprotkb": "Zfp36l3", "gene_names_refseq": "Zfp36l3", "protein_names_uniprotkb": "mRNA decay activator protein ZFP36L3; Zinc finger protein 36, C3H1 type-like 3; zinc finger protein 36-like 3", "protein_names_refseq": "mRNA decay activator protein ZFP36L3; zinc finger protein 36, C3H1 type-like 3; zinc finger protein 36-like 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:333473)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15814898;18367448;25428506;26493225;26952984", "class_list": "", "function": "Mice deficient in ZFP36L3 exhibited decreased neonatal survival rates, but no apparent morphological changes in the placenta or surviving offspring., [RefSeq, PubMed]; Placenta-specific zinc-finger RNA-binding protein that destabilizes cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:15814898, PubMed:26952984). Binds to the 3'-UTR ARE of placental target mRNAs, such as TNF, HBEGF and LIPG (PubMed:15814898, PubMed:18367448, PubMed:26952984). Involved in placental expression of many genes important for normal placental physiology (PubMed:26952984)., [UniProtKB, PubMed, PubMed, PubMed]; ZFP36L3 is a 'full-time' cytosolic protein, rather than a nucleocytoplasmic shuttling protein, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0035925 mRNA 3'-UTR AU-rich region binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q5ISE2-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61116-1", "uniprot_id": [ { "id": "ZN235_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61116", "type": "external" } ], "mass": 73012.0, "length": 645, "protein_name": "Zinc finger protein 235", "gene_name": "Znf235", "organism": "Mouse", "refseq_name": "zinc finger protein 235 isoform 2", "refseq_ac": [ { "id": "NP_033593", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033593", "type": "external" } ], "gene_names_uniprotkb": "Znf235; Zfp93", "gene_names_refseq": "Zfp93; Znf235", "protein_names_uniprotkb": "Zinc finger protein 235; Zfp-93; Zinc finger protein 93", "protein_names_refseq": "zfp-93; zinc finger protein 235 isoform 2; zinc finger protein 235", "tax_id": 10090, "disease": "", "pathway": " (mmu:22755)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8617494", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB]; Zfp93 zinc finger protein 93, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UKA3;Q8CE70", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q61116-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q69ZB8-1", "uniprot_id": [ { "id": "ZCHC2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q69ZB8", "type": "external" } ], "mass": 124517.0, "length": 1166, "protein_name": "Zinc finger CCHC domain-containing protein 2", "gene_name": "Zcchc2", "organism": "Mouse", "refseq_name": "zinc finger CCHC domain-containing protein 2 isoform B", "refseq_ac": [ { "id": "NP_001116147", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116147", "type": "external" } ], "gene_names_uniprotkb": "Zcchc2; Kiaa1744", "gene_names_refseq": "9930114B20Rik; Zcchc2", "protein_names_uniprotkb": "Zinc finger CCHC domain-containing protein 2", "protein_names_refseq": "zinc finger CCHC domain-containing protein 2 isoform B; zinc finger CCHC domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:227449)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;25428506;31219806;34428180", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7TNF1;Q8CB08", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q69ZB8-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DI92-1", "uniprot_id": [ { "id": "ZSWM9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6DI92", "type": "external" } ], "mass": 50467.0, "length": 447, "protein_name": "Uncharacterized protein ZSWIM9", "gene_name": "Zswim9", "organism": "Mouse", "refseq_name": "uncharacterized protein ZSWIM9", "refseq_ac": [ { "id": "NP_796286", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796286", "type": "external" } ], "gene_names_uniprotkb": "Zswim9; 6330408A02Rik", "gene_names_refseq": "6330408A02Rik; Zswim9", "protein_names_uniprotkb": "Uncharacterized protein ZSWIM9", "protein_names_refseq": "uncharacterized protein C19orf68 homolog; uncharacterized protein ZSWIM9", "tax_id": 10090, "disease": "", "pathway": " (mmu:321008)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;31219806", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TRL3;Q3V0S9;Q9D3B2", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "", "go_biological_process": "GO:0002244 hematopoietic progenitor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6DI92-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NS86-1", "uniprot_id": [ { "id": "ZN366_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6NS86", "type": "external" } ], "mass": 84826.0, "length": 746, "protein_name": "Zinc finger protein 366", "gene_name": "Znf366", "organism": "Mouse", "refseq_name": "zinc finger protein 366", "refseq_ac": [ { "id": "NP_001004149", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004149", "type": "external" } ], "gene_names_uniprotkb": "Znf366; Zfp366", "gene_names_refseq": "DC-SCRIPT; Zfp366; Znf366", "protein_names_uniprotkb": "Zinc finger protein 366; DC-SCRIPT; Dendritic cell-specific transcript protein", "protein_names_refseq": "dendritic cell-specific transcript protein; zinc finger protein 366", "tax_id": 10090, "disease": "DiGeorge syndrome (Disease Ontology:DOID:11198)", "pathway": " (mmu:238803)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16522745;30611612;31265831;32422143;33811060;34428180", "class_list": "", "function": "DC-SCRIPT affects mammary organoids branching morphogenesis by modulating the FGFR1-pERK signaling axis., [RefSeq, PubMed]; Findings show that zinc finger protein 366 (DC-SCRIPT) deficiency delays mammary gland morphogenesis in vivo and in vitro and indicate DC-SCRIPT as a modulator of mammary gland development., [RefSeq, PubMed]; Has transcriptional repression activity. Acts as a corepressor of ESR1; the function seems to involve CTBP1 and histone deacetylases., [UniProtKB, UniProtKB]; Taken together, these data show that DC-SCRIPT is well-conserved in evolution and that the mouse homologue is more than 80% homologous to the human protein.(DC-SCRIPT protein, mouse), [RefSeq, PubMed]; This study shows that PU.1 promotes conventional dendritic cell identity and function via induction of transcriptional regulator DC-SCRIPT, [RefSeq, PubMed]; Type 1 conventional dendritic cell fate and function are controlled by DC-SCRIPT., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0030331 nuclear estrogen receptor binding", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0043627 response to estrogen;GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6NS86-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P3Y5-1", "uniprot_id": [ { "id": "Z280C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P3Y5", "type": "external" } ], "mass": 83146.0, "length": 742, "protein_name": "Zinc finger protein 280C", "gene_name": "Znf280c", "organism": "Mouse", "refseq_name": "zinc finger protein 280C isoform 1", "refseq_ac": [ { "id": "NP_001160120", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160120", "type": "external" } ], "gene_names_uniprotkb": "Znf280c; Kiaa1584; Suhw3; Zfp280c", "gene_names_refseq": "Suhw3; Zfp280c; Zfp633; Znf280c; mKIAA1584", "protein_names_uniprotkb": "Zinc finger protein 280C; Suppressor of hairy wing homolog 3", "protein_names_refseq": "suppressor of hairy wing homolog 3; zinc finger protein 280C isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:208968)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "25428506;31219806;34428180;35820727", "class_list": "", "function": "May function as a transcription factor., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AU28;B1AU29;Q6ZPM2;Q8K145", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6P3Y5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P5C7-1", "uniprot_id": [ { "id": "ZN728_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P5C7", "type": "external" } ], "mass": 86422.0, "length": 752, "protein_name": "Zinc finger protein 728", "gene_name": "Zfp458; Znf728", "organism": "Mouse", "refseq_name": "zinc finger protein 728", "refseq_ac": [ { "id": "NP_001001152", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001152", "type": "external" } ], "gene_names_uniprotkb": "Zfp458; Znf728; Zfp458", "gene_names_refseq": "Gm33446; Rslcan-7; Zfp458; Znf728; mszf59-2", "protein_names_uniprotkb": "Zinc finger protein 728", "protein_names_refseq": "zinc finger protein 728", "tax_id": 10090, "disease": "", "pathway": " (mmu:238690); (R-MMU-212436)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21750661;25605945", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6P5C7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TSI0-1", "uniprot_id": [ { "id": "ZNF12_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TSI0", "type": "external" } ], "mass": 78617.0, "length": 686, "protein_name": "Zinc finger protein 12", "gene_name": "Zfp12; Znf12", "organism": "Mouse", "refseq_name": "zinc finger protein 12 isoform 1", "refseq_ac": [ { "id": "NP_001276518", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276518", "type": "external" } ], "gene_names_uniprotkb": "Zfp12; Znf12; Zfp12", "gene_names_refseq": "C530015C18; Krox-7; Zfp-12; Zfp12; Znf12", "protein_names_uniprotkb": "Zinc finger protein 12", "protein_names_refseq": "zinc finger protein 12 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:231866); (R-MMU-212436)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Transcriptional repressor which suppresses activation protein 1 (AP-1)- and serum response element (SRE)-mediated transcriptional activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C7Q7", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TSI0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UVU3-1", "uniprot_id": [ { "id": "ZNT10_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UVU3", "type": "external" } ], "mass": 50911.0, "length": 470, "protein_name": "Calcium/manganese antiporter SLC30A10", "gene_name": "Slc30a10", "organism": "Mouse", "refseq_name": "calcium/manganese antiporter SLC30A10", "refseq_ac": [ { "id": "NP_001028458", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028458", "type": "external" } ], "gene_names_uniprotkb": "Slc30a10", "gene_names_refseq": "E130106K10Rik; Gm212; Slc30a10", "protein_names_uniprotkb": "Calcium/manganese antiporter SLC30A10; Solute carrier family 30 member 10", "protein_names_refseq": "calcium/manganese antiporter SLC30A10; zinc transporter 10; znT-10", "tax_id": 10090, "disease": "hypermanganesemia with dystonia 1 (Disease Ontology:DOID:0080536)", "pathway": " (mmu:226781); (R-MMU-425410)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "17242355;21750661;28461334;28688763;28860195;30559290;34428180;38285613;38336290;38652538;38866719", "class_list": "", "function": "AAV-mediated hepatic expression of SLC30A10 and the Thr95Ile variant attenuates manganese excess and other phenotypes in Slc30a10-deficient mice., [RefSeq, PubMed]; Calcium:manganese antiporter of the plasma membrane mediating the efflux of intracellular manganese coupled to an active extracellular calcium exchange. Required for intracellular manganese homeostasis, an essential cation for the function of several enzymes, including some crucially important for the metabolism of neurotransmitters and other neuronal metabolic pathways. Manganese can also be cytotoxic and induce oxidative stress, mitochondrial dysfunction and apoptosis (PubMed:28461334). Could also have an intracellular zinc ion transporter activity, directly regulating intracellular zinc ion homeostasis and more indirectly various signaling pathway and biological processes (By similarity)., [UniProtKB, UniProtKB, PubMed]; Discovery highlights the importance of determining the role of thyroid dysfunction in the onset and progression of manganese-induced disease and identifies Slc30a10 knock-out mice as a new model for studying thyroid biology., [RefSeq, PubMed]; Elevated thyroid manganese reduces thyroid iodine to induce hypothyroidism in mice, but not rats, lacking SLC30A10 transporter., [RefSeq, PubMed]; Hepatic HIF2 is a key determinant of manganese excess and polycythemia in SLC30A10 deficiency. Publication Status: Online-Only, [RefSeq, PubMed]; Loss of SLC30A10 manganese transporter alters expression of neurotransmission genes and activates hypoxia-inducible factor signaling in mice., [RefSeq, PubMed]; SLC30A10 has a protective role in 1-methyl-4-phenylpyridinium-induced toxicity via PERK-ATF4 pathway., [RefSeq, PubMed]; The hypothyroidism phenotype of Slc30a10 single knockouts is induced by elevated thyroid manganese, which blocks thyroxine production. These findings provide new insights into the mechanisms of manganese detoxification and manganese-induced thyroid dysfunction., [RefSeq, PubMed]; When manganese levels increase, activity of SLC30A10 in the brain protects against neurotoxicity, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q32NY2", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0005384 manganese ion transmembrane transporter activity;GO:0140983 calcium:manganese antiporter activity;GO:0008324 monoatomic cation transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0010312 detoxification of zinc ion;GO:1904385 cellular response to angiotensin;GO:0071577 zinc ion transmembrane transport;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0007173 epidermal growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q3UVU3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JGK2-1", "uniprot_id": [ { "id": "A0A0G2JGK2_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A0G2JGK2", "type": "external" } ], "mass": 12957.0, "length": 117, "protein_name": "Immunoglobulin heavy variable V1-74", "gene_name": "Ighv1-74", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ighv1-74", "gene_names_refseq": "", "protein_names_uniprotkb": "Immunoglobulin heavy variable V1-74", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2JGK2-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1Y7VIZ1-1", "uniprot_id": [ { "id": "A0A1Y7VIZ1_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A1Y7VIZ1", "type": "external" } ], "mass": 54984.0, "length": 466, "protein_name": "Pluripotency associated transcript 25", "gene_name": "Platr25", "organism": "Mouse", "refseq_name": "zinc finger protein 782 isoform X6", "refseq_ac": [ { "id": "XP_054875605", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_054875605", "type": "external" } ], "gene_names_uniprotkb": "Platr25", "gene_names_refseq": "Platr25", "protein_names_uniprotkb": "Pluripotency associated transcript 25", "protein_names_refseq": "zinc finger protein 782 isoform X6", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003677 DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A1Y7VIZ1-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A286YEC0-1", "uniprot_id": [ { "id": "CIROP_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A286YEC0", "type": "external" } ], "mass": 76711.0, "length": 699, "protein_name": "Ciliated left-right organizer metallopeptidase", "gene_name": "Cirop", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cirop; Gm29776", "gene_names_refseq": "", "protein_names_uniprotkb": "Ciliated left-right organizer metallopeptidase; 3.4.24.-; Leishmanolysin-like peptidase 2", "protein_names_refseq": "", "tax_id": 10090, "disease": "visceral heterotaxy 12 (Disease Ontology:DOID:0051026)", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "21750661;34903892", "class_list": "", "function": "Putative metalloproteinase that plays a role in left-right patterning process., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0007155 cell adhesion;GO:0061966 establishment of left/right asymmetry", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A286YEC0-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z3I0-1", "uniprot_id": [ { "id": "CD20B_MOUSE", "url": "https://www.uniprot.org/uniprot/D3Z3I0", "type": "external" } ], "mass": 57442.0, "length": 519, "protein_name": "Cell division cycle protein 20 homolog B", "gene_name": "Cdc20b", "organism": "Mouse", "refseq_name": "cell division cycle protein 20 homolog B", "refseq_ac": [ { "id": "NP_001268416", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001268416", "type": "external" } ], "gene_names_uniprotkb": "Cdc20b", "gene_names_refseq": "Cdc20b; EG238896; EG622422", "protein_names_uniprotkb": "Cell division cycle protein 20 homolog B", "protein_names_refseq": "cell division cycle 20 homolog B; cell division cycle protein 20 homolog B", "tax_id": 10090, "disease": "", "pathway": " (mmu:238896)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;30405130;30779550", "class_list": "", "function": "CDC20B protein associates to deuterosomes and is required for centriole release and subsequent cilia production. Publication Status: Online-Only, [RefSeq, PubMed]; Protein regulator of centriole-deuterosome disengagement and subsequently participates in the ciliogenesis in multiciliated cells (MCCs)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0010997 anaphase-promoting complex binding;GO:1990757 ubiquitin ligase activator activity;GO:0097027 ubiquitin-protein transferase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005680 anaphase-promoting complex;GO:0098536 deuterosome", "go_biological_process": "GO:0031145 anaphase-promoting complex-dependent catabolic process;GO:1905786 positive regulation of anaphase-promoting complex-dependent catabolic process;GO:0097742 de novo centriole assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D3Z3I0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PWL0-1", "uniprot_id": [ { "id": "E9PWL0_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PWL0", "type": "external" } ], "mass": 57527.0, "length": 497, "protein_name": "Tripartite motif-containing 30D", "gene_name": "Trim30d", "organism": "Mouse", "refseq_name": "tripartite motif-containing 79 isoform 1", "refseq_ac": [ { "id": "NP_954597", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_954597", "type": "external" } ], "gene_names_uniprotkb": "Trim30d", "gene_names_refseq": "TRIM30-3; Trim30d; Trim79", "protein_names_uniprotkb": "Tripartite motif-containing 30D", "protein_names_refseq": "tripartite motif-containing 79 isoform 1; tripartite motif-containing 79", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "21750661;21925107;31599954", "class_list": "", "function": "TRIM79 restricts tick-borne encephalitis virus replication by degradation the NS5 protein, an RNA-dependent RNA polymerase essential for virus replication., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0019901 protein kinase binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000932 P-body", "go_biological_process": "GO:0046596 regulation of viral entry into host cell;GO:0044790 suppression of viral release by host;GO:0043410 positive regulation of MAPK cascade;GO:0045087 innate immune response;GO:0032880 regulation of protein localization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "E9PWL0-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80V23-1", "uniprot_id": [ { "id": "ZNF32_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80V23", "type": "external" } ], "mass": 30773.0, "length": 272, "protein_name": "Zinc finger protein 32", "gene_name": "Zfp637; Znf32", "organism": "Mouse", "refseq_name": "zinc finger protein 32 isoform 1", "refseq_ac": [ { "id": "NP_001333576", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333576", "type": "external" } ], "gene_names_uniprotkb": "Zfp637; Znf32; Zfp637", "gene_names_refseq": "Zfp637; Znf32", "protein_names_uniprotkb": "Zinc finger protein 32; Zinc finger protein 637", "protein_names_refseq": "zinc finger protein 32 isoform 1; zinc finger protein 32", "tax_id": 10090, "disease": "", "pathway": " (mmu:232337)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "20235149;21750661;25032857", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB]; Results suggest that Zfp637 inhibits muscle differentiation through a defect in the cell cycle exit by potentially regulating mTERT expression in C2C12 myoblasts, [RefSeq, PubMed]; The overexpression of Zfp637 markedly increases mTERT expression and telomerase activity, maintains telomere length, and inhibits H2O2 and D-galactose-induced senescence. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UIS3", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q80V23-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99KE8-1", "uniprot_id": [ { "id": "ZFP64_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99KE8", "type": "external" } ], "mass": 71765.0, "length": 643, "protein_name": "Zinc finger protein 64", "gene_name": "Zfp64", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Zfp64", "gene_names_refseq": "", "protein_names_uniprotkb": "Zinc finger protein 64; Zfp-64", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:22722)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "18430783;21750661;40997131;9034307", "class_list": "", "function": "May be involved in the regulation of mesenchymal cell differentiation through transactivation of NOTCH1 target genes., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P97365;Q9CWR3", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0043076 megasporocyte nucleus", "go_biological_process": "GO:0048026 positive regulation of mRNA splicing, via spliceosome;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0048762 mesenchymal cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q99KE8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AWL9-1", "uniprot_id": [ { "id": "A2AWL9_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AWL9", "type": "external" } ], "mass": 21144.0, "length": 191, "protein_name": "Reproductive homeobox 2C", "gene_name": "Rhox2c", "organism": "Mouse", "refseq_name": "reproductive homeobox 2C", "refseq_ac": [ { "id": "NP_001092788", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092788", "type": "external" } ], "gene_names_uniprotkb": "Rhox2c", "gene_names_refseq": "Rhox2.3; Rhox2b; Rhox2c", "protein_names_uniprotkb": "Reproductive homeobox 2C", "protein_names_refseq": "reproductive homeobox 2B; reproductive homeobox 2C", "tax_id": 10090, "disease": "", "pathway": " (mmu:100039948)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Transcription factor maybe involved in reproductive processes. Modulates expression of target genes encoding proteins involved in processes relevant to spermatogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2AWL9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91V17-1", "uniprot_id": [ { "id": "ZNRF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91V17", "type": "external" } ], "mass": 23843.0, "length": 227, "protein_name": "E3 ubiquitin-protein ligase ZNRF1", "gene_name": "Znrf1", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase ZNRF1 isoform a", "refseq_ac": [ { "id": "NP_001162092", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001162092", "type": "external" } ], "gene_names_uniprotkb": "Znrf1; Nin283", "gene_names_refseq": "B830022L21Rik; Rnf42; Znrf1; Zrfp1; nin283", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase ZNRF1; 2.3.2.27; Nerve injury-induced gene 283 protein; RING-type E3 ubiquitin transferase ZNRF1; Zinc/RING finger protein 1", "protein_names_refseq": "E3 ubiquitin-protein ligase ZNRF1 isoform a; E3 ubiquitin-protein ligase ZNRF1; RING-type E3 ubiquitin transferase ZNRF1; nerve injury-induced gene 283 protein; peripheral nerve injury protein nin283; ring finger protein 42; zinc ring finger protein 1; zinc/RING finger protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:170737); (R-MMU-983168)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "11427537;14561866;19737534;20107048;21183079;21750661;22057101;26572622;28593998;34428180", "class_list": "", "function": "E3 ubiquitin-protein ligase that plays a role in different processes including cell differentiation, receptor recycling or regulation of inflammation (PubMed:28593998, PubMed:37158982). Mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL (PubMed:20107048). Promotes neurodegeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons (PubMed:22057101). Ubiquitinates the Na(+)/K(+) ATPase alpha-1 subunit/ATP1A1 and thereby influences its endocytosis and/or degradation. Controls ligand-induced EGFR signaling via mediating receptor ubiquitination and recruitment of the ESCRT machinery. Acts as a negative feedback mechanism controlling TLR3 trafficking by mediating TLR3 'Lys-63'-linked polyubiquitination to reduce type I IFN production. Modulates inflammation by promoting caveolin-1/CAV1 ubiquitination and degradation to regulate TLR4-activated immune response., [UniProtKB, UniProtKB, PubMed, PubMed]; The ZNRF1-AKT-GSK3B-CRMP2 pathway plays an important role in controlling Wallerian degeneration. Publication Status: Online-Only, [RefSeq, PubMed]; This study defines ZNRF1 as a regulator of TLR4-induced inflammatory responses and reveals another mechanism for the regulation of TLR4 signalling through CAV1. Publication Status: Online-Only, [RefSeq, PubMed]; Up-regulation of ZNRF1 activity by oxidative stress leads to neuronal apoptosis and Wallerian degeneration., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C5D7", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005829 cytosol;GO:0016020 membrane;GO:0005764 lysosome", "go_biological_process": "GO:0007010 cytoskeleton organization;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0070936 protein K48-linked ubiquitination;GO:0034145 positive regulation of toll-like receptor 4 signaling pathway;GO:0034142 toll-like receptor 4 signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q91V17-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91VY9-1", "uniprot_id": [ { "id": "ZN622_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91VY9", "type": "external" } ], "mass": 53451.0, "length": 476, "protein_name": "Cytoplasmic 60S subunit biogenesis factor ZNF622", "gene_name": "Zfp622; Znf622", "organism": "Mouse", "refseq_name": "cytoplasmic 60S subunit biogenesis factor ZNF622", "refseq_ac": [ { "id": "NP_653106", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_653106", "type": "external" } ], "gene_names_uniprotkb": "Zfp622; Znf622; D15Ertd806e; Zfp622", "gene_names_refseq": "1110033B05Rik; D15Ertd806e; ZPR9; Zfp622; Znf622", "protein_names_uniprotkb": "Cytoplasmic 60S subunit biogenesis factor ZNF622; Zinc finger protein 622", "protein_names_refseq": "cytoplasmic 60S subunit biogenesis factor ZNF622", "tax_id": 10090, "disease": "azoospermia (Disease Ontology:DOID:14227)", "pathway": " (mmu:52521)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;21952136;25428506;30084848;34428180", "class_list": "", "function": "Pre-60S-associated cytoplasmic factor involved in the cytoplasmic maturation of the 60S subunit., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990275 preribosome binding;GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0030687 preribosome, large subunit precursor", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0046330 positive regulation of JNK cascade;GO:0042273 ribosomal large subunit biogenesis;GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q91VY9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JE67-1", "uniprot_id": [ { "id": "A0A0G2JE67_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A0G2JE67", "type": "external" } ], "mass": 36067.0, "length": 319, "protein_name": "Predicted gene 3409", "gene_name": "Gm3409", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC100041566 isoform X1", "refseq_ac": [ { "id": "XP_006504843", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006504843", "type": "external" } ], "gene_names_uniprotkb": "Gm3409; Gm3402", "gene_names_refseq": "100041566; Gm3409", "protein_names_uniprotkb": "Predicted gene 3409", "protein_names_refseq": "uncharacterized protein LOC100041566 isoform X1", "tax_id": 10090, "disease": "", "pathway": " (mmu:100041566)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2JE67-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q891-1", "uniprot_id": [ { "id": "E9Q891_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q891", "type": "external" } ], "mass": 35493.0, "length": 316, "protein_name": "Olfactory receptor", "gene_name": "Or8c11", "organism": "Mouse", "refseq_name": "olfactory receptor 251", "refseq_ac": [ { "id": "NP_997436", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997436", "type": "external" } ], "gene_names_uniprotkb": "Or8c11; Olfr251", "gene_names_refseq": "MOR170-15; Olfr251; Or8c11", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2MYUG-9124-8183; olfactory receptor 251", "tax_id": 10090, "disease": "", "pathway": " (mmu:404313)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9Q891-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q3G8-1", "uniprot_id": [ { "id": "NU153_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q3G8", "type": "external" } ], "mass": 152008.0, "length": 1462, "protein_name": "Nuclear pore complex protein Nup153", "gene_name": "Nup153", "organism": "Mouse", "refseq_name": "nuclear pore complex protein Nup153", "refseq_ac": [ { "id": "NP_786925", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786925", "type": "external" } ], "gene_names_uniprotkb": "Nup153", "gene_names_refseq": "B130015D15Rik; Nup153", "protein_names_uniprotkb": "Nuclear pore complex protein Nup153; 153 kDa nucleoporin; Nucleoporin Nup153", "protein_names_refseq": "153 kDa nucleoporin; nuclear pore complex protein Nup153; nucleoporin Nup153", "tax_id": 10090, "disease": "", "pathway": " (mmu:218210); (R-MMU-159227); (R-MMU-159230); (R-MMU-159231); (R-MMU-159236); (R-MMU-170822); (R-MMU-1855170); (R-MMU-1855196); (R-MMU-1855229); (R-MMU-191859); (R-MMU-3108214); (R-MMU-3232142); (R-MMU-3301854); (R-MMU-3371453); (R-MMU-4085377); (R-MMU-4551638); (R-MMU-4570464); (R-MMU-4615885)", "pathway_count": 18, "publication_count": 17, "publication_id_list": "17242355;19144319;21750661;22645316;23806337;27669760;28528544;29237092;30059200;32451376;34678516;34887587;35469018;38129135;39227892;39927985;40997131", "class_list": "", "function": "Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Nucleoporin 153 deficiency in adult neural stem cells defines a pathological protein-network signature and defective neurogenesis in a mouse model of AD. Publication Status: Online-Only, [RefSeq, PubMed]; Nucleoporin 153 links nuclear pore complex to chromatin architecture by mediating CTCF and cohesin binding. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 20, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 20, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 20, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 20, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0003690 double-stranded DNA binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0044615 nuclear pore nuclear basket;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005654 nucleoplasm;GO:0016020 membrane", "go_biological_process": "GO:0046832 negative regulation of RNA export from nucleus;GO:0006913 nucleocytoplasmic transport;GO:1990000 amyloid fibril formation;GO:0051292 nuclear pore complex assembly;GO:0051028 mRNA transport", "synthesized_glycan_count": 0, "hit_score": 3.9, "record_id": "E9Q3G8-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q7X7-1", "uniprot_id": [ { "id": "NRX2A_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q7X7", "type": "external" } ], "mass": 184885.0, "length": 1710, "protein_name": "Neurexin-2", "gene_name": "Nrxn2", "organism": "Mouse", "refseq_name": "neurexin-2 isoform 4 precursor", "refseq_ac": [ { "id": "NP_001356292", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001356292", "type": "external" } ], "gene_names_uniprotkb": "Nrxn2", "gene_names_refseq": "6430591O13Rik; Nrxn2; mKIAA0921", "protein_names_uniprotkb": "Neurexin-2; Neurexin II-alpha; Neurexin-2-alpha", "protein_names_refseq": "neurexin II alpha; neurexin II beta; neurexin-2 isoform 4 precursor; neurexin-2-alpha; neurexin-2-beta", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (mmu:18190); (R-MMU-6794361)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;21410790;21750661;22220752;24094106;24613359;28864826;30100184;30899004;32434929;33300544;35820727;38702381", "class_list": "", "function": "Conditional deletion of neurexin-2 impaired behavioral flexibility to alterations in action-outcome contingency. Publication Status: Online-Only, [RefSeq, PubMed]; Neuronal cell surface protein that may be involved in cell recognition and cell adhesion., [UniProtKB]; Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 8, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0046872 metal ion binding;GO:0005246 calcium channel regulator activity;GO:0050839 cell adhesion molecule binding;GO:0097109 neuroligin family protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0042734 presynaptic membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0097116 gephyrin clustering involved in postsynaptic density assembly;GO:0097104 postsynaptic membrane assembly;GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "E9Q7X7-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1100000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q980-1", "uniprot_id": [ { "id": "E9Q980_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q980", "type": "external" } ], "mass": 103006.0, "length": 884, "protein_name": "Zinc finger protein 788", "gene_name": "Zfp788", "organism": "Mouse", "refseq_name": "zinc finger protein 788 isoform a", "refseq_ac": [ { "id": "NP_001347603", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001347603", "type": "external" } ], "gene_names_uniprotkb": "Zfp788", "gene_names_refseq": "2810426N06Rik; Zfp788", "protein_names_uniprotkb": "Zinc finger protein 788", "protein_names_refseq": "zinc finger protein 788 isoform a", "tax_id": 10090, "disease": "", "pathway": " (mmu:67607); (R-MMU-212436)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9Q980-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BMU0-1", "uniprot_id": [ { "id": "ZNF76_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BMU0", "type": "external" } ], "mass": 61454.0, "length": 568, "protein_name": "Zinc finger protein 76", "gene_name": "Zfp523; Znf76", "organism": "Mouse", "refseq_name": "zinc finger protein 76 isoform 1", "refseq_ac": [ { "id": "NP_766205", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766205", "type": "external" } ], "gene_names_uniprotkb": "Zfp523; Znf76; Zfp523", "gene_names_refseq": "2810027J07; Zfp523; Znf76", "protein_names_uniprotkb": "Zinc finger protein 76; Zinc finger protein 523", "protein_names_refseq": "zinc finger protein 76 isoform 1; zinc finger protein 76", "tax_id": 10090, "disease": "", "pathway": " (mmu:224656)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16522640;21750661;25428506;30779550", "class_list": "", "function": "Analysis of gene regulatory interplay between TBP, PIAS1, PIAS3, PIASx, PIASy, ZFP523, and transcription factors, [RefSeq, PubMed]; Transcription factor that regulates expression of genes transcribed by both RNA polymerases II and III. Specifically recognizes and binds the Staf-binding site (SBS), a consensus DNA-binding motif present in many promoters. Able to activate expression of small nuclear RNA (snRNA) transcribed by RNA polymerases II and III. Also regulates expression of mRNAs and acts as a DNA-binding transcription repressor that inhibits the activity of the TATA-binding protein (TBP)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P9T2", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BMU0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q3A5-1", "uniprot_id": [ { "id": "E9Q3A5_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q3A5", "type": "external" } ], "mass": 98741.0, "length": 860, "protein_name": "Vomeronasal 2, receptor 105", "gene_name": "Vmn2r105", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Vmn2r105", "gene_names_refseq": "", "protein_names_uniprotkb": "Vomeronasal 2, receptor 105", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:627743)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9Q3A5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BJM5-1", "uniprot_id": [ { "id": "ZNT6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BJM5", "type": "external" } ], "mass": 51027.0, "length": 460, "protein_name": "Zinc transporter 6", "gene_name": "Slc30a6", "organism": "Mouse", "refseq_name": "zinc transporter 6 isoform 2", "refseq_ac": [ { "id": "NP_659047", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659047", "type": "external" } ], "gene_names_uniprotkb": "Slc30a6; Znt6", "gene_names_refseq": "9530029F08Rik; Slc30a6; ZnT6", "protein_names_uniprotkb": "Zinc transporter 6; Solute carrier family 30 member 6; ZnT-6", "protein_names_refseq": "solute carrier family 30 (zinc transporter), member 4; solute carrier family 30 member 6; zinc transporter 6 isoform 2; zinc transporter 6; zinc transporter-like 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:210148)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "11997387;15257151;15475177;16772872;17101726;17720550;19144319;21750661;22517741;22645316;30059200;34428180;36852467;40021952;40885482", "class_list": "", "function": "Expression of zinc transporter ZnT6 in mouse choroid epithelial cells suggests that the choroid plexus plays an important role in regulation of zinc homeostasis in the brain., [RefSeq, PubMed]; Has probably no intrinsic transporter activity but together with SLC30A5 forms a functional zinc ion:proton antiporter heterodimer, mediating zinc entry into the lumen of organelles along the secretory pathway (Probable). As part of that zinc ion:proton antiporter, contributes to zinc ion homeostasis within the early secretory pathway and regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Increased ZnT-6 immunostaining in neurons containing cytoplasmic inclusions in MCI, AD, and PD suggests a role for ZnT-6 in the pathogenesis of these lesions., [RefSeq, PubMed]; Our results revealed that ZNT7 immunoreactivity was abundantly expressed in the nerve cells of the mouse DRG.Double immunofluorescence labeling of ZNT7 and TGN38 revealed a colocalization of the two antigens in the Golgi apparatus., [RefSeq, PubMed]; Overexpression of ZnT6 causes growth inhibition, znT6 functions in zinc homeostasis and transport, [RefSeq, PubMed]; There were no differences between the mRNA expression levels of ZnT family members in undifferentiated Rcho-1 cells and differentiated Rcho-1 cells., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3UB35;Q6NVE0;Q8K4H6;Q8R4Z2;Q99JQ3", "ec_number_list": [], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0032588 trans-Golgi network membrane", "go_biological_process": "GO:0006829 zinc ion transport;GO:0006895 Golgi to endosome transport;GO:0071579 regulation of zinc ion transport;GO:1904257 zinc ion import into Golgi lumen", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q8BJM5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BI73-1", "uniprot_id": [ { "id": "ZN775_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BI73", "type": "external" } ], "mass": 60720.0, "length": 538, "protein_name": "Zinc finger protein 775", "gene_name": "Zfp775; Znf775", "organism": "Mouse", "refseq_name": "zinc finger protein 775", "refseq_ac": [ { "id": "NP_775605", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775605", "type": "external" } ], "gene_names_uniprotkb": "Zfp775; Znf775; Zfp775", "gene_names_refseq": "C130032F08Rik; Zfp775; Znf775", "protein_names_uniprotkb": "Zinc finger protein 775", "protein_names_refseq": "zinc finger protein 775", "tax_id": 10090, "disease": "", "pathway": " (mmu:243372); (R-MMU-212436)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21750661;35820727", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BI73-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CII0-1", "uniprot_id": [ { "id": "ZBT8B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CII0", "type": "external" } ], "mass": 53387.0, "length": 484, "protein_name": "Zinc finger and BTB domain-containing protein 8B", "gene_name": "Zbtb8b", "organism": "Mouse", "refseq_name": "zinc finger and BTB domain-containing protein 8B", "refseq_ac": [ { "id": "NP_705769", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_705769", "type": "external" } ], "gene_names_uniprotkb": "Zbtb8b", "gene_names_refseq": "BOZF1; Zbtb8b; Zbtb8", "protein_names_uniprotkb": "Zinc finger and BTB domain-containing protein 8B", "protein_names_refseq": "zinc finger and BTB domain containing 8; zinc finger and BTB domain-containing protein 8B", "tax_id": 10090, "disease": "", "pathway": " (mmu:215627)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3US18", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8CII0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R0E5-1", "uniprot_id": [ { "id": "ZRAS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R0E5", "type": "external" } ], "mass": 25489.0, "length": 213, "protein_name": "RNA polymerase I subunit H", "gene_name": "Polr1has", "organism": "Mouse", "refseq_name": "RNA polymerase I subunit H isoform 1", "refseq_ac": [ { "id": "NP_083878", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083878", "type": "external" } ], "gene_names_uniprotkb": "Polr1has; Tctex4; Znrd1-as; Znrd1as", "gene_names_refseq": "1700022C21Rik; Polr1has; Znrd1-as; Znrd1as", "protein_names_uniprotkb": "RNA polymerase I subunit H; Putative uncharacterized protein ZNRD1-AS1; T-complex testis-expressed protein 4; ZNRD1 antisense RNA 1; ZNRD1 antisense gene protein 1", "protein_names_refseq": "RNA polymerase I subunit H isoform 1; T-complex testis-expressed protein 4; ZNRD1 antisense RNA 1; ZNRD1 antisense gene protein 1; zinc ribbon domain containing 1, antisense", "tax_id": 10090, "disease": "", "pathway": " (mmu:76416)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "1718647;21750661;35820727", "class_list": "", "function": "May be involved in male sterility., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9DA28", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8R0E5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99LP8-1", "uniprot_id": [ { "id": "YIPF2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99LP8", "type": "external" } ], "mass": 34900.0, "length": 312, "protein_name": "Protein YIPF2", "gene_name": "Yipf2", "organism": "Mouse", "refseq_name": "protein YIPF2", "refseq_ac": [ { "id": "NP_001192086", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192086", "type": "external" } ], "gene_names_uniprotkb": "Yipf2", "gene_names_refseq": "1300010K09Rik; Yipf2", "protein_names_uniprotkb": "Protein YIPF2; YIP1 family member 2", "protein_names_refseq": "protein YIPF2", "tax_id": 10090, "disease": "", "pathway": " (mmu:74766)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;37828378", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q99LF3", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0031902 late endosome membrane;GO:0030133 transport vesicle;GO:0005797 Golgi medial cisterna;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q99LP8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CR11-1", "uniprot_id": [ { "id": "YETS4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CR11", "type": "external" } ], "mass": 26530.0, "length": 227, "protein_name": "YEATS domain-containing protein 4", "gene_name": "Yeats4", "organism": "Mouse", "refseq_name": "YEATS domain-containing protein 4", "refseq_ac": [ { "id": "NP_080846", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080846", "type": "external" } ], "gene_names_uniprotkb": "Yeats4; Gas41", "gene_names_refseq": "4930573H17Rik; B230215M10Rik; GAS41; NuBI-1; Yeats4", "protein_names_uniprotkb": "YEATS domain-containing protein 4; Gas41; Glioma-amplified sequence 41 homolog", "protein_names_refseq": "YEATS domain-containing protein 4; glioma-amplified sequence 41 homolog; glioma-amplified sequence-41", "tax_id": 10090, "disease": "high grade glioma (Disease Ontology:DOID:3070)", "pathway": " (mmu:64050); (R-MMU-8866907)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "21750661;29187734;29900004;30084848;31434684;34428180", "class_list": "", "function": "Chromatin reader component of the NuA4 histone acetyltransferase (HAT) complex, a complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (By similarity). Specifically recognizes and binds acylated histone H3, with a preference for histone H3 diacetylated at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac) or histone H3 diacetylated at 'Lys-14' and 'Lys-27' (H3K14ac and H3K27ac) (By similarity). Also able to recognize and bind crotonylated histone H3 (By similarity). May also recognize and bind histone H3 succinylated at 'Lys-122' (H3K122succ); additional evidences are however required to confirm this result in vivo (By similarity). Plays a key role in histone variant H2AZ1/H2A.Z deposition into specific chromatin regions: recognizes and binds H3K14ac and H3K27ac on the promoters of actively transcribed genes and recruits NuA4-related complex to deposit H2AZ1/H2A.Z (By similarity). H2AZ1/H2A.Z deposition is required for maintenance of embryonic stem cell (PubMed:29900004)., [UniProtKB, UniProtKB, PubMed]; Findings indicate that the YEATS domain-containing protein 4 (Yeats4)-LIM domain transcription factor LMO4 (Lmo4) axis is required for Innate lymphoid cells (ILCs) lineage commitment., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CW86", "ec_number_list": [], "go_molecular_function": "GO:0042393 histone binding;GO:0140044 histone H3K18ac reader activity;GO:0140119 histone H3K27ac reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0031965 nuclear membrane;GO:0035267 NuA4 histone acetyltransferase complex;GO:0000786 nucleosome", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9CR11-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQU5-1", "uniprot_id": [ { "id": "ZWINT_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQU5", "type": "external" } ], "mass": 28713.0, "length": 252, "protein_name": "Outer kinetochore KNL1 complex subunit ZWINT", "gene_name": "Zwint", "organism": "Mouse", "refseq_name": "outer kinetochore KNL1 complex subunit ZWINT", "refseq_ac": [ { "id": "NP_001280612", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001280612", "type": "external" } ], "gene_names_uniprotkb": "Zwint; D10Ertd749e", "gene_names_refseq": "2010007E07Rik; 2600001N01Rik; D10Ertd749e; Zwint-1; Zwint", "protein_names_uniprotkb": "Outer kinetochore KNL1 complex subunit ZWINT; ZW10 interactor; ZW10-interacting protein 1; Zwint-1", "protein_names_refseq": "ZW10-interacting protein 1; outer kinetochore KNL1 complex subunit ZWINT", "tax_id": 10090, "disease": "", "pathway": " (mmu:52696); (R-MMU-141430); (R-MMU-141444); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-5663220); (R-MMU-68877); (R-MMU-9648025)", "pathway_count": 8, "publication_count": 10, "publication_id_list": "21183079;21750661;25428506;25605945;26486467;30084848;30779550;34203471;34428180;36852467", "class_list": "", "function": "Acts as a component of the outer kinetochore KNL1 complex that serves as a docking point for spindle assembly checkpoint components and mediates microtubule-kinetochore interactions. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules. The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle (By similarity). Targets the RZZ complex to the kinetochore at prometaphase (By similarity). Recruits MAD2L1 to the kinetochore, but is not required for BUB1B localization (PubMed:26486467). In addition to orienting mitotic chromosomes, it is also essential for alignment of homologous chromosomes during meiotic metaphase I (PubMed:26486467). In meiosis I, required to activate the spindle assembly checkpoint at unattached kinetochores to correct erroneous kinetochore-microtubule attachments (PubMed:26486467)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UYT8;Q91VI4;Q9D0W9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030425 dendrite;GO:0016604 nuclear body", "go_biological_process": "GO:0031619 homologous chromosome orientation in meiotic metaphase I;GO:0051301 cell division;GO:0007094 mitotic spindle assembly checkpoint signaling;GO:0051649 establishment of localization in cell;GO:0000070 mitotic sister chromatid segregation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9CQU5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D0L1-1", "uniprot_id": [ { "id": "ZBED3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D0L1", "type": "external" } ], "mass": 25609.0, "length": 228, "protein_name": "Zinc finger BED domain-containing protein 3", "gene_name": "Zbed3", "organism": "Mouse", "refseq_name": "zinc finger BED domain-containing protein 3", "refseq_ac": [ { "id": "NP_001289467", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289467", "type": "external" } ], "gene_names_uniprotkb": "Zbed3", "gene_names_refseq": "0610037K01Rik; 2610005H11Rik; Zbed3", "protein_names_uniprotkb": "Zinc finger BED domain-containing protein 3; Axin-interacting protein", "protein_names_refseq": "axin-interacting protein; zinc finger BED domain-containing protein 3; zinc finger, BED domain containing 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:72114)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "19141611;21750661;24283382;25428506;28992324;31219806;33822906;34427978", "class_list": "", "function": "Acts as a positive regulator in the activation of the canonical Wnt/beta-catenin signaling pathway by stabilizing cytoplasmic beta-catenin (PubMed:19141611). Involved in transcription activation of Wnt target gene expression (PubMed:19141611). Plays a role in symmetric division of blastomeres in the early stages of embryogenesis via regulation of mitotic spindle central positioning and organization of the F-actin filament network (PubMed:28992324). Plays a role in regulating the distribution of cellular organelles, via modulation of cytoskeletal dynamics and cytoplasmic lattice formation (PubMed:28992324)., [UniProtKB, PubMed, PubMed]; Long noncoding RNA ZBED3-AS1 restrains breast cancer progression by targeting the microRNA-513a-5p/KLF6 axis., [RefSeq, PubMed]; This gene encodes a member of the zinc finger protein superfamily. This protein may regulate the Wnt/beta-catenin signaling pathway. This protein may be involved in insulin resistance and type 2 diabetes in humans. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]., [RefSeq]; Zbed3 Is Indispensable for Wnt Signaling Regulation of Cortical Layers Formation in Developing Brain., [RefSeq, PubMed]; Zbed3 is a novel Axin-binding protein that is involved in Wnt/beta-catenin signaling modulation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0051293 establishment of spindle localization;GO:0007015 actin filament organization;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0001933 negative regulation of protein phosphorylation;GO:0050821 protein stabilization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9D0L1-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CWV7-1", "uniprot_id": [ { "id": "ZSWM1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CWV7", "type": "external" } ], "mass": 51481.0, "length": 455, "protein_name": "Zinc finger SWIM domain-containing protein 1", "gene_name": "Zswim1", "organism": "Mouse", "refseq_name": "zinc finger SWIM domain-containing protein 1", "refseq_ac": [ { "id": "NP_082304", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082304", "type": "external" } ], "gene_names_uniprotkb": "Zswim1", "gene_names_refseq": "2410003H12Rik; Zswim1", "protein_names_uniprotkb": "Zinc finger SWIM domain-containing protein 1", "protein_names_refseq": "zinc finger SWIM domain-containing protein 1; zinc finger, SWIM domain containing 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:71971)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;25428506;31219806;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A5J3;Q8R163", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9CWV7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91VU1-1", "uniprot_id": [ { "id": "YIPF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91VU1", "type": "external" } ], "mass": 34258.0, "length": 306, "protein_name": "Protein YIPF1", "gene_name": "Yipf1", "organism": "Mouse", "refseq_name": "protein YIPF1 isoform 1", "refseq_ac": [ { "id": "NP_663525", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663525", "type": "external" } ], "gene_names_uniprotkb": "Yipf1", "gene_names_refseq": "C030002N13Rik; Yipf1", "protein_names_uniprotkb": "Protein YIPF1; YIP1 family member 1", "protein_names_refseq": "protein YIPF1 isoform 1; protein YIPF1", "tax_id": 10090, "disease": "", "pathway": " (mmu:230584)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TZU1", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0031902 late endosome membrane;GO:0030133 transport vesicle", "go_biological_process": "GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q91VU1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BR70-1", "uniprot_id": [ { "id": "YIPF6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BR70", "type": "external" } ], "mass": 26088.0, "length": 236, "protein_name": "Protein YIPF6", "gene_name": "Yipf6", "organism": "Mouse", "refseq_name": "protein YIPF6", "refseq_ac": [ { "id": "NP_997516", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997516", "type": "external" } ], "gene_names_uniprotkb": "Yipf6", "gene_names_refseq": "A430107J06Rik; Yipf6", "protein_names_uniprotkb": "Protein YIPF6; YIP1 family member 6", "protein_names_refseq": "YIP1 family member 6; protein YIPF6", "tax_id": 10090, "disease": "", "pathway": " (mmu:77929); (R-MMU-432722)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;22802641;31289229", "class_list": "", "function": "A tissue- and organ-specific function for Yipf6 in the maintenance of intestinal homeostasis and implicate the orthologous human gene as a disease susceptibility locus., [RefSeq, PubMed]; May be required for stable YIPF1 and YIPF2 protein expression., [UniProtKB, UniProtKB]; YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C531", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0005797 Golgi medial cisterna;GO:0005801 cis-Golgi network", "go_biological_process": "GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0060576 intestinal epithelial cell development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BR70-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BZ89-1", "uniprot_id": [ { "id": "ZN322_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BZ89", "type": "external" } ], "mass": 48492.0, "length": 410, "protein_name": "Zinc finger protein 322", "gene_name": "Zfp322a; Znf322", "organism": "Mouse", "refseq_name": "zinc finger protein 322", "refseq_ac": [ { "id": "NP_001104577", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104577", "type": "external" } ], "gene_names_uniprotkb": "Zfp322a; Znf322; Zfp322a; Znf322a", "gene_names_refseq": "Zfp322a; Znf322a; Znf322", "protein_names_uniprotkb": "Zinc finger protein 322; Zinc finger protein 322A", "protein_names_refseq": "zinc finger protein 322", "tax_id": 10090, "disease": "", "pathway": " (mmu:218100)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16325481;21750661;24550733;34428180", "class_list": "", "function": "Our results demonstrate that Zfp322a is a novel essential component of the transcription factor network which maintains the identity of mouse ES cells. Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptional activator. Important for maintenance of pluripotency in embryonic stem cells. Binds directly to the POU5F1 distal enhancer and the NANOG proximal promoter, and enhances expression of both genes. Can also bind to numerous other gene promoters and regulates expression of many other pluripotency factors, either directly or indirectly. Promotes inhibition of MAPK signaling during embryonic stem cell differentiation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K0A0;Q91W42", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987 cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:1902459 positive regulation of stem cell population maintenance;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BZ89-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91VN1-1", "uniprot_id": [ { "id": "ZNF24_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91VN1", "type": "external" } ], "mass": 41919.0, "length": 368, "protein_name": "Zinc finger protein 24", "gene_name": "Zfp24; Znf24", "organism": "Mouse", "refseq_name": "zinc finger protein 24", "refseq_ac": [ { "id": "NP_067534", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067534", "type": "external" } ], "gene_names_uniprotkb": "Zfp24; Znf24; Hmcns; Zfp191; Zfp24", "gene_names_refseq": "3526401F17Rik; 5033419P20Rik; KOX17; ZF-12; Zfp191; Zfp24; Znf24", "protein_names_uniprotkb": "Zinc finger protein 24; Hypomyelinated CNS protein; Zinc finger protein 191; Zinc finger protein ZF-12", "protein_names_refseq": "hypomyelinated CNS protein; zfp-191; zinc finger protein 191; zinc finger protein 24; zinc finger protein ZF-12", "tax_id": 10090, "disease": "", "pathway": " (mmu:59057)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10542327;12812053;17064688;18096443;18685786;19544452;20080941;21750661;29791837;30084848;30779550;36210013", "class_list": "", "function": "Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence. Has transcription repressor activity in vitro., [UniProtKB, PubMed, PubMed]; ZFP24 binds to a consensus DNA sequence in proximity to genes important for oligodendrocyte differentiation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5MDG8;Q9WUQ0", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0042552 myelination;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q91VN1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0I7-1", "uniprot_id": [ { "id": "YLPM1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R0I7", "type": "external" } ], "mass": 155129.0, "length": 1386, "protein_name": "YLP motif-containing protein 1", "gene_name": "Ylpm1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ylpm1; Zap3; Zap", "gene_names_refseq": "", "protein_names_uniprotkb": "YLP motif-containing protein 1; Nuclear protein ZAP3", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:56531)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;10716735;15511642;21606357;21750661;22517741;22645316;24129315;25428506;34678516;36852467;40885482;40997131", "class_list": "", "function": "Plays a role in the reduction of telomerase activity during differentiation of embryonic stem cells by binding to the core promoter of TERT and controlling its down-regulation., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "E9QKY3;Q7TMM4", "ec_number_list": [], "go_molecular_function": "GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck", "go_biological_process": "GO:0032204 regulation of telomere maintenance;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q9R0I7-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CX48-1", "uniprot_id": [ { "id": "ZCH10_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CX48", "type": "external" } ], "mass": 19148.0, "length": 178, "protein_name": "Zinc finger CCHC domain-containing protein 10", "gene_name": "Zcchc10", "organism": "Mouse", "refseq_name": "zinc finger CCHC domain-containing protein 10", "refseq_ac": [ { "id": "NP_080755", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080755", "type": "external" } ], "gene_names_uniprotkb": "Zcchc10", "gene_names_refseq": "2410141K03Rik; D11Ertd416e; Zcchc10", "protein_names_uniprotkb": "Zinc finger CCHC domain-containing protein 10", "protein_names_refseq": "zinc finger CCHC domain-containing protein 10", "tax_id": 10090, "disease": "", "pathway": " (mmu:67966)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CX48-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1D8-1", "uniprot_id": [ { "id": "ZKSC5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z1D8", "type": "external" } ], "mass": 93788.0, "length": 819, "protein_name": "Zinc finger protein with KRAB and SCAN domains 5", "gene_name": "Zkscan5", "organism": "Mouse", "refseq_name": "zinc finger protein with KRAB and SCAN domains 5 isoform 1", "refseq_ac": [ { "id": "NP_057892", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_057892", "type": "external" } ], "gene_names_uniprotkb": "Zkscan5; Zfp95", "gene_names_refseq": "Zfp95; Zkscan5; hKraba1", "protein_names_uniprotkb": "Zinc finger protein with KRAB and SCAN domains 5; Zfp-95; Zinc finger protein 95", "protein_names_refseq": "zfp-95; zinc finger protein 95; zinc finger protein with KRAB and SCAN domains 5 isoform 1; zinc finger protein with KRAB and SCAN domains 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:22757); (R-MMU-212436)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "12860387;21750661;34428180", "class_list": "", "function": "Cloning and characterization of its expression during spermatogenesis, [RefSeq, PubMed]; May be involved in transcriptional regulation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QLY2", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9Z1D8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CR50-1", "uniprot_id": [ { "id": "ZN363_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CR50", "type": "external" } ], "mass": 30014.0, "length": 261, "protein_name": "RING finger and CHY zinc finger domain-containing protein 1", "gene_name": "Rchy1", "organism": "Mouse", "refseq_name": "RING finger and CHY zinc finger domain-containing protein 1 isoform 2", "refseq_ac": [ { "id": "NP_001258726", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258726", "type": "external" } ], "gene_names_uniprotkb": "Rchy1; Arnip; Chimp; Zfp363; Znf363", "gene_names_refseq": "ARNIP; CHIMP; Pirh2; Rchy1; Zfp363; Znf363", "protein_names_uniprotkb": "RING finger and CHY zinc finger domain-containing protein 1; 2.3.2.27; Androgen receptor N-terminal-interacting protein; CH-rich-interacting match with PLAG1; E3 ubiquitin-protein ligase Pirh2; RING-type E3 ubiquitin transferase RCHY1; Zinc finger protein 363", "protein_names_refseq": "CH-rich-interacting match with PLAG1; E3 ubiquitin-protein ligase Pirh2; RING finger and CHY zinc finger domain-containing protein 1 isoform 2; RING finger and CHY zinc finger domain-containing protein 1; RING-type E3 ubiquitin transferase RCHY1; androgen receptor N-terminal-interacting protein; zinc finger protein 363", "tax_id": 10090, "disease": "sciatic neuropathy (Disease Ontology:DOID:11446)", "pathway": " (mmu:68098); (R-MMU-110320); (R-MMU-983168); (R-MMU-9954709)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "12200228;12654245;15547185;21750661;31630802;34428180;37579947;37882235;38740775", "class_list": "", "function": "Cloning and characterization of an androgen receptor N-terminal-interacting protein with ubiquitin-protein ligase activity [androgen-receptor N-terminal-interacting protein; mARNIP], [RefSeq, PubMed]; E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins, including p53/TP53, TP73, HDAC1 and CDKN1B (By similarity). Mediates ubiquitination and degradation of p53/TP53; preferentially acts on tetrameric p53/TP53 (By similarity). Catalyzes monoubiquitinates the translesion DNA polymerase POLH (PubMed:12654245). Involved in the ribosome-associated quality control (RQC) pathway, which mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes: RCHY1 acts downstream of NEMF and recognizes CAT tails associated with stalled nascent chains, leading to their ubiquitination and degradation (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; Pirh2 modulates amyloid-beta aggregation through the regulation of glucose-regulated protein 78 and chaperone-mediated signaling., [RefSeq, PubMed]; Pirh2 modulates the mitochondrial function and cytochrome c-mediated neuronal death during Alzheimer's disease. Publication Status: Online-Only, [RefSeq, PubMed]; Pirh2-dependent DNA damage in neurons induced by the G-quadruplex ligand pyridostatin., [RefSeq, PubMed]; These data provide an evidence that RCHY1 negatively regulates HDAC2., [RefSeq, PubMed]; These results are consistent with the hypothesis that increased Pirh2 expression affects lung tumorigenesis by reducing p53 activity., [RefSeq, PubMed]; This gene encodes a protein containing CHY-, CTCHY-, and RING-type zinc-fingers. The encoded protein functions as an E3 ubiquitin ligase, and mediates the degradation of target proteins such as p53. The activity of this protein is important in cell cycle regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]., [RefSeq]; This protein is a p53-induced ubiquitin-protein ligase which promotes p53 degradation. GeneRIF: Pirh2 (Zfp363), a gene regulated by p53, encodes a RING-H2 domain-containing protein with intrinsic ubiquitin-protein ligase activity. Pirh2 physically interacts with p53 and promotes ubiquitination and degradation of p53 independently of Mdm2., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q920H0", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" } ], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0061630 ubiquitin protein ligase activity;GO:0002039 p53 binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0016567 protein ubiquitination;GO:0031398 positive regulation of protein ubiquitination;GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9CR50-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80TS5-1", "uniprot_id": [ { "id": "ZN423_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80TS5", "type": "external" } ], "mass": 145351.0, "length": 1292, "protein_name": "Zinc finger protein 423", "gene_name": "Zfp423; Znf423", "organism": "Mouse", "refseq_name": "zinc finger protein 423 isoform 1", "refseq_ac": [ { "id": "NP_201584", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_201584", "type": "external" } ], "gene_names_uniprotkb": "Zfp423; Znf423; Ebfaz; Kiaa0760; Nur12; Oaz; Zfp423", "gene_names_refseq": "Ebfaz; Roaz; Zfp104; Zfp423; Znf423; ataxia1; mKIAA0760; nur12", "protein_names_uniprotkb": "Zinc finger protein 423; Early B-cell factor-associated zinc finger protein; Olf1/EBF-associated zinc finger protein; Smad- and Olf-interacting zinc finger protein", "protein_names_refseq": "early B-cell factor associated zinc finger protein; early B-cell factor associated zinc finger transcription factor; olf1/EBF-associated zinc finger protein; smad- and Olf-interacting zinc finger protein; zinc finger protein 104; zinc finger protein 423 isoform 1", "tax_id": 10090, "disease": "nephronophthisis 14 (Disease Ontology:DOID:0111122); Dandy-Walker syndrome (Disease Ontology:DOID:2785); cerebellar disease (Disease Ontology:DOID:2786)", "pathway": " (mmu:94187)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14623329;15048087;16943432;17151198;17521568;17524391;21750661;34428180", "class_list": "", "function": "Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons. Controls proliferation and differentiation of neural precursors in cerebellar vermis formation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B2RSW4;Q6PCP2;Q6X497;Q8CIQ1;Q9ESD2", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007219 Notch signaling pathway;GO:0007399 nervous system development;GO:0050872 white fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q80TS5-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BFR1-1", "uniprot_id": [ { "id": "ZCCHL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BFR1", "type": "external" } ], "mass": 32831.0, "length": 296, "protein_name": "Zinc finger CCCH-type antiviral protein 1-like", "gene_name": "Zc3hav1l", "organism": "Mouse", "refseq_name": "zinc finger CCCH-type antiviral protein 1-like", "refseq_ac": [ { "id": "NP_766055", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766055", "type": "external" } ], "gene_names_uniprotkb": "Zc3hav1l", "gene_names_refseq": "B130055L09Rik; E430016P22Rik; Zc3hav1l", "protein_names_uniprotkb": "Zinc finger CCCH-type antiviral protein 1-like", "protein_names_refseq": "zinc finger CCCH-type antiviral protein 1-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:209032)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "25428506;30084848;30779550", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C3Z2", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BFR1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGZ8-1", "uniprot_id": [ { "id": "ZPLD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGZ8", "type": "external" } ], "mass": 45448.0, "length": 415, "protein_name": "Zona pellucida-like domain-containing protein 1", "gene_name": "Zpld1", "organism": "Mouse", "refseq_name": "zona pellucida-like domain-containing protein 1 precursor", "refseq_ac": [ { "id": "NP_848835", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848835", "type": "external" } ], "gene_names_uniprotkb": "Zpld1", "gene_names_refseq": "9430016A21Rik; Zpld1", "protein_names_uniprotkb": "Zona pellucida-like domain-containing protein 1; Cupulin; ZP domain-containing protein 1", "protein_names_refseq": "ZP domain-containing protein 1; cupulin; zona pellucida-like domain-containing protein 1 precursor; zona pellucida-like domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:239852)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "31455802", "class_list": "", "function": "Glycoprotein which is a component of the gelatinous extracellular matrix in the cupulae of the vestibular organ., [UniProtKB, UniProtKB]; Spontaneous mutations of the Zpld1 gene in mice cause semicircular canal dysfunction but do not impair gravity receptor or hearing functions. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q14BA1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0060005 vestibular reflex", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BGZ8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BH05-1", "uniprot_id": [ { "id": "ZN750_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BH05", "type": "external" } ], "mass": 76645.0, "length": 703, "protein_name": "Zinc finger protein 750", "gene_name": "Znf750", "organism": "Mouse", "refseq_name": "zinc finger protein 750", "refseq_ac": [ { "id": "NP_848878", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848878", "type": "external" } ], "gene_names_uniprotkb": "Znf750; Zfp750", "gene_names_refseq": "A030007D23Rik; Zfp750; Znf750", "protein_names_uniprotkb": "Zinc finger protein 750", "protein_names_refseq": "protein ZNF750; zinc finger protein 750", "tax_id": 10090, "disease": "", "pathway": " (mmu:319530); (R-MMU-212436)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "27488654;34428180;37115925;37660780;40021952", "class_list": "", "function": "Transcription factor involved in epidermis differentiation. Required for terminal epidermal differentiation: acts downstream of p63/TP63 and activates expression of late epidermal differentiation genes. Specifically binds to the promoter of KLF4 and promotes its expression (By similarity)., [UniProtKB]; ZFP750 affects the cutaneous barrier through regulating lipid metabolism., [RefSeq, PubMed]; ZNF750 Regulates Skin Barrier Function by Driving Cornified Envelope and Lipid Processing Pathways., [RefSeq, PubMed]; ZNF750/MPZL3 pathway plays a critical role in the pathogenesis of seborrheic dermatitis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B1ATU1;B9EKG8;Q66JP3;Q8C0L1", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990841 promoter-specific chromatin binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0008544 epidermis development;GO:0010719 negative regulation of epithelial to mesenchymal transition", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BH05-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BI69-1", "uniprot_id": [ { "id": "ZN784_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BI69", "type": "external" } ], "mass": 32230.0, "length": 297, "protein_name": "Zinc finger protein 784", "gene_name": "Znf784", "organism": "Mouse", "refseq_name": "zinc finger protein 784", "refseq_ac": [ { "id": "NP_001034621", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034621", "type": "external" } ], "gene_names_uniprotkb": "Znf784; Zfp784", "gene_names_refseq": "C730049F21Rik; Zfp784; Znf784", "protein_names_uniprotkb": "Zinc finger protein 784", "protein_names_refseq": "zinc finger protein 784", "tax_id": 10090, "disease": "", "pathway": " (mmu:654801); (R-MMU-212436)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8BI69-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BKW4-1", "uniprot_id": [ { "id": "ZCHC4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BKW4", "type": "external" } ], "mass": 58567.0, "length": 512, "protein_name": "rRNA N(6)-adenosine-methyltransferase ZCCHC4", "gene_name": "Zcchc4", "organism": "Mouse", "refseq_name": "rRNA N(6)-adenosine-methyltransferase ZCCHC4 isoform 2", "refseq_ac": [ { "id": "NP_001295073", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001295073", "type": "external" } ], "gene_names_uniprotkb": "Zcchc4", "gene_names_refseq": "4930449I23Rik; Zcchc4", "protein_names_uniprotkb": "rRNA N(6)-adenosine-methyltransferase ZCCHC4; 2.1.1.-; Zinc finger CCHC domain-containing protein 4", "protein_names_refseq": "rRNA N(6)-adenosine-methyltransferase ZCCHC4 isoform 2; rRNA N(6)-adenosine-methyltransferase ZCCHC4; rRNA N6-adenosine-methyltransferase ZCCHC4; zinc finger CCHC domain-containing protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:78796)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;31219806;31599954", "class_list": "", "function": "rRNA N6-methyltransferase that specifically methylates the adenine in position 4220 of 28S rRNA. N6-methylation of adenine(4220) in 28S rRNA is required for translation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UTX6;Q9D2I1", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding;GO:1904047 S-adenosyl-L-methionine binding;GO:0008988 rRNA (adenine-N6-)-methyltransferase activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0031167 rRNA methylation;GO:0045727 positive regulation of translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BKW4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BQQ1-1", "uniprot_id": [ { "id": "ZDH14_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BQQ1", "type": "external" } ], "mass": 53659.0, "length": 489, "protein_name": "Palmitoyltransferase ZDHHC14", "gene_name": "Zdhhc14", "organism": "Mouse", "refseq_name": "palmitoyltransferase ZDHHC14", "refseq_ac": [ { "id": "NP_666185", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666185", "type": "external" } ], "gene_names_uniprotkb": "Zdhhc14", "gene_names_refseq": "B530001K09Rik; New1cp; Zdhhc14", "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC14; 2.3.1.225; DHHC domain-containing cysteine-rich protein 14; DHHC-14; NEW1 domain-containing protein; NEW1CP; Zinc finger DHHC domain-containing protein 14", "protein_names_refseq": "DHHC domain-containing cysteine-rich protein 14; DHHC-14; NEW1 domain containing protein; palmitoyltransferase ZDHHC14; probable palmitoyltransferase ZDHHC14; zinc finger DHHC domain-containing protein 14", "tax_id": 10090, "disease": "", "pathway": " (mmu:224454)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21183079;30084848;33185190;34428180", "class_list": "", "function": "Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates. May have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and thereby regulate G protein-coupled receptor signaling. May play a role in cell differentiation and apoptosis., [UniProtKB, UniProtKB]; The palmitoyl acyltransferase ZDHHC14 controls Kv1-family potassium channel clustering at the axon initial segment. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BNR2;Q8CFN0", "ec_number_list": [ { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" }, { "id": "6.3.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.1.2", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0019706 protein-cysteine S-palmitoyltransferase activity;GO:0016409 palmitoyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006612 protein targeting to membrane;GO:0018230 peptidyl-L-cysteine S-palmitoylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BQQ1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BT35-1", "uniprot_id": [ { "id": "MTLN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BT35", "type": "external" } ], "mass": 6529.0, "length": 56, "protein_name": "Mitoregulin", "gene_name": "Mtln", "organism": "Mouse", "refseq_name": "mitoregulin", "refseq_ac": [ { "id": "NP_001371064", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001371064", "type": "external" } ], "gene_names_uniprotkb": "Mtln; Lemp; Moxi; Mpm; Smim37", "gene_names_refseq": "1500011K16Rik; Moxi; Mpm; Mtln", "protein_names_uniprotkb": "Mitoregulin; Micropeptide in mitochondria; Micropeptide regulator of beta-oxidation; Small integral membrane protein 37; lncRNA-encoded micropeptide", "protein_names_refseq": "lncRNA-encoded micropeptide; micropeptide in mitochondria; micropeptide regulator of beta-oxidation; mitoregulin; small integral membrane protein 37", "tax_id": 10090, "disease": "", "pathway": " (mmu:67885)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "29949755;29949756;30796188;31296841;32243843;32393776", "class_list": "", "function": "MOXI overexpression leads to enhanced beta-oxidation. Hearts from MOXI knockout mice preferentially oxidize carbohydrates over fatty acids in an isolated perfused heart system compared to wild-type., [RefSeq, PubMed]; Mtln overexpression increases mitochondrial membrane potential, respiration rates, and Ca(2+) retention capacity while decreasing mitochondrial ROS and matrix-free Ca(2+). Mtln-knockout mice display perturbations in mitochondrial respiratory (super)complex formation and activity, fatty acid oxidation, tricarboxylic acid (TCA) cycle enzymes, and Ca(2+) retention capacity., [RefSeq, PubMed]; Positively regulates mitochondrial complex assembly and/or stability (PubMed:29949756). Increases mitochondrial membrane potential while decreasing mitochondrial reactive oxygen species (By similarity). Increases mitochondrial respiration rate (PubMed:31296841). Increased mitochondrial respiratory activity promotes myogenic differentiation which facilitates muscle growth and regeneration (PubMed:31296841, PubMed:32393776). Increases mitochondrial calcium retention capacity (PubMed:29949756). Plays a role in maintenance of cellular lipid composition through its interaction with cytochrome b5 reductase CYB5R3 which is required for mitochondrial respiratory complex I activity (PubMed:30796188). Interacts with the mitochondrial trifunctional enzyme complex (MTE) and enhances fatty acid beta-oxidation (PubMed:29949755, PubMed:32243843). Not required for MTE formation or stability (PubMed:29949755). Modulates triglyceride clearance in adipocytes through its role in regulating fatty acid beta-oxidation and lipolysis (PubMed:32243843)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0051284 positive regulation of sequestering of calcium ion;GO:0006629 lipid metabolic process;GO:0006635 fatty acid beta-oxidation;GO:0032000 positive regulation of fatty acid beta-oxidation;GO:0031334 positive regulation of protein-containing complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BT35-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BV42-1", "uniprot_id": [ { "id": "ZN786_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BV42", "type": "external" } ], "mass": 89484.0, "length": 777, "protein_name": "Zinc finger protein 786", "gene_name": "Znf786", "organism": "Mouse", "refseq_name": "zinc finger protein 786", "refseq_ac": [ { "id": "NP_808550", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808550", "type": "external" } ], "gene_names_uniprotkb": "Znf786; Zfp786", "gene_names_refseq": "A730012O14Rik; Zfp786; Znf786", "protein_names_uniprotkb": "Zinc finger protein 786", "protein_names_refseq": "zinc finger protein 786", "tax_id": 10090, "disease": "", "pathway": " (mmu:330301); (R-MMU-212436)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8BV42-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BXJ8-1", "uniprot_id": [ { "id": "Z385B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BXJ8", "type": "external" } ], "mass": 51356.0, "length": 482, "protein_name": "Zinc finger protein 385B", "gene_name": "Zfp385b; Znf385b", "organism": "Mouse", "refseq_name": "zinc finger protein 385B isoform 2", "refseq_ac": [ { "id": "NP_001106870", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106870", "type": "external" } ], "gene_names_uniprotkb": "Zfp385b; Znf385b; Zfp385b; Zfp533; Znf533", "gene_names_refseq": "B830010L13Rik; C130013B13Rik; Zfp385b; Zfp533; Znf385b", "protein_names_uniprotkb": "Zinc finger protein 385B; Zinc finger protein 533", "protein_names_refseq": "zinc finger protein 385B isoform 2; zinc finger protein 533", "tax_id": 10090, "disease": "", "pathway": " (mmu:241494)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;26755636;40885482;40997131", "class_list": "", "function": "May play a role in p53/TP53-mediated apoptosis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BWQ7", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0001650 fibrillar center", "go_biological_process": "GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BXJ8-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BYK6-1", "uniprot_id": [ { "id": "YTHD3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BYK6", "type": "external" } ], "mass": 63961.0, "length": 585, "protein_name": "YTH domain-containing family protein 3", "gene_name": "Ythdf3", "organism": "Mouse", "refseq_name": "YTH domain-containing family protein 3 isoform 2", "refseq_ac": [ { "id": "NP_001139391", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139391", "type": "external" } ], "gene_names_uniprotkb": "Ythdf3", "gene_names_refseq": "9130022A11Rik; Ythdf3", "protein_names_uniprotkb": "YTH domain-containing family protein 3", "protein_names_refseq": "YTH domain family 3; YTH domain-containing family protein 3 isoform 2; YTH domain-containing family protein 3", "tax_id": 10090, "disease": "disease of metabolism (Disease Ontology:DOID:0014667)", "pathway": " (mmu:229096)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "10.1101/2023.09.13.557529;20173027;21158410;22517741;22645316;25428506;29237092;30059200;30084848;30591559;31616917;32782141;32848054;32905781;32943573;34428180;35822049;36852467;38195035;39081030;40021952;40885482;40997131", "class_list": "", "function": "Deletion of YTHDF1 (not YTHDF3) reduced brain and gut damage after traumatic brain injury., [RefSeq, PubMed]; Findings uncover the role of YTHDF3 as a negative regulator of antiviral immunity through the translational promotion of FOXO3 mRNA under homeostatic conditions, adding insight into the networks of RNA-binding protein-RNA interactions in homeostatically maintaining host antiviral immune function and preventing inflammatory response., [RefSeq, PubMed]; METTL3-mediated m[6]A modification of SOX4 regulates osteoblast proliferation and differentiation via YTHDF3 recognition., [RefSeq, PubMed]; Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates their stability (PubMed:32905781, PubMed:32943573). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing (PubMed:32943573). Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex or PAN3 (PubMed:32905781, PubMed:32943573). The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) share m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation (PubMed:32943573). Acts as a negative regulator of type I interferon response by down-regulating interferon-stimulated genes (ISGs) expression: acts by binding to FOXO3 mRNAs (PubMed:30591559). Binds to FOXO3 mRNAs independently of METTL3-mediated m6A modification (PubMed:30591559). Can also act as a regulator of mRNA stability in cooperation with YTHDF2 by binding to m6A-containing mRNA and promoting their degradation (By similarity). Recognizes and binds m6A-containing circular RNAs (circRNAs); circRNAs are generated through back-splicing of pre-mRNAs, a non-canonical splicing process promoted by dsRNA structures across circularizing exons (By similarity). Promotes formation of phase-separated membraneless compartments, such as P-bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation (By similarity). The resulting mRNA-YTHDF complexes then partition into different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules (By similarity). May also recognize and bind N1-methyladenosine (m1A)-containing mRNAs: inhibits trophoblast invasion by binding to m1A-methylated transcripts of IGF1R, promoting their degradation (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q3UVI5;Q6NXJ6;Q6NXJ8;Q8BKB6", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0043022 ribosome binding;GO:1990247 N6-methyladenosine-containing RNA reader activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000932 P-body;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0043488 regulation of mRNA stability;GO:0045727 positive regulation of translation;GO:0034063 stress granule assembly;GO:0061157 mRNA destabilization;GO:0070925 organelle assembly", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "Q8BYK6-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BZ94-1", "uniprot_id": [ { "id": "ZMAT4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BZ94", "type": "external" } ], "mass": 25671.0, "length": 229, "protein_name": "Zinc finger matrin-type protein 4", "gene_name": "Zmat4", "organism": "Mouse", "refseq_name": "zinc finger matrin-type protein 4 isoform 2", "refseq_ac": [ { "id": "NP_001264168", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264168", "type": "external" } ], "gene_names_uniprotkb": "Zmat4", "gene_names_refseq": "9630048M01Rik; Zmat4", "protein_names_uniprotkb": "Zinc finger matrin-type protein 4", "protein_names_refseq": "zinc finger matrin-type protein 4 isoform 2; zinc finger matrin-type protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:320158)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3USG2;Q6AXC5", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BZ94-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C407-1", "uniprot_id": [ { "id": "YIPF4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C407", "type": "external" } ], "mass": 27283.0, "length": 246, "protein_name": "Protein YIPF4", "gene_name": "Yipf4", "organism": "Mouse", "refseq_name": "protein YIPF4", "refseq_ac": [ { "id": "NP_080693", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080693", "type": "external" } ], "gene_names_uniprotkb": "Yipf4", "gene_names_refseq": "2310034L04Rik; Yipf4", "protein_names_uniprotkb": "Protein YIPF4; YIP1 family member 4", "protein_names_refseq": "protein YIPF4", "tax_id": 10090, "disease": "", "pathway": " (mmu:67864)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25428506;30084848", "class_list": "", "function": "Involved in the maintenance of the Golgi structure., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99KZ9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0048280 vesicle fusion with Golgi apparatus", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8C407-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C6P8-1", "uniprot_id": [ { "id": "ZFP57_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C6P8", "type": "external" } ], "mass": 47959.0, "length": 421, "protein_name": "Zinc finger protein 57", "gene_name": "Zfp57", "organism": "Mouse", "refseq_name": "zinc finger protein 57 isoform 1", "refseq_ac": [ { "id": "NP_001013767", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013767", "type": "external" } ], "gene_names_uniprotkb": "Zfp57", "gene_names_refseq": "G19; Zfp-57; Zfp57", "protein_names_uniprotkb": "Zinc finger protein 57; Zfp-57", "protein_names_refseq": "zinc finger protein 57 isoform 1", "tax_id": 10090, "disease": "transient neonatal diabetes mellitus 1 (Disease Ontology:DOID:0061173)", "pathway": " (mmu:22715)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "14732407;15070898;15845352;17938240;18622393;18854139;21750661;23059534;28135057;30602440;36004502;8120052", "class_list": "", "function": "Maternal and zygotic ZFP57 regulate coronary vascular formation and myocardium maturation in mouse embryo., [RefSeq, PubMed]; Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs) (PubMed:15070898, PubMed:18854139, PubMed:23059534, PubMed:30602440). Acts together with ZNF445, but ZFP57 plays the predominant role in imprinting maintenance. In contrast, in humans, ZNF445 seems to be the major factor early embryonic imprinting maintenance (PubMed:30602440). Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells. Binds to a 5'-TGCCGC-3' consensus sequence and recognizes the methylated CpG within this element (PubMed:15070898, PubMed:18854139, PubMed:23059534)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Zpf57 maintains both maternal and paternal genomic imprints., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UT94;Q62515;Q6JPI1", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000792 heterochromatin", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0071514 genomic imprinting;GO:0044726 epigenetic programing of female pronucleus;GO:0044027 negative regulation of gene expression via chromosomal CpG island methylation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8C6P8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C8V1-1", "uniprot_id": [ { "id": "ZXDC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C8V1", "type": "external" } ], "mass": 90755.0, "length": 858, "protein_name": "Zinc finger protein ZXDC", "gene_name": "Zxdc", "organism": "Mouse", "refseq_name": "zinc finger protein ZXDC isoform 1", "refseq_ac": [ { "id": "NP_084536", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084536", "type": "external" } ], "gene_names_uniprotkb": "Zxdc", "gene_names_refseq": "A930012H20; B930086F11Rik; Zxdc", "protein_names_uniprotkb": "Zinc finger protein ZXDC", "protein_names_refseq": "zinc finger protein ZXDC isoform 1; zinc finger protein ZXDC", "tax_id": 10090, "disease": "", "pathway": " (mmu:80292)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25428506;30084848", "class_list": "", "function": "Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TEP2;Q3URC2;Q8C4U7;Q8C4Z9;Q8C8C2;Q8C8T1;Q99J65", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0003712 transcription coregulator activity;GO:0030275 LRR domain binding;GO:0070742 C2H2 zinc finger domain binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8C8V1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CAV0-1", "uniprot_id": [ { "id": "YBEY_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CAV0", "type": "external" } ], "mass": 18989.0, "length": 164, "protein_name": "Endoribonuclease YbeY", "gene_name": "Ybey", "organism": "Mouse", "refseq_name": "endoribonuclease YbeY", "refseq_ac": [ { "id": "NP_766138", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766138", "type": "external" } ], "gene_names_uniprotkb": "Ybey", "gene_names_refseq": "1110068N23Rik; A130042E20Rik; C21orf57; ORF57; ORF66; Ybey", "protein_names_uniprotkb": "Endoribonuclease YbeY; 3.1.-.-", "protein_names_refseq": "endoribonuclease YbeY; putative metalloprotease C21orf57 homolog; putative ribonuclease; rRNA maturation factor homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:216119)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "31219806", "class_list": "", "function": "Single strand-specific metallo-endoribonuclease involved in rRNA maturation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UW80;Q6PG17", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding;GO:0004521 RNA endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion", "go_biological_process": "GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8CAV0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CJ78-1", "uniprot_id": [ { "id": "ZN628_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CJ78", "type": "external" } ], "mass": 109047.0, "length": 1038, "protein_name": "Zinc finger protein 628", "gene_name": "Znf628", "organism": "Mouse", "refseq_name": "zinc finger protein 628 isoform 1", "refseq_ac": [ { "id": "NP_739565", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_739565", "type": "external" } ], "gene_names_uniprotkb": "Znf628; Zec; Zfp628", "gene_names_refseq": "Zec; Zfp628; Znf628", "protein_names_uniprotkb": "Zinc finger protein 628; Zinc finger protein expressed in embryonal cells and certain adult organs", "protein_names_refseq": "zinc finger protein 628 isoform 1; zinc finger protein Zec; zinc finger protein expressed in embryonal cells and certain adult organs", "tax_id": 10090, "disease": "", "pathway": " (mmu:232816)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15556296;20485683;31932482;35820727", "class_list": "", "function": "These data identify ZFP628 as a novel transcriptional regulator of stage-specific spermatogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptional activator (PubMed:15556296, PubMed:31932482). Binds DNA on GT-box consensus sequence 5'-TTGGTT-3' (PubMed:15556296). Plays a role in spermiogenesis (PubMed:31932482)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 0, "predicted_o_glycosites": 6, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q3U2L5;Q6P5B3", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8CJ78-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R121-1", "uniprot_id": [ { "id": "ZPI_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R121", "type": "external" } ], "mass": 51797.0, "length": 448, "protein_name": "Protein Z-dependent protease inhibitor", "gene_name": "Serpina10", "organism": "Mouse", "refseq_name": "protein Z-dependent protease inhibitor isoform 2 precursor", "refseq_ac": [ { "id": "NP_001288333", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001288333", "type": "external" } ], "gene_names_uniprotkb": "Serpina10; Zpi", "gene_names_refseq": "PZI; Serpina10; ZPI", "protein_names_uniprotkb": "Protein Z-dependent protease inhibitor; PZ-dependent protease inhibitor; PZI; Serpin A10", "protein_names_refseq": "PZ-dependent protease inhibitor; protein Z-dependent protease inhibitor isoform 2 precursor; protein Z-dependent protease inhibitor; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10", "tax_id": 10090, "disease": "small intestine carcinoid neuroendocrine tumor (Disease Ontology:DOID:0050925); thrombophilia (Disease Ontology:DOID:2452)", "pathway": " (mmu:217847); (R-MMU-381426); (R-MMU-8957275); (R-MMU-9769739)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;11372680;16944957;17330941;18344422;22786881;23205927;23530052;25428506", "class_list": "", "function": "Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids. Also inhibits factor XIa in the absence of cofactors (By similarity)., [UniProtKB]; Letter: ZPI is a typical acute phase reactant., [RefSeq, PubMed]; PZ and ZPI deficiency would be associated with a modest thrombotic risk with ZPI deficiency producing a more severe phenotype., [RefSeq, PubMed]; Structural features within residues of the 39-loop contribute to the resistance of FIXa to inhibition by plasma inhibitors ZPI and TFPI., [RefSeq, PubMed]; The protein encoded by this gene is a member of the large serpin family of proteins, and is also known as serpin PZ-dependent protease inhibitor (ZPI or PZI). This protein is thought to play an important role in the regulation of coagulation. It directly inhibits factor XIa, and also inhibits factor Xa in the presence of calcium, phospholipids, and protein Z (PZ). Deficiencies in this gene lead to an increase in thrombosis. Alternative splicing results in multiple transcript variants that encode multiple protein isoforms. [provided by RefSeq, Aug 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8VCV8", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0008201 heparin binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007596 blood coagulation;GO:0097421 liver regeneration", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8R121-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VD12-1", "uniprot_id": [ { "id": "Z385A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VD12", "type": "external" } ], "mass": 40447.0, "length": 386, "protein_name": "Zinc finger protein 385A", "gene_name": "Zfp385a; Znf385a", "organism": "Mouse", "refseq_name": "zinc finger protein 385A isoform 1", "refseq_ac": [ { "id": "NP_038894", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038894", "type": "external" } ], "gene_names_uniprotkb": "Zfp385a; Znf385a; Hzf; Zfp385a", "gene_names_refseq": "Hzf; Zfp385a; Zfp385; Znf385a", "protein_names_uniprotkb": "Zinc finger protein 385A; Hematopoietic zinc finger protein", "protein_names_refseq": "hematopoietic zinc finger protein; zinc finger protein 385A isoform 1; zinc finger protein 385", "tax_id": 10090, "disease": "", "pathway": " (mmu:29813); (R-MMU-6804759); (R-MMU-69895)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10585558;11927637;16286649;16382142;17383763;17719541;18418387;21402775;21750661;25821909;34203471;34428180", "class_list": "", "function": "DISC1 binds ITPR1 mRNA with HZF, thereby regulating its dendritic transport for synaptic plasticity., [RefSeq, PubMed]; Hzf is an RNA-binding protein that controls the dendritic mRNA localization and activity-dependent translation of type 1 inositol 1,4,5-trisphosphate receptor mRNA, a process that is impaired in Hzf mutant mice, [RefSeq, PubMed]; Hzf is essential for megakaryopoiesis and hemostasis in vivo, [RefSeq, PubMed]; In the present study we demonstrated that mice lacking Hzf (Hzf(-/-) mice) exhibited severe impairments of motor coordination and cerebellum-dependent motor learning., [RefSeq, PubMed]; RNA-binding protein that affects the localization and the translation of a subset of mRNA. May play a role in adipogenesis through binding to the 3'-UTR of CEBPA mRNA and regulation of its translation. Targets ITPR1 mRNA to dendrites in Purkinje cells, and may regulate its activity-dependent translation. With ELAVL1, binds the 3'-UTR of p53/TP53 mRNAs to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind CCNB1 mRNA. Alternatively, may also regulate p53/TP53 activity through direct protein-protein interaction. Interacts with p53/TP53 and promotes cell-cycle arrest over apoptosis enhancing preferentially the DNA binding and transactivation of p53/TP53 on cell-cycle arrest target genes over proapoptotic target genes. May also regulate the ubiquitination and stability of CDKN1A promoting DNA damage-induced cell cycle arrest. Also plays a role in megakaryocytes differentiation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "G3UWA5;Q9QY68", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003730 mRNA 3'-UTR binding;GO:0002039 p53 binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:2000765 regulation of cytoplasmic translation;GO:0010609 mRNA localization resulting in post-transcriptional regulation of gene expression;GO:0006351 DNA-templated transcription;GO:0006915 apoptotic process;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8VD12-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VIG0-1", "uniprot_id": [ { "id": "ZCH14_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VIG0", "type": "external" } ], "mass": 99835.0, "length": 956, "protein_name": "Zinc finger CCHC domain-containing protein 14", "gene_name": "Zcchc14", "organism": "Mouse", "refseq_name": "zinc finger CCHC domain-containing protein 14 isoform 1", "refseq_ac": [ { "id": "NP_543131", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_543131", "type": "external" } ], "gene_names_uniprotkb": "Zcchc14; Kiaa0579", "gene_names_refseq": "BDG29; Zcchc14", "protein_names_uniprotkb": "Zinc finger CCHC domain-containing protein 14; BDG-29", "protein_names_refseq": "BDG-29 protein; zinc finger CCHC domain-containing protein 14 isoform 1; zinc finger CCHC domain-containing protein 14", "tax_id": 10090, "disease": "", "pathway": " (mmu:142682)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;21750661;22517741;25428506;30084848;31219806;32782141;32848054;34428180;36852467;40885482", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q80TX3;Q91VU4", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q8VIG0-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000001000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91X45-1", "uniprot_id": [ { "id": "ZBTB3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91X45", "type": "external" } ], "mass": 55901.0, "length": 518, "protein_name": "Zinc finger and BTB domain-containing protein 3", "gene_name": "Zbtb3", "organism": "Mouse", "refseq_name": "zinc finger and BTB domain-containing protein 3", "refseq_ac": [ { "id": "NP_001091707", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091707", "type": "external" } ], "gene_names_uniprotkb": "Zbtb3", "gene_names_refseq": "4930563M09Rik; Zbtb3", "protein_names_uniprotkb": "Zinc finger and BTB domain-containing protein 3", "protein_names_refseq": "zinc finger and BTB domain-containing protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:75291)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "31219806", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UQP3;Q8BIJ4", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q91X45-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91XB7-1", "uniprot_id": [ { "id": "YIF1A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91XB7", "type": "external" } ], "mass": 32134.0, "length": 293, "protein_name": "Protein YIF1A", "gene_name": "Yif1a", "organism": "Mouse", "refseq_name": "protein YIF1A", "refseq_ac": [ { "id": "NP_080829", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080829", "type": "external" } ], "gene_names_uniprotkb": "Yif1a", "gene_names_refseq": "5330422J23Rik; 54TM; Yif1a; Yif1p; Yif1", "protein_names_uniprotkb": "Protein YIF1A; YIP1-interacting factor homolog A", "protein_names_refseq": "homolog of yeast Golgi membrane protein Yif1p (Yip1p-interacting factor); protein YIF1A; putative transmembrane protein", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:68090)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "18299400;19224205;20173027;20484733;21750661;21952136;25428506;25428507;25605945;27802388;30084848;30779550;33649389;34428180", "class_list": "", "function": "Has a role in transport between endoplasmic reticulum and Golgi., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Possible role in transport between endoplasmic reticulum and Golgi., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CWB2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0005789 endoplasmic reticulum membrane;GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane", "go_biological_process": "GO:0015031 protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q91XB7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q922H9-1", "uniprot_id": [ { "id": "ZN330_MOUSE", "url": "https://www.uniprot.org/uniprot/Q922H9", "type": "external" } ], "mass": 35608.0, "length": 316, "protein_name": "Zinc finger protein 330", "gene_name": "Zfp330; Znf330", "organism": "Mouse", "refseq_name": "zinc finger protein 330 isoform 1", "refseq_ac": [ { "id": "NP_663575", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663575", "type": "external" } ], "gene_names_uniprotkb": "Zfp330; Znf330; Noa36; Zfp330", "gene_names_refseq": "Noa36; Noazfp; Zfp330; Znf330", "protein_names_uniprotkb": "Zinc finger protein 330; Nucleolar autoantigen 36; Nucleolar cysteine-rich protein", "protein_names_refseq": "nucleolar autoantigen 36; nucleolar cysteine-rich protein; zinc finger protein 330 isoform 1; zinc finger protein 330", "tax_id": 10090, "disease": "", "pathway": " (mmu:30932)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21183079;21750661;37828378", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C389;Q8K2M4", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0000775 chromosome, centromeric region;GO:0030496 midbody", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q922H9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99LW6-1", "uniprot_id": [ { "id": "YAF2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99LW6", "type": "external" } ], "mass": 19655.0, "length": 179, "protein_name": "YY1-associated factor 2", "gene_name": "Yaf2", "organism": "Mouse", "refseq_name": "YY1-associated factor 2", "refseq_ac": [ { "id": "NP_077151", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077151", "type": "external" } ], "gene_names_uniprotkb": "Yaf2", "gene_names_refseq": "2810021M11Rik; Yaf2", "protein_names_uniprotkb": "YY1-associated factor 2", "protein_names_refseq": "YY1-associated factor 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:67057); (R-MMU-8939243); (R-MMU-8953750)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "14557078;19960508;21183079;32203418;37935677", "class_list": "", "function": "Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in chromatin-remodeling., [UniProtKB]; Functional dissection of PRC1 subunits RYBP and YAF2 during neural differentiation of embryonic stem cells. Publication Status: Online-Only, [RefSeq, PubMed]; The results suggest that histone H1-dependent chromatin compaction plays a critical role in the stable propagation of H2AK119ub1 by RYBP/YAF2-PRC1 during cell division., [RefSeq, PubMed]; Yaf2 acts as a functional, likely molecular, link between YY1 and the Polycomb proteins. It is proposed to mediate the DNA binding activity of YY1 and recruitment of Polycomb proteins to the regulatory region of target genes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UFD4;Q9DBE4", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q99LW6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CPV7-1", "uniprot_id": [ { "id": "ZDHC6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CPV7", "type": "external" } ], "mass": 47527.0, "length": 413, "protein_name": "Palmitoyltransferase ZDHHC6", "gene_name": "Zdhhc6", "organism": "Mouse", "refseq_name": "palmitoyltransferase ZDHHC6 isoform 1", "refseq_ac": [ { "id": "NP_001028745", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028745", "type": "external" } ], "gene_names_uniprotkb": "Zdhhc6", "gene_names_refseq": "2400007G07Rik; 5930409M18Rik; DHHC-6; Zdhhc6", "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC6; 2.3.1.-; 2.3.1.225; DHHC-6; Stearoyltransferase ZDHHC6; Zinc finger DHHC domain-containing protein 6", "protein_names_refseq": "H4 homolog; palmitoyltransferase ZDHHC6 isoform 1; palmitoyltransferase ZDHHC6; stearoyltransferase ZDHHC6; zinc finger DHHC domain-containing protein 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:66980)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "18299400;19224205;20173027;21750661;21952136;25368151;25428506;25605945;28826475;30084848;34428180;35820727;36548985;37828378", "class_list": "", "function": "Astrocyte Elevated Gene-1 Cys75 S-Palmitoylation by ZDHHC6 Regulates Its Biological Activity., [RefSeq, PubMed]; Endoplasmic reticulum palmitoyl acyltransferase that mediates palmitoylation of proteins such as AMFR, CALX, ITPR1 and TFRC (PubMed:25368151). Palmitoylates calnexin (CALX), which is required for its association with the ribosome-translocon complex and efficient folding of glycosylated proteins (By similarity). Mediates palmitoylation of AMFR, promoting AMFR distribution to the peripheral endoplasmic reticulum (By similarity). Together with SELENOK, palmitoylates ITPR1 in immune cells, leading to regulate ITPR1 stability and function (PubMed:25368151). Stearoyltransferase that mediates stearoylation of TFRC to inhibit TFRC-mediated activation of the JNK pathway and mitochondrial fragmentation (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U3I8;Q3UT70;Q544H1", "ec_number_list": [ { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" }, { "id": "6.3.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.1.2", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0019706 protein-cysteine S-palmitoyltransferase activity;GO:0016409 palmitoyltransferase activity;GO:0140439 protein-cysteine S-stearoyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0006612 protein targeting to membrane;GO:0018345 protein palmitoylation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9CPV7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQG3-1", "uniprot_id": [ { "id": "ZMY19_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQG3", "type": "external" } ], "mass": 26433.0, "length": 227, "protein_name": "Zinc finger MYND domain-containing protein 19", "gene_name": "Zmynd19", "organism": "Mouse", "refseq_name": "zinc finger MYND domain-containing protein 19 isoform 1", "refseq_ac": [ { "id": "NP_080297", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080297", "type": "external" } ], "gene_names_uniprotkb": "Zmynd19; Mizip", "gene_names_refseq": "2700064H14Rik; Zmynd19; mizip", "protein_names_uniprotkb": "Zinc finger MYND domain-containing protein 19; MCH-R1-interacting zinc finger protein; Melanin-concentrating hormone receptor 1-interacting zinc finger protein", "protein_names_refseq": "MCH-R1-interacting zinc finger protein; melanin concentrating hormone receptor interacting zinc finger protein; melanin-concentrating hormone receptor 1-interacting zinc finger protein; zinc finger MYND domain-containing protein 19 isoform 1; zinc finger MYND domain-containing protein 19", "tax_id": 10090, "disease": "", "pathway": " (mmu:67187)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12208518;15950311;18299400;21952136;25428506;25428507;25605945;30084848;30779550;34428180", "class_list": "", "function": "Data support the notion that MIZIP might interact with melanin-concentrating hormone receptor 1 (MCHR1) in a cell type specific manner in vivo, suggesting a role in the regulation of MCH signalling in distinct regions of the mammalian brain, [RefSeq, PubMed]; May be involved as a regulatory molecule in GPR24/MCH-R1 signaling., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K1T3", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0045202 synapse", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9CQG3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQW1-1", "uniprot_id": [ { "id": "YKT6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQW1", "type": "external" } ], "mass": 22314.0, "length": 198, "protein_name": "Synaptobrevin homolog YKT6", "gene_name": "Ykt6", "organism": "Mouse", "refseq_name": "synaptobrevin homolog YKT6", "refseq_ac": [ { "id": "NP_062635", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062635", "type": "external" } ], "gene_names_uniprotkb": "Ykt6", "gene_names_refseq": "0610042I15Rik; 1810013M05Rik; Ykt6", "protein_names_uniprotkb": "Synaptobrevin homolog YKT6; 2.3.1.-", "protein_names_refseq": "YKT6 homolog; prenylated SNARE protein (Ykt6); synaptobrevin homolog YKT6", "tax_id": 10090, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888)", "pathway": " (mmu:56418); (R-MMU-204005); (R-MMU-6807878); (R-MMU-6811438); (R-MMU-8980692); (R-MMU-9013148); (R-MMU-9013149); (R-MMU-9013408); (R-MMU-9013423)", "pathway_count": 9, "publication_count": 2, "publication_id_list": "11323436;31599954", "class_list": "", "function": "Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment (By similarity). Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5 (By similarity). Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5 (By similarity). Has a S-palmitoyl transferase activity (By similarity). Essential for the structural and functional organization of the Golgi apparatus (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88595", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "1.3.1.70", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.70", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" } ], "go_molecular_function": "GO:0005484 SNAP receptor activity;GO:0019706 protein-cysteine S-palmitoyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005768 endosome;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0015031 protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0042147 retrograde transport, endosome to Golgi;GO:0006903 vesicle targeting;GO:0006904 vesicle docking involved in exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CQW1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CWB7-1", "uniprot_id": [ { "id": "YD286_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CWB7", "type": "external" } ], "mass": 13430.0, "length": 115, "protein_name": "Glutaredoxin-like protein C5orf63 homolog", "gene_name": "", "organism": "Mouse", "refseq_name": "glutaredoxin-like protein C5orf63 homolog", "refseq_ac": [ { "id": "NP_084185", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084185", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "C330018D20Rik", "protein_names_uniprotkb": "Glutaredoxin-like protein C5orf63 homolog", "protein_names_refseq": "glutaredoxin-like protein C5orf63 homolog; glutaredoxin-like protein YDR286C homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:77422)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9CWB7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CWQ2-1", "uniprot_id": [ { "id": "ZSWM7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CWQ2", "type": "external" } ], "mass": 16658.0, "length": 152, "protein_name": "Zinc finger SWIM domain-containing protein 7", "gene_name": "Zswim7", "organism": "Mouse", "refseq_name": "zinc finger SWIM domain-containing protein 7", "refseq_ac": [ { "id": "NP_081474", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081474", "type": "external" } ], "gene_names_uniprotkb": "Zswim7; Sws1", "gene_names_refseq": "2410012H22Rik; SWS1; Zswim7", "protein_names_uniprotkb": "Zinc finger SWIM domain-containing protein 7; SWIM domain-containing and Srs2-interacting protein 1 homolog", "protein_names_refseq": "SWIM domain-containing and Srs2-interacting protein 1 homolog; zinc finger SWIM domain-containing protein 7", "tax_id": 10090, "disease": "ovarian dysgenesis 10 (Disease Ontology:DOID:0061014); spermatogenic failure 71 (Disease Ontology:DOID:0070570)", "pathway": " (mmu:69747)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16710300;30305635;33713115;34253720", "class_list": "", "function": "Distinct pathways of homologous recombination controlled by the SWS1-SWSAP1-SPIDR complex. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in early stages DNA double-strand break (DSB) repair via homologous recombination (HR) (PubMed:30305635, PubMed:34253720). Forms a heterodimeric complex with ZSWIM7/SWS1 that promotes HR by regulating replication protein-A (RPA) dynamics on single-stranded DNA, thereby stabilizing RAD51 and DMC1 filaments on DNA (PubMed:34253720). The SWSAP1-ZSWIM7/SWS1 heterodimer is essential during meiosis by stabilizing DMC1 filaments (PubMed:30305635, PubMed:33713115, PubMed:34253720). In contrast, it is critical for only certain types of homologous-directed DNA repair, such as inter-homolog homologous recombination (IR-HR) (PubMed:34253720). IR-HR is a DNA repair mechanism where a cell repairs a DSB on one chromosome using the matching homologous chromosome as a template, rather than the sister chromatid (PubMed:34253720)., [UniProtKB, PubMed, PubMed, PubMed]; These results demonstrate an essential role for SWS1-SWSAP1 in meiotic progression and emphasize the complex interplay of factors that ensure recombinase function. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0097196 Shu complex", "go_biological_process": "GO:0050821 protein stabilization;GO:0000724 double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9CWQ2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CZA5-1", "uniprot_id": [ { "id": "ZCH12_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CZA5", "type": "external" } ], "mass": 45107.0, "length": 402, "protein_name": "Zinc finger CCHC domain-containing protein 12", "gene_name": "Zcchc12", "organism": "Mouse", "refseq_name": "zinc finger CCHC domain-containing protein 12", "refseq_ac": [ { "id": "NP_082601", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082601", "type": "external" } ], "gene_names_uniprotkb": "Zcchc12; Sizn1", "gene_names_refseq": "2810028A01Rik; Sizn1; Zcchc12", "protein_names_uniprotkb": "Zinc finger CCHC domain-containing protein 12; Smad-interacting zinc finger protein 1", "protein_names_refseq": "smad-interacting zinc finger protein 1; zinc finger CCHC domain-containing protein 12", "tax_id": 10090, "disease": "", "pathway": " (mmu:72693)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "18160706;19578717", "class_list": "", "function": "Transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It contributes to the BMP-induced enhancement of cholinergic-neuron-specific gene expression., [UniProtKB, PubMed]; ZCCHC12 enhanced the transcriptional activities of activator protein 1 (AP-1) and cAMP response element binding protein (CREB) as a coactivator, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding;GO:0032183 SUMO binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0016605 PML body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0030509 BMP signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CZA5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CZV2-1", "uniprot_id": [ { "id": "SHLD3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CZV2", "type": "external" } ], "mass": 29675.0, "length": 255, "protein_name": "Shieldin complex subunit 3", "gene_name": "Shld3", "organism": "Mouse", "refseq_name": "shieldin complex subunit 3", "refseq_ac": [ { "id": "NP_001352267", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001352267", "type": "external" } ], "gene_names_uniprotkb": "Shld3; Rinn1", "gene_names_refseq": "Rinn1; Shld3", "protein_names_uniprotkb": "Shieldin complex subunit 3; REV7-interacting novel NHEJ regulator 1", "protein_names_refseq": "REV7-interacting novel NHEJ regulator 1; shieldin complex subunit 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:113002583)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. 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Required for the interaction of R2TP complex subunit RPAP3 and prefoldin-like subunit URI1 with U5 snRNP proteins EFTUD2 and PRPF8 (By similarity). 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Publication Status: Online-Only, [RefSeq, PubMed]; Duox1 is the main source of H(2)O(2) in the rat thyroid cell line PCCl3., [RefSeq, PubMed]; Generates hydrogen peroxide (H2O2) which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO (By similarity). Plays a role in thyroid hormone synthesis (By similarity). Also required for lactoperoxidase-mediated antimicrobial defense at the surface of mucosa (By similarity). Antimicrobial agent hypothiocyanite (OSCN-), which is produced by LPO from DUOX1-derived H2O2, promotes influenza virus inactivation by reducing viral binding to and entry into host cells (By similarity). Promotes antiviral immunity by increasing airway cytokine levels, promoting innate immune cell recruitment and reducing airway epithelial cell apoptosis (PubMed:34168077). In response to bacterial stimuli, activated by ATP and promotes EGFR/ERK signaling, ADAM17 activation, and EGFR ligand shedding, leading to enhanced CXCL8/IL8 expression and secretion in airway epithelia (By similarity). Synthesizes NAADP from its reduced NAADPH form which promotes Ca(2+) signaling during T cell activation (By similarity). In addition to its oxidase activity, has also been shown to have peroxidase activity through its N-terminal peroxidase-like domain (By similarity). 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A1D5RM15-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5RMH6-1", "uniprot_id": [ { "id": "A0A1D5RMH6_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A1D5RMH6", "type": "external" } ], "mass": 35055.0, "length": 312, "protein_name": "Olfactory receptor", "gene_name": "Or7g23", "organism": "Mouse", "refseq_name": "olfactory receptor family 7 subfamily G member 23", "refseq_ac": [ { "id": "NP_001423207", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001423207", "type": "external" } ], "gene_names_uniprotkb": "Or7g23; Olfr839", "gene_names_refseq": "MOR152-4P; Olfr839-ps1; Olfr839; Or7g23", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2PVTD-12912534-12911542; olfactory receptor 839, pseudogene 1; olfactory receptor MOR152-4P; olfactory receptor family 7 subfamily G member 23", "tax_id": 10090, "disease": "", "pathway": " (mmu:258184)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A1D5RMH6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1W2P855-1", "uniprot_id": [ { "id": "A0A1W2P855_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A1W2P855", "type": "external" } ], "mass": 92154.0, "length": 802, "protein_name": "Cell division cycle 5-like protein", "gene_name": "Cdc5lrt8", "organism": "Mouse", "refseq_name": "cell division cycle 5-like protein", "refseq_ac": [ { "id": "XP_036012054", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_036012054", "type": "external" } ], "gene_names_uniprotkb": "Cdc5lrt8; Gm9046", "gene_names_refseq": "Cdc5lrt8", "protein_names_uniprotkb": "Cell division cycle 5-like protein; Cdc5-like protein", "protein_names_refseq": "cell division cycle 5-like protein", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); osteosarcoma (Disease Ontology:DOID:3347); esophagus adenocarcinoma (Disease Ontology:DOID:4914)", "pathway": " (mmu:668209)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0043522 leucine zipper domain binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006281 DNA repair;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:1990090 cellular response to nerve growth factor stimulus;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A1W2P855-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A286YE43-1", "uniprot_id": [ { "id": "A0A286YE43_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A286YE43", "type": "external" } ], "mass": 33139.0, "length": 300, "protein_name": "Predicted gene, 47996", "gene_name": "Gm47996", "organism": "Mouse", "refseq_name": "uncharacterized protein Gm47996", "refseq_ac": [ { "id": "XP_036012040", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_036012040", "type": "external" } ], "gene_names_uniprotkb": "Gm47996", "gene_names_refseq": "Gm47996", "protein_names_uniprotkb": "Predicted gene, 47996", "protein_names_refseq": "uncharacterized protein Gm47996", "tax_id": 10090, "disease": "", "pathway": " (mmu:118567805)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A286YE43-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AK60-1", "uniprot_id": [ { "id": "A2AK60_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AK60", "type": "external" } ], "mass": 35532.0, "length": 313, "protein_name": "Olfactory receptor family 8 subfamily K member 30", "gene_name": "Or8k30", "organism": "Mouse", "refseq_name": "olfactory receptor 1076", "refseq_ac": [ { "id": "NP_666518", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666518", "type": "external" } ], "gene_names_uniprotkb": "Or8k30; Olfr1076", "gene_names_refseq": "MOR189-2; Olfr1076; Or8k30", "protein_names_uniprotkb": "Olfactory receptor family 8 subfamily K member 30", "protein_names_refseq": "GA_x6K02T2Q125-47993761-47994702; olfactory receptor 1076; olfactory receptor MOR189-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:258401)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2AK60-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2ARR7-1", "uniprot_id": [ { "id": "A2ARR7_MOUSE", "url": "https://www.uniprot.org/uniprot/A2ARR7", "type": "external" } ], "mass": 60927.0, "length": 526, "protein_name": "Predicted gene 14412", "gene_name": "Gm14412", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gm14412", "gene_names_refseq": "", "protein_names_uniprotkb": "Predicted gene 14412", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-212436)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2ARR7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1AQA8-1", "uniprot_id": [ { "id": "B1AQA8_MOUSE", "url": "https://www.uniprot.org/uniprot/B1AQA8", "type": "external" } ], "mass": 21763.0, "length": 209, "protein_name": "Keratin associated protein 4-8", "gene_name": "Krtap4-8", "organism": "Mouse", "refseq_name": "keratin associated protein 4 family member", "refseq_ac": [ { "id": "NP_001079016", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001079016", "type": "external" } ], "gene_names_uniprotkb": "Krtap4-8", "gene_names_refseq": "Krtap4-8", "protein_names_uniprotkb": "Keratin associated protein 4-8", "protein_names_refseq": "keratin associated protein 4 family member", "tax_id": 10090, "disease": "", "pathway": " (mmu:665992); 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The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0045095 keratin filament", "go_biological_process": "GO:0042633 hair cycle", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B1AQA8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z3Y1-1", "uniprot_id": [ { "id": "D3Z3Y1_MOUSE", "url": "https://www.uniprot.org/uniprot/D3Z3Y1", "type": "external" } ], "mass": 108513.0, "length": 983, "protein_name": "Phosphatidylinositol glycan anchor biosynthesis, class G", "gene_name": "Pigg", "organism": "Mouse", "refseq_name": "GPI ethanolamine phosphate transferase 2 isoform 1", "refseq_ac": [ { "id": "NP_001297618", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297618", "type": "external" } ], "gene_names_uniprotkb": "Pigg", "gene_names_refseq": "Gpi7; Pigg", "protein_names_uniprotkb": "Phosphatidylinositol glycan anchor biosynthesis, class G", "protein_names_refseq": "GPI ethanolamine phosphate transferase 2 isoform 1; GPI ethanolamine phosphate transferase 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:433931); (R-MMU-162710)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;21750661", "class_list": "glycogene", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 43, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051377 mannose-ethanolamine phosphotransferase activity;GO:0051267 CP2 mannose-ethanolamine phosphotransferase activity;GO:0016740 transferase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006506 GPI anchor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "D3Z3Y1-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1000000000000.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3YZF6-1", "uniprot_id": [ { "id": "D3YZF6_MOUSE", "url": "https://www.uniprot.org/uniprot/D3YZF6", "type": "external" } ], "mass": 146615.0, "length": 1314, "protein_name": "Spermatogenesis associated 31 subfamily F member 1A", "gene_name": "Spata31f1a", "organism": "Mouse", "refseq_name": "Fam205a1 protein", "refseq_ac": [ { "id": "NP_001264096", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264096", "type": "external" } ], "gene_names_uniprotkb": "Spata31f1a; Fam205a1; Gm12429", "gene_names_refseq": "Fam205a1; Gm12394; Gm12429; Spata31f1a", "protein_names_uniprotkb": "Spermatogenesis associated 31 subfamily F member 1A", "protein_names_refseq": "Fam205a1 protein; family with sequence similarity 205, member A1; protein FAM205A-2-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:433698)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3YZF6-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PVR6-1", "uniprot_id": [ { "id": "E9PVR6_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PVR6", "type": "external" } ], "mass": 34426.0, "length": 306, "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r1", "organism": "Mouse", "refseq_name": "vomeronasal type-1 receptor A16", "refseq_ac": [ { "id": "NP_001160200", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160200", "type": "external" } ], "gene_names_uniprotkb": "Vmn1r1", "gene_names_refseq": "EG625823; Gm6628; Vmn1r1", "protein_names_uniprotkb": "Vomeronasal type-1 receptor", "protein_names_refseq": "vomernasal 1 receptor Vmn1r1; vomeronasal type-1 receptor A16", "tax_id": 10090, "disease": "", "pathway": " (mmu:625823)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005550 pheromone binding;GO:0016503 pheromone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9PVR6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F8VQK6-1", "uniprot_id": [ { "id": "F8VQK6_MOUSE", "url": "https://www.uniprot.org/uniprot/F8VQK6", "type": "external" } ], "mass": 77701.0, "length": 707, "protein_name": "F-box and leucine-rich repeat protein 18", "gene_name": "Fbxl18", "organism": "Mouse", "refseq_name": "F-box/LRR-repeat protein 18", "refseq_ac": [ { "id": "NP_001028484", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028484", "type": "external" } ], "gene_names_uniprotkb": "Fbxl18", "gene_names_refseq": "B130019G13Rik; C330021B20Rik; Fbxl18", "protein_names_uniprotkb": "F-box and leucine-rich repeat protein 18", "protein_names_refseq": "F-box/LRR-repeat protein 18", "tax_id": 10090, "disease": "", "pathway": " (mmu:231863)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;21750661;25605945;27890708;30779550;37378633", "class_list": "", "function": "Elevated FBXL18 promotes RPS15A ubiquitination and SMAD3 activation to drive HCC. Publication Status: Online-Only, [RefSeq, PubMed]; Study showed that LRRK2 phosphorylation is required for LRRK2 to bind to Fbxl18, and that this interaction is important for regulating the amount of LRRK2 via ubiquitination of LRRK2 by the SCFFbxl18 ubiquitin ligase and subsequent proteasomal degradation of LRRK2. We also show that LRRK2 can induce caspase 8 mediated cell death and that the degradation of LRRK2 mediated by Fbxl18 can prevent LRRK2-mediated toxicity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "F8VQK6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PZ36-1", "uniprot_id": [ { "id": "PKHD1_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PZ36", "type": "external" } ], "mass": 444882.0, "length": 4059, "protein_name": "Fibrocystin", "gene_name": "Pkhd1", "organism": "Mouse", "refseq_name": "fibrocystin precursor", "refseq_ac": [ { "id": "NP_694819", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694819", "type": "external" } ], "gene_names_uniprotkb": "Pkhd1", "gene_names_refseq": "FPC; Pkhd1; Tigm1", "protein_names_uniprotkb": "Fibrocystin; Polycystic kidney and hepatic disease 1 protein; Polyductin", "protein_names_refseq": "TIG multiple domains 1; fibrocystin precursor; fibrocystin; polycystic kidney and hepatic disease 1 protein; polyductin; tigmin", "tax_id": 10090, "disease": "polycystic kidney disease 4 (Disease Ontology:DOID:0080212); Caroli syndrome (Disease Ontology:DOID:0081394); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861)", "pathway": " (mmu:241035)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "12191969;14983006;15647252;16243292;16956880;17470460;18202188;18235088;18286309;19959710;20048263;20875407;22021705;24586199;28154160;28729032;37419448", "class_list": "", "function": "A novel ARPKD mouse model with near-complete deletion of the Polycystic Kidney and Hepatic Disease 1 (Pkhd1) genomic locus presents with multiple phenotypes but not renal cysts., [RefSeq, PubMed]; In cultured renal cells, the PKHD1 gene product colocalized with polycystin-2, the gene product of autosomal dominant polycystic disease type 2., [RefSeq, PubMed]; Key features of human PKHD1 are highly conserved in the mouse suggesting that the complicated pattern of splicing is likely to be functionally important., [RefSeq, PubMed]; Promotes ciliogenesis in renal epithelial cells and therefore participates in the tubules formation and/or ensures the maintenance of the architecture of the lumen of the kidney (PubMed:18235088, PubMed:20875407). Has an impact on cellular symmetry by ensuring correct bipolar cell division through the regulation of centrosome duplication and mitotic spindle assembly and by maintaining oriented cell division (OCD) during tubular elongation through planar cell polarity (PCP) pathway (PubMed:19959710). During epithelial cell morphogenesis, it also regulates cell-cell and cell-matrix adhesion and participates in cell motility (By similarity). Promotes cell-cell contact through the positive regulation of PTK2 kinase activity leading to either positive regulation of epithelial cell proliferation through the HRAS/RAF1 pathways, or negative regulation of apoptosis through the PDK1/AKT1 pathway (PubMed:20875407). May act in collecting-duct and biliary differentiation (By similarity). May participate in the regulation of the cholangiocytes proliferation and the CCN2 production in an CXCL8-dependent manner (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; The hepatocyte nuclear factor-1beta (HNF-1beta) C-terminal domain has a role in Pkhd1 (ARPKD) gene transcription and renal cystogenesis, [RefSeq, PubMed]", "predicted_glycosites": 51, "predicted_n_glycosites": 51, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 12, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 51, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005813 centrosome", "go_biological_process": "GO:0010824 regulation of centrosome duplication;GO:1904036 negative regulation of epithelial cell apoptotic process;GO:0008284 positive regulation of cell population proliferation;GO:0030155 regulation of cell adhesion;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "E9PZ36-1", "record_type": "protein", "filter_code": "0000000.1100111.001000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PZJ7-1", "uniprot_id": [ { "id": "E9PZJ7_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PZJ7", "type": "external" } ], "mass": 99223.0, "length": 861, "protein_name": "Vomeronasal 2, receptor 107", "gene_name": "Vmn2r107", "organism": "Mouse", "refseq_name": "vomeronasal 2, receptor 107 precursor", "refseq_ac": [ { "id": "NP_001098039", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098039", "type": "external" } ], "gene_names_uniprotkb": "Vmn2r107", "gene_names_refseq": "V2r6; Vmn107; Vmn2r107", "protein_names_uniprotkb": "Vomeronasal 2, receptor 107", "protein_names_refseq": "vomeronasal 2, receptor 107 precursor; vomeronasal 2, receptor, 6; vomeronasal organ family 2, receptor, 6; vomeronasal receptor Vmn2r107", "tax_id": 10090, "disease": "", "pathway": " (mmu:22312)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9PZJ7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q413-1", "uniprot_id": [ { "id": "E9Q413_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q413", "type": "external" } ], "mass": 34935.0, "length": 310, "protein_name": "Olfactory receptor", "gene_name": "Or8b53", "organism": "Mouse", "refseq_name": "olfactory receptor 920", "refseq_ac": [ { "id": "NP_666998", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666998", "type": "external" } ], "gene_names_uniprotkb": "Or8b53; Olfr920", "gene_names_refseq": "MOR165-6; Olfr920; Or8b53", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2PVTD-32458442-32459374; olfactory receptor 920; olfactory receptor MOR165-6", "tax_id": 10090, "disease": "", "pathway": " (mmu:258783)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25428506;30711253", "class_list": "", "function": "Odorant receptor., [UniProtKB, UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]; Olfr920 is expressed in primary cortical astrocytes and deorphanized to reveal isobutyric acid as a ligand., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, 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May be required for manchette assembly in elongating spermatids., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Loss-of-function mutations in IQCN cause male infertility in humans and mice owing to total fertilization failure., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0007286 spermatid development;GO:0007338 single fertilization;GO:0120316 sperm flagellum assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A1D5RMD1-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1W2P7H6-1", "uniprot_id": [ { "id": "A0A1W2P7H6_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A1W2P7H6", "type": "external" } ], "mass": 51439.0, "length": 457, "protein_name": "MINDY lysine 48 deubiquitinase 4B, pseudogene", "gene_name": "Mindy4b-ps", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mindy4b-ps", "gene_names_refseq": "", "protein_names_uniprotkb": "MINDY lysine 48 deubiquitinase 4B, pseudogene", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity;GO:1990380 K48-linked deubiquitinase activity", "go_cellular_component": "", "go_biological_process": "GO:0071108 protein K48-linked deubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A1W2P7H6-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "V9GX34-1", "uniprot_id": [ { "id": "V9GX34_MOUSE", "url": "https://www.uniprot.org/uniprot/V9GX34", "type": "external" } ], "mass": 392479.0, "length": 3611, "protein_name": "CUB and Sushi multiple domains 2", "gene_name": "Csmd2", "organism": "Mouse", "refseq_name": "CUB and sushi domain-containing protein 2", "refseq_ac": [ { "id": "NP_001268884", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001268884", "type": "external" } ], "gene_names_uniprotkb": "Csmd2", "gene_names_refseq": "Csmd2; Gm139", "protein_names_uniprotkb": "CUB and Sushi multiple domains 2", "protein_names_refseq": "CUB and sushi domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:329942)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;21750661;31068362", "class_list": "", "function": "Csmd2 plays a role in development and maintenance of dendrites and synapses. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 14, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 14, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 14, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 9577, "biomarker_type": "", "glycan_count": 12, "disease_count": 0, "glyco_site_count": 16, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0097107 postsynaptic density assembly;GO:0099562 maintenance of postsynaptic density structure", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "V9GX34-1", "record_type": "protein", "filter_code": "0000000.1000101.001000.000000000000100000.1000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1Y7VP58-1", "uniprot_id": [ { "id": "A0A1Y7VP58_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A1Y7VP58", "type": "external" } ], "mass": 10543.0, "length": 119, "protein_name": "Keratin associated protein 28-10", "gene_name": "Krtap28-10", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Krtap28-10", "gene_names_refseq": "", "protein_names_uniprotkb": "Keratin associated protein 28-10", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A1Y7VP58-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2A4E2-1", "uniprot_id": [ { "id": "A2A4E2_MOUSE", "url": "https://www.uniprot.org/uniprot/A2A4E2", "type": "external" } ], "mass": 47245.0, "length": 429, "protein_name": "Family with sequence similarity 90, member A1A", "gene_name": "Fam90a1a", "organism": "Mouse", "refseq_name": "protein FAM90A1", "refseq_ac": [ { "id": "NP_001075131", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075131", "type": "external" } ], "gene_names_uniprotkb": "Fam90a1a; C86695", "gene_names_refseq": "Fam90a1a", "protein_names_uniprotkb": "Family with sequence similarity 90, member A1A", "protein_names_refseq": "protein FAM90A1", "tax_id": 10090, "disease": "", "pathway": " (mmu:97476)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2A4E2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2ALV5-1", "uniprot_id": [ { "id": "SHOC1_MOUSE", "url": "https://www.uniprot.org/uniprot/A2ALV5", "type": "external" } ], "mass": 168065.0, "length": 1481, "protein_name": "Protein shortage in chiasmata 1 ortholog", "gene_name": "Shoc1", "organism": "Mouse", "refseq_name": "protein shortage in chiasmata 1 ortholog", "refseq_ac": [ { "id": "NP_001357772", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001357772", "type": "external" } ], "gene_names_uniprotkb": "Shoc1; Zip2", "gene_names_refseq": "Gm426; Mzip2; Shoc1", "protein_names_uniprotkb": "Protein shortage in chiasmata 1 ortholog; 3.6.-.-; MZip2; Protein ZIP2 homolog", "protein_names_refseq": "likely orthologue of H. sapiens chromosome 9 open reading frame 84; protein ZIP2 homolog; protein shortage in chiasmata 1 ortholog", "tax_id": 10090, "disease": "spermatogenic failure 75 (Disease Ontology:DOID:0070574)", "pathway": " (mmu:100155)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "29742103;30272023;30746471;35485979", "class_list": "", "function": "ATPase required during meiosis for the formation of crossover recombination intermediates (PubMed:29742103). Binds DNA: preferentially binds to single-stranded DNA and DNA branched structures (By similarity). Does not show nuclease activity in vitro, but shows ATPase activity, which is stimulated by the presence of single-stranded DNA (By similarity). Plays a key role in homologous recombination and crossing-over in meiotic prophase I in male and female germ cells (PubMed:30272023). Required for proper synaptonemal complex assembly and homologous chromosome pairing (PubMed:35485979). Required for recruitment of TEX11 and MSH4 to recombination intermediates (PubMed:30272023)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Analysis of SHOC1-deficient mice and the selective localization of SHOC1 to a subset of recombination sites show that SHOC1 acts at key mid-stage steps of the genetic crossovers (COs) ormation process. Publication Status: Online-Only, [RefSeq, PubMed]; Bi-allelic variants in SHOC1 cause non-obstructive azoospermia with meiosis arrest in humans and mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016887 ATP hydrolysis activity;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005694 chromosome", "go_biological_process": "GO:0000712 resolution of meiotic recombination intermediates;GO:0007130 synaptonemal complex assembly;GO:0007131 reciprocal meiotic recombination", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A2ALV5-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2BG94-1", "uniprot_id": [ { "id": "A2BG94_MOUSE", "url": "https://www.uniprot.org/uniprot/A2BG94", "type": "external" } ], "mass": 22010.0, "length": 208, "protein_name": "L antigen family member 3", "gene_name": "Ctag2l2", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC628518", "refseq_ac": [ { "id": "NP_001092776", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092776", "type": "external" } ], "gene_names_uniprotkb": "Ctag2l2; Gm6890", "gene_names_refseq": "Ctag2l2; EG628518; Gm6890", "protein_names_uniprotkb": "L antigen family member 3", "protein_names_refseq": "uncharacterized protein LOC628518", "tax_id": 10090, "disease": "", "pathway": " (mmu:628518)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. LAGE3 functions as a dimerization module for the complex., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000408 EKC/KEOPS complex", "go_biological_process": "GO:0008033 tRNA processing;GO:0070525 tRNA threonylcarbamoyladenosine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2BG94-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1AVB3-1", "uniprot_id": [ { "id": "B1AVB3_MOUSE", "url": "https://www.uniprot.org/uniprot/B1AVB3", "type": "external" } ], "mass": 106726.0, "length": 969, "protein_name": "Scm polycomb group protein like 2", "gene_name": "Scml2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Scml2", "gene_names_refseq": "", "protein_names_uniprotkb": "Scm polycomb group protein like 2", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:107815)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0031519 PcG protein complex;GO:0001741 XY body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006915 apoptotic process;GO:0045892 negative regulation of DNA-templated transcription;GO:0008104 intracellular protein localization;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B1AVB3-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1AYI8-1", "uniprot_id": [ { "id": "B1AYI8_MOUSE", "url": "https://www.uniprot.org/uniprot/B1AYI8", "type": "external" } ], "mass": 20597.0, "length": 182, "protein_name": "Predicted gene 13275", "gene_name": "Gm13275", "organism": "Mouse", "refseq_name": "interferon zeta-like precursor", "refseq_ac": [ { "id": "NP_001079002", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001079002", "type": "external" } ], "gene_names_uniprotkb": "Gm13275", "gene_names_refseq": "Gm13275; If1ha6", "protein_names_uniprotkb": "Predicted gene 13275", "protein_names_refseq": "interferon 1ha6; interferon zeta family Ifnz member; interferon zeta-like precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:545652)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005132 type I interferon receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0002312 B cell activation involved in immune response;GO:0051607 defense response to virus;GO:0060337 type I interferon-mediated signaling pathway;GO:0002250 adaptive immune response;GO:0043330 response to exogenous dsRNA", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B1AYI8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q069-1", "uniprot_id": [ { "id": "E9Q069_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q069", "type": "external" } ], "mass": 33177.0, "length": 297, "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r157", "organism": "Mouse", "refseq_name": "vomeronasal 1 receptor 157", "refseq_ac": [ { "id": "NP_001160226", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160226", "type": "external" } ], "gene_names_uniprotkb": "Vmn1r157", "gene_names_refseq": "100043559; EG667551; Gm4517; Gm8699; Vmn1r109; Vmn1r157", "protein_names_uniprotkb": "Vomeronasal type-1 receptor", "protein_names_refseq": "vomernasal 1 receptor Vmn1r109; vomernasal 1 receptor Vmn1r157; vomeronasal 1 receptor 109; vomeronasal 1 receptor 157", "tax_id": 10090, "disease": "", "pathway": " (mmu:667551)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005550 pheromone binding;GO:0016503 pheromone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E9Q069-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q236-1", "uniprot_id": [ { "id": "MRP4_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q236", "type": "external" } ], "mass": 148888.0, "length": 1325, "protein_name": "ATP-binding cassette sub-family C member 4", "gene_name": "Abcc4", "organism": "Mouse", "refseq_name": "ATP-binding cassette sub-family C member 4 isoform 1", "refseq_ac": [ { "id": "NP_001028508", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028508", "type": "external" } ], "gene_names_uniprotkb": "Abcc4; Mrp4", "gene_names_refseq": "ABCC4-N1; Abcc4; D630049P08Rik; MOATB; MRP4", "protein_names_uniprotkb": "ATP-binding cassette sub-family C member 4; 7.6.2.-; 7.6.2.2; 7.6.2.3; Multidrug resistance-associated protein 4", "protein_names_refseq": "ATP-binding cassette sub-family C member 4 isoform 1; ATP-binding cassette, sub-family C (CFTR/MRP), member 4; multidrug resistance-associated protein 4", "tax_id": 10090, "disease": "cholestasis (Disease Ontology:DOID:13580); extrahepatic cholestasis (Disease Ontology:DOID:13619); cystic fibrosis (Disease Ontology:DOID:1485); primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (mmu:239273); (R-MMU-114608); (R-MMU-382556); (R-MMU-9748787); (R-MMU-9753281)", "pathway_count": 5, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;12883481;15004017;15314169;17210706;17242355;19144319;21750661;27613143;33851387;36943419;37988981", "class_list": "", "function": "ABCC4 impacts megakaryopoiesis and protects megakaryocytes against 6-mercaptopurine induced cytotoxicity., [RefSeq, PubMed]; ABCC4 is a PGE2 efflux transporter in the ovarian follicle: A mediator of ovulation and a potential non-hormonal contraceptive target., [RefSeq, PubMed]; ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells (By similarity). Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (By similarity). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (By similarity). Mediates the cotransport of bile acids with reduced glutathione (GSH) (By similarity). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotic molecules (By similarity). Confers resistance to anticancer agents such as methotrexate (By similarity)., [UniProtKB, UniProtKB]; Abcc4 can mediate the efflux of reduced glutathione from hepatocytes into blood by cotransport with monoanionic bile salts., [RefSeq, PubMed]; And Sult2a1 participate in an integrated pathway mediating elimination of sulfated steroid and bile acid metabolites from the liver, [RefSeq, PubMed]; Role of Membrane Lipid Rafts in MRP4 (ABCC4) Dependent Regulation of the cAMP Pathway in Blood Platelets., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A1C9IC75;B7ZWC5;Q3TZN9", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" } ], "go_molecular_function": "GO:0042910 xenobiotic transmembrane transporter activity;GO:0005524 ATP binding;GO:0022857 transmembrane transporter activity;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0015721 bile acid and bile salt transport;GO:0048661 positive regulation of smooth muscle cell proliferation;GO:0060271 cilium assembly;GO:0006855 xenobiotic transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "E9Q236-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q2Y0-1", "uniprot_id": [ { "id": "E9Q2Y0_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q2Y0", "type": "external" } ], "mass": 16217.0, "length": 151, "protein_name": "EP300 interacting inhibitor of differentiation 2B", "gene_name": "Eid2b", "organism": "Mouse", "refseq_name": "EP300-interacting inhibitor of differentiation 2B", "refseq_ac": [ { "id": "NP_001170898", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001170898", "type": "external" } ], "gene_names_uniprotkb": "Eid2b", "gene_names_refseq": "3010005C08Rik; Eid2b", "protein_names_uniprotkb": "EP300 interacting inhibitor of differentiation 2B", "protein_names_refseq": "EP300-interacting inhibitor of differentiation 2B", "tax_id": 10090, "disease": "", "pathway": " (mmu:434156)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0045892 negative regulation of DNA-templated transcription;GO:0045662 negative regulation of myoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9Q2Y0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q4T4-1", "uniprot_id": [ { "id": "E9Q4T4_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q4T4", "type": "external" } ], "mass": 24213.0, "length": 218, "protein_name": "Coiled-coil domain containing 71 like", "gene_name": "Ccdc71l", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 71L", "refseq_ac": [ { "id": "NP_001156375", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156375", "type": "external" } ], "gene_names_uniprotkb": "Ccdc71l; 2010109K11Rik", "gene_names_refseq": "2010109K11Rik; Ccdc71l", "protein_names_uniprotkb": "Coiled-coil domain containing 71 like", "protein_names_refseq": "coiled-coil domain-containing protein 71L", "tax_id": 10090, "disease": "", "pathway": " (mmu:72123)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, 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complex", "go_biological_process": "GO:0045040 protein insertion into mitochondrial outer membrane;GO:0015031 protein transport;GO:0070096 mitochondrial outer membrane translocase complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3YTP3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PXF8-1", "uniprot_id": [ { "id": "MTMRD_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PXF8", "type": "external" } ], "mass": 210458.0, "length": 1872, "protein_name": "Myotubularin-related protein 13", "gene_name": "Sbf2", "organism": "Mouse", "refseq_name": "myotubularin-related protein 13 isoform 1", "refseq_ac": [ { "id": "NP_796298", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796298", "type": "external" } ], "gene_names_uniprotkb": "Sbf2", "gene_names_refseq": "4833411B01Rik; B430219L04Rik; Mtmr13; Sbf2; mMTMH1", "protein_names_uniprotkb": "Myotubularin-related protein 13; Inactive phosphatidylinositol 3-phosphatase 13; SET-binding factor 2", "protein_names_refseq": "inactive phosphatidylinositol 3-phosphatase 13; myotubularin related protein 13; myotubularin-related protein 13 isoform 1; myotubularin-related protein 5", "tax_id": 10090, "disease": "Charcot-Marie-Tooth disease type 4B2 (Disease Ontology:DOID:0110190); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:319934); (R-MMU-8876198)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;16399794;16750429;17855448;18349142;19892989;19912440;21750661;21952136;22648168;23297362;27669760;34428180;34718573", "class_list": "", "function": "Data indicate that Mtmr2 and Mtmr13/Sbf2 play critical roles in the sorting and modulation of cellular signalling which are likely to be disturbed in Charcot-Marie-Tooth disease type 4B, [RefSeq, PubMed]; Distinct roles for the Charcot-Marie-Tooth disease-causing endosomal regulators Mtmr5 and Mtmr13 in axon radial sorting and Schwann cell myelination., [RefSeq, PubMed]; Guanine nucleotide exchange factor (GEF) which activates RAB21 and possibly RAB28 (By similarity). Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity). In response to starvation-induced autophagy, activates RAB21 which in turn binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (By similarity). Acts as an adapter for the phosphatase MTMR2 (PubMed:16399794). Increases MTMR2 catalytic activity towards phosphatidylinositol 3,5-bisphosphate and to a lesser extent towards phosphatidylinositol 3-phosphate (PubMed:16399794)., [UniProtKB, PubMed, UniProtKB]; Mtmr13-deficient mice develop a peripheral neuropathy characterized by reduced nerve conduction velocity and myelin outfoldings and infoldings., [RefSeq, PubMed]; Mtmr2 and Mtmr13 depend upon each other to achieve wild-type levels of protein expression. Mtmr2 stabilizes Mtmr13 on membranes, indicating that the Mtmr13 pseudophosphatase is regulated by its catalytically active binding partner., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "E9Q305;Q8BJ67;Q8BJD2;Q8BJP4;Q91VH0", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0035091 phosphatidylinositol binding;GO:0019902 phosphatase binding;GO:0019208 phosphatase regulator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0030424 axon;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "E9PXF8-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PWZ3-1", "uniprot_id": [ { "id": "RL3L_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PWZ3", "type": "external" } ], "mass": 46512.0, "length": 407, "protein_name": "Large ribosomal subunit protein uL3-like", "gene_name": "Rpl3l", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein uL3-like isoform 1", "refseq_ac": [ { "id": "NP_001157417", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157417", "type": "external" } ], "gene_names_uniprotkb": "Rpl3l", "gene_names_refseq": "1110057H16Rik; Rpl3l", "protein_names_uniprotkb": "Large ribosomal subunit protein uL3-like; 60S ribosomal protein L3-like", "protein_names_refseq": "60S ribosomal protein L3-like; large ribosomal subunit protein uL3-like isoform 1; large ribosomal subunit protein uL3-like; ribosomal protein L3 pseudogene", "tax_id": 10090, "disease": "dilated cardiomyopathy 2D (Disease Ontology:DOID:0081160)", "pathway": " (mmu:66211); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72689); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954709); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 11, "publication_count": 9, "publication_id_list": "21750661;26684695;31599954;34081545;36517592;36882085;37080962;37507081;38254943", "class_list": "", "function": "Dynamic interplay between RPL3- and RPL3L-containing ribosomes modulates mitochondrial activity in the mammalian heart., [RefSeq, PubMed]; Exploring the Regulation and Function of Rpl3l in the Development of Early-Onset Dilated Cardiomyopathy and Congestive Heart Failure Using Systems Genetics Approach. Publication Status: Online-Only, [RefSeq, PubMed]; Heart- and skeletal muscle-specific component of the ribosome, which regulates muscle function (PubMed:26684695, PubMed:34081545, PubMed:36517592). Component of the large ribosomal subunit in striated muscle cells: replaces the RPL3 paralog in the ribosome in these cells (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Inhibits myotube growth and muscle function (PubMed:26684695, PubMed:34081545)., [UniProtKB, PubMed, PubMed, PubMed]; Knockdown of Muscle-Specific Ribosomal Protein L3-Like Enhances Muscle Function in Healthy and Dystrophic Mice., [RefSeq, PubMed]; RPL3L-containing ribosomes determine translation elongation dynamics required for cardiac function. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5U470;Q9CQ09", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005737 cytoplasm;GO:0022625 cytosolic large ribosomal subunit;GO:0005840 ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0016202 regulation of striated muscle tissue development;GO:0006412 translation;GO:0006941 striated muscle contraction;GO:0010832 negative regulation of myotube differentiation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "E9PWZ3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q5A6-1", "uniprot_id": [ { "id": "E9Q5A6_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q5A6", "type": "external" } ], "mass": 57163.0, "length": 505, "protein_name": "Nuclear receptor subfamily 1, group H, member 5", "gene_name": "Nr1h5", "organism": "Mouse", "refseq_name": "nuclear receptor subfamily 1, group H, member 5 isoform 1", "refseq_ac": [ { "id": "NP_941060", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_941060", "type": "external" } ], "gene_names_uniprotkb": "Nr1h5", "gene_names_refseq": "Fxrb; Nr1h5", "protein_names_uniprotkb": "Nuclear receptor subfamily 1, group H, member 5", "protein_names_refseq": "nuclear receptor subfamily 1, group H, member 5 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:381463)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0043565 sequence-specific DNA binding;GO:0004879 nuclear receptor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006629 lipid metabolic process;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E9Q5A6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PV98-1", "uniprot_id": [ { "id": "E9PV98_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PV98", "type": "external" } ], "mass": 57762.0, "length": 497, "protein_name": "Tripartite motif-containing 5", "gene_name": "Trim5", "organism": "Mouse", "refseq_name": "tripartite motif-containing 5", "refseq_ac": [ { "id": "NP_001297531", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297531", "type": "external" } ], "gene_names_uniprotkb": "Trim5", "gene_names_refseq": "EG667823; Gm8833; Trim5", "protein_names_uniprotkb": "Tripartite motif-containing 5", "protein_names_refseq": "tripartite motif-containing 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:667823)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "20484733;21750661;30059200", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0019901 protein kinase binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000932 P-body", "go_biological_process": "GO:0046596 regulation of viral entry into host cell;GO:0044790 suppression of viral release by host;GO:0043410 positive regulation of MAPK cascade;GO:0045087 innate immune response;GO:0032880 regulation of protein localization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "E9PV98-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PW83-1", "uniprot_id": [ { "id": "E9PW83_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PW83", "type": "external" } ], "mass": 132973.0, "length": 1143, "protein_name": "Family with sequence similarity 184, member A", "gene_name": "Fam184a", "organism": "Mouse", "refseq_name": "protein FAM184A", "refseq_ac": [ { "id": "NP_001074897", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074897", "type": "external" } ], "gene_names_uniprotkb": "Fam184a", "gene_names_refseq": "3110012E06Rik; 4930438C08Rik; 4930589M24Rik; Fam184a", "protein_names_uniprotkb": "Family with sequence similarity 184, member A", "protein_names_refseq": "protein FAM184A", "tax_id": 10090, "disease": "", "pathway": " (mmu:75906)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000932 P-body;GO:0034451 centriolar satellite;GO:0036064 ciliary basal body", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9PW83-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JGF9-1", "uniprot_id": [ { "id": "A0A0G2JGF9_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A0G2JGF9", "type": "external" } ], "mass": 12402.0, "length": 115, "protein_name": "Immunoglobulin kappa variable 12-98", "gene_name": "Igkv12-98", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Igkv12-98", "gene_names_refseq": "", "protein_names_uniprotkb": "Immunoglobulin kappa variable 12-98", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2JGF9-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "K7N727-1", "uniprot_id": [ { "id": "K7N727_MOUSE", "url": "https://www.uniprot.org/uniprot/K7N727", "type": "external" } ], "mass": 35852.0, "length": 320, "protein_name": "Olfactory receptor", "gene_name": "Or10u4", "organism": "Mouse", "refseq_name": "olfactory receptor family 10 subfamily U member 4", "refseq_ac": [ { "id": "NP_001159416", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159416", "type": "external" } ], "gene_names_uniprotkb": "Or10u4; 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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Also involved in the conversion of iodide (I(-)) into hypoiodite (IO(-)) in the presence of H2O2 (By similarity). Responsible for the inactivation of a wide range of micro-organisms and hence, important component of defense mechanism (By similarity). May be implicated in airway host defense against infection (By similarity). May contribute to maintaining an appropriate H2O2 cellular level, therefore protecting cells from H2O2-caused injuries and inflammation (PubMed:34127712)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Methylation of the Lpo intragenic CpG island was not directly induced by inflammation, because dextran sulfate sodium-induced colitis did not increase DNA methylation in B6 DKO colon. 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Gm13125; Pramef20; Pramel15", "protein_names_uniprotkb": "PRAME like 15", "protein_names_refseq": "PRAME family member 20; novel preferentially expressed antigen in melanoma (Prame) protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:627009)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;39181896", "class_list": "", "function": "Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation. 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"reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000795 synaptonemal complex", "go_biological_process": "GO:0097061 dendritic spine organization;GO:0007286 spermatid development;GO:0042220 response to cocaine;GO:0051321 meiotic cell cycle;GO:0014046 dopamine secretion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A2BI40-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "J3QK55-1", "uniprot_id": [ { "id": "J3QK55_MOUSE", "url": "https://www.uniprot.org/uniprot/J3QK55", "type": "external" } ], "mass": 50985.0, "length": 433, "protein_name": "RIKEN cDNA 2010315B03 gene", "gene_name": "2010315B03Rik", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC630836 isoform 3", "refseq_ac": [ { "id": "NP_001230048", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001230048", "type": "external" } ], "gene_names_uniprotkb": "2010315B03Rik", "gene_names_refseq": "2010315B03Rik", "protein_names_uniprotkb": "RIKEN cDNA 2010315B03 gene", "protein_names_refseq": "uncharacterized protein LOC630836 isoform 3", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "J3QK55-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E0CZ22-1", "uniprot_id": [ { "id": "MROH1_MOUSE", "url": "https://www.uniprot.org/uniprot/E0CZ22", "type": "external" } ], "mass": 181795.0, "length": 1640, "protein_name": "Maestro heat-like repeat-containing protein family member 1", "gene_name": "Mroh1", "organism": "Mouse", "refseq_name": "maestro heat-like repeat-containing protein family member 1 isoform 2", "refseq_ac": [ { "id": "NP_001155961", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155961", "type": "external" } ], "gene_names_uniprotkb": "Mroh1; Heatr7a; Kiaa1833", "gene_names_refseq": "D330001F17Rik; Heatr7a; Mroh1", "protein_names_uniprotkb": "Maestro heat-like repeat-containing protein family member 1", "protein_names_refseq": "HEAT repeat containing 7A; maestro heat-like repeat-containing protein family member 1 isoform 2; maestro heat-like repeat-containing protein family member 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:223658)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "Lysosome fission factor. Recruited to lysosomes by RAB7 (RAB7A or RAB7B) at scission sites and homooligomerizes to mediate the constriction and scission of lysosomal tubules. May sever membranes by inserting amphipathic helices into one bilayer leaflet. Lysosome fission is required to maintain their steady-state number, shape, size, composition and function, and to accomplish regeneration., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3Z624;E0CYC5;Q80T84", "ec_number_list": [], "go_molecular_function": "GO:0140912 membrane destabilizing activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0170064 lysosome fission", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E0CZ22-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SPH3-1", "uniprot_id": [ { "id": "Q5SPH3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5SPH3", "type": "external" } ], "mass": 59844.0, "length": 536, "protein_name": "Amine oxidase", "gene_name": "4930438A08Rik", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC73988 precursor", "refseq_ac": [ { "id": "NP_001361634", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001361634", "type": "external" } ], "gene_names_uniprotkb": "4930438A08Rik", "gene_names_refseq": "4930438A08Rik", "protein_names_uniprotkb": "Amine oxidase; 1.4.3.-", "protein_names_refseq": "uncharacterized protein LOC73988 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:73988)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001716 L-amino-acid oxidase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0009063 amino acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5SPH3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "V9GX91-1", "uniprot_id": [ { "id": "NAV2_MOUSE", "url": "https://www.uniprot.org/uniprot/V9GX91", "type": "external" } ], "mass": 261662.0, "length": 2432, "protein_name": "Neuron navigator 2", "gene_name": "Nav2", "organism": "Mouse", "refseq_name": "neuron navigator 2 isoform 1", "refseq_ac": [ { "id": "NP_780481", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780481", "type": "external" } ], "gene_names_uniprotkb": "Nav2", "gene_names_refseq": "5330421F07Rik; HELAD1; Nav2; POMFIL2; RAINB1; RAINB2; Unc53H2; mKIAA3015", "protein_names_uniprotkb": "Neuron navigator 2; 3.6.4.12", "protein_names_refseq": "neuron navigator 2 isoform 1; retinoic acid inducible in neuroblastoma", "tax_id": 10090, "disease": "cerebellar hypoplasia (Disease Ontology:DOID:0070338)", "pathway": " (mmu:78286)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15158073;17242355;19144319;20184720;21419114;21750661;25605945;32081718;35218524;38152138", "class_list": "", "function": "Identification of novel genes including NAV2 associated with isolated tall stature. Publication Status: Online-Only, [RefSeq, PubMed]; Possesses 3' to 5' helicase activity and exonuclease activity (By similarity). Involved in cytoskeleton organization (By similarity). Required for neurite outgrowth in response to stimulation by all-trans retinoic acid (atRA) (By similarity). Involved in neuronal development, specifically in the development of different sensory organs (PubMed:35218524). Important for brain and cerebellar development (PubMed:21419114, PubMed:32081718, PubMed:35218524). Involved in the differentiation, migration and axonal extension of granule cells in the developing cerebellum (PubMed:21419114). Involved in the development of the glossopharyngeal cranial nerve IX and the vagus cranial nerve X, possibly by influencing neuronal cell elongation or survival; influencing the efficiency of the baroreceptor reflex response to changes in blood pressure (PubMed:20184720)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Possesses 3' to 5' helicase activity and exonuclease activity. Involved in cytoskeleton organization. Required for neurite outgrowth in response to stimulation by all-trans retinoic acid (atRA). Involved in neuronal development, specifically in the development of different sensory organs. Important for brain and cerebellar development. Involved in the differentiation, migration and axonal extension of granule cells in the developing cerebellum. Involved in the development of the glossopharyngeal cranial nerve IX and the vagus cranial nerve X, possibly by influencing neuronal cell elongation or survival; influencing the efficiency of the baroreceptor reflex response to changes in blood pressure., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0043138 3'-5' DNA helicase activity;GO:0005524 ATP binding;GO:0008201 heparin binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005856 cytoskeleton;GO:0030424 axon;GO:0031012 extracellular matrix;GO:0043204 perikaryon", "go_biological_process": "GO:0003025 regulation of systemic arterial blood pressure by baroreceptor feedback;GO:0021563 glossopharyngeal nerve development;GO:0021564 vagus nerve development;GO:0007399 nervous system development;GO:0007626 locomotory behavior", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "V9GX91-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A075B651-1", "uniprot_id": [ { "id": "A0A075B651_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A075B651", "type": "external" } ], "mass": 12295.0, "length": 110, "protein_name": "T cell receptor alpha variable 4-4-DV10", "gene_name": "Trav4-4-dv10", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Trav4-4-dv10", "gene_names_refseq": "", "protein_names_uniprotkb": "T cell receptor alpha variable 4-4-DV10", "protein_names_refseq": "", "tax_id": 10090, 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"go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A0G2JFA3-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A140LI88-1", "uniprot_id": [ { "id": "ANR31_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A140LI88", "type": "external" } ], "mass": 206173.0, "length": 1857, "protein_name": "Ankyrin repeat domain-containing protein 31", "gene_name": "Ankrd31", "organism": "Mouse", "refseq_name": "ankyrin repeat domain-containing protein 31", "refseq_ac": [ { "id": "NP_001357857", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001357857", "type": "external" } ], "gene_names_uniprotkb": "Ankrd31", "gene_names_refseq": "Ankrd31", "protein_names_uniprotkb": "Ankyrin repeat domain-containing protein 31", "protein_names_refseq": "ankyrin repeat domain-containing protein 31", "tax_id": 10090, "disease": "", "pathway": " (mmu:625662)", 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In vivo, ANKRD31 stabilizes REC114 association with the PAR and elsewhere. Our findings inform a model in which ANKRD31 is a scaffold anchoring REC114 and other factors to specific genomic locations, thereby regulating DSB formation., [RefSeq, PubMed]; Essential roles of the ANKRD31-REC114 interaction in meiotic recombination and mouse spermatogenesis., [RefSeq, PubMed]; Required for DNA double-strand breaks (DSBs) formation during meiotic recombination (PubMed:31000436, PubMed:31003867). Regulates the spatial and temporal patterns of pre-DSB recombinosome assembly and recombination activity by acting as a scaffold that anchors REC114 and other factors to specific genomic locations, thereby regulating DSB formation (PubMed:31000436, PubMed:31003867). Plays a key role in recombination in the pseudoautosomal regions of sex chromosomes (PubMed:31000436)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A140LIB3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0007129 homologous chromosome pairing at meiosis;GO:0010780 meiotic DNA double-strand break formation involved in reciprocal meiotic recombination;GO:1903343 positive regulation of meiotic DNA double-strand break formation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A140LI88-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A140LIJ0-1", "uniprot_id": [ { "id": "DCST2_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A140LIJ0", "type": "external" } ], "mass": 78574.0, "length": 701, "protein_name": "DC-STAMP domain-containing protein 2", "gene_name": "Dcst2", "organism": "Mouse", "refseq_name": "DC-STAMP domain-containing protein 2", "refseq_ac": [ { "id": "NP_001357782", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001357782", "type": "external" } ], "gene_names_uniprotkb": "Dcst2", "gene_names_refseq": "Dcst2; Gm760", "protein_names_uniprotkb": "DC-STAMP domain-containing protein 2", "protein_names_refseq": "DC-STAMP domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:329702)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "33871360;35393517", "class_list": "", "function": "Essential sperm cell-surface protein required for sperm-egg fusion and fertilization., [UniProtKB, PubMed, PubMed]; Sperm membrane proteins DCST1 and DCST2 are required for sperm-egg interaction in mice and fish. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0002080 acrosomal membrane", "go_biological_process": "GO:0035036 sperm-egg recognition;GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A140LIJ0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5RLC8-1", "uniprot_id": [ { "id": "A0A1D5RLC8_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A1D5RLC8", "type": "external" } ], "mass": 27647.0, "length": 261, "protein_name": "MARCO like", "gene_name": "Marcol", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Marcol; Gm37797", "gene_names_refseq": "", "protein_names_uniprotkb": "MARCO like", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A1D5RLC8-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "L7N1X4-1", "uniprot_id": [ { "id": "L7N1X4_MOUSE", "url": "https://www.uniprot.org/uniprot/L7N1X4", "type": "external" } ], "mass": 74991.0, "length": 647, "protein_name": "Zinc finger protein 457", "gene_name": "Zfp457", "organism": "Mouse", "refseq_name": "zinc finger protein 457", "refseq_ac": [ { "id": "NP_001003666", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003666", "type": "external" } ], "gene_names_uniprotkb": "Zfp457", "gene_names_refseq": "Rslcan-6; 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Nup62cl", "protein_names_uniprotkb": "Nucleoporin 62 C-terminal like", "protein_names_refseq": "novel Nsp1-like C-terminal region containing protein; nucleoporin-62 C-terminal-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:279706)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0044613 nuclear pore central transport channel;GO:0005643 nuclear pore", "go_biological_process": "GO:0006405 RNA export from nucleus;GO:0006606 protein import into nucleus;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2AG10-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6X8I0-1", "uniprot_id": [ { "id": "A6X8I0_MOUSE", "url": "https://www.uniprot.org/uniprot/A6X8I0", "type": "external" } ], "mass": 24694.0, "length": 212, "protein_name": "Predicted gene 1993", "gene_name": "Gm1993", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC100038977", "refseq_ac": [ { "id": "NP_001096147", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096147", "type": "external" } ], "gene_names_uniprotkb": "Gm1993", "gene_names_refseq": "100038977; 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Recruited to young transposons, which are specifically marked with histone H3 trimethylated at both 'Lys-4' and 'Lys-9' (H3K4me3K9me3), via its association with SPIN1 chromatin reader, and associates with the de novo DNA methylation machinery and repressive chromatin remodeling complexes (PubMed:32674113, PubMed:39294378). Following this, PIWIL4 engages with nascent transposable element transcript to direct piRNA-directed DNA methylation (PubMed:39294378). Not required for piRNA biosynthesis (PubMed:32674113)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005694 chromosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0141006 transposable element silencing by piRNA-mediated heterochromatin formation;GO:0141176 gene silencing by piRNA-directed DNA methylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "B1ASB6-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3YX18-1", "uniprot_id": [ { "id": "D3YX18_MOUSE", "url": "https://www.uniprot.org/uniprot/D3YX18", "type": "external" } ], "mass": 5668.0, "length": 52, "protein_name": "Keratin associated protein 20-22", "gene_name": "Krtap20-22", "organism": "Mouse", "refseq_name": "keratin-associated protein 20-2-like", "refseq_ac": [ { "id": "XP_006523187", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006523187", "type": "external" } ], "gene_names_uniprotkb": "Krtap20-22; 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Component of the vault particle, which is a massive ribonucleoprotein complex that may play a role in cargo transport and signal transduction (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, 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CENF; Cenpf; Lek1; PRO1779; mitosin", "protein_names_uniprotkb": "Centromere protein F", "protein_names_refseq": "centromere autoantigen F; centromere protein F; leucine, glutamic acid, lysine family 1 protein", "tax_id": 10090, "disease": "Stromme syndrome (Disease Ontology:DOID:0110595); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (mmu:108000); (R-MMU-141430); (R-MMU-141444); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-5663220); (R-MMU-68877); (R-MMU-9648025)", "pathway_count": 8, "publication_count": 5, "publication_id_list": "21750661;25428506;34676150;36513638;39927985", "class_list": "", "function": "Apoptosis-induced translocation of centromere protein F in its corresponding autoantibody production in hepatocellular carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; CENP-F-dependent DRP1 function regulates APC/C activity during oocyte meiosis I. 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surface receptor signaling pathway;GO:0019221 cytokine-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9Q1Z6-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q5I3-1", "uniprot_id": [ { "id": "E9Q5I3_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q5I3", "type": "external" } ], "mass": 515441.0, "length": 4800, "protein_name": "Mucin-2", "gene_name": "Muc5b", "organism": "Mouse", "refseq_name": "mucin-5B precursor", "refseq_ac": [ { "id": "NP_083077", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083077", "type": "external" } ], "gene_names_uniprotkb": "Muc5b", "gene_names_refseq": "2300002I04Rik; A130042M24; MUC5; MUC9; Muc5b; mucin 5b", "protein_names_uniprotkb": "Mucin-2", "protein_names_refseq": "mucin-5B precursor", "tax_id": 10090, "disease": "sinusitis (Disease Ontology:DOID:0050127); interstitial lung disease 2 (Disease Ontology:DOID:0060971); otitis media (Disease Ontology:DOID:10754); urinary bladder cancer (Disease Ontology:DOID:11054); cystic fibrosis (Disease Ontology:DOID:1485); asthma (Disease Ontology:DOID:2841); bronchiolitis (Disease Ontology:DOID:2942); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); cholangiocarcinoma (Disease Ontology:DOID:4947); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (mmu:74180); (R-MMU-913709); (R-MMU-977068)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;11964160;14718370;21750661;25428506;35881171;36108173;36111525", "class_list": "", "function": "C-mannosylation is likely required for proper folding of the Cys subdomains and/or for some aspect of ER export during mucin biosynthesis, [RefSeq, PubMed]; De novo NUF2 variant in a novel inherited bone marrow failure syndrome including microcephaly and renal hypoplasia., [RefSeq, PubMed]; Epithelial Endoplasmic Reticulum Stress Enhances the Risk of Muc5b-associated Lung Fibrosis., [RefSeq, PubMed]; Muc5b plays a role in the development of inflammation and fibrosis in hypersensitivity pneumonitis induced by Saccharopolyspora rectivirgula., [RefSeq, PubMed]; The isolation and characterization of the mouse Muc5b mucin gene (mMuc5b), determined its complete cDNA sequence, its genomic organization, and chromosomal localization and expression., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 7, "reported_o_glycosites_with_glycan": 0, 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Publication Status: Online-Only, [RefSeq, PubMed]; Essential for sperm flagellum biogenesis and male fertility., [UniProtKB, PubMed, PubMed]; Homozygous CCDC146 mutation causes oligoasthenoteratozoospermia in humans and mice., [RefSeq, PubMed]; Lack of CCDC146, a ubiquitous centriole and microtubule-associated protein, leads to non-syndromic male infertility in human and mouse. 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"synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2A592-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2A752-1", "uniprot_id": [ { "id": "A2A752_MOUSE", "url": "https://www.uniprot.org/uniprot/A2A752", "type": "external" } ], "mass": 45735.0, "length": 406, "protein_name": "AADACL4 family member 2", "gene_name": "Aadacl4fm2", "organism": "Mouse", "refseq_name": "Arylacetamide deacetylase-like 4-like", "refseq_ac": [ { "id": "NP_001079011", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001079011", "type": "external" } ], "gene_names_uniprotkb": "Aadacl4fm2; Gm13124", "gene_names_refseq": "Aadacl4fm2; Gm13124", "protein_names_uniprotkb": "AADACL4 family member 2", "protein_names_refseq": "Arylacetamide deacetylase-like 4-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:627085)", "pathway_count": 1, "publication_count": 1, "publication_id_list": 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10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016787 hydrolase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2A752-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z7Q2-1", "uniprot_id": [ { "id": "SIM20_MOUSE", "url": "https://www.uniprot.org/uniprot/D3Z7Q2", "type": "external" } ], "mass": 7818.0, "length": 69, "protein_name": "Small integral membrane protein 20", "gene_name": "Smim20", "organism": "Mouse", "refseq_name": "small integral membrane protein 20", "refseq_ac": [ { "id": "NP_001138905", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138905", "type": "external" } ], "gene_names_uniprotkb": "Smim20", "gene_names_refseq": "1110067B18Rik; 1810013D10Rik; MITRAC7; Smim20", "protein_names_uniprotkb": "Small integral membrane protein 20; MITRAC7; Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 7 kDa", "protein_names_refseq": "mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 7 kDa; small integral membrane protein 20", "tax_id": 10090, "disease": "", "pathway": " (mmu:66278); (R-MMU-9864848)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "21750661;23912037;25428506;25687846;26415767;26505917;27268078;30251651;30524225;30933929;31422055;34428180", "class_list": "", "function": "Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly (By similarity). Promotes the progression of complex assembly after the association of MT-CO1/COX1 with COX4I1 and COX6C (By similarity). Chaperone-like assembly factor required to stabilize newly synthesized MT-CO1/COX1 and to prevent its premature turnover (By similarity)., [UniProtKB, UniProtKB]; Peptide involved in a broad spectrum of regulatory functions (PubMed:25687846, PubMed:26505917, PubMed:27268078). Is a ligand for GPR173 (By similarity). As part of the reproductive cycle, it regulates gonadotropin-releasing hormone (GnRH) signaling in the hypothalamus and pituitary gland which augments the release of luteinizing hormone (PubMed:27268078). More specifically, it regulates the expression of transcription factors CEBPB and POU2F1/OCT1 through the cAMP-PKA signaling pathway, which subsequently regulate the expression of GNRHR and KISS1 (PubMed:27268078). Plays a protective role in memory retention through activation of GNRHR (PubMed:26505917). Regulates the secretion of AVP by hypothalamic neurons (By similarity). Plays a role in the transduction of the itch sensation (PubMed:26415767). Induces anxiolytic effects, reducing behavior associated with anxiety (PubMed:25687846). Regulates food intake as well as satiation and satiety by increasing Nucb2 expression in neurons (By similarity). In the ovary, it regulates follicular growth by stimulating granulosa cell proliferation by increasing the expression of GPR173, CREB1, CYP19A1, KITLG, FSHR, and LHCGR (PubMed:30933929). It also increases the production of estradiol (E2) (PubMed:30933929). In the heart, it regulates contractility and relaxation by activating the AKT1-NOS3 and MAPK1-MAPK3 signaling pathways (By similarity). It also plays a cardioprotective role during ischemia, where it activates the SAFE and RISK pathways (By similarity). Stimulates the proliferation and differentiation of preadipocytes (PubMed:30251651). In pancreatic islet cells, it induces proliferation of islet cells as well as the production of INS through activation of the MAPK1-MAPK3 signaling pathways (PubMed:31422055)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005743 mitochondrial inner membrane;GO:0005739 mitochondrion;GO:0016020 membrane", "go_biological_process": "GO:0033617 mitochondrial respiratory chain complex IV assembly", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "D3Z7Q2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E0CXI6-1", "uniprot_id": [ { "id": "E0CXI6_MOUSE", "url": "https://www.uniprot.org/uniprot/E0CXI6", "type": "external" } ], "mass": 40919.0, "length": 357, "protein_name": "Speckle-type BTB/POZ protein family member 3", "gene_name": "Spopfm3", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Spopfm3; 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EG384557; Psg24; cea12", "protein_names_uniprotkb": "CEA cell adhesion molecule 3", "protein_names_refseq": "carcinoembryonic antigen-related cell adhesion molecule 3 precursor; carcinoembryonic antigen-related cell adhesion molecule 3; pregnancy-specific glycoprotein 24", "tax_id": 10090, "disease": "", "pathway": " (mmu:384557)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006955 immune response;GO:0042110 T cell activation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9Q6J4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q9A6-1", "uniprot_id": [ { "id": "E9Q9A6_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q9A6", "type": "external" } ], "mass": 34392.0, "length": 308, "protein_name": "Interleukin 20 receptor beta", "gene_name": "Il20rb", "organism": "Mouse", "refseq_name": "interleukin-20 receptor subunit beta precursor", "refseq_ac": [ { "id": "NP_001028715", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028715", "type": "external" } ], "gene_names_uniprotkb": "Il20rb", "gene_names_refseq": "Fndc6; Gm186; Il20R2; Il20rb", "protein_names_uniprotkb": "Interleukin 20 receptor beta", "protein_names_refseq": "fibronectin type III domain containing 6; interleukin-20 receptor subunit beta precursor; interleukin-20 receptor subunit beta", "tax_id": 10090, "disease": "", "pathway": " (mmu:213208); (R-MMU-5684996); (R-MMU-8854691)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "17069926;21750661;38056582", "class_list": "", "function": "IL-20R2 receptor subunit is up-regulated by LPS in the liver of normal mice., [RefSeq, PubMed]; Spinal interleukin-24 contributes to neuropathic pain after peripheral nerve injury through interleukin-20 receptor2 in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004896 cytokine receptor activity;GO:0042015 interleukin-20 binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0030876 interleukin-20 receptor complex", "go_biological_process": "GO:0032703 negative regulation of interleukin-2 production;GO:0002437 inflammatory response to antigenic stimulus;GO:0032689 negative regulation of type II interferon production;GO:0042130 negative regulation of T cell proliferation;GO:0048873 homeostasis of number of cells within a tissue", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "E9Q9A6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F8VPJ8-1", "uniprot_id": [ { "id": "F8VPJ8_MOUSE", "url": "https://www.uniprot.org/uniprot/F8VPJ8", "type": "external" } ], "mass": 36062.0, "length": 320, "protein_name": "Olfactory receptor", "gene_name": "Or52z1", "organism": "Mouse", "refseq_name": "olfactory receptor 67", "refseq_ac": [ { "id": "NP_038647", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038647", "type": "external" } ], "gene_names_uniprotkb": "Or52z1; 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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Plays a central role in the initiation of the TC-NER process: specifically recognizes and binds RNA polymerase II stalled at a lesion, and mediates recruitment of ERCC8/CSA, initiating DNA damage excision by TFIIH recruitment. Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA. Acts as a chromatin remodeler at DSBs; DNA-dependent ATPase-dependent activity is essential for this function. Plays an important role in regulating the choice of the DNA double-strand breaks (DSBs) repair pathway and G2/M checkpoint activation; DNA-dependent ATPase activity is essential for this function. Regulates the DNA repair pathway choice by inhibiting non-homologous end joining (NHEJ), thereby promoting the homologous recombination (HR)-mediated repair of DSBs during the S/G2 phases of the cell cycle. Mediates the activation of the ATM- and CHEK2-dependent DNA damage responses thus preventing premature entry of cells into mitosis following the induction of DNA DSBs. Remodels chromatin by evicting histones from chromatin flanking DSBs, limiting RIF1 accumulation at DSBs thereby promoting BRCA1-mediated HR. Required for stable recruitment of ELOA and CUL5 to DNA damage sites. Also involved in UV-induced translocation of ERCC8 to the nuclear matrix. Essential for neuronal differentiation and neuritogenesis; regulates transcription and chromatin remodeling activities required during neurogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 20, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A3KMN2", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": 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{ "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.3.1.57", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.57", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.367", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.367", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0030296 protein tyrosine kinase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0008023 transcription 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} ], "gene_names_uniprotkb": "Or51v8; Olfr624", "gene_names_refseq": "MOR4-2P; Olfr624; Or51v8", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2PBJ9-6394126-6393197; olfactory receptor 624; olfactory receptor MOR4-2P", "tax_id": 10090, "disease": "", "pathway": " (mmu:258189)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell;GO:0071396 cellular response to lipid", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F8VQI7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "L7N226-1", "uniprot_id": [ { "id": "L7N226_MOUSE", "url": "https://www.uniprot.org/uniprot/L7N226", "type": "external" } ], "mass": 36536.0, "length": 321, "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r114", "organism": 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Nob5", "gene_names_refseq": "5330439C02Rik; Gpr158l1; Gpr179", "protein_names_uniprotkb": "G protein-coupled receptor 179", "protein_names_refseq": "G-protein coupled receptor 179 precursor; GPR158-like 1 receptor; probable G-protein coupled receptor 179", "tax_id": 10090, "disease": "congenital stationary night blindness 1E (Disease Ontology:DOID:0110869)", "pathway": " (mmu:217143)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "22325362;22689652;24084093;24114537;24415894;24790204;25613321;30282023;33922602;34333057;36613663", "class_list": "", "function": "Homodimerization of a proximal region within the C-terminus of the orphan G-protein coupled receptor GPR179., [RefSeq, PubMed]; Mice Lacking Gpr179 with Complete Congenital Stationary Night Blindness Are a Good Model for Myopia. Publication Status: Online-Only, [RefSeq, PubMed]; Orphan receptor involved in vision (PubMed:22325362, PubMed:24114537, PubMed:24790204, PubMed:30282023). Required for signal transduction through retinal depolarizing bipolar cells (PubMed:22325362, PubMed:24114537, PubMed:24790204, PubMed:33922602). Acts as an atypical G protein-coupled receptor that recruits and regulates the R7 group RGS-GNB5 complexes instead of activating G proteins: promotes the GTPase activator activity of R7 RGS proteins, increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:22689652, PubMed:24790204). Associates with components of metabotropic signaling cascade in retina ON-bipolar neurons, such as TRPM1 and GRM6: may control the ability of the GRM6 cascade to gate TRPM1 (PubMed:24114537, PubMed:24790204)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The loss of GPR179 in a mouse model of night blindness prevented targeting of RGS to the postsynaptic compartment of bipolar neurons in the retina, illuminating the role of GPR179 in night vision., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 4, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0051286 cell tip;GO:0030425 dendrite;GO:0045211 postsynaptic membrane;GO:0044292 dendrite terminus", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0007601 visual perception;GO:0009416 response to light stimulus", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "E9PY61-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q2M4-1", "uniprot_id": [ { "id": "E9Q2M4_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q2M4", "type": "external" } ], "mass": 54545.0, "length": 473, "protein_name": "Zinc finger protein 867", "gene_name": "Zfp867", "organism": "Mouse", "refseq_name": "zinc finger protein 867", "refseq_ac": [ { "id": "NP_848504", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848504", "type": "external" } ], "gene_names_uniprotkb": "Zfp867", "gene_names_refseq": "Zfp867", "protein_names_uniprotkb": "Zinc finger protein 867", "protein_names_refseq": "zinc finger protein 867; zinc finger protein LOC237775", "tax_id": 10090, "disease": "", "pathway": " (mmu:237775); (R-MMU-212436)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9Q2M4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q366-1", "uniprot_id": [ { "id": "E9Q366_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q366", "type": "external" } ], "mass": 34272.0, "length": 295, "protein_name": "Spermatogenesis associated glutamate (E)-rich protein 4f2", "gene_name": "Speer4f2", "organism": "Mouse", "refseq_name": "spermatogenesis associated glutamate (E)-rich protein 4f2", "refseq_ac": [ { "id": "NP_001361647", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001361647", "type": "external" } ], "gene_names_uniprotkb": "Speer4f2; Gm3495", "gene_names_refseq": "100041749; 100041832; Gm3495; Gm3535; Speer4f2", "protein_names_uniprotkb": "Spermatogenesis associated glutamate (E)-rich protein 4f2", "protein_names_refseq": "spermatogenesis associated glutamate (E)-rich protein 4f2", "tax_id": 10090, "disease": "", "pathway": " (mmu:100041749)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9Q366-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F2Z3U3-1", "uniprot_id": [ { "id": "F2Z3U3_MOUSE", "url": "https://www.uniprot.org/uniprot/F2Z3U3", "type": "external" } ], "mass": 136739.0, "length": 1266, "protein_name": "Ras association (RalGDS/AF-6) and pleckstrin homology domains 1", "gene_name": "Raph1", "organism": "Mouse", "refseq_name": "ras-associated and pleckstrin homology domains-containing protein 1", "refseq_ac": [ { "id": "NP_001038978", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038978", "type": "external" } ], "gene_names_uniprotkb": "Raph1", "gene_names_refseq": "9430025M21Rik; C730009O10Rik; Lpd; Raph1", "protein_names_uniprotkb": "Ras association (RalGDS/AF-6) and pleckstrin homology domains 1", "protein_names_refseq": "lamellipodin; ras-associated and pleckstrin homology domains-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:77300)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;17242355;21750661;21785421;25428506;28528544;34678516;37632751", "class_list": "", "function": "GSK3 and lamellipodin balance lamellipodial protrusions and focal adhesion maturation in mouse neural crest migration., [RefSeq, PubMed]; Role of lamellipodin (Lpd) in corticogenesis. Lpd depletion caused bipolar pyramidal neurons to adopt a tangential, rather than radial-glial, migration mode without affecting cell fate. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 0, "predicted_o_glycosites": 8, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0031252 cell leading edge", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0048675 axon extension;GO:0048858 cell projection morphogenesis;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "F2Z3U3-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000001000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F7C9P2-1", "uniprot_id": [ { "id": "F7C9P2_MOUSE", "url": "https://www.uniprot.org/uniprot/F7C9P2", "type": "external" } ], "mass": 53337.0, "length": 466, "protein_name": "F-box and WD-40 domain protein 25", "gene_name": "Fbxw25", "organism": "Mouse", "refseq_name": "F-box and WD-40 domain protein 25", "refseq_ac": [ { "id": "NP_001365572", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001365572", "type": "external" } ], "gene_names_uniprotkb": "Fbxw25; 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lysosomal membrane", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9Q343-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z5W0-1", "uniprot_id": [ { "id": "D3Z5W0_MOUSE", "url": "https://www.uniprot.org/uniprot/D3Z5W0", "type": "external" } ], "mass": 38153.0, "length": 336, "protein_name": "V-type proton ATPase subunit S1", "gene_name": "Atp6ap1l", "organism": "Mouse", "refseq_name": "V-type proton ATPase subunit S1-like protein precursor", "refseq_ac": [ { "id": "NP_001139351", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139351", "type": "external" } ], "gene_names_uniprotkb": "Atp6ap1l", "gene_names_refseq": "Atp6ap1l; EG435376", "protein_names_uniprotkb": "V-type proton ATPase subunit S1; V-ATPase Ac45 subunit; V-ATPase S1 accessory protein; Vacuolar proton pump 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Guides the V-type ATPase into specialized subcellular compartments, such as neuroendocrine regulated secretory vesicles or the ruffled border of the osteoclast, thereby regulating its activity. Involved in membrane trafficking and Ca(2+)-dependent membrane fusion. May play a role in the assembly of the V-type ATPase complex. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. In islets of Langerhans cells, may regulate the acidification of dense-core secretory granules., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0033176 proton-transporting V-type ATPase complex;GO:0005789 endoplasmic reticulum membrane;GO:0030665 clathrin-coated vesicle membrane;GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0030672 synaptic vesicle membrane", "go_biological_process": "GO:0030641 regulation of cellular pH;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3Z5W0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9QA16-1", "uniprot_id": [ { "id": "E9QA16_MOUSE", "url": "https://www.uniprot.org/uniprot/E9QA16", "type": "external" } ], "mass": 61836.0, "length": 536, "protein_name": "Caldesmon 1", "gene_name": "Cald1", "organism": "Mouse", "refseq_name": "caldesmon isoform 1", "refseq_ac": [ { "id": "NP_001334029", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334029", "type": "external" } ], "gene_names_uniprotkb": "Cald1", "gene_names_refseq": "4833423D12Rik; 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Gm7231; Sult2a7", "protein_names_uniprotkb": "Sulfotransferase; 2.8.2.-", "protein_names_refseq": "sulfotransferase family 2A member 1 family member", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (mmu:638251)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008146 sulfotransferase activity;GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding;GO:0004027 alcohol sulfotransferase activity;GO:0047704 bile-salt sulfotransferase activity;GO:0050294 steroid sulfotransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0051923 sulfation;GO:0008203 cholesterol metabolic process;GO:0006068 ethanol catabolic process;GO:0006805 xenobiotic metabolic process;GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A1B0GRF0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0U1RPT6-1", "uniprot_id": [ { "id": "A0A0U1RPT6_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A0U1RPT6", "type": "external" } ], "mass": 79455.0, "length": 723, "protein_name": "RIKEN cDNA 4930433I11 gene", "gene_name": "4930433I11Rik", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "4930433I11Rik", "gene_names_refseq": "", "protein_names_uniprotkb": "RIKEN cDNA 4930433I11 gene", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0U1RPT6-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1B0GR74-1", "uniprot_id": [ { "id": "A0A1B0GR74_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A1B0GR74", "type": "external" } ], "mass": 5936.0, "length": 53, "protein_name": "IgA inducing protein", "gene_name": "Igip", "organism": "Mouse", "refseq_name": "IgA-inducing protein homolog", "refseq_ac": [ { "id": "NP_001254725", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001254725", "type": "external" } ], "gene_names_uniprotkb": "Igip", "gene_names_refseq": "6330403M23Rik; 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In addition, participates in the glucocorticoid metabolism by catalyzing the NADPH-dependent cortisol/corticosterone into 20beta-dihydrocortisol (20b-DHF) or 20beta-corticosterone (20b-DHB), which are weak agonists of NR3C1 and NR3C2 in adipose tissue., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 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"protein_names_uniprotkb": "Predicted gene, 57857", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, 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activity;GO:0001537 dermatan 4-sulfotransferase activity;GO:0047756 chondroitin 4-sulfotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0016051 carbohydrate biosynthetic process;GO:0050650 chondroitin sulfate proteoglycan biosynthetic process;GO:0030166 proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3Z6E3-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000000000.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q0P0-1", "uniprot_id": [ { "id": "E9Q0P0_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q0P0", "type": "external" } ], "mass": 25319.0, "length": 211, "protein_name": "Predicted gene 8127", "gene_name": "Gm8127", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC666485", "refseq_ac": [ { "id": "NP_001365644", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001365644", "type": "external" } ], 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"total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9PWR6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9Q0P0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q2H5-1", "uniprot_id": [ { "id": "E9Q2H5_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q2H5", "type": "external" } ], "mass": 23428.0, "length": 230, "protein_name": "Keratin associated protein 10-21", "gene_name": "Krtap10-21", "organism": "Mouse", "refseq_name": "predicted protein 3233", "refseq_ac": [ { "id": "NP_001357760", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001357760", "type": "external" } ], "gene_names_uniprotkb": "Krtap10-21; Gm3233", "gene_names_refseq": "100041250; Gm3233; Krtap10-21", "protein_names_uniprotkb": "Keratin associated protein 10-21", "protein_names_refseq": "predicted protein 3233", "tax_id": 10090, "disease": "", "pathway": " (mmu:100041250); (R-MMU-6805567)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005829 cytosol;GO:0045095 keratin filament", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9Q2H5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q861-1", "uniprot_id": [ { "id": "E9Q861_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q861", "type": "external" } ], "mass": 36738.0, "length": 334, "protein_name": "C2 calcium-dependent domain containing 4A", "gene_name": "C2cd4a", "organism": "Mouse", "refseq_name": "C2 calcium-dependent domain-containing protein 4A", "refseq_ac": [ { "id": "NP_001156615", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156615", "type": "external" } ], "gene_names_uniprotkb": "C2cd4a", "gene_names_refseq": "C2cd4a; 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"10.1101/2023.09.13.557529;21750661;37981762", "class_list": "", "function": "Mosaic variegated aneuploidy syndrome with tetraploid, and predisposition to male infertility triggered by mutant CEP192., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, 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}, { "uniprot_canonical_ac": "E9PWW0-1", "uniprot_id": [ { "id": "E9PWW0_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PWW0", "type": "external" } ], "mass": 98821.0, "length": 856, "protein_name": "Vomeronasal 2, receptor 103", "gene_name": "Vmn2r103", "organism": "Mouse", "refseq_name": "vomeronasal receptor Vmn2r103", "refseq_ac": [ { "id": "NP_001098035", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098035", "type": "external" } ], "gene_names_uniprotkb": "Vmn2r103", "gene_names_refseq": "EG627636; Vmn103; Vmn2r103", "protein_names_uniprotkb": "Vomeronasal 2, receptor 103", "protein_names_refseq": "vomeronasal receptor Vmn2r103", "tax_id": 10090, "disease": "", "pathway": " (mmu:627636)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, 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protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9PWW0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JG36-1", "uniprot_id": [ { "id": "A0A0G2JG36_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A0G2JG36", "type": "external" } ], "mass": 12707.0, "length": 117, "protein_name": "Immunoglobulin kappa chain variable 14-100", "gene_name": "Igkv14-100", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Igkv14-100", "gene_names_refseq": "", "protein_names_uniprotkb": "Immunoglobulin kappa chain variable 14-100", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", 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0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2JG36-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AW66-1", "uniprot_id": [ { "id": "A2AW66_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AW66", "type": "external" } ], "mass": 41285.0, "length": 358, "protein_name": "Predicted gene 14322", "gene_name": "Gm14322", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC626802 isoform 1", "refseq_ac": [ { "id": "NP_001230832", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001230832", "type": "external" } ], "gene_names_uniprotkb": "Gm14322", "gene_names_refseq": "Gm14322", "protein_names_uniprotkb": "Predicted gene 14322", "protein_names_refseq": "uncharacterized protein LOC626802 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:626802)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2AW66-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A075B635-1", "uniprot_id": [ { "id": "A0A075B635_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A075B635", "type": "external" } ], "mass": 9914.0, "length": 89, "protein_name": "T cell receptor alpha variable 13N-4", "gene_name": "Trav13n-4", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Trav13n-4", "gene_names_refseq": "", "protein_names_uniprotkb": "T cell receptor alpha variable 13N-4", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0042101 T cell receptor complex", "go_biological_process": "GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A075B635-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3UXE9-1", "uniprot_id": [ { "id": "G3UXE9_MOUSE", "url": "https://www.uniprot.org/uniprot/G3UXE9", "type": "external" } ], "mass": 44661.0, "length": 396, "protein_name": "Histocompatibility 2, T region locus 5", "gene_name": "H2-T5", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "H2-T5", "gene_names_refseq": "", "protein_names_uniprotkb": "Histocompatibility 2, T region locus 5", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;21750661", "class_list": "", "function": "Involved in the presentation of foreign antigens to the immune system., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0030881 beta-2-microglobulin binding;GO:0042605 peptide antigen binding", "go_cellular_component": "GO:0030670 phagocytic vesicle membrane;GO:0042612 MHC class I protein complex;GO:0098553 lumenal side of endoplasmic reticulum membrane;GO:0005615 extracellular space;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0002474 antigen processing and presentation of peptide antigen via MHC class I;GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0006955 immune response;GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0001916 positive regulation of T cell mediated cytotoxicity", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "G3UXE9-1", "record_type": "protein", "filter_code": "0000000.1000100.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P39688-1", "uniprot_id": [ { "id": "FYN_MOUSE", "url": "https://www.uniprot.org/uniprot/P39688", "type": "external" } ], "mass": 60675.0, "length": 537, "protein_name": "Tyrosine-protein kinase Fyn", "gene_name": "Fyn", "organism": "Mouse", "refseq_name": "tyrosine-protein kinase Fyn isoform b", "refseq_ac": [ { "id": "NP_001116364", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116364", "type": "external" } ], "gene_names_uniprotkb": "Fyn", "gene_names_refseq": "Fyn", "protein_names_uniprotkb": "Tyrosine-protein kinase Fyn; 2.7.10.2; Proto-oncogene c-Fyn; p59-Fyn", "protein_names_refseq": "Fyn proto-oncogene; Src Kinase p59; p59-Fyn; proto-oncogene c-Fyn; proto-oncogene tyrosine-protein kinase Fyn; tyrosine-protein kinase Fyn isoform b", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); intestinal cancer (Disease Ontology:DOID:10155); Alzheimer's disease (Disease Ontology:DOID:10652); asthma (Disease Ontology:DOID:2841); Goldenhar syndrome (Disease Ontology:DOID:2907); skin squamous cell carcinoma (Disease Ontology:DOID:3151); temporal lobe epilepsy (Disease Ontology:DOID:3328); skin disease (Disease Ontology:DOID:37); schizophrenia (Disease Ontology:DOID:5419); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:14360); (R-MMU-114604); (R-MMU-1227986); (R-MMU-1257604); (R-MMU-1433557); (R-MMU-1433559); (R-MMU-2029481); (R-MMU-210990); (R-MMU-2424491); (R-MMU-373753); (R-MMU-375165); (R-MMU-389356); (R-MMU-389357); (R-MMU-389359); (R-MMU-389513); (R-MMU-3928662); (R-MMU-3928663); (R-MMU-3928664); (R-MMU-3928665); (R-MMU-399954); (R-MMU-399955); (R-MMU-399956); (R-MMU-418885); (R-MMU-4420097); (R-MMU-5621480); (R-MMU-5621575); (R-MMU-5673001); (R-MMU-6811558); (R-MMU-75892); (R-MMU-8866376); (R-MMU-9032759); (R-MMU-912631); (R-MMU-9766229)", "pathway_count": 33, "publication_count": 41, "publication_id_list": "10.1101/2023.09.13.557529;11711534;12218089;12526739;12640114;12681493;1361685;14645715;14999081;16129412;16966330;18034455;19144319;19786542;19956733;20398064;20658524;21750661;21872217;22685302;2488273;26224309;26740625;27859601;28912680;31698056;32998341;37828378;38430221;7681396;7980442;8007959;8168489;8413237;8441403;8631859;8655574;9201723;9312046;9425276;9895129", "class_list": "", "function": "Fat mass and obesity associated protein inhibits neuronal ferroptosis via the FYN/Drp1 axis and alleviate cerebral ischemia/reperfusion injury., [RefSeq, PubMed]; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance (PubMed:12218089, PubMed:12526739, PubMed:12640114, PubMed:12681493, PubMed:14999081, PubMed:8007959). Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain (By similarity). Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions (By similarity). Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin) (PubMed:12640114). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT (By similarity). Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage (By similarity). Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6 (By similarity). Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein (By similarity). Involved in reelin signaling by mediating phosphorylation of DAB1 following reelin (RELN)-binding to its receptor (PubMed:12526739). Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation (By similarity). Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation (By similarity). Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1 and PDCD1 (By similarity). Phosphorylation of PAG1 promotes interaction between PAG1 and CSK and recruitment of CSK to lipid rafts (By similarity). Phosphorylation of PDCD1 leads to the recruitment of PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules (By similarity). CSK maintains LCK and FYN in an inactive form (PubMed:12218089). Promotes CD28-induced phosphorylation of VAV1 (By similarity). In mast cells, phosphorylates CLNK after activation of immunoglobulin epsilon receptor signaling (PubMed:12681493). Can also promote CD244-mediated NK cell activation (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TAT3;Q3U0T5;Q8K2A3", "ec_number_list": [ { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005102 signaling receptor binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005768 endosome;GO:0005829 cytosol", "go_biological_process": "GO:0010730 negative regulation of hydrogen peroxide biosynthetic process;GO:0006468 protein phosphorylation;GO:0007166 cell surface receptor signaling pathway;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 4.4, "record_id": "P39688-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CPW0-1", "uniprot_id": [ { "id": "CNTP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CPW0", "type": "external" } ], "mass": 148197.0, "length": 1332, "protein_name": "Contactin-associated protein-like 2", "gene_name": "Cntnap2", "organism": "Mouse", "refseq_name": "contactin-associated protein-like 2 isoform a precursor", "refseq_ac": [ { "id": "NP_001004357", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004357", "type": "external" } ], "gene_names_uniprotkb": "Cntnap2; Kiaa0868", "gene_names_refseq": "5430425M22Rik; Caspr2; Cntnap2; mKIAA0868", "protein_names_uniprotkb": "Contactin-associated protein-like 2; Cell recognition molecule Caspr2", "protein_names_refseq": "cell recognition molecule Caspr2; contactin-associated protein-like 2 isoform a precursor", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); specific language impairment (Disease Ontology:DOID:0060244); autosomal recessive intellectual developmental disorder (Disease Ontology:DOID:0060308); cortical dysplasia-focal epilepsy syndrome (Disease Ontology:DOID:0090130); social phobia (Disease Ontology:DOID:11257); autistic disorder (Disease Ontology:DOID:12849); reading disorder (Disease Ontology:DOID:13365); major depressive disorder (Disease Ontology:DOID:1470); epilepsy (Disease Ontology:DOID:1826); articulation disorder (Disease Ontology:DOID:4186); mutism (Disease Ontology:DOID:4189); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:66797)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;11567047;21183079;21750661;25378149;30031227;30899004;33300544;34203471", "class_list": "", "function": "Required for gap junction formation (By similarity). Required, with CNTNAP1, for radial and longitudinal organization of myelinated axons (PubMed:25378149). Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the juxtaparanodal region of the axo-glial junction (Probable) (PubMed:25378149)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 9, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 9, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 9, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 9, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 23, "disease_count": 12, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "Q6P2K4;Q6ZQ31", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0019899 enzyme binding;GO:0044325 transmembrane transporter binding;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005769 early endosome;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0001964 startle response;GO:1904861 excitatory synapse assembly;GO:0098976 excitatory chemical synaptic transmission;GO:0001701 in utero embryonic development;GO:0006954 inflammatory response", "synthesized_glycan_count": 0, "hit_score": 4.3, "record_id": "Q9CPW0-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K2Y9-1", "uniprot_id": [ { "id": "CCM2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K2Y9", "type": "external" } ], "mass": 49917.0, "length": 453, "protein_name": "Cerebral cavernous malformations protein 2 homolog", "gene_name": "Ccm2", "organism": "Mouse", "refseq_name": "cerebral cavernous malformations protein 2 homolog isoform 1", "refseq_ac": [ { "id": "NP_666126", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666126", "type": "external" } ], "gene_names_uniprotkb": "Ccm2; Osm", "gene_names_refseq": "Ccm2", "protein_names_uniprotkb": "Cerebral cavernous malformations protein 2 homolog; Malcavernin; Osmosensing scaffold for MEKK3", "protein_names_refseq": "cerebral cavernous malformation 2 homolog; cerebral cavernous malformations protein 2 homolog isoform 1; cerebral cavernous malformations protein 2 homolog; malcavernin; osmosensing scaffold for MEKK3", "tax_id": 10090, "disease": "cerebral cavernous malformation (Disease Ontology:DOID:0060669); cerebral cavernous malformation 2 (Disease Ontology:DOID:0060670)", "pathway": " (mmu:216527)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "14634666;16037064;16373645;16465592;17242355;19151727;21183079;21750661;25428506;30084848;31219806;33300544;34203471;34428180;36210013;38293758", "class_list": "", "function": "CCM1 and CCM2 have similar expression patterns during development and are involved in the same pathway important for central nervous system vascular development, [RefSeq, PubMed]; CCM1 associates with CCM2, indicating that the genetic heterogeneity observed in familial cavernous malformation pathogenesis may reflect mutation of different molecular members of a coordinated signaling complex., [RefSeq, PubMed]; Ccm2 is expressed in neurons and choroid plexus but not in vascular endothelium of small vessels in the brain., [RefSeq, PubMed]; Cerebral cavernous malformation proteins, CCM1, CCM2 and CCM3, are decreased in metastatic lesions in a murine breast carcinoma model., [RefSeq, PubMed]; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions. May also function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5SUA3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0032991 protein-containing complex", "go_biological_process": "GO:0001570 vasculogenesis;GO:0001701 in utero embryonic development;GO:0007507 heart development;GO:0035264 multicellular organism growth;GO:0001568 blood vessel development", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q8K2Y9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64096-1", "uniprot_id": [ { "id": "MCF2L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64096", "type": "external" } ], "mass": 129113.0, "length": 1149, "protein_name": "Guanine nucleotide exchange factor DBS", "gene_name": "Mcf2l", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mcf2l; Dbs", "gene_names_refseq": "", "protein_names_uniprotkb": "Guanine nucleotide exchange factor DBS; DBL's big sister; MCF2-transforming sequence-like protein", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:17207); (R-MMU-193648); (R-MMU-416482); (R-MMU-8980692); (R-MMU-9013026); (R-MMU-9013106); (R-MMU-9013148); (R-MMU-9013149); (R-MMU-9013408)", "pathway_count": 9, "publication_count": 11, "publication_id_list": "11889037;12006984;15274927;15345747;17000758;21183079;21750661;34203471;34428180;35820727;7862449", "class_list": "", "function": "Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways (PubMed:11889037, PubMed:12006984, PubMed:17000758). Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9PV70", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0005545 1-phosphatidylinositol binding;GO:0035091 phosphatidylinositol binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0030027 lamellipodium;GO:0031234 extrinsic component of cytoplasmic side of plasma membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007266 Rho protein signal transduction;GO:0035025 positive regulation of Rho protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q64096-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64702-1", "uniprot_id": [ { "id": "PLK4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64702", "type": "external" } ], "mass": 103746.0, "length": 925, "protein_name": "Serine/threonine-protein kinase PLK4", "gene_name": "Plk4", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase PLK4 isoform 1", "refseq_ac": [ { "id": "NP_035625", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035625", "type": "external" } ], "gene_names_uniprotkb": "Plk4; Sak; Stk18", "gene_names_refseq": "1700028H20; Plk4; Sak; Stk18", "protein_names_uniprotkb": "Serine/threonine-protein kinase PLK4; 2.7.11.21; PLK-4; Polo-like kinase 4; Serine/threonine-protein kinase 18; Serine/threonine-protein kinase Sak", "protein_names_refseq": "serine/threonine kinase 18; serine/threonine-protein kinase 18; serine/threonine-protein kinase PLK4 isoform 1; serine/threonine-protein kinase Plk4; serine/threonine-protein kinase Sak", "tax_id": 10090, "disease": "ciliopathy (Disease Ontology:DOID:0060340); microcephaly and chorioretinopathy 2 (Disease Ontology:DOID:0080106); colon cancer (Disease Ontology:DOID:219); breast ductal carcinoma (Disease Ontology:DOID:3007); hepatocellular carcinoma (Disease Ontology:DOID:684); diabetic retinopathy (Disease Ontology:DOID:8947)", "pathway": " (mmu:20873); (R-MMU-2565942); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-5620912); (R-MMU-8854518)", "pathway_count": 8, "publication_count": 13, "publication_id_list": "11301255;12352953;16025114;17891141;21750661;24240477;25428506;34428180;36067731;37738460;40021952;8022793;8756623", "class_list": "", "function": "2.0 A crystal structure of a novel domain composed of the polo box motif of murine Sak, [RefSeq, PubMed]; Expression Analyses of Polo-Like Kinase 4, a Gene Product Responsible for Autosomal Recessive Microcephaly and Seckel Syndrome, during Mouse Brain Development., [RefSeq, PubMed]; Inhibition of PLK4 remodels histone methylation and activates the immune response via the cGAS-STING pathway in TP53-mutated AML., [RefSeq, PubMed]; Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Phosphorylates CDC25C and CHEK2. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (By similarity). Phosphorylates CEP131 at 'Ser-78' and PCM1 at 'Ser-372' which is essential for proper organization and integrity of centriolar satellites (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to the nucleolus during G2, to centrosomes during G2/M, and to the cleavage furrow during cytokinesis. It is required for progression through mitosis, cell survival, and embryonic development. The mouse genome contains a pseudogene similar to this gene. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UVA3;Q6PEP6;Q78EG6;Q80UT6;Q8R0I5;Q9CVR6;Q9CVU6", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0106310 protein serine kinase activity;GO:0004672 protein kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0032154 cleavage furrow", "go_biological_process": "GO:0046601 positive regulation of centriole replication;GO:0006468 protein phosphorylation;GO:0060271 cilium assembly;GO:0060707 trophoblast giant cell differentiation;GO:0007099 centriole replication", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q64702-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30282-1", "uniprot_id": [ { "id": "CCND3_MOUSE", "url": "https://www.uniprot.org/uniprot/P30282", "type": "external" } ], "mass": 32411.0, "length": 292, "protein_name": "G1/S-specific cyclin-D3", "gene_name": "Ccnd3", "organism": "Mouse", "refseq_name": "G1/S-specific cyclin-D3", "refseq_ac": [ { "id": "NP_001075104", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075104", "type": "external" } ], "gene_names_uniprotkb": "Ccnd3; Cyl-3", "gene_names_refseq": "9230106B05Rik; Ccnd3", "protein_names_uniprotkb": "G1/S-specific cyclin-D3", "protein_names_refseq": "G1/S-specific cyclin-D3", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); polycystic ovary syndrome (Disease Ontology:DOID:11612); cervix carcinoma (Disease Ontology:DOID:2893); invasive ductal carcinoma (Disease Ontology:DOID:3008); ovary adenocarcinoma (Disease Ontology:DOID:3713); renal cell carcinoma (Disease Ontology:DOID:4450); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (mmu:12445); (R-MMU-5687128); (R-MMU-69231); (R-MMU-8934593); (R-MMU-9754119)", "pathway_count": 5, "publication_count": 17, "publication_id_list": "1827757;18299400;20173027;21183079;21750661;22872234;25428506;26008897;30084848;33207194;33854232;33854235;34428180;35820727;37828378;38117277;8661116", "class_list": "", "function": "Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Shows transcriptional coactivator activity with ATF5 independently of CDK4., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The Cyclin D3 Protein Enforces Monogenic TCRbeta Expression by Mediating TCRbeta Protein-Signaled Feedback Inhibition of Vbeta Recombination., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q62391;Q99KP2", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0043539 protein serine/threonine kinase activator activity;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity;GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005815 microtubule organizing center", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007165 signal transduction;GO:0008284 positive regulation of cell population proliferation;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P30282-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22682-1", "uniprot_id": [ { "id": "CBL_MOUSE", "url": "https://www.uniprot.org/uniprot/P22682", "type": "external" } ], "mass": 100564.0, "length": 913, "protein_name": "E3 ubiquitin-protein ligase CBL", "gene_name": "Cbl", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase CBL", "refseq_ac": [ { "id": "NP_031645", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031645", "type": "external" } ], "gene_names_uniprotkb": "Cbl", "gene_names_refseq": "4732447J05Rik; Cbl-2; Cbl; c-Cbl", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase CBL; 2.3.2.27; Casitas B-lineage lymphoma proto-oncogene; Proto-oncogene c-Cbl; RING-type E3 ubiquitin transferase CBL; Signal transduction protein CBL", "protein_names_refseq": "E3 ubiquitin-protein ligase CBL; RING-type E3 ubiquitin transferase CBL; casitas B-lineage lymphoma proto-oncogene; proto-oncogene c-CBL; signal transduction protein CBL", "tax_id": 10090, "disease": "juvenile myelomonocytic leukemia (Disease Ontology:DOID:0050458); myeloid neoplasm (Disease Ontology:DOID:0070004); myeloproliferative neoplasm (Disease Ontology:DOID:2226); transient cerebral ischemia (Disease Ontology:DOID:224); osteosarcoma (Disease Ontology:DOID:3347); Noonan syndrome (Disease Ontology:DOID:3490); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hyperglycemia (Disease Ontology:DOID:4195); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); multiple myeloma (Disease Ontology:DOID:9538); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:12402); (R-MMU-1059683); (R-MMU-1295596); (R-MMU-1433559); (R-MMU-182971); (R-MMU-2173789); (R-MMU-5654726); (R-MMU-5654727); (R-MMU-5654732); (R-MMU-5654733); (R-MMU-6807004); (R-MMU-8849469); (R-MMU-8856825); (R-MMU-8856828); (R-MMU-912631); (R-MMU-9706369)", "pathway_count": 16, "publication_count": 41, "publication_id_list": "10092522;10393178;12024036;12649282;12842890;15001553;17353186;17620338;17947660;18034775;18602463;19265199;20100865;2030914;20485683;20851882;21183079;21750661;21830225;21952831;23374343;28011936;29237719;29589748;31219806;32782141;33725478;34428180;36210013;36852467;37828378;38752545;38761804;39413134;39627609;7782294;8551236;8798454;9447983;9653117;9722576", "class_list": "", "function": "BLNK negatively regulates innate antifungal immunity through inhibiting c-Cbl-mediated macrophage migration., [RefSeq, PubMed]; C-Cbl induced podocin ubiquitination contributes to the podocytes injury in diabetic nephropathy., [RefSeq, PubMed]; Deficiency of CBL and CBLB ubiquitin ligases leads to hyper T follicular helper cell responses and lupus by reducing BCL6 degradation., [RefSeq, PubMed]; E3 ubiquitin-protein ligase that acts as a negative regulator of many signaling pathways by mediating ubiquitination of cell surface receptors (PubMed:10393178, PubMed:12649282, PubMed:19265199, PubMed:20100865, PubMed:9653117). Accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome (PubMed:12649282, PubMed:20100865). Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, CSF1R, EPHA8 and KDR and mediates their ubiquitination to terminate signaling (PubMed:19265199). Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation (By similarity). Ubiquitinates EGFR and SPRY2 (By similarity). Involved in LAG3-mediated inhibition of TCR signaling: following ligand-binding to LAG3, catalyzes 'Lys-63'-linked ubiquitination of LAG3, unleashing the LAG3 C-terminus from the membrane, and initiating a signaling that prevents TCR activation (By similarity). Ubiquitinates NECTIN1 following association between NECTIN1 and herpes simplex virus 1/HHV-1 envelope glycoprotein D, leading to NECTIN1 removal from cell surface (By similarity). Participates in signal transduction in hematopoietic cells (By similarity). Plays an important role in the regulation of osteoblast differentiation and apoptosis (By similarity). Essential for osteoclastic bone resorption (By similarity). The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (By similarity). In association with CBLB, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (PubMed:29237719)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 16, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 15, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3U527;Q8CEA1", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.30", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" } ], "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0008270 zinc ion binding;GO:0017124 SH3 domain binding;GO:0019901 protein kinase binding;GO:0046875 ephrin receptor binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005925 focal adhesion", "go_biological_process": "GO:0032487 regulation of Rap protein signal transduction;GO:0006468 protein phosphorylation;GO:0007165 signal transduction;GO:0007166 cell surface receptor signaling pathway;GO:0010332 response to gamma radiation", "synthesized_glycan_count": 0, "hit_score": 4.6, "record_id": "P22682-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63034-1", "uniprot_id": [ { "id": "CYH2_MOUSE", "url": "https://www.uniprot.org/uniprot/P63034", "type": "external" } ], "mass": 46571.0, "length": 400, "protein_name": "Cytohesin-2", "gene_name": "Cyth2", "organism": "Mouse", "refseq_name": "cytohesin-2 isoform 2", "refseq_ac": [ { "id": "NP_001106171", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106171", "type": "external" } ], "gene_names_uniprotkb": "Cyth2; Pscd2; Sec7b", "gene_names_refseq": "ARNO; CLM2; Cyth2; Pscd2", "protein_names_uniprotkb": "Cytohesin-2; ARF nucleotide-binding site opener; CLM2; PH, SEC7 and coiled-coil domain-containing protein 2; Protein ARNO; SEC7 homolog B; mSec7-2", "protein_names_refseq": "ARF nucleotide-binding site opener; PH, SEC7 and coiled-coil domain-containing protein 2; SEC7 homolog B; cytohesin-2 isoform 2; mSec7-2; pleckstrin homology, Sec7 and coiled-coil domains 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:19158)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15359279;18042453;20080746;21750661;25326380;34390832;34800437;35077201;35095899;9744817", "class_list": "", "function": "Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Activates ARF factors through replacement of GDP with GTP (PubMed:18042453). The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane (By similarity). Involved in neurite growth (PubMed:25326380)., [UniProtKB, PubMed, UniProtKB, PubMed]; Cytohesin-2 mediates group I metabotropic glutamate receptor-dependent mechanical allodynia through the activation of ADP ribosylation factor 6 in the spinal cord., [RefSeq, PubMed]; Cytohesin-2/ARNO: A Novel Bridge Between Cell Migration and Immunoregulation in Synovial Fibroblasts. Publication Status: Online-Only, [RefSeq, PubMed]; The adaptor SH2B1 and the phosphatase PTP4A1 regulate the phosphorylation of cytohesin-2 in myelinating Schwann cells in mice., [RefSeq, PubMed]; The synaptic scaffolding protein CNKSR2 interacts with CYTH2 to mediate hippocampal granule cell development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QJX3;O89099;P97695;Q3UP39", "ec_number_list": [], "go_molecular_function": "GO:0070679 inositol 1,4,5 trisphosphate binding;GO:0008289 lipid binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005912 adherens junction", "go_biological_process": "GO:0030155 regulation of cell adhesion;GO:2000171 negative regulation of dendrite development;GO:0032012 regulation of ARF protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P63034-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24452-1", "uniprot_id": [ { "id": "CAPG_MOUSE", "url": "https://www.uniprot.org/uniprot/P24452", "type": "external" } ], "mass": 39240.0, "length": 352, "protein_name": "Macrophage-capping protein", "gene_name": "Capg", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Capg; Mbh1", "gene_names_refseq": "", "protein_names_uniprotkb": "Macrophage-capping protein; Actin regulatory protein CAP-G; Actin-capping protein GCAP39; Myc basic motif homolog 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 11, "publication_id_list": "1849072;21183079;21750661;2211671;2255912;32152506;34428180;36210013;36288343;37507081;8293478", "class_list": "", "function": "Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA. Uncapping occurs either when Ca(2+) falls or when the concentration of polyphosphoinositide rises, both at low and high Ca(2+)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0019904 protein domain specific binding;GO:0051015 actin filament binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0007417 central nervous system development;GO:0051016 barbed-end actin filament capping;GO:0008154 actin polymerization or depolymerization;GO:0071346 cellular response to type II interferon;GO:0051014 actin filament severing", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P24452-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80XN0-1", "uniprot_id": [ { "id": "BDH_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80XN0", "type": "external" } ], "mass": 38299.0, "length": 343, "protein_name": "D-beta-hydroxybutyrate dehydrogenase, mitochondrial", "gene_name": "Bdh1", "organism": "Mouse", "refseq_name": "D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001116155", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116155", "type": "external" } ], "gene_names_uniprotkb": "Bdh1; Bdh", "gene_names_refseq": "2310032J20Rik; Bdh1; Bdh", "protein_names_uniprotkb": "D-beta-hydroxybutyrate dehydrogenase, mitochondrial; 1.1.1.30; 3-hydroxybutyrate dehydrogenase; BDH", "protein_names_refseq": "3-hydroxybutyrate dehydrogenase (heart, mitochondrial); D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor; D-beta-hydroxybutyrate dehydrogenase, mitochondrial; b-hydroxybutyrate dehydrogenase", "tax_id": 10090, "disease": "chromosome 3q29 microdeletion syndrome (Disease Ontology:DOID:0060419); COVID-19 (Disease Ontology:DOID:0080600); hyperthyroidism (Disease Ontology:DOID:7998)", "pathway": " (mmu:71911); (R-MMU-77108); (R-MMU-77111); (R-MMU-9837999)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "21750661;23576753;23806337;25428506;30084848;32750298;33300544;34428180;36288343;37453647;37507081;38015723", "class_list": "", "function": "BDH1-mediated betaOHB metabolism ameliorates diabetic kidney disease by activation of NRF2-mediated antioxidative pathway., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UJS9;Q3UL45;Q8BK53;Q8R0C8", "ec_number_list": [ { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.104", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.104", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.1.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.38", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "1.1.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.41", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" } ], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0003858 3-hydroxybutyrate dehydrogenase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0099617 matrix side of mitochondrial inner membrane", "go_biological_process": "GO:0008202 steroid metabolic process;GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q80XN0-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08607-1", "uniprot_id": [ { "id": "C4BPA_MOUSE", "url": "https://www.uniprot.org/uniprot/P08607", "type": "external" } ], "mass": 51524.0, "length": 469, "protein_name": "C4b-binding protein", "gene_name": "C4bpa; C4bp", "organism": "Mouse", "refseq_name": "C4b-binding protein isoform 1 precursor", "refseq_ac": [ { "id": "NP_031602", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031602", "type": "external" } ], "gene_names_uniprotkb": "C4bpa; C4bp; C4bp", "gene_names_refseq": "C4bpa; C4bp", "protein_names_uniprotkb": "C4b-binding protein; C4bp", "protein_names_refseq": "C4b-binding protein isoform 1 precursor; C4b-binding protein", "tax_id": 10090, "disease": "COVID-19 (Disease Ontology:DOID:0080600)", "pathway": " (mmu:12269)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;17330941;20571061;21750661;27794068;28542817;34428180;35547734;3663616;37283747", "class_list": "", "function": "C4b-binding protein inhibits particulate- and crystalline-induced NLRP3 inflammasome activation. Publication Status: Online-Only, [RefSeq, PubMed]; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It also interacts with serum amyloid P component., [UniProtKB]; Data suggest that C4bp prevents interaction between Tlr4/MD-2 and its ligand; C4bp does not appear to interact with Tlr3; C4bp binds to macrophage surface Tlr4 and inhibits Tlr/Tlr ligand interaction, thereby inhibiting Tlr4 activation. (C4bp = complement component 4 binding protein; Tlr = toll-like receptor; MD-2 = myeloid differentiation protein-2), [RefSeq, PubMed]; The Hidden Side of Complement Regulator C4BP: Dissection and Evaluation of Its Immunomodulatory Activity. Publication Status: Online-Only, [RefSeq, PubMed]; This study shows that C4BP binds to TLR2, inhibits TLR1/2 ligand binding and reduces cytokine production, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 1128, "biomarker_type": "", "glycan_count": 4, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q91X48", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0045087 innate immune response;GO:0045959 negative regulation of complement activation, classical pathway;GO:0002456 T cell mediated immunity;GO:0006958 complement activation, classical pathway", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P08607-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P14211-1", "uniprot_id": [ { "id": "CALR_MOUSE", "url": "https://www.uniprot.org/uniprot/P14211", "type": "external" } ], "mass": 47995.0, "length": 416, "protein_name": "Calreticulin", "gene_name": "Calr", "organism": "Mouse", "refseq_name": "calreticulin precursor", "refseq_ac": [ { "id": "NP_031617", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031617", "type": "external" } ], "gene_names_uniprotkb": "Calr", "gene_names_refseq": "CRT; Calregulin; Calr", "protein_names_uniprotkb": "Calreticulin; CRP55; Calregulin; ERp60; Endoplasmic reticulum resident protein 60; HACBP", "protein_names_refseq": "CRP55; ERp60; HACBP; calreticulin precursor; endoplasmic reticulum resident protein 60", "tax_id": 10090, "disease": "vitamin B12 deficiency (Disease Ontology:DOID:0050731); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); stomach cancer (Disease Ontology:DOID:10534); lung cancer (Disease Ontology:DOID:1324); Parkinson's disease (Disease Ontology:DOID:14330); colon carcinoma (Disease Ontology:DOID:1520); neuroendocrine tumor (Disease Ontology:DOID:169); colon cancer (Disease Ontology:DOID:219); essential thrombocythemia (Disease Ontology:DOID:2224); thrombocytosis (Disease Ontology:DOID:2228); ovarian cancer (Disease Ontology:DOID:2394); gallbladder cancer (Disease Ontology:DOID:3121); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); myelofibrosis (Disease Ontology:DOID:4971); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); Burkitt lymphoma (Disease Ontology:DOID:8584); sideroblastic anemia (Disease Ontology:DOID:8955); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (mmu:12317); (R-MMU-3000480); (R-MMU-901042); (R-MMU-983170)", "pathway_count": 4, "publication_count": 21, "publication_id_list": "1398135;16931514;20801878;20880849;21652723;23806337;24256100;25428506;25605945;2583110;26740625;30779550;30899004;34428180;35984892;36288343;37453647;37507081;38853260;7523108;8418194", "class_list": "glycogene", "function": "Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (PubMed:20880849, PubMed:21652723). Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (By similarity). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed]; Neutrophil-specific expression of JAK2-V617F or CALRmut induces distinct inflammatory profiles in myeloproliferative neoplasia. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 19, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 25, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TVD2", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0005178 integrin binding;GO:0005506 iron ion binding;GO:0051082 unfolded protein binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005635 nuclear envelope", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:0008284 positive regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0045665 negative regulation of neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P14211-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000000.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05A80-1", "uniprot_id": [ { "id": "CAPR2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q05A80", "type": "external" } ], "mass": 114491.0, "length": 1031, "protein_name": "Caprin-2", "gene_name": "Caprin2", "organism": "Mouse", "refseq_name": "caprin-2 isoform 2", "refseq_ac": [ { "id": "NP_001288280", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001288280", "type": "external" } ], "gene_names_uniprotkb": "Caprin2; C1qdc1; Kiaa1873; Rng140", "gene_names_refseq": "Adir; C1qdc1; Caprin2; Eeg1; rng140", "protein_names_uniprotkb": "Caprin-2; C1q domain-containing protein 1; Cytoplasmic activation/proliferation-associated protein 2; RNA granule protein 140", "protein_names_refseq": "C1q domain containing 1; C1q domain-containing protein 1; RNA granule protein 140; adiponectin r; caprin-2 isoform 2; caprin-2; cytoplasmic activation/proliferation-associated protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:232560)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "19275872;20516077;21183079;21540332;21750661;22645316;26177727;30084848;31219806;32839273;34428180;34678516;36852467", "class_list": "", "function": "Functions in distinct morphological events in mammalian eye development, [RefSeq, PubMed]; Implications of RNG140 (caprin2)-mediated translational regulation in eye lens differentiation., [RefSeq, PubMed]; Promotes phosphorylation of the Wnt coreceptor LRP6, leading to increased activity of the canonical Wnt signaling pathway (By similarity). Facilitates constitutive LRP6 phosphorylation by CDK14/CCNY during G2/M stage of the cell cycle, which may potentiate cells for Wnt signaling (By similarity). May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons (PubMed:20516077). Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation (By similarity). May be involved in apoptosis (By similarity)., [UniProtKB, UniProtKB, PubMed]; RNG140 has roles in the maintenance of the dendritic structure in the adult vertebrate brain through localizing to a kind of RNA granules that are distinct from RNG105-containing granules, [RefSeq, PubMed]; The authors have isolated and characterized mouse cytoplasmic activation/proliferation-associated protein-2 (Caprin2), with domains belonging to both the Caprin family and the C1q and tumour necrosis factor (TNF) super-family, [RefSeq, PubMed]; This gene encodes a member of the caprin family. The encoded protein may function as an RNA-binding protein that induces the formation of RNA granules and plays an important role in brain function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 8, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 8, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 8, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q58E31;Q6ZPG7", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0005102 signaling receptor binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0030308 negative regulation of cell growth;GO:0017148 negative regulation of translation;GO:0050775 positive regulation of dendrite morphogenesis", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q05A80-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VHC5-1", "uniprot_id": [ { "id": "CABP4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VHC5", "type": "external" } ], "mass": 30268.0, "length": 271, "protein_name": "Calcium-binding protein 4", "gene_name": "Cabp4", "organism": "Mouse", "refseq_name": "calcium-binding protein 4", "refseq_ac": [ { "id": "NP_653115", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_653115", "type": "external" } ], "gene_names_uniprotkb": "Cabp4", "gene_names_refseq": "2410038D05Rik; Cabp4", "protein_names_uniprotkb": "Calcium-binding protein 4; CaBP4", "protein_names_refseq": "calcium-binding protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:73660)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15452577;16249514;17050707;17947313;18003854;18296658;23341017;25258313", "class_list": "", "function": "CaBP4 forms a collapsed structure around the IQ motif in Cav1.4 that may promote channel activation by disrupting an interaction between IQ and the inhibitor of Ca(2+)-dependent inactivation domain, [RefSeq, PubMed]; Important for normal synaptic function, probably through regulation of Ca(2+) influx and neurotransmitter release in photoreceptor synaptic terminals, [RefSeq, PubMed]; Involved in normal synaptic function through regulation of Ca(2+) influx and neurotransmitter release in photoreceptor synaptic terminals and in auditory transmission. Modulator of CACNA1D and CACNA1F, suppressing the calcium-dependent inactivation and shifting the activation range to more hyperpolarized voltages., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Our results implicate CaBP1 rather than CaBP4 in conferring the anomalous slow inactivation of Ca(v)1.3 Ca(2+) currents required for auditory transmission, [RefSeq, PubMed]; These findings demonstrate how light-stimulated changes in CaBP4 phosphorylation and Ca2+ binding may regulate presynaptic Ca2+ signals in photoreceptors., [RefSeq, PubMed]; This study provides evidence that CaBP4 is dephosphorylated by PP2A in the retina. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005246 calcium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005829 cytosol;GO:0098793 presynapse", "go_biological_process": "GO:0007601 visual perception;GO:0007605 sensory perception of sound;GO:0007602 phototransduction;GO:0008594 photoreceptor cell morphogenesis;GO:0046549 retinal cone cell development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8VHC5-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VHV1-1", "uniprot_id": [ { "id": "BAALC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VHV1", "type": "external" } ], "mass": 15515.0, "length": 145, "protein_name": "Brain and acute leukemia cytoplasmic protein", "gene_name": "Baalc", "organism": "Mouse", "refseq_name": "brain and acute leukemia cytoplasmic protein isoform 1-6-8", "refseq_ac": [ { "id": "NP_542371", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_542371", "type": "external" } ], "gene_names_uniprotkb": "Baalc", "gene_names_refseq": "2810457D07Rik; Baalc", "protein_names_uniprotkb": "Brain and acute leukemia cytoplasmic protein", "protein_names_refseq": "brain and acute leukemia cytoplasmic protein isoform 1-6-8; brain and acute leukemia cytoplasmic protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:118452)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;11707601;15749074;21750661", "class_list": "", "function": "BAALC/Baalc is a marker of the mesodermal lineage, especially muscle., [RefSeq, PubMed]; May play a synaptic role at the postsynaptic lipid rafts possibly through interaction with CAMK2A., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A9JR49;Q8VBS8;Q9CYS9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0014069 postsynaptic density;GO:0045121 membrane raft", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8VHV1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91VR8-1", "uniprot_id": [ { "id": "BRK1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91VR8", "type": "external" } ], "mass": 8761.0, "length": 75, "protein_name": "Protein BRICK1", "gene_name": "Brk1", "organism": "Mouse", "refseq_name": "protein BRICK1", "refseq_ac": [ { "id": "NP_598698", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598698", "type": "external" } ], "gene_names_uniprotkb": "Brk1", "gene_names_refseq": "6720456B07Rik; Brk1", "protein_names_uniprotkb": "Protein BRICK1; BRK1", "protein_names_refseq": "probable protein BRICK1; protein BRICK1", "tax_id": 10090, "disease": "", "pathway": " (mmu:101314); (R-MMU-2029482); (R-MMU-4420097); (R-MMU-5663213); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013423)", "pathway_count": 7, "publication_count": 2, "publication_id_list": "20861187;27605705", "class_list": "", "function": "Data show that genetic ablation of Brk1 results in dramatic defects in embryo compaction and development, suggesting an essential role for this protein in actin dynamics., [RefSeq, PubMed]; Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex (By similarity). As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (PubMed:27605705)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TLB8", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0030027 lamellipodium;GO:0031209 SCAR complex", "go_biological_process": "GO:0008064 regulation of actin polymerization or depolymerization;GO:0001701 in utero embryonic development;GO:0007015 actin filament organization;GO:0008284 positive regulation of cell population proliferation;GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q91VR8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91Y44-1", "uniprot_id": [ { "id": "BRDT_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91Y44", "type": "external" } ], "mass": 107255.0, "length": 956, "protein_name": "Bromodomain testis-specific protein", "gene_name": "Brdt", "organism": "Mouse", "refseq_name": "bromodomain testis-specific protein isoform B", "refseq_ac": [ { "id": "NP_001073342", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073342", "type": "external" } ], "gene_names_uniprotkb": "Brdt; Fsrg3", "gene_names_refseq": "7420412D09Rik; Brd6; Brdt; Fsrg3", "protein_names_uniprotkb": "Bromodomain testis-specific protein; Bromodomain-containing female sterile homeotic-like protein; RING3-like protein", "protein_names_refseq": "RING3-like protein; bromodomain testis-specific protein isoform B; bromodomain testis-specific protein; bromodomain-containing female sterile homeotic-like protein; female sterile homeotic-related gene 3", "tax_id": 10090, "disease": "spermatogenic failure 21 (Disease Ontology:DOID:0070163); azoospermia (Disease Ontology:DOID:14227); oligospermia (Disease Ontology:DOID:14228)", "pathway": " (mmu:114642)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "12861021;15261828;17049203;17728347;19794495;21183079;22020252;22570411;22901802;22922464;25428506;27105113;27669760;32726616;33469999", "class_list": "", "function": "Genome-wide chromatin occupancy of BRDT and gene expression analysis suggest transcriptional partners and specific epigenetic landscapes that regulate gene expression during spermatogenesis., [RefSeq, PubMed]; Phylogenetic analyses show that the BRDT germ cell-specific orthology group clearly evolves faster than its ubiquitously expressed paralogs BRD2, BRD3, and BRD4, [RefSeq, PubMed]; Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis (PubMed:12861021, PubMed:19794495, PubMed:22901802, PubMed:22922464). Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time. In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA (PubMed:22901802, PubMed:32726616). Also recognizes and binds a subset of butyrylated histones: able to bind histone H4 butyrylated at 'Lys-8' (H4K8ac), while it is not able to bind H4 butyrylated at 'Lys-5' (H4K5ac) (PubMed:27105113). Also acts as a component of the splicing machinery in pachytene spermatocytes and round spermatids and participates in 3'-UTR truncation of specific mRNAs in post-meiotic spermatids (PubMed:22570411). Required for chromocenter organization, a structure comprised of peri-centromeric heterochromatin (PubMed:22020252)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The protein encoded by this gene belongs to the BET protein family. BET proteins have two N-terminal bromodomains and one C-terminal extraterminal domain (ET domain). BET proteins regulate chromatin reorganization via binding to acetylated histones. This gene is thought to play a role in the transcriptional regulation of spermatogenesis. Although referred to as testis-specific bromodomain (Brdt) protein, RT-PCR indicates that this gene is expressed in both mouse oocytes and testes. Alternative splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "G3X8Z8;Q59HJ4", "ec_number_list": [], "go_molecular_function": "GO:0042393 histone binding;GO:0140566 histone reader activity;GO:0140008 histone H4 reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0007283 spermatogenesis;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q91Y44-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R1W5-1", "uniprot_id": [ { "id": "CALRL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R1W5", "type": "external" } ], "mass": 53265.0, "length": 463, "protein_name": "Calcitonin gene-related peptide type 1 receptor", "gene_name": "Calcrl", "organism": "Mouse", "refseq_name": "calcitonin gene-related peptide type 1 receptor precursor", "refseq_ac": [ { "id": "NP_061252", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061252", "type": "external" } ], "gene_names_uniprotkb": "Calcrl; Crlr", "gene_names_refseq": "CRLR; Calcrl", "protein_names_uniprotkb": "Calcitonin gene-related peptide type 1 receptor; CGRP type 1 receptor; Calcitonin receptor-like receptor", "protein_names_refseq": "CGRP type 1 receptor; calcitonin gene-related peptide type 1 receptor precursor; calcitonin gene-related peptide type 1 receptor; calcitonin receptor-like receptor", "tax_id": 10090, "disease": "hereditary lymphedema (Disease Ontology:DOID:0050580); brain infarction (Disease Ontology:DOID:3454)", "pathway": " (mmu:54598); (R-MMU-418555); (R-MMU-419812); (R-MMU-9856530)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;10777702;11854283;12147211;21183079;25428506;30084848;30779550;34428180", "class_list": "", "function": "G protein-coupled receptor which specificity is determined by its interaction with receptor-activity-modifying proteins (RAMPs). Together with RAMP1, form the receptor complex for calcitonin-gene-related peptides CALCA/CGRP1 and CALCB/CGRP2. Together with RAMP2 or RAMP3, function as receptor complexes for adrenomedullin (ADM and ADM2). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway., [UniProtKB, UniProtKB]; Role in cell surface expression of CRLR/RAMP heterodimeric receptors, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9452, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q9QXH8;Q9WUP2", "ec_number_list": [], "go_molecular_function": "GO:0004948 calcitonin receptor activity;GO:0001605 adrenomedullin receptor activity;GO:0001635 calcitonin gene-related peptide receptor activity;GO:1990409 adrenomedullin binding", "go_cellular_component": "GO:0098992 neuronal dense core vesicle;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9R1W5-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61036-1", "uniprot_id": [ { "id": "PAK3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61036", "type": "external" } ], "mass": 62398.0, "length": 559, "protein_name": "Serine/threonine-protein kinase PAK 3", "gene_name": "Pak3", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase PAK 3 isoform C", "refseq_ac": [ { "id": "NP_001181977", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181977", "type": "external" } ], "gene_names_uniprotkb": "Pak3; Pak-3; Pakb; Stk4", "gene_names_refseq": "PAK-3; Pak3; Pak65alpha; Pak65beta; Stk4", "protein_names_uniprotkb": "Serine/threonine-protein kinase PAK 3; 2.7.11.1; Beta-PAK; CDC42/RAC effector kinase PAK-B; PAK-3; p21-activated kinase 3", "protein_names_refseq": "CDC42/RAC effector kinase PAK-B; beta-PAK; p21 protein (Cdc42/Rac)-activated kinase 3; p21-activated kinase 3; serine/threonine-protein kinase PAK 3 isoform C; serine/threonine-protein kinase PAK 3", "tax_id": 10090, "disease": "non-syndromic X-linked intellectual disability 30 (Disease Ontology:DOID:0112051)", "pathway": " (mmu:18481); (R-MMU-202433); (R-MMU-389359); (R-MMU-3928664); (R-MMU-399954); (R-MMU-5218920); (R-MMU-5621575); (R-MMU-5627123); (R-MMU-5687128); (R-MMU-9013149); (R-MMU-9013420)", "pathway_count": 11, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;10352232;10747784;12242269;12464619;15574732;15800193;16014725;17537723;20540949;21115725;21183079;21750661;25428506;25851601;34428180;36210013;38454080;38661167;7559398", "class_list": "", "function": "PAK3 activation promotes the tangential to radial migration switch of cortical interneurons by increasing leading process dynamics and disrupting cell polarity., [RefSeq, PubMed]; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity (PubMed:25851601). Acts as a downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (PubMed:15800193)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Tgif1-deficiency impairs cytoskeletal architecture in osteoblasts by activating PAK3 signaling. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O88645;Q8K1R5;Q8K1R6", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "1.6.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0017124 SH3 domain binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005829 cytosol;GO:0014069 postsynaptic density", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0006468 protein phosphorylation;GO:0007409 axonogenesis;GO:0016358 dendrite development;GO:0016477 cell migration", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q61036-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JK83-1", "uniprot_id": [ { "id": "PAR6B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JK83", "type": "external" } ], "mass": 41067.0, "length": 371, "protein_name": "Partitioning defective 6 homolog beta", "gene_name": "Pard6b", "organism": "Mouse", "refseq_name": "partitioning defective 6 homolog beta", "refseq_ac": [ { "id": "NP_067384", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067384", "type": "external" } ], "gene_names_uniprotkb": "Pard6b; Par6b", "gene_names_refseq": "Par6b; Pard6b", "protein_names_uniprotkb": "Partitioning defective 6 homolog beta; PAR-6 beta; PAR-6B", "protein_names_refseq": "PAR-6 beta; PAR-6B; par-6 (partitioning defective 6) homolog beta; partitioning defective 6 homolog beta; partitioning-defective protein 6, beta", "tax_id": 10090, "disease": "", "pathway": " (mmu:58220); (R-MMU-420029); (R-MMU-9013424)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10934474;11839275;12545177;12606577;15140881;21183079;25428506", "class_list": "", "function": "Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ANX8;Q8R3J8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0005938 cell cortex", "go_biological_process": "GO:0060341 regulation of cellular localization;GO:0051301 cell division;GO:0007098 centrosome cycle;GO:0007163 establishment or maintenance of cell polarity;GO:0065003 protein-containing complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9JK83-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "L7N287-1", "uniprot_id": [ { "id": "L7N287_MOUSE", "url": "https://www.uniprot.org/uniprot/L7N287", "type": "external" } ], "mass": 31431.0, "length": 267, "protein_name": "Predicted gene 8297", "gene_name": "Gm8297", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gm8297", "gene_names_refseq": "", "protein_names_uniprotkb": "Predicted gene 8297", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "L7N287-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D541-1", "uniprot_id": [ { "id": "CCDC7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D541", "type": "external" } ], "mass": 184939.0, "length": 1642, "protein_name": "Coiled-coil domain-containing protein 7A", "gene_name": "Ccdc7a", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 7A isoform 2", "refseq_ac": [ { "id": "NP_001183970", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001183970", "type": "external" } ], "gene_names_uniprotkb": "Ccdc7a; Biot2; Ccdc7", "gene_names_refseq": "100042659; 4930517G15Rik; 4930540C21Rik; Biot2; Ccdc7a; Ccdc7; Gm3952", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 7A; Protein BIOT2", "protein_names_refseq": "coiled-coil domain containing 7; coiled-coil domain-containing protein 7A isoform 2; coiled-coil domain-containing protein 7A; coiled-coil domain-containing protein 7; putative cancer/testis antigen; testis-specific antigen", "tax_id": 10090, "disease": "", "pathway": " (mmu:74703)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;19277478;19950598;21750661;25706396", "class_list": "", "function": "Biot2-L was highly expressed in adult testis, and its expression increased regularly during testis development., [RefSeq, PubMed]; Silencing Biot2 in CT26 cells by RNA interference can inhibit cell growth in vitro and in vivo., [RefSeq, PubMed]; The Biot2 transcript was detected only and strongly in the testis tissues and abundantly in five types of murine cancer cell line., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A1L1SS82;D3YY17", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9D541-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TVA9-1", "uniprot_id": [ { "id": "CC136_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TVA9", "type": "external" } ], "mass": 131930.0, "length": 1136, "protein_name": "Coiled-coil domain-containing protein 136", "gene_name": "Ccdc136", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 136 isoform 2", "refseq_ac": [ { "id": "NP_001188307", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001188307", "type": "external" } ], "gene_names_uniprotkb": "Ccdc136", "gene_names_refseq": "4921511K06Rik; Ccdc136", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 136", "protein_names_refseq": "coiled-coil domain-containing protein 136 isoform 2; coiled-coil domain-containing protein 136; taraco", "tax_id": 10090, "disease": "", "pathway": " (mmu:232664)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;27076447", "class_list": "", "function": "May play a role in acrosome formation in spermatogenesis and in fertilization., [UniProtKB, PubMed]; Study demonstrates the essential role of CCDC136-mediated acrosome formation in spermatogenesis and fertilization, which might also provide new insight into the genetic causes of human infertility., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q923E5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0002080 acrosomal membrane", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007338 single fertilization;GO:0001675 acrosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3TVA9-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q09LZ8-1", "uniprot_id": [ { "id": "CBPC6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q09LZ8", "type": "external" } ], "mass": 62210.0, "length": 540, "protein_name": "Cytosolic carboxypeptidase 6", "gene_name": "Agbl4", "organism": "Mouse", "refseq_name": "cytosolic carboxypeptidase 6 isoform 2", "refseq_ac": [ { "id": "NP_001041654", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041654", "type": "external" } ], "gene_names_uniprotkb": "Agbl4; Ccp6", "gene_names_refseq": "4930578N11Rik; 4931433A01Rik; Agbl4", "protein_names_uniprotkb": "Cytosolic carboxypeptidase 6; 3.4.17.-; 3.4.17.24; ATP/GTP-binding protein-like 4; Protein deglutamylase CCP6", "protein_names_refseq": "cytosolic carboxypeptidase 6 isoform 2; cytosolic carboxypeptidase 6; protein deglutamylase CCP6", "tax_id": 10090, "disease": "", "pathway": " (mmu:78933)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17244818;21074048;21750661;25103237;25332286;26829768;29593216", "class_list": "", "function": "Metallocarboxypeptidase that mediates protein deglutamylation of tubulin and non-tubulin target proteins (PubMed:21074048, PubMed:25103237, PubMed:26829768, PubMed:29593216). Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of tubulin protein (PubMed:21074048, PubMed:25103237). Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate (PubMed:25103237). Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of non-tubulin proteins such as MYLK (PubMed:21074048). Mediates the deglutamylation of nucleotidyltransferase CGAS, leading to CGAS antiviral defense response activation (PubMed:26829768). Involved in KLF4 deglutamylation which promotes KLF4 proteasome-mediated degradation, thereby negatively regulating cell pluripotency maintenance and embryogenesis (PubMed:29593216)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Study shows that Mad2 is a novel substrate for CCP6 in megakaryocytes; Mad2 polyglutamylation plays a crucial role in the regulation of megakaryopoiesis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A979;A6PWC5;A6PWC6;Q09LZ9", "ec_number_list": [ { "id": "3.4.17.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.-", "type": "external" }, { "id": "3.4.17.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.24", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004181 metallocarboxypeptidase activity;GO:0015631 tubulin binding;GO:0008237 metallopeptidase activity;GO:0004180 carboxypeptidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0015630 microtubule cytoskeleton;GO:0005814 centriole", "go_biological_process": "GO:0006508 proteolysis;GO:0008285 negative regulation of cell population proliferation;GO:0051607 defense response to virus;GO:0021954 central nervous system neuron development;GO:0035608 protein deglutamylation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q09LZ8-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PYB3-1", "uniprot_id": [ { "id": "E9PYB3_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PYB3", "type": "external" } ], "mass": 35239.0, "length": 312, "protein_name": "Olfactory receptor", "gene_name": "Or52j3", "organism": "Mouse", "refseq_name": "olfactory receptor 592", "refseq_ac": [ { "id": "NP_997439", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997439", "type": "external" } ], "gene_names_uniprotkb": "Or52j3; Olfr592", "gene_names_refseq": "MOR0-3P; MOR32-13; Olfr1525-ps1; Olfr592; Or52j3", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 1525, pseudogene 1; olfactory receptor 592; olfactory receptor MOR0-3P", "tax_id": 10090, "disease": "", "pathway": " (mmu:404317)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Odorant receptor., [UniProtKB, UniProtKB, UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9PYB3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CE72-1", "uniprot_id": [ { "id": "CPLN1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CE72", "type": "external" } ], "mass": 358550.0, "length": 3214, "protein_name": "Ciliogenesis and planar polarity effector 1", "gene_name": "Cplane1", "organism": "Mouse", "refseq_name": "ciliogenesis and planar polarity effector 1", "refseq_ac": [ { "id": "NP_001156378", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156378", "type": "external" } ], "gene_names_uniprotkb": "Cplane1; 2410089E03Rik; Jbts17", "gene_names_refseq": "2410089E03Rik; 4732468D17Rik; Cplane1; Hug; Jbts17; b2b012Clo", "protein_names_uniprotkb": "Ciliogenesis and planar polarity effector 1; Protein C5orf42 homolog; Protein JBTS17", "protein_names_refseq": "ciliogenesis and planar polarity effector 1; protein C5orf42 homolog; protein JBTS17; transmembrane protein ENSP00000382582 homolog", "tax_id": 10090, "disease": "Joubert syndrome with orofaciodigital defect (Disease Ontology:DOID:0060376); Joubert syndrome 17 (Disease Ontology:DOID:0110986)", "pathway": " (mmu:73692)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21750661;25428506;25877302;27158779;31219806;34428180;39927985", "class_list": "", "function": "Involved in ciliogenesis. Involved in the establishment of cell polarity required for directional cell migration (PubMed:25877302). Proposed to act in association with the CPLANE (ciliogenesis and planar polarity effectors) complex. Involved in recruitment of peripheral IFT-A proteins to basal bodies (PubMed:27158779)., [UniProtKB, PubMed, PubMed]; JBTS17 is a cilia transition zone component that acts upstream of other Joubert syndrome associated transition zone proteins NPHP1 and CEP290, indicating its importance in the pathogenesis of Joubert syndrome., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "E9QL36;Q3UXY6;Q6PEE0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0035869 ciliary transition zone", "go_biological_process": "GO:0007507 heart development;GO:0001822 kidney development;GO:0060271 cilium assembly;GO:0003281 ventricular septum development;GO:0060021 roof of mouth development", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8CE72-1", "record_type": "protein", "filter_code": "0000000.1000111.001000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1X0-1", "uniprot_id": [ { "id": "CCL27_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z1X0", "type": "external" } ], "mass": 13464.0, "length": 120, "protein_name": "C-C motif chemokine 27", "gene_name": "Ccl27a; Ccl27", "organism": "Mouse", "refseq_name": "C-C motif chemokine 27 isoform 2 precursor", "refseq_ac": [ { "id": "NP_035466", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035466", "type": "external" } ], "gene_names_uniprotkb": "Ccl27a; Ccl27; Ilc; Scya27", "gene_names_refseq": "ALP; CTACK; CTAK; Ccl27a; Ccl27; ESkine; ILC; PESKY; Scya27a; Scya27", "protein_names_uniprotkb": "C-C motif chemokine 27; ALP; CC chemokine ILC; CTACK; Cutaneous T-cell-attracting chemokine; ESkine; IL-11 R-alpha-locus chemokine; Skinkine; Small-inducible cytokine A27; mILC", "protein_names_refseq": "C-C motif chemokine 27 isoform 2 precursor; C-C motif chemokine 27; CC chemokine ILC; IL-11 R-alpha-locus chemokine; chemokine (C-C motif) ligand 27A; cutaneous T-cell-attracting chemokine; skinkine; skinskine; small inducible cytokine A27a", "tax_id": 10090, "disease": "COVID-19 (Disease Ontology:DOID:0080600); asthma (Disease Ontology:DOID:2841); atopic dermatitis (Disease Ontology:DOID:3310)", "pathway": " (mmu:100039863); (mmu:100040048); (mmu:20301); (R-MMU-380108); (R-MMU-418594)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "10329455;10556532;10559234;10588729;12133963;21750661;25428506;27930971", "class_list": "", "function": "Chemotactic factor that attracts skin-associated memory T-lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. May play a role in cell migration during embryogenesis. Nuclear forms may facilitate cellular migration by inducing cytoskeletal relaxation. Binds to CCR10., [UniProtKB]; This study shows that losartan and dexamethasone may suppress inflammatory responses in IgA nephropathy by inhibiting CCL27 expression in Th22 cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3KNL1;Q9DAU6;Q9DAZ4", "ec_number_list": [], "go_molecular_function": "GO:0008009 chemokine activity;GO:0045236 CXCR chemokine receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus", "go_biological_process": "GO:0006954 inflammatory response;GO:0010820 positive regulation of T cell chemotaxis;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0071222 cellular response to lipopolysaccharide;GO:0030593 neutrophil chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9Z1X0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91XV3-1", "uniprot_id": [ { "id": "BASP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91XV3", "type": "external" } ], "mass": 22087.0, "length": 226, "protein_name": "Brain acid soluble protein 1", "gene_name": "Basp1", "organism": "Mouse", "refseq_name": "brain acid soluble protein 1", "refseq_ac": [ { "id": "NP_081671", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081671", "type": "external" } ], "gene_names_uniprotkb": "Basp1; Nap22", "gene_names_refseq": "2610024P12Rik; Basp1; CAP-23; CAP23; Ckap3; NAP-22; NAP22", "protein_names_uniprotkb": "Brain acid soluble protein 1; 22 kDa neuronal tissue-enriched acidic protein; Neuronal axonal membrane protein NAP-22", "protein_names_refseq": "22 kDa neuronal tissue-enriched acidic protein; brain acid soluble protein 1; cytoskeleton associated protein 3; neuronal axonal membrane protein NAP-22", "tax_id": 10090, "disease": "", "pathway": " (mmu:70350); (R-MMU-9035034)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "17114649;18250455;19144319;21183079;21750661;22517741;26495903;28011936;32848054;33725478;35822049;36756695;37207971;37505219;37619639", "class_list": "", "function": "BASP1 down-regulates RANKL-induced osteoclastogenesis., [RefSeq, PubMed]; BASP1 knockdown suppresses chondrocyte apoptosis and extracellular matrix degradation in vivo and in vitro: A possible therapeutic approach for osteoarthritis., [RefSeq, PubMed]; BASP1 promotes high glucose-induced endothelial apoptosis in diabetes via activation of EGFR signaling., [RefSeq, PubMed]; Myeloid-specific ablation of Basp1 ameliorates diet-induced NASH in mice by attenuating pro-inflammatory signaling., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0019904 protein domain specific binding;GO:0003714 transcription corepressor activity;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016607 nuclear speck;GO:0030054 cell junction", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0045892 negative regulation of DNA-templated transcription;GO:0097435 supramolecular fiber organization;GO:0072112 podocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q91XV3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BS90-1", "uniprot_id": [ { "id": "BORA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BS90", "type": "external" } ], "mass": 57038.0, "length": 525, "protein_name": "Protein aurora borealis", "gene_name": "Bora", "organism": "Mouse", "refseq_name": "protein aurora borealis", "refseq_ac": [ { "id": "NP_780474", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780474", "type": "external" } ], "gene_names_uniprotkb": "Bora", "gene_names_refseq": "6720463M24Rik; Bora", "protein_names_uniprotkb": "Protein aurora borealis", "protein_names_refseq": "aurora borealis; protein aurora borealis", "tax_id": 10090, "disease": "", "pathway": " (mmu:77744); (R-MMU-2565942); (R-MMU-69273)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "21183079;21750661;23610072;24129315;32782141", "class_list": "", "function": "Required for the activation of AURKA at the onset of mitosis., [UniProtKB]; Studied the expression, localization, and function of Bora during mouse oocyte meiosis. Findings indicated that Bora acts as a critical regulator of Aurora A and Plk1, and is involved in microtubule organization during oocyte meiosis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJH7;Q3UWZ8;Q80WQ5;Q8C8E9", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0072687 meiotic spindle", "go_biological_process": "GO:0051301 cell division;GO:0032880 regulation of protein localization;GO:0060236 regulation of mitotic spindle organization;GO:0007088 regulation of mitotic nuclear division", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BS90-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P68404-1", "uniprot_id": [ { "id": "KPCB_MOUSE", "url": "https://www.uniprot.org/uniprot/P68404", "type": "external" } ], "mass": 76751.0, "length": 671, "protein_name": "Protein kinase C beta type", "gene_name": "Prkcb", "organism": "Mouse", "refseq_name": "protein kinase C beta type isoform 2", "refseq_ac": [ { "id": "NP_001303601", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001303601", "type": "external" } ], "gene_names_uniprotkb": "Prkcb; Pkcb; Prkcb1", "gene_names_refseq": "PKC-Beta; PKC-B; Pkcb; Prkcb1; Prkcb2; Prkcb", "protein_names_uniprotkb": "Protein kinase C beta type; 2.7.11.13; PKC-B; PKC-beta", "protein_names_refseq": "protein kinase C beta type isoform 2; protein kinase C beta type; protein kinase C beta-II; protein kinase C, beta 1", "tax_id": 10090, "disease": "silicosis (Disease Ontology:DOID:10325); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); dilated cardiomyopathy (Disease Ontology:DOID:12930); alcohol use disorder (Disease Ontology:DOID:1574); status epilepticus (Disease Ontology:DOID:1824); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hyperglycemia (Disease Ontology:DOID:4195); congestive heart failure (Disease Ontology:DOID:6000); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:18751); (R-MMU-114516); (R-MMU-1169091); (R-MMU-416993); (R-MMU-4419969); (R-MMU-5099900); (R-MMU-5218921); (R-MMU-5668599); (R-MMU-76005)", "pathway_count": 9, "publication_count": 26, "publication_id_list": "10.1101/2023.09.13.557529;10499500;11805327;12070292;12118249;12881490;16301747;16356855;16452087;16505232;17114649;17272725;17962198;21183079;2402470;26495903;30084848;33300544;33850054;34428180;34622807;35821297;36210013;36239013;37315788;8670417", "class_list": "", "function": "Acts as an activator of ferroptosis by mediating phosphorylation and activation of ACSL4. Also stimulates ferroptosis propagation by catalyzing phosphorylation of FOXK1., [UniProtKB, UniProtKB]; Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A. In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. Participates in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Phosphorylates SLC2A1/GLUT1, promoting glucose uptake by SLC2A1/GLUT1. Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription (By similarity). Phosphorylates KLHL3 in response to angiotensin II signaling, decreasing the interaction between KLHL3 and WNK4 (By similarity). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Hepatic protein kinase Cbeta deficiency mitigates late-onset obesity., [RefSeq, PubMed]; Loss of RPTPgamma primes breast tissue for acid extrusion, promotes malignant transformation and results in early tumour recurrence and shortened survival., [RefSeq, PubMed]; Protein kinase C beta relieves autism-like behavior in EN2 knockout mice via upregulation of the FTO/PGC-1alpha/UCP1 axis., [RefSeq, PubMed]; Role of hepatic PKCbeta in nutritional regulation of hepatic glycogen synthesis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 10, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0JNZ5;F2Z441;P04410;P04411", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.1.91", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.91", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0044305 calyx of Held;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0010829 negative regulation of D-glucose transmembrane transport;GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006468 protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "P68404-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DFW0-1", "uniprot_id": [ { "id": "CI072_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6DFW0", "type": "external" } ], "mass": 54278.0, "length": 481, "protein_name": "Guanine nucleotide exchange factor C9orf72 homolog", "gene_name": "C9orf72", "organism": "Mouse", "refseq_name": "guanine nucleotide exchange factor C9orf72 homolog isoform 1", "refseq_ac": [ { "id": "NP_001074812", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074812", "type": "external" } ], "gene_names_uniprotkb": "C9orf72; 3110043O21Rik; Dennd9; Dennl72", "gene_names_refseq": "3110043O21Rik; C9orf72; Dennd9", "protein_names_uniprotkb": "Guanine nucleotide exchange factor C9orf72 homolog", "protein_names_refseq": "guanine nucleotide exchange C9orf72 homolog; guanine nucleotide exchange factor C9orf72 homolog isoform 1; guanine nucleotide exchange factor C9orf72 homolog; protein C9orf72 homolog", "tax_id": 10090, "disease": "C9orf72 frontotemporal dementia and/or amyotrophic lateral sclerosis (Disease Ontology:DOID:0060213); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); autoimmune disease (Disease Ontology:DOID:417)", "pathway": " (mmu:73205)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "21750661;24549040;25428506;26044557;26408000;26989253;27193190;27412785;27476503;27617292;27723745;27875531;30366907;31651360;34428180;36210013;38684907;38942112", "class_list": "", "function": "Acts as a guanine-nucleotide releasing factor (GEF) for Rab GTPases by promoting the conversion of inactive RAB-GDP to the active form RAB-GTP (PubMed:27193190, PubMed:27617292). Acts as a GEF for RAB39A which enables HOPS-mediated autophagosome-lysosome membrane tethering and fusion in mammalian autophagy (By similarity). Component of the C9orf72-SMCR8 complex where both subunits display GEF activity and that regulates autophagy (PubMed:27193190, PubMed:27617292). As part of the C9orf72-SMCR8-WDR41 (CSW) complex, functions as GEF for RAB8A, and RAB39B, thereby promoting autophagosome maturation (By similarity). As part of the C9orf72-SMCR8 complex, also functions as GTPase activating protein (GAP) for RAB8A and RAB11A in vitro (By similarity). The C9orf72-SMCR8 complex also acts as a regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and modulating its protein kinase activity (PubMed:27193190, PubMed:27617292). Promotes initiation of autophagy by regulating the RAB1A-dependent trafficking of the ULK1/ATG1 kinase complex to the phagophore which leads to autophagosome formation (By similarity). Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates (PubMed:27875531). Plays a role in endosomal trafficking (PubMed:26989253). May be involved in regulating the maturation of phagosomes to lysosomes (PubMed:26989253). Promotes the lysosomal localization and lysosome-mediated degradation of CARM1 which leads to inhibition of starvation-induced lipid metabolism (PubMed:30366907). Regulates actin dynamics in motor neurons by inhibiting the GTP-binding activity of ARF6, leading to ARF6 inactivation (PubMed:27723745). This reduces the activity of the LIMK1 and LIMK2 kinases which are responsible for phosphorylation and inactivation of CFL1/cofilin, leading to cofilin activation (PubMed:27723745). Positively regulates axon extension and axon growth cone size in spinal motor neurons (PubMed:27723745). Required for SMCR8 protein expression and localization at pre- and post-synaptic compartments in the forebrain, also regulates protein abundance of RAB3A and GRIA1/GLUR1 in post-synaptic compartments in the forebrain and hippocampus (PubMed:31651360). Plays a role within the hematopoietic system in restricting inflammation and the development of autoimmunity (PubMed:27412785)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Glucose hypometabolism prompts RAN translation and exacerbates C9orf72-related ALS/FTD phenotypes., [RefSeq, PubMed]; MiR-142-3p alleviates neuronal apoptosis in Parkinson's disease via negatively regulating C9orf72., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6PWW3;Q3TJP2;Q3U3D8", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005768 endosome", "go_biological_process": "GO:0006897 endocytosis;GO:0010506 regulation of autophagy;GO:0001933 negative regulation of protein phosphorylation;GO:0032880 regulation of protein localization;GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q6DFW0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54991-1", "uniprot_id": [ { "id": "CNTP1_MOUSE", "url": "https://www.uniprot.org/uniprot/O54991", "type": "external" } ], "mass": 156312.0, "length": 1385, "protein_name": "Contactin-associated protein 1", "gene_name": "Cntnap1", "organism": "Mouse", "refseq_name": "contactin-associated protein 1 precursor", "refseq_ac": [ { "id": "NP_058062", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058062", "type": "external" } ], "gene_names_uniprotkb": "Cntnap1; Nrxn4", "gene_names_refseq": "Caspr; Cntnap1; NCP1; Nrxn4; p190; shm", "protein_names_uniprotkb": "Contactin-associated protein 1; Caspr1; Caspr; MHDNIV; NCP1; Neurexin IV; Neurexin-4; Paranodin", "protein_names_refseq": "MHDNIV; caspr1; contactin-associated protein 1 precursor; contactin-associated protein 1; neurexin 4 (contactin associated protein); neurexin IV; neurexin-4; paranodin", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal recessive intellectual developmental disorder (Disease Ontology:DOID:0060308); lethal congenital contracture syndrome (Disease Ontology:DOID:0060558)", "pathway": " (mmu:53321)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;11395000;11512672;17114649;21183079;21952136;25378149;30084848;30899004;33300544;37862170;40885482", "class_list": "", "function": "Mouse models of human CNTNAP1-associated congenital hypomyelinating neuropathy and genetic restoration of murine neurological deficits., [RefSeq, PubMed]; Required, with CNTNAP2, for radial and longitudinal organization of myelinated axons (PubMed:25378149). Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the paranodal region of the axo-glial junction. In association with contactin involved in the signaling between axons and myelinating glial cells (PubMed:11395000, PubMed:25378149)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 13, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 13, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 13, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 13, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 19, "disease_count": 3, "glyco_site_count": 21, "binding_glycan_count": 0, "secondary_ac_list": "A2A4K6", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0030424 axon;GO:0043209 myelin sheath;GO:0045202 synapse", "go_biological_process": "GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0007399 nervous system development;GO:0007409 axonogenesis;GO:0022010 central nervous system myelination", "synthesized_glycan_count": 0, "hit_score": 4.8, "record_id": "O54991-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TTA7-1", "uniprot_id": [ { "id": "CBLB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TTA7", "type": "external" } ], "mass": 109092.0, "length": 982, "protein_name": "E3 ubiquitin-protein ligase CBL-B", "gene_name": "Cblb", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase CBL-B", "refseq_ac": [ { "id": "NP_001028410", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028410", "type": "external" } ], "gene_names_uniprotkb": "Cblb", "gene_names_refseq": "Cbl-b; Cblb", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase CBL-B; 2.3.2.27; Casitas B-lineage lymphoma proto-oncogene b; RING-type E3 ubiquitin transferase CBL-B; SH3-binding protein CBL-B; Signal transduction protein CBL-B", "protein_names_refseq": "Casitas B-lineage lymphoma b; E3 ubiquitin-protein ligase CBL-B; RING-type E3 ubiquitin transferase CBL-B; SH3-binding protein CBL-B; casitas B-lineage lymphoma proto-oncogene b; signal transduction protein CBL-B", "tax_id": 10090, "disease": "infantile onset multisystem autoimmune disease 3 (Disease Ontology:DOID:0061162); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); stomach carcinoma (Disease Ontology:DOID:5517); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:208650); (R-MMU-983168)", "pathway_count": 2, "publication_count": 22, "publication_id_list": "10.1101/2023.09.13.557529;10646608;10646609;11070165;11526404;11826757;12193687;12771181;12842890;15308098;15592455;20173027;21183079;26495903;29109121;29237719;31219806;34428180;36006710;38504977;38761804;39004726", "class_list": "", "function": "Deficiency of CBL and CBLB ubiquitin ligases leads to hyper T follicular helper cell responses and lupus by reducing BCL6 degradation., [RefSeq, PubMed]; E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome (PubMed:10646608, PubMed:10646609, PubMed:11070165). Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways (PubMed:10646608, PubMed:10646609, PubMed:11070165). In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production (PubMed:10646608, PubMed:10646609, PubMed:11070165). Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation (PubMed:11526404). In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy (PubMed:15308098). Involved in LAG3-mediated inhibition of TCR signaling: following ligand-binding to LAG3, catalyzes 'Lys-63'-linked ubiquitination of LAG3, unleashing the LAG3 C-terminus from the membrane, and initiating a signaling that prevents TCR activation (By similarity). In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation (PubMed:12771181). Slightly promotes SRC ubiquitination (By similarity). May be involved in EGFR ubiquitination and internalization (By similarity). May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3 (By similarity). In association with CBL, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (PubMed:29237719)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Exploring the role of CBLB in acute myocardial infarction: transcriptomic, microbiomic, and metabolomic analyses. Publication Status: Online-Only, [RefSeq, PubMed]; Novel E3 ubiquitin-protein ligase; role in regulation of immune response - review Review article, [RefSeq, PubMed]; T cell specific deletion of Casitas B lineage lymphoma-b reduces atherosclerosis, but increases plaque T cell infiltration and systemic T cell activation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QMY2", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0008270 zinc ion binding;GO:0019901 protein kinase binding;GO:0005509 calcium ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0045121 membrane raft", "go_biological_process": "GO:0006955 immune response;GO:0007165 signal transduction;GO:0030155 regulation of cell adhesion;GO:0035556 intracellular signal transduction;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q3TTA7-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80VC9-1", "uniprot_id": [ { "id": "CAMP3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80VC9", "type": "external" } ], "mass": 135175.0, "length": 1252, "protein_name": "Calmodulin-regulated spectrin-associated protein 3", "gene_name": "Camsap3", "organism": "Mouse", "refseq_name": "calmodulin-regulated spectrin-associated protein 3 isoform 3", "refseq_ac": [ { "id": "NP_001334040", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334040", "type": "external" } ], "gene_names_uniprotkb": "Camsap3; Kiaa1543", "gene_names_refseq": "2310057J16Rik; Camsap3; Kiaa1543; Nezha", "protein_names_uniprotkb": "Calmodulin-regulated spectrin-associated protein 3; Marshalin; Protein Nezha", "protein_names_refseq": "calmodulin-regulated spectrin-associated protein 3 isoform 3; calmodulin-regulated spectrin-associated protein 3; marshalin; protein Nezha", "tax_id": 10090, "disease": "", "pathway": " (mmu:69697)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;22645316;23169647;24244856;24706919;26715742;27349180;28860385;30787442;32482850;34428180;36852467;37013686", "class_list": "", "function": "CAMSAP2 and -3 work together to maintain noncentrosomal microtubules in epithelial cells, suppressing the microtubule-organizing ability of the centrosome., [RefSeq, PubMed]; Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24706919, PubMed:26715742). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24706919). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (By similarity). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:26715742). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (PubMed:28860385). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (By similarity). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (By similarity). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (By similarity). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (By similarity). Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (PubMed:32482850)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Paracingulin recruits CAMSAP3 to tight junctions and regulates microtubule and polarized epithelial cell organization., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 17, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "E9Q5B0;Q5DTW9;Q8BUZ0;U5LGR7;U5LGS1;U5LGS5;U5LGT0;U5LHT8;U5LHU4;U5LHW1;U5LHW4;U5LHW9;U5LK15;U5LK19;U5LK24;U5LK70;U5LK74;U5LK79", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0051015 actin filament binding;GO:0030507 spectrin binding;GO:0051011 microtubule minus-end binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0031514 motile cilium;GO:0015630 microtubule cytoskeleton;GO:0005930 axoneme", "go_biological_process": "GO:0051893 regulation of focal adhesion assembly;GO:0009792 embryo development ending in birth or egg hatching;GO:0098840 protein transport along microtubule;GO:0001701 in utero embryonic development;GO:0031175 neuron projection development", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q80VC9-1", "record_type": "protein", "filter_code": "0000000.1100101.010000.000000000000100000.1100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BSP2-1", "uniprot_id": [ { "id": "CNDH2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BSP2", "type": "external" } ], "mass": 68945.0, "length": 607, "protein_name": "Condensin-2 complex subunit H2", "gene_name": "Ncaph2", "organism": "Mouse", "refseq_name": "condensin-2 complex subunit H2 isoform a", "refseq_ac": [ { "id": "NP_001108604", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108604", "type": "external" } ], "gene_names_uniprotkb": "Ncaph2; D15Ertd785e", "gene_names_refseq": "Ncaph2", "protein_names_uniprotkb": "Condensin-2 complex subunit H2; Kleisin-beta; Non-SMC condensin II complex subunit H2", "protein_names_refseq": "condensin-2 complex subunit H2 isoform a; condensin-2 complex subunit H2; kleisin beta", "tax_id": 10090, "disease": "", "pathway": " (mmu:52683); (R-MMU-2299718)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "17525332;17640884;19892989;21183079;21750661;22333158;25428506;25605945;27737959;28528544;30084848;30779550;31219806;31599954;34428180;39627609", "class_list": "", "function": "Define a unique lineage-specific requirement for kleisin beta in mammalian T cell differentiation, [RefSeq, PubMed]; Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (By similarity). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). Seems to have lineage-specific role in T-cell development (By similarity)., [UniProtKB, UniProtKB, PubMed]; This gene encodes a component of the condensin-2 complex. The encoded protein may regulate the structure of mitotic chromosomes. Loss of function of this gene disrupts T-cell development. There are two pseudogenes for this gene on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]., [RefSeq]; We confirm that Ncaph2 can generate three different N-termini, all encoded by exon 1, one of which is translated from an alternative reading frame., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TNI4;Q8C2N3;Q8C3K9;Q8C4X8;Q8CAZ3;Q99L21;Q9CT99", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0030054 cell junction;GO:0045171 intercellular bridge", "go_biological_process": "GO:1905820 positive regulation of chromosome separation;GO:0051984 positive regulation of chromosome segregation;GO:0021987 cerebral cortex development;GO:0007076 mitotic chromosome condensation;GO:0007143 female meiotic nuclear division", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q8BSP2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R149-1", "uniprot_id": [ { "id": "BUD13_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R149", "type": "external" } ], "mass": 72139.0, "length": 637, "protein_name": "BUD13 homolog", "gene_name": "Bud13", "organism": "Mouse", "refseq_name": "BUD13 homolog", "refseq_ac": [ { "id": "NP_666112", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666112", "type": "external" } ], "gene_names_uniprotkb": "Bud13", "gene_names_refseq": "Bud13; D030060M11Rik", "protein_names_uniprotkb": "BUD13 homolog", "protein_names_refseq": "BUD13 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:215051); (R-MMU-72163)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "17242355;21183079;21750661;22872234;30639243;30779550;31219806;34428180;36463205;38053379", "class_list": "", "function": "BUD13 is a protein that has the ability to increase splicing of the Irf7 intron. BUD13 depletion compromises type I interferon response by countering intron retention in Irf7., [RefSeq, PubMed]; Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity)., [UniProtKB, UniProtKB]; RNASEH1-AS1 induced by H3K27ac stabilizes ANXA2 mRNA to promote the progression of colorectal cancer through recruiting BUD13., [RefSeq, PubMed]; The mechanism of BUD13 m6A methylation mediated MBNL1-phosphorylation by CDK12 regulating the vasculogenic mimicry in glioblastoma cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 31, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BQC0;Q8CB03", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005681 spliceosomal complex;GO:0071006 U2-type catalytic step 1 spliceosome;GO:0005684 U2-type spliceosomal complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8R149-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZE2-1", "uniprot_id": [ { "id": "CLNK_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QZE2", "type": "external" } ], "mass": 49492.0, "length": 435, "protein_name": "Cytokine-dependent hematopoietic cell linker", "gene_name": "Clnk", "organism": "Mouse", "refseq_name": "cytokine-dependent hematopoietic cell linker", "refseq_ac": [ { "id": "NP_038776", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038776", "type": "external" } ], "gene_names_uniprotkb": "Clnk; Mist", "gene_names_refseq": "Clnk; MIST", "protein_names_uniprotkb": "Cytokine-dependent hematopoietic cell linker; Mast cell immunoreceptor signal transducer", "protein_names_refseq": "cytokine-dependent hematopoietic cell linker; mast cell immunoreceptor signal transducer", "tax_id": 10090, "disease": "", "pathway": " (mmu:27278)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10562326;10744659;11463797;11509653;12681493;15199160;15358227;16439675;17947660;26009488;34428180;36210013", "class_list": "", "function": "An adapter protein which plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation (PubMed:10562326, PubMed:10744659, PubMed:11509653, PubMed:12681493). Together with FGR, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production (PubMed:15199160, PubMed:16439675). Acts as a positive regulator of both T-cell receptor and natural killer T (NKT) cell receptor signaling in CD4-positive NKT cells (PubMed:16439675). Together with MAP4K1, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (PubMed:11509653). May be involved in tumor necrosis factor induced cell death by promoting reactive oxidative species generation, and MLKL oligomerization, ultimately leading to necrosis (PubMed:26009488). Involved in phosphorylation of LAT (PubMed:11463797). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (PubMed:12681493)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Clnk is dispensable for normal differentiation and function of T cells, mast cells, and NK cells. Hence, unlike its relatives, Clnk is not essential for normal immune functions, [RefSeq, PubMed]; Clnk is required for TNF-alpha -induced cell death in L929 cells., [RefSeq, PubMed]; Interaction of MIST with Fgr, mediated by the C-terminal proline-rich region of MIST and the SH3 domain of Fgr, was required for the suppression of NK-cell receptor-induced IFN-gamma production, [RefSeq, PubMed]; STAT5 is involved in cytokine-mediated up-regulation of MIST gene expression, in collaboration with other lineage-specific transcription factors that promote basal MIST expression in mast cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C479;Q9JMJ3", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0042629 mast cell granule;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006955 immune response;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0035556 intracellular signal transduction;GO:0043303 mast cell degranulation;GO:0002729 positive regulation of natural killer cell cytokine production", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9QZE2-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C5W0-1", "uniprot_id": [ { "id": "CLMN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C5W0", "type": "external" } ], "mass": 117227.0, "length": 1052, "protein_name": "Calmin", "gene_name": "Clmn", "organism": "Mouse", "refseq_name": "calmin isoform b", "refseq_ac": [ { "id": "NP_001035772", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035772", "type": "external" } ], "gene_names_uniprotkb": "Clmn", "gene_names_refseq": "9330188N17Rik; Clmn; mKIAA1188", "protein_names_uniprotkb": "Calmin; Calponin-like transmembrane domain protein", "protein_names_refseq": "calmin isoform b; calponin-like transmembrane domain protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:94040)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;11386753;12670712;16452087;17242355;21183079;21750661;34428180", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9718, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q91V71;Q91XT7;Q91XT8;Q91XU9", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0005640 nuclear outer membrane;GO:0034993 meiotic nuclear membrane microtubule tethering complex", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0031175 neuron projection development;GO:0007097 nuclear migration", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8C5W0-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23198-1", "uniprot_id": [ { "id": "CBX3_MOUSE", "url": "https://www.uniprot.org/uniprot/P23198", "type": "external" } ], "mass": 20855.0, "length": 183, "protein_name": "Chromobox protein homolog 3", "gene_name": "Cbx3", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cbx3", "gene_names_refseq": "", "protein_names_uniprotkb": "Chromobox protein homolog 3; HP1 gamma; Heterochromatin protein 1 homolog gamma; M32; Modifier 2 protein", "protein_names_refseq": "", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (R-MMU-8953750); (R-MMU-9940465)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "15145825;1708124;18630941;19144319;21183079;21540332;21750661;22645316;23806337;24413057;25153642;28135057;28528544;34428180;35984892;36288343;8751383;8978696", "class_list": "", "function": "Component of heterochromatin, which recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression (By similarity). Also recognizes and binds histone H1.4 methylated at 'Lys-26' (H1.4K26me) (By similarity). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins (By similarity). Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1 (PubMed:24413057). Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs) (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q921C4", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0019899 enzyme binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005819 spindle;GO:0016604 nuclear body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0006974 DNA damage response;GO:0048511 rhythmic process;GO:0010467 gene expression", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P23198-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99J95-1", "uniprot_id": [ { "id": "CDK9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99J95", "type": "external" } ], "mass": 42762.0, "length": 372, "protein_name": "Cyclin-dependent kinase 9", "gene_name": "Cdk9", "organism": "Mouse", "refseq_name": "cyclin-dependent kinase 9", "refseq_ac": [ { "id": "NP_570930", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_570930", "type": "external" } ], "gene_names_uniprotkb": "Cdk9", "gene_names_refseq": "Cdk9; PITALRE", "protein_names_uniprotkb": "Cyclin-dependent kinase 9; 2.7.11.22; 2.7.11.23; Cell division protein kinase 9", "protein_names_refseq": "cell division protein kinase 9; cyclin dependent kinase 9 (CDC2-related kinase); cyclin-dependent kinase 9", "tax_id": 10090, "disease": "renal carcinoma (Disease Ontology:DOID:4451); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (mmu:107951); (R-MMU-112382); (R-MMU-2173796); (R-MMU-674695); (R-MMU-6796648); (R-MMU-6807505); (R-MMU-75955); (R-MMU-9018519)", "pathway_count": 8, "publication_count": 9, "publication_id_list": "10797576;12037670;12115727;21750661;22767893;27292648;34428180;39235466;9766517", "class_list": "", "function": "CDK9 has the intrinsic property to shuttle between nucleus and cytoplasm, and enhanced expression of cyclin T1 promotes its nuclear localization., [RefSeq, PubMed]; Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP. This complex is inactive when in the 7SK snRNP complex form. Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR and the negative elongation factors DSIF and NELFE. Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors (e.g. TNF-inducible RELA/p65 activation and IL-6-inducible STAT3 signaling). Promotes RNA synthesis in genetic programs for cell growth, differentiation and viral pathogenesis. P-TEFb is also involved in cotranscriptional histone modification, mRNA processing and mRNA export. Modulates a complex network of chromatin modifications including histone H2B monoubiquitination (H2Bub1), H3 lysine 4 trimethylation (H3K4me3) and H3K36me3; integrates phosphorylation during transcription with chromatin modifications to control co-transcriptional histone mRNA processing. Also catalyzes phosphorylation of histone H1.4 (H1-4) at Ser-187' (H1.4S187Ph), a modification associated with transcription activation. The CDK9/cyclin-K complex has also a kinase activity towards CTD of RNAP II and can substitute for CDK9/cyclin-T P-TEFb in vitro. Replication stress response protein; the CDK9/cyclin-K complex is required for genome integrity maintenance, by promoting cell cycle recovery from replication arrest and limiting single-stranded DNA amount in response to replication stress, thus reducing the breakdown of stalled replication forks and avoiding DNA damage. In addition, probable function in DNA repair of isoform 2 via interaction with KU70/XRCC6. Promotes cardiac myocyte enlargement. RPB1/POLR2A phosphorylation on 'Ser-2' in CTD activates transcription. AR phosphorylation modulates AR transcription factor promoter selectivity and cell growth. DSIF and NELF phosphorylation promotes transcription by inhibiting their negative effect. The phosphorylation of MYOD1 enhances its transcriptional activity and thus promotes muscle differentiation. Catalyzes phosphorylation of KAT5, promoting KAT5 recruitment to chromatin and histone acetyltransferase activity., [UniProtKB, UniProtKB]; Role in activating MyoD-dependent transcription, [RefSeq, PubMed]; Suppression of neuronal CDK9/p53/VDAC signaling provides bioenergetic support and improves post-stroke neuropsychiatric outcomes. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B0R020;Q3U002;Q3UMY2;Q3UPT3;Q3UQI6;Q8BTN0", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0008023 transcription elongation factor complex;GO:0016605 PML body;GO:0036464 cytoplasmic ribonucleoprotein granule", "go_biological_process": "GO:0006281 DNA repair;GO:0006468 protein phosphorylation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006366 transcription by RNA polymerase II;GO:0071345 cellular response to cytokine stimulus", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q99J95-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VC31-1", "uniprot_id": [ { "id": "CCDC9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VC31", "type": "external" } ], "mass": 61445.0, "length": 543, "protein_name": "Coiled-coil domain-containing protein 9", "gene_name": "Ccdc9", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 9 isoform 2", "refseq_ac": [ { "id": "NP_001369343", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001369343", "type": "external" } ], "gene_names_uniprotkb": "Ccdc9", "gene_names_refseq": "2600011L02Rik; Ccdc9", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 9", "protein_names_refseq": "coiled-coil domain-containing protein 9 isoform 2; coiled-coil domain-containing protein 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:243846)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "20485683;21750661;24129315;33124180", "class_list": "", "function": "Circular RNA circCCDC9 alleviates ischaemic stroke ischaemia/reperfusion injury via the Notch pathway., [RefSeq, PubMed]; Probable component of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0035145 exon-exon junction complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8VC31-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CDP0-1", "uniprot_id": [ { "id": "CBPC3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CDP0", "type": "external" } ], "mass": 116378.0, "length": 1006, "protein_name": "Cytosolic carboxypeptidase 3", "gene_name": "Agbl3", "organism": "Mouse", "refseq_name": "cytosolic carboxypeptidase 3 isoform 1", "refseq_ac": [ { "id": "NP_001276585", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276585", "type": "external" } ], "gene_names_uniprotkb": "Agbl3; Ccp3", "gene_names_refseq": "2900053G10Rik; 4930431N21Rik; 6530406M24Rik; Agbl3; CCP3", "protein_names_uniprotkb": "Cytosolic carboxypeptidase 3; 3.4.17.-; ATP/GTP-binding protein-like 3; Protein deglutamylase CCP3", "protein_names_refseq": "cytosolic carboxypeptidase 3 isoform 1; cytosolic carboxypeptidase 3; protein deglutamylase CCP3", "tax_id": 10090, "disease": "", "pathway": " (mmu:76223)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17244818;21750661;25103237", "class_list": "", "function": "CCP2 and CCP3 are deglutamylases and are highly regulated proteins confined to ciliated tissues., [RefSeq, PubMed]; Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins (PubMed:25103237). Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of tubulin protein (PubMed:25103237). Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate (PubMed:25103237). Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of non-tubulin proteins such as MYLK (PubMed:25103237). May catalyze the hydrolysis of aspartate from the carboxy-terminus of target proteins (PubMed:25103237). Does not show detyrosinase or deglycylase activities from the carboxy-terminus of target proteins (PubMed:25103237)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RSY8;Q09M06;Q09M07;Q8BSW4;Q8R036", "ec_number_list": [ { "id": "3.4.17.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.-", "type": "external" }, { "id": "3.4.17.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.24", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004181 metallocarboxypeptidase activity;GO:0015631 tubulin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0015630 microtubule cytoskeleton;GO:0005814 centriole", "go_biological_process": "GO:0006508 proteolysis;GO:0035610 protein side chain deglutamylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8CDP0-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKK8-1", "uniprot_id": [ { "id": "ATR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JKK8", "type": "external" } ], "mass": 300224.0, "length": 2635, "protein_name": "Serine/threonine-protein kinase ATR", "gene_name": "Atr", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Atr; Kiaa4069", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine/threonine-protein kinase ATR; 2.7.11.1; Ataxia telangiectasia and Rad3-related protein", "protein_names_refseq": "", "tax_id": 10090, "disease": "Seckel syndrome (Disease Ontology:DOID:0050569); non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); Seckel syndrome 1 (Disease Ontology:DOID:0070007); adenoid cystic carcinoma (Disease Ontology:DOID:0080202); Alzheimer's disease (Disease Ontology:DOID:10652); ataxia telangiectasia (Disease Ontology:DOID:12704); lung cancer (Disease Ontology:DOID:1324); endometrial cancer (Disease Ontology:DOID:1380); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); colon cancer (Disease Ontology:DOID:219); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (mmu:245000); (R-MMU-176187); (R-MMU-5685938); (R-MMU-5693607); (R-MMU-6783310); (R-MMU-6804756); (R-MMU-69473)", "pathway_count": 7, "publication_count": 20, "publication_id_list": "10691732;10801416;12629044;18299400;20801936;21183079;21750661;22549958;23039116;25428506;29125140;30084848;31219806;31599954;34203471;34428180;35822049;36210013;40885482;8843195", "class_list": "", "function": "Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor (PubMed:12629044, PubMed:8843195). Recognizes the substrate consensus sequence [ST]-Q (By similarity). Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RBBP8, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis (PubMed:12629044, PubMed:8843195). Phosphorylates 'Ser-139' of histone variant H2AX at sites of DNA damage, thereby regulating DNA damage response mechanism (By similarity). Required for FANCD2 ubiquitination (By similarity). Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication (By similarity). Acts as a regulator of the S-G2 transition by restricting the activity of CDK1 during S-phase to prevent premature entry into G2 (By similarity). Acts as a regulator of the nuclear envelope integrity in response to DNA damage and stress (By similarity). Acts as a mechanical stress sensor at the nuclear envelope: relocalizes to the nuclear envelope in response to mechanical stress and mediates a checkpoint via phosphorylation of CHEK1 (By similarity). Also promotes nuclear envelope rupture in response to DNA damage by mediating phosphorylation of LMNA at 'Ser-282', leading to lamin disassembly (By similarity). Involved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability and catalyzing phosphorylation of LMNA at 'Ser-395', priming LMNA for subsequent phosphorylation by CDK1 and micronuclei envelope rupture (By similarity). The rupture of micronuclear envelope triggers the cGAS-STING pathway thereby activating the type I interferon response and innate immunity (By similarity). Positively regulates the restart of stalled replication forks following activation by the KHDC3L-OOEP scaffold complex (PubMed:29125140). Essential for preventing the occurrence of DNA damage during early embryogenesis (PubMed:10691732, PubMed:10801416)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 12, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TBS8;Q3TNX3;Q3TZM6;Q3UT26;Q3V1V6;Q571L3", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "5.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "3.1.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0032405 MutLalpha complex binding", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0098850 extrinsic component of synaptic vesicle membrane;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm", "go_biological_process": "GO:1990166 protein localization to site of double-strand break;GO:0006281 DNA repair;GO:0006468 protein phosphorylation;GO:0000086 G2/M transition of mitotic cell cycle;GO:0000723 telomere maintenance", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q9JKK8-1", "record_type": "protein", "filter_code": "0000000.0000111.001000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54254-1", "uniprot_id": [ { "id": "ATX1_MOUSE", "url": "https://www.uniprot.org/uniprot/P54254", "type": "external" } ], "mass": 83793.0, "length": 791, "protein_name": "Ataxin-1", "gene_name": "Atxn1", "organism": "Mouse", "refseq_name": "ataxin-1 isoform b", "refseq_ac": [ { "id": "NP_001186233", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186233", "type": "external" } ], "gene_names_uniprotkb": "Atxn1; Sca1", "gene_names_refseq": "2900016G23Rik; Atx1; Atxn1; Gm10786; Sca1", "protein_names_uniprotkb": "Ataxin-1; Spinocerebellar ataxia type 1 protein homolog", "protein_names_refseq": "ataxin-1 isoform b; spinocerebellar ataxia 1 homolog", "tax_id": 10090, "disease": "spinocerebellar ataxia 1 (Disease Ontology:DOID:0050954); autosomal dominant cerebellar ataxia (Disease Ontology:DOID:1441)", "pathway": " (mmu:20238)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10.3389/fragi.2021.757801;10624951;12086639;17190598;17322884;21183079;21750661;22645316;25768905;28288114;30059200;32848054;35822049;40021952;40885482;40997131;8789437;9353121;9778246", "class_list": "", "function": "Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression (By similarity). May be involved in RNA metabolism (By similarity). In concert with CIC and ATXN1L, involved in brain development (PubMed:28288114)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q8C866", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0042802 identical protein binding;GO:0031208 POZ domain binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0060252 positive regulation of glial cell proliferation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007612 learning;GO:0007613 memory", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P54254-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R001-1", "uniprot_id": [ { "id": "ATS5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R001", "type": "external" } ], "mass": 101844.0, "length": 930, "protein_name": "A disintegrin and metalloproteinase with thrombospondin motifs 5", "gene_name": "Adamts5", "organism": "Mouse", "refseq_name": "A disintegrin and metalloproteinase with thrombospondin motifs 5 preproprotein", "refseq_ac": [ { "id": "NP_035912", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035912", "type": "external" } ], "gene_names_uniprotkb": "Adamts5", "gene_names_refseq": "9530092O11Rik; ADAM-TS5; ADAMTS11; ADAMTS1; ADMP-2; ASMP-2; Adamts5", "protein_names_uniprotkb": "A disintegrin and metalloproteinase with thrombospondin motifs 5; 3.4.24.-; ADAM-TS 5; ADAM-TS5; ADAMTS-5; ADMP-2; Aggrecanase-2; Implantin", "protein_names_refseq": "A disintegrin and metalloproteinase with thrombospondin motifs 5 preproprotein; a disintegrin and metalloproteinase with thrombospondin motifs 5; a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2); aggrecanase-2; implantin", "tax_id": 10090, "disease": "mucopolysaccharidosis VI (Disease Ontology:DOID:12800); rheumatoid arthritis (Disease Ontology:DOID:7148); osteoarthritis (Disease Ontology:DOID:8398); degenerative disc disease (Disease Ontology:DOID:90)", "pathway": " (mmu:23794); (R-MMU-1474228); (R-MMU-5173214)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10464288;15659705;15800625;23233679;26495903;27855162;28702327;30084848;38149721;38750698;39122105", "class_list": "", "function": "ADAMTS1, ADAMTS4, and ADAMTS5 are expressed in patterns that relate to the expression pattern of versican in granulosa cells of small follicles, expanded cumulus cell-oocyte complexes, and endothelial cells of the ovary., [RefSeq, PubMed]; Combined genetic-pharmacologic inactivation of tightly linked ADAMTS proteases in temporally specific windows uncovers distinct roles for versican proteolysis and glypican-6 in cardiac development., [RefSeq, PubMed]; DNA demethylation of promoter region orchestrates SPI-1-induced ADAMTS-5 expression in articular cartilage of osteoarthritis mice., [RefSeq, PubMed]; Investigation roles of Adamts1 and Adamts5 in scleral fibroblasts under hypoxia and mice with form-deprived myopia., [RefSeq, PubMed]; Metalloproteinase that plays an important role in connective tissue organization, development, inflammation and cell migration. Extracellular matrix (ECM) degrading enzyme that shows proteolytic activity toward the hyalectan group of chondroitin sulfate proteoglycans (CSPGs) including ACAN, VCAN, BCAN and NCAN. Cleavage within the hyalectans occurs at Glu-Xaa recognition motifs. Plays a role in embryonic development, including limb and cardiac morphogenesis, and skeletal muscle development through its VCAN remodeling properties. Cleaves VCAN in the pericellular matrix surrounding myoblasts, facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration (PubMed:23233679). Participates in the development of brown adipose tissue and browning of white adipose tissue (PubMed:28702327). Plays an important role for T-lymphocyte migration from draining lymph nodes following viral infection (PubMed:27855162)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; This gene encodes a member of 'a disintegrin and metalloproteinase with thrombospondin motifs' (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encoded preproprotein undergoes proteolytic processing to generate an active, zinc-dependent aggrecanase enzyme. Mice lacking the encoded protein are protected from surgery-induced osteoarthritis and antigen-induced arthritis. [provided by RefSeq, May 2016]., [RefSeq]", "predicted_glycosites": 7, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 2, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "B2RRX9", "ec_number_list": [ { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.4.24.87", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.87", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "3.4.24.82", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.82", "type": "external" }, { "id": "3.4.24.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.14", "type": "external" }, { "id": "2.4.1.221", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.221", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0008201 heparin binding;GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005654 nucleoplasm;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0022617 extracellular matrix disassembly;GO:0030198 extracellular matrix organization;GO:0007520 myoblast fusion;GO:0003203 endocardial cushion morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9R001-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000011100.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68EF6-1", "uniprot_id": [ { "id": "BEGIN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q68EF6", "type": "external" } ], "mass": 65309.0, "length": 600, "protein_name": "Brain-enriched guanylate kinase-associated protein", "gene_name": "Begain", "organism": "Mouse", "refseq_name": "brain-enriched guanylate kinase-associated protein isoform 5", "refseq_ac": [ { "id": "NP_001156647", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156647", "type": "external" } ], "gene_names_uniprotkb": "Begain", "gene_names_refseq": "Begain; Gm897", "protein_names_uniprotkb": "Brain-enriched guanylate kinase-associated protein", "protein_names_refseq": "brain-enriched guanylate kinase-associated protein isoform 5; brain-enriched guanylate kinase-associated protein; brain-enriched guanylate kinase-associated", "tax_id": 10090, "disease": "", "pathway": " (mmu:380785)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "16452087;18034455;19641963;21183079;21750661;22645316;24129315;27785460;32848054;40885482", "class_list": "", "function": "A Begain transcript variant is preferentially expressed from the paternal allele., [RefSeq, PubMed]; BEGAIN was highly localized at the synapse of inner lamina II in the spinal dorsal horn and that its expression was up-regulated after peripheral nerve injury in wild-type, but not in GluN2B Y1472F-KI, mice. Mechanical allodynia was significantly attenuated in BEGAIN-deficient mice, but no change was observed in terms of physiological threshold for mechanical stimuli. Publication Status: Online-Only, [RefSeq, PubMed]; May sustain the structure of the postsynaptic density (PSD)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0030425 dendrite", "go_biological_process": "GO:0098817 evoked excitatory postsynaptic potential", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q68EF6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CDJ3-1", "uniprot_id": [ { "id": "BAKOR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CDJ3", "type": "external" } ], "mass": 55388.0, "length": 492, "protein_name": "Beclin 1-associated autophagy-related key regulator", "gene_name": "Atg14", "organism": "Mouse", "refseq_name": "beclin 1-associated autophagy-related key regulator", "refseq_ac": [ { "id": "NP_766187", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766187", "type": "external" } ], "gene_names_uniprotkb": "Atg14; Atg14L; D14Ertd436e; Kiaa0831", "gene_names_refseq": "4832427M01; Atg14L; Atg14; D14Ertd114e; D14Ertd436e", "protein_names_uniprotkb": "Beclin 1-associated autophagy-related key regulator; Atg14L; Autophagy-related protein 14-like protein; Barkor", "protein_names_refseq": "Atg14-like protein; VATG14 autophagy related 14 homolog; autophagy-related protein 14-like protein; barkor; beclin 1-associated autophagy-related key regulator", "tax_id": 10090, "disease": "", "pathway": " (mmu:100504663); (R-MMU-1632852)", "pathway_count": 2, "publication_count": 28, "publication_id_list": "18299400;18843052;19270693;19270696;20484733;20639694;21059846;21518905;21750661;21952136;22745922;22863730;22872234;22992773;23332761;24089209;24849286;25428506;27938392;30084848;30779550;31599954;34203471;34428180;34428398;35820727;36210013;40885482", "class_list": "", "function": "Beclin 1 and its binding proteins orchestrate the precise function of the class III PI(3)K in regulating autophagy at multiple steps., [RefSeq, PubMed]; Required for both basal and inducible autophagy (PubMed:19270693, PubMed:19270696). Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1 (By similarity). Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine (PubMed:19270693, PubMed:19270696). Promotes BECN1 translocation from the trans-Golgi network to autophagosomes (By similarity). Enhances PIK3C3 activity in a BECN1-dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1 (By similarity). Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation of PIK3C3 by AMPK (PubMed:23332761). Binds to STX17-SNAP29 binary t-SNARE complex on autophagosomes and primes it for VAMP8 interaction to promote autophagosome-endolysosome fusion (By similarity). Modulates the hepatic lipid metabolism (PubMed:22992773)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; These results suggest that mammalian cells have at least two distinct class III PI3-kinase complexes, and that beclin 1 interacts distinctly with mammalian Atg14 and UVRAG in two of these complexes., [RefSeq, PubMed]; Two Beclin 1 associated proteins, Atg14L and Rubicon, were identified., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q69ZY1;Q6PFY6;Q8C6N0;Q8R3M3", "ec_number_list": [], "go_molecular_function": "GO:0051020 GTPase binding;GO:0043495 protein-membrane adaptor activity;GO:0035014 phosphatidylinositol 3-kinase regulator activity;GO:0141039 phosphatidylinositol 3-kinase inhibitor activity", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005789 endoplasmic reticulum membrane;GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site;GO:0045335 phagocytic vesicle;GO:0005776 autophagosome", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process;GO:0000045 autophagosome assembly;GO:0001934 positive regulation of protein phosphorylation;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "Q8CDJ3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BI72-1", "uniprot_id": [ { "id": "CARF_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BI72", "type": "external" } ], "mass": 59745.0, "length": 563, "protein_name": "CDKN2A-interacting protein", "gene_name": "Cdkn2aip", "organism": "Mouse", "refseq_name": "CDKN2A-interacting protein isoform 1", "refseq_ac": [ { "id": "NP_765995", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_765995", "type": "external" } ], "gene_names_uniprotkb": "Cdkn2aip; Carf", "gene_names_refseq": "4921511I16Rik; Cdkn2aip", "protein_names_uniprotkb": "CDKN2A-interacting protein; Collaborator of ARF", "protein_names_refseq": "CDKN2A-interacting protein isoform 1; collaborates/cooperates with ARF (alternate reading frame) protein; collaborator of ARF", "tax_id": 10090, "disease": "", "pathway": " (mmu:70925)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;12581788;18555516;21183079;21750661;22645316;27829235;28528544;29187734;36852467", "class_list": "", "function": "CARF may act as a novel key regulator of the p53 pathway at multiple checkpoints Review article, [RefSeq, PubMed]; Oncogenic functions of CARF in hepatocellular carcinoma tumorigenesis is a result of activation of beta-catenin/TCF signaling., [RefSeq, PubMed]; Regulates DNA damage response and cell proliferation in a dose-dependent manner through a number of signaling pathways involved in cell proliferation, apoptosis and senescence., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0002039 p53 binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0001652 granular component", "go_biological_process": "GO:0030307 positive regulation of cell growth;GO:0006974 DNA damage response;GO:0030308 negative regulation of cell growth;GO:0031647 regulation of protein stability;GO:0009967 positive regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8BI72-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AIV8-1", "uniprot_id": [ { "id": "CARD9_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AIV8", "type": "external" } ], "mass": 62462.0, "length": 536, "protein_name": "Caspase recruitment domain-containing protein 9", "gene_name": "Card9", "organism": "Mouse", "refseq_name": "caspase recruitment domain-containing protein 9", "refseq_ac": [ { "id": "NP_001032836", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032836", "type": "external" } ], "gene_names_uniprotkb": "Card9", "gene_names_refseq": "Card9; Gm782", "protein_names_uniprotkb": "Caspase recruitment domain-containing protein 9", "protein_names_refseq": "caspase recruitment domain-containing protein 9", "tax_id": 10090, "disease": "primary immunodeficiency disease (Disease Ontology:DOID:612); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (mmu:332579); (R-MMU-5607764)", "pathway_count": 2, "publication_count": 21, "publication_id_list": "16862125;17187069;17450144;17486093;17514206;20484733;20538615;21183079;22265677;23732773;24470469;24960071;25267792;25621893;26679537;27158904;29080677;32358020;32548948;33548172;34428180", "class_list": "", "function": "Activation of lymphoid and myeloid cells through Immunoreceptor tyrosine-based activation motifs-associated receptors or Toll-like receptors is regulated by CARMA1-Bcl-10 and CARD9-Bcl-10, respectively, [RefSeq, PubMed]; Adapter protein that plays a key role in innate immune response against fungi by forming signaling complexes downstream of C-type lectin receptors (PubMed:16862125, PubMed:20538615, PubMed:26679537, PubMed:29080677). CARD9-mediated signals are essential for antifungal immunity against a subset of fungi from the phylum Ascomycota (PubMed:16862125, PubMed:20538615, PubMed:24470469, PubMed:25621893, PubMed:26679537, PubMed:29080677, PubMed:32548948). Transduces signals in myeloid cells downstream of C-type lectin receptors CLEC7A (dectin-1), CLEC6A (dectin-2) and CLEC4E (Mincle), which detect pathogen-associated molecular pattern metabolites (PAMPs), such as fungal carbohydrates, and trigger CARD9 activation (PubMed:16862125, PubMed:20538615). Upon activation, CARD9 homooligomerizes to form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10 and subsequent recruitment of MALT1: this leads to activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:16862125, PubMed:20538615, PubMed:22265677, PubMed:29080677). CARD9 signaling in antigen-presenting cells links innate sensing of fungi to the activation of adaptive immunity and provides a cytokine milieu that induces the development and subsequent of interleukin 17-producing T helper (Th17) cells (PubMed:17450144, PubMed:24470469, PubMed:32358020). Also involved in activation of myeloid cells via classical ITAM-associated receptors and TLR: required for TLR-mediated activation of MAPK, while it is not required for TLR-induced activation of NF-kappa-B (PubMed:17486093). CARD9 can also be engaged independently of BCL10: forms a complex with RASGRF1 downstream of C-type lectin receptors, which recruits and activates HRAS, leading to ERK activation and the production of cytokines (PubMed:25267792). Acts as an important regulator of the intestinal commensal fungi (mycobiota) component of the gut microbiota (PubMed:27158904, PubMed:33548172). Plays an essential role in antifungal immunity against dissemination of gut fungi: acts by promoting induction of antifungal IgG antibodies response in CX3CR1(+) macrophages to confer protection against disseminated C.albicans or C.auris infection (PubMed:33548172). Also mediates immunity against other pathogens, such as certain bacteria, viruses and parasites; CARD9 signaling is however redundant with other innate immune responses (PubMed:17187069, PubMed:26679537, PubMed:29080677). In response to L.monocytogenes infection, required for the production of inflammatory cytokines activated by intracellular peptidoglycan: acts by connecting NOD2 recognition of peptidoglycan to downstream activation of MAP kinases (MAPK) without activating NF-kappa-B (PubMed:17187069)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; CARD9 has a critical function in Nod2-mediated activation of p38 and Jnk in innate immune responses to intracellular pathogens, [RefSeq, PubMed]; Card9 is a key transducer of Dectin-1 signalling, where Dectin-1 is the major mammalian pattern recognition receptor for the fungal component zymosan, in antifungal immunity, [RefSeq, PubMed]; Signaling through Syk and CARD9 can couple innate to adaptive immunity independently of Toll-like receptor signals, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0035591 signaling adaptor activity;GO:0050700 CARD domain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0032991 protein-containing complex;GO:0032449 CBM complex", "go_biological_process": "GO:0032740 positive regulation of interleukin-17 production;GO:0007165 signal transduction;GO:0046330 positive regulation of JNK cascade;GO:0050830 defense response to Gram-positive bacterium;GO:0051260 protein homooligomerization", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "A2AIV8-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O09161-1", "uniprot_id": [ { "id": "CASQ2_MOUSE", "url": "https://www.uniprot.org/uniprot/O09161", "type": "external" } ], "mass": 48176.0, "length": 415, "protein_name": "Calsequestrin-2", "gene_name": "Casq2", "organism": "Mouse", "refseq_name": "calsequestrin-2 isoform 2 precursor", "refseq_ac": [ { "id": "NP_033944", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033944", "type": "external" } ], "gene_names_uniprotkb": "Casq2", "gene_names_refseq": "Casq2; Csq2; ESTM52; cCSQ", "protein_names_uniprotkb": "Calsequestrin-2; Calsequestrin, cardiac muscle isoform", "protein_names_refseq": "calsequestrin-2 isoform 2 precursor; cardiac calsequestrin", "tax_id": 10090, "disease": "catecholaminergic polymorphic ventricular tachycardia 2 (Disease Ontology:DOID:0060676); COVID-19 (Disease Ontology:DOID:0080600); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); alcohol use disorder (Disease Ontology:DOID:1574); supravalvular aortic stenosis (Disease Ontology:DOID:1929); congestive heart failure (Disease Ontology:DOID:6000); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:12373); (R-MMU-2672351); (R-MMU-5578775)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "16932808;17607358;19920148;21183079;21750661;35312907;36210013;36288343;37507081;9795116", "class_list": "", "function": "Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Effects of acute ischemia and hypoxia in young and adult calsequestrin (CSQ2) knock-out and wild-type mice., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O88505;Q56A03", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0048306 calcium-dependent protein binding;GO:0005080 protein kinase C binding;GO:0005509 calcium ion binding;GO:0140314 calcium ion sequestering activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030018 Z disc;GO:0016529 sarcoplasmic reticulum;GO:0033018 sarcoplasmic reticulum lumen;GO:0030314 junctional membrane complex", "go_biological_process": "GO:0006874 intracellular calcium ion homeostasis;GO:0060306 regulation of membrane repolarization;GO:0060048 cardiac muscle contraction;GO:0043267 negative regulation of potassium ion transport;GO:0045214 sarcomere organization", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O09161-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24788-1", "uniprot_id": [ { "id": "CD11B_MOUSE", "url": "https://www.uniprot.org/uniprot/P24788", "type": "external" } ], "mass": 91513.0, "length": 784, "protein_name": "Cyclin-dependent kinase 11B", "gene_name": "Cdk11b", "organism": "Mouse", "refseq_name": "cyclin-dependent kinase 11B isoform 2", "refseq_ac": [ { "id": "NP_001334237", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334237", "type": "external" } ], "gene_names_uniprotkb": "Cdk11b; Cdc2l1; Cdk11", "gene_names_refseq": "CDK11-p110; CDK11-p46; CDK11-p58; Cdc11b; Cdc2l1; Cdc2l2; Cdk11b; Cdk11; p58", "protein_names_uniprotkb": "Cyclin-dependent kinase 11B; 2.7.11.22; 2.7.11.23; Cell division cycle 2-like protein kinase 1; Cell division protein kinase 11; Cyclin-dependent kinase 11; Galactosyltransferase-associated protein kinase p58/GTA; PITSLRE serine/threonine-protein kinase CDC2L1", "protein_names_refseq": "PITSLRE proteins; PITSLRE serine/threonine-protein kinase CDC2L1; cell division cycle 2 homolog-like 1; cell division cycle 2 homolog-like 2; cell division cycle 2-like 1; cell division cycle 2-like 2; cell division cycle 2-like protein kinase 1; cell division protein kinase 11; cyclin-dependent kinase 11B isoform 2; cyclin-dependent kinase 11; galactosyltransferase-associated protein kinase p58/GTA", "tax_id": 10090, "disease": "", "pathway": " (mmu:12537); (R-MMU-380270)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "15060143;15345747;17242355;2069872;21183079;21750661;21952136;28101846;33664748;39627609;7528743", "class_list": "", "function": "CDK11 Promotes Cytokine-Induced Apoptosis in Pancreatic Beta Cells Independently of Glucose Concentration and Is Regulated by Inflammation in the NOD Mouse Model. Publication Status: Online-Only, [RefSeq, PubMed]; Cyclin-dependent protein kinase that acts as a regulator of transcription and pre-mRNA splicing (By similarity). Acts as a key regulator of pre-mRNA splicing by mediating phosphorylation of SF3B1, enabling the association between SF3B1 and U5 and U6 snRNAs in the activated spliceosome, thereby promoting spliceosome assembly (By similarity). Also acts as a regulator of transcription by phosphorylating 'Ser-2' of the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A (By similarity). Involved in replication-dependent transcription of histone genes: binds to histone genes and phosphorylates POLR2A at 'Ser-2' of the CTD to specifically control transcriptional elongation of histones and recruitment of 3'-end processing factors (By similarity). Part of a transcription checkpoint upstream of CDK9, which regulates promoter-proximal pausing by RNA polymerase II, a transcription halt following transcription initiation, but prior to elongation (By similarity). Probably regulates promoter-proximal pausing by mediating phosphorylation of POLR2A at 'Ser-2' of the CTD (By similarity). Activated by the CDK-activating kinase (CAK) complex consisting of CDK7, cyclin-H/CCNH and MAT1, which is a master regulator of CDK activity (By similarity)., [UniProtKB, UniProtKB]; Isoform expressed in a non-cell cycle-dependent manner., [UniProtKB, UniProtKB]; Isoform specifically expressed during the G2-M phases of the cell cycle. Phosphorylates 'Ser-2' of the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A. Promotes centromeric transcription to maintain centromeric cohesion during mitosis., [UniProtKB, UniProtKB]; Suggested that CDK11p58 acted to regulate microglia activation through CDK11p58 and cyclin D3 interaction, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UI03;Q61399;Q7TST4;Q8BP53", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0106310 protein serine kinase activity;GO:0140834 RNA polymerase II CTD heptapeptide repeat S2 kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0000775 chromosome, centromeric region", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0042981 regulation of apoptotic process;GO:0043484 regulation of RNA splicing;GO:0007088 regulation of mitotic nuclear division", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P24788-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P25322-1", "uniprot_id": [ { "id": "CCND1_MOUSE", "url": "https://www.uniprot.org/uniprot/P25322", "type": "external" } ], "mass": 33429.0, "length": 295, "protein_name": "G1/S-specific cyclin-D1", "gene_name": "Ccnd1", "organism": "Mouse", "refseq_name": "G1/S-specific cyclin-D1 isoform 2", "refseq_ac": [ { "id": "NP_031657", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031657", "type": "external" } ], "gene_names_uniprotkb": "Ccnd1; Cyl-1", "gene_names_refseq": "Ccnd1; CycD1; Cyl-1; PRAD1; bcl-1; cD1", "protein_names_uniprotkb": "G1/S-specific cyclin-D1", "protein_names_refseq": "G1/S-specific cyclin-D1 isoform 2; G1/S-specific cyclin-D1", "tax_id": 10090, "disease": "mantle cell lymphoma (Disease Ontology:DOID:0050746); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); colon adenoma (Disease Ontology:DOID:0050912); non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); ductal carcinoma in situ (Disease Ontology:DOID:0060074); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); polycystic ovary syndrome (Disease Ontology:DOID:11612); penile benign neoplasm (Disease Ontology:DOID:11624); interstitial cystitis (Disease Ontology:DOID:13949); von Hippel-Lindau disease (Disease Ontology:DOID:14175); squamous cell carcinoma (Disease Ontology:DOID:1749); pancreatic cancer (Disease Ontology:DOID:1793); status epilepticus (Disease Ontology:DOID:1824); impotence (Disease Ontology:DOID:1875); atherosclerosis (Disease Ontology:DOID:1936); transitional cell carcinoma (Disease Ontology:DOID:2671); malignant astrocytoma (Disease Ontology:DOID:3069); high grade glioma (Disease Ontology:DOID:3070); invasive lobular carcinoma (Disease Ontology:DOID:3457); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); liver cancer (Disease Ontology:DOID:3571); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); papillary thyroid carcinoma (Disease Ontology:DOID:3969); ovarian carcinoma (Disease Ontology:DOID:4001); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); renal cell carcinoma (Disease Ontology:DOID:4450); bronchiolo-alveolar adenocarcinoma (Disease Ontology:DOID:4926); lung small cell carcinoma (Disease Ontology:DOID:5409); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); pancreatic solid pseudopapillary carcinoma (Disease Ontology:DOID:6827); hepatocellular carcinoma (Disease Ontology:DOID:684); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:12443); (R-MMU-187577); (R-MMU-3214858); (R-MMU-69231); (R-MMU-75815); (R-MMU-8849470); (R-MMU-8878166); (R-MMU-8934593); (R-MMU-8951936); (R-MMU-9754119); (R-MMU-9929491)", "pathway_count": 11, "publication_count": 19, "publication_id_list": "11124803;15546868;16103118;17081987;1827757;19767775;22510880;24312406;24806449;26137553;28797244;31219806;33854232;34428180;35210557;7774959;8534916;9136925;9832503", "class_list": "", "function": "Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also a substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 40, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0019899 enzyme binding;GO:0019901 protein kinase binding;GO:0003714 transcription corepressor activity;GO:0042826 histone deacetylase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005923 bicellular tight junction", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006468 protein phosphorylation;GO:0008283 cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P25322-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28662-1", "uniprot_id": [ { "id": "BRI3_MOUSE", "url": "https://www.uniprot.org/uniprot/P28662", "type": "external" } ], "mass": 13643.0, "length": 125, "protein_name": "Membrane protein BRI3", "gene_name": "Bri3", "organism": "Mouse", "refseq_name": "membrane protein BRI3 isoform 1", "refseq_ac": [ { "id": "NP_061242", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061242", "type": "external" } ], "gene_names_uniprotkb": "Bri3", "gene_names_refseq": "Bri3; Gm38675; I3", "protein_names_uniprotkb": "Membrane protein BRI3; Brain protein I3", "protein_names_refseq": "membrane protein BRI3 isoform 1; membrane protein BRI3", "tax_id": 10090, "disease": "", "pathway": " (mmu:55950); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "12106288;14592447;21750661;27802388;30084848", "class_list": "", "function": "Bri3 appears to play an important role in TNF-induced cell death and may be localized to lysosome and function through lysosome., [RefSeq, PubMed]; Participates in tumor necrosis factor-alpha (TNF)-induced cell death (Ref.4). May be a target of Wnt/beta-catenin signaling in the liver (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q501N3;Q9Z1S1", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0048471 perinuclear region of cytoplasm;GO:0005765 lysosomal membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P28662-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D4K7-1", "uniprot_id": [ { "id": "TEKL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D4K7", "type": "external" } ], "mass": 57304.0, "length": 499, "protein_name": "Tektin-like protein 1", "gene_name": "Tektl1", "organism": "Mouse", "refseq_name": "tektin-like protein 1", "refseq_ac": [ { "id": "NP_081906", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081906", "type": "external" } ], "gene_names_uniprotkb": "Tektl1; Ccdc105", "gene_names_refseq": "4931413A09Rik; Ccdc105; Tektl1", "protein_names_uniprotkb": "Tektin-like protein 1; Coiled-coil domain-containing protein 105", "protein_names_refseq": "coiled-coil domain containing 105; coiled-coil domain-containing protein 105; tektin-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:70976)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21183079;37295417;37865089;37989994", "class_list": "", "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in sperm flagellar axoneme, which is required for motile flagellum beating (PubMed:37295417, PubMed:37865089, PubMed:37989994). Forms an extensive interaction network cross-linking the lumen of axonemal doublet microtubules (PubMed:37865089)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "G3X9S0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0036126 sperm flagellum;GO:0160112 axonemal B tubule inner sheath", "go_biological_process": "GO:0030317 flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9D4K7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WVG6-1", "uniprot_id": [ { "id": "CARM1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WVG6", "type": "external" } ], "mass": 65854.0, "length": 608, "protein_name": "Histone-arginine methyltransferase CARM1", "gene_name": "Carm1", "organism": "Mouse", "refseq_name": "histone-arginine methyltransferase CARM1 isoform 1", "refseq_ac": [ { "id": "NP_067506", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067506", "type": "external" } ], "gene_names_uniprotkb": "Carm1; Prmt4", "gene_names_refseq": "Carm1; Prmt4; m9Bei", "protein_names_uniprotkb": "Histone-arginine methyltransferase CARM1; 2.1.1.319; Coactivator-associated arginine methyltransferase 1; Protein arginine N-methyltransferase 4", "protein_names_refseq": "histone-arginine methyltransferase CARM1 isoform 1; histone-arginine methyltransferase CARM1; protein arginine N-methyltransferase 4; protein arginine methyltransferase", "tax_id": 10090, "disease": "hepatocellular adenoma (Disease Ontology:DOID:0050868); estrogen-receptor positive breast cancer (Disease Ontology:DOID:0060075); asthma (Disease Ontology:DOID:2841); hepatocellular carcinoma (Disease Ontology:DOID:684); prostate carcinoma in situ (Disease Ontology:DOID:8634)", "pathway": " (mmu:59035); (R-MMU-3214858); (R-MMU-400206); (R-MMU-9018519); (R-MMU-9707564)", "pathway_count": 5, "publication_count": 45, "publication_id_list": "10381882;11341840;11701890;11713257;11747826;11751582;11850402;11983685;11997499;12237300;12351636;12498683;12756295;14966289;15186775;15339660;15616592;16322096;16508003;17218272;17882261;18188184;18840611;19843527;19897492;21138967;21750661;25153642;25428506;25585345;28135057;28528544;28637674;30084848;30366907;31219806;33300544;34428180;35822049;36064721;36852467;37507081;38223978;40885482;40997131", "class_list": "", "function": "Epigenetic Regulation of Cardiomyocyte Maturation by Arginine Methyltransferase CARM1., [RefSeq, PubMed]; Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability (PubMed:10381882, PubMed:11341840, PubMed:11997499, PubMed:14966289, PubMed:17218272, PubMed:19897492, PubMed:21138967). Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activation of transcription via chromatin remodeling (PubMed:10381882, PubMed:11341840, PubMed:11747826, PubMed:11751582, PubMed:11997499, PubMed:12498683, PubMed:15339660, PubMed:15616592). During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription (PubMed:11997499, PubMed:16322096, PubMed:17882261, PubMed:19843527). During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C (PubMed:11713257). During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B (PubMed:11983685). Acts as a coactivator for PPARG, promotes adipocyte differentiation and the accumulation of brown fat tissue (PubMed:18188184). Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors (PubMed:21138967). Also seems to be involved in p53/TP53 transcriptional activation (PubMed:15186775). Methylates EP300/P300, both at 'Arg-2142', which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580' and 'Arg-604' in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation (PubMed:11701890). Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs (PubMed:11850402, PubMed:12237300, PubMed:12756295). Acts as a transcriptional coactivator of ACACA/acetyl-CoA carboxylase by enriching H3R17 methylation at its promoter, thereby positively regulating fatty acid synthesis (PubMed:30366907). Independently of its methyltransferase activity, involved in replication fork progression: promotes PARP1 recruitment to replication forks, leading to poly-ADP-ribosylation of chromatin at replication forks and reduced fork speed (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 13, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q3TYB9;Q8K1Y5;Q91W24;Q99KX8", "ec_number_list": [ { "id": "2.1.1.319", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.319", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.3.1.57", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.57", "type": "external" } ], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0000976 transcription cis-regulatory region binding;GO:0008276 protein methyltransferase activity;GO:0016274 protein-arginine N-methyltransferase activity;GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity", "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0008284 positive regulation of cell population proliferation;GO:0045600 positive regulation of fat cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 5.4, "record_id": "Q9WVG6-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30285-1", "uniprot_id": [ { "id": "CDK4_MOUSE", "url": "https://www.uniprot.org/uniprot/P30285", "type": "external" } ], "mass": 33751.0, "length": 303, "protein_name": "Cyclin-dependent kinase 4", "gene_name": "Cdk4", "organism": "Mouse", "refseq_name": "cyclin-dependent kinase 4 isoform 1", "refseq_ac": [ { "id": "NP_034000", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034000", "type": "external" } ], "gene_names_uniprotkb": "Cdk4; Crk3", "gene_names_refseq": "Cdk4; Crk3", "protein_names_uniprotkb": "Cyclin-dependent kinase 4; 2.7.11.22; CRK3; Cell division protein kinase 4; PSK-J3", "protein_names_refseq": "PSK-J3; cell division protein kinase 4; cyclin-dependent kinase 4 isoform 1; p34/cdk4; serine/threonine kinase", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); intellectual disability (Disease Ontology:DOID:1059); cystinosis (Disease Ontology:DOID:1064); urinary bladder cancer (Disease Ontology:DOID:11054); prostatic hypertrophy (Disease Ontology:DOID:11132); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); pancreatic cancer (Disease Ontology:DOID:1793); islet cell tumor (Disease Ontology:DOID:1799); nephroblastoma (Disease Ontology:DOID:2154); transitional cell carcinoma (Disease Ontology:DOID:2671); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); breast carcinoma (Disease Ontology:DOID:3459); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684); familial melanoma (Disease Ontology:DOID:6846); non-functioning pancreatic endocrine tumor (Disease Ontology:DOID:7698); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); type 2 diabetes mellitus (Disease Ontology:DOID:9352); encephalitis (Disease Ontology:DOID:9588); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:12567); (R-MMU-187577); (R-MMU-2559580); (R-MMU-2559582); (R-MMU-2559585); (R-MMU-3214858); (R-MMU-69231); (R-MMU-75815); (R-MMU-8849470); (R-MMU-8878166); (R-MMU-9616222); (R-MMU-9754119); (R-MMU-9929491)", "pathway_count": 13, "publication_count": 15, "publication_id_list": "10580009;1281307;1423597;15107404;19767775;21750661;28135057;28528544;30084848;30485818;34428180;37955182;39218392;8139570;8444355", "class_list": "", "function": "Cyclin D-CDK4 Disulfide Bond Attenuates Pulmonary Vascular Cell Proliferation., [RefSeq, PubMed]; Cyclin-dependent kinase 4 drives cystic kidney disease in the absence of mTORC1 signaling activity., [RefSeq, PubMed]; Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 28, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "5.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.1", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.1.1.320", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.320", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0044877 protein-containing complex binding;GO:0016301 kinase activity;GO:0004693 cyclin-dependent protein serine/threonine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007165 signal transduction;GO:0008284 positive regulation of cell population proliferation;GO:0010971 positive regulation of G2/M transition of mitotic cell cycle;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P30285-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27545-1", "uniprot_id": [ { "id": "CERS1_MOUSE", "url": "https://www.uniprot.org/uniprot/P27545", "type": "external" } ], "mass": 40100.0, "length": 350, "protein_name": "Ceramide synthase 1", "gene_name": "Cers1", "organism": "Mouse", "refseq_name": "ceramide synthase 1", "refseq_ac": [ { "id": "NP_619588", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_619588", "type": "external" } ], "gene_names_uniprotkb": "Cers1; Lass1; Uog-1; Uog1", "gene_names_refseq": "Cers1; Lass1; Uog-1; to", "protein_names_uniprotkb": "Ceramide synthase 1; 2.3.1.24; 2.3.1.299; CerS1; Longevity assurance gene 1 protein homolog 1; Protein UOG-1; Sphingoid base N-stearoyltransferase CERS1; Sphingosine N-acyltransferase CERS1", "protein_names_refseq": "LAG1 homolog, ceramide synthase 1; LAG1 longevity assurance homolog 1; ceramide synthase 1; longevity assurance gene 1 protein homolog 1; protein UOG-1; sphingoid base N-stearoyltransferase CERS1", "tax_id": 10090, "disease": "progressive myoclonus epilepsy 8 (Disease Ontology:DOID:0111451)", "pathway": " (mmu:93898); (R-MMU-1660661)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "12105227;15823095;16951403;17977534;18541923;2034669;21625621;26620563;30605666;34428180;35053322;38506902", "class_list": "glycogene", "function": "CerS1 but Not CerS5 Gene Silencing, Improves Insulin Sensitivity and Glucose Uptake in Skeletal Muscle. Publication Status: Online-Only, [RefSeq, PubMed]; Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward stearoyl-CoA (octadecanoyl-CoA; C18:0-CoA). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively (PubMed:12105227, PubMed:16951403, PubMed:17977534, PubMed:18541923, PubMed:30605666). Plays a predominant role in skeletal muscle in regulating C18 ceramide and dihydroceramide levels with an impact on whole-body glucose metabolism and insulin sensitivity. Protects from diet-induced obesity by suppressing the uptake of glucose in multiple organs in a FGF21-dependent way (PubMed:30605666). Generates C18 ceramides in the brain, playing a critical role in cerebellar development and Purkinje cell function (PubMed:21625621). In response to cellular stress mediates mitophagy, a known defense mechanism against cell transformation and aging. Upon mitochondria fission, generates C18 ceramides that anchor lipidated MAP1LC3B/LC3B-II autophagolysosomes to outer mitochondrial membranes to eliminate damaged mitochondria (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Inhibition of CERS1 in skeletal muscle exacerbates age-related muscle dysfunction. Erratum:[Elife. 2024 May 20;13:e99846. doi: 10.7554/eLife.99846. PMID: 38767943] Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a ceramide synthase enzyme, which catalyzes the synthesis of ceramide, the hydrophobic moiety of sphingolipids. The encoded enzyme synthesizes 18-carbon (C18) ceramide in brain neurons. Mice lacking a functional copy of this gene exhibit impaired cerebellar development, locomotion and motor coordination. This protein is transcribed from a bicistronic mRNA, which also encodes growth differentiation factor 1. [provided by RefSeq, Jul 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 17, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.24", "type": "external" }, { "id": "2.3.1.299", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.299", "type": "external" }, { "id": "2.3.1.298", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.298", "type": "external" }, { "id": "2.3.1.297", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.297", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.291", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.291", "type": "external" } ], "go_molecular_function": "GO:0016410 N-acyltransferase activity;GO:0050291 sphingosine N-acyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:1901526 positive regulation of mitophagy;GO:0046513 ceramide biosynthetic process;GO:0030148 sphingolipid biosynthetic process;GO:0071466 cellular response to xenobiotic stimulus;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P27545-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0000000000000.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47746-1", "uniprot_id": [ { "id": "CNR1_MOUSE", "url": "https://www.uniprot.org/uniprot/P47746", "type": "external" } ], "mass": 52831.0, "length": 473, "protein_name": "Cannabinoid receptor 1", "gene_name": "Cnr1", "organism": "Mouse", "refseq_name": "cannabinoid receptor 1", "refseq_ac": [ { "id": "NP_031752", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031752", "type": "external" } ], "gene_names_uniprotkb": "Cnr1", "gene_names_refseq": "CB-R; CB1A; CB1B; CB1R; CB1; Cnr1", "protein_names_uniprotkb": "Cannabinoid receptor 1; Brain-type cannabinoid receptor; CB-R; CB1", "protein_names_refseq": "brain-type cannabinoid receptor; cannabinoid receptor 1 (brain); cannabinoid receptor 1; striatal cannabinoid receptor type 1 protein", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); Parkinsonism (Disease Ontology:DOID:0080855); hypertension (Disease Ontology:DOID:10763); alcohol use disorder (Disease Ontology:DOID:1574); status epilepticus (Disease Ontology:DOID:1824); impotence (Disease Ontology:DOID:1875); focal epilepsy (Disease Ontology:DOID:2234); schizophrenia (Disease Ontology:DOID:5419); peptic ulcer disease (Disease Ontology:DOID:750); type 2 diabetes mellitus (Disease Ontology:DOID:9352); cannabis abuse (Disease Ontology:DOID:9505); diabetic neuropathy (Disease Ontology:DOID:9743); obesity (Disease Ontology:DOID:9970); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:12801); (R-MMU-373076); (R-MMU-418594)", "pathway_count": 3, "publication_count": 21, "publication_id_list": "10.1101/2023.09.13.557529;10891614;15606779;15864349;21183079;21987372;22388959;22841573;23955712;24719095;25707796;25869131;26671069;27826249;27828947;30016717;30084848;34428180;8777318;8832654;9888857", "class_list": "", "function": "G protein-coupled receptor for cannabinoids, including endocannabinoids (eCBs), such as N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG) (PubMed:22388959, PubMed:9888857). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain (PubMed:27828947, PubMed:9888857). Signaling typically involves reduction in cyclic AMP (PubMed:27828947, PubMed:8832654). In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while decreases respiration at high doses (PubMed:25707796, PubMed:27828947). At high doses, CNR1 signal transduction involves G protein alpha-i protein activation and subsequent inhibition of mitochondrial soluble adenylate cyclase, decrease in cyclic AMP concentration, inhibition of protein kinase A (PKA)-dependent phosphorylation of specific subunits of the mitochondrial electron transport system, including NDUFS2 (PubMed:27828947). In the hypothalamus, inhibits leptin-induced reactive oxygen species (ROS) formation and mediates cannabinoid-induced increase in SREBF1 and FASN gene expression (PubMed:25869131). In response to cannabinoids, drives the release of orexigenic beta-endorphin, but not that of melanocyte-stimulating hormone alpha/alpha-MSH, from hypothalamic POMC neurons, hence promoting food intake (PubMed:25707796). In the hippocampus, regulates cellular respiration and energy production in response to cannabinoids. Involved in cannabinoid-dependent depolarization-induced suppression of inhibition (DSI), a process in which depolarization of CA1 postsynaptic pyramidal neurons mobilizes eCBs, which retrogradely activate presynaptic CB1 receptors, transiently decreasing GABAergic inhibitory neurotransmission (PubMed:22388959). Also reduces excitatory synaptic transmission (PubMed:27828947). In superior cervical ganglions and cerebral vascular smooth muscle cells, inhibits voltage-gated Ca(2+) channels in a constitutive, as well as agonist-dependent manner (By similarity). In cerebral vascular smooth muscle cells, cannabinoid-induced inhibition of voltage-gated Ca(2+) channels leads to vasodilation and decreased vascular tone (By similarity). Induces leptin production in adipocytes and reduces LRP2-mediated leptin clearance in the kidney, hence participating in hyperleptinemia (PubMed:22841573). In adipose tissue, CNR1 signaling leads to increased expression of SREBF1, ACACA and FASN genes (PubMed:15864349). In the liver, activation by endocannabinoids leads to increased de novo lipogenesis and reduced fatty acid catabolism, associated with increased expression of SREBF1/SREBP-1, GCK, ACACA, ACACB and FASN genes (PubMed:15864349, PubMed:21987372). May also affect de novo cholesterol synthesis and HDL-cholesteryl ether uptake (PubMed:21987372). Peripherally modulates energy metabolism. In high carbohydrate diet-induced obesity, may decrease the expression of mitochondrial dihydrolipoyl dehydrogenase/DLD in striated muscles, as well as that of selected glucose/ pyruvate metabolic enzymes, hence affecting energy expenditure through mitochondrial metabolism (PubMed:26671069). In response to cannabinoid anandamide, elicits a pro-inflammatory response in macrophages, which involves NLRP3 inflammasome activation and IL1B and IL18 secretion. In macrophages infiltrating pancreatic islets, this process may participate in the progression of type-2 diabetes and associated loss of pancreatic beta-cells (PubMed:23955712)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 15, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q5SF33", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0042802 identical protein binding;GO:0004949 cannabinoid receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:1900452 regulation of long-term synaptic depression;GO:0098921 retrograde trans-synaptic signaling by endocannabinoid;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007611 learning or memory", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P47746-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62956-1", "uniprot_id": [ { "id": "CCG7_MOUSE", "url": "https://www.uniprot.org/uniprot/P62956", "type": "external" } ], "mass": 31003.0, "length": 275, "protein_name": "Voltage-dependent calcium channel gamma-7 subunit", "gene_name": "Cacng7", "organism": "Mouse", "refseq_name": "voltage-dependent calcium channel gamma-7 subunit isoform 1", "refseq_ac": [ { "id": "NP_573452", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_573452", "type": "external" } ], "gene_names_uniprotkb": "Cacng7", "gene_names_refseq": "Cacng7", "protein_names_uniprotkb": "Voltage-dependent calcium channel gamma-7 subunit; Neuronal voltage-gated calcium channel gamma-7 subunit; TARP gamma-7; Transmembrane AMPAR regulatory protein gamma-7", "protein_names_refseq": "TARP gamma-7; neuronal voltage-gated calcium channel gamma-7 subunit; transmembrane AMPAR regulatory protein gamma-7; voltage-dependent calcium channel gamma-7 subunit isoform 1; voltage-dependent calcium channel gamma-7 subunit", "tax_id": 10090, "disease": "", "pathway": " (mmu:81904); (R-MMU-5576892); (R-MMU-5576893)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "11738816;11927536;17475805;20529126;21172611;21183079;23872597;25583485", "class_list": "", "function": "Gamma-7 is a new member of the transmembrane AMPA receptor regulatory protein (TARP) family that can differentially influence AMPA receptors in cerebellar neurons. (TARP gamma-7), [RefSeq, PubMed]; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization (By similarity). Shows specificity only for GRIA1 and GRIA2 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Results suggest that TARPs gamma-2 and gamma-7 cooperatively promote synaptic expression of cerebellar AMPA receptors, and the latter also promotes glial expression., [RefSeq, PubMed]; TARP gamma-7 causes AMPA receptors to 'resensitize' upon continued glutamate application., [RefSeq, PubMed]; The results of this study suggested that TARPed synaptic receptors in granule cells require both gamma-2 and gamma-7 and reveal an unexpected basis for the loss of AMPAR-mediated transmission in stargazer mice., [RefSeq, PubMed]; Thus, gamma-7 is capable of supporting a component of excitatory transmission in PCs, sufficient to maintain essentially normal motor behavior, in the absence of gamma-2., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VBX3;Q8WXS6;Q9BXT1", "ec_number_list": [], "go_molecular_function": "GO:0005246 calcium channel regulator activity;GO:0005245 voltage-gated calcium channel activity;GO:0016247 channel regulator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0043025 neuronal cell body;GO:0032281 AMPA glutamate receptor complex", "go_biological_process": "GO:1903861 positive regulation of dendrite extension;GO:0043488 regulation of mRNA stability;GO:0051968 positive regulation of synaptic transmission, glutamatergic;GO:0019226 transmission of nerve impulse;GO:2000311 regulation of AMPA receptor activity", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P62956-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P98191-1", "uniprot_id": [ { "id": "CDS1_MOUSE", "url": "https://www.uniprot.org/uniprot/P98191", "type": "external" } ], "mass": 52875.0, "length": 461, "protein_name": "Phosphatidate cytidylyltransferase 1", "gene_name": "Cds1", "organism": "Mouse", "refseq_name": "phosphatidate cytidylyltransferase 1 isoform a", "refseq_ac": [ { "id": "NP_775546", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775546", "type": "external" } ], "gene_names_uniprotkb": "Cds1; Cds", "gene_names_refseq": "4833409J18Rik; Cds1", "protein_names_uniprotkb": "Phosphatidate cytidylyltransferase 1; 2.7.7.41; CDP-DAG synthase 1; CDP-DG synthase 1; CDP-diacylglycerol synthase 1; CDP-diglyceride pyrophosphorylase 1; CDP-diglyceride synthase 1; CDS 1; CTP:phosphatidate cytidylyltransferase 1", "protein_names_refseq": "CDP-DAG synthase 1; CDP-DG synthase 1; CDP-diglyceride pyrophosphorylase 1; CDP-diglyceride synthase 1; CDS 1; CTP:phosphatidate cytidylyltransferase 1; phosphatidate cytidylyltransferase 1 isoform a; phosphatidate cytidylyltransferase 1", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:74596); (R-MMU-1483226)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "16023307;21183079;21540332;22105363;22645316;24129315;26946540;31599954;34428180;9889000", "class_list": "", "function": "Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol (By similarity). Exhibits almost no acyl chain preference for PA, showing no discrimination for the sn-1/sn-2 acyl chain composition of PAs (By similarity). Plays an important role in regulating the growth of lipid droplets which are storage organelles at the center of lipid and energy homeostasis (PubMed:26946540). Positively regulates the differentiation and development of adipocytes (PubMed:26946540)., [UniProtKB, PubMed, UniProtKB]; Cds1 showed a very restricted expression pattern and was mapped to chromosome 5E3., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CGZ1", "ec_number_list": [ { "id": "2.7.7.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.41", "type": "external" } ], "go_molecular_function": "GO:0004605 phosphatidate cytidylyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0045600 positive regulation of fat cell differentiation;GO:0006661 phosphatidylinositol biosynthetic process;GO:0140042 lipid droplet formation;GO:0016024 CDP-diacylglycerol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P98191-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56395-1", "uniprot_id": [ { "id": "CYB5_MOUSE", "url": "https://www.uniprot.org/uniprot/P56395", "type": "external" } ], "mass": 15241.0, "length": 134, "protein_name": "Cytochrome b5", "gene_name": "Cyb5a", "organism": "Mouse", "refseq_name": "cytochrome b5 isoform 1", "refseq_ac": [ { "id": "NP_080073", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080073", "type": "external" } ], "gene_names_uniprotkb": "Cyb5a; Cyb5", "gene_names_refseq": "0610009N12Rik; Cyb5a; Cyb5", "protein_names_uniprotkb": "Cytochrome b5", "protein_names_refseq": "cytochrome b5 isoform 1", "tax_id": 10090, "disease": "methemoglobinemia and ambiguous genitalia (Disease Ontology:DOID:0112316); methemoglobinemia (Disease Ontology:DOID:10783); pyelonephritis (Disease Ontology:DOID:11400); stomatitis (Disease Ontology:DOID:9637)", "pathway": " (mmu:109672); (R-MMU-196836); (R-MMU-9609523)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "21750661;22792238;23576753;23806337;26974035;30084848;34428180;36288343;37453647;37507081", "class_list": "", "function": "Cytochrome b5 and cytokeratin 17 are biomarkers in bronchoalveolar fluid signifying onset of acute lung injury., [RefSeq, PubMed]; Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases. It is also involved in several steps of the sterol biosynthesis pathway, particularly in the C-5 double bond introduction during the C-5 desaturation., [UniProtKB]; Demonstration of the physiologic importance of cytochrome b5 activating the 17,20-lyase reaction and the production of 19-carbon sex steroids from 21-carbon precursors in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0046872 metal ion binding;GO:0004768 stearoyl-CoA 9-desaturase activity;GO:0020037 heme binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006631 fatty acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P56395-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48771-1", "uniprot_id": [ { "id": "CX7A2_MOUSE", "url": "https://www.uniprot.org/uniprot/P48771", "type": "external" } ], "mass": 9291.0, "length": 83, "protein_name": "Cytochrome c oxidase subunit 7A2, mitochondrial", "gene_name": "Cox7a2", "organism": "Mouse", "refseq_name": "cytochrome c oxidase subunit 7A2, mitochondrial precursor", "refseq_ac": [ { "id": "NP_034075", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034075", "type": "external" } ], "gene_names_uniprotkb": "Cox7a2; Cox7a3; Cox7al", "gene_names_refseq": "COX7AL; Cox7a2; Cox7a3; CoxVIIa-L", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 7A2, mitochondrial; Cytochrome c oxidase subunit VIIa-L; Cytochrome c oxidase subunit VIIa-liver/heart", "protein_names_refseq": "cytochrome c oxidase subunit 7A2, mitochondrial precursor; cytochrome c oxidase subunit 7A2, mitochondrial; cytochrome c oxidase subunit VIIa 2; cytochrome c oxidase subunit VIIa 3; cytochrome c oxidase subunit VIIa-L; cytochrome c oxidase subunit VIIa-liver/heart", "tax_id": 10090, "disease": "", "pathway": " (mmu:12866); (R-MMU-5628897); (R-MMU-611105); (R-MMU-9707564); (R-MMU-9864848)", "pathway_count": 5, "publication_count": 12, "publication_id_list": "12853116;16393994;1659684;16752004;21548202;23576753;25605945;31219806;31361958;34428180;36288343;38575788", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation (PubMed:38575788). The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase (PubMed:38575788). Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water (By similarity). Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)) (By similarity). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix (By similarity)., [UniProtKB, UniProtKB, PubMed]; Cox7a2 decreased P70S6K phosphorylation, reduced StAR expression and consequently inhibited LH-induced testosterone biosynthesis in the TM3 Leydig cells., [RefSeq, PubMed]; Cox7a2 inhibited lutropin-induced StAR protein expression, and consequent testosterone production, [RefSeq, PubMed]; The protein level for COX7AL was decreased early during the acute phase., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O54969;Q545J7", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0045277 respiratory chain complex IV;GO:0098803 respiratory chain complex", "go_biological_process": "GO:0006123 mitochondrial electron transport, cytochrome c to oxygen;GO:0006119 oxidative phosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P48771-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60867-1", "uniprot_id": [ { "id": "NDF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60867", "type": "external" } ], "mass": 39999.0, "length": 357, "protein_name": "Neurogenic differentiation factor 1", "gene_name": "Neurod1", "organism": "Mouse", "refseq_name": "neurogenic differentiation factor 1", "refseq_ac": [ { "id": "NP_035024", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035024", "type": "external" } ], "gene_names_uniprotkb": "Neurod1; Neurod", "gene_names_refseq": "BETA2; BHF-1; Nd1; Neurod1; Neurod; bHLHa3", "protein_names_uniprotkb": "Neurogenic differentiation factor 1; Beta-cell E-box transcriptional activator 2; Beta2; NeuroD1", "protein_names_refseq": "beta-cell E-box transcriptional activator 2; neurogenic differentiation factor 1", "tax_id": 10090, "disease": "type 1 diabetes mellitus 7 (Disease Ontology:DOID:0110746); maturity-onset diabetes of the young type 6 (Disease Ontology:DOID:0111104); glucose intolerance (Disease Ontology:DOID:10603); hyperglycemia (Disease Ontology:DOID:4195); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:18012)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "10398678;10639171;11152640;11861467;11970861;12297313;12810726;14697366;14752053;15797719;17403669;18007592;18069799;18339630;18560595;19200230;19759004;19854889;21593321;23395635;31219806;32606250;7754368;9308961;9512516", "class_list": "", "function": "Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q545N9;Q60897", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0046982 protein heterodimerization activity;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006913 nucleocytoplasmic transport;GO:0032024 positive regulation of insulin secretion;GO:0043065 positive regulation of apoptotic process;GO:0045666 positive regulation of neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q60867-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q69ZA1-1", "uniprot_id": [ { "id": "CDK13_MOUSE", "url": "https://www.uniprot.org/uniprot/Q69ZA1", "type": "external" } ], "mass": 164553.0, "length": 1511, "protein_name": "Cyclin-dependent kinase 13", "gene_name": "Cdk13", "organism": "Mouse", "refseq_name": "cyclin-dependent kinase 13 isoform 1", "refseq_ac": [ { "id": "NP_001074527", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074527", "type": "external" } ], "gene_names_uniprotkb": "Cdk13; Cdc2l5; Kiaa1791", "gene_names_refseq": "2310015O17Rik; Cdc2l5; Cdk13", "protein_names_uniprotkb": "Cyclin-dependent kinase 13; 2.7.11.22; 2.7.11.23; CDC2-related protein kinase 5; Cell division cycle 2-like protein kinase 5; Cell division protein kinase 13", "protein_names_refseq": "CDC2-related protein kinase 5; cell division cycle 2-like 5 (cholinesterase-related cell division controller); cell division cycle 2-like protein kinase 5; cell division protein kinase 13; cyclin-dependent kinase 13 isoform 1", "tax_id": 10090, "disease": "congenital heart defects, dysmorphic facial features, and intellectual developmental disorder (Disease Ontology:DOID:0112247); prostate cancer (Disease Ontology:DOID:10283); prostate carcinoma (Disease Ontology:DOID:10286); intellectual disability (Disease Ontology:DOID:1059); breast cancer (Disease Ontology:DOID:1612); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:69562); (R-MMU-6796648); (R-MMU-6798695)", "pathway_count": 3, "publication_count": 21, "publication_id_list": "17242355;17261272;21183079;21606357;21750661;22012619;22517741;22645316;24999027;25428506;25605945;29237092;30059200;30779550;32782141;32848054;34428180;35857807;36852467;40885482;40997131", "class_list": "", "function": "Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis., [UniProtKB, PubMed]; Dual Inhibition of CDK12/CDK13 Targets Both Tumor and Immune Cells in Ovarian Cancer., [RefSeq, PubMed]; The findings of this study suggest that Cdk12 and Cdk13 regulate axonal elongation through a common signaling pathway that modulates Cdk5 expression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 15, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 15, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 15, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 15, "binding_glycan_count": 0, "secondary_ac_list": "E9QKZ6;Q80V11;Q8BZG1;Q8K0A4", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" 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{ "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { 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"external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "5.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity;GO:0030332 cyclin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0019908 nuclear cyclin-dependent protein kinase holoenzyme complex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0030097 hemopoiesis;GO:0009966 regulation of signal transduction;GO:0032968 positive regulation of transcription elongation by RNA polymerase II;GO:0000380 alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "Q69ZA1-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61687-1", "uniprot_id": [ { "id": "ATRX_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61687", "type": "external" } ], "mass": 278587.0, "length": 2476, "protein_name": "Chromatin remodeler ATRX", "gene_name": "Atrx", "organism": "Mouse", "refseq_name": "transcriptional regulator ATRX", "refseq_ac": [ { "id": "NP_033556", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033556", "type": "external" } ], "gene_names_uniprotkb": "Atrx; Hp1bp2; Xnp", "gene_names_refseq": "4833408C14Rik; ATR2; Atrx; DXHXS6677E; HP1-BP38; Hp1bp2; Hp1bp38; MRXS3; RAD54L; Rad54; XH2; Xnp; ZNF-HX", "protein_names_uniprotkb": "Chromatin remodeler ATRX; 3.6.4.-; HP1 alpha-interacting protein; HP1-BP38 protein; Heterochromatin protein 2; Transcriptional regulator ATRX; X-linked nuclear protein", "protein_names_refseq": "ATP-dependent helicase ATRX; HP1 alpha-interacting protein; X-linked nuclear protein; heterochromatin protein 2; transcriptional regulator ATRX", "tax_id": 10090, "disease": "X-linked intellectual disability-hypotonic facies syndrome-1 (Disease Ontology:DOID:0080982); alpha thalassemia-X-linked intellectual disability syndrome (Disease Ontology:DOID:0110030); alpha-thalassemia myelodysplasia syndrome (Disease Ontology:DOID:0112125); intellectual disability (Disease Ontology:DOID:1059); sarcoma (Disease Ontology:DOID:1115); islet cell tumor (Disease Ontology:DOID:1799); melanoma (Disease Ontology:DOID:1909); glioblastoma (Disease Ontology:DOID:3068); malignant astrocytoma (Disease Ontology:DOID:3069); high grade glioma (Disease Ontology:DOID:3070); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung adenocarcinoma (Disease Ontology:DOID:3910); lung small cell carcinoma (Disease Ontology:DOID:5409)", "pathway": " (mmu:22589); (R-MMU-9670095)", "pathway_count": 2, "publication_count": 27, "publication_id_list": "10.1101/2023.09.13.557529;10570185;17242355;17296936;19131326;19144319;20110566;20159591;20211137;20504901;21029860;21183079;21666677;21750661;24129315;24463520;24651726;25428506;25605945;28528544;30084848;31219806;31599954;34428180;36852467;8978696;9545503", "class_list": "", "function": "Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells probably implying recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according (PubMed:20211137) is required for its transcriptional repression in embryonic stem cells. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCF within the H19 imprinting control region (ICR) and involved in establishment of histone tails modifications in the ICR. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 43, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 13, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A2ADH4", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016887 ATP hydrolysis activity;GO:0031490 chromatin DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0016605 PML body;GO:0000228 nuclear chromosome", "go_biological_process": "GO:0031509 subtelomeric heterochromatin formation;GO:0006281 DNA repair;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "Q61687-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88398-1", "uniprot_id": [ { "id": "AVIL_MOUSE", "url": "https://www.uniprot.org/uniprot/O88398", "type": "external" } ], "mass": 92032.0, "length": 819, "protein_name": "Advillin", "gene_name": "Avil", "organism": "Mouse", "refseq_name": "advillin", "refseq_ac": [ { "id": "NP_033765", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033765", "type": "external" } ], "gene_names_uniprotkb": "Avil; Advil", "gene_names_refseq": "Advil; Avil; DOC6", "protein_names_uniprotkb": "Advillin; Actin-binding protein DOC6; p92", "protein_names_refseq": "actin-binding protein DOC6; advillin; p92", "tax_id": 10090, "disease": "nephrotic syndrome type 21 (Disease Ontology:DOID:0112267)", "pathway": " (mmu:11567)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15247299;17947660;18160648;21750661;25428506;9649432;9664034", "class_list": "", "function": "Ca(2+)-regulated actin-binding protein which plays an important role in actin bundling. May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis (PubMed:15247299, PubMed:18160648). In podocytes, controls lamellipodia formation through the regulation of EGF-induced diacylglycerol generation by PLCE1 and ARP2/3 complex assembly (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; Interaction of SREC-I and advillin are involved in the development of dorsal root ganglion neurons by inducing the described morphological changes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O70466;Q3U1K5", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0051015 actin filament binding;GO:0071933 Arp2/3 complex binding", "go_cellular_component": "GO:0005884 actin filament;GO:0005925 focal adhesion;GO:0015629 actin cytoskeleton;GO:0030027 lamellipodium;GO:0030424 axon", "go_biological_process": "GO:0007015 actin filament organization;GO:0007399 nervous system development;GO:0010976 positive regulation of neuron projection development;GO:0051016 barbed-end actin filament capping;GO:0008154 actin polymerization or depolymerization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O88398-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q641K1-1", "uniprot_id": [ { "id": "CBPC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q641K1", "type": "external" } ], "mass": 137197.0, "length": 1218, "protein_name": "Cytosolic carboxypeptidase 1", "gene_name": "Agtpbp1", "organism": "Mouse", "refseq_name": "cytosolic carboxypeptidase 1 isoform 2", "refseq_ac": [ { "id": "NP_001041473", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041473", "type": "external" } ], "gene_names_uniprotkb": "Agtpbp1; Ccp1; Nna1", "gene_names_refseq": "1700020N17Rik; 2310001G17Rik; 2900054O13Rik; 4930445M19Rik; 5730402G09Rik; Agtpbp1; CCP1; Nna1; atms; nmf243; pcd", "protein_names_uniprotkb": "Cytosolic carboxypeptidase 1; 3.4.17.-; 3.4.17.24; ATP/GTP-binding protein 1; Nervous system nuclear protein induced by axotomy protein 1; Protein deglutamylase CCP1", "protein_names_refseq": "Purkinje cell degeneration; cytosolic carboxypeptidase 1 isoform 2; cytosolic carboxypeptidase 1; nervous system nuclear protein induced by axotomy protein 1; nuclear ATP/GTP-binding protein; protein deglutamylase CCP1", "tax_id": 10090, "disease": "retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (mmu:67269)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "11083920;11884758;16465590;16942761;16952463;18602413;20620870;20920790;21074048;21750661;22170066;25103237;29593216;30420557;34428180;36982413;37937809", "class_list": "", "function": "CCP1, a Regulator of Tubulin Post-Translational Modifications, Potentially Plays an Essential Role in Cerebellar Development. Publication Status: Online-Only, [RefSeq, PubMed]; Deleterious genetic changes in AGTPBP1 result in teratozoospermia with sperm head and flagella defects., [RefSeq, PubMed]; Metallocarboxypeptidase that mediates protein deglutamylation of tubulin and non-tubulin target proteins (PubMed:21074048, PubMed:22170066, PubMed:25103237, PubMed:29593216, PubMed:30420557). Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin (PubMed:22170066, PubMed:25103237, PubMed:30420557). Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate (PubMed:21074048). Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of alpha-tubulin as well as non-tubulin proteins such as MYLK (PubMed:21074048, PubMed:22170066). Involved in KLF4 deglutamylation which promotes KLF4 proteasome-mediated degradation, thereby negatively regulating cell pluripotency maintenance and embryogenesis (PubMed:29593216)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TDS0;Q3V147;Q6P9R9;Q8C1K8;Q9D962;Q9EQI4", "ec_number_list": [ { "id": "3.4.17.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.-", "type": "external" }, { "id": "3.4.17.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.24", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004181 metallocarboxypeptidase activity;GO:0008233 peptidase activity;GO:0015631 tubulin binding;GO:0008237 metallopeptidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0008285 negative regulation of cell population proliferation;GO:0050905 neuromuscular process;GO:0060041 retina development in camera-type eye;GO:0007628 adult walking behavior", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q641K1-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CCN5-1", "uniprot_id": [ { "id": "BCAS3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CCN5", "type": "external" } ], "mass": 101021.0, "length": 928, "protein_name": "BCAS3 microtubule associated cell migration factor", "gene_name": "Bcas3", "organism": "Mouse", "refseq_name": "BCAS3 microtubule associated cell migration factor isoform b", "refseq_ac": [ { "id": "NP_001160114", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160114", "type": "external" } ], "gene_names_uniprotkb": "Bcas3", "gene_names_refseq": "1500019F07Rik; 2610028P08Rik; Bcas3; K20D4; Phaf2; rudhira", "protein_names_uniprotkb": "BCAS3 microtubule associated cell migration factor; Breast carcinoma-amplified sequence 3 homolog; K20D4; Protein rudhira", "protein_names_refseq": "BCAS3 microtubule associated cell migration factor isoform b; breast carcinoma amplified sequence 3; breast carcinoma-amplified sequence 3 homolog; protein rudhira", "tax_id": 10090, "disease": "Hengel-Maroofian-Schols syndrome (Disease Ontology:DOID:0070408); breast cancer (Disease Ontology:DOID:1612)", "pathway": " (mmu:192197)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;16099728;16617102;17242355;17505058;21183079;21750661;22300583;22645316;25605945;31219806;34428180;40885482", "class_list": "", "function": "Expressed at high levels in embryonic stem cells and is restricted to blood islands and the erythroid lineage during embryonic development, [RefSeq, PubMed]; Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin (By similarity). Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation. Plays a regulatory role in autophagic activity. In complex with PHAF1, associates with the preautophagosomal structure during both non-selective and selective autophagy. Probably binds phosphatidylinositol 3-phosphate (PtdIns3P) which would mediate the recruitment preautophagosomal structures (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q8CC16;Q9EPX3", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0005096 GTPase activator activity;GO:0042393 histone binding;GO:0048487 beta-tubulin binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031252 cell leading edge;GO:0071944 cell periphery;GO:0045111 intermediate filament cytoskeleton", "go_biological_process": "GO:0001525 angiogenesis;GO:0006351 DNA-templated transcription;GO:0007267 cell-cell signaling;GO:0032956 regulation of actin cytoskeleton organization;GO:0042594 response to starvation", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q8CCN5-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O89093-1", "uniprot_id": [ { "id": "CCL20_MOUSE", "url": "https://www.uniprot.org/uniprot/O89093", "type": "external" } ], "mass": 10826.0, "length": 97, "protein_name": "C-C motif chemokine 20", "gene_name": "Ccl20", "organism": "Mouse", "refseq_name": "C-C motif chemokine 20 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001153210", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153210", "type": "external" } ], "gene_names_uniprotkb": "Ccl20; Larc; Scya20", "gene_names_refseq": "CKb4; Ccl20; LARC; MIP-3A; MIP-3[a]; MIP3A; ST38; Scya20; exodus-1", "protein_names_uniprotkb": "C-C motif chemokine 20; Beta-chemokine exodus-1; CC chemokine LARC; CC chemokine ST38; Liver and activation-regulated chemokine; MIP-3-alpha; Macrophage inflammatory protein 3 alpha; Small-inducible cytokine A20", "protein_names_refseq": "C-C motif chemokine 20 isoform 2 precursor; C-C motif chemokine 20; CC chemokine LARC; CC chemokine ST38; MIP-3-alpha; beta-chemokine exodus-1; chemokine (C-C motif) ligand 20; liver and activation-regulated chemokine; macrophage inflammatory protein 3 alpha; small inducible cytokine subfamily A20; small-inducible cytokine A20", "tax_id": 10090, "disease": "exanthem (Disease Ontology:DOID:0050486); primary cutaneous T-cell non-Hodgkin lymphoma (Disease Ontology:DOID:0060061); anogenital venereal wart (Disease Ontology:DOID:11168); Lyme disease (Disease Ontology:DOID:11729); fungal infectious disease (Disease Ontology:DOID:1564); pancreatic cancer (Disease Ontology:DOID:1793); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); acrodermatitis (Disease Ontology:DOID:2722); asthma (Disease Ontology:DOID:2841); IgA glomerulonephritis (Disease Ontology:DOID:2986); skin papilloma (Disease Ontology:DOID:3178); atopic dermatitis (Disease Ontology:DOID:3310); systemic scleroderma (Disease Ontology:DOID:418); ulcerative colitis (Disease Ontology:DOID:8577); psoriasis (Disease Ontology:DOID:8893)", "pathway": " (mmu:20297); (R-MMU-380108); (R-MMU-418594)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10064080;11373289;19050256;20068036;21376174;21750661;24638065;25122636;26495903;37641931;38594728;9862452;9916893", "class_list": "", "function": "Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:20068036, PubMed:9862452). The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and autoimmune diseases (PubMed:21376174). CCL20 acts as a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes (By similarity). Involved in the recruitment of both the pro-inflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation (PubMed:19050256). Required for optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells (PubMed:24638065). Positively regulates sperm motility and chemotaxis via its binding to CCR6 which triggers Ca2+ mobilization in the sperm which is important for its motility (PubMed:25122636). May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells (PubMed:10064080)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Atg5 deficiency in macrophages protects against kidney fibrosis via the CCR6-CCL20 axis. Publication Status: Online-Only, [RefSeq, PubMed]; Neutrophils for Revascularization Require Activation of CCR6 and CCL20 by TNFalpha., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9Z1X3", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0008009 chemokine activity;GO:0031731 CCR6 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0032730 positive regulation of interleukin-1 alpha production;GO:0006935 chemotaxis;GO:0006954 inflammatory response;GO:0019722 calcium-mediated signaling;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "O89093-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99L43-1", "uniprot_id": [ { "id": "CDS2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99L43", "type": "external" } ], "mass": 51314.0, "length": 444, "protein_name": "Phosphatidate cytidylyltransferase 2", "gene_name": "Cds2", "organism": "Mouse", "refseq_name": "phosphatidate cytidylyltransferase 2 isoform b", "refseq_ac": [ { "id": "NP_001277968", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277968", "type": "external" } ], "gene_names_uniprotkb": "Cds2", "gene_names_refseq": "5730450N06Rik; 5730460C18Rik; Cds2; D2Wsu127e", "protein_names_uniprotkb": "Phosphatidate cytidylyltransferase 2; 2.7.7.41; CDP-DAG synthase 2; CDP-DG synthase 2; CDP-diacylglycerol synthase 2; CDP-diglyceride pyrophosphorylase 2; CDP-diglyceride synthase 2; CDS 2; CTP:phosphatidate cytidylyltransferase 2", "protein_names_refseq": "CDP-DAG synthase 2; CDP-DG synthase 2; CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2; CDP-diglyceride pyrophosphorylase 2; CDP-diglyceride synthase 2; CTP:phosphatidate cytidylyltransferase 2; phosphatidate cytidylyltransferase 2 isoform b; phosphatidate cytidylyltransferase 2", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:110911); (R-MMU-1483148)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;16023307;17208939;17242355;18630941;19144319;21183079;21750661;26946540;30899004;31219806;31501519;33300544;34428180;36546079", "class_list": "", "function": "Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]; Cds2 showed a ubiquitous pattern of expression and was mapped to chromosome 2G1., [RefSeq, PubMed]; Endothelial CDS2 deficiency causes VEGFA-mediated vascular regression and tumor inhibition., [RefSeq, PubMed]; Hepatic CDP-diacylglycerol synthase 2 deficiency causes mitochondrial dysfunction and promotes rapid progression of NASH and fibrosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TMD1;Q6NSU1", "ec_number_list": [ { "id": "2.7.7.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.41", "type": "external" } ], "go_molecular_function": "GO:0004605 phosphatidate cytidylyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007602 phototransduction;GO:0140042 lipid droplet formation;GO:0016024 CDP-diacylglycerol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q99L43-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02463-1", "uniprot_id": [ { "id": "CO4A1_MOUSE", "url": "https://www.uniprot.org/uniprot/P02463", "type": "external" } ], "mass": 160679.0, "length": 1669, "protein_name": "Collagen alpha-1(IV) chain", "gene_name": "Col4a1", "organism": "Mouse", "refseq_name": "collagen alpha-1(IV) chain precursor", "refseq_ac": [ { "id": "NP_034061", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034061", "type": "external" } ], "gene_names_uniprotkb": "Col4a1", "gene_names_refseq": "Bru; Col4a-1; Col4a1; Raw; Svc", "protein_names_uniprotkb": "Collagen alpha-1(IV) chain", "protein_names_refseq": "alpha-1 type IV collagen; alpha1(IV) collagen; collagen alpha-1(IV) chain precursor; collagen alpha-1(IV) chain; procollagen, type IV, alpha 1", "tax_id": 10090, "disease": "Walker-Warburg syndrome (Disease Ontology:DOID:0050560); stroke (Disease Ontology:DOID:0051061); porencephaly (Disease Ontology:DOID:0060263); brain small vessel disease 1 (Disease Ontology:DOID:0090125); retinal arterial tortuosity (Disease Ontology:DOID:0111547); uterine fibroid (Disease Ontology:DOID:13223); kidney disease (Disease Ontology:DOID:557); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:12826); (R-MMU-1442490); (R-MMU-1566977); (R-MMU-1650814); (R-MMU-186797); (R-MMU-2022090); (R-MMU-216083); (R-MMU-2243919); (R-MMU-3000157); (R-MMU-3000171); (R-MMU-419037)", "pathway_count": 11, "publication_count": 17, "publication_id_list": "15905400;17324935;21750661;22842973;24368846;25645914;2578961;2703490;2842328;28424209;3009468;3198626;3200851;3338568;3379041;3597383;3755692", "class_list": "", "function": "Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation., [UniProtKB, UniProtKB]; This gene encodes the alpha-1 subunit of the type IV collagens, an essential component of basement membranes. The encoded protein forms a triple helical heterotrimer comprised of two alpha-1 and one alpha-2 subunits that assembles into a type IV collagen network. This gene is located adjacent to the gene encoding alpha-2 subunit. Mice lacking both the alpha-1 and alpha-2 subunits of collagen IV die in utero due to structural deficiencies in the basement membranes and certain mutations in this gene cause perinatal cerebral hemorrhage and porencephaly. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2015]., [RefSeq]; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 16, "predicted_n_glycosites": 1, "predicted_o_glycosites": 15, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 16, "binding_glycan_count": 0, "secondary_ac_list": "Q3UHJ4;Q3UJE7;Q3UQV2;Q53X35;Q6GQS7;Q6PHB5;Q99LQ8", "ec_number_list": [], "go_molecular_function": "GO:0005201 extracellular matrix structural constituent;GO:0030020 extracellular matrix structural constituent conferring tensile strength;GO:0048407 platelet-derived growth factor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0005604 basement membrane;GO:0005587 collagen type IV trimer", "go_biological_process": "GO:0007528 neuromuscular junction development;GO:0030198 extracellular matrix organization;GO:0030855 epithelial cell differentiation;GO:0007420 brain development;GO:0030199 collagen fibril organization", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P02463-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6EDY6-1", "uniprot_id": [ { "id": "CARL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6EDY6", "type": "external" } ], "mass": 151860.0, "length": 1374, "protein_name": "F-actin-uncapping protein LRRC16A", "gene_name": "Carmil1", "organism": "Mouse", "refseq_name": "F-actin-uncapping protein LRRC16A isoform 1", "refseq_ac": [ { "id": "NP_081101", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081101", "type": "external" } ], "gene_names_uniprotkb": "Carmil1; Carmil; Lrrc16a; Lrrc16", "gene_names_refseq": "1110037D04Rik; CARMIL; CARML1; Carmil1; D130057M20; Lrrc16a; Lrrc16", "protein_names_uniprotkb": "F-actin-uncapping protein LRRC16A; CARMIL homolog; CARML1; Capping protein regulator and myosin 1 linker protein 1; Capping protein, Arp2/3 and myosin-I linker homolog 1; Capping protein, Arp2/3 and myosin-I linker protein 1; Leucine-rich repeat-containing protein 16A", "protein_names_refseq": "CARMIL homolog; F-actin-uncapping protein LRRC16A isoform 1; F-actin-uncapping protein LRRC16A; capping protein regulator and myosin 1 linker protein 1; capping protein, Arp2/3 and myosin-I linker homolog 1; capping protein, Arp2/3 and myosin-I linker protein 1; leucine rich repeat containing 16A; leucine rich repeat containing 16; leucine-rich repeat-containing protein 16A", "tax_id": 10090, "disease": "", "pathway": " (mmu:68732)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;16054028;16452087;19926785;21183079;21750661;24778263;25395583;36583994", "class_list": "", "function": "Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028). Plays a role in lamellipodial protrusion formations and cell migration (PubMed:16054028)., [UniProtKB, PubMed]; Expression of the capping-protein-binding region of CARMIL (also known as LRRC16A) impaired spindle migration and polar body extrusion during oocyte maturation and decreased the density of the cytoplasmic actin mesh, [RefSeq, PubMed]; MCARMIL is a key regulator of CP and has profound effects on cell behavior., [RefSeq, PubMed]; Our data argue that a large pool of freely diffusing, inactive capping protein (CP:V-1) feeds, via CARMIL-driven complex exchange, the formation of weak-capping complexes (CP:CARMIL) at the plasma membrane of protruding edges., [RefSeq, PubMed]; The isolated CAH3 domain of CARMIL (and presumably the intact molecule as well) possesses the ability to uncap CP-capped actin filaments, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9606, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q5NCM0;Q8BQ45;Q8BRS5;Q91YZ6", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016607 nuclear speck;GO:0030027 lamellipodium", "go_biological_process": "GO:0016477 cell migration;GO:0030335 positive regulation of cell migration;GO:0046415 urate metabolic process;GO:0051496 positive regulation of stress fiber assembly;GO:0030032 lamellipodium assembly", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q6EDY6-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88379-1", "uniprot_id": [ { "id": "BAZ1A_MOUSE", "url": "https://www.uniprot.org/uniprot/O88379", "type": "external" } ], "mass": 178459.0, "length": 1555, "protein_name": "Bromodomain adjacent to zinc finger domain protein 1A", "gene_name": "Baz1a", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Baz1a; Cbp146", "gene_names_refseq": "", "protein_names_uniprotkb": "Bromodomain adjacent to zinc finger domain protein 1A; Cbp146", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:217578)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12434153;19144319;21183079;21750661;34105348;34428180;34887587;35820727;39627609;9701556", "class_list": "", "function": "Regulatory subunit of the ATP-dependent ACF-1 and ACF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and slide edge- and center-positioned histone octamers away from their original location on the DNA template to facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (By similarity). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (By similarity). The ACF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the ACF-5 ISWI chromatin remodeling complex (By similarity). Has a role in sensing the length of DNA which flank nucleosomes, which modulates the nucleosome spacing activity of the ACF-5 ISWI chromatin remodeling complex (By similarity). Involved in DNA replication and together with SMARCA5/SNF2H is required for replication of pericentric heterochromatin in S-phase (By similarity). May have a role in nuclear receptor-mediated transcription repression (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TKK7;Q3UXF6", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000228 nuclear chromosome;GO:0005721 pericentric heterochromatin;GO:0008623 CHRAC;GO:0016590 ACF complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0006275 regulation of DNA replication;GO:0006334 nucleosome assembly", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "O88379-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6XVS9-1", "uniprot_id": [ { "id": "F6XVS9_MOUSE", "url": "https://www.uniprot.org/uniprot/F6XVS9", "type": "external" } ], "mass": 23673.0, "length": 199, "protein_name": "Spermatogenesis associated glutamate (E)-rich protein 1N", "gene_name": "Speer1n", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Speer1n", "gene_names_refseq": "", "protein_names_uniprotkb": "Spermatogenesis associated glutamate (E)-rich protein 1N", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F6XVS9-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80YR7-1", "uniprot_id": [ { "id": "CLSPN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80YR7", "type": "external" } ], "mass": 146715.0, "length": 1315, "protein_name": "Claspin", "gene_name": "Clspn", "organism": "Mouse", "refseq_name": "claspin isoform 4", "refseq_ac": [ { "id": "NP_780763", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780763", "type": "external" } ], "gene_names_uniprotkb": "Clspn", "gene_names_refseq": "B130025E01; Clspn; E130314M08Rik", "protein_names_uniprotkb": "Claspin", "protein_names_refseq": "claspin homolog; claspin isoform 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:269582); (R-MMU-111465); (R-MMU-176187); (R-MMU-5689880); (R-MMU-5693607)", "pathway_count": 5, "publication_count": 12, "publication_id_list": "19144319;20081369;21183079;21750661;22872234;25428506;25605945;27401717;30084848;30779550;31219806;34428180", "class_list": "", "function": "Rad9A-mediated Claspin localization is a vital step during checkpoint activation., [RefSeq, PubMed]; Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation (PubMed:27401717). Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins (By similarity). Also required to maintain normal rates of replication fork progression during unperturbed DNA replication (PubMed:27401717). Binds directly to DNA, with particular affinity for branched or forked molecules and interacts with multiple protein components of the replisome such as the MCM2-7 complex and TIMELESS. Important for initiation of DNA replication, recruits kinase CDC7 to phosphorylate MCM2-7 components (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 29, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1ARX6;Q69GM2", "ec_number_list": [], "go_molecular_function": "GO:0010997 anaphase-promoting complex binding;GO:0000217 DNA secondary structure binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0000076 DNA replication checkpoint signaling;GO:0006281 DNA repair;GO:0000077 DNA damage checkpoint signaling;GO:0007095 mitotic G2 DNA damage checkpoint signaling;GO:0033314 mitotic DNA replication checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q80YR7-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DAW9-1", "uniprot_id": [ { "id": "CNN3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DAW9", "type": "external" } ], "mass": 36429.0, "length": 330, "protein_name": "Calponin-3", "gene_name": "Cnn3", "organism": "Mouse", "refseq_name": "calponin-3", "refseq_ac": [ { "id": "NP_082320", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082320", "type": "external" } ], "gene_names_uniprotkb": "Cnn3", "gene_names_refseq": "1600014M03Rik; Calpo3; Cnn3", "protein_names_uniprotkb": "Calponin-3; Calponin, acidic isoform", "protein_names_refseq": "calponin-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:71994)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;17242355;21750661;22645316;23276748;23806337;25153642;25428506;28135057;28528544;29151265;31219806;31992794;40021952", "class_list": "", "function": "Provides evidence for an important role of Cnn3 during development of the embryonic brain and in regulating NSC function, [RefSeq, PubMed]; These results reveal that CNN3 plays a crucial role in regulating lens epithelial contractile activity and provide supporting evidence that CNN-3 deficiency is associated with the induction of epithelial plasticity, fibrogenic activity and mechanosensitive Yap/Taz (Wwtr1) transcriptional activation. Publication Status: Online-Only, [RefSeq, PubMed]; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. 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"missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3YXJ5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3YZZ2-1", "uniprot_id": [ { "id": "TGR3L_MOUSE", "url": "https://www.uniprot.org/uniprot/D3YZZ2", "type": "external" } ], "mass": 31076.0, "length": 297, "protein_name": "Transforming growth factor-beta receptor type 3-like protein", "gene_name": "Tgfbr3l", "organism": "Mouse", "refseq_name": "transforming growth factor-beta receptor type 3-like protein precursor", "refseq_ac": [ { "id": "NP_001182187", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001182187", "type": "external" } ], "gene_names_uniprotkb": "Tgfbr3l; Gm14378", "gene_names_refseq": "Gm14378; TGFR-3L; Tgfbr3l", "protein_names_uniprotkb": "Transforming growth factor-beta receptor type 3-like protein; TGF-beta receptor type-3-like protein; TGFR-3L; Transforming growth factor, beta receptor III-like", "protein_names_refseq": "TGF-beta receptor type-3-like protein; transforming growth factor-beta receptor type 3-like protein precursor; transforming growth factor-beta receptor type 3-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:100044509)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "25428506;34910520;35957608", "class_list": "", "function": "Expressed in gonadotrope cells, acts as an inhibin B coreceptor and regulates follicle-stimulating hormone (FSH) levels and female fertility., [UniProtKB, PubMed]; Steroidogenic Factor 1 Regulates Transcription of the Inhibin B Coreceptor in Pituitary Gonadotrope Cells., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005024 transforming growth factor beta receptor activity;GO:0005114 type II transforming growth factor beta receptor binding;GO:0005539 glycosaminoglycan binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0017015 regulation of transforming growth factor beta receptor signaling pathway;GO:0016477 cell migration;GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0001837 epithelial to mesenchymal transition", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D3YZZ2-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z6P9-1", "uniprot_id": [ { "id": "D3Z6P9_MOUSE", "url": "https://www.uniprot.org/uniprot/D3Z6P9", "type": "external" } ], "mass": 72271.0, "length": 646, "protein_name": "RNA helicase", "gene_name": "Ddx43", "organism": "Mouse", "refseq_name": "probable ATP-dependent RNA helicase DDX43", "refseq_ac": [ { "id": "NP_001177973", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001177973", "type": "external" } ], "gene_names_uniprotkb": "Ddx43", "gene_names_refseq": "Ddx43", "protein_names_uniprotkb": "RNA helicase; 3.6.4.13", "protein_names_refseq": "DEAD (Asp-Glu-Ala-Asp) box polypeptide 43; probable ATP-dependent RNA helicase DDX43", "tax_id": 10090, "disease": "", "pathway": " (mmu:100048658)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;22393060", "class_list": "", "function": "The helicase HAGE is required for ABCB5+ MMIC-dependent tumor growth through promoting RAS protein expression, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0003724 RNA helicase activity", "go_cellular_component": "", "go_biological_process": "GO:0045445 myoblast differentiation;GO:0061614 miRNA transcription;GO:0000380 alternative mRNA splicing, via spliceosome;GO:0000381 regulation of alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3Z6P9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PXF0-1", "uniprot_id": [ { "id": "E9PXF0_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PXF0", "type": "external" } ], "mass": 126147.0, "length": 1157, "protein_name": "Protocadherin 17", "gene_name": "Pcdh17", "organism": "Mouse", "refseq_name": "protocadherin-17 precursor", "refseq_ac": [ { "id": "NP_001013775", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013775", "type": "external" } ], "gene_names_uniprotkb": "Pcdh17", "gene_names_refseq": "C030033F14Rik; Gm78; Pcdh17", "protein_names_uniprotkb": "Protocadherin 17", "protein_names_refseq": "protocadherin 68; protocadherin-17 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:219228)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;30899004;38747058", "class_list": "", "function": "PCDH17 restricts dendritic spine morphogenesis by regulating ROCK2-dependent control of the actin cytoskeleton, modulating emotional behavior., [RefSeq, PubMed]; This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein contains six extracellular cadherin domains, a transmembrane domain, and a cytoplasmic tail differing from those of the classical cadherins. The encoded protein may play a role in the establishment and function of specific cell-cell connections in the brain. [provided by RefSeq, Sep 2009]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 9, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0045211 postsynaptic membrane;GO:0042734 presynaptic membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0030534 adult behavior;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0050805 negative regulation of synaptic transmission;GO:0099560 synaptic membrane adhesion", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "E9PXF0-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6U238-1", "uniprot_id": [ { "id": "F6U238_MOUSE", "url": "https://www.uniprot.org/uniprot/F6U238", "type": "external" } ], "mass": 126946.0, "length": 1170, "protein_name": "Mastermind like transcriptional coactivator 2", "gene_name": "Maml2", "organism": "Mouse", "refseq_name": "mastermind-like protein 2 isoform 1", "refseq_ac": [ { "id": "NP_001013835", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013835", "type": "external" } ], "gene_names_uniprotkb": "Maml2", "gene_names_refseq": "5930431H10; Maml2", "protein_names_uniprotkb": "Mastermind like transcriptional coactivator 2", "protein_names_refseq": "mastermind like 2; mastermind-like protein 2 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:270118); (R-MMU-2122947); (R-MMU-350054); (R-MMU-8941856)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;21750661", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 9737, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0016604 nuclear body", "go_biological_process": "GO:0007221 positive regulation of transcription of Notch receptor target;GO:0006351 DNA-templated transcription;GO:0007219 Notch signaling pathway;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "F6U238-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F7AIG4-1", "uniprot_id": [ { "id": "F7AIG4_MOUSE", "url": "https://www.uniprot.org/uniprot/F7AIG4", "type": "external" } ], "mass": 9789.0, "length": 85, "protein_name": "Zinc finger protein 999", "gene_name": "Zfp999", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Zfp999; Gm10772; Gm17353", "gene_names_refseq": "", "protein_names_uniprotkb": "Zinc finger protein 999", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F7AIG4-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "J3QNS5-1", "uniprot_id": [ { "id": "J3QNS5_MOUSE", "url": "https://www.uniprot.org/uniprot/J3QNS5", "type": "external" } ], "mass": 54626.0, "length": 503, "protein_name": "Major facilitator superfamily domain containing 4B4", "gene_name": "Mfsd4b4", "organism": "Mouse", "refseq_name": "major facilitator superfamily domain containing 4B4 isoform 1", "refseq_ac": [ { "id": "NP_001371154", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001371154", "type": "external" } ], "gene_names_uniprotkb": "Mfsd4b4; AA474331", "gene_names_refseq": "213332; Mfsd4b4", "protein_names_uniprotkb": "Major facilitator superfamily domain containing 4B4", "protein_names_refseq": "major facilitator superfamily domain containing 4B4 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:213332); (R-MMU-189200)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "J3QNS5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "K7N6W5-1", "uniprot_id": [ { "id": "K7N6W5_MOUSE", "url": "https://www.uniprot.org/uniprot/K7N6W5", "type": "external" } ], "mass": 30170.0, "length": 255, "protein_name": "Predicted gene 17019", "gene_name": "Gm17019", "organism": "Mouse", "refseq_name": "spermatogenesis associated glutamate (E)-rich protein 4-like", "refseq_ac": [ { "id": "NP_892002", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_892002", "type": "external" } ], "gene_names_uniprotkb": "Gm17019", "gene_names_refseq": "Gm17019", "protein_names_uniprotkb": "Predicted gene 17019", "protein_names_refseq": "spermatogenesis associated glutamate (E)-rich protein 4-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:66773)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "K7N6W5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "L7MTU6-1", "uniprot_id": [ { "id": "L7MTU6_MOUSE", "url": "https://www.uniprot.org/uniprot/L7MTU6", "type": "external" } ], "mass": 21589.0, "length": 190, "protein_name": "Interferon alpha B", "gene_name": "Ifnab", "organism": "Mouse", "refseq_name": "interferon alpha family, gene B precursor", "refseq_ac": [ { "id": "NP_032362", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032362", "type": "external" } ], "gene_names_uniprotkb": "Ifnab", "gene_names_refseq": "If1ai8; Ifnab", "protein_names_uniprotkb": "Interferon alpha B", "protein_names_refseq": "interferon 1ai8; interferon alpha family, gene B precursor; interferon alpha family, gene B", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); common cold (Disease Ontology:DOID:10459); anogenital venereal wart (Disease Ontology:DOID:11168); sarcoidosis (Disease Ontology:DOID:11335); Crimean-Congo hemorrhagic fever (Disease Ontology:DOID:12287); hepatitis C (Disease Ontology:DOID:1883); hepatitis B (Disease Ontology:DOID:2043); melioidosis (Disease Ontology:DOID:5052); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:15974); (R-MMU-909733); (R-MMU-912694)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005132 type I interferon receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0002312 B cell activation involved in immune response;GO:0051607 defense response to virus;GO:0060337 type I interferon-mediated signaling pathway;GO:0002250 adaptive immune response;GO:0043330 response to exogenous dsRNA", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "L7MTU6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "L7N463-1", "uniprot_id": [ { "id": "L7N463_MOUSE", "url": "https://www.uniprot.org/uniprot/L7N463", "type": "external" } ], "mass": 57214.0, "length": 504, "protein_name": "Cytochrome P450", "gene_name": "Cyp2d34", "organism": "Mouse", "refseq_name": "cytochrome P450, family 2, subfamily d, polypeptide 34", "refseq_ac": [ { "id": "NP_663449", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663449", "type": "external" } ], "gene_names_uniprotkb": "Cyp2d34", "gene_names_refseq": "Cyp2d34", "protein_names_uniprotkb": "Cytochrome P450; 1.14.14.-", "protein_names_refseq": "cytochrome P450, family 2, subfamily d, polypeptide 34", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); extrapyramidal and movement disease (Disease Ontology:DOID:13839); major depressive disorder (Disease Ontology:DOID:1470); depressive disorder (Disease Ontology:DOID:1596); autoimmune hepatitis (Disease Ontology:DOID:2048); opiate dependence (Disease Ontology:DOID:2559); asthma (Disease Ontology:DOID:2841); rhinitis (Disease Ontology:DOID:4483); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); acute myeloid leukemia (Disease Ontology:DOID:9119); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:223706)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" }, { "id": "1.14.14.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.-", "type": "external" }, { "id": "4.2.1.152", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.152", "type": "external" }, { "id": "1.14.13.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.n7", "type": "external" }, { "id": "5.3.99.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.5", "type": "external" } ], "go_molecular_function": "GO:0070330 aromatase activity;GO:0005506 iron ion binding;GO:0016491 oxidoreductase activity;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0019369 arachidonate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "L7N463-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0QWB7-1", "uniprot_id": [ { "id": "ASCL5_MOUSE", "url": "https://www.uniprot.org/uniprot/M0QWB7", "type": "external" } ], "mass": 20371.0, "length": 188, "protein_name": "Achaete-scute homolog 5", "gene_name": "Ascl5", "organism": "Mouse", "refseq_name": "achaete-scute homolog 5", "refseq_ac": [ { "id": "NP_001257538", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257538", "type": "external" } ], "gene_names_uniprotkb": "Ascl5; AmeloD; bHLHa47", "gene_names_refseq": "AmeloD; Ascl5-ps; Ascl5; Gm197; bHLHa47", "protein_names_uniprotkb": "Achaete-scute homolog 5; Achaete-scute family bHLH transcription factor 5", "protein_names_refseq": "achaete-scute complex homolog 5, pseudogene; achaete-scute homolog 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:226439)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "30426815;30504223;33844290;34812512", "class_list": "", "function": "AmeloD stimulates epithelial cell motility essential for tooth morphology, [RefSeq, PubMed]; The tooth-specific basic helix-loop-helix factor AmeloD promotes differentiation of ameloblasts., [RefSeq, PubMed]; Transcription factor (PubMed:30426815). Probably binds E-box motifs 5'-CANNTG-3' in complex with transcription factor TCF3/E12 (PubMed:30426815). Negatively modulates transcription of target genes such as CDH1/E-cadherin, perhaps by recruiting the PRC2 repressive complex to regulatory elements (PubMed:30426815, PubMed:30504223). Regulates ameloblast development and tooth germ growth, perhaps acting by positively modulating migration of inner enamel epithelium (IEE) cells (PubMed:30426815, PubMed:30504223, PubMed:34812512). Plays a role in enamel formation (PubMed:34812512)., [UniProtKB, PubMed, PubMed, PubMed]; Transcriptional regulation of the basic helix-loop-helix factor AmeloD during tooth development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0000785 chromatin;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0097186 amelogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "M0QWB7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "S4R181-1", "uniprot_id": [ { "id": "S4R181_MOUSE", "url": "https://www.uniprot.org/uniprot/S4R181", "type": "external" } ], "mass": 51140.0, "length": 449, "protein_name": "Coiled-coil domain containing 166", "gene_name": "Ccdc166", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 166 isoform 1", "refseq_ac": [ { "id": "NP_666171", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666171", "type": "external" } ], "gene_names_uniprotkb": "Ccdc166", "gene_names_refseq": "2410075B13Rik; 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May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. Inhibits MAPK8 independently of CDC42 binding. Controls septin organization and this effect is negatively regulated by CDC42., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3SYK1;Q9QZT9", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0007254 JNK cascade;GO:0007266 Rho protein signal transduction;GO:0008360 regulation of cell shape;GO:0031274 positive regulation of pseudopodium assembly;GO:0030838 positive regulation of actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9Z0X0-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35490-1", "uniprot_id": [ { "id": "BHMT1_MOUSE", "url": "https://www.uniprot.org/uniprot/O35490", "type": "external" } ], "mass": 45021.0, "length": 407, "protein_name": "Betaine--homocysteine S-methyltransferase 1", "gene_name": "Bhmt", "organism": "Mouse", "refseq_name": "betaine--homocysteine S-methyltransferase 1", "refseq_ac": [ { "id": "NP_057877", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_057877", "type": "external" } ], "gene_names_uniprotkb": "Bhmt", "gene_names_refseq": "Bhmt", "protein_names_uniprotkb": "Betaine--homocysteine S-methyltransferase 1; 2.1.1.5", "protein_names_refseq": "betaine--homocysteine S-methyltransferase 1", "tax_id": 10090, "disease": "metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); alcohol-associated liver disease (Disease Ontology:DOID:0070658); cerebral infarction (Disease Ontology:DOID:3526); hepatocellular carcinoma (Disease Ontology:DOID:684); pulmonary embolism (Disease Ontology:DOID:9477)", "pathway": " (mmu:12116); (R-MMU-1614635); (R-MMU-6798163)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10854776;23806337;30084848;34428180;36064721;37453647;38804232", "class_list": "", "function": "Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline., [UniProtKB, UniProtKB]; Regulation of Betaine Homocysteine Methyltransferase by Liver Receptor Homolog-1 in the Methionine Cycle., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UEM1;Q3UL72;Q561N0", "ec_number_list": [ { "id": "2.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.5", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0008168 methyltransferase activity;GO:0047150 betaine-homocysteine S-methyltransferase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005829 cytosol;GO:0070062 extracellular exosome;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006479 protein methylation;GO:0009086 methionine biosynthetic process;GO:0006577 amino-acid betaine metabolic process;GO:0006579 amino-acid betaine catabolic process;GO:0071267 L-methionine salvage", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O35490-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35607-1", "uniprot_id": [ { "id": "BMPR2_MOUSE", "url": "https://www.uniprot.org/uniprot/O35607", "type": "external" } ], "mass": 115020.0, "length": 1038, "protein_name": "Bone morphogenetic protein receptor type-2", "gene_name": "Bmpr2", "organism": "Mouse", "refseq_name": "bone morphogenetic protein receptor type-2 precursor", "refseq_ac": [ { "id": "NP_031587", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031587", "type": "external" } ], "gene_names_uniprotkb": "Bmpr2", "gene_names_refseq": "2610024H22Rik; BMP-2; BMPR-2; BMPR-II; BMPRII; BRK-3; Bmpr2; Gm20272", "protein_names_uniprotkb": "Bone morphogenetic protein receptor type-2; 2.7.11.30; BMP type II receptor; BMP type-2 receptor; BMPR-2; BMPR-II; BRK-3; Bone morphogenetic protein receptor type II", "protein_names_refseq": "BMP type II receptor; BMP type-2 receptor; bone morphogenetic protein receptor type-2 precursor; bone morphogenetic protein receptor, type II (serine/threonine kinase); bone morphogenic protein receptor, type II (serine/threonine kinase)", "tax_id": 10090, "disease": "pulmonary venoocclusive disease 1 (Disease Ontology:DOID:0081268); primary pulmonary hypertension (Disease Ontology:DOID:14557); heart septal defect (Disease Ontology:DOID:1681); asthma (Disease Ontology:DOID:2841); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (mmu:12168); (R-MMU-201451)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;16155937;21183079;22645316;23527555;25428506;26495903;30899004;34428180;34678516;35820727;37828378;37908354;9207184", "class_list": "", "function": "On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Can also mediate signaling through the activation of the p38MAPK cascade (By similarity). Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6 (PubMed:23527555). Promotes signaling also by binding to activin A/INHBA (By similarity)., [UniProtKB, UniProtKB, PubMed]; Schistosomiasis-associated pulmonary hypertension unveils disrupted murine gut-lung microbiome and reduced endoprotective Caveolin-1/BMPR2 expression. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a serine/threonine kinase that functions as a receptor for bone morphogenetic proteins (BMPs). The encoded protein is a type II receptor that binds extracellular BMPs and forms a complex of two type II and two type I receptors at the cell membrane. This complex signals downstream to activate SMAD transcriptional regulators. This signaling is important during embryonic development. Mutations in this gene can cause pulmonary hypertension. [provided by RefSeq, Mar 2013]., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 5, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.11.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.30", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019838 growth factor binding;GO:0046872 metal ion binding;GO:0045296 cadherin binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0005912 adherens junction;GO:0009986 cell surface", "go_biological_process": "GO:0001708 cell fate specification;GO:0001525 angiogenesis;GO:0010628 positive regulation of gene expression;GO:0030154 cell differentiation;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "O35607-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56818-1", "uniprot_id": [ { "id": "BACE1_MOUSE", "url": "https://www.uniprot.org/uniprot/P56818", "type": "external" } ], "mass": 55748.0, "length": 501, "protein_name": "Beta-secretase 1", "gene_name": "Bace1", "organism": "Mouse", "refseq_name": "beta-secretase 1 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001139419", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139419", "type": "external" } ], "gene_names_uniprotkb": "Bace1; Bace", "gene_names_refseq": "ASP2; Bace1; Bace", "protein_names_uniprotkb": "Beta-secretase 1; 3.4.23.46; ASP2; Asp 2; Aspartyl protease 2; Beta-site APP cleaving enzyme 1; Beta-site amyloid precursor protein cleaving enzyme 1; Memapsin-2; Membrane-associated aspartic protease 2", "protein_names_refseq": "APP beta-secretase; asp 2; aspartyl protease 2; beta-secretase 1 isoform 2 precursor; beta-secretase 1; beta-site amyloid precursor protein cleaving enzyme 1; memapsin-2; membrane-associated aspartic protease 2", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); dementia (Disease Ontology:DOID:1307); alcohol use disorder (Disease Ontology:DOID:1574); transient cerebral ischemia (Disease Ontology:DOID:224); sensory peripheral neuropathy (Disease Ontology:DOID:2491); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:23821)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;10531052;10591213;15987683;16407538;19074428;19935654;20826464;21183079;21750661;23931995;25592972;26317805;26467158;29325091", "class_list": "", "function": "Responsible for the proteolytic processing of the amyloid precursor protein (APP) (PubMed:29325091). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase (PubMed:29325091). Cleaves CHL1 (PubMed:29325091)., [UniProtKB, PubMed]; Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. Cleaves CHL1., [UniProtKB, UniProtKB]; This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients. Homozygous knockout mice for this gene exhibit a wide range of nervous system defects, growth retardation, metabolic abnormalities, and increased neonatal lethality. [provided by RefSeq, Nov 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 2, "mined_n_glycosites": 2, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9737, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q544D0", "ec_number_list": [], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0019899 enzyme binding;GO:0001540 amyloid-beta binding;GO:0008233 peptidase activity;GO:0004190 aspartic-type endopeptidase activity", "go_cellular_component": "GO:0005768 endosome;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0006509 membrane protein ectodomain proteolysis;GO:0007613 memory;GO:0010288 response to lead ion;GO:0016485 protein processing", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P56818-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1000100000001.110.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VBW5-1", "uniprot_id": [ { "id": "BBX_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VBW5", "type": "external" } ], "mass": 100783.0, "length": 907, "protein_name": "HMG box transcription factor BBX", "gene_name": "Bbx", "organism": "Mouse", "refseq_name": "HMG box transcription factor BBX isoform 2", "refseq_ac": [ { "id": "NP_001334169", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334169", "type": "external" } ], "gene_names_uniprotkb": "Bbx; Hbp2", "gene_names_refseq": "5530401J07Rik; 5730403O13Rik; Bbx", "protein_names_uniprotkb": "HMG box transcription factor BBX; Bobby sox homolog; HMG box-containing protein 2", "protein_names_refseq": "HMG box transcription factor BBX isoform 2; HMG box transcription factor BBX; HMG box-containing protein 2; bobby sox homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:70508)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11680820;19144319;21183079;27802388", "class_list": "", "function": "Transcription factor that is necessary for cell cycle progression from G1 to S phase., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B8JK46;B8JK47;B8JK48;B8JK49;Q3TZK1;Q6NXY8;Q6PEU3;Q8BQJ7;Q8C7E0;Q8CDQ0;Q8CDV1;Q8VI48;Q8VI49;Q8VI50;Q9CS94", "ec_number_list": [], "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0060348 bone development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8VBW5-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VIM4-1", "uniprot_id": [ { "id": "BSND_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VIM4", "type": "external" } ], "mass": 33813.0, "length": 307, "protein_name": "Barttin", "gene_name": "Bsnd", "organism": "Mouse", "refseq_name": "barttin", "refseq_ac": [ { "id": "NP_536706", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_536706", "type": "external" } ], "gene_names_uniprotkb": "Bsnd", "gene_names_refseq": "Bsnd", "protein_names_uniprotkb": "Barttin", "protein_names_refseq": "Bartter syndrome, infantile, with sensorineural deafness (Barttin); barttin", "tax_id": 10090, "disease": "Bartter disease type 4a (Disease Ontology:DOID:0110145); sensorineural hearing loss (Disease Ontology:DOID:10003); Bartter disease (Disease Ontology:DOID:445)", "pathway": " (mmu:140475); (R-MMU-2672351)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "11687798;11734858;18614997;18833191;21183079;21593186;23791703;29326302;31879347", "class_list": "", "function": "Induction of SGK1, CLC-K1 and barttin by high osmolarity and change in intracellular volume in distal renal tubular cells in vivo and in vitro, [RefSeq, PubMed]; Mouse genetics reveals Barttin as a genetic modifier of Joubert syndrome., [RefSeq, PubMed]; Our study provides in vivo evidence that, in response to a low-potassium diet, ClC-K and barttin play important roles in the activation of the WNK4-SPAK-NCC cascade and blood pressure regulation. Publication Status: Online-Only, [RefSeq, PubMed]; Regulatory subunit of anion-selective CLCNKA:BSND and CLCNKB:BSND heteromeric channels involved in basolateral chloride conductance along the nephron to achieve urine concentration and maintain systemic acid-base homeostasis, and in the stria vascularis of the inner ear to establish the endocochlear potential necessary for normal hearing (PubMed:11734858, PubMed:18833191, PubMed:21593186, PubMed:23791703). Most likely acts as a chaperone that allosterically regulates proper sorting of CLCNKA:BSND and CLCNKB:BSND channels at the basolateral plasma membrane domain and functional switch to ion conducting state. Mediates constitutive opening of channel common gates (PubMed:11734858, PubMed:18833191, PubMed:21593186, PubMed:23791703)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AZI5;Q8C740;Q8CHY0", "ec_number_list": [], "go_molecular_function": "GO:0017081 chloride channel regulator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0030644 intracellular chloride ion homeostasis;GO:0007605 sensory perception of sound;GO:0006821 chloride transport;GO:1902476 chloride transmembrane transport;GO:0006873 intracellular monoatomic ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8VIM4-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYE3-1", "uniprot_id": [ { "id": "BC11A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QYE3", "type": "external" } ], "mass": 91197.0, "length": 835, "protein_name": "BCL11 transcription factor A", "gene_name": "Bcl11a", "organism": "Mouse", "refseq_name": "BCL11 transcription factor A isoform 2", "refseq_ac": [ { "id": "NP_001152761", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152761", "type": "external" } ], "gene_names_uniprotkb": "Bcl11a; Ctip1; Evi9; Kiaa1809", "gene_names_refseq": "2810047E18Rik; BCL-11A; Bcl11a; Ctip1; D930021L15Rik; Evi9a; Evi9b; Evi9c; Evi9; mKIAA1809", "protein_names_uniprotkb": "BCL11 transcription factor A; B-cell CLL/lymphoma 11A; B-cell lymphoma/leukemia 11A; BCL-11A; COUP-TF-interacting protein 1; EVI-9; Ecotropic viral integration site 9 protein", "protein_names_refseq": "B cell CLL/lymphoma 11A (zinc finger protein); B-cell CLL/lymphoma 11A; B-cell lymphoma/leukemia 11A; BCL11 transcription factor A isoform 2; COUP-TF interacting protein 1; EVI-9; ecotropic viral integration site 9 protein; myeloid leukemia", "tax_id": 10090, "disease": "specific developmental disorder (Disease Ontology:DOID:0060038); autism spectrum disorder (Disease Ontology:DOID:0060041); sickle cell anemia (Disease Ontology:DOID:10923); beta thalassemia (Disease Ontology:DOID:12241); neurodegenerative disease (Disease Ontology:DOID:1289); lung non-small cell carcinoma (Disease Ontology:DOID:3908); schizophrenia (Disease Ontology:DOID:5419); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:14025); (R-MMU-9933946); (R-MMU-9934037)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;10744719;10757802;12717432;18681895;21183079;21750661;23644491;24129315;25605945;27453576;30084848;30779550", "class_list": "", "function": "Transcription factor (By similarity). Associated with the BAF SWI/SNF chromatin remodeling complex (PubMed:23644491). Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes (By similarity). Involved in brain development (By similarity). May play a role in hematopoiesis (PubMed:10757802). Essential factor in lymphopoiesis, required for B-cell formation in fetal liver (PubMed:12717432). May function as a modulator of the transcriptional repression activity of NR2F2 (PubMed:10744719)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q5STS9;Q80T89;Q8BLC7;Q8BLR4;Q8BWX3;Q921V4;Q9D0V2;Q9JIT4;Q9JLK8;Q9JLK9", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0019901 protein kinase binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016514 SWI/SNF complex;GO:0098794 postsynapse", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9QYE3-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C9S4-1", "uniprot_id": [ { "id": "CC186_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C9S4", "type": "external" } ], "mass": 104901.0, "length": 917, "protein_name": "Coiled-coil domain-containing protein 186", "gene_name": "Ccdc186", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 186", "refseq_ac": [ { "id": "NP_739563", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_739563", "type": "external" } ], "gene_names_uniprotkb": "Ccdc186; A630007B06Rik; Otg1", "gene_names_refseq": "1810028B20Rik; A630007B06Rik; Ccdc186; Otg1", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 186; Oocyte-testis gene 1 protein", "protein_names_refseq": "coiled-coil domain-containing protein 186; oocyte-testis gene 1 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:213993)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21183079;21750661;30059200", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6P3D6;Q8CJC0", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0009617 response to bacterium;GO:0042593 glucose homeostasis;GO:0035773 insulin secretion involved in cellular response to glucose stimulus;GO:0099518 vesicle cytoskeletal trafficking", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8C9S4-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48758-1", "uniprot_id": [ { "id": "CBR1_MOUSE", "url": "https://www.uniprot.org/uniprot/P48758", "type": "external" } ], "mass": 30641.0, "length": 277, "protein_name": "Carbonyl reductase [NADPH] 1", "gene_name": "Cbr1", "organism": "Mouse", "refseq_name": "carbonyl reductase [NADPH] 1", "refseq_ac": [ { "id": "NP_031646", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031646", "type": "external" } ], "gene_names_uniprotkb": "Cbr1; Cbr", "gene_names_refseq": "CR; Cbr1; Cbr; PG-9-KR", "protein_names_uniprotkb": "Carbonyl reductase [NADPH] 1; 1.1.1.184; 1.1.1.189; 1.1.1.196; 1.1.1.197; 1.1.1.71; 15-hydroxyprostaglandin dehydrogenase [NADP(+)]; 20-beta-hydroxysteroid dehydrogenase; Alcohol dehydrogenase [NAD(P)+] CBR1; NADPH-dependent carbonyl reductase 1; PG-9-KR; Prostaglandin 9-ketoreductase; Prostaglandin-E(2) 9-reductase", "protein_names_refseq": "15-hydroxyprostaglandin dehydrogenase; 20-beta-hydroxysteroid dehydrogenase; Carbonyl reductase [NADPH] 1 (NADPH-dependent carbonyl reductase 1); NADPH-dependent carbonyl reductase 1; alcohol dehydrogenase [NAD(P)+] CBR1; carbonyl reductase [NADPH] 1; prostaglandin 9-ketoreductase; prostaglandin-E(2) 9-reductase", "tax_id": 10090, "disease": "chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (mmu:12408); (R-MMU-2162123)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "21183079;21750661;23732109;26495903;28011936;28878267;30084848;31955137;32843708;33300544;33785425;34428180;37453647;37507081;39927985;8661038", "class_list": "", "function": "CBR1 plays a critical role in controlling redox balance and detoxifying lipid peroxidation during muscle differentiation and regeneration., [RefSeq, PubMed]; Carbonyl Reductase 1 Plays a Significant Role in Converting Doxorubicin to Cardiotoxic Doxorubicinol in Mouse Liver, but the Majority of the Doxorubicinol-Forming Activity Remains Unidentified., [RefSeq, PubMed]; Carbonyl reductase 1 amplifies glucocorticoid action in adipose tissue and impairs glucose tolerance in lean mice., [RefSeq, PubMed]; Impairment of spatial memory accuracy improved by Cbr1 copy number resumption and GABAB receptor-dependent enhancement of synaptic inhibition in Down syndrome model mice. Publication Status: Online-Only, [RefSeq, PubMed]; NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol (By similarity). Can convert prostaglandin E to prostaglandin F2-alpha (By similarity). Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione. In addition, participates in the glucocorticoid metabolism by catalyzing the NADPH-dependent cortisol/corticosterone into 20beta-dihydrocortisol (20b-DHF) or 20beta-corticosterone (20b-DHB), which are weak agonists of NR3C1 and NR3C2 in adipose tissue (PubMed:28878267, PubMed:33785425)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; These findings suggest that CBR1 generating 20beta-dihydrocortisol is a novel pathway modulating GR activation and providing enzymatic protection against excessive GR activation in obesity. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91X28", "ec_number_list": [ { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "1.1.1.189", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.189", "type": "external" }, { "id": "1.1.1.197", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.197", "type": "external" }, { "id": "1.1.1.196", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.196", "type": "external" }, { "id": "1.1.1.71", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.71", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.6.5.10", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.10", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.2", "type": "external" }, { "id": "1.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.-.-", "type": "external" }, { "id": "1.1.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.19", "type": "external" }, { "id": "1.1.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.20", "type": "external" }, { "id": "1.1.1.372", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.372", "type": "external" }, { "id": "1.1.1.54", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.54", "type": "external" } ], "go_molecular_function": "GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor;GO:0047020 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity;GO:0004090 carbonyl reductase (NADPH) activity;GO:0047021 15-hydroxyprostaglandin dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005902 microvillus", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0032570 response to progesterone;GO:1905344 prostaglandin catabolic process;GO:0032355 response to estradiol;GO:2000379 positive regulation of reactive oxygen species metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P48758-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R171-1", "uniprot_id": [ { "id": "CBLN1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R171", "type": "external" } ], "mass": 21113.0, "length": 193, "protein_name": "Cerebellin-1", "gene_name": "Cbln1", "organism": "Mouse", "refseq_name": "cerebellin-1 precursor", "refseq_ac": [ { "id": "NP_062600", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062600", "type": "external" } ], "gene_names_uniprotkb": "Cbln1", "gene_names_refseq": "Cbln1", "protein_names_uniprotkb": "Cerebellin-1; Brain protein D3; Precerebellin", "protein_names_refseq": "brain protein D3; cerebellin-1 precursor; precerebellin", "tax_id": 10090, "disease": "", "pathway": " (mmu:12404)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "10.1101/2023.09.13.557529;10964938;12106288;16135095;16234806;16930405;17030622;17331201;19200061;20395510;20856818;21410790;22220752;23141067;24467251;29691328;29782851;3199194;33300544;3420533;36823038;7877445;9838062", "class_list": "", "function": "Cbln1 Directs Axon Targeting by Corticospinal Neurons Specifically toward Thoraco-Lumbar Spinal Cord., [RefSeq, PubMed]; Required for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the matching and maintenance of pre- and post-synaptic elements at parallel fiber-Purkinje cell synapses, the establishment of the proper pattern of climbing fiber-Purkinje cell innervation, and induction of long-term depression at parallel fiber-Purkinje cell synapses (PubMed:16234806). Plays a role as a synaptic organizer that acts bidirectionally on both pre- and post-synaptic components (PubMed:20395510). On the one hand induces accumulation of synaptic vesicles in the pre-synaptic part by binding with NRXN1 and in other hand induces clustering of GRID2 and its associated proteins at the post-synaptic site through association of GRID2 (PubMed:21410790). NRXN1-CBLN1-GRID2 complex directly induces parallel fiber protrusions that encapsulate spines of Purkinje cells leading to accumulation of GRID2 and synaptic vesicles (PubMed:23141067). Required for CBLN3 export from the endoplasmic reticulum and secretion (PubMed:17030622, PubMed:17331201). NRXN1-CBLN1-GRID2 complex mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis (By similarity). Essential for long-term maintenance but not establishment of excitatory synapses (PubMed:29691328). Inhibits the formation and function of inhibitory GABAergic synapses in cerebellar Purkinje cells (PubMed:24467251)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; The cerebellin peptide exerts neuromodulatory functions. Directly stimulates norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "P28655;Q9QVT5", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0030545 signaling receptor regulator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0045202 synapse;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0050808 synapse organization;GO:0051965 positive regulation of synapse assembly;GO:0099558 maintenance of synapse structure;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0009306 protein secretion", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "Q9R171-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTK2-1", "uniprot_id": [ { "id": "CDYL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WTK2", "type": "external" } ], "mass": 65211.0, "length": 593, "protein_name": "Chromodomain Y-like protein", "gene_name": "Cdyl", "organism": "Mouse", "refseq_name": "chromodomain Y-like protein isoform 2", "refseq_ac": [ { "id": "NP_001116858", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116858", "type": "external" } ], "gene_names_uniprotkb": "Cdyl", "gene_names_refseq": "Cdyl", "protein_names_uniprotkb": "Chromodomain Y-like protein; 2.3.1.48; 4.2.1.-; CDY-like; Crotonyl-CoA hydratase; Putative histone acetyltransferase Cdyl", "protein_names_refseq": "CDY-like; chromodomain Y-like protein isoform 2; chromodomain Y-like protein; crotonyl-CoA hydratase; putative histone acetyltransferase Cdyl", "tax_id": 10090, "disease": "epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:12593)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10192397;12072557;12947414;21183079;21540332;21750661;22645316;24144980;27932493;28076783;28803779;28842554;29177481;30665597;36464171;37155872;39378153", "class_list": "", "function": "CDYL reinforces male gonadal sex determination through epigenetically repressing Wnt4 transcription in mice., [RefSeq, PubMed]; Chromatin reader protein that recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively) (PubMed:12947414). Part of multimeric repressive chromatin complexes, where it is required for transmission and restoration of repressive histone marks, thereby preserving the epigenetic landscape (PubMed:12947414). Required for chromatin targeting and maximal enzymatic activity of Polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing histone H3K27me3 and newly recruited PRC2 on neighboring nucleosomes (By similarity). Acts as a corepressor for REST by facilitating histone-lysine N-methyltransferase EHMT2 recruitment and H3K9 dimethylation at REST target genes for repression (By similarity). Involved in X chromosome inactivation in females: recruited to Xist RNA-coated X chromosome and facilitates propagation of H3K9me2 by anchoring EHMT2 (PubMed:24144980). Promotes EZH2 accumulation and H3K27me3 methylation at DNA double strand breaks (DSBs), thereby facilitating transcriptional repression at sites of DNA damage and homology-directed repair of DSBs (By similarity). Required for neuronal migration during brain development by repressing expression of RHOA (PubMed:28076783). By repressing the expression of SCN8A, contributes to the inhibition of intrinsic neuronal excitability and epileptogenesis (PubMed:28842554). In addition to acting as a chromatin reader, acts as a hydro-lyase (By similarity). Shows crotonyl-coA hydratase activity by mediating the conversion of crotonyl-CoA ((2E)-butenoyl-CoA) to beta-hydroxybutyryl-CoA (3-hydroxybutanoyl-CoA), thereby acting as a negative regulator of histone crotonylation (By similarity). Histone crotonylation is required during spermatogenesis; down-regulation of histone crotonylation by CDYL regulates the reactivation of sex chromosome-linked genes in round spermatids and histone replacement in elongating spermatids (PubMed:28803779). By regulating histone crotonylation and trimethylation of H3K27, may be involved in stress-induced depression-like behaviors, possibly by regulating VGF expression (PubMed:30665597). May have histone acetyltransferase activity; such activity is however unsure in vivo (PubMed:12072557)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Disruption of Cdyl gene impairs mouse lung epithelium differentiation and maturation., [RefSeq, PubMed]; Not able to recognize and bind histone H3K9me3, histone H3K27me2 and histone H3K27me3, due to the presence of a N-terminal extension that inactivates the chromo domain., [UniProtKB, UniProtKB]; The chromodomain protein CDYL confers forebrain identity to human cortical organoids by inhibiting neuronatin., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U0W2;Q6P6N3", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "4.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.17", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "2.3.1.259", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.259", "type": "external" }, { "id": "2.3.1.57", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.57", "type": "external" }, { "id": "2.3.1.80", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.80", "type": "external" }, { "id": "4.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0061733 protein-lysine-acetyltransferase activity;GO:0003682 chromatin binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0005694 chromosome", "go_biological_process": "GO:0060816 random inactivation of X chromosome;GO:0006351 DNA-templated transcription;GO:0007286 spermatid development;GO:0120094 negative regulation of peptidyl-lysine crotonylation", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9WTK2-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15530-1", "uniprot_id": [ { "id": "CD79B_MOUSE", "url": "https://www.uniprot.org/uniprot/P15530", "type": "external" } ], "mass": 25726.0, "length": 228, "protein_name": "B-cell antigen receptor complex-associated protein beta chain", "gene_name": "Cd79b", "organism": "Mouse", "refseq_name": "B-cell antigen receptor complex-associated protein beta chain isoform 2 precursor", "refseq_ac": [ { "id": "NP_001300868", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001300868", "type": "external" } ], "gene_names_uniprotkb": "Cd79b; Igb", "gene_names_refseq": "B29; Cd79b; Ig-beta; Igbeta; Igb", "protein_names_uniprotkb": "B-cell antigen receptor complex-associated protein beta chain; B-cell-specific glycoprotein B29; Ig-beta; Immunoglobulin-associated B29 protein", "protein_names_refseq": "B-cell antigen receptor complex-associated protein beta chain isoform 2 precursor; B-cell antigen receptor complex-associated protein beta chain; B-cell-specific glycoprotein B29; immunoglobulin-associated B29 protein; immunoglobulin-associated beta", "tax_id": 10090, "disease": "diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745); mantle cell lymphoma (Disease Ontology:DOID:0050746); splenic marginal zone lymphoma (Disease Ontology:DOID:0050750); follicular lymphoma (Disease Ontology:DOID:0050873); non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); agammaglobulinemia 6 (Disease Ontology:DOID:0081138); chronic lymphocytic leukemia (Disease Ontology:DOID:1040); central nervous system lymphoma (Disease Ontology:DOID:3234); Burkitt lymphoma (Disease Ontology:DOID:8584); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:15985); (R-MMU-5690714); (R-MMU-983695)", "pathway_count": 3, "publication_count": 18, "publication_id_list": "10352267;10587346;11238609;12356683;1506682;15335855;15661879;20696394;21750661;2508087;26495903;26740625;29141870;3137575;34428180;7592958;8175787;8976175", "class_list": "", "function": "Ablation of B cell antigen receptor ubiquitination in vivo uncouples the receptor from CD19 phosphorylation and phosphatidylinositol 3-kinase (PI3K) signals., [RefSeq, PubMed]; Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q4FJP4", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane;GO:0019815 B cell receptor complex;GO:0071755 IgM B cell receptor complex", "go_biological_process": "GO:0009617 response to bacterium;GO:0002250 adaptive immune response;GO:0050853 B cell receptor signaling pathway;GO:0030183 B cell differentiation;GO:0007166 cell surface receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P15530-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11440-1", "uniprot_id": [ { "id": "CDK1_MOUSE", "url": "https://www.uniprot.org/uniprot/P11440", "type": "external" } ], "mass": 34107.0, "length": 297, "protein_name": "Cyclin-dependent kinase 1", "gene_name": "Cdk1", "organism": "Mouse", "refseq_name": "cyclin-dependent kinase 1", "refseq_ac": [ { "id": "NP_031685", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031685", "type": "external" } ], "gene_names_uniprotkb": "Cdk1; Cdc2a; Cdc2; Cdkn1", "gene_names_refseq": "Cdc2a; Cdc2; Cdk1; p34", "protein_names_uniprotkb": "Cyclin-dependent kinase 1; 2.7.11.22; 2.7.11.23; CDK1; Cell division control protein 2 homolog; Cell division protein kinase 1; p34 protein kinase", "protein_names_refseq": "cell cycle p34 CDC2 kinase protein; cell division control protein 2 homolog; cell division cycle 2 homolog A; cell division cycle control protein 2a; cell division protein kinase 1; cyclin-dependent kinase 1; p34 protein kinase", "tax_id": 10090, "disease": "urinary bladder cancer (Disease Ontology:DOID:11054); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); transitional cell carcinoma (Disease Ontology:DOID:2671); gallbladder adenocarcinoma (Disease Ontology:DOID:3500); cervical cancer (Disease Ontology:DOID:4362); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:12534); (R-MMU-110056); (R-MMU-174048); (R-MMU-174184); (R-MMU-176408); (R-MMU-176412); (R-MMU-176417); (R-MMU-2299718); (R-MMU-2500257); (R-MMU-2565942); (R-MMU-2980767); (R-MMU-2995383); (R-MMU-3301854); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-4419969); (R-MMU-5620912); (R-MMU-5687128); (R-MMU-5689896); (R-MMU-6804114); (R-MMU-6804757); (R-MMU-68875); (R-MMU-69273); (R-MMU-69478); (R-MMU-75035); (R-MMU-8852276); (R-MMU-8854518); (R-MMU-8878166); (R-MMU-9833482)", "pathway_count": 31, "publication_count": 51, "publication_id_list": "15459478;15580572;16007079;16169490;16329156;16924665;17242355;17342725;17700700;17942597;18176113;18349838;19131326;19917613;19933706;20428502;21183079;21209834;2132958;21454751;21535921;21750661;2208288;22319576;22331465;22405274;22948297;23616086;23649674;23806337;24340001;24551245;25246615;2662013;27096953;27117522;27196784;29518391;30154440;30616572;30626720;31437213;32850387;33015052;35067737;36210013;36264786;37828378;39409153;9699647;9895127", "class_list": "", "function": "Cdk1 Deficiency Extends the Postnatal Window of Cardiomyocyte Proliferation and Restores Cardiac Function after Myocardial Infarction. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition via association with multiple interphase cyclins (PubMed:16007079, PubMed:17700700, PubMed:17942597, PubMed:22405274). Phosphorylates PARVA/actopaxin, APC, AMPH, APC, ASB7, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, GOLGA2/GM130, GRASP1, UBE2A/hHR6A, HIST1H1 proteins/histone H1, HMGA1, HIVEP3/KRC, UHRF1, KAT5, LMNA, LMNB, LBR, MKI67, LATS1, MAP1B, MAP4, MARCKS, MCM2, MCM4, MKLP1, MLST8, MYB, NEFH, NFIC, NPC/nuclear pore complex, PITPNM1/NIR2, NPM1, NCL, NUCKS1, NPM1/numatrin, ORC1, PRKAR2A, EEF1E1/p18, EIF3F/p47, p53/TP53, NONO/p54NRB, PAPOLA, PLEC/plectin, RB1, TPPP, UL40/R2, RAB4A, RAP1GAP, RBBP8/CtIP, RCC1, RPS6KB1/S6K1, KHDRBS1/SAM68, ESPL1, SKI, BIRC5/survivin, STIP1, TEX14, beta-tubulins, MAPT/TAU, NEDD1, VIM/vimentin, TK1, FOXO1, RUNX1/AML1, SAMHD1, SIRT2, CGAS, GLI2, ZAR1 and RUNX2 (PubMed:17942597, PubMed:22405274, PubMed:36264786). CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized eggs (By similarity). Essential for early stages of embryonic development (By similarity). During G2 and early mitosis, CDC25A/B/C-mediated dephosphorylation activates CDK1/cyclin complexes which phosphorylate several substrates that trigger at least centrosome separation, Golgi dynamics, nuclear envelope breakdown and chromosome condensation (PubMed:16007079, PubMed:17700700). Once chromosomes are condensed and aligned at the metaphase plate, CDK1 activity is switched off by WEE1- and PKMYT1-mediated phosphorylation to allow sister chromatid separation, chromosome decondensation, reformation of the nuclear envelope and cytokinesis (By similarity). Phosphorylates KRT5 during prometaphase and metaphase (PubMed:29518391). Activated by the CDK-activating kinase (CAK) complex consisting of CDK7, cyclin-H/CCNH and MAT1, which is a master regulator of CDK activity (By similarity). Inactivated by PKR/EIF2AK2- and WEE1-mediated phosphorylation upon DNA damage to stop cell cycle and genome replication at the G2 checkpoint thus facilitating DNA repair (By similarity). Reactivated after successful DNA repair through WIP1-dependent signaling leading to CDC25A/B/C-mediated dephosphorylation and restoring cell cycle progression (By similarity). Catalyzes lamin (LMNA, LMNB1 and LMNB2) phosphorylation at the onset of mitosis, promoting nuclear envelope breakdown (By similarity). In proliferating cells, CDK1-mediated FOXO1 phosphorylation at the G2-M phase represses FOXO1 interaction with 14-3-3 proteins and thereby promotes FOXO1 nuclear accumulation and transcription factor activity, leading to cell death of postmitotic neurons (By similarity). The phosphorylation of beta-tubulins regulates microtubule dynamics during mitosis (By similarity). NEDD1 phosphorylation promotes PLK1-mediated NEDD1 phosphorylation and subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation (By similarity). In addition, CC2D1A phosphorylation regulates CC2D1A spindle pole localization and association with SCC1/RAD21 and centriole cohesion during mitosis (By similarity). The phosphorylation of Bcl-xL/BCL2L1 after prolongated G2 arrest upon DNA damage triggers apoptosis (By similarity). In contrast, CASP8 phosphorylation during mitosis prevents its activation by proteolysis and subsequent apoptosis (By similarity). This phosphorylation occurs in cancer cell lines, as well as in primary breast tissues and lymphocytes (By similarity). EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing (By similarity). CALD1 phosphorylation promotes Schwann cell migration during peripheral nerve regeneration (By similarity). CDK1-cyclin-B complex phosphorylates NCKAP5L and mediates its dissociation from centrosomes during mitosis (By similarity). Regulates the amplitude of the cyclic expression of the core clock gene BMAL1 by phosphorylating its transcriptional repressor NR1D1, and this phosphorylation is necessary for SCF(FBXW7)-mediated ubiquitination and proteasomal degradation of NR1D1 (By similarity). Phosphorylates EML3 at 'Thr-881' which is essential for its interaction with HAUS augmin-like complex and TUBG1 (By similarity). Phosphorylates CGAS during mitosis, leading to its inhibition, thereby preventing CGAS activation by self DNA during mitosis (By similarity). Phosphorylates SKA3 during mitosis which promotes SKA3 binding to the NDC80 complex and anchoring of the SKA complex to kinetochores, to enable stable attachment of mitotic spindle microtubules to kinetochores (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P70337;Q3TI12", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "1.3.1.70", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.70", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.4", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005759 mitochondrial matrix;GO:0005813 centrosome", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:1990166 protein localization to site of double-strand break;GO:0046785 microtubule polymerization;GO:0044772 mitotic cell cycle phase transition;GO:0046105 thymidine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 5.2, "record_id": "P11440-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35207-1", "uniprot_id": [ { "id": "CDKA1_MOUSE", "url": "https://www.uniprot.org/uniprot/O35207", "type": "external" } ], "mass": 12354.0, "length": 114, "protein_name": "Cyclin-dependent kinase 2-associated protein 1", "gene_name": "Cdk2ap1", "organism": "Mouse", "refseq_name": "cyclin-dependent kinase 2-associated protein 1", "refseq_ac": [ { "id": "NP_038840", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038840", "type": "external" } ], "gene_names_uniprotkb": "Cdk2ap1; Cdkap1; Doc1", "gene_names_refseq": "Apc10; Cdk2ap1; Cdkap1; DORC1; Doc1; ST19; doc-1; p12", "protein_names_uniprotkb": "Cyclin-dependent kinase 2-associated protein 1; CDK2-associated protein 1; DOC-1; Deleted in oral cancer 1; Putative oral cancer suppressor", "protein_names_refseq": "CDK2 (cyclin-dependent kinase 2)-associated protein 1; CDK2-associated protein 1; cyclin-dependent kinase 2-associated protein 1; deleted in oral cancer 1; putative oral cancer suppressor", "tax_id": 10090, "disease": "", "pathway": " (mmu:13445); (R-MMU-9937850); (R-MMU-9940951)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10938106;15543230;20523938;21750661;25428506;31219806;34428180;34644528", "class_list": "", "function": "(CDK2-AP1) is a potential gene therapeutic agent for oral/head and neck cancer in conjunction with DNA-damaging agents such as cisplatin., [RefSeq, PubMed]; A mouse-specific retrotransposon drives a conserved Cdk2ap1 isoform essential for development., [RefSeq, PubMed]; Inhibitor of cyclin-dependent kinase CDK2 (PubMed:10938106). Also acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (By similarity)., [UniProtKB, UniProtKB, PubMed]; Results indicate that DOC-1 is a bona fide subunit of the Mi-2/NuRD chromatin remodeling complex., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RV53;Q3SYK3;Q6ZWZ1", "ec_number_list": [], "go_molecular_function": "GO:0070182 DNA polymerase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0001934 positive regulation of protein phosphorylation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0060325 face morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O35207-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11911-1", "uniprot_id": [ { "id": "CD79A_MOUSE", "url": "https://www.uniprot.org/uniprot/P11911", "type": "external" } ], "mass": 24583.0, "length": 220, "protein_name": "B-cell antigen receptor complex-associated protein alpha chain", "gene_name": "Cd79a", "organism": "Mouse", "refseq_name": "B-cell antigen receptor complex-associated protein alpha chain precursor", "refseq_ac": [ { "id": "NP_031681", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031681", "type": "external" } ], "gene_names_uniprotkb": "Cd79a; Iga; Mb-1", "gene_names_refseq": "Cd79a; Ig-alpha; Igalpha; Iga; Ly-54; Ly54; mb-1", "protein_names_uniprotkb": "B-cell antigen receptor complex-associated protein alpha chain; Ig-alpha; MB-1 membrane glycoprotein; Membrane-bound immunoglobulin-associated protein; Surface IgM-associated protein", "protein_names_refseq": "B-cell antigen receptor complex-associated protein alpha chain precursor; B-cell antigen receptor complex-associated protein alpha chain; MB-1 membrane glycoprotein; membrane-bound immunoglobulin-associated protein; surface IgM-associated protein", "tax_id": 10090, "disease": "agammaglobulinemia 3 (Disease Ontology:DOID:0081137)", "pathway": " (mmu:12518); (R-MMU-5690714); (R-MMU-983695)", "pathway_count": 3, "publication_count": 36, "publication_id_list": "10352267;10587346;10591178;11238609;11449366;11465105;11514602;11859098;11909947;12097390;12356683;1506682;15335855;15661879;16075062;1639443;16860757;17163454;1922076;20231378;2023945;2269334;2358676;2463161;26495903;28011936;34428180;35984892;7538118;7592958;8168489;8175787;8245790;8306975;8976175;9469435", "class_list": "", "function": "Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6GTY0", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045121 membrane raft;GO:0009897 external side of plasma membrane;GO:0005771 multivesicular body;GO:0019815 B cell receptor complex", "go_biological_process": "GO:0042113 B cell activation;GO:0002250 adaptive immune response;GO:0050853 B cell receptor signaling pathway;GO:0030183 B cell differentiation;GO:0042100 B cell proliferation", "synthesized_glycan_count": 0, "hit_score": 3.9, "record_id": "P11911-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49919-1", "uniprot_id": [ { "id": "CDN1C_MOUSE", "url": "https://www.uniprot.org/uniprot/P49919", "type": "external" } ], "mass": 37372.0, "length": 348, "protein_name": "Cyclin-dependent kinase inhibitor 1C", "gene_name": "Cdkn1c", "organism": "Mouse", "refseq_name": "cyclin-dependent kinase inhibitor 1C isoform 1", "refseq_ac": [ { "id": "NP_001155096", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155096", "type": "external" } ], "gene_names_uniprotkb": "Cdkn1c; Kip2", "gene_names_refseq": "CDKI; Cdkn1c; Kip2; p57(kip2); p57Kip2", "protein_names_uniprotkb": "Cyclin-dependent kinase inhibitor 1C; Cyclin-dependent kinase inhibitor p57; p57Kip2", "protein_names_refseq": "cyclin dependent kinase inhibitor 1C (P57); cyclin-dependent kinase inhibitor 1C isoform 1; cyclin-dependent kinase inhibitor p57", "tax_id": 10090, "disease": "IMAGe syndrome (Disease Ontology:DOID:0050885); pre-eclampsia (Disease Ontology:DOID:10591); lung cancer (Disease Ontology:DOID:1324); hyperinsulinism (Disease Ontology:DOID:2018); Beckwith-Wiedemann syndrome (Disease Ontology:DOID:5572); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:12577); (R-MMU-69231)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "17517131;21750661;24129315;30084848;34428180;7729683;7729684", "class_list": "", "function": "Cdkn1c, an imprinted gene with expression only from the maternal allele, is the major regulator of embryonic growth in the IC2 imprinted domain on mouse distal chromosome 7. Publication Status: Online-Only, [RefSeq, PubMed]; Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "G3UW61", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0004860 protein kinase inhibitor activity;GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity;GO:0140678 molecular function inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001822 kidney development;GO:0045892 negative regulation of DNA-templated transcription;GO:0050680 negative regulation of epithelial cell proliferation;GO:0035264 multicellular organism growth", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P49919-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97377-1", "uniprot_id": [ { "id": "CDK2_MOUSE", "url": "https://www.uniprot.org/uniprot/P97377", "type": "external" } ], "mass": 38978.0, "length": 346, "protein_name": "Cyclin-dependent kinase 2", "gene_name": "Cdk2", "organism": "Mouse", "refseq_name": "cyclin-dependent kinase 2 isoform 2", "refseq_ac": [ { "id": "NP_058036", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058036", "type": "external" } ], "gene_names_uniprotkb": "Cdk2; Cdkn2", "gene_names_refseq": "A630093N05Rik; Cdk2", "protein_names_uniprotkb": "Cyclin-dependent kinase 2; 2.7.11.22; Cell division protein kinase 2", "protein_names_refseq": "cell division protein kinase 2; cyclin-dependent kinase 2 isoform 2", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); interstitial cystitis (Disease Ontology:DOID:13949); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); membranoproliferative glomerulonephritis (Disease Ontology:DOID:2920); renal cell carcinoma (Disease Ontology:DOID:4450)", "pathway": " (mmu:12566); (R-MMU-1538133); (R-MMU-171319); (R-MMU-176187); (R-MMU-176408); (R-MMU-187577); (R-MMU-2559582); (R-MMU-2559586); (R-MMU-5693607); (R-MMU-6804116); (R-MMU-6804756); (R-MMU-6804757); (R-MMU-68911); (R-MMU-68949); (R-MMU-68962); (R-MMU-69017); (R-MMU-69200); (R-MMU-69202); (R-MMU-69231); (R-MMU-69273); (R-MMU-69563); (R-MMU-69656); (R-MMU-8849470); (R-MMU-9616222)", "pathway_count": 24, "publication_count": 30, "publication_id_list": "10903150;11509654;11585773;11733001;12923533;14561402;15107404;17942597;18382684;20173027;21183079;21372285;22761665;23853094;24670654;24797635;24886500;25428506;25428911;25605945;26148348;27449088;30084848;30152757;31704972;33075054;34428180;38297099;8259216;8475101", "class_list": "glycogene", "function": "Lactylation-driven FTO targets CDK2 to aggravate microvascular anomalies in diabetic retinopathy. Erratum:[EMBO Mol Med. 2025 Jun;17(6):1495-1498. doi: 10.1038/s44321-025-00238-y. PMID: 40281307], [RefSeq, PubMed]; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis (PubMed:11733001, PubMed:12923533, PubMed:14561402, PubMed:17942597, PubMed:23853094). Phosphorylates CABLES1, CTNNB1, CDK2AP2, ERCC6, NBN, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, SUV39H1, EZH2 (PubMed:11733001, PubMed:23853094). Triggers duplication of centrosomes and DNA (By similarity). Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus (By similarity). Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in embryonic stem cells (ESCs) (By similarity). Activated by the CDK-activating kinase (CAK) complex consisting of CDK7, cyclin-H/CCNH and MAT1, which is a master regulator of CDK activity (By similarity). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase (By similarity). EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC (By similarity). Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis (By similarity). In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation (By similarity). Involved in regulation of telomere repair by mediating phosphorylation of NBN (By similarity). Phosphorylation of RB1 disturbs its interaction with E2F1 (By similarity). NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociation from unduplicated centrosomes, thus initiating centrosome duplication (By similarity). Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase (By similarity). Required for vitamin D-mediated growth inhibition by being itself inactivated (By similarity). Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner (By similarity). USP37 is activated by phosphorylation and thus triggers G1-S transition (By similarity). CTNNB1 phosphorylation regulates insulin internalization (By similarity). Phosphorylates FOXP3 and negatively regulates its transcriptional activity and protein stability (PubMed:23853094). Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (By similarity). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of the C-terminus of protein kinase B (PKB/AKT1 and PKB/AKT2), promoting its activation (PubMed:24670654)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 11, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O55105", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "5.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.1", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.7.102", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.102", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "5.4.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.-", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005768 endosome", "go_biological_process": "GO:0043247 telomere maintenance in response to DNA damage;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006281 DNA repair;GO:0006468 protein phosphorylation;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "P97377-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0000000000001.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TCJ8-1", "uniprot_id": [ { "id": "CCD69_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TCJ8", "type": "external" } ], "mass": 23296.0, "length": 202, "protein_name": "Coiled-coil domain-containing protein 69", "gene_name": "Ccdc69", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 69", "refseq_ac": [ { "id": "NP_803422", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803422", "type": "external" } ], "gene_names_uniprotkb": "Ccdc69; D11Ertd461e", "gene_names_refseq": "2210021E03Rik; Ccdc69; D11Ertd461e", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 69", "protein_names_refseq": "coiled-coil domain-containing protein 69", "tax_id": 10090, "disease": "", "pathway": " (mmu:52570)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21183079;26740625;34428180", "class_list": "", "function": "May act as a scaffold to regulate the recruitment and assembly of spindle midzone components. Required for the localization of AURKB and PLK1 to the spindle midzone., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C515", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005634 nucleus;GO:0051233 spindle midzone;GO:0030496 midbody", "go_biological_process": "GO:0051255 spindle midzone assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3TCJ8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61003-1", "uniprot_id": [ { "id": "CD6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61003", "type": "external" } ], "mass": 72255.0, "length": 665, "protein_name": "T-cell differentiation antigen CD6", "gene_name": "Cd6", "organism": "Mouse", "refseq_name": "T-cell differentiation antigen CD6 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001032890", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032890", "type": "external" } ], "gene_names_uniprotkb": "Cd6", "gene_names_refseq": "Cd6", "protein_names_uniprotkb": "T-cell differentiation antigen CD6", "protein_names_refseq": "T-cell differentiation antigen CD6 isoform 1 precursor; T-cell differentiation antigen CD6", "tax_id": 10090, "disease": "", "pathway": " (mmu:12511)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;16914752;21750661;24584089;32307907;34981775;7594475;7870060", "class_list": "", "function": "Attenuation of Murine Collagen-Induced Arthritis by Targeting CD6., [RefSeq, PubMed]; Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166. Contributes to signaling cascades triggered by activation of the TCR/CD3 complex (PubMed:24584089). Functions as a costimulatory molecule; promotes T-cell activation and proliferation. Contributes to the formation and maturation of the immunological synapse. Functions as a calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria. LPS binding leads to the activation of signaling cascades and down-stream MAP kinases. Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS., [UniProtKB, UniProtKB, PubMed]; The CD6/ALCAM pathway promotes lupus nephritis via T cell-mediated responses., [RefSeq, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q60679;Q61004;Q8BGK1", "ec_number_list": [], "go_molecular_function": "GO:0005044 scavenger receptor activity;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0001530 lipopolysaccharide binding;GO:0070891 lipoteichoic acid binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0042101 T cell receptor complex;GO:0001772 immunological synapse;GO:0016020 membrane", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0032496 response to lipopolysaccharide;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0042102 positive regulation of T cell proliferation;GO:0031663 lipopolysaccharide-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q61003-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "J3KMM7-1", "uniprot_id": [ { "id": "J3KMM7_MOUSE", "url": "https://www.uniprot.org/uniprot/J3KMM7", "type": "external" } ], "mass": 12948.0, "length": 116, "protein_name": "RIKEN cDNA A630095N17 gene", "gene_name": "A630095N17Rik", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC381272 isoform 1", "refseq_ac": [ { "id": "NP_001230019", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001230019", "type": "external" } ], "gene_names_uniprotkb": "A630095N17Rik", "gene_names_refseq": "A630095N17Rik; Gm1624", "protein_names_uniprotkb": "RIKEN cDNA A630095N17 gene", "protein_names_refseq": "uncharacterized protein LOC381272 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:381272)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "J3KMM7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2BEI8-1", "uniprot_id": [ { "id": "A2BEI8_MOUSE", "url": "https://www.uniprot.org/uniprot/A2BEI8", "type": "external" } ], "mass": 41376.0, "length": 360, "protein_name": "Myb/SANT DNA binding domain containing 5 family member 8", "gene_name": "Msantd5f8", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC623272", "refseq_ac": [ { "id": "NP_001079007", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001079007", "type": "external" } ], "gene_names_uniprotkb": "Msantd5f8", "gene_names_refseq": "Gm11757; Msantd5f8", "protein_names_uniprotkb": "Myb/SANT DNA binding domain containing 5 family member 8", "protein_names_refseq": "uncharacterized protein LOC623272", "tax_id": 10090, "disease": "", "pathway": " (mmu:623272)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "This gene belongs to a family of related genes tandemly arranged in two clusters on chromosome 4. This family, which appears to be mouse-specific and composed of multiple highly similar members, is supported by limited transcript data. Members of the family maintain an intact open reading frame although the encoded protein has no known function. This gene is inferred from alignment of paralogous transcripts. [provided by RefSeq, Mar 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2BEI8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SP85-1", "uniprot_id": [ { "id": "CC85A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5SP85", "type": "external" } ], "mass": 54483.0, "length": 500, "protein_name": "Coiled-coil domain-containing protein 85A", "gene_name": "Ccdc85a", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 85A isoform 2", "refseq_ac": [ { "id": "NP_001160133", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160133", "type": "external" } ], "gene_names_uniprotkb": "Ccdc85a; Kiaa1912", "gene_names_refseq": "Ccdc85a", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 85A", "protein_names_refseq": "coiled-coil domain-containing protein 85A isoform 2; coiled-coil domain-containing protein 85A", "tax_id": 10090, "disease": "", "pathway": " (mmu:216613)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;24129315", "class_list": "", "function": "May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q69Z68;Q6NZL9;Q8BGZ5;Q8BLC5;Q8VCC5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005912 adherens junction", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5SP85-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80U56-1", "uniprot_id": [ { "id": "AVL9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80U56", "type": "external" } ], "mass": 72186.0, "length": 649, "protein_name": "Late secretory pathway protein AVL9 homolog", "gene_name": "Avl9", "organism": "Mouse", "refseq_name": "late secretory pathway protein AVL9 homolog", "refseq_ac": [ { "id": "NP_084511", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084511", "type": "external" } ], "gene_names_uniprotkb": "Avl9; Kiaa0241", "gene_names_refseq": "5830411G16Rik; Avl9; D730049P16Rik; mKIAA0241", "protein_names_uniprotkb": "Late secretory pathway protein AVL9 homolog", "protein_names_refseq": "AVL9 homolog (S. cerevisiase); late secretory pathway protein AVL9 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:78937)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "21183079;21750661;22645316;22872234;30084848;31219806;32782141;34428180;35822049", "class_list": "", "function": "Functions in cell migration., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q149B3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0055037 recycling endosome", "go_biological_process": "GO:0016477 cell migration", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q80U56-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80YN3-1", "uniprot_id": [ { "id": "BCAS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80YN3", "type": "external" } ], "mass": 67378.0, "length": 633, "protein_name": "Breast carcinoma-amplified sequence 1 homolog", "gene_name": "Bcas1", "organism": "Mouse", "refseq_name": "breast carcinoma-amplified sequence 1 homolog isoform 1", "refseq_ac": [ { "id": "NP_084091", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084091", "type": "external" } ], "gene_names_uniprotkb": "Bcas1; Nabc1", "gene_names_refseq": "2210416M21Rik; 9030223A09Rik; Bcas1; NABC1", "protein_names_uniprotkb": "Breast carcinoma-amplified sequence 1 homolog; Novel amplified in breast cancer 1 homolog", "protein_names_refseq": "amplified in breast cancer 1; breast carcinoma amplified sequence 1; breast carcinoma-amplified sequence 1 homolog isoform 1; breast carcinoma-amplified sequence 1 homolog; novel amplified in breast cancer 1 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:76960)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;14567997;21183079;21514331;21750661;28230289;32848054;40021952;40885482", "class_list": "", "function": "Required for myelination., [UniProtKB, PubMed]; That the loss of BCAS1 specifically induced hypomyelination and the expression of inflammation-related genes in the brain, [RefSeq, PubMed]; Two transcripts with regulation from days 7 to 28 in the 1-methyl-4-phenyl-tetrahydropyridine treated groups, are identified: brain specific angiogenesis inhibitor associated protein 3 (Baiap3) and breast carcinoma amplified sequence 1 (Bcas1)., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A2AVX2;Q9CVA1", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse", "go_biological_process": "GO:0042552 myelination", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q80YN3-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CWG9-1", "uniprot_id": [ { "id": "BL1S2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CWG9", "type": "external" } ], "mass": 16300.0, "length": 143, "protein_name": "Biogenesis of lysosome-related organelles complex 1 subunit 2", "gene_name": "Bloc1s2", "organism": "Mouse", "refseq_name": "biogenesis of lysosome-related organelles complex 1 subunit 2", "refseq_ac": [ { "id": "NP_082883", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082883", "type": "external" } ], "gene_names_uniprotkb": "Bloc1s2; Blos2", "gene_names_refseq": "2410089B13Rik; BLOS2; Bloc1s2a; Bloc1s2", "protein_names_uniprotkb": "Biogenesis of lysosome-related organelles complex 1 subunit 2; BLOC-1 subunit 2", "protein_names_refseq": "BLOC-1 subunit 2; biogenesis of lysosome-related organelles complex 1 subunit 2; biogenesis of lysosome-related organelles complex-1, subunit 2A", "tax_id": 10090, "disease": "Hermansky-Pudlak syndrome (Disease Ontology:DOID:3753)", "pathway": " (mmu:73689)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "15102850;16760431;18188704;19546860;20308062;21750661;21998198;22872234;25605945;27719760;28456747;34428180", "class_list": "", "function": "BLOS2 physically interacted with Notch1 in endo-lysosomal trafficking of Notch1. The findings suggest that BLOS2 is a novel negative player in regulating Notch signaling through lysosomal trafficking to control multiple stem and progenitor cell homeostasis in vertebrates. Publication Status: Online-Only, [RefSeq, PubMed]; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes (By similarity). In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (PubMed:16760431, PubMed:21998198). The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension (PubMed:19546860). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Mutations in the human genes encoding Snapin and the BLOS proteins could underlie novel forms of Hermansky-Pudlak syndrome as seen in mouse models, [RefSeq, PubMed]; These findings reveal that balanced control of Notch signaling by BLOS2 is required for HSC homeostasis during fetal liver hematopoiesis. Erratum:[Exp Hematol. 2017 Oct;54:51. doi: 10.1016/j.exphem.2017.06.350. PMID: 28732189], [RefSeq, PubMed]; WASH is a bimodular protein and a component of the BLOC-1 complex in which the C terminus is involved in Arp2/3-mediated actin nucleation, whereas the N-terminal portion is required for its regulation and localization in the cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ATZ7;Q6P062", "ec_number_list": [], "go_molecular_function": "GO:0043015 gamma-tubulin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005813 centrosome;GO:0005829 cytosol;GO:0055037 recycling endosome", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0031175 neuron projection development;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0016197 endosomal transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9CWG9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VHW2-1", "uniprot_id": [ { "id": "CCG8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VHW2", "type": "external" } ], "mass": 43453.0, "length": 423, "protein_name": "Voltage-dependent calcium channel gamma-8 subunit", "gene_name": "Cacng8", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cacng8", "gene_names_refseq": "", "protein_names_uniprotkb": "Voltage-dependent calcium channel gamma-8 subunit; Neuronal voltage-gated calcium channel gamma-8 subunit; TARP gamma-8; Transmembrane AMPAR regulatory protein gamma-8", "protein_names_refseq": "", "tax_id": 10090, "disease": "antisocial personality disorder (Disease Ontology:DOID:10939); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (mmu:81905); (R-MMU-399719); (R-MMU-5576892); (R-MMU-5576893); (R-MMU-5682910)", "pathway_count": 5, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;11738816;17114649;21127204;21172611;21183079;21750661;22517741;33981040;34678516;40021952;40885482", "class_list": "", "function": "Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (PubMed:21127204). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state., [UniProtKB, PubMed, PubMed]; Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005246 calcium channel regulator activity;GO:0030346 protein phosphatase 2B binding;GO:0005245 voltage-gated calcium channel activity;GO:0035255 ionotropic glutamate receptor binding;GO:0016247 channel regulator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0014069 postsynaptic density;GO:0045211 postsynaptic membrane;GO:0032281 AMPA glutamate receptor complex;GO:0032590 dendrite membrane", "go_biological_process": "GO:0051968 positive regulation of synaptic transmission, glutamatergic;GO:2000969 positive regulation of AMPA receptor activity;GO:0019226 transmission of nerve impulse;GO:2000311 regulation of AMPA receptor activity;GO:0098970 postsynaptic neurotransmitter receptor diffusion trapping", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q8VHW2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NZQ0-1", "uniprot_id": [ { "id": "CF119_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6NZQ0", "type": "external" } ], "mass": 37873.0, "length": 333, "protein_name": "Cilia- and flagella-associated protein 119", "gene_name": "Cfap119", "organism": "Mouse", "refseq_name": "cilia- and flagella-associated protein 119 isoform 1", "refseq_ac": [ { "id": "NP_001028212", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028212", "type": "external" } ], "gene_names_uniprotkb": "Cfap119; Ccdc189; Gm166", "gene_names_refseq": "Ccdc189; Cfap119; Gm166", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 119; Coiled-coil domain-containing protein 189", "protein_names_refseq": "cilia- and flagella-associated protein 119 isoform 1; coiled-coil domain containing 189; coiled-coil domain-containing protein 189", "tax_id": 10090, "disease": "", "pathway": " (mmu:233899)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21183079;21750661;22872234;39018224", "class_list": "", "function": "CCDC189 depletion leads to oligo-astheno-teratozoospermia and male infertility in micedagger., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UST8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0001534 radial spoke;GO:0005737 cytoplasm;GO:0001669 acrosomal vesicle;GO:0005930 axoneme;GO:0097228 sperm principal piece", "go_biological_process": "GO:0007338 single fertilization;GO:0010467 gene expression;GO:0120316 sperm flagellum assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6NZQ0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35762-1", "uniprot_id": [ { "id": "CD81_MOUSE", "url": "https://www.uniprot.org/uniprot/P35762", "type": "external" } ], "mass": 25815.0, "length": 236, "protein_name": "CD81 antigen", "gene_name": "Cd81", "organism": "Mouse", "refseq_name": "CD81 antigen", "refseq_ac": [ { "id": "NP_598416", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598416", "type": "external" } ], "gene_names_uniprotkb": "Cd81; Tapa1", "gene_names_refseq": "Cd81; Tapa-1; Tapa1; Tspan28", "protein_names_uniprotkb": "CD81 antigen; 26 kDa cell surface protein TAPA-1; Target of the antiproliferative antibody 1", "protein_names_refseq": "26 kDa cell surface protein TAPA-1; CD81 antigen; target of the antiproliferative antibody 1", "tax_id": 10090, "disease": "common variable immunodeficiency 6 (Disease Ontology:DOID:0081149)", "pathway": " (mmu:12520); (R-MMU-198933); (R-MMU-977606)", "pathway_count": 3, "publication_count": 23, "publication_id_list": "10915772;11046035;11673522;12483205;12796480;16380109;16395393;1650385;17290409;18662991;20579434;21750661;23213457;23499492;23575678;23665349;26116703;30084848;33300544;34428180;35764142;37339209;39140770", "class_list": "", "function": "(Microbial infection) Specifically required for Plasmodium yoelii infectivity of hepatocytes, controlling sporozoite entry in hepatocytes via the parasitophorous vacuole and subsequent parasite differentiation to exoerythrocytic forms., [UniProtKB, PubMed]; CD81 fusion alters SARS-CoV-2 Spike trafficking., [RefSeq, PubMed]; CD81 gene is maternally imprinted, with preferential expression from the paternal allele., [RefSeq, PubMed]; Chronic knockdown of the tetraspanin gene CD81 in the mouse nucleus accumbens modulates anxiety and ethanol-related behaviors., [RefSeq, PubMed]; Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalization of CD19 receptor on the cell surface of activated B cells (PubMed:23499492). Upon initial encounter with a microbial pathogen, enables the assembly of CD19-CR2 and B cell receptor complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and humoral immune response (By similarity). In T cells, associates with CD4 or CD8 coreceptors and defines the maturation state of antigen-induced synapses with B cells (By similarity). Facilitates localization of CD3 in these immune synapses, required for costimulation and sustained activation of T cells, preferentially triggering T helper type 2 immune response (PubMed:11046035). Can act both as positive and negative regulator of homotypic or heterotypic cell-cell fusion processes. In myoblasts, associates with another tetraspanin CD9 in complex with PTGFRN and inhibits myotube fusion during muscle regeneration (PubMed:23575678). In macrophages, associates with CD9 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles. Also prevents the fusion between mononuclear cell progenitors into osteoclasts in charge of bone resorption. Positively regulates sperm-egg fusion and may be involved in the acrosome reaction (PubMed:16380109, PubMed:17290409). Regulates protein trafficking in intracellular compartments. In T cells, associates with dNTPase SAMHD1 and defines its subcellular location, enabling its degradation by the proteasome and thereby controlling intracellular dNTP levels (By similarity). Also regulates integrin-dependent migration of macrophages, particularly relevant for inflammatory response in the lung (PubMed:18662991)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; The molecular mechanism of CD81 antibody inhibition of metastasis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91V78", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0015485 cholesterol binding;GO:0001618 virus receptor activity;GO:1990459 transferrin receptor binding;GO:0042289 MHC class II protein binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0070062 extracellular exosome", "go_biological_process": "GO:1903911 positive regulation of receptor clustering;GO:0031623 receptor internalization;GO:0042127 regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P35762-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WVC3-1", "uniprot_id": [ { "id": "CAV2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WVC3", "type": "external" } ], "mass": 18227.0, "length": 162, "protein_name": "Caveolin-2", "gene_name": "Cav2", "organism": "Mouse", "refseq_name": "caveolin-2 isoform 1", "refseq_ac": [ { "id": "NP_058596", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058596", "type": "external" } ], "gene_names_uniprotkb": "Cav2", "gene_names_refseq": "Cav2", "protein_names_uniprotkb": "Caveolin-2", "protein_names_refseq": "caveolin-2 isoform 1", "tax_id": 10090, "disease": "tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); primary open angle glaucoma (Disease Ontology:DOID:1070); low tension glaucoma (Disease Ontology:DOID:13544); high grade glioma (Disease Ontology:DOID:3070); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:12390); (R-MMU-9009391)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "10373486;12054493;12091389;15504032;17242355;21183079;21750661;24067367;25428507;27802388;31156619;33649389;34428180;35820727;36572563;37828378;39038612", "class_list": "", "function": "Caveolin-2 controls preadipocyte survival in the mitotic clonal expansion for adipogenesis., [RefSeq, PubMed]; Increased Caveolin-2 Expression in Brain Endothelial Cells Promotes Age-Related Neuroinflammation., [RefSeq, PubMed]; May act as a scaffolding protein within caveolar membranes. Interacts directly with G protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity)., [UniProtKB]; Splice variant of mouse caveolin-2 mRNA, encoding an isoform lacking the C-terminal domain, localized to the endoplasmic reticulum, while the authentic caveolin-2 was distributed to the Golgi and the plasma membrane along with caveolin-1., [RefSeq, PubMed]; This gene belongs to the caveolin family whose members encode the major protein components of caveolae, which are invaginations of plasma membrane. This gene is located adjacent to caveolin-1 and the proteins coexpressed by the two genes localize together in caveolae, where they form hetero-oligomers. The encoded protein may be involved in diverse cellular functions including proliferation, differentiation, endocytosis and trafficking. Alternative splicing of this gene results in transcript variants encoding different isoforms. [provided by RefSeq, Apr 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TYR4", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019901 protein kinase binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005635 nuclear envelope;GO:0005794 Golgi apparatus;GO:0005811 lipid droplet;GO:0005886 plasma membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0007186 G protein-coupled receptor signaling pathway;GO:0008285 negative regulation of cell population proliferation;GO:0030154 cell differentiation;GO:0043410 positive regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9WVC3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51943-1", "uniprot_id": [ { "id": "CCNA2_MOUSE", "url": "https://www.uniprot.org/uniprot/P51943", "type": "external" } ], "mass": 47269.0, "length": 422, "protein_name": "Cyclin-A2", "gene_name": "Ccna2", "organism": "Mouse", "refseq_name": "cyclin-A2", "refseq_ac": [ { "id": "NP_033958", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033958", "type": "external" } ], "gene_names_uniprotkb": "Ccna2; Ccna; Cyca2; Cyca", "gene_names_refseq": "Ccn-1; Ccn1; Ccna2; Ccna; CycA2; Cyca", "protein_names_uniprotkb": "Cyclin-A2; Cyclin-A", "protein_names_refseq": "Cyclin A2 (Cyclin A); cyclin-A2; cyclin-A", "tax_id": 10090, "disease": "embryonal carcinoma (Disease Ontology:DOID:3308); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (mmu:12428); (R-MMU-1538133); (R-MMU-171319); (R-MMU-174184); (R-MMU-176408); (R-MMU-187577); (R-MMU-2559582); (R-MMU-2559586); (R-MMU-5689880); (R-MMU-5693607); (R-MMU-6804116); (R-MMU-6804756); (R-MMU-6804757); (R-MMU-68911); (R-MMU-68949); (R-MMU-69017); (R-MMU-69273); (R-MMU-69478); (R-MMU-69563); (R-MMU-69656); (R-MMU-75035)", "pathway_count": 21, "publication_count": 15, "publication_id_list": "10068472;20173027;21750661;22872234;25428506;30084848;30779550;31219806;32973148;33649389;34203471;34428180;35820727;8565853;8575639", "class_list": "", "function": "Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle., [UniProtKB, UniProtKB]; Essential for the control of the cell cycle at G1/S and G2/M transition (By similarity). Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q61459;Q8BRG1", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005815 microtubule organizing center", "go_biological_process": "GO:0043687 post-translational protein modification;GO:0051301 cell division;GO:0000086 G2/M transition of mitotic cell cycle;GO:0071456 cellular response to hypoxia;GO:0007265 Ras protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P51943-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O09165-1", "uniprot_id": [ { "id": "CASQ1_MOUSE", "url": "https://www.uniprot.org/uniprot/O09165", "type": "external" } ], "mass": 46378.0, "length": 405, "protein_name": "Calsequestrin-1", "gene_name": "Casq1", "organism": "Mouse", "refseq_name": "calsequestrin-1 precursor", "refseq_ac": [ { "id": "NP_033943", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033943", "type": "external" } ], "gene_names_uniprotkb": "Casq1", "gene_names_refseq": "CSQ-1; CSQ1; CSQ; Casq1; sCSQ", "protein_names_uniprotkb": "Calsequestrin-1; Calmitine; Calsequestrin, skeletal muscle isoform", "protein_names_refseq": "calmitine; calsequestrin-1 precursor", "tax_id": 10090, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:12372); (R-MMU-2672351); (R-MMU-5578775)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "17627988;21750661;22049211;34203471;36222861;39927985;7945294;9795116", "class_list": "", "function": "Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions (By similarity). Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction. Negatively regulates store-operated Ca(2+) entry (SOCE) activity (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Constitutive assembly of Ca2+ entry units in soleus muscle from calsequestrin knockout mice., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005783 endoplasmic reticulum;GO:0031674 I band;GO:0042383 sarcolemma", "go_biological_process": "GO:1901341 positive regulation of store-operated calcium channel activity;GO:0051281 positive regulation of release of sequestered calcium ion into cytosol;GO:0014894 response to denervation involved in regulation of muscle adaptation;GO:0045214 sarcomere organization;GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O09165-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O55187-1", "uniprot_id": [ { "id": "CBX4_MOUSE", "url": "https://www.uniprot.org/uniprot/O55187", "type": "external" } ], "mass": 60523.0, "length": 551, "protein_name": "E3 SUMO-protein ligase CBX4", "gene_name": "Cbx4", "organism": "Mouse", "refseq_name": "E3 SUMO-protein ligase CBX4", "refseq_ac": [ { "id": "NP_031651", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031651", "type": "external" } ], "gene_names_uniprotkb": "Cbx4; Pc2", "gene_names_refseq": "Cbx4; MPc2; PC2", "protein_names_uniprotkb": "E3 SUMO-protein ligase CBX4; 2.3.2.-; Chromobox protein homolog 4; E3 SUMO-protein transferase CBX4; Pc2; Polycomb 2 homolog; mPc2", "protein_names_refseq": "E3 SUMO-protein ligase CBX4; E3 SUMO-protein transferase CBX4; chromobox homolog 4; chromobox protein homolog 4; polycomb 2 homolog", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:12418); (R-MMU-3108214); (R-MMU-3899300); (R-MMU-4551638); (R-MMU-4570464); (R-MMU-8939243); (R-MMU-8943724)", "pathway_count": 7, "publication_count": 10, "publication_id_list": "16537902;22226355;22872859;29539416;34428180;37348765;37486206;37691307;37696812;9367786", "class_list": "", "function": "CBX4 deletion promotes tumorigenesis under Kras[G12D] background by inducing genomic instability. Publication Status: Online-Only, [RefSeq, PubMed]; CBX4 promotes antitumor immunity by suppressing Pdcd1 expression in T cells., [RefSeq, PubMed]; Cbx4 governs HIF-1alpha to involve in Th9 cell differentiation promoting asthma by its SUMO E3 ligase activity., [RefSeq, PubMed]; Cutting Edge: Polycomb Repressive Complex 1 Subunit Cbx4 Positively Regulates Effector Responses in CD8 T Cells., [RefSeq, PubMed]; E3 SUMO-protein ligase that catalyzes sumoylation of target proteins by promoting the transfer of SUMO from the E2 enzyme to the substrate (PubMed:29539416). Also acts as a histone reader, which specifically recognizes and binds histone H3 trimethylated at 'Lys-9' and 'Lys-27' (H3K9me3 and H3K27me3, respectively) via its chromo domain (PubMed:16537902, PubMed:29539416). Catalyzes sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression (By similarity). Acts as a regulator of brown adipocyte differentiation by mediating sumoylation of PRDM16, thereby preventing PRDM16 ubiquitination and degradation (PubMed:29539416). Monosumoylates ZNF131 (By similarity). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (By similarity). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (PubMed:22226355)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q149G5;Q149G6", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.37", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "2.1.1.367", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.367", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "2.1.1.356", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.356", "type": "external" }, { "id": "2.3.1.57", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.57", "type": "external" } ], "go_molecular_function": "GO:0061665 SUMO ligase activity;GO:0003682 chromatin binding;GO:0019899 enzyme binding;GO:0051219 phosphoprotein binding;GO:0003727 single-stranded RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0016604 nuclear body;GO:0031519 PcG protein complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0016925 protein sumoylation;GO:0045892 negative regulation of DNA-templated transcription;GO:0050821 protein stabilization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O55187-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88602-1", "uniprot_id": [ { "id": "CCG2_MOUSE", "url": "https://www.uniprot.org/uniprot/O88602", "type": "external" } ], "mass": 35895.0, "length": 323, "protein_name": "Voltage-dependent calcium channel gamma-2 subunit", "gene_name": "Cacng2", "organism": "Mouse", "refseq_name": "voltage-dependent calcium channel gamma-2 subunit", "refseq_ac": [ { "id": "NP_031609", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031609", "type": "external" } ], "gene_names_uniprotkb": "Cacng2; Stg", "gene_names_refseq": "B230105C07Rik; B930041E13Rik; Cacng2; stargazer; stargazin; stg; waggler; wag", "protein_names_uniprotkb": "Voltage-dependent calcium channel gamma-2 subunit; Neuronal voltage-gated calcium channel gamma-2 subunit; Stargazin; TARP gamma-2; Transmembrane AMPAR regulatory protein gamma-2", "protein_names_refseq": "TARP gamma-2; neuronal voltage-gated calcium channel gamma-2 subunit; transmembrane AMPAR regulatory protein gamma-2; voltage-dependent calcium channel gamma-2 subunit", "tax_id": 10090, "disease": "autosomal dominant intellectual developmental disorder 10 (Disease Ontology:DOID:0070040); childhood absence epilepsy (Disease Ontology:DOID:1825)", "pathway": " (mmu:12300); (R-MMU-112308); (R-MMU-399719); (R-MMU-5682910)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "11805122;15136571;18034455;31219806;37491367;9697694", "class_list": "", "function": "Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; TARPgamma2 Is Required for Normal AMPA Receptor Expression and Function in Direction-Selective Circuits of the Mammalian Retina. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005245 voltage-gated calcium channel activity;GO:0035255 ionotropic glutamate receptor binding;GO:0016247 channel regulator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0009986 cell surface;GO:0032281 AMPA glutamate receptor complex;GO:0036477 somatodendritic compartment;GO:0044300 cerebellar mossy fiber", "go_biological_process": "GO:1904510 positive regulation of protein localization to basolateral plasma membrane;GO:0007528 neuromuscular junction development;GO:0042391 regulation of membrane potential;GO:0051592 response to calcium ion;GO:0006612 protein targeting to membrane", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O88602-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47774-1", "uniprot_id": [ { "id": "CCR7_MOUSE", "url": "https://www.uniprot.org/uniprot/P47774", "type": "external" } ], "mass": 42856.0, "length": 378, "protein_name": "C-C chemokine receptor type 7", "gene_name": "Ccr7", "organism": "Mouse", "refseq_name": "C-C chemokine receptor type 7 isoform b", "refseq_ac": [ { "id": "NP_001288642", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001288642", "type": "external" } ], "gene_names_uniprotkb": "Ccr7; Cmkbr7; Ebi1h; Ebi1", "gene_names_refseq": "CC-CKR-7; CCR-7; CD197; Ccr7; Cdw197; Cmkbr7; EBI1; Ebi1h", "protein_names_uniprotkb": "C-C chemokine receptor type 7; C-C CKR-7; CC-CKR-7; CCR-7; EBI1; EBV-induced G protein-coupled receptor 1; Epstein-Barr virus-induced G protein-coupled receptor 1; MIP-3 beta receptor", "protein_names_refseq": "C-C chemokine receptor type 7 isoform b; C-C chemokine receptor type 7; EBV-induced G-protein coupled receptor 1; MIP-3 beta receptor; chemokine (C-C motif) receptor 7; chemokine (C-C) receptor 7; epstein-Barr virus-induced G-protein coupled receptor 1", "tax_id": 10090, "disease": "Sjogren's syndrome (Disease Ontology:DOID:12894); pulmonary sarcoidosis (Disease Ontology:DOID:13406); pneumonia (Disease Ontology:DOID:552)", "pathway": " (mmu:12775); (R-MMU-380108); (R-MMU-418594)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "26495903;36210013;7851893", "class_list": "", "function": "Receptor for the MIP-3-beta chemokine., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8CAS2", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0016493 C-C chemokine receptor activity;GO:0035757 chemokine (C-C motif) ligand 19 binding;GO:0035758 chemokine (C-C motif) ligand 21 binding;GO:0038117 C-C motif chemokine 19 receptor activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0032651 regulation of interleukin-1 beta production;GO:0006935 chemotaxis;GO:0006954 inflammatory response;GO:0006955 immune response;GO:0007204 positive regulation of cytosolic calcium ion concentration", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P47774-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P60766-2", "uniprot_id": [ { "id": "CDC42_MOUSE", "url": "https://www.uniprot.org/uniprot/P60766", "type": "external" } ], "mass": 21259.0, "length": 191, "protein_name": "Cell division control protein 42 homolog", "gene_name": "Cdc42", "organism": "Mouse", "refseq_name": "cell division control protein 42 homolog isoform 2", "refseq_ac": [ { "id": "NP_001230698", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001230698", "type": "external" } ], "gene_names_uniprotkb": "Cdc42", "gene_names_refseq": "Cdc42", "protein_names_uniprotkb": "Cell division control protein 42 homolog; 3.6.5.2; G25K GTP-binding protein", "protein_names_refseq": "G25K GTP-binding protein; cell division control protein 42 homolog isoform 2; cell division control protein 42 homolog; cell division cycle 42 homolog", "tax_id": 10090, "disease": "cerebral cavernous malformation (Disease Ontology:DOID:0060669); microvillus inclusion disease (Disease Ontology:DOID:0060775); Alzheimer's disease (Disease Ontology:DOID:10652); pancreatic cancer (Disease Ontology:DOID:1793); syndrome (Disease Ontology:DOID:225); bipolar disorder (Disease Ontology:DOID:3312); temporal lobe epilepsy (Disease Ontology:DOID:3328); fibrosarcoma (Disease Ontology:DOID:3355); rhinitis (Disease Ontology:DOID:4483); myelofibrosis (Disease Ontology:DOID:4971); kidney disease (Disease Ontology:DOID:557); cleft palate (Disease Ontology:DOID:674)", "pathway": " (mmu:12540); (R-MMU-114604); (R-MMU-182971); (R-MMU-2029482); (R-MMU-389359); (R-MMU-3928662); (R-MMU-418885); (R-MMU-4420097); (R-MMU-525793); (R-MMU-5625970); (R-MMU-5626467); (R-MMU-5627123); (R-MMU-5663213); (R-MMU-5663220); (R-MMU-5687128); (R-MMU-8964616); (R-MMU-9013148); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013406); (R-MMU-9013408); (R-MMU-9013420); (R-MMU-9013423); (R-MMU-9013424); (R-MMU-983231); (R-MMU-9958810); (R-MMU-9958825)", "pathway_count": 27, "publication_count": 22, "publication_id_list": "10490598;10934474;12773384;14506284;15710388;16968698;17000758;22461490;22494997;24352656;25851601;26495903;26969129;30185885;34428180;37453647;37507081;39927985;8464478;8954774;9224952;9535835", "class_list": "", "function": "Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state (PubMed:24352656). In its active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration (By similarity). In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons (PubMed:25851601). Facilitates filopodia formation upon DOCK11-activation (PubMed:22494997). Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling (By similarity). Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups (By similarity). Upon activation by PLEKHG4B, involved in actin cytoskeletal remodeling during epithelial cell-cell junction formation (By similarity). Negatively regulates polymerization of SEPTIN12, as a result may be involved in spermatogenesis (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A9U6;P21181;P25763;Q3THZ7;Q3TJK6;Q545V0;Q6P201;Q8BQ51", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.3", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "1.13.11.20", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.20", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "1.3.1.70", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.70", "type": "external" }, { "id": "1.6.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.-", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "1.16.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.1.-", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.2.1", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding;GO:0034191 apolipoprotein A-I receptor binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0086100 endothelin receptor signaling pathway;GO:0006468 protein phosphorylation;GO:0006897 endocytosis;GO:0006911 phagocytosis, engulfment;GO:0007015 actin filament organization", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P60766-2", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D6J3-1", "uniprot_id": [ { "id": "YJU2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D6J3", "type": "external" } ], "mass": 35988.0, "length": 314, "protein_name": "Splicing factor YJU2", "gene_name": "Yju2", "organism": "Mouse", "refseq_name": "splicing factor YJU2", "refseq_ac": [ { "id": "NP_082657", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082657", "type": "external" } ], "gene_names_uniprotkb": "Yju2; Ccdc94; YJU2", "gene_names_refseq": "2900016D05Rik; Ccdc94; Yju2", "protein_names_uniprotkb": "Splicing factor YJU2; Coiled-coil domain-containing protein 94", "protein_names_refseq": "YJU2 splicing factor homolog; coiled-coil domain containing 94; coiled-coil domain-containing protein 94; splicing factor YJU2", "tax_id": 10090, "disease": "", "pathway": " (mmu:72886); (R-MMU-72163)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "17242355;19131326;21183079;21750661;31219806", "class_list": "", "function": "Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005681 spliceosomal complex;GO:0071006 U2-type catalytic step 1 spliceosome", "go_biological_process": "GO:0000349 generation of catalytic spliceosome for first transesterification step;GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator;GO:0045292 mRNA cis splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9D6J3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DA73-1", "uniprot_id": [ { "id": "CCD89_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DA73", "type": "external" } ], "mass": 43241.0, "length": 370, "protein_name": "Coiled-coil domain-containing protein 89", "gene_name": "Ccdc89", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 89", "refseq_ac": [ { "id": "NP_081574", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081574", "type": "external" } ], "gene_names_uniprotkb": "Ccdc89; Boip", "gene_names_refseq": "1700019B01Rik; BOIP; Ccdc89", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 89; Bc8 orange-interacting protein", "protein_names_refseq": "bc8 orange-interacting protein; coiled-coil domain-containing protein 89", "tax_id": 10090, "disease": "", "pathway": " (mmu:70054)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "14648848;21183079", "class_list": "", "function": "BOIP is a novel cDNA highly expressed during spermatogenesis that encodes a protein interacting with the orange domain of the hairy-related transcription factor HRT1/Hey1 in Xenopus and mouse [BOIP], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9DA73-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UHL1-1", "uniprot_id": [ { "id": "CAMKV_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UHL1", "type": "external" } ], "mass": 54819.0, "length": 512, "protein_name": "CaM kinase-like vesicle-associated protein", "gene_name": "Camkv", "organism": "Mouse", "refseq_name": "caM kinase-like vesicle-associated protein", "refseq_ac": [ { "id": "NP_663596", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663596", "type": "external" } ], "gene_names_uniprotkb": "Camkv", "gene_names_refseq": "1G5; Camkv", "protein_names_uniprotkb": "CaM kinase-like vesicle-associated protein", "protein_names_refseq": "caM kinase-like vesicle-associated protein; vesicle-associated calmodulin-binding protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:235604)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "15345747;21183079;21750661;22517741;27796283;32848054;33300544;40021952;40885482", "class_list": "", "function": "Camkv has a role in activity-dependent maintenance of dendritic spines Publication Status: Online-Only, [RefSeq, PubMed]; Does not appear to have detectable kinase activity., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q8VD20", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0004683 calcium/calmodulin-dependent protein kinase activity;GO:0004672 protein kinase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0045202 synapse;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0050804 modulation of chemical synaptic transmission;GO:0099159 regulation of modification of postsynaptic structure", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q3UHL1-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CS00-1", "uniprot_id": [ { "id": "CATIN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CS00", "type": "external" } ], "mass": 90661.0, "length": 772, "protein_name": "Splicing factor Cactin", "gene_name": "Cactin", "organism": "Mouse", "refseq_name": "splicing factor Cactin", "refseq_ac": [ { "id": "NP_081657", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081657", "type": "external" } ], "gene_names_uniprotkb": "Cactin", "gene_names_refseq": "2510012J08Rik; Cactin", "protein_names_uniprotkb": "Splicing factor Cactin", "protein_names_refseq": "splicing factor Cactin", "tax_id": 10090, "disease": "", "pathway": " (mmu:70312); (R-MMU-72163)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "17242355;20829348;21183079;21750661;31599954", "class_list": "", "function": "Plays a role in pre-mRNA splicing by facilitating excision of a subset of introns (By similarity). Required for the splicing of CDCA5/Sororin, a regulator of sister chromatid cohesion (By similarity). Involved in the regulation of innate immune response (By similarity). Acts as a negative regulator of Toll-like receptor, interferon-regulatory factor (IRF) and canonical NF-kappa-B signaling pathways (By similarity). Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous pro-inflammatory stimuli (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0045087 innate immune response;GO:0001933 negative regulation of protein phosphorylation;GO:0032720 negative regulation of tumor necrosis factor production;GO:0071222 cellular response to lipopolysaccharide;GO:0043124 negative regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CS00-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08738-1", "uniprot_id": [ { "id": "CASP6_MOUSE", "url": "https://www.uniprot.org/uniprot/O08738", "type": "external" } ], "mass": 31595.0, "length": 276, "protein_name": "Caspase-6", "gene_name": "Casp6", "organism": "Mouse", "refseq_name": "caspase-6 precursor", "refseq_ac": [ { "id": "NP_033941", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033941", "type": "external" } ], "gene_names_uniprotkb": "Casp6; Mch2", "gene_names_refseq": "CASP-6; Casp6; Mch2", "protein_names_uniprotkb": "Caspase-6; 3.4.22.59; Apoptotic protease Mch-2; CASP-6", "protein_names_refseq": "apoptotic protease Mch-2; caspase-6 precursor", "tax_id": 10090, "disease": "ductal carcinoma in situ (Disease Ontology:DOID:0060074); endometritis (Disease Ontology:DOID:1002); prostate carcinoma (Disease Ontology:DOID:10286); Alzheimer's disease (Disease Ontology:DOID:10652); prostatic hypertrophy (Disease Ontology:DOID:11132); status epilepticus (Disease Ontology:DOID:1824); brain ischemia (Disease Ontology:DOID:2316); middle cerebral artery infarction (Disease Ontology:DOID:3525); lung non-small cell carcinoma (Disease Ontology:DOID:3908); ovarian carcinoma (Disease Ontology:DOID:4001); chronic myeloid leukemia (Disease Ontology:DOID:8552)", "pathway": " (mmu:12368); (R-MMU-111465); (R-MMU-264870); (R-MMU-352238)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "11062535;18981099;21183079;22555455;23695670;25231987;29863787;32029622;32298652;34428180;35922005;37828624;38040383;9038361", "class_list": "", "function": "(Microbial infection) Proteolytically cleaves the N protein of coronaviruses. The cleavage leads to two fragments and modulates coronavirus replication by regulating IFN signaling. The two fragments produced by the cleavage interact with IRF3 inhibiting its nuclear translocation after activation and reduce the expression of IFNB and IFN-stimulated genes., [UniProtKB, PubMed]; Antisense oligonucleotide-mediated disruption of HTT caspase-6 cleavage site ameliorates the phenotype of YAC128 Huntington disease mice., [RefSeq, PubMed]; Caspase 6 promotes innate immune activation by functional crosstalk between RIPK1-IkappaBalpha axis in liver inflammation. Publication Status: Online-Only, [RefSeq, PubMed]; Cysteine protease that plays essential roles in programmed cell death, axonal degeneration, development and innate immunity (PubMed:18981099, PubMed:22555455, PubMed:23695670, PubMed:32298652). Acts as a non-canonical executioner caspase during apoptosis: localizes in the nucleus and cleaves the nuclear structural protein NUMA1 and lamin A/LMNA thereby inducing nuclear shrinkage and fragmentation (By similarity). Lamin-A/LMNA cleavage is required for chromatin condensation and nuclear disassembly during apoptotic execution (By similarity). Acts as a regulator of liver damage by promoting hepatocyte apoptosis: in absence of phosphorylation by AMP-activated protein kinase (AMPK), catalyzes cleavage of BID, leading to cytochrome c release, thereby participating in nonalcoholic steatohepatitis (PubMed:32029622). Cleaves PARK7/DJ-1 in cells undergoing apoptosis (PubMed:22555455). Involved in intrinsic apoptosis by mediating cleavage of RIPK1 (By similarity). Furthermore, cleaves many transcription factors such as NF-kappa-B and cAMP response element-binding protein/CREBBP (By similarity). Cleaves phospholipid scramblase proteins XKR4 and XKR9 (PubMed:25231987). In addition to apoptosis, involved in different forms of programmed cell death (PubMed:32298652). Plays an essential role in defense against viruses by acting as a central mediator of the ZBP1-mediated pyroptosis, apoptosis, and necroptosis (PANoptosis), independently of its cysteine protease activity (PubMed:32298652). PANoptosis is a unique inflammatory programmed cell death, which provides a molecular scaffold that allows the interactions and activation of machinery required for inflammasome/pyroptosis, apoptosis and necroptosis (PubMed:32298652). Mechanistically, interacts with RIPK3 and enhances the interaction between RIPK3 and ZBP1, leading to ZBP1-mediated inflammasome activation and cell death (PubMed:32298652). Plays an essential role in axon degeneration during axon pruning which is the remodeling of axons during neurogenesis but not apoptosis (PubMed:23695670). Regulates B-cell programs both during early development and after antigen stimulation (PubMed:18981099, PubMed:29863787)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes a member of the cysteine proteases that plays important roles in regulating apoptosis and neurodegeneration. The encoded protein is involved in the transmission of pain and axonal degeneration. Genetic deletion of this gene in mice results in the delay of axon pruning and protects from axon degeneration. [provided by RefSeq, Apr 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.22.59", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.59", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0042802 identical protein binding;GO:0004197 cysteine-type endopeptidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0002525 acute inflammatory response to non-antigenic stimulus;GO:0046670 positive regulation of retinal cell programmed cell death;GO:0006508 proteolysis;GO:0030855 epithelial cell differentiation;GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "O08738-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54724-1", "uniprot_id": [ { "id": "CAVN1_MOUSE", "url": "https://www.uniprot.org/uniprot/O54724", "type": "external" } ], "mass": 43954.0, "length": 392, "protein_name": "Caveolae-associated protein 1", "gene_name": "Cavin1", "organism": "Mouse", "refseq_name": "caveolae-associated protein 1 isoform 1", "refseq_ac": [ { "id": "NP_033012", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033012", "type": "external" } ], "gene_names_uniprotkb": "Cavin1; Ptrf", "gene_names_refseq": "2310075E07Rik; Cav-p60; Cavin1; Cavin; Ptrf", "protein_names_uniprotkb": "Caveolae-associated protein 1; Cav-p60; Cavin-1; Polymerase I and transcript release factor", "protein_names_refseq": "caveolae-associated protein 1 isoform 1; caveolae-associated protein 1; cavin-1; polymerase I and transcript release factor", "tax_id": 10090, "disease": "congenital generalized lipodystrophy type 4 (Disease Ontology:DOID:0111138); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (mmu:19285); (R-MMU-73863); (R-MMU-8980692); (R-MMU-9013026); (R-MMU-9013106)", "pathway_count": 5, "publication_count": 32, "publication_id_list": "10589839;10727401;11139612;11161808;15592455;17242355;18056712;18191225;18840361;19131326;19546242;21183079;21282370;23652019;25514038;25588833;26740625;27528195;29977243;30188967;31219806;31599954;33087586;33568658;34428180;36288343;37235502;37507081;37828378;38182755;39927985;9582279", "class_list": "", "function": "Cavin1 intrinsically disordered domains are essential for fuzzy electrostatic interactions and caveola formation. Publication Status: Online-Only, [RefSeq, PubMed]; Decoding the transcriptome of muscular dystrophy due to Ptrf deficiency using single-nucleus RNA sequencing., [RefSeq, PubMed]; Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues (PubMed:18056712, PubMed:18191225, PubMed:18840361, PubMed:30188967). Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1) (PubMed:19546242). Essential for normal oligomerization of CAV1 (PubMed:23652019). Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop (PubMed:27528195). Dissociates transcription complexes paused by DNA-bound TTF1, thereby releasing both RNA polymerase I and pre-RNA from the template (PubMed:10589839, PubMed:11139612, PubMed:9582279). The caveolae biogenesis pathway is required for the secretion of proteins such as GASK1A (PubMed:30188967)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Polymerase I and transcript release factor transgenic mice show impaired function of hematopoietic stem cells., [RefSeq, PubMed]; The Cavin-1/Caveolin-1 interaction attenuates BMP/Smad signaling in pulmonary hypertension by interfering with BMPR2/Caveolin-1 binding. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 22, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q2TAW6", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042134 rRNA primary transcript binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0009303 rRNA transcription;GO:0009306 protein secretion;GO:2000147 positive regulation of cell motility;GO:0006361 transcription initiation at RNA polymerase I promoter;GO:0006363 termination of RNA polymerase I transcription", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "O54724-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10810-1", "uniprot_id": [ { "id": "CD14_MOUSE", "url": "https://www.uniprot.org/uniprot/P10810", "type": "external" } ], "mass": 39204.0, "length": 366, "protein_name": "Monocyte differentiation antigen CD14", "gene_name": "Cd14", "organism": "Mouse", "refseq_name": "monocyte differentiation antigen CD14 precursor", "refseq_ac": [ { "id": "NP_033971", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033971", "type": "external" } ], "gene_names_uniprotkb": "Cd14", "gene_names_refseq": "Cd14", "protein_names_uniprotkb": "Monocyte differentiation antigen CD14; Myeloid cell-specific leucine-rich glycoprotein", "protein_names_refseq": "monocyte differentiation antigen CD14 precursor; monocyte differentiation antigen CD14; myeloid cell-specific leucine-rich glycoprotein", "tax_id": 10090, "disease": "metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); Hirschsprung's disease (Disease Ontology:DOID:10487); celiac disease (Disease Ontology:DOID:10608); hypertension (Disease Ontology:DOID:10763); sarcoidosis (Disease Ontology:DOID:11335); allergic disease (Disease Ontology:DOID:1205); primary biliary cholangitis (Disease Ontology:DOID:12236); cholestasis (Disease Ontology:DOID:13580); obstructive jaundice (Disease Ontology:DOID:13603); biliary atresia (Disease Ontology:DOID:13608); cystic fibrosis (Disease Ontology:DOID:1485); asthma (Disease Ontology:DOID:2841); severe acute respiratory syndrome (Disease Ontology:DOID:2945); pulmonary tuberculosis (Disease Ontology:DOID:2957); IgA glomerulonephritis (Disease Ontology:DOID:2986); carotid artery disease (Disease Ontology:DOID:3407); rhinitis (Disease Ontology:DOID:4483); pneumonia (Disease Ontology:DOID:552); myocardial infarction (Disease Ontology:DOID:5844); periodontitis (Disease Ontology:DOID:824); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:12475); (R-MMU-140534); (R-MMU-166016); (R-MMU-166020); (R-MMU-166166); (R-MMU-2562578); (R-MMU-5686938); (R-MMU-6798695); (R-MMU-936964); (R-MMU-937041); (R-MMU-937072); (R-MMU-975163); (R-MMU-9824878)", "pathway_count": 13, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;15644310;15895089;16148141;1694207;19362712;21821728;24380872;2467257;2472171;37098757;8612135", "class_list": "", "function": "CD14 is not required for carbon tetrachloride-induced hepatic inflammation and fibrosis with or without lipopolysaccharide challenge., [RefSeq, PubMed]; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:16148141). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:15895089, PubMed:8612135). Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway (By similarity). Acts as an accessory receptor for M.tuberculosis lipoproteins LprA, LprG and LpqH, in conjunction with coreceptors TLR2 and TLR1. The lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen (PubMed:19362712). Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]; This gene encodes a protein that plays an important role in the innate immune response and is expressed in monocyte/macrophage cells. This gene product acts as a co-receptor that binds several microbial and fungal molecules, including lipopolysaccharides (LPS). This proteins LPS-binding activity is enhanced by the LPS binding protein (LBP) to allow binding to the TLR4-MD-2 co-receptor complex. The product of this gene is found in two forms, either as a soluble protein or attached to the cell surface by a glycosylphosphatidylinositol anchor. [provided by RefSeq, Jul 2014]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 3, "disease_count": 24, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001530 lipopolysaccharide binding;GO:0070891 lipoteichoic acid binding;GO:0001875 lipopolysaccharide immune receptor activity;GO:0140104 molecular carrier activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0009986 cell surface;GO:0045121 membrane raft;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0034612 response to tumor necrosis factor;GO:0045087 innate immune response;GO:0045471 response to ethanol;GO:0009617 response to bacterium", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P10810-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30280-1", "uniprot_id": [ { "id": "CCND2_MOUSE", "url": "https://www.uniprot.org/uniprot/P30280", "type": "external" } ], "mass": 32897.0, "length": 289, "protein_name": "G1/S-specific cyclin-D2", "gene_name": "Ccnd2", "organism": "Mouse", "refseq_name": "G1/S-specific cyclin-D2", "refseq_ac": [ { "id": "NP_033959", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033959", "type": "external" } ], "gene_names_uniprotkb": "Ccnd2; Cyl-2", "gene_names_refseq": "2600016F06Rik; Ccnd2; Vin-1; Vin1; cD2", "protein_names_uniprotkb": "G1/S-specific cyclin-D2", "protein_names_refseq": "G1/S-specific cyclin-D2", "tax_id": 10090, "disease": "colon adenoma (Disease Ontology:DOID:0050912); ductal carcinoma in situ (Disease Ontology:DOID:0060074); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); nephritis (Disease Ontology:DOID:10952); polycystic ovary syndrome (Disease Ontology:DOID:11612); renovascular hypertension (Disease Ontology:DOID:1591); breast cancer (Disease Ontology:DOID:1612); glaucoma (Disease Ontology:DOID:1686); impotence (Disease Ontology:DOID:1875); hepatitis B (Disease Ontology:DOID:2043); nephroblastoma (Disease Ontology:DOID:2154); colon cancer (Disease Ontology:DOID:219); transitional cell carcinoma (Disease Ontology:DOID:2671); granulosa cell tumor (Disease Ontology:DOID:2999); germinoma (Disease Ontology:DOID:3304); invasive lobular carcinoma (Disease Ontology:DOID:3457); liver cancer (Disease Ontology:DOID:3571); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); seminoma (Disease Ontology:DOID:4440); liver cirrhosis (Disease Ontology:DOID:5082); stomach carcinoma (Disease Ontology:DOID:5517); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (mmu:12444); (R-MMU-69231); (R-MMU-8934593); (R-MMU-9754119)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "1372445;17486076;1827757;19628581;21183079;21750661;27056896;30084848;33854232;33854235", "class_list": "", "function": "Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 28, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0043539 protein serine/threonine kinase activator activity;GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity;GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0008344 adult locomotory behavior;GO:0043066 negative regulation of apoptotic process;GO:0051301 cell division;GO:0000082 G1/S transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P30280-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43241-1", "uniprot_id": [ { "id": "CDX2_MOUSE", "url": "https://www.uniprot.org/uniprot/P43241", "type": "external" } ], "mass": 33476.0, "length": 311, "protein_name": "Homeobox protein CDX-2", "gene_name": "Cdx2", "organism": "Mouse", "refseq_name": "homeobox protein CDX-2", "refseq_ac": [ { "id": "NP_031699", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031699", "type": "external" } ], "gene_names_uniprotkb": "Cdx2; Cdx-2", "gene_names_refseq": "Cdx-2; Cdx2", "protein_names_uniprotkb": "Homeobox protein CDX-2; Caudal-type homeobox protein 2", "protein_names_refseq": "caudal type homeo box 2; caudal-type homeobox protein 2; homeobox protein CDX-2", "tax_id": 10090, "disease": "Barrett's esophagus (Disease Ontology:DOID:9206)", "pathway": " (mmu:12591)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11729123;16027724;1671571;23316940;7910823;7935448;9512360;9933478", "class_list": "", "function": "Transcription factor which regulates the transcription of multiple genes expressed in the intestinal epithelium (PubMed:16027724, PubMed:9933478). Binds to the promoter of the intestinal sucrase-isomaltase SI and activates SI transcription (PubMed:7935448). Binds to the DNA sequence 5'-ATAAAAACTTAT-3' in the promoter region of VDR and activates VDR transcription (PubMed:9933478). Binds to and activates transcription of LPH (By similarity). Activates transcription of CLDN2 and intestinal mucin MUC2 (PubMed:16027724). Binds to the 5'-AATTTTTTACAACACCT-3' DNA sequence in the promoter region of CA1 and activates CA1 transcription (PubMed:9512360). Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0003690 double-stranded DNA binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0017053 transcription repressor complex;GO:0032991 protein-containing complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P43241-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q09M05-4", "uniprot_id": [ { "id": "CBPC4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q09M05", "type": "external" } ], "mass": 126149.0, "length": 1122, "protein_name": "Cytosolic carboxypeptidase 4", "gene_name": "Agbl1", "organism": "Mouse", "refseq_name": "cytosolic carboxypeptidase 4", "refseq_ac": [ { "id": "NP_001186153", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186153", "type": "external" } ], "gene_names_uniprotkb": "Agbl1; Ccp4", "gene_names_refseq": "Agbl1; Ccp4; D430020F16; EG244071; Nna1-l1", "protein_names_uniprotkb": "Cytosolic carboxypeptidase 4; 3.4.17.-; 3.4.17.24; ATP/GTP-binding protein-like 1; Protein deglutamylase CCP4", "protein_names_refseq": "cytosolic carboxypeptidase 4; protein deglutamylase CCP4", "tax_id": 10090, "disease": "Fuchs' endothelial dystrophy (Disease Ontology:DOID:11555)", "pathway": " (mmu:244071)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17244818;21074048;25103237;34203471", "class_list": "", "function": "Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins (PubMed:21074048). Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of tubulin protein (PubMed:21074048). Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate (PubMed:21074048). Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of non-tubulin proteins such as MYLK (PubMed:21074048)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C768", "ec_number_list": [ { "id": "3.4.17.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.-", "type": "external" }, { "id": "3.4.17.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.24", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004181 metallocarboxypeptidase activity;GO:0015631 tubulin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0006508 proteolysis;GO:0035610 protein side chain deglutamylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q09M05-4", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q14AX6-1", "uniprot_id": [ { "id": "CDK12_MOUSE", "url": "https://www.uniprot.org/uniprot/Q14AX6", "type": "external" } ], "mass": 163681.0, "length": 1484, "protein_name": "Cyclin-dependent kinase 12", "gene_name": "Cdk12", "organism": "Mouse", "refseq_name": "cyclin-dependent kinase 12 isoform 1", "refseq_ac": [ { "id": "NP_001103096", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103096", "type": "external" } ], "gene_names_uniprotkb": "Cdk12; Crk7; Crkrs; Kiaa0904", "gene_names_refseq": "1810022J16Rik; Cdk12; Crk7; Crkrs; D11Ertd752e; Pksc", "protein_names_uniprotkb": "Cyclin-dependent kinase 12; 2.7.11.22; 2.7.11.23; CDC2-related protein kinase 7; Cdc2-related kinase, arginine/serine-rich; Cell division cycle 2-related protein kinase 7; Cell division protein kinase 12; CrkRS", "protein_names_refseq": "CDC2-related kinase 7; CDC2-related kinase, arginine/serine-rich; CDC2-related protein kinase 7; cell division cycle 2-related protein kinase 7; cell division protein kinase 12; cyclin-dependent kinase 12 isoform 1; protein kinase for splicing component", "tax_id": 10090, "disease": "stomach cancer (Disease Ontology:DOID:10534); gastric adenocarcinoma (Disease Ontology:DOID:3717); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:69131); (R-MMU-6796648)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "17242355;19131326;21183079;21606357;22012619;22517741;22645316;31219806;32782141;34428180;36852467;37100369;38481813;38736108;40021952;40885482;40997131", "class_list": "", "function": "Cyclin-dependent kinase 12 deficiency reprogrammes cellular metabolism to alleviate ferroptosis potential and promote the progression of castration-resistant prostate cancer., [RefSeq, PubMed]; Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors., [UniProtKB, PubMed]; Targeting CDK12 obviates the malignant phenotypes of colorectal cancer through the Wnt/beta-catenin signaling pathway., [RefSeq, PubMed]; Tubule-specific cyclin-dependent kinase 12 knockdown potentiates kidney injury through transcriptional elongation defects. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 8, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 8, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 8, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 38, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "A2A530;A2A531;B1AQH7;Q6ZQ27;Q8R457", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0019908 nuclear cyclin-dependent protein kinase holoenzyme complex;GO:0002944 cyclin K-CDK12 complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0008380 RNA splicing;GO:0006366 transcription by RNA polymerase II;GO:0043484 regulation of RNA splicing", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q14AX6-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3V3V9-1", "uniprot_id": [ { "id": "CARL2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3V3V9", "type": "external" } ], "mass": 141372.0, "length": 1296, "protein_name": "Capping protein, Arp2/3 and myosin-I linker protein 2", "gene_name": "Carmil2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Carmil2; Lrrc16c; Rltpr", "gene_names_refseq": "", "protein_names_uniprotkb": "Capping protein, Arp2/3 and myosin-I linker protein 2; Capping protein regulator and myosin 1 linker 2; F-actin-uncapping protein RLTPR; Leucine-rich repeat-containing protein 16C; RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein", "protein_names_refseq": "", "tax_id": 10090, "disease": "immunodeficiency 58 (Disease Ontology:DOID:0111984)", "pathway": "", "pathway_count": 0, "publication_count": 5, "publication_id_list": "21183079;24129315;27647348;32152506;34428180", "class_list": "", "function": "Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization. Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations. Involved as well in cell migration and invadopodia formation during wound healing (By similarity). Required for CD28-mediated stimulation of NF-kappa-B signaling, involved in naive T cells activation, maturation into T memory cells, and differentiation into T helper cells (PubMed:27647348). Required for CD28-mediated differentiation of T regulatory cells (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0015629 actin cytoskeleton;GO:0030027 lamellipodium", "go_biological_process": "GO:0016477 cell migration;GO:0030335 positive regulation of cell migration;GO:0050852 T cell receptor signaling pathway;GO:0045184 establishment of protein localization;GO:0048538 thymus development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3V3V9-1", "record_type": "protein", "filter_code": "0000000.0000110.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63918-1", "uniprot_id": [ { "id": "CAVN2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q63918", "type": "external" } ], "mass": 46764.0, "length": 418, "protein_name": "Caveolae-associated protein 2", "gene_name": "Cavin2", "organism": "Mouse", "refseq_name": "caveolae-associated protein 2", "refseq_ac": [ { "id": "NP_620080", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620080", "type": "external" } ], "gene_names_uniprotkb": "Cavin2; Sdpr; Sdr", "gene_names_refseq": "Cavin2; Sdpr", "protein_names_uniprotkb": "Caveolae-associated protein 2; Cavin-2; Phosphatidylserine-binding protein; Serum deprivation-response protein", "protein_names_refseq": "caveolae-associated protein 2; cavin-2; phosphatidylserine-binding protein; serum deprivation response; serum deprivation-response protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:20324)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "17242355;18332105;19131326;19546242;21183079;23652019;25428506;25588833;26495903;28011936;28912276;30084848;30779550;31219806;33725478;34428180;34896640;36210013;36288343;37507081;37872863;8241023", "class_list": "", "function": "Cavin-2 promotes fibroblast-to-myofibroblast trans-differentiation and aggravates cardiac fibrosis., [RefSeq, PubMed]; Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae (By similarity). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells (PubMed:23652019). May play a role in targeting PRKCA to caveolae (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; Requirement of Cavin-2 for the expression and stability of IRbeta in adequate adipocyte differentiation., [RefSeq, PubMed]; Results indicate that in addition to its function in caveolae biogenesis, Cavin-2 plays a critical role in endothelial cell maintenance and function by regulating eNOS activity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 22, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V1P6;Q78EC3;Q8CBT4", "ec_number_list": [], "go_molecular_function": "GO:0005080 protein kinase C binding;GO:0001786 phosphatidylserine binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0045121 membrane raft", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0097320 plasma membrane tubulation", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q63918-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BI79-1", "uniprot_id": [ { "id": "CCD40_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BI79", "type": "external" } ], "mass": 136772.0, "length": 1192, "protein_name": "Coiled-coil domain-containing protein 40", "gene_name": "Ccdc40", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 40 isoform 3", "refseq_ac": [ { "id": "NP_001395322", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001395322", "type": "external" } ], "gene_names_uniprotkb": "Ccdc40; Lnks", "gene_names_refseq": "B930008I02Rik; Ccdc40", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 40; Protein links", "protein_names_refseq": "coiled-coil domain-containing protein 40 isoform 3; coiled-coil domain-containing protein 40", "tax_id": 10090, "disease": "primary ciliary dyskinesia 15 (Disease Ontology:DOID:0110623); primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": " (mmu:207607)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.3389/fragi.2021.757801;21131972;21183079;21750661;28182636;34428180;35822049", "class_list": "", "function": "A model to explain how left isomerism arises in a proportion of Ccdc40lnks mutants is proposed. Publication Status: Online-Only, [RefSeq, PubMed]; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC39 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Not required for outer dynein arm complexes assembly. Required for axonemal recruitment of CCDC39., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AFL0;Q5U4C0;Q8BI59", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005929 cilium;GO:0031514 motile cilium;GO:0005930 axoneme", "go_biological_process": "GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0030317 flagellated sperm motility;GO:0030324 lung development;GO:0007368 determination of left/right symmetry;GO:0001947 heart looping", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BI79-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91VJ2-1", "uniprot_id": [ { "id": "CAVN3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91VJ2", "type": "external" } ], "mass": 27853.0, "length": 260, "protein_name": "Caveolae-associated protein 3", "gene_name": "Cavin3", "organism": "Mouse", "refseq_name": "caveolae-associated protein 3", "refseq_ac": [ { "id": "NP_082720", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082720", "type": "external" } ], "gene_names_uniprotkb": "Cavin3; Prkcdbp; Srbc", "gene_names_refseq": "3110015B12Rik; 6330514M23Rik; Cavin3; Prkcdbp; SRBC", "protein_names_uniprotkb": "Caveolae-associated protein 3; Cavin-3; Protein kinase C delta-binding protein; Serum deprivation response factor-related gene product that binds to C-kinase", "protein_names_refseq": "caveolae-associated protein 3; cavin-3; protein kinase C, delta binding protein; serum deprivation response factor-related gene product that binds to C-kinase", "tax_id": 10090, "disease": "", "pathway": " (mmu:109042)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "17242355;19546242;21183079;23079727;23652019;25588833;28285351;31219806;32679831;33649389;34428180;9054438", "class_list": "", "function": "Caveolae-Associated Protein 3 (Cavin-3) Influences Adipogenesis via TACE-Mediated Pref-1 Shedding. Publication Status: Online-Only, [RefSeq, PubMed]; Regulates the traffic and/or budding of caveolae (By similarity). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells (PubMed:23652019, PubMed:28285351). Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by promoting the rapid release of caveolae from the cell surface (PubMed:25588833). Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2 (PubMed:23079727)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]; The roles of cavins 2 and 3 in caveolar morphogenesis in vivo, are reported., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C064;Q9CRW1", "ec_number_list": [], "go_molecular_function": "GO:0005080 protein kinase C binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005901 caveola;GO:0032991 protein-containing complex", "go_biological_process": "GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0030866 cortical actin cytoskeleton organization;GO:0032922 circadian regulation of gene expression;GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:1901003 negative regulation of fermentation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q91VJ2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3V125-1", "uniprot_id": [ { "id": "CC110_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3V125", "type": "external" } ], "mass": 96356.0, "length": 848, "protein_name": "Coiled-coil domain-containing protein 110", "gene_name": "Ccdc110", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 110", "refseq_ac": [ { "id": "NP_001028418", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028418", "type": "external" } ], "gene_names_uniprotkb": "Ccdc110; Gm172", "gene_names_refseq": "Ccdc110; Gm172", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 110", "protein_names_refseq": "coiled-coil domain-containing protein 110", "tax_id": 10090, "disease": "", "pathway": " (mmu:212392)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21183079;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TTQ8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3V125-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19437-1", "uniprot_id": [ { "id": "CD20_MOUSE", "url": "https://www.uniprot.org/uniprot/P19437", "type": "external" } ], "mass": 31958.0, "length": 291, "protein_name": "B-lymphocyte antigen CD20", "gene_name": "Ms4a1", "organism": "Mouse", "refseq_name": "B-lymphocyte antigen CD20", "refseq_ac": [ { "id": "NP_031667", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031667", "type": "external" } ], "gene_names_uniprotkb": "Ms4a1; Cd20; Ly-44; Ms4a2", "gene_names_refseq": "Cd20; Ly-44; Ms4a1; Ms4a2", "protein_names_uniprotkb": "B-lymphocyte antigen CD20; B-cell differentiation antigen Ly-44; Lymphocyte antigen 44; Membrane-spanning 4-domains subfamily A member 1", "protein_names_refseq": "B-cell differentiation antigen Ly-44; B-lymphocyte antigen CD20; CD20 antigen; lymphocyte antigen 44; membrane-spanning 4-domains, subfamily A, member 2", "tax_id": 10090, "disease": "common variable immunodeficiency 5 (Disease Ontology:DOID:0081148); glomerulonephritis (Disease Ontology:DOID:2921)", "pathway": " (mmu:12482)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "14688067;20038800;21183079;2461992;25428506;26495903;26740625;28533311;30084848;32152506;34428180;38637611;8450218", "class_list": "", "function": "B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes. Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR., [UniProtKB, UniProtKB]; CD20/MS4A1 is a mammalian olfactory receptor expressed in a subset of olfactory sensory neurons that mediates innate avoidance of predators. Publication Status: Online-Only, [RefSeq, PubMed]; Our findings indicate that anti-CD20-IFNalpha eradicates B-cell lymphoma by employing tumor cells as antigen-presenting cells to reactivate tumor-infiltrating CD8(+) T cells and synergizing with anti-PD-L1 treatment, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005154 epidermal growth factor receptor binding;GO:0019865 immunoglobulin binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0044853 plasma membrane raft;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0051262 protein tetramerization;GO:0042113 B cell activation;GO:0009617 response to bacterium;GO:0050853 B cell receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P19437-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24161-1", "uniprot_id": [ { "id": "CD3Z_MOUSE", "url": "https://www.uniprot.org/uniprot/P24161", "type": "external" } ], "mass": 18637.0, "length": 164, "protein_name": "T-cell surface glycoprotein CD3 zeta chain", "gene_name": "Cd247", "organism": "Mouse", "refseq_name": "CD247 antigen isoform zeta precursor", "refseq_ac": [ { "id": "NP_001106862", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106862", "type": "external" } ], "gene_names_uniprotkb": "Cd247; Cd3z; Tcrz", "gene_names_refseq": "4930549J05Rik; A430104F18Rik; Cd247; Cd3-eta; Cd3-zeta; Cd3h; Cd3zeta; Cd3z; Cd3; T3z; Tcrk; Tcrz", "protein_names_uniprotkb": "T-cell surface glycoprotein CD3 zeta chain; T-cell receptor T3 zeta chain", "protein_names_refseq": "CD247 antigen isoform zeta precursor; CD3 antigen, zeta polypeptide; CD3-zeta/eta; T-cell receptor T3 eta chain; T-cell surface glycoprotein CD3 zeta chain", "tax_id": 10090, "disease": "immunodeficiency 25 (Disease Ontology:DOID:0111942)", "pathway": " (mmu:12503); (R-MMU-198933); (R-MMU-202424); (R-MMU-202427); (R-MMU-202430); (R-MMU-202433); (R-MMU-389948)", "pathway_count": 7, "publication_count": 13, "publication_id_list": "10662792;11891219;1828894;20188655;2139725;2150596;21750661;2787796;3278377;37945821;38117282;8223495;9575182", "class_list": "", "function": "Alternatively Spliced Variants of Murine CD247 Influence T Cell Development and Activation, Revealing the Importance of the CD3zeta C-Terminal Region., [RefSeq, PubMed]; CD3zeta ITAMs enable ligand discrimination and antagonism by inhibiting TCR signaling in response to low-affinity peptides. Erratum:[Nat Immunol. 2024 Mar;25(3):579. doi: 10.1038/s41590-023-01725-5. PMID: 38057618], [RefSeq, PubMed]; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD247/CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. CD247/CD3Z ITAMs phosphorylation creates multiple docking sites for the protein kinase ZAP70 leading to ZAP70 phosphorylation and its conversion into a catalytically active enzyme. Plays an important role in intrathymic T-cell differentiation. Additionally, participates in the activity-dependent synapse formation of retinal ganglion cells (RGCs) in both the retina and dorsal lateral geniculate nucleus (dLGN)., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P29020;Q9D3G3", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0032395 MHC class II receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0042101 T cell receptor complex;GO:0042105 alpha-beta T cell receptor complex", "go_biological_process": "GO:0038094 Fc-gamma receptor signaling pathway;GO:0007166 cell surface receptor signaling pathway;GO:0051259 protein complex oligomerization;GO:2000010 positive regulation of protein localization to cell surface;GO:0050852 T cell receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P24161-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D5Y1-1", "uniprot_id": [ { "id": "CCD39_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D5Y1", "type": "external" } ], "mass": 110072.0, "length": 937, "protein_name": "Coiled-coil domain-containing protein 39", "gene_name": "Ccdc39", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 39", "refseq_ac": [ { "id": "NP_080498", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080498", "type": "external" } ], "gene_names_uniprotkb": "Ccdc39; D3Ertd789e", "gene_names_refseq": "4921507O14Rik; Ccdc39; D3Ertd789e; b2b1304Clo; b2b1735Clo; b2b2025.1Clo; prh", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 39", "protein_names_refseq": "coiled-coil domain-containing protein 39", "tax_id": 10090, "disease": "Kartagener syndrome (Disease Ontology:DOID:0050144); visceral heterotaxy (Disease Ontology:DOID:0050545); primary ciliary dyskinesia 14 (Disease Ontology:DOID:0110598); hydrocephalus (Disease Ontology:DOID:10908)", "pathway": " (mmu:51938)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17971504;21131972;21183079;29317443;37296418", "class_list": "", "function": "Ccdc39 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]; Data provide the first evidence for involvement of Ccdc39 in hydrocephalus and suggest that the proper development of medial wall ependymal cilia is crucial for normal mouse brain development. Publication Status: Online-Only, [RefSeq, PubMed]; Early postnatal microglial ablation in the Ccdc39 mouse model reveals adverse effects on brain development and in neonatal hydrocephalus. Publication Status: Online-Only, [RefSeq, PubMed]; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Not required for outer dynein arm complexes assembly., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RSM0;Q8CDG6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005829 cytosol;GO:0005929 cilium;GO:0005930 axoneme;GO:0097729 9+2 motile cilium", "go_biological_process": "GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0007399 nervous system development;GO:0007507 heart development;GO:0022010 central nervous system myelination;GO:0021987 cerebral cortex development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9D5Y1-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1Q5-1", "uniprot_id": [ { "id": "CLIC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z1Q5", "type": "external" } ], "mass": 27013.0, "length": 241, "protein_name": "Chloride intracellular channel protein 1", "gene_name": "Clic1", "organism": "Mouse", "refseq_name": "chloride intracellular channel protein 1", "refseq_ac": [ { "id": "NP_254279", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_254279", "type": "external" } ], "gene_names_uniprotkb": "Clic1", "gene_names_refseq": "Clcp; Clic1; G6", "protein_names_uniprotkb": "Chloride intracellular channel protein 1; 1.8.-.-; 1.8.5.1; Glutaredoxin-like oxidoreductase CLIC1; Glutathione-dependent dehydroascorbate reductase CLIC1; NCC27; Nuclear chloride ion channel 27", "protein_names_refseq": "NCC27; chloride intracellular channel protein 1; glutaredoxin-like oxidoreductase CLIC1; glutathione-dependent dehydroascorbate reductase CLIC1; nuclear chloride ion channel 27", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:114584)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;14656967;17947660;19478202;23806337;25605945;29187734;34428180;35984892;37507081;37828378;39627609", "class_list": "", "function": "In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Reduces selenite and dehydroascorbate and may act as an antioxidant during oxidative stress response (By similarity). Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions. Involved in regulation of the cell cycle (By similarity)., [UniProtKB, UniProtKB]; Ischemia augmented CLIC1 and CLIC4 expression similarly in wild-type mice. However, CLIC1 increased 3-fold more in Clic4(-/-) mice, suggesting compensation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.20.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.20.4.2", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005254 chloride channel activity;GO:0045174 glutathione dehydrogenase (ascorbate) activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0051881 regulation of mitochondrial membrane potential;GO:0006821 chloride transport;GO:0045669 positive regulation of osteoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9Z1Q5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BJQ9-1", "uniprot_id": [ { "id": "CGAT1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BJQ9", "type": "external" } ], "mass": 60917.0, "length": 530, "protein_name": "Chondroitin sulfate N-acetylgalactosaminyltransferase 1", "gene_name": "Csgalnact1", "organism": "Mouse", "refseq_name": "chondroitin sulfate N-acetylgalactosaminyltransferase 1", "refseq_ac": [ { "id": "NP_001239552", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239552", "type": "external" } ], "gene_names_uniprotkb": "Csgalnact1; Chgn; Galnact1", "gene_names_refseq": "4732435N03Rik; CSGalNAcT-1; Csgalnact1", "protein_names_uniprotkb": "Chondroitin sulfate N-acetylgalactosaminyltransferase 1; 2.4.1.174; Beta4GalNAcT-1; Chondroitin beta-1,4-N-acetylgalactosaminyltransferase 1; CsGalNAcT-1", "protein_names_refseq": "beta1,4 N-acetylgalactosaminyltransferase; beta4GalNAcT-1; chondroitin beta-1,4-N-acetylgalactosaminyltransferase 1; chondroitin sulfate N-acetylgalactosaminyltransferase 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:234356); (R-MMU-2022870)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;17145758;20812917;21148564;21750661;30459452;32839819;34428180", "class_list": "glycogene;glycosyltransferase", "function": "CSGalNAcT1 plays important roles in connective tissue organization and following intramembranous ossification of the craniofacial skeleton. Publication Status: Online-Only, [RefSeq, PubMed]; Chondroitin sulfate N-acetylgalactosyltransferase-1 knockout shows milder phenotype in experimental autoimmune encephalomyelitis than in wild type., [RefSeq, PubMed]; Results suggest that CSGalNAcT1 is required for normal CS production in developing cartilage., [RefSeq, PubMed]; Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Important role in chondroitin chain biosynthesis in cartilage formation, and subsequent endochondral ossification (PubMed:17145758, PubMed:21148564). Moreover, is involved in the metabolism of aggrecan (PubMed:21148564)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 25, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UNQ5;Q3UZX6;Q5FWX8;Q8BWV9;Q8BZU7;Q8C195;Q8R0M6", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.174", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.174", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008376 acetylgalactosaminyltransferase activity;GO:0015020 glucuronosyltransferase activity;GO:0008955 peptidoglycan glycosyltransferase activity;GO:0047237 glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0030198 extracellular matrix organization;GO:0051216 cartilage development;GO:0050650 chondroitin sulfate proteoglycan biosynthetic process;GO:0019276 UDP-N-acetylgalactosamine metabolic process;GO:0001958 endochondral ossification", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8BJQ9-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000010000.101.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QXT0-1", "uniprot_id": [ { "id": "CNPY2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QXT0", "type": "external" } ], "mass": 20767.0, "length": 182, "protein_name": "Protein canopy homolog 2", "gene_name": "Cnpy2", "organism": "Mouse", "refseq_name": "protein canopy homolog 2 precursor", "refseq_ac": [ { "id": "NP_064337", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064337", "type": "external" } ], "gene_names_uniprotkb": "Cnpy2; Msap; Tmem4; Zsig9", "gene_names_refseq": "5330432A10Rik; Cnpy2; D10Bwg1546e; Tmem4; Zsig9", "protein_names_uniprotkb": "Protein canopy homolog 2; MIR-interacting saposin-like protein; Putative secreted protein ZSIG9; Transmembrane protein 4", "protein_names_refseq": "MIR-interacting saposin-like protein; canopy 2 homolog; protein canopy homolog 2 precursor; protein canopy homolog 2; putative secreted protein ZSIG9; transmembrane protein 4", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (mmu:56530)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "17242355;21750661;25393402;28869608;28981072;34986508;37103758;37828378", "class_list": "", "function": "Canopy Homolog 2 contributes to liver oncogenesis by promoting unfolded protein response-dependent destabilization of tumor protein P53., [RefSeq, PubMed]; Free CNPY2 then engages protein kinase R-like endoplasmic reticulum kinase (PERK) to induce expression of the transcription factor C/EBP homologous protein (CHOP), thereby initiating the unfolded protein response., [RefSeq, PubMed]; Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation (By similarity)., [UniProtKB]; Sustained PERK activation can amplify PERK signaling by further enhancing CNPY2 expression via direct transactivation through CHOP., [RefSeq, PubMed]; The data demonstrate CNPY2 is widely distributed in tissues and suggest the protein has biological functions that have yet to be identified. Publication Status: Online-Only, [RefSeq, PubMed]; The role of CNPY2 in endothelial injury and inflammation during the progress of atherosclerosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UBH8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0010629 negative regulation of gene expression;GO:0010988 regulation of low-density lipoprotein particle clearance", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9QXT0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q2Z1-1", "uniprot_id": [ { "id": "CECR2_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q2Z1", "type": "external" } ], "mass": 161530.0, "length": 1453, "protein_name": "Chromatin remodeling regulator CECR2", "gene_name": "Cecr2", "organism": "Mouse", "refseq_name": "chromatin remodeling regulator CECR2 isoform 1", "refseq_ac": [ { "id": "NP_001121623", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121623", "type": "external" } ], "gene_names_uniprotkb": "Cecr2; Kiaa1740", "gene_names_refseq": "2610101O16Rik; 2810409N01Rik; Cecr2; Gtl4", "protein_names_uniprotkb": "Chromatin remodeling regulator CECR2; Cat eye syndrome critical region protein 2 homolog", "protein_names_refseq": "cat eye syndrome chromosome region, candidate 2 homolog; cat eye syndrome critical region protein 2 homolog; chromatin remodeling regulator CECR2 isoform 1; chromatin remodeling regulator CECR2; gene trap locus 4", "tax_id": 10090, "disease": "anencephaly (Disease Ontology:DOID:0060668)", "pathway": " (mmu:330409)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15640247;20589882;21183079;21246654;21750661;22154806;24129315;34197713;34904570;35108062", "class_list": "", "function": "A novel Cecr2 null allele (Cecr2(tm1.1Hemc)) had a stronger penetrance of exencephaly than Cecr2(Gt45Bic) in both BALB/c and FVB/N strains, in addition to midline facial clefts and forebrain encephalocele in the FVB/N strain., [RefSeq, PubMed]; CECR2 drives breast cancer metastasis by promoting NF-kappaB signaling and macrophage-mediated immune suppression., [RefSeq, PubMed]; CECR2, a protein involved in neurulation, forms a novel chromatin remodeling complex with SNF2L during neurulation, [RefSeq, PubMed]; Chromatin remodeling factor CECR2 forms tissue-specific complexes with CCAR2 and LUZP1., [RefSeq, PubMed]; Regulatory subunit of the ATP-dependent CERF-1 and CERF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (By similarity). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (By similarity). The CERF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the CERF-5 ISWI chromatin remodeling complex (By similarity). Plays a role in various processes during development: required during embryogenesis for neural tube closure and inner ear development (PubMed:15640247, PubMed:20589882, PubMed:21246654). In adults, required for spermatogenesis, via the formation of ISWI-type chromatin complexes (PubMed:22154806). In histone-modifying complexes, CECR2 recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated (By similarity). May also be involved through its interaction with LRPPRC in the integration of cytoskeletal network with vesicular trafficking, nucleocytosolic shuttling, transcription, chromosome remodeling and cytokinesis (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Subfertility in young male mice mutant for chromatin remodeller CECR2. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9QA25;F6VR46;F7B218;Q6PAQ2;Q6ZPI9", "ec_number_list": [], "go_molecular_function": "GO:0140658 ATP-dependent chromatin remodeler activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000791 euchromatin;GO:0090537 CERF complex;GO:0031010 ISWI-type complex", "go_biological_process": "GO:0001842 neural fold formation;GO:0006338 chromatin remodeling;GO:0007338 single fertilization;GO:0001843 neural tube closure;GO:0021915 neural tube development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "E9Q2Z1-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BNX1-1", "uniprot_id": [ { "id": "CLC4G_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BNX1", "type": "external" } ], "mass": 33327.0, "length": 294, "protein_name": "C-type lectin domain family 4 member G", "gene_name": "Clec4g", "organism": "Mouse", "refseq_name": "C-type lectin domain family 4 member G", "refseq_ac": [ { "id": "NP_083741", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083741", "type": "external" } ], "gene_names_uniprotkb": "Clec4g", "gene_names_refseq": "4930572L20Rik; Clec4g; Gm9814", "protein_names_uniprotkb": "C-type lectin domain family 4 member G", "protein_names_refseq": "C-type lectin domain family 4 member G", "tax_id": 10090, "disease": "", "pathway": " (mmu:75863); (R-MMU-198933)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "19632227;21257728;21750661;22884358;25957769;27184407", "class_list": "glycogene", "function": "Binds mannose, N-acetylglucosamine (GlcNAc) and fucose, but not galactose, in a Ca(2+)-dependent manner., [UniProtKB, UniProtKB]; Data show that C-type lectin-like domain family 4, member g (Clec4g) suppresses beta-Site amyloid precursor protein cleaving enzyme-1 (BACE1)-mediated amyloid-beta (Abeta) peptides generation., [RefSeq, PubMed]; LSECtin-mediated signaling up-regulates the threshold of CD4(+) T cell activation via tuning the expression of Cbl-b., [RefSeq, PubMed]; Liver sinusoidal endothelial cell lectin, LSECtin, negatively regulates hepatic T-cell immune response., [RefSeq, PubMed]; The studies provide a basis for using mouse LSECtin, and knockout mice lacking this receptor, to model the biological properties of the human receptor., [RefSeq, PubMed]; This study shows that C-type lectin LSECtin, a member of the DC-SIGN family, is a novel liver regulator for natural killer cells (NK cells). LSECtin could bind to NK cells in a carbohydrate-dependent manner and could regulate the number of hepatic NK cells., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 20, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q5I0T7;Q8R188", "ec_number_list": [], "go_molecular_function": "GO:0030247 polysaccharide binding;GO:0030246 carbohydrate binding;GO:0001618 virus receptor activity;GO:0070061 fructose binding;GO:0005537 D-mannose binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0002710 negative regulation of T cell mediated immunity;GO:0006955 immune response;GO:0042130 negative regulation of T cell proliferation;GO:0046718 symbiont entry into host cell;GO:1903902 positive regulation of viral life cycle", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BNX1-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47936-1", "uniprot_id": [ { "id": "CNR2_MOUSE", "url": "https://www.uniprot.org/uniprot/P47936", "type": "external" } ], "mass": 38213.0, "length": 347, "protein_name": "Cannabinoid receptor 2", "gene_name": "Cnr2", "organism": "Mouse", "refseq_name": "cannabinoid receptor 2", "refseq_ac": [ { "id": "NP_001292207", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001292207", "type": "external" } ], "gene_names_uniprotkb": "Cnr2", "gene_names_refseq": "CB-2; CB2-R; CB2; Cnr2", "protein_names_uniprotkb": "Cannabinoid receptor 2; CB-2; CB2; mCB2", "protein_names_refseq": "cannabinoid receptor 2 (macrophage); cannabinoid receptor 2 (spleen); cannabinoid receptor 2", "tax_id": 10090, "disease": "sciatic neuropathy (Disease Ontology:DOID:11446); Huntington's disease (Disease Ontology:DOID:12858); alcohol use disorder (Disease Ontology:DOID:1574); anxiety disorder (Disease Ontology:DOID:2030); pancreatitis (Disease Ontology:DOID:4989); cocaine abuse (Disease Ontology:DOID:809); arthritis (Disease Ontology:DOID:848); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (mmu:12802); (R-MMU-373076); (R-MMU-418594)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10822068;11929767;12511587;16407142;16563625;16924491;17401376;18286196;19144319;19757078;21183079;26495903;26740625;8679694;9261404", "class_list": "", "function": "Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Resting splenic B cells in mice use multiple transcript start sites and express at least three CB2 transcript variants., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q544H5", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004949 cannabinoid receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0031234 extrinsic component of cytoplasmic side of plasma membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0032496 response to lipopolysaccharide;GO:0032229 negative regulation of synaptic transmission, GABAergic", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P47936-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKY0-1", "uniprot_id": [ { "id": "CNOT9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JKY0", "type": "external" } ], "mass": 33601.0, "length": 299, "protein_name": "CCR4-NOT transcription complex subunit 9", "gene_name": "Cnot9", "organism": "Mouse", "refseq_name": "CCR4-NOT transcription complex subunit 9", "refseq_ac": [ { "id": "NP_067358", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067358", "type": "external" } ], "gene_names_uniprotkb": "Cnot9; Rcd1; Rqcd1", "gene_names_refseq": "2610007F23Rik; Cnot9; Fl10; Rqcd1", "protein_names_uniprotkb": "CCR4-NOT transcription complex subunit 9; Cell differentiation protein RQCD1 homolog; EPO-induced protein FL10; Rcd-1", "protein_names_refseq": "CCR4-NOT transcription complex subunit 9; EPO-induced protein FL10; RCD1 required for cell differentiation 1 homolog; cell differentiation protein RCD1 homolog; cell differentiation protein RQCD1 homolog; rcd-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:58184); (R-MMU-429947); (R-MMU-6804115)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10880228;12356739;15209511;18250455;20133598;25428506;25605945;30084848;33649389;34428180;35820727;37828378", "class_list": "", "function": "Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation. Required for retinoic acid-induced differentiation of F9 teratocarcinoma cells. Does not bind DNA by itself. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors. May play a role in cell differentiation., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0019904 protein domain specific binding;GO:0042803 protein homodimerization activity;GO:0019900 kinase binding;GO:0005154 epidermal growth factor receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0000932 P-body;GO:0032991 protein-containing complex;GO:0030014 CCR4-NOT complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0033138 positive regulation of peptidyl-serine phosphorylation;GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway;GO:0017148 negative regulation of translation;GO:0006402 mRNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9JKY0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62897-1", "uniprot_id": [ { "id": "CYC_MOUSE", "url": "https://www.uniprot.org/uniprot/P62897", "type": "external" } ], "mass": 11605.0, "length": 105, "protein_name": "Cytochrome c, somatic", "gene_name": "Cycs", "organism": "Mouse", "refseq_name": "cytochrome c, somatic", "refseq_ac": [ { "id": "NP_031834", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031834", "type": "external" } ], "gene_names_uniprotkb": "Cycs", "gene_names_refseq": "Cycs", "protein_names_uniprotkb": "Cytochrome c, somatic", "protein_names_refseq": "cytochrome c, somatic", "tax_id": 10090, "disease": "Huntington's disease (Disease Ontology:DOID:12858); thrombocytopenia (Disease Ontology:DOID:1588); pancreatic cancer (Disease Ontology:DOID:1793); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hyperglycemia (Disease Ontology:DOID:4195); cholangiocarcinoma (Disease Ontology:DOID:4947)", "pathway": " (mmu:13063); (R-MMU-111457); (R-MMU-111458); (R-MMU-111459); (R-MMU-111461); (R-MMU-2151201); (R-MMU-3299685); (R-MMU-5620971); (R-MMU-5628897); (R-MMU-611105); (R-MMU-9627069); (R-MMU-9707564)", "pathway_count": 12, "publication_count": 14, "publication_id_list": "10428801;12062423;191069;23576753;23806337;240690;2987801;34428180;36288343;37453647;37507081;38472487;38937450;39927985", "class_list": "", "function": "Altered conformational dynamics contribute to species-specific effects of cytochrome c mutations on caspase activation., [RefSeq, PubMed]; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain., [UniProtKB, PubMed]; MicroRNA miR-20a-5p targets CYCS to inhibit apoptosis in hepatocellular carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P00009;Q8C2S2", "ec_number_list": [], "go_molecular_function": "GO:0009055 electron transfer activity;GO:0019899 enzyme binding;GO:0046872 metal ion binding;GO:0020037 heme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space;GO:0005829 cytosol;GO:0043209 myelin sheath", "go_biological_process": "GO:0006915 apoptotic process;GO:0097193 intrinsic apoptotic signaling pathway;GO:0006123 mitochondrial electron transport, cytochrome c to oxygen;GO:0042743 hydrogen peroxide metabolic process;GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P62897-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "H3BL92-1", "uniprot_id": [ { "id": "H3BL92_MOUSE", "url": "https://www.uniprot.org/uniprot/H3BL92", "type": "external" } ], "mass": 91806.0, "length": 797, "protein_name": "Ecotropic viral integration site 5 like", "gene_name": "Evi5l", "organism": "Mouse", "refseq_name": "EVI5-like protein isoform 5", "refseq_ac": [ { "id": "NP_001355723", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001355723", "type": "external" } ], "gene_names_uniprotkb": "Evi5l", "gene_names_refseq": "1700084G18Rik; 2310039H16Rik; 3110007G05Rik; B130050I23Rik; Evi5l", "protein_names_uniprotkb": "Ecotropic viral integration site 5 like", "protein_names_refseq": "EVI5-like protein isoform 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:213027)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;21750661;27956704", "class_list": "", "function": "Tgifs regulate ciliogenesis and suggests that Evi5l mediates at least part of this effect. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9606, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0031267 small GTPase binding", "go_cellular_component": "", "go_biological_process": "GO:1902018 negative regulation of cilium assembly;GO:0043547 positive regulation of GTPase activity", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "H3BL92-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "K7N734-1", "uniprot_id": [ { "id": "K7N734_MOUSE", "url": "https://www.uniprot.org/uniprot/K7N734", "type": "external" } ], "mass": 24460.0, "length": 205, "protein_name": "Predicted gene 8108", "gene_name": "Gm8108", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gm8108", "gene_names_refseq": "", "protein_names_uniprotkb": "Predicted gene 8108", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:623078)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "K7N734-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80TZ3-1", "uniprot_id": [ { "id": "AUXI_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80TZ3", "type": "external" } ], "mass": 102299.0, "length": 938, "protein_name": "Auxilin", "gene_name": "Dnajc6", "organism": "Mouse", "refseq_name": "auxilin isoform a", "refseq_ac": [ { "id": "NP_001158055", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158055", "type": "external" } ], "gene_names_uniprotkb": "Dnajc6; Kiaa0473", "gene_names_refseq": "2810027M23Rik; Dnajc6; mKIAA0473", "protein_names_uniprotkb": "Auxilin; 3.1.3.-; DnaJ homolog subfamily C member 6", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily B, member 6; DnaJ (Hsp40) homolog, subfamily C, member 6; auxilin isoform a; dnaJ homolog subfamily C member 6; putative tyrosine-protein phosphatase auxilin", "tax_id": 10090, "disease": "Parkinson's disease 19A (Disease Ontology:DOID:0060891); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:72685); (R-MMU-432720); (R-MMU-432722); (R-MMU-8856828)", "pathway_count": 4, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;10.3389/fragi.2021.757801;20160091;21183079;21750661;22517741;22645316;25605945;30084848;30779550;32848054;33300544;34428180;35822049;37331165;40021952;40885482", "class_list": "", "function": "Gene regulation of RMR-related DNAJC6 on adipogenesis and mitochondria function in 3T3-L1 preadipocytes., [RefSeq, PubMed]; May act as a protein phosphatase and/or a lipid phosphatase. Co-chaperone that recruits HSPA8/HSC70 to clathrin-coated vesicles (CCVs) and promotes the ATP-dependent dissociation of clathrin from CCVs and participates in clathrin-mediated endocytosis of synaptic vesicles and their recycling and also in intracellular trafficking (PubMed:20160091). Firstly, binds tightly to the clathrin cages, at a ratio of one DNAJC6 per clathrin triskelion. The HSPA8:ATP complex then binds to the clathrin-auxilin cage, initially at a ratio of one HSPA8 per triskelion leading to ATP hydrolysis stimulation and causing a conformational change in the HSPA8. This cycle is repeated three times to drive to a complex containing the clathrin-auxilin cage associated to three HSPA8:ADP complex. The ATP hydrolysis of the third HSPA8:ATP complex leads to a concerted dismantling of the cage into component triskelia. Then, dissociates from the released triskelia and be recycled to initiate another cycle of HSPA8's recruitment. Also acts during the early steps of clathrin-coated vesicle (CCV) formation through its interaction with the GTP bound form of DNM1 (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "B1B0B9;Q6P2K9;Q8C7L9", "ec_number_list": [ { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.4.17.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.22", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.1.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.22.1", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "1.8.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" } ], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0031072 heat shock protein binding;GO:0030276 clathrin binding;GO:0004721 phosphoprotein phosphatase activity;GO:0032050 clathrin heavy chain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0014069 postsynaptic density;GO:0045202 synapse;GO:0030136 clathrin-coated vesicle;GO:0031982 vesicle", "go_biological_process": "GO:2000369 regulation of clathrin-dependent endocytosis;GO:0072583 clathrin-dependent endocytosis;GO:0046907 intracellular transport;GO:0036465 synaptic vesicle recycling;GO:0072318 clathrin coat disassembly", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q80TZ3-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0B4J1J7-1", "uniprot_id": [ { "id": "A0A0B4J1J7_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A0B4J1J7", "type": "external" } ], "mass": 10650.0, "length": 98, "protein_name": "Immunoglobulin heavy variable 1-82", "gene_name": "Ighv1-82", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ighv1-82", "gene_names_refseq": "", "protein_names_uniprotkb": "Immunoglobulin heavy variable 1-82", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-173623); (R-MMU-198933); (R-MMU-202733); (R-MMU-2029481); (R-MMU-2029482); (R-MMU-2029485); (R-MMU-2168880); (R-MMU-2454202); (R-MMU-2730905); (R-MMU-2871796); (R-MMU-2871809); (R-MMU-2871837); (R-MMU-5690714); (R-MMU-977606); (R-MMU-983695)", "pathway_count": 15, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0016064 immunoglobulin mediated immune response;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0B4J1J7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2BFG8-1", "uniprot_id": [ { "id": "A2BFG8_MOUSE", "url": "https://www.uniprot.org/uniprot/A2BFG8", "type": "external" } ], "mass": 54111.0, "length": 470, "protein_name": "Zinc finger protein 971", "gene_name": "Zfp1003; Zfp971", "organism": "Mouse", "refseq_name": "ethanol induced 1 isoform 1", "refseq_ac": [ { "id": "NP_001170870", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001170870", "type": "external" } ], "gene_names_uniprotkb": "Zfp1003; Zfp971", "gene_names_refseq": "Etohi1; Zfp971", "protein_names_uniprotkb": "Zinc finger protein 971", "protein_names_refseq": "KRAB box and zinc finger, C2H2 type domain containing protein; ethanol induced 1 isoform 1; ethanol induced 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:626848); (R-MMU-212436); (R-MMU-9843940)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2BFG8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3YVV3-1", "uniprot_id": [ { "id": "D3YVV3_MOUSE", "url": "https://www.uniprot.org/uniprot/D3YVV3", "type": "external" } ], "mass": 33176.0, "length": 309, "protein_name": "Ankyrin repeat domain 29", "gene_name": "Ankrd29", "organism": "Mouse", "refseq_name": "ankyrin repeat domain-containing protein 29 isoform 1", "refseq_ac": [ { "id": "NP_001177300", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001177300", "type": "external" } ], "gene_names_uniprotkb": "Ankrd29", "gene_names_refseq": "Ankrd29; G630054C21Rik; G630054C21; Gm95", "protein_names_uniprotkb": "Ankyrin repeat domain 29", "protein_names_refseq": "ankyrin repeat domain-containing protein 29 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:225187)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3YVV3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "L7N276-1", "uniprot_id": [ { "id": "L7N276_MOUSE", "url": "https://www.uniprot.org/uniprot/L7N276", "type": "external" } ], "mass": 24276.0, "length": 205, "protein_name": "Predicted gene 9602", "gene_name": "Gm9602", "organism": "Mouse", "refseq_name": "uncharacterized protein Gm9602", "refseq_ac": [ { "id": "XP_006518257", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006518257", "type": "external" } ], "gene_names_uniprotkb": "Gm9602", "gene_names_refseq": "Gm9602", "protein_names_uniprotkb": "Predicted gene 9602", "protein_names_refseq": "uncharacterized protein Gm9602", "tax_id": 10090, "disease": "", "pathway": " (mmu:673676)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "L7N276-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6UWZ4-1", "uniprot_id": [ { "id": "F6UWZ4_MOUSE", "url": "https://www.uniprot.org/uniprot/F6UWZ4", "type": "external" } ], "mass": 49153.0, "length": 438, "protein_name": "ER membrane associated RNA degradation like 1", "gene_name": "Ermardl1", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC100041621", "refseq_ac": [ { "id": "NP_001116844", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116844", "type": "external" } ], "gene_names_uniprotkb": "Ermardl1; Gm3435", "gene_names_refseq": "100041621; Ermardl1; Gm3435", "protein_names_uniprotkb": "ER membrane associated RNA degradation like 1", "protein_names_refseq": "uncharacterized protein LOC100041621", "tax_id": 10090, "disease": "periventricular nodular heterotopia (Disease Ontology:DOID:0050454)", "pathway": " (mmu:100041621)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F6UWZ4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3UXT0-1", "uniprot_id": [ { "id": "G3UXT0_MOUSE", "url": "https://www.uniprot.org/uniprot/G3UXT0", "type": "external" } ], "mass": 57768.0, "length": 502, "protein_name": "unspecific monooxygenase", "gene_name": "Cyp2j12", "organism": "Mouse", "refseq_name": "cytochrome P450, family 2, subfamily j, polypeptide 12, pseudogene isoform 1", "refseq_ac": [ { "id": "NP_001093652", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093652", "type": "external" } ], "gene_names_uniprotkb": "Cyp2j12", "gene_names_refseq": "Cyp2j12-ps; Cyp2j12", "protein_names_uniprotkb": "unspecific monooxygenase; 1.14.14.1", "protein_names_refseq": "cytochrome P450, family 2, subfamily j, polypeptide 12, pseudogene isoform 1; cytochrome P450, family 2, subfamily j, polypeptide 12, pseudogene", "tax_id": 10090, "disease": "renal fibrosis (Disease Ontology:DOID:0050855); pre-eclampsia (Disease Ontology:DOID:10591); renal hypertension (Disease Ontology:DOID:1073); hypertension (Disease Ontology:DOID:10763); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (mmu:242546)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" }, { "id": "1.14.14.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.-", "type": "external" }, { "id": "4.2.1.152", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.152", "type": "external" }, { "id": "1.14.13.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.n7", "type": "external" }, { "id": "5.3.99.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.5", "type": "external" } ], "go_molecular_function": "GO:0008404 arachidonate 14,15-epoxygenase activity;GO:0008405 arachidonate 11,12-epoxygenase activity;GO:0071614 linoleic acid epoxygenase activity;GO:0005506 iron ion binding;GO:0020037 heme binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006690 icosanoid metabolic process;GO:0043651 linoleic acid metabolic process;GO:0006805 xenobiotic metabolic process;GO:0019373 epoxygenase P450 pathway;GO:0006082 organic acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G3UXT0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5Y4Y6-1", "uniprot_id": [ { "id": "GSDA3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5Y4Y6", "type": "external" } ], "mass": 52020.0, "length": 464, "protein_name": "Gasdermin-A3", "gene_name": "Gsdma3", "organism": "Mouse", "refseq_name": "gasdermin-A3", "refseq_ac": [ { "id": "NP_001007462", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007462", "type": "external" } ], "gene_names_uniprotkb": "Gsdma3; Gsdm3", "gene_names_refseq": "Bsk; Dfl; Fgn; Gsdm1l; Gsdm3; GsdmA-3; Gsdma3; Rco2; Rim3", "protein_names_uniprotkb": "Gasdermin-A3; Gasdermin-3", "protein_names_refseq": "bare skin; defolliculated; gasdermin 3; gasdermin-A3; gasderminA-3; recombination induced mutation 3", "tax_id": 10090, "disease": "lung adenocarcinoma (Disease Ontology:DOID:3910)", "pathway": " (mmu:450219)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "15475261;15737203;17350798;17572385;21750661;22155111;22682752;25825937;26100518;26375003;27281216;28168650;29695864;32188939;32302611;33883744;35110732;35545613;35545676", "class_list": "", "function": "Gasdermin-A3 pore formation propagates along variable pathways. Publication Status: Online-Only, [RefSeq, PubMed]; Pore-forming protein that causes membrane permeabilization and pyroptosis (PubMed:26375003, PubMed:27281216, PubMed:35545613). Released upon cleavage by some bacterial effector protein, and binds to membrane inner leaflet lipids (By similarity). Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, allowing the release of mature interleukin-1 (IL1B and IL18) and triggering pyroptosis (PubMed:27281216, PubMed:33883744, PubMed:35545613). Binds to membrane inner leaflet lipids, including bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate, as well as phosphatidylinositol (3,4,5)-bisphosphate, and more weakly to monophosphorylated phosphatidylinositols (PubMed:27281216). Also binds to bacterial and mitochondrial lipids, including cardiolipin, and exhibits bactericidal activity (PubMed:27281216, PubMed:29695864). Plays a role in the transition from catagen to telogen at the end of hair follicle morphogenesis, possibly by regulating hair follicle stem cell niche maintenance (PubMed:15475261, PubMed:15737203, PubMed:17572385, PubMed:22155111, PubMed:32302611). Also required for mammary gland development (PubMed:28168650)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Precursor of a pore-forming protein involved in the transition from catagen to telogen at the end of hair follicle morphogenesis (PubMed:15475261, PubMed:26375003, PubMed:27281216). This form constitutes the precursor of the pore: upon cleavage, the released N-terminal moiety (Gasdermin-A3, N-terminal) binds to membranes and forms pores, triggering pyroptosis (PubMed:26375003, PubMed:27281216, PubMed:35545613). This form acts as a sensor of infection: activation is triggered by cleavage by some bacterial effector protein, which releases the N-terminal moiety (Gasdermin-A3, N-terminal) (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 21, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A4X5", "ec_number_list": [], "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0070273 phosphatidylinositol-4-phosphate binding;GO:0001786 phosphatidylserine binding;GO:0022829 wide pore channel activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0036331 avascular cornea development in camera-type eye;GO:0051886 negative regulation of timing of anagen;GO:0043065 positive regulation of apoptotic process;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:2001238 positive regulation of extrinsic apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q5Y4Y6-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BH60-1", "uniprot_id": [ { "id": "GOPC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BH60", "type": "external" } ], "mass": 50662.0, "length": 463, "protein_name": "Golgi-associated PDZ and coiled-coil motif-containing protein", "gene_name": "Gopc", "organism": "Mouse", "refseq_name": "Golgi-associated PDZ and coiled-coil motif-containing protein isoform a", "refseq_ac": [ { "id": "NP_001186201", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186201", "type": "external" } ], "gene_names_uniprotkb": "Gopc; Cal", "gene_names_refseq": "2210402P09Rik; CAL; FIG; GOPC1; Gopc; PIST", "protein_names_uniprotkb": "Golgi-associated PDZ and coiled-coil motif-containing protein; CFTR-associated ligand; PDZ protein interacting specifically with TC10; PIST", "protein_names_refseq": "CFTR-associated ligand; Golgi-associated PDZ and coiled-coil motif-containing protein isoform a; PDZ domain-containing protein PIST; PDZ protein interacting specifically with TC10; golgi-associated PDZ and coiled-coil motif-containing protein", "tax_id": 10090, "disease": "azoospermia (Disease Ontology:DOID:14227); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:94221); (R-MMU-5627083); (R-MMU-9013406)", "pathway_count": 3, "publication_count": 18, "publication_id_list": "11162552;11384996;11520064;12149515;12372286;12471024;12885772;15136571;15317815;16452087;21183079;21750661;28339613;30084848;31219806;33359402;34383253;34428180", "class_list": "", "function": "Plays a role in intracellular protein trafficking and degradation (PubMed:12149515). May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels (PubMed:15317815). May also regulate the intracellular trafficking of the ADR1B receptor (By similarity). May play a role in autophagy (PubMed:12372286). Together with MARCHF2 mediates the ubiquitination and lysosomal degradation of CFTR (By similarity). Overexpression results in CFTR intracellular retention and degradation in the lysosomes (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Predominantly localized at the trans-Golgi region in round spermatids; male mice in which GOPC has been disrupted are infertile with globozoospermia, [RefSeq, PubMed]; The ARFRP1-dependent Golgi scaffolding protein GOPC is required for insulin secretion from pancreatic beta-cells., [RefSeq, PubMed]; The Golgi-Associated PDZ Domain Protein Gopc/PIST Is Required for Synaptic Targeting of mGluR5., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BSV4;Q920R1;Q9ET11", "ec_number_list": [], "go_molecular_function": "GO:0005109 frizzled binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0044325 transmembrane transporter binding;GO:0019905 syntaxin binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:0015031 protein transport;GO:0006914 autophagy;GO:2000009 negative regulation of protein localization to cell surface;GO:0007289 spermatid nucleus differentiation;GO:0010360 negative regulation of anion channel activity", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q8BH60-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BN78-1", "uniprot_id": [ { "id": "KAISO_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BN78", "type": "external" } ], "mass": 74050.0, "length": 671, "protein_name": "Transcriptional regulator Kaiso", "gene_name": "Zbtb33", "organism": "Mouse", "refseq_name": "transcriptional regulator Kaiso", "refseq_ac": [ { "id": "NP_001072981", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001072981", "type": "external" } ], "gene_names_uniprotkb": "Zbtb33; Kaiso", "gene_names_refseq": "E130014G12Rik; Kaiso; Zbtb33; Znf-kaiso", "protein_names_uniprotkb": "Transcriptional regulator Kaiso; Zinc finger and BTB domain-containing protein 33", "protein_names_refseq": "transcriptional regulator Kaiso; zinc finger and BTB domain-containing protein 33; zinc finger transcription factor Kaiso", "tax_id": 10090, "disease": "", "pathway": " (mmu:56805)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10207085;12087177;15138284;15282317;15543138;15564377;15817151;15953356;21750661;25428506;25605945;30084848;30779550;31219806;34097677;34428180;34983288", "class_list": "", "function": "Deletion of murine Rhoh leads to de-repression of Bcl-6 via decreased KAISO levels and accelerates a malignancy phenotype in a murine model of lymphoma., [RefSeq, PubMed]; P120-catenin and Kaiso are essential components of a new developmental gene regulatory pathway that controls vertebrate morphogenesis., [RefSeq, PubMed]; These results provide the first experimental evidence that rapsyn is a direct sequence-specific target of Kaiso and delta-catenin., [RefSeq, PubMed]; Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). May recruit the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. Contributes to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2. Represses expression of MMP7 in conjunction with transcriptional corepressors CBFA2T3, CBFA2T2 and RUNX1T1 (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]; [Zbtb33 Gene Knockout Changes Transcription of the Fgf9, Fgfr3, small es, Cyrillic-capital EM, Cyrillicsmall u, Cyrillicsmall es, Cyrillic and FoxG1 Genes in the Developing Mouse Brain]., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C226;Q9WTZ7", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0008327 methyl-CpG binding;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0002682 regulation of immune system process;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q8BN78-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52332-1", "uniprot_id": [ { "id": "JAK1_MOUSE", "url": "https://www.uniprot.org/uniprot/P52332", "type": "external" } ], "mass": 133367.0, "length": 1153, "protein_name": "Tyrosine-protein kinase JAK1", "gene_name": "Jak1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Jak1", "gene_names_refseq": "", "protein_names_uniprotkb": "Tyrosine-protein kinase JAK1; 2.7.10.2; JAK-1; Janus kinase 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); sciatic neuropathy (Disease Ontology:DOID:11446); endometrial cancer (Disease Ontology:DOID:1380); disease of cellular proliferation (Disease Ontology:DOID:14566); cancer (Disease Ontology:DOID:162); transient cerebral ischemia (Disease Ontology:DOID:224); ovarian cancer (Disease Ontology:DOID:2394); hematologic cancer (Disease Ontology:DOID:2531); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); lung non-small cell carcinoma (Disease Ontology:DOID:3908); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603); hepatocellular carcinoma (Disease Ontology:DOID:684); systemic lupus erythematosus (Disease Ontology:DOID:9074); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (R-MMU-1059683); (R-MMU-110056); (R-MMU-112411); (R-MMU-1169408); (R-MMU-1266695); (R-MMU-5673001); (R-MMU-5684996); (R-MMU-6783783); (R-MMU-6785807); (R-MMU-6788467); (R-MMU-877300); (R-MMU-877312); (R-MMU-8854691); (R-MMU-8983432); (R-MMU-8984722); (R-MMU-8985947); (R-MMU-9020558); (R-MMU-9020591); (R-MMU-9020956); (R-MMU-9020958); (R-MMU-909733); (R-MMU-912526); (R-MMU-912694); (R-MMU-9674555); (R-MMU-9705462); (R-MMU-9732724); (R-MMU-9931295); (R-MMU-9958825)", "pathway_count": 28, "publication_count": 16, "publication_id_list": "12738762;16479539;1709722;17322886;21750661;2466296;2482828;26495903;30899004;31219806;34203471;34428180;36210013;8272873;8331382;9710225", "class_list": "", "function": "Non-membrane spanning protein tyrosine kinase that phosphorylates signal-transducing subunits of cytokine receptor complexes like IL2RB, IL10RA, IFNAR2, IL6ST, LIFR, OSMR and IL31RA (PubMed:8272873). Functionnally, is involved in the IFN-alpha/beta/gamma signal pathway. Mechanistically, in response to interferon-binding to IFNAR1-IFNAR2 heterodimer, phosphorylates and activates its binding partner IFNAR2, creating docking sites for STAT proteins. Directly phosphorylates STAT proteins but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors. Involved in the MT-RNR2/humanin-mediated signaling pathway leading to STAT3 phosphorylation. Binding of CNTF or the CLCF1/CLF heterodimer to CNTFR leads to IL6ST/gp130-LIFR dimerization followed by activation of JAK1 and JAK2 which in turns phosphorylate IL6ST/gp130 and LIFR. The tyrosine phosphorylated signaling receptors serve in turn as docking proteins for STAT3. Involved in the oncostatin-M-mediated signaling pathway through both type I OSM receptor complex (heterodimers composed of LIFR and IL6ST) and type II OSM receptor complex (heterodimers composed of OSMR and IL6ST) (By similarity). Involved in the Interleukin-31-mediated signaling pathway through the IL31 receptor complex (heterodimers composed of OSMR and IL31RA) (By similarity)., [UniProtKB, UniProtKB, PubMed]; Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor as well as interleukin (IL)-10 receptor. Kinase partner for the type I interferon receptor IFNAR2. In response to interferon-binding to IFNAR1-IFNAR2 heterodimer, phosphorylates and activates its binding partner IFNAR2, creating docking sites for STAT proteins. Directly phosphorylates STAT proteins but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 1, "disease_count": 16, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q62126", "ec_number_list": [ { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "6.3.2.n3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.n3", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" } ], "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031234 extrinsic component of cytoplasmic side of plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0035771 interleukin-4-mediated signaling pathway;GO:0038110 interleukin-2-mediated signaling pathway;GO:1903672 positive regulation of sprouting angiogenesis;GO:0150105 protein localization to cell-cell junction;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P52332-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91W40-1", "uniprot_id": [ { "id": "KLC3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91W40", "type": "external" } ], "mass": 56006.0, "length": 508, "protein_name": "Kinesin light chain 3", "gene_name": "Klc3", "organism": "Mouse", "refseq_name": "kinesin light chain 3 isoform a", "refseq_ac": [ { "id": "NP_001272967", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001272967", "type": "external" } ], "gene_names_uniprotkb": "Klc3", "gene_names_refseq": "Klc3; Klct", "protein_names_uniprotkb": "Kinesin light chain 3", "protein_names_refseq": "kinesin light chain 3 isoform a", "tax_id": 10090, "disease": "Alzheimer's disease 1 (Disease Ontology:DOID:0080348)", "pathway": " (mmu:232943); (R-MMU-2132295); (R-MMU-5625970); (R-MMU-6811434); (R-MMU-983189)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "11319135;21183079;21750661;22561200;28003339;35547804;35961787;36210013;37776549", "class_list": "", "function": "KLC3 Regulates Ciliary Trafficking and Cyst Progression in CILK1 Deficiency-Related Polycystic Kidney Disease., [RefSeq, PubMed]; KLC3 plays a role during spermiogenesis in the development of the midpiece and in the normal function of spermatozoa, [RefSeq, PubMed]; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Plays a role during spermiogenesis in the development of the sperm tail midpiece and in the normal function of spermatozoa (PubMed:22561200). May play a role in the formation of the mitochondrial sheath formation in the developing spermatid midpiece (PubMed:22561200)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport., [UniProtKB, UniProtKB]; Targeted mutation and inactivation of the kinesin light chain 3 protein-encoding gene have no impact on mouse fertilitydagger., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TZ56", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0019894 kinesin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005874 microtubule;GO:0031514 motile cilium;GO:0035253 ciliary rootlet", "go_biological_process": "GO:0007283 spermatogenesis;GO:0008088 axo-dendritic transport;GO:0007286 spermatid development;GO:0007018 microtubule-based movement;GO:0042073 intraciliary transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q91W40-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46099-1", "uniprot_id": [ { "id": "KLF1_MOUSE", "url": "https://www.uniprot.org/uniprot/P46099", "type": "external" } ], "mass": 37757.0, "length": 358, "protein_name": "Krueppel-like factor 1", "gene_name": "Klf1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Klf1; Elkf", "gene_names_refseq": "", "protein_names_uniprotkb": "Krueppel-like factor 1; EKLF; Erythroid krueppel-like transcription factor", "protein_names_refseq": "", "tax_id": 10090, "disease": "congenital dyserythropoietic anemia type IVb (Disease Ontology:DOID:0051002); chromosome 5q deletion syndrome (Disease Ontology:DOID:0090016); congenital dyserythropoietic anemia type IVa (Disease Ontology:DOID:0111400); beta thalassemia (Disease Ontology:DOID:12241); hereditary spherocytosis (Disease Ontology:DOID:12971); Diamond-Blackfan anemia (Disease Ontology:DOID:1339); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (mmu:16596)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10671200;11259590;15542849;17938210;21750661;24129315;31126231;31818881;34428180;7565748;7682653;9722526", "class_list": "", "function": "Transcription regulator of erythrocyte development. Binds to the CACCC box in the beta-globin gene promoter and activates transcription. Probably serves as a general switch factor for erythroid development. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 12, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O70261", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0019904 protein domain specific binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0043249 erythrocyte maturation;GO:0035162 embryonic hemopoiesis;GO:0001701 in utero embryonic development;GO:0001889 liver development;GO:0006338 chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P46099-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99N43-1", "uniprot_id": [ { "id": "KREM1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99N43", "type": "external" } ], "mass": 51673.0, "length": 473, "protein_name": "Kremen protein 1", "gene_name": "Kremen1", "organism": "Mouse", "refseq_name": "kremen protein 1 precursor", "refseq_ac": [ { "id": "NP_115772", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_115772", "type": "external" } ], "gene_names_uniprotkb": "Kremen1; Kremen", "gene_names_refseq": "Kremen1; Kremen; Krm1", "protein_names_uniprotkb": "Kremen protein 1; Dickkopf receptor; Kringle domain-containing transmembrane protein 1; Kringle-containing protein marking the eye and the nose", "protein_names_refseq": "dickkopf receptor; kremen protein 1 precursor; kremen protein 1; kringle domain-containing transmembrane protein 1; kringle-coding gene marking the eye and the nose; kringle-containing protein marking the eye and the nose", "tax_id": 10090, "disease": "ectodermal dysplasia 13 (Disease Ontology:DOID:0111650)", "pathway": " (mmu:84035); (R-MMU-3772470)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;11267660;12050670;18505822;21750661;26206087;27550540;30084848;34428180;37788227;37828378;38945954", "class_list": "", "function": "Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling, [RefSeq, PubMed]; Noncoding RNA regulates the expression of Krm1 and Dkk2 to synergistically affect aortic valve lesions., [RefSeq, PubMed]; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6 (PubMed:12050670). In the absence of DKK1, potentiates Wnt-beta-catenin signaling by maintaining LRP5 or LRP6 at the cell membrane (By similarity). Can trigger apoptosis in a Wnt-independent manner and this apoptotic activity is inhibited upon binding of the ligand DKK1 (PubMed:26206087). Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation (PubMed:18505822). Modulates cell fate decisions in the developing cochlea with an inhibitory role in hair cell fate specification (PubMed:27550540)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]; VP2 residue N142 of coxsackievirus A10 is critical for the interaction with KREMEN1 receptor and neutralizing antibodies and the pathogenicity in mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9585, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q640Q6", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007165 signal transduction;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0006915 apoptotic process;GO:0016055 Wnt signaling pathway;GO:0060173 limb development", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q99N43-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88447-1", "uniprot_id": [ { "id": "KLC1_MOUSE", "url": "https://www.uniprot.org/uniprot/O88447", "type": "external" } ], "mass": 61450.0, "length": 541, "protein_name": "Kinesin light chain 1", "gene_name": "Klc1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Klc1; Kns2", "gene_names_refseq": "", "protein_names_uniprotkb": "Kinesin light chain 1; KLC 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "Alzheimer's disease 1 (Disease Ontology:DOID:0080348); Alzheimer's disease (Disease Ontology:DOID:10652); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378)", "pathway": " (R-MMU-2132295); (R-MMU-5625970); (R-MMU-6811434); (R-MMU-983189)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;15767678;17947660;19861499;21183079;21750661;22645316;28135057;31219806;34428180;36210013;9624122", "class_list": "", "function": "Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity., [UniProtKB, UniProtKB]; Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019894 kinesin binding;GO:0015631 tubulin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule;GO:0016020 membrane;GO:0030424 axon", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0007155 cell adhesion;GO:0008088 axo-dendritic transport;GO:0007018 microtubule-based movement;GO:0035418 protein localization to synapse", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "O88447-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WV86-1", "uniprot_id": [ { "id": "KTNA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WV86", "type": "external" } ], "mass": 55949.0, "length": 491, "protein_name": "Katanin p60 ATPase-containing subunit A1", "gene_name": "Katna1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Katna1; KATNA1", "gene_names_refseq": "", "protein_names_uniprotkb": "Katanin p60 ATPase-containing subunit A1; 5.6.1.1; Katanin p60 subunit A1; Lipotransin; p60 katanin", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:23924)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10445032;15215300;21750661;28436967;29395789;34428180", "class_list": "", "function": "Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. The function in regulating microtubule dynamics at spindle poles seems to depend on the association of the katanin KATNA1:KATNB1 complex with ASPM which recruits it to microtubules. Reversely KATNA1:KATNB1 can enhance ASPM blocking activity on microtubule minus-end growth. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth., [UniProtKB, HAMAP, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008568 microtubule severing ATPase activity;GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0046982 protein heterodimerization activity;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0008352 katanin complex;GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005811 lipid droplet", "go_biological_process": "GO:0051013 microtubule severing;GO:0051301 cell division;GO:0001764 neuron migration;GO:0010977 negative regulation of neuron projection development;GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9WV86-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BZT9-1", "uniprot_id": [ { "id": "LACC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BZT9", "type": "external" } ], "mass": 47514.0, "length": 430, "protein_name": "Purine nucleoside phosphorylase LACC1", "gene_name": "Lacc1", "organism": "Mouse", "refseq_name": "purine nucleoside phosphorylase LACC1", "refseq_ac": [ { "id": "NP_766076", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766076", "type": "external" } ], "gene_names_uniprotkb": "Lacc1; 9030625A04Rik; Famin", "gene_names_refseq": "9030625A04Rik; Lacc1", "protein_names_uniprotkb": "Purine nucleoside phosphorylase LACC1; 2.4.2.1; 2.4.2.28; 3.5.4.4; 4.3.3.-; Adenosine deaminase LACC1; Fatty acid metabolism-immunity nexus; Guanosine phosphorylase LACC1; Isocyanic acid synthase; Laccase domain-containing protein 1; S-methyl-5'-thioadenosine phosphorylase LACC1", "protein_names_refseq": "S-methyl-5'-thioadenosine phosphorylase LACC1; adenosine deaminase LACC1; fatty acid metabolism-immunity nexus; guanosine phosphorylase LACC1; isocyanic acid synthase; laccase (multicopper oxidoreductase) domain containing 1; laccase domain-containing protein 1; purine nucleoside phosphorylase LACC1", "tax_id": 10090, "disease": "systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676)", "pathway": " (mmu:210808)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "21540332;21750661;22645316;25428506;27478939;30084848;30510070;31978345;32693188;34428180;35978195;37848840;38064597", "class_list": "", "function": "LACC1 Promoted Nerve Injury in an Anesthesia-Induced Cognitive Disorder Model via RIP2 Expression through ROS-NOD2 Induction., [RefSeq, PubMed]; LACC1 bridges NOS2 and polyamine metabolism in inflammatory macrophages. Erratum:[Nature. 2023 Jun;618(7965):E21. doi: 10.1038/s41586-023-06244-9. PMID: 37231312], [RefSeq, PubMed]; LACC1 regulates changes in the intestinal flora in a mouse model of inflammatory bowel disease. Publication Status: Online-Only, [RefSeq, PubMed]; Myeloid Cell Expression of LACC1 Is Required for Bacterial Clearance and Control of Intestinal Inflammation., [RefSeq, PubMed]; Purine nucleoside enzyme that catalyzes the phosphorolysis of adenosine, guanosine and inosine nucleosides, yielding D-ribose 1-phosphate and the respective free bases, adenine, guanine and hypoxanthine (By similarity). Also catalyzes the phosphorolysis of S-methyl-5'-thioadenosine into adenine and S-methyl-5-thio-alpha-D-ribose 1-phosphate (By similarity). Also has adenosine deaminase activity (By similarity). Acts as a regulator of innate immunity in macrophages by modulating the purine nucleotide metabolism, thereby regulating the metabolic function and bioenergetic state of macrophages (PubMed:27478939, PubMed:31978345). Enables a purine nucleotide cycle between adenosine and inosine monophosphate and adenylosuccinate that prevents cytoplasmic acidification and balances the cytoplasmic-mitochondrial redox interface (PubMed:31978345). The purine nucleotide cycle consumes aspartate and releases fumarate in a manner involving fatty acid oxidation and ATP-citrate lyase activity (PubMed:31978345). Participates in pattern recognition receptor-induced cytokines in macrophages: associates with the NOD2-signaling complex and promotes optimal NOD2-induced signaling, cytokine secretion and bacterial clearance (By similarity). Localizes to the endoplasmic reticulum upon PRR stimulation of macrophages and associates with endoplasmic reticulum-stress sensors, promoting the endoplasmic reticulum unfolded protein response (UPR) (By similarity). Does not show laccase activity (By similarity). Component of L-arginine metabolism in activated macrophages supporting anti-inflammatory and antibacterial macrophage effector functions. Cleaves L-citrulline, a product of L-arginine metabolized via NOS2, to yield isocyanate, a reactive carbonyl species-like cytotoxin, and L-ornithine, a precursor in polyamine biosynthesis. Through L-ornithine controls cellular polyamine pools likely triggering polyamine-mediated proinflammatory cytokine suppression and autophagy stimulation (PubMed:35978195). Directly interacts with components of autophagy machinery to regulate macrophage metabolism and bacterial phagocytosis. Acts downstream of the energy sensor AMP-activated protein kinase (AMPK) to promote autophagy associated to lipid droplets generation providing fatty acids for mitochondrial respiration (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; This study shows that LACC1 regulates TNF and IL-17 in mouse models of arthritis and inflammation, [RefSeq, PubMed]; This study shows that Lacc1 is a central regulator of the metabolic function and bioenergetic state of macrophages that is under evolutionary selection and determines the risk of inflammatory and infectious disease, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q14AQ3;Q3U600", "ec_number_list": [ { "id": "3.5.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "2.4.2.28", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.28", "type": "external" }, { "id": "4.3.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.3.3.-", "type": "external" } ], "go_molecular_function": "GO:0004000 adenosine deaminase activity;GO:0005507 copper ion binding;GO:0016829 lyase activity;GO:0004731 purine-nucleoside phosphorylase activity;GO:0017061 S-methyl-5-thioadenosine phosphorylase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005777 peroxisome;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0002221 pattern recognition receptor signaling pathway;GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0050727 regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8BZT9-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63318-1", "uniprot_id": [ { "id": "KPCG_MOUSE", "url": "https://www.uniprot.org/uniprot/P63318", "type": "external" } ], "mass": 78358.0, "length": 697, "protein_name": "Protein kinase C gamma type", "gene_name": "Prkcg", "organism": "Mouse", "refseq_name": "protein kinase C gamma type isoform 1", "refseq_ac": [ { "id": "NP_035232", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035232", "type": "external" } ], "gene_names_uniprotkb": "Prkcg; Pkcc; Pkcg; Prkcc", "gene_names_refseq": "PKCgamma; Pkcc; Prkcc; Prkcg", "protein_names_uniprotkb": "Protein kinase C gamma type; 2.7.11.13; PKC-gamma", "protein_names_refseq": "PKC-gamma; protein kinase C gamma type isoform 1; protein kinase C gamma type", "tax_id": 10090, "disease": "spinocerebellar ataxia 14 (Disease Ontology:DOID:0050964); alcohol use disorder (Disease Ontology:DOID:1574); middle cerebral artery infarction (Disease Ontology:DOID:3525)", "pathway": " (mmu:18752); (R-MMU-111933); (R-MMU-114516); (R-MMU-416993); (R-MMU-5099900); (R-MMU-76005)", "pathway_count": 6, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;11246146;11278552;11356858;11731061;17114649;17904530;18473171;21183079;21750661;23185022;26133792;33300544;34428180;35984892;8269509;8428669;8548809;9323205", "class_list": "", "function": "Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity. May be involved in desensitization of mu-type opioid receptor-mediated G protein activation in the spinal cord, and may be critical for the development and/or maintenance of morphine-induced reinforcing effects in the limbic forebrain. May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors. May also contribute to chronic morphine-induced changes in nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors. During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury. Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing cerebellum. Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43 (GJA1/CX43), resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress. Phosphorylates p53/TP53 and promotes p53/TP53-dependent apoptosis in response to DNA damage. Involved in the phase resetting of the cerebral cortex circadian clock during temporally restricted feeding. Stabilizes the core clock component BMAL1 by interfering with its ubiquitination, thus suppressing its degradation, resulting in phase resetting of the cerebral cortex clock (PubMed:23185022). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "P05697", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.11.15", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.15", "type": "external" }, { "id": "2.7.11.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.16", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0004712 protein serine/threonine/tyrosine kinase activity", "go_cellular_component": "GO:0044305 calyx of Held;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0032425 positive regulation of mismatch repair;GO:0060384 innervation;GO:0032095 regulation of response to food;GO:0007611 learning or memory;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P63318-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UQ44-1", "uniprot_id": [ { "id": "IQGA2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UQ44", "type": "external" } ], "mass": 180528.0, "length": 1575, "protein_name": "Ras GTPase-activating-like protein IQGAP2", "gene_name": "Iqgap2", "organism": "Mouse", "refseq_name": "ras GTPase-activating-like protein IQGAP2", "refseq_ac": [ { "id": "NP_081987", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081987", "type": "external" } ], "gene_names_uniprotkb": "Iqgap2", "gene_names_refseq": "4933417J23Rik; A630053O10; Iqgap2", "protein_names_uniprotkb": "Ras GTPase-activating-like protein IQGAP2", "protein_names_refseq": "ras GTPase-activating-like protein IQGAP2", "tax_id": 10090, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:544963); (R-MMU-5626467); (R-MMU-6798695); (R-MMU-9013149); (R-MMU-9013408)", "pathway_count": 5, "publication_count": 12, "publication_id_list": "17242355;18630941;21183079;25605945;28179424;31219806;34203471;34428180;36210013;37453647;37805137;39627609", "class_list": "", "function": "Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin., [UniProtKB]; Depletion of IQ motif-containing GTPase activating protein 2 (IQGAP2) reduces hepatic glycogen and impairs insulin signaling., [RefSeq, PubMed]; Found a hypomethylated region mapping to Iqgap2 (IQ motif-containing GTPase activating protein 2) and F2rl2, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005516 calmodulin binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0051015 actin filament binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0005938 cell cortex;GO:0009986 cell surface;GO:0030027 lamellipodium", "go_biological_process": "GO:0032956 regulation of actin cytoskeleton organization;GO:0034314 Arp2/3 complex-mediated actin nucleation;GO:0070493 thrombin-activated receptor signaling pathway;GO:1903479 mitotic actomyosin contractile ring assembly actin filament organization", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q3UQ44-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5DTY9-1", "uniprot_id": [ { "id": "KCD16_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5DTY9", "type": "external" } ], "mass": 48972.0, "length": 427, "protein_name": "BTB/POZ domain-containing protein KCTD16", "gene_name": "Kctd16", "organism": "Mouse", "refseq_name": "BTB/POZ domain-containing protein KCTD16", "refseq_ac": [ { "id": "NP_080411", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080411", "type": "external" } ], "gene_names_uniprotkb": "Kctd16; Gm1267; Kiaa1317", "gene_names_refseq": "2900055J20Rik; 4930434H12Rik; C030017B01Rik; Gm1267; Kctd16", "protein_names_uniprotkb": "BTB/POZ domain-containing protein KCTD16", "protein_names_refseq": "BTB/POZ domain-containing protein KCTD16", "tax_id": 10090, "disease": "", "pathway": " (mmu:383348)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;18034455;20400944;21183079;21452234;21750661;27717812;33300544", "class_list": "", "function": "Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G protein signaling of the receptors by accelerating onset and promoting desensitization., [UniProtKB, PubMed]; Data suggest that the distinct spatial and temporal distribution patterns of KCTD8, 12, 12b, and 16 underlie functional differences in native GABA(B) responses., [RefSeq, PubMed]; This study demonstrated that the Kctd16(-/-) mice exhibited less extinction of auditory fear memory relative to WT and Kctd16(+/-) mice, as well as more contextual fear memory relative to WT and, in particular, Kctd16(+/-) mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q78Y50", "ec_number_list": [], "go_molecular_function": "GO:0099579 G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential;GO:0150047 G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential", "go_cellular_component": "GO:0043235 receptor complex;GO:0045211 postsynaptic membrane;GO:0042734 presynaptic membrane;GO:0005886 plasma membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0007613 memory;GO:0051260 protein homooligomerization;GO:0001662 behavioral fear response;GO:0008277 regulation of G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q5DTY9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SVQ0-1", "uniprot_id": [ { "id": "KAT7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5SVQ0", "type": "external" } ], "mass": 70641.0, "length": 613, "protein_name": "Histone acetyltransferase KAT7", "gene_name": "Kat7", "organism": "Mouse", "refseq_name": "histone acetyltransferase KAT7 isoform 2", "refseq_ac": [ { "id": "NP_001181933", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181933", "type": "external" } ], "gene_names_uniprotkb": "Kat7; Hbo1; Myst2", "gene_names_refseq": "Hbo1; Hboa; Kat7; Myst2", "protein_names_uniprotkb": "Histone acetyltransferase KAT7; 2.3.1.48; Histone acetyltransferase binding to ORC1; Lysine acetyltransferase 7; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2; MYST-2", "protein_names_refseq": "MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2; MYST histone acetyltransferase 2; histone acetyltransferase KAT7 isoform 2; histone acetyltransferase KAT7; histone acetyltransferase MYST2; histone acetyltransferase binding to ORC1; lysine acetyltransferase 7", "tax_id": 10090, "disease": "breast cancer (Disease Ontology:DOID:1612); androgen insensitivity syndrome (Disease Ontology:DOID:4674)", "pathway": " (mmu:217127); (R-MMU-3214847)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "17954561;18029353;21149574;21183079;21750661;21753189;23319590;23806337;27733580;31219806;31827282;34428180;36210013;36942752", "class_list": "", "function": "Catalytic subunit of histone acetyltransferase HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby regulating various processes, such as gene transcription, protein ubiquitination, immune regulation, stem cell pluripotent and self-renewal maintenance and embryonic development (PubMed:21149574, PubMed:21753189, PubMed:23319590, PubMed:27733580, PubMed:31827282). Some complexes also catalyze acetylation of histone H4 at 'Lys-5', 'Lys-8' and 'Lys-12' (H4K5ac, H4K8ac and H4K12ac, respectively), regulating DNA replication initiation, regulating DNA replication initiation (By similarity). Specificity of the HBO1 complexes is determined by the scaffold subunit: complexes containing BRPF scaffold (BRPF1, BRD1/BRPF2 or BRPF3) direct KAT7/HBO1 specificity towards H3K14ac, while complexes containing JADE (JADE1, JADE2 and JADE3) scaffold direct KAT7/HBO1 specificity towards histone H4 (By similarity). H3K14ac promotes transcriptional elongation by facilitating the processivity of RNA polymerase II (PubMed:31827282). Acts as a key regulator of hematopoiesis by forming a complex with BRD1/BRPF2, directing KAT7/HBO1 specificity towards H3K14ac and promoting erythroid differentiation (By similarity). H3K14ac is also required for T-cell development (PubMed:27733580). KAT7/HBO1-mediated acetylation facilitates two consecutive steps, licensing and activation, in DNA replication initiation: H3K14ac facilitates the activation of replication origins, and histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac) facilitates chromatin loading of MCM complexes, promoting DNA replication licensing (By similarity). Acts as a positive regulator of centromeric CENPA assembly: recruited to centromeres and mediates histone acetylation, thereby preventing centromere inactivation mediated by SUV39H1, possibly by increasing histone turnover/exchange (By similarity). Involved in nucleotide excision repair: phosphorylation by ATR in response to ultraviolet irradiation promotes its localization to DNA damage sites, where it mediates histone acetylation to facilitate recruitment of XPC at the damaged DNA sites (By similarity). Acts as an inhibitor of NF-kappa-B independently of its histone acetyltransferase activity (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Circ-myh8 Promotes Pulmonary Hypertension by Recruiting KAT7 to Govern Hypoxia-Inducible Factor-1alpha Expression., [RefSeq, PubMed]; FAD24 controls DNA replication by recruiting HBO1 to origins of DNA replication and is required for MCE during adipocyte differentiation., [RefSeq, PubMed]; Plays a central role in the maintenance of leukemia stem cells in acute myeloid leukemia (AML) (PubMed:31827282). Acts by mediating acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby facilitating the processivity of RNA polymerase II to maintain the high expression of key genes, such as HOXA9 and HOXA10 that help to sustain the functional properties of leukemia stem cells (PubMed:31827282)., [UniProtKB, PubMed]; Reveal a direct regulatory connection between p53-responsive stress signaling and Hbo1-dependent chromatin pathways, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5SVQ1;Q5SVQ2;Q5SVQ3;Q5SVQ7;Q6PGC6;Q80Y65", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.1.259", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.259", "type": "external" }, { "id": "2.3.1.57", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.57", "type": "external" }, { "id": "2.3.1.80", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.80", "type": "external" }, { "id": "4.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0003688 DNA replication origin binding;GO:0043997 histone H4K12 acetyltransferase activity;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000775 chromosome, centromeric region;GO:0000785 chromatin", "go_biological_process": "GO:0001779 natural killer cell differentiation;GO:0030174 regulation of DNA-templated DNA replication initiation;GO:0072708 response to sorbitol;GO:2000278 regulation of DNA biosynthetic process;GO:2000819 regulation of nucleotide-excision repair", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q5SVQ0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BNW9-1", "uniprot_id": [ { "id": "KBTBB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BNW9", "type": "external" } ], "mass": 67946.0, "length": 633, "protein_name": "Kelch repeat and BTB domain-containing protein 11", "gene_name": "Kbtbd11", "organism": "Mouse", "refseq_name": "kelch repeat and BTB domain-containing protein 11", "refseq_ac": [ { "id": "NP_083392", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083392", "type": "external" } ], "gene_names_uniprotkb": "Kbtbd11; Kiaa0711", "gene_names_refseq": "2900016B01Rik; 4930465M17Rik; Kbtbd11; mKIAA0711", "protein_names_uniprotkb": "Kelch repeat and BTB domain-containing protein 11", "protein_names_refseq": "kelch repeat and BTB domain-containing protein 11", "tax_id": 10090, "disease": "", "pathway": " (mmu:74901)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16452087;17114649;19144319;21183079;25428506;30582777", "class_list": "", "function": "Kbtbd11 appears to be required for the differentiation of adipocytes in 3T3-L1 cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A3KME3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BNW9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D783-1", "uniprot_id": [ { "id": "KLH40_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D783", "type": "external" } ], "mass": 69589.0, "length": 621, "protein_name": "Kelch-like protein 40", "gene_name": "Klhl40", "organism": "Mouse", "refseq_name": "kelch-like protein 40", "refseq_ac": [ { "id": "NP_082478", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082478", "type": "external" } ], "gene_names_uniprotkb": "Klhl40; Kbtbd5", "gene_names_refseq": "2310024D23Rik; Kbtbd5; Klhl40", "protein_names_uniprotkb": "Kelch-like protein 40; Kelch repeat and BTB domain-containing protein 5", "protein_names_refseq": "kelch repeat and BTB (POZ) domain containing 5; kelch repeat and BTB domain-containing protein 5; kelch-like protein 40", "tax_id": 10090, "disease": "nemaline myopathy 8 (Disease Ontology:DOID:0110930)", "pathway": " (mmu:72330)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;22872234;23746549;24361185;24960163;25940086", "class_list": "", "function": "Kbtbd5 regulates skeletal muscle myogenesis through the regulation of E2F1-DP1 activity, [RefSeq, PubMed]; NEB and LMOD3 were reduced in skeletal muscle of Klhl40-/- mice, providing a potential basis for the development of experimental nemaline myopathy., [RefSeq, PubMed]; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development (PubMed:25940086). The BCR(KLHL40) complex acts by mediating ubiquitination and degradation of TFDP1, thereby regulating the activity of the E2F:DP transcription factor complex (PubMed:25940086). Promotes stabilization of LMOD3 by acting as a negative regulator of LMOD3 ubiquitination; the molecular process by which it negatively regulates ubiquitination of LMOD3 is however unclear (PubMed:24960163)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; We have demonstrated that Kbtbd5 is the direct downstream target gene of the Myod family and regulates myogenic differentiation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9EHG6;Q059P8;Q3TUF0", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031674 I band;GO:0031672 A band;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0048741 skeletal muscle fiber development;GO:0031398 positive regulation of protein ubiquitination;GO:0031397 negative regulation of protein ubiquitination;GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9D783-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJ69-1", "uniprot_id": [ { "id": "KCIP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JJ69", "type": "external" } ], "mass": 30946.0, "length": 270, "protein_name": "A-type potassium channel modulatory protein KCNIP2", "gene_name": "Kcnip2", "organism": "Mouse", "refseq_name": "A-type potassium channel modulatory protein KCNIP2 isoform d", "refseq_ac": [ { "id": "NP_001263287", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263287", "type": "external" } ], "gene_names_uniprotkb": "Kcnip2; Kchip2", "gene_names_refseq": "KChIP2; Kcnip2", "protein_names_uniprotkb": "A-type potassium channel modulatory protein KCNIP2; KChIP2; Kv channel-interacting protein 2; Potassium channel-interacting protein 2", "protein_names_refseq": "A-type potassium channel modulatory protein 2; A-type potassium channel modulatory protein KCNIP2 isoform d; A-type potassium channel modulatory protein KCNIP2; potassium channel-interacting protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:80906); (R-MMU-5576894)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "11263977;11747815;11909823;15363885;15878168;19713751;20943905;21750661;23713033;36323322", "class_list": "", "function": "Inhibitory Kcnip2 neurons of the spinal dorsal horn control behavioral sensitivity to environmental cold., [RefSeq, PubMed]; KChIP2 contributes to the formation of functional mouse ventricular Kv1.5 channels Erratum:[J Mol Cell Cardiol. 2005 Oct;39(4):723], [RefSeq, PubMed]; KChIP2 transcripts were highly expressed in layer IV of the cerebral cortex and in striatum and hippocampus, but expressed at low levels in cerebellum., [RefSeq, PubMed]; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels (PubMed:20943905, PubMed:23713033). Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner (PubMed:20943905, PubMed:23713033). Involved in KCND2 and KCND3 trafficking to the cell surface (By similarity). Essential for the expression of I(To) currents in the heart (PubMed:11747815, PubMed:23713033). Required for normal protein levels of KCND2 in the heart ventricle (PubMed:23713033)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; This gene encodes a member of the voltage-gated potassium channel-interacting protein (KCNIP) family. KCNIP family members are small calcium binding proteins that commonly exhibit unique variation at their N-termini, and which modulate A-type potassium channels. This gene is predominantly expressed in the adult heart, and to a lesser extent in the brain. Disruption of this gene is associated with susceptibility to cardiac arrhythmias and lack of transient outward potassium current in ventricular myocytes, and downregulated expression is associated with cardiac hypertrophy. The encoded protein has also been implicated as a repressor of immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6DTJ2;Q8K1T8;Q8K1T9;Q8K1U0;Q8VHN4;Q8VHN5;Q8VHN6;Q9JJ68", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0015459 potassium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0005509 calcium ion binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0008076 voltage-gated potassium channel complex;GO:0071193 Kv4.2-KChIP2 channel complex", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0006936 muscle contraction;GO:0001508 action potential;GO:0060306 regulation of membrane repolarization;GO:0008016 regulation of heart contraction", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9JJ69-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGA2-1", "uniprot_id": [ { "id": "LHPL2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGA2", "type": "external" } ], "mass": 23873.0, "length": 222, "protein_name": "LHFPL tetraspan subfamily member 2 protein", "gene_name": "Lhfpl2", "organism": "Mouse", "refseq_name": "LHFPL tetraspan subfamily member 2 protein", "refseq_ac": [ { "id": "NP_766177", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766177", "type": "external" } ], "gene_names_uniprotkb": "Lhfpl2", "gene_names_refseq": "6030465B15; Lhfpl2; mKIAA0206; vgim", "protein_names_uniprotkb": "LHFPL tetraspan subfamily member 2 protein; Lipoma HMGIC fusion partner-like 2 protein", "protein_names_refseq": "LHFPL tetraspan subfamily member 2 protein; lipoma HMGIC fusion partner-like 2 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:218454); (R-MMU-114608)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;26964900;34428180", "class_list": "", "function": "Plays a role in female and male fertility. Involved in distal reproductive tract development (PubMed:26964900)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0007338 single fertilization;GO:0046545 development of primary female sexual characteristics;GO:0046546 development of primary male sexual characteristics;GO:1905516 positive regulation of fertilization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BGA2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99PI4-1", "uniprot_id": [ { "id": "LPIN3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99PI4", "type": "external" } ], "mass": 94316.0, "length": 848, "protein_name": "Phosphatidate phosphatase LPIN3", "gene_name": "Lpin3", "organism": "Mouse", "refseq_name": "phosphatidate phosphatase LPIN3", "refseq_ac": [ { "id": "NP_001186047", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186047", "type": "external" } ], "gene_names_uniprotkb": "Lpin3", "gene_names_refseq": "9130206L11Rik; Lpin3; mKIAA4023", "protein_names_uniprotkb": "Phosphatidate phosphatase LPIN3; 3.1.3.4; Lipin-3", "protein_names_refseq": "phosphatidate phosphatase LPIN3", "tax_id": 10090, "disease": "myoglobinuria (Disease Ontology:DOID:0080108); lipid metabolism disorder (Disease Ontology:DOID:3146); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:64899); (R-MMU-1483191); (R-MMU-1483213); (R-MMU-4419969); (R-MMU-75109)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "11138012;17158099;17242355;21183079;21750661;28982975;30084848;30507612;30779550;34428180;37776435", "class_list": "", "function": "Data suggest that phosphorylation does not affect catalytic activity of lipin 3 or its ability to associate with phosphatidic acid in vitro; different polybasic domains in lipin 1 and lipin 3 are responsible for phospho-regulation on the former but not the latter enzyme., [RefSeq, PubMed]; Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression and nucleocytoplasmic localization of Lipin1., [RefSeq, PubMed]; Lipin-3 exhibits phosphatidate phosphatase type-1 (PAP1) activity, which has a key role in glycerolipid synthesis., [RefSeq, PubMed]; Magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis therefore regulates fatty acid metabolism., [UniProtKB, PubMed]; These data implicate lipin 2/3 as a control point for enterocyte phospholipid homeostasis and chylomicron biogenesis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TQ75;Q8C7R9", "ec_number_list": [ { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.4", "type": "external" }, { "id": "3.6.1.75", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.75", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.106", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.106", "type": "external" } ], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008195 phosphatidate phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0009062 fatty acid catabolic process;GO:0032869 cellular response to insulin stimulus;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0019432 triglyceride biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q99PI4-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K0B3-1", "uniprot_id": [ { "id": "LRC66_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K0B3", "type": "external" } ], "mass": 97626.0, "length": 872, "protein_name": "Leucine-rich repeat-containing protein 66", "gene_name": "Lrrc66", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing protein 66 precursor", "refseq_ac": [ { "id": "NP_705796", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_705796", "type": "external" } ], "gene_names_uniprotkb": "Lrrc66", "gene_names_refseq": "Lrrc66", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 66", "protein_names_refseq": "leucine-rich repeat-containing protein 66 precursor; leucine-rich repeat-containing protein 66", "tax_id": 10090, "disease": "", "pathway": " (mmu:231296)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21183079;21750661", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8K0B3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z175-1", "uniprot_id": [ { "id": "LOXL3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z175", "type": "external" } ], "mass": 83740.0, "length": 754, "protein_name": "Lysyl oxidase homolog 3", "gene_name": "Loxl3", "organism": "Mouse", "refseq_name": "lysyl oxidase homolog 3 precursor", "refseq_ac": [ { "id": "NP_038614", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038614", "type": "external" } ], "gene_names_uniprotkb": "Loxl3; Lor2", "gene_names_refseq": "Lor2; Loxl2; Loxl3", "protein_names_uniprotkb": "Lysyl oxidase homolog 3; 1.4.3.-; 1.4.3.13; Lysyl oxidase-like protein 3; Lysyl oxidase-related protein 2", "protein_names_refseq": "lysyl oxidase homolog 3 precursor; lysyl oxidase homolog 3; lysyl oxidase-like 2; lysyl oxidase-like protein 3; lysyl oxidase-related protein 2", "tax_id": 10090, "disease": "myopia (Disease Ontology:DOID:11830)", "pathway": " (mmu:16950); (R-MMU-1566948); (R-MMU-2243919)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;18250455;20484733;21750661;25428506;26307084;26954549;27645581;28065600;31219806;31599954;34428180;35628534;36610533;37253718;9927484", "class_list": "", "function": "Evidence that LOXL3 is indispensable for mouse palatogenesis and vertebral column development, [RefSeq, PubMed]; Loxl2 and Loxl3 Paralogues Play Redundant Roles during Mouse Development. Publication Status: Online-Only, [RefSeq, PubMed]; Lysyl oxidase-like 3 restrains mitochondrial ferroptosis to promote liver cancer chemoresistance by stabilizing dihydroorotate dehydrogenase. Publication Status: Online-Only, [RefSeq, PubMed]; Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine)., [UniProtKB, UniProtKB]; Progressive degeneration of the retina in Loxl3 mutant mouse model of Stickler syndrome., [RefSeq, PubMed]; Protein-lysine 6-oxidase that mediates the oxidation of peptidyl lysine residues to allysine in target proteins (PubMed:26954549). Catalyzes the post-translational oxidative deamination of peptidyl lysine residues in precursors of elastin and different types of collagens, a prerequisite in the formation of cross-links between collagens and elastin (PubMed:26307084). Required for somite boundary formation by catalyzing oxidation of fibronectin (FN1), enhancing integrin signaling in myofibers and their adhesion to the myotendinous junction (MTJ) (PubMed:26954549). Acts as a regulator of inflammatory response by inhibiting differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): acts by interacting with STAT3 in the nucleus and catalyzing both deacetylation and oxidation of lysine residues on STAT3, leading to disrupt STAT3 dimerization and inhibit STAT3 transcription activity (PubMed:28065600). Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated (By similarity). Also able to catalyze deacetylation of lysine residues on STAT3 (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; That lysyl oxidase-like 3 is a key regulator of integrin signaling that ensures localized control of the cascade, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q91VN8;Q9JJ39", "ec_number_list": [ { "id": "1.4.3.13", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.13", "type": "external" }, { "id": "3.4.24.19", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.19", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "1.4.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.-", "type": "external" } ], "go_molecular_function": "GO:0005507 copper ion binding;GO:0001968 fibronectin binding;GO:0004720 protein-lysine 6-oxidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0021510 spinal cord development;GO:0030324 lung development;GO:0045892 negative regulation of DNA-templated transcription;GO:0030199 collagen fibril organization", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9Z175-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PB66-1", "uniprot_id": [ { "id": "LPPRC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PB66", "type": "external" } ], "mass": 156615.0, "length": 1392, "protein_name": "Leucine-rich PPR motif-containing protein, mitochondrial", "gene_name": "Lrpprc", "organism": "Mouse", "refseq_name": "leucine-rich PPR motif-containing protein, mitochondrial precursor", "refseq_ac": [ { "id": "NP_082509", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082509", "type": "external" } ], "gene_names_uniprotkb": "Lrpprc; Lrp130", "gene_names_refseq": "3110001K13Rik; Gp130; Lrp130; Lrpprc; Lsfc", "protein_names_uniprotkb": "Leucine-rich PPR motif-containing protein, mitochondrial; 130 kDa leucine-rich protein; LRP 130; mLRP130", "protein_names_refseq": "130 kDa leucine-rich protein; leucine rich protein LRP130; leucine-rich PPR motif-containing protein, mitochondrial precursor; leucine-rich PPR motif-containing protein, mitochondrial", "tax_id": 10090, "disease": "French Canadian Leigh disease (Disease Ontology:DOID:0111180); Leigh disease (Disease Ontology:DOID:3652)", "pathway": " (mmu:72416)", "pathway_count": 1, "publication_count": 29, "publication_id_list": "10.1101/2023.09.13.557529;12071956;15081402;17050673;18299400;19262567;19372376;21750661;21952136;22872234;23576753;25428506;26740625;28325843;30084848;30779550;31219806;34203471;34413467;34428180;34887587;35820727;36210013;36288343;37453647;37507081;39627609;39927985;40885482", "class_list": "", "function": "Adaptive optimization of the OXPHOS assembly line partially compensates lrpprc-dependent mitochondrial translation defects in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Associates with mRNA/mRNP complexes at the outside of nuclear/endoplasmic reticulum, and plays a role in control of mRNA metabolisms, [RefSeq, PubMed]; Includes the study of an upstream ORF in this gene, and shows that it functions to reduce protein levels by ~74%., [RefSeq, PubMed]; LRP130 may function in stabilizing minisatellite DNA sequences., [RefSeq, PubMed]; May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. Positively modulates nuclear export of mRNAs containing the EIF4E sensitivity element (4ESE) by binding simultaneously to both EIF4E and the 4ESE and acting as a platform for assembly for the RNA export complex (By similarity). Also binds to exportin XPO1/CRM1 to engage the nuclear pore and traffic the bound mRNAs to the cytoplasm (By similarity). May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters (By similarity). Binds single-stranded DNA. Required for maintaining mitochondrial potential (By similarity). Suppresses the initiation of basal levels of autophagy and mitophagy by sustaining BCL2 levels (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8K4V0;Q9CRX4", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0031625 ubiquitin protein ligase binding;GO:0048487 beta-tubulin binding;GO:0003730 mRNA 3'-UTR binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006914 autophagy;GO:0070129 regulation of mitochondrial translation;GO:0097222 mitochondrial mRNA polyadenylation;GO:0051028 mRNA transport", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "Q6PB66-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q01965-1", "uniprot_id": [ { "id": "LY9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q01965", "type": "external" } ], "mass": 73143.0, "length": 654, "protein_name": "T-lymphocyte surface antigen Ly-9", "gene_name": "Ly9", "organism": "Mouse", "refseq_name": "T-lymphocyte surface antigen Ly-9 isoform 2", "refseq_ac": [ { "id": "NP_001264897", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264897", "type": "external" } ], "gene_names_uniprotkb": "Ly9; Ly-9", "gene_names_refseq": "CD229; Lgp100; Ly-9; Ly9; SLAMF3; T100", "protein_names_uniprotkb": "T-lymphocyte surface antigen Ly-9; Cell surface molecule Ly-9; Lymphocyte antigen 9; SLAM family member 3; SLAMF3; Signaling lymphocytic activation molecule 3", "protein_names_refseq": "SLAM family member 3; T-lymphocyte surface antigen Ly-9 isoform 2; T-lymphocyte surface antigen Ly-9; cell surface molecule Ly-9; signaling lymphocytic activation molecule 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:17085)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;10970093;11465105;1506686;16075062;19144319;19648922;21750661;23225888;23914190;26495903;31057553;31219806;32152506;35061505", "class_list": "", "function": "SLAMF3 and SLAMF4 are immune checkpoints that constrain macrophage phagocytosis of hematopoietic tumors., [RefSeq, PubMed]; Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2 (PubMed:19648922). May participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction. Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A. Promotes recruitment of RORC to the IL-17 promoter (By similarity). May be involved in the maintenance of peripheral cell tolerance by serving as a negative regulator of the immune response. May disable autoantibody responses and inhibit IFN-gamma secretion by CD4(+) T-cells (PubMed:23914190). May negatively regulate the size of thymic innate CD8(+) T-cells and the development of invariant natural killer T (iNKT) cells (PubMed:23225888). Can promote natural killer (NK) cell activation (PubMed:19648922)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; The Checkpoint Regulator SLAMF3 Preferentially Prevents Expansion of Auto-Reactive B Cells Generated by Graft-vs.-Host Disease. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q9ES29;Q9ES35;Q9ES36", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0032740 positive regulation of interleukin-17 production;GO:0006955 immune response;GO:0007155 cell adhesion;GO:0045087 innate immune response;GO:0042110 T cell activation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q01965-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O09010-1", "uniprot_id": [ { "id": "LFNG_MOUSE", "url": "https://www.uniprot.org/uniprot/O09010", "type": "external" } ], "mass": 41952.0, "length": 378, "protein_name": "Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe", "gene_name": "Lfng", "organism": "Mouse", "refseq_name": "beta-1,3-N-acetylglucosaminyltransferase lunatic fringe", "refseq_ac": [ { "id": "NP_032520", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032520", "type": "external" } ], "gene_names_uniprotkb": "Lfng", "gene_names_refseq": "Lfng", "protein_names_uniprotkb": "Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe; 2.4.1.222; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase", "protein_names_refseq": "O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; beta-1,3-N-acetylglucosaminyltransferase lunatic fringe; lunatic fringe", "tax_id": 10090, "disease": "spondylocostal dysostosis 3 (Disease Ontology:DOID:0112361)", "pathway": " (mmu:16848)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;10330372;10341080;10935626;11520458;12110168;12110169;12167404;16221665;16385447;26740625;28089369;34428180;39407201;9187150;9207795;9690473", "class_list": "glycogene;glycosyltransferase", "function": "Androgen blockage impairs proliferation and function of Sertoli cells via Wee1 and Lfng. Publication Status: Online-Only, [RefSeq, PubMed]; Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules (PubMed:10935626). Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1 (PubMed:16385447, PubMed:28089369). Decreases the binding of JAG1 to NOTCH2 but not that of DLL1 (By similarity). Essential mediator of somite segmentation and patterning. During somite boundary formation, it restricts Notch activity in the presomitic mesoderm to a boundary-forming territory in the posterior half of the prospective somite. In this region, Notch function activates a set of genes that are involved in boundary formation and in anterior-posterior somite identity (PubMed:10330372). Ectopically expressed in the thymus, Lfgn inhibits Notch signaling which results in inhibition of T-cell commitment and promotes B-cell development in lymphoid progenitors (PubMed:11520458). May play a role in boundary formation of the enamel knot (PubMed:12167404)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 17, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3U659;Q8K3F1;Q9DC10", "ec_number_list": [ { "id": "2.4.1.222", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.222", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0051446 positive regulation of meiotic cell cycle;GO:0045747 positive regulation of Notch signaling pathway;GO:0001756 somitogenesis;GO:0001541 ovarian follicle development;GO:0014807 regulation of somitogenesis", "synthesized_glycan_count": 19, "hit_score": 2.0, "record_id": "O09010-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1000000001000.101.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U1D0-1", "uniprot_id": [ { "id": "LINES_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U1D0", "type": "external" } ], "mass": 85642.0, "length": 764, "protein_name": "Protein Lines homolog 1", "gene_name": "Lins1", "organism": "Mouse", "refseq_name": "protein Lines homolog 1 isoform 2", "refseq_ac": [ { "id": "NP_001177930", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001177930", "type": "external" } ], "gene_names_uniprotkb": "Lins1; Lins2; Lins; Wins2", "gene_names_refseq": "2700083B01Rik; Lins1; Lins2; Lins; Wins2", "protein_names_uniprotkb": "Protein Lines homolog 1; Protein Lines homolog 2; Wnt-signaling molecule Lines homolog 1", "protein_names_refseq": "Wins2 protein with Drosophila Lin homologous domain; lines homolog 2; protein Lines homolog 1 isoform 2; protein Lines homolog 1; protein Lines homolog 2; protein with Drosophila Lines homologous domain; wnt-signaling molecule Lines homolog 1; wnt-signaling molecule Lines homolog 2", "tax_id": 10090, "disease": "autosomal recessive intellectual developmental disorder 27 (Disease Ontology:DOID:0081193)", "pathway": " (mmu:72635)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12119551;21183079;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TBL8;Q6PCP6;Q8K4P9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0050890 cognition", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3U1D0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UH68-1", "uniprot_id": [ { "id": "LIMC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UH68", "type": "external" } ], "mass": 118196.0, "length": 1057, "protein_name": "LIM and calponin homology domains-containing protein 1", "gene_name": "Limch1", "organism": "Mouse", "refseq_name": "LIM and calponin homology domains-containing protein 1 isoform 1", "refseq_ac": [ { "id": "NP_001001980", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001980", "type": "external" } ], "gene_names_uniprotkb": "Limch1; Kiaa1102", "gene_names_refseq": "3732412D22Rik; Limch1; mKIAA1102", "protein_names_uniprotkb": "LIM and calponin homology domains-containing protein 1", "protein_names_refseq": "LIM and calponin homology domains-containing protein 1 isoform 1; LIM and calponin homology domains-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:77569)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "16452087;21183079;21750661;22517741;22645316;30084848;30779550;32848054;34678516;35822049;36288343;36977593;39927985;40021952;40885482", "class_list": "", "function": "Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration., [UniProtKB, UniProtKB]; The role of Limch1 alternative splicing in skeletal muscle function. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 31, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q6DIC3;Q80TK1", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0046872 metal ion binding;GO:0032034 myosin II head/neck binding", "go_cellular_component": "GO:0015629 actin cytoskeleton;GO:0001725 stress fiber", "go_biological_process": "GO:0051893 regulation of focal adhesion assembly;GO:0060327 cytoplasmic actin-based contraction involved in cell motility;GO:0001934 positive regulation of protein phosphorylation;GO:0030336 negative regulation of cell migration;GO:0051496 positive regulation of stress fiber assembly", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q3UH68-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KL25-1", "uniprot_id": [ { "id": "LHPL5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q4KL25", "type": "external" } ], "mass": 24186.0, "length": 219, "protein_name": "LHFPL tetraspan subfamily member 5 protein", "gene_name": "Lhfpl5", "organism": "Mouse", "refseq_name": "LHFPL tetraspan subfamily member 5 protein", "refseq_ac": [ { "id": "NP_080847", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080847", "type": "external" } ], "gene_names_uniprotkb": "Lhfpl5; Tmhs", "gene_names_refseq": "9330179O15Rik; Lhfpl5; Tmhs; hscy", "protein_names_uniprotkb": "LHFPL tetraspan subfamily member 5 protein; Lipoma HMGIC fusion partner-like 5 protein; Tetraspan membrane protein of hair cell stereocilia", "protein_names_refseq": "LHFPL tetraspan subfamily member 5 protein; lipoma HMGIC fusion partner-like 5 protein; tetraspan membrane protein of hair cell stereocilia; tetraspan transmembrane protein, hair cell stereocilia", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 67 (Disease Ontology:DOID:0110518)", "pathway": " (mmu:328789)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "15905332;16459341;17876667;23217710;25467981;26964900;33509951;36191207;38194445", "class_list": "", "function": "Alternative Splicing of Three Genes Encoding Mechanotransduction-Complex Proteins in Auditory Hair Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Auxiliary subunit of the mechanotransducer (MET) non-specific cation channel complex located at the tips of the shorter stereocilia of cochlear hair cells and that mediates sensory transduction in the auditory system (PubMed:15905332, PubMed:23217710, PubMed:36191207). The MET complex is composed of two dimeric pore-forming ion-conducting transmembrane TMC (TMC1 or TMC2) subunits, and aided by several auxiliary proteins including LHFPL5, TMIE, CIB2/3 and TOMT, and the tip-link PCDH15 (PubMed:23217710, PubMed:36191207). Functionally couples PCDH15 to the transduction channel (PubMed:23217710)., [UniProtKB, PubMed, PubMed, PubMed]; Hurry-scurry (hscy)-2J, a mutation of Tmhs, causes abnormal splicing from a cryptic splice site within exon 2 that is predicted to produce a functionally null protein lacking 51 amino acids of the wild-type sequence., [RefSeq, PubMed]; LHFPL5 is a key element in force transmission from the tip link to the hair cell mechanotransducer channel., [RefSeq, PubMed]; TMHS is an integral component of the hair cell's mechanotransduction machinery that functionally couples PCDH15 to the transduction channel., [RefSeq, PubMed]; TMHS localizes to the apical membrane of inner ear hair cells during stereocilia formation suggesting a function in hair bundle morphogenesis; a missense mutation underlies deafness in hurry-scurry mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2KF30", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0032426 stereocilium tip;GO:0032421 stereocilium bundle", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0050910 detection of mechanical stimulus involved in sensory perception of sound;GO:0007605 sensory perception of sound;GO:0050974 detection of mechanical stimulus involved in sensory perception;GO:0060088 auditory receptor cell stereocilium organization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q4KL25-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64253-1", "uniprot_id": [ { "id": "LY6E_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64253", "type": "external" } ], "mass": 14392.0, "length": 136, "protein_name": "Lymphocyte antigen 6E", "gene_name": "Ly6e", "organism": "Mouse", "refseq_name": "lymphocyte antigen 6E precursor", "refseq_ac": [ { "id": "NP_001157508", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157508", "type": "external" } ], "gene_names_uniprotkb": "Ly6e; Ly67; Sca-2; Tsa-1", "gene_names_refseq": "Ly67; Ly6e; RIG-E; Sca-2; TSA-1; Tsa1", "protein_names_uniprotkb": "Lymphocyte antigen 6E; Ly-6E; Stem cell antigen 2; TSA-1; Thymic shared antigen 1", "protein_names_refseq": "lymphocyte antigen 6 complex, locus E; lymphocyte antigen 6E precursor; lymphocyte antigen 6E; stem cell antigen 2; thymic shared antigen 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:17069); (R-MMU-163125)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "11784869;1531995;21750661;26276394;28679758;29500366;2987354;30084848;3040423;32704094;7499840;8202484;8258699;8642345;8662090;9575182", "class_list": "", "function": "GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation (PubMed:8642345, PubMed:9575182). Regulates the T-cell receptor (TCR) signaling by interacting with component CD3Z/CD247 at the plasma membrane, leading to CD3Z/CD247 phosphorylation modulation (PubMed:9575182). Restricts the entry of murine coronavirus, mouse hepatitis virus, by interfering with spike protein-mediated membrane fusion (PubMed:32704094). Also plays an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA) (PubMed:28679758). Therefore, participates in the normal fusion of syncytiotrophoblast layer I (SynT-I) and in the proper morphogenesis of both fetal and maternal vasculatures within the placenta (PubMed:29500366). May also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4-containing nAChRs maximum response (PubMed:26276394)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q61128;Q99JA5", "ec_number_list": [], "go_molecular_function": "GO:0033130 acetylcholine receptor binding;GO:0030550 acetylcholine receptor inhibitor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse;GO:0098552 side of membrane", "go_biological_process": "GO:0048242 epinephrine secretion;GO:0001701 in utero embryonic development;GO:0095500 acetylcholine receptor signaling pathway;GO:0042415 norepinephrine metabolic process;GO:0030325 adrenal gland development", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q64253-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C129-1", "uniprot_id": [ { "id": "LCAP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C129", "type": "external" } ], "mass": 117304.0, "length": 1025, "protein_name": "Leucyl-cystinyl aminopeptidase", "gene_name": "Lnpep", "organism": "Mouse", "refseq_name": "leucyl-cystinyl aminopeptidase", "refseq_ac": [ { "id": "NP_766415", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766415", "type": "external" } ], "gene_names_uniprotkb": "Lnpep", "gene_names_refseq": "2010309L07Rik; 4732490P18Rik; CAP; IRAP; Lnpep; PLAP; gp160; vp165", "protein_names_uniprotkb": "Leucyl-cystinyl aminopeptidase; 3.4.11.3; Cystinyl aminopeptidase; OTase; Oxytocinase", "protein_names_refseq": "OTase; cystinyl aminopeptidase; leucyl-cystinyl aminopeptidase; oxytocinase", "tax_id": 10090, "disease": "leiomyoma (Disease Ontology:DOID:127); severe pre-eclampsia (Disease Ontology:DOID:13129); breast cancer (Disease Ontology:DOID:1612); renal cell carcinoma (Disease Ontology:DOID:4450); polyhydramnios (Disease Ontology:DOID:8488); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:240028); (R-MMU-1236977); (R-MMU-983168)", "pathway_count": 3, "publication_count": 23, "publication_id_list": "10.1101/2023.09.13.557529;12700100;16075062;19144319;19349973;21183079;25428506;25605945;26740625;30084848;30779550;30899004;31219806;32152506;33300544;33846534;34428180;35820727;36708814;36995926;37507081;37828378;39627609", "class_list": "", "function": "Control of IFN-I responses by the aminopeptidase IRAP in neonatal C57BL/6 alveolar macrophages during RSV infection., [RefSeq, PubMed]; Initial characterization of knockout mice in which IRAP/P-LAP was deleted revealed that GLUT4 protein levels were dramatically decreased in all fat and muscle tissues. Review article Publication Status: Online-Only, [RefSeq, PubMed]; Insulin-regulated aminopeptidase is required for water excretion in response to acute hypotonic stress., [RefSeq, PubMed]; Mast cell-mediated inflammation relies on insulin-regulated aminopeptidase controlling cytokine export from the Golgi., [RefSeq, PubMed]; Release of an N-terminal amino acid, cleave before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain (By similarity)., [UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 7, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 10, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 11, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 11, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 11, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 26, "disease_count": 6, "glyco_site_count": 19, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.4.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-", "type": "external" }, { "id": "3.4.11.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.14", "type": "external" }, { "id": "3.4.14.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.10", "type": "external" }, { "id": "3.4.11.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.3", "type": "external" }, { "id": "3.4.22.40", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.40", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004177 aminopeptidase activity;GO:0070006 metalloaminopeptidase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0043025 neuronal cell body;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006508 proteolysis;GO:0045777 positive regulation of blood pressure;GO:0048169 regulation of long-term neuronal synaptic plasticity;GO:0008217 regulation of blood pressure;GO:0043171 peptide catabolic process", "synthesized_glycan_count": 0, "hit_score": 6.2, "record_id": "Q8C129-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91ZP3-1", "uniprot_id": [ { "id": "LPIN1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91ZP3", "type": "external" } ], "mass": 102002.0, "length": 924, "protein_name": "Phosphatidate phosphatase LPIN1", "gene_name": "Lpin1", "organism": "Mouse", "refseq_name": "phosphatidate phosphatase LPIN1 isoform a", "refseq_ac": [ { "id": "NP_001123884", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123884", "type": "external" } ], "gene_names_uniprotkb": "Lpin1; Flde", "gene_names_refseq": "Lipin1; Lpin1; fld", "protein_names_uniprotkb": "Phosphatidate phosphatase LPIN1; 3.1.3.4; Fatty liver dystrophy protein; Lipin-1", "protein_names_refseq": "fatty liver dystrophy protein; phosphatidate phosphatase LPIN1 isoform a; phosphatidate phosphatase LPIN1", "tax_id": 10090, "disease": "myoglobinuria (Disease Ontology:DOID:0080108); morbid obesity (Disease Ontology:DOID:11981); lipid metabolism disorder (Disease Ontology:DOID:3146); end stage renal disease (Disease Ontology:DOID:783); lipodystrophy (Disease Ontology:DOID:811); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:14245); (R-MMU-1483191); (R-MMU-1483213); (R-MMU-4419969); (R-MMU-75109)", "pathway_count": 5, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;11138012;11792863;16049017;16950137;17105729;17158099;19717560;19753306;21183079;21397848;21750661;22134922;22299025;23426360;25428506;34428180;39014470", "class_list": "", "function": "Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis and therefore controls the metabolism of fatty acids at different levels (PubMed:17158099). Is involved in adipocyte differentiation (PubMed:16049017). Also acts as nuclear transcriptional coactivator for PPARGC1A/PPARA regulatory pathway to modulate lipid metabolism gene expression (PubMed:16950137)., [UniProtKB, PubMed, PubMed, PubMed]; Exploring lipin1 as a promising therapeutic target for the treatment of Duchenne muscular dystrophy. Publication Status: Online-Only, [RefSeq, PubMed]; Recruited at the mitochondrion outer membrane and is involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 3, "disease_count": 6, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9CQI2;Q9JLG6", "ec_number_list": [ { "id": "1.14.11.68", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.68", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.4", "type": "external" }, { "id": "3.6.1.75", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.75", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.106", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.106", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.68", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.68", "type": "external" } ], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0042826 histone deacetylase binding;GO:0042975 peroxisome proliferator activated receptor binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0008195 phosphatidate phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0046473 phosphatidic acid metabolic process;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006629 lipid metabolic process;GO:0006955 immune response", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q91ZP3-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99N69-1", "uniprot_id": [ { "id": "LPXN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99N69", "type": "external" } ], "mass": 43478.0, "length": 386, "protein_name": "Leupaxin", "gene_name": "Lpxn", "organism": "Mouse", "refseq_name": "leupaxin isoform 1", "refseq_ac": [ { "id": "NP_598913", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598913", "type": "external" } ], "gene_names_uniprotkb": "Lpxn", "gene_names_refseq": "4933402K05Rik; A530083L21Rik; LDPL; Lpxn", "protein_names_uniprotkb": "Leupaxin", "protein_names_refseq": "leupaxin isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:107321)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "12674328;15786712;16914530;17640867;17947660;18497331;19144319;19917054;21750661;31537712;32269569", "class_list": "", "function": "Association of the scaffold protein LPXN with Src adds further complexity to the organization of the podosomal signaling complex in osteoclasts., [RefSeq, PubMed]; Leupaxin Expression Is Dispensable for B Cell Immune Responses. Publication Status: Online-Only, [RefSeq, PubMed]; Leupaxin may be a critical nucleating component of the osteoclast podosomal signaling complex, [RefSeq, PubMed]; Leupaxin plays an inhibitory role in BCR signaling and B cell function., [RefSeq, PubMed]; The kindlin-3 not only activates and clusters integrins into podosomes but also regulates their lifetime by recruiting leupaxin, which controls PTP-PEST activity and thereby paxillin phosphorylation and downstream signaling., [RefSeq, PubMed]; Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0033628 regulation of cell adhesion mediated by integrin;GO:0006351 DNA-templated transcription;GO:0007162 negative regulation of cell adhesion;GO:0034446 substrate adhesion-dependent cell spreading;GO:0043542 endothelial cell migration", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q99N69-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CPU0-1", "uniprot_id": [ { "id": "LGUL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CPU0", "type": "external" } ], "mass": 20810.0, "length": 184, "protein_name": "Lactoylglutathione lyase", "gene_name": "Glo1", "organism": "Mouse", "refseq_name": "lactoylglutathione lyase", "refseq_ac": [ { "id": "NP_001107032", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107032", "type": "external" } ], "gene_names_uniprotkb": "Glo1", "gene_names_refseq": "0610009E22Rik; 1110008E19Rik; 2510049H23Rik; GLY1; Glo-1r; Glo-1s; Glo-1; Glo1-r; Glo1-s; Glo1; Qglo", "protein_names_uniprotkb": "Lactoylglutathione lyase; 4.4.1.5; Aldoketomutase; Glx I; Glyoxalase I; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase", "protein_names_refseq": "S-D-lactoylglutathione methylglyoxal lyase; aldoketomutase; glx I; glyoxalase 1 complex; glyoxalase 1 regulatory; glyoxalase 1 structural; glyoxalase I; ketone-aldehyde mutase; lactoylglutathione lyase; methylglyoxalase", "tax_id": 10090, "disease": "autistic disorder (Disease Ontology:DOID:12849); vascular disease (Disease Ontology:DOID:178); end stage renal disease (Disease Ontology:DOID:783); diabetic retinopathy (Disease Ontology:DOID:8947); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:109801); (R-MMU-70268)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "15858064;18695250;21750661;23806337;32966793;34428180;35620868;37419278;37507081;39927985", "class_list": "", "function": "Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione (PubMed:18695250). Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B (By similarity). Required for normal osteoclastogenesis (PubMed:18695250)., [UniProtKB, PubMed, UniProtKB]; Glyoxalase 1 knockdown induces age-related beta-cell dysfunction and glucose intolerance in mice., [RefSeq, PubMed]; Overexpressing glyoxalase 1 attenuates acute hyperglycemia-exacerbated neurological deficits of ischemic stroke in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q543L3;Q8R3T1", "ec_number_list": [ { "id": "4.4.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.5", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004462 lactoylglutathione lyase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione;GO:0006357 regulation of transcription by RNA polymerase II;GO:0043066 negative regulation of apoptotic process;GO:0009438 methylglyoxal metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9CPU0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60767-1", "uniprot_id": [ { "id": "LY75_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60767", "type": "external" } ], "mass": 197352.0, "length": 1723, "protein_name": "Lymphocyte antigen 75", "gene_name": "Ly75", "organism": "Mouse", "refseq_name": "lymphocyte antigen 75 precursor", "refseq_ac": [ { "id": "NP_038853", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038853", "type": "external" } ], "gene_names_uniprotkb": "Ly75; Cd205", "gene_names_refseq": "CD205; DEC-205; DEC205; Ly75", "protein_names_uniprotkb": "Lymphocyte antigen 75; DEC-205; Ly-75", "protein_names_refseq": "ly-75; lymphocyte antigen 75 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:17076)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;11465105;19349973;19656770;21183079;21750661;25428506;26495903;26740625;28011936;29187734;30779550;30899004;31219806;32152506;34428180;36210013;7553896;7753172", "class_list": "glycogene", "function": "Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment. Causes reduced proliferation of B lymphocytes (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 7, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 7, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 7, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 8, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 8, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 109, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 8, "disease_count": 0, "glyco_site_count": 16, "binding_glycan_count": 0, "secondary_ac_list": "B2RWW5;Q8C7T3;Q91XL8;Q9QUZ6", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006898 receptor-mediated endocytosis;GO:0006897 endocytosis", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "Q60767-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000011001.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JHQ5-1", "uniprot_id": [ { "id": "LZTL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JHQ5", "type": "external" } ], "mass": 34773.0, "length": 299, "protein_name": "Leucine zipper transcription factor-like protein 1", "gene_name": "Lztfl1", "organism": "Mouse", "refseq_name": "leucine zipper transcription factor-like protein 1", "refseq_ac": [ { "id": "NP_201579", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_201579", "type": "external" } ], "gene_names_uniprotkb": "Lztfl1", "gene_names_refseq": "5530402H04Rik; 6130400H19Rik; Lztfl1", "protein_names_uniprotkb": "Leucine zipper transcription factor-like protein 1", "protein_names_refseq": "leucine zipper transcription factor-like protein 1", "tax_id": 10090, "disease": "Bardet-Biedl syndrome 17 (Disease Ontology:DOID:0110139)", "pathway": " (mmu:93730); (R-MMU-5620922)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "11352561;20233871;21750661;22072986;22093827;30779550;31219806;32568387;34023333;34428180;38310669", "class_list": "", "function": "Anti-inflammation of LZTFL1 knockdown in OVA-induced asthmatic mice: Through ERK/GATA3 signaling pathway., [RefSeq, PubMed]; Leucine zipper transcription factor-like 1 (LZTFL1), an intraflagellar transporter protein 27 (IFT27) associated protein, is required for normal sperm function and male fertility., [RefSeq, PubMed]; Limited time window for retinal gene therapy in a preclinical model of ciliopathy., [RefSeq, PubMed]; Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BRX8;Q8CDS2", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005929 cilium;GO:0002177 manchette;GO:0035869 ciliary transition zone", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030317 flagellated sperm motility;GO:1903565 negative regulation of protein localization to cilium;GO:1903568 negative regulation of protein localization to ciliary membrane", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9JHQ5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TT79-1", "uniprot_id": [ { "id": "MCPH1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TT79", "type": "external" } ], "mass": 90373.0, "length": 822, "protein_name": "Microcephalin", "gene_name": "Mcph1", "organism": "Mouse", "refseq_name": "microcephalin isoform 3", "refseq_ac": [ { "id": "NP_775281", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775281", "type": "external" } ], "gene_names_uniprotkb": "Mcph1", "gene_names_refseq": "5430437K10Rik; BRIT1; D030046N04Rik; MCT; Mcph1; Tg(HLA-A2.1)1Enge", "protein_names_uniprotkb": "Microcephalin", "protein_names_refseq": "microcephalin isoform 3; microcephalin", "tax_id": 10090, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); primary autosomal recessive microcephaly 1 (Disease Ontology:DOID:0070285); autosomal recessive primary microcephaly (Disease Ontology:DOID:0070296); microcephaly (Disease Ontology:DOID:10907); endometrial cancer (Disease Ontology:DOID:1380); breast cancer (Disease Ontology:DOID:1612); renal carcinoma (Disease Ontology:DOID:4451)", "pathway": " (mmu:244329); (R-MMU-2299718)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "12046007;21183079;21750661;25428506;38632351;38731817", "class_list": "", "function": "Aging-induced MCPH1 translocation activates necroptosis and impairs hematopoietic stem cell function., [RefSeq, PubMed]; Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Microcephaly Gene Mcph1 Deficiency Induces p19ARF-Dependent Cell Cycle Arrest and Senescence. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BNI9;Q8C9I7", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005813 centrosome", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0000278 mitotic cell cycle;GO:0021987 cerebral cortex development;GO:0050727 regulation of inflammatory response;GO:0060348 bone development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q7TT79-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61083-1", "uniprot_id": [ { "id": "M3K2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61083", "type": "external" } ], "mass": 69574.0, "length": 619, "protein_name": "Mitogen-activated protein kinase kinase kinase 2", "gene_name": "Map3k2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Map3k2; Mekk2", "gene_names_refseq": "", "protein_names_uniprotkb": "Mitogen-activated protein kinase kinase kinase 2; 2.7.11.25; MAPK/ERK kinase kinase 2; MEK kinase 2; MEKK 2", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:26405)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10818102;12659851;12912994;17242355;21183079;21750661;34428180;8621389", "class_list": "", "function": "Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7. Plays a role in caveolae kiss-and-run dynamics (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0035556 intracellular signal transduction;GO:0000165 MAPK cascade;GO:0071260 cellular response to mechanical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q61083-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08648-1", "uniprot_id": [ { "id": "M3K4_MOUSE", "url": "https://www.uniprot.org/uniprot/O08648", "type": "external" } ], "mass": 179834.0, "length": 1597, "protein_name": "Mitogen-activated protein kinase kinase kinase 4", "gene_name": "Map3k4", "organism": "Mouse", "refseq_name": "mitogen-activated protein kinase kinase kinase 4 isoform 1", "refseq_ac": [ { "id": "NP_036078", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036078", "type": "external" } ], "gene_names_uniprotkb": "Map3k4; Mekk4", "gene_names_refseq": "D17Rp17e; D17Rp17; MAPKKK4; MEKK 4; MTK1; Map3k4; Mek4b; Mekk4; RP17; Rp17a; Tas; mKIAA0213", "protein_names_uniprotkb": "Mitogen-activated protein kinase kinase kinase 4; 2.7.11.25; MAPK/ERK kinase kinase 4; MEK kinase 4; MEKK 4", "protein_names_refseq": "MAPK/ERK kinase kinase 4; MEK kinase 4; T-associated sex reversal; mitogen-activated protein kinase kinase kinase 4 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:26407)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;15262978;16157600;17242355;21183079;21750661;27358404;30084848;33184917;33912929;34428180;35921893;9079650;9268631", "class_list": "", "function": "Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6., [UniProtKB, PubMed, PubMed]; LncRNA-MAP3K4 regulates vascular inflammation through the p38 MAPK signaling pathway and cis-modulation of MAP3K4., [RefSeq, PubMed]; MAP3K4 kinase activity dependent control of mouse gonadal sex determinationdagger., [RefSeq, PubMed]; MAP3K4 promotes fetal and placental growth by controlling the receptor tyrosine kinases IGF1R/IR and Akt signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O08649;O70124;Q6PDG6", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004709 MAP kinase kinase kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0060718 chorionic trophoblast cell differentiation;GO:0035556 intracellular signal transduction;GO:0000165 MAPK cascade;GO:0001890 placenta development;GO:1900745 positive regulation of p38MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "O08648-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97823-1", "uniprot_id": [ { "id": "LYPA1_MOUSE", "url": "https://www.uniprot.org/uniprot/P97823", "type": "external" } ], "mass": 24688.0, "length": 230, "protein_name": "Acyl-protein thioesterase 1", "gene_name": "Lypla1", "organism": "Mouse", "refseq_name": "acyl-protein thioesterase 1 isoform 1", "refseq_ac": [ { "id": "NP_032892", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032892", "type": "external" } ], "gene_names_uniprotkb": "Lypla1; Apt1; Pla1a", "gene_names_refseq": "APT-1; Gm39587; LPL-I; Lypla1; Pla1a", "protein_names_uniprotkb": "Acyl-protein thioesterase 1; 3.1.2.-; 3.1.2.22; APT-1; LPL-I; LysoPLA I; Lysophospholipase 1; Lysophospholipase I; Palmitoyl-protein hydrolase", "protein_names_refseq": "acyl-protein thioesterase 1 isoform 1; acyl-protein thioesterase 1; lysoPLA I; lysophopholipase 1; lysophospholipase I; palmitoyl-protein hydrolase; phospholipase 1a", "tax_id": 10090, "disease": "", "pathway": " (mmu:18777); (R-MMU-203615); (R-MMU-9648002)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "20173027;21750661;23576753;30084848;31219806;31599954;31616917;34428180;36210013;37453647;39927985;9139730;9268342", "class_list": "", "function": "Acts as an acyl-protein thioesterase (By similarity). Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS (By similarity). Acts as a palmitoyl thioesterase that catalyzes depalmitoylation of proteins, such as ADRB2, KCNMA1 and SQSTM1 (By similarity). Acts as a negative regulator of autophagy by mediating palmitoylation of SQSTM1, decreasing affinity between SQSTM1 and ATG8 proteins and recruitment of ubiquitinated cargo proteins to autophagosomes (By similarity). Acts as a lysophospholipase and hydrolyzes lysophosphatidylcholine (lyso-PC) (By similarity). Also hydrolyzes lysophosphatidylethanolamine (lyso-PE), lysophosphatidylinositol (lyso-PI) and lysophosphatidylserine (lyso-PS) (PubMed:9139730). Has much higher thioesterase activity than lysophospholipase activity (By similarity). Contributes to the production of lysophosphatidic acid (LPA) during blood coagulation by recognizing and cleaving plasma phospholipids to generate lysophospholipids which in turn act as substrates for ENPP2 to produce LPA (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Acts as an acyl-protein thioesterase. Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Acts as a palmitoyl thioesterase that catalyzes depalmitoylation of proteins, such as ADRB2, KCNMA1 and SQSTM1. Acts as a negative regulator of autophagy by mediating palmitoylation of SQSTM1, decreasing affinity between SQSTM1 and ATG8 proteins and recruitment of ubiquitinated cargo proteins to autophagosomes. Acts as a lysophospholipase and hydrolyzes lysophosphatidylcholine (lyso-PC). Also hydrolyzes lysophosphatidylethanolamine (lyso-PE), lysophosphatidylinositol (lyso-PI) and lysophosphatidylserine (lyso-PS). Has much higher thioesterase activity than lysophospholipase activity. Contributes to the production of lysophosphatidic acid (LPA) during blood coagulation by recognizing and cleaving plasma phospholipids to generate lysophospholipids which in turn act as substrates for ENPP2 to produce LPA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJZ0;Q7TPX1;Q8BWM6", "ec_number_list": [ { "id": "3.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.1", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "3.1.1.93", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.93", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0016298 lipase activity;GO:0004620 phospholipase activity;GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0008474 palmitoyl-(protein) hydrolase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0015908 fatty acid transport;GO:0042997 negative regulation of Golgi to plasma membrane protein transport;GO:0035973 aggrephagy;GO:0002084 protein depalmitoylation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P97823-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UGS4-1", "uniprot_id": [ { "id": "MCRI1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UGS4", "type": "external" } ], "mass": 11101.0, "length": 97, "protein_name": "Mapk-regulated corepressor-interacting protein 1", "gene_name": "Mcrip1", "organism": "Mouse", "refseq_name": "mapk-regulated corepressor-interacting protein 1", "refseq_ac": [ { "id": "NP_001028403", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028403", "type": "external" } ], "gene_names_uniprotkb": "Mcrip1; Fam195b", "gene_names_refseq": "Fam195b; Mcrip1", "protein_names_uniprotkb": "Mapk-regulated corepressor-interacting protein 1; Protein FAM195B", "protein_names_refseq": "family with sequence similarity 195, member B; mapk-regulated corepressor-interacting protein 1; protein FAM195B", "tax_id": 10090, "disease": "", "pathway": " (mmu:192173)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "17242355;17947660;19144319;21183079;25728771;30084848;31240265;31599954;34428180", "class_list": "", "function": "MCRIP1 interferes with interactions of CtBP with the lung-enriched transcriptional repressors, Foxp1 and Foxp2, thereby preventing the recruitment of the CtBP co-repressor complex to the SP-B and SP-C promoters and maintaining them in an active chromatin state. Homozygous deficiency of Mcrip1 in mice causes fatal respiratory distress due to abnormal transcriptional repression of surfactant proteins. Publication Status: Online-Only, [RefSeq, PubMed]; The phosphorylation status of MCRIP1 functions as a molecular switch to regulate epithelial-mesenchymal transition. Unphosphorylated MCRIP1 binds to and inhibits the transcriptional corepressor CTBP(s). When phosphorylated by MAPK/ERK, MCRIP1 releases CTBP(s) resulting in transcriptional silencing of the E-cadherin gene and induction of epithelial-mesenchymal transition., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8QZS4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0010717 regulation of epithelial to mesenchymal transition;GO:0045814 negative regulation of gene expression, epigenetic;GO:0010467 gene expression", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q3UGS4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CR62-1", "uniprot_id": [ { "id": "M2OM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CR62", "type": "external" } ], "mass": 34155.0, "length": 314, "protein_name": "Mitochondrial 2-oxoglutarate/malate carrier protein", "gene_name": "Slc25a11", "organism": "Mouse", "refseq_name": "mitochondrial 2-oxoglutarate/malate carrier protein", "refseq_ac": [ { "id": "NP_077173", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077173", "type": "external" } ], "gene_names_uniprotkb": "Slc25a11; Ogc", "gene_names_refseq": "2310022P18Rik; 2oxoc; Slc25a11", "protein_names_uniprotkb": "Mitochondrial 2-oxoglutarate/malate carrier protein; Alpha-oxoglutarate carrier; OGCP; SLC25A11; Solute carrier family 25 member 11", "protein_names_refseq": "OGCP; alpha-oxoglutarate carrier; mitochondrial 2-oxoglutarate/malate carrier protein; solute carrier family 25 member 11", "tax_id": 10090, "disease": "pheochromocytoma/paraganglioma syndrome 6 (Disease Ontology:DOID:0061221)", "pathway": " (mmu:67863); (R-MMU-428643); (R-MMU-9856872)", "pathway_count": 3, "publication_count": 20, "publication_id_list": "18034455;21448454;21750661;23576753;23806337;25428506;25605945;26740625;29187734;30084848;30686754;31219806;33300544;34428180;36210013;36288343;37453647;37507081;38577966;39927985", "class_list": "", "function": "Cancer cells critically depended on the oxoglutarate carrier SLC25A11 for transporting NADH from cytosol to mitochondria as a malate form for the purpose of ATP production, [RefSeq, PubMed]; Catalyzes the transport of 2-oxoglutarate (alpha-oxoglutarate) across the inner mitochondrial membrane in an electroneutral exchange for malate (By similarity). Can also exchange 2-oxoglutarate for other dicarboxylic acids such as malonate, succinate, maleate and oxaloacetate, although with lower affinity (By similarity). Substrate exchange across the membrane occurs consecutively with one substrate being transported first, then dissociating from the substrate binding site before the second substrate binds for transport in the opposite direction (By similarity). Does not transport glutathione (By similarity). In addition can facilitate proton transport in the presence of protonophores such as long-chain fatty acids, contributing to mitochondrial uncoupling and regulation of mitochondrial energetic efficiency (PubMed:38577966). Contributes to several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, gluconeogenesis from lactate, and nitrogen metabolism (By similarity). Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae (By similarity). Involved in the regulation of apoptosis (PubMed:21448454)., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015139 alpha-ketoglutarate transmembrane transporter activity;GO:0022857 transmembrane transporter activity;GO:0015367 oxoglutarate:malate antiporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006094 gluconeogenesis;GO:0043490 malate-aspartate shuttle", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q9CR62-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61084-1", "uniprot_id": [ { "id": "M3K3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61084", "type": "external" } ], "mass": 70776.0, "length": 626, "protein_name": "Mitogen-activated protein kinase kinase kinase 3", "gene_name": "Map3k3", "organism": "Mouse", "refseq_name": "mitogen-activated protein kinase kinase kinase 3", "refseq_ac": [ { "id": "NP_036077", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036077", "type": "external" } ], "gene_names_uniprotkb": "Map3k3; Mekk3", "gene_names_refseq": "MAPKKK3; Map3k3; Mekk3; mKIAA4031", "protein_names_uniprotkb": "Mitogen-activated protein kinase kinase kinase 3; 2.7.11.25; MAPK/ERK kinase kinase 3; MEK kinase 3; MEKK 3", "protein_names_refseq": "MAPK/ERK kinase kinase 3; MEK kinase 3; MEKK 3; mitogen-activated protein kinase kinase kinase 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:26406); (R-MMU-9020702)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10671200;12391307;14634666;17242355;21183079;33812250;36719480;36995941;8621389", "class_list": "", "function": "Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators., [UniProtKB, PubMed]; Endothelial hyperactivation of mutant MAP3K3 induces cerebral cavernous malformation enhanced by PIK3CA GOF mutation., [RefSeq, PubMed]; MEKK3 activates IRF7 to trigger a potent type I interferon induction in response to TLR7/9 signaling., [RefSeq, PubMed]; Somatic variants of MAP3K3 are sufficient to cause cerebral and spinal cord cavernous malformations., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004709 MAP kinase kinase kinase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0000165 MAPK cascade;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0046777 protein autophosphorylation;GO:0001568 blood vessel development", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q61084-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91WK0-1", "uniprot_id": [ { "id": "LRRF2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91WK0", "type": "external" } ], "mass": 47148.0, "length": 415, "protein_name": "Leucine-rich repeat flightless-interacting protein 2", "gene_name": "Lrrfip2", "organism": "Mouse", "refseq_name": "leucine-rich repeat flightless-interacting protein 2 isoform 1", "refseq_ac": [ { "id": "NP_001158310", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158310", "type": "external" } ], "gene_names_uniprotkb": "Lrrfip2", "gene_names_refseq": "5133400F20Rik; Lrrfip2", "protein_names_uniprotkb": "Leucine-rich repeat flightless-interacting protein 2; LRR FLII-interacting protein 2", "protein_names_refseq": "LRR FLII-interacting protein 2; leucine-rich repeat flightless-interacting protein 2 isoform 1; leucine-rich repeat flightless-interacting protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:71268)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "17242355;18630941;19144319;21183079;21220426;21750661;23942110;25428506;30084848;30779550;34428180;34887587", "class_list": "", "function": "LRRFIP2 inhibits NLRP3 inflammasome activation by recruiting the caspase-1 inhibitor Flightless-I, thus outlining a new mechanism for negative regulation of NLRP3 inflammasome., [RefSeq, PubMed]; May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding (By similarity)., [UniProtKB]; Unambiguous characterization of site-specific phosphorylation of leucine-rich repeat Fli-I-interacting protein 2 (LRRFIP2) in Toll-like receptor 4 (TLR4)-mediated signaling., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BVD1;Q9CU89", "ec_number_list": [], "go_molecular_function": "GO:0030275 LRR domain binding", "go_cellular_component": "", "go_biological_process": "GO:0035660 MyD88-dependent toll-like receptor 4 signaling pathway;GO:0006355 regulation of DNA-templated transcription;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0016055 Wnt signaling pathway;GO:0032760 positive regulation of tumor necrosis factor production", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q91WK0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99PI5-1", "uniprot_id": [ { "id": "LPIN2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99PI5", "type": "external" } ], "mass": 99613.0, "length": 893, "protein_name": "Phosphatidate phosphatase LPIN2", "gene_name": "Lpin2", "organism": "Mouse", "refseq_name": "phosphatidate phosphatase LPIN2 isoform 2", "refseq_ac": [ { "id": "NP_075020", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075020", "type": "external" } ], "gene_names_uniprotkb": "Lpin2", "gene_names_refseq": "2610511G02Rik; Lpin2", "protein_names_uniprotkb": "Phosphatidate phosphatase LPIN2; 3.1.3.4; Lipin-2", "protein_names_refseq": "phosphatidate phosphatase LPIN2 isoform 2; phosphatidate phosphatase LPIN2", "tax_id": 10090, "disease": "Majeed syndrome (Disease Ontology:DOID:0061224); myoglobinuria (Disease Ontology:DOID:0080108); lipid metabolism disorder (Disease Ontology:DOID:3146); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:64898); (R-MMU-1483191); (R-MMU-1483213); (R-MMU-4419969); (R-MMU-75109)", "pathway_count": 5, "publication_count": 12, "publication_id_list": "11138012;17158099;17242355;18694939;19136718;19717560;21183079;21750661;30507612;32008742;33809261;37001383", "class_list": "", "function": "A conserved serine residue is required for the phosphatidate phosphatase activity but not the transcriptional coactivator functions of lipin-1 and lipin-2., [RefSeq, PubMed]; Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the endoplasmic reticulum membrane (PubMed:17158099). Plays important roles in controlling the metabolism of fatty acids at different levels. Also acts as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism., [UniProtKB, PubMed, PubMed, PubMed]; Deficiency of Lipin2 Results in Enhanced NF-kappaB Signaling and Osteoclast Formation in RAW-D Murine Macrophages. Publication Status: Online-Only, [RefSeq, PubMed]; Distinct and non-redundant functions of lipin 1 and 2 regulate lipid production during the cell cycle and adipocyte differentiation, [RefSeq, PubMed]; Lipin 2 plays an important role as a hepatic PAP-1 enzyme., [RefSeq, PubMed]; Lipin-2 degradation elicits a proinflammatory gene signature in macrophages., [RefSeq, PubMed]; Lipin-2 exhibits phosphatidate phosphatase type-1 (PAP1) activity, which has a key role in glycerolipid synthesis., [RefSeq, PubMed]; Lipin2 ameliorates diabetic encephalopathy via suppressing JNK/ERK-mediated NLRP3 inflammasome overactivation., [RefSeq, PubMed]; These data implicate lipin 2/3 as a control point for enterocyte phospholipid homeostasis and chylomicron biogenesis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C357;Q8C7I8;Q8CC85;Q8CHR7", "ec_number_list": [ { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.4", "type": "external" }, { "id": "3.6.1.75", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.75", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.106", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.106", "type": "external" } ], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008195 phosphatidate phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006629 lipid metabolic process;GO:0009062 fatty acid catabolic process;GO:0032869 cellular response to insulin stimulus;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q99PI5-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97457-1", "uniprot_id": [ { "id": "MYL11_MOUSE", "url": "https://www.uniprot.org/uniprot/P97457", "type": "external" } ], "mass": 18955.0, "length": 169, "protein_name": "Myosin regulatory light chain 11", "gene_name": "Myl11; Mylpf", "organism": "Mouse", "refseq_name": "myosin regulatory light chain 11 isoform 1", "refseq_ac": [ { "id": "NP_058034", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058034", "type": "external" } ], "gene_names_uniprotkb": "Myl11; Mylpf; Mylpf", "gene_names_refseq": "2410014J02Rik; MLC-2; Mlc2; Myl11; Mylpf", "protein_names_uniprotkb": "Myosin regulatory light chain 11; Fast skeletal myosin light chain 2; MLC2F; Myosin light chain 11; Myosin regulatory light chain 2, skeletal muscle isoform", "protein_names_refseq": "MLC2F; fast skeletal myosin light chain 2; myosin light chain 11; myosin light chain 2; myosin regulatory light chain 11 isoform 1; myosin regulatory light chain 11", "tax_id": 10090, "disease": "hypertrophic cardiomyopathy 10 (Disease Ontology:DOID:0110316); distal arthrogryposis type 1A (Disease Ontology:DOID:0111597); distal arthrogryposis type 1C (Disease Ontology:DOID:0112190)", "pathway": " (mmu:17907); (R-MMU-445355)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "17242355;17356007;21183079;21750661;30084848;34428180;36210013;37453647;39927985;8777429", "class_list": "", "function": "Myosin regulatory subunit that plays an essential role to maintain muscle integrity during early development (PubMed:17356007). Plays a role in regulation of muscle contraction (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0008307 structural constituent of muscle", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016459 myosin complex", "go_biological_process": "GO:0006936 muscle contraction;GO:0007519 skeletal muscle tissue development", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P97457-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K4B0-1", "uniprot_id": [ { "id": "MTA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K4B0", "type": "external" } ], "mass": 80798.0, "length": 715, "protein_name": "Metastasis-associated protein MTA1", "gene_name": "Mta1", "organism": "Mouse", "refseq_name": "metastasis-associated protein MTA1 isoform 4", "refseq_ac": [ { "id": "NP_001351550", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001351550", "type": "external" } ], "gene_names_uniprotkb": "Mta1", "gene_names_refseq": "Mta1", "protein_names_uniprotkb": "Metastasis-associated protein MTA1", "protein_names_refseq": "metastasis-associated protein MTA1 isoform 4; metastasis-associated protein MTA1", "tax_id": 10090, "disease": "", "pathway": " (mmu:116870); (R-MMU-3214815); (R-MMU-3232118); (R-MMU-73762); (R-MMU-8943724); (R-MMU-9937850); (R-MMU-9940951)", "pathway_count": 7, "publication_count": 24, "publication_id_list": "11483358;12370427;15077195;16617102;17242355;17666527;17671180;19805145;19837670;20071335;20519513;20682799;21183079;21750661;21965678;24089055;24970816;27806305;28982712;30228260;31219806;34180153;34428180;34779499", "class_list": "", "function": "MTA1, a metastasisassociated protein, in endothelial cells is an essential molecule for angiogenesis., [RefSeq, PubMed]; Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator (PubMed:20071335, PubMed:20682799). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (By similarity). In the NuRD complex, regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA (PubMed:17671180). In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A (PubMed:20071335, PubMed:21965678). Acts as a transcriptional coactivator of BCAS3, PAX5 and SUMO2, independent of the NuRD complex (PubMed:17671180, PubMed:21965678). Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3 (PubMed:20682799). Regulates p53-dependent and -independent DNA repair processes following genotoxic stress (PubMed:19805145, PubMed:20071335). Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair (PubMed:19805145, PubMed:19837670). Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles (PubMed:24089055). Positively regulates the CLOCK-BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1 (PubMed:24089055). Regulates deacetylation of BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression (PubMed:24089055). With Tfcp2l1, promotes establishment and maintenance of pluripotency in embryonic stem cells (ESCs) and inhibits endoderm differentiation (PubMed:28982712)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80UI1;Q8K4D4;Q924K9", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q8K4B0-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35379-1", "uniprot_id": [ { "id": "MRP1_MOUSE", "url": "https://www.uniprot.org/uniprot/O35379", "type": "external" } ], "mass": 171185.0, "length": 1528, "protein_name": "Multidrug resistance-associated protein 1", "gene_name": "Abcc1", "organism": "Mouse", "refseq_name": "multidrug resistance-associated protein 1 isoform 1", "refseq_ac": [ { "id": "NP_032602", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032602", "type": "external" } ], "gene_names_uniprotkb": "Abcc1; Abcc1a; Abcc1b; Mdrap; Mrp", "gene_names_refseq": "Abcc1a; Abcc1b; Abcc1; MRP; Mdrap; Mrp1", "protein_names_uniprotkb": "Multidrug resistance-associated protein 1; 7.6.2.2; 7.6.2.3; ATP-binding cassette sub-family C member 1; Glutathione-S-conjugate-translocating ATPase ABCC1; LTC4 transporter; Leukotriene C(4) transporter", "protein_names_refseq": "ATP-binding cassette, sub-family C (CFTR/MRP), member 1a; ATP-binding cassette, sub-family C (CFTR/MRP), member 1b; LTC4 transporter; glutathione-S-conjugate-translocating ATPase ABCC1; leukotriene C(4) transporter; multidrug resistance-associated protein 1 isoform 1; multidrug resistance-associated protein 1; multiple drug resistance-associated protein", "tax_id": 10090, "disease": "autosomal dominant nonsyndromic deafness 77 (Disease Ontology:DOID:0112168); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083)", "pathway": " (mmu:17250); (R-MMU-1660661); (R-MMU-189483); (R-MMU-2142691); (R-MMU-382556); (R-MMU-9707564); (R-MMU-9753281); (R-MMU-9758890)", "pathway_count": 8, "publication_count": 20, "publication_id_list": "19144319;21183079;21750661;23806337;25428506;25605945;26495903;31219806;34088745;34428180;36070769;36210013;38829241;38870779;38926988;38951883;41018975;8649356;9281595;9359705", "class_list": "", "function": "ABCC1 deficiency potentiated noise-induced hearing loss in mice by impairing cochlear antioxidant capacity., [RefSeq, PubMed]; ATP-binding cassette family C member 1 constrains metabolic responses to high-fat diet in male mice. Publication Status: Online-Only, [RefSeq, PubMed]; Low-intensity noise exposure takes an essential part in the mechanism of late-onset hereditary hearing loss caused by Abcc1 mutation., [RefSeq, PubMed]; Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs by decreasing accumulation of drugs in cells, and by mediating ATP- and GSH-dependent drug export (PubMed:9281595, PubMed:9359705). Hydrolyzes ATP with low efficiency. Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation (By similarity). Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthesizing cells (PubMed:9359705). Mediates ATP-dependent, GSH-independent cyclic GMP-AMP (cGAMP) export (PubMed:36070769). Thus, by limiting intracellular cGAMP concentrations negatively regulates the cGAS-STING pathway (PubMed:36070769). Exports S-geranylgeranyl-glutathione (GGG) in lymphoid cells and stromal compartments of lymphoid organs. ABCC1 (via extracellular transport) with GGT5 (via GGG catabolism) establish GGG gradients within lymphoid tissues to position P2RY8-positive lymphocytes at germinal centers in lymphoid follicles and restrict their chemotactic transmigration from blood vessels to the bone marrow parenchyma (PubMed:34088745). Mediates basolateral export of GSH-conjugated R- and S-prostaglandin A2 diastereomers in polarized epithelial cells (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein plays an essential role in the defense against toxic compounds and serves as the major high-affinity transporter of leukotriene C4. The encoded protein may also play an essential role in steroid hormone homeostasis as a transporter for steroid hormones and their metabolites. [provided by RefSeq, Nov 2011]., [RefSeq]; [Study on Down-regulation of Interleukin-1beta Secretion by Inhibiting ABCC1/MRP1 Transporter]., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" } ], "go_molecular_function": "GO:0042910 xenobiotic transmembrane transporter activity;GO:0005324 long-chain fatty acid transmembrane transporter activity;GO:0005524 ATP binding;GO:0034040 ATPase-coupled lipid transmembrane transporter activity;GO:0008559 ABC-type xenobiotic transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0030054 cell junction;GO:0016324 apical plasma membrane;GO:0016328 lateral plasma membrane", "go_biological_process": "GO:0002432 granuloma formation;GO:0048708 astrocyte differentiation;GO:1903409 reactive oxygen species biosynthetic process;GO:0006954 inflammatory response;GO:0006955 immune response", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "O35379-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43247-1", "uniprot_id": [ { "id": "MSH2_MOUSE", "url": "https://www.uniprot.org/uniprot/P43247", "type": "external" } ], "mass": 104151.0, "length": 935, "protein_name": "DNA mismatch repair protein Msh2", "gene_name": "Msh2", "organism": "Mouse", "refseq_name": "DNA mismatch repair protein Msh2", "refseq_ac": [ { "id": "NP_032654", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032654", "type": "external" } ], "gene_names_uniprotkb": "Msh2", "gene_names_refseq": "Msh2", "protein_names_uniprotkb": "DNA mismatch repair protein Msh2; MutS protein homolog 2", "protein_names_refseq": "DNA mismatch repair protein Msh2; mutS protein homolog 2", "tax_id": 10090, "disease": "Muir-Torre syndrome (Disease Ontology:DOID:0050465); colitis (Disease Ontology:DOID:0060180); hereditary nonpolyposis colorectal cancer type 8 (Disease Ontology:DOID:0070270); Lynch syndrome 1 (Disease Ontology:DOID:0070271); mismatch repair cancer syndrome (Disease Ontology:DOID:0112182); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); lung cancer (Disease Ontology:DOID:1324); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); colon cancer (Disease Ontology:DOID:219); transitional cell carcinoma (Disease Ontology:DOID:2671); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); osteosarcoma (Disease Ontology:DOID:3347); breast carcinoma (Disease Ontology:DOID:3459); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); Lynch syndrome (Disease Ontology:DOID:3883); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); renal cell carcinoma (Disease Ontology:DOID:4450); primary ovarian insufficiency (Disease Ontology:DOID:5426); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:17685); (R-MMU-5358565); (R-MMU-5358606)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "21750661;21952136;22645316;23806337;25153642;25428506;25428507;25605945;30084848;30779550;34428180;35820727;37828378;39627609;7838728", "class_list": "", "function": "Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. Recruits DNA helicase MCM9 to chromatin which unwinds the mismatch containing DNA strand. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. In melanocytes may modulate both UV-B-induced cell cycle regulation and apoptosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 23, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0032357 oxidized purine DNA binding;GO:0032142 single guanine insertion binding;GO:0032143 single thymine insertion binding;GO:0032181 dinucleotide repeat insertion binding;GO:0000287 magnesium ion binding", "go_cellular_component": "GO:0032301 MutSalpha complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005694 chromosome;GO:0032302 MutSbeta complex", "go_biological_process": "GO:0006312 mitotic recombination;GO:0001701 in utero embryonic development;GO:0006281 DNA repair;GO:0043524 negative regulation of neuron apoptotic process;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P43247-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2C4-1", "uniprot_id": [ { "id": "MTMR1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z2C4", "type": "external" } ], "mass": 75313.0, "length": 669, "protein_name": "Phosphatidylinositol-3-phosphate phosphatase MTMR1", "gene_name": "Mtmr1", "organism": "Mouse", "refseq_name": "phosphatidylinositol-3-phosphate phosphatase MTMR1 isoform D", "refseq_ac": [ { "id": "NP_001300631", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001300631", "type": "external" } ], "gene_names_uniprotkb": "Mtmr1", "gene_names_refseq": "Mtmr1", "protein_names_uniprotkb": "Phosphatidylinositol-3-phosphate phosphatase MTMR1; 3.1.3.-; 3.1.3.95; Myotubularin-related protein 1; Phosphatidylinositol-3,5-bisphosphate 3-phosphatase; Phosphatidylinositol-3-phosphate phosphatase", "protein_names_refseq": "phosphatidylinositol-3,5-bisphosphate 3-phosphatase; phosphatidylinositol-3-phosphate phosphatase MTMR1 isoform D; phosphatidylinositol-3-phosphate phosphatase MTMR1; phosphatidylinositol-3-phosphate phosphatase", "tax_id": 10090, "disease": "Charcot-Marie-Tooth disease type 4B1 (Disease Ontology:DOID:0110191); centronuclear myopathy X-linked (Disease Ontology:DOID:0111225); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); myopathy (Disease Ontology:DOID:423)", "pathway": " (mmu:53332); (R-MMU-1660499); (R-MMU-9035034)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "12217958;20173027;21183079;21750661;22645316;25428506;25605945;27802388;30084848;30779550;32848054;34428180;40021952;40885482;9736772", "class_list": "", "function": "Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate, generating phosphatidylinositol (PubMed:12217958). Could also dephosphorylate phosphatidylinositol 3,5-bisphosphate to produce phosphatidylinositol 5-phosphate (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.95", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.95", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "1.16.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.1.-", "type": "external" }, { "id": "3.1.3.64", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.64", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity;GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0060304 regulation of phosphatidylinositol dephosphorylation;GO:0031648 protein destabilization;GO:0046856 phosphatidylinositol dephosphorylation;GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9Z2C4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70374-1", "uniprot_id": [ { "id": "MTG8R_MOUSE", "url": "https://www.uniprot.org/uniprot/O70374", "type": "external" } ], "mass": 65904.0, "length": 594, "protein_name": "Protein CBFA2T2", "gene_name": "Cbfa2t2", "organism": "Mouse", "refseq_name": "protein CBFA2T2 isoform 2", "refseq_ac": [ { "id": "NP_033953", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033953", "type": "external" } ], "gene_names_uniprotkb": "Cbfa2t2; Cbfa2t2h; Mtgr1", "gene_names_refseq": "A430091M07; C330013D05Rik; Cbfa2t2h; Cbfa2t2; MTGR1", "protein_names_uniprotkb": "Protein CBFA2T2; MTG8-like protein; MTG8-related protein 1", "protein_names_refseq": "CBFA2T2 identified gene homolog; MTG8-like protein; MTG8-related protein 1; core-binding factor, runt domain, alpha subunit 2, translocated to, 2 homolog; protein CBFA2T2 isoform 2; protein CBFA2T2", "tax_id": 10090, "disease": "", "pathway": " (mmu:12396)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "16227606;18039847;19618476;19799863;21303973;21750661;25398765;25428506;26523391;27281218;30084848;31219806;32703401;34428180;9790752", "class_list": "", "function": "CBFA2T2 promotes adipogenic differentiation of mesenchymal stem cells by regulating CEBPA., [RefSeq, PubMed]; Loss of Mtgr1 impairs the maturation of secretory cells in the small intestine., [RefSeq, PubMed]; Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Via association with PRDM14 is involved in regulation of embryonic stem cell (ESC) pluripotency. Involved in primordial germ cell (PCG) formation (PubMed:27281218). Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization-dependent mannerCan repress the expression of MMP7 in a ZBTB33-dependent manner (By similarity). Through heteromerization with CBFA2T3/MTG16 may be involved in regulation of the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (PubMed:19799863). Required for the maintenance of the secretory cell lineage in the small intestine (PubMed:16227606). Can inhibit Notch signaling probably by association with RBPJ and may be involved in GFI1-mediated Paneth cell differentiation (PubMed:25398765)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RRH8;Q30BK8;Q6P288", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0010976 positive regulation of neuron projection development;GO:0030855 epithelial cell differentiation;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "O70374-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4QQM5-1", "uniprot_id": [ { "id": "MIGA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q4QQM5", "type": "external" } ], "mass": 67536.0, "length": 600, "protein_name": "Mitoguardin 1", "gene_name": "Miga1", "organism": "Mouse", "refseq_name": "mitoguardin 1 isoform 2", "refseq_ac": [ { "id": "NP_001155847", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155847", "type": "external" } ], "gene_names_uniprotkb": "Miga1; Fam73a", "gene_names_refseq": "A930038D06; C030011O14Rik; Fam73a; Miga1; Mita1", "protein_names_uniprotkb": "Mitoguardin 1; Protein FAM73A", "protein_names_refseq": "family with sequence similarity 73, member A; mitoguardin 1 isoform 2; protein FAM73A", "tax_id": 10090, "disease": "", "pathway": " (mmu:215708); (R-MMU-1483166)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21183079;21750661;26711011;26716412;28938432", "class_list": "", "function": "Data indicate that mitoguardin (Miga) knoskout Miga1/2-/- females show greatly reduced quality of oocytes and early embryos and are subfertile., [RefSeq, PubMed]; Propose that MIGA1/2 proteins promote mitochondrial fusion by regulating mitochondrial phospholipid metabolism via MitoPLD., [RefSeq, PubMed]; Regulator of mitochondrial fusion (PubMed:26711011). Acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD (By similarity)., [UniProtKB, UniProtKB, PubMed]; The ovarian phenotypes of these mice suggested that MIGA1/2 proteins play an important role in ovulation and ovarian steroidogenesis. In vivo and in vitro analyses of Miga1/2-knockout granulosa cells showed severe defects in luteinization and steroidogenesis and disordered mitochondrial morphology and function in response to gonadotropins., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BR91;Q8C3S6;Q8C8P4", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0008053 mitochondrial fusion", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q4QQM5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61909-1", "uniprot_id": [ { "id": "MTG8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61909", "type": "external" } ], "mass": 64338.0, "length": 577, "protein_name": "Protein CBFA2T1", "gene_name": "Runx1t1", "organism": "Mouse", "refseq_name": "protein CBFA2T1 isoform 3", "refseq_ac": [ { "id": "NP_033952", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033952", "type": "external" } ], "gene_names_uniprotkb": "Runx1t1; Cbfa2t1h; Cbfa2t1; Mtg8", "gene_names_refseq": "Cbfa2t1h; ETO; MTG8; Runx1t1", "protein_names_uniprotkb": "Protein CBFA2T1; Protein MTG8", "protein_names_refseq": "CBFA2T1 identified gene homolog; acute myelogenous leukemia 1 translocation 1 protein; protein CBFA2T1 isoform 3; protein CBFA2T1; runt-related transcription factor 1; translocated to, 1 (cyclin D-related)", "tax_id": 10090, "disease": "", "pathway": " (mmu:12395)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;23527555;31219806;36064547;38992040;8575770", "class_list": "", "function": "MTG8 interacts with LHX6 to specify cortical interneuron subtype identity. Publication Status: Online-Only, [RefSeq, PubMed]; The transcriptional co-repressor Runx1t1 is essential for MYCN-driven neuroblastoma tumorigenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Can repress the expression of MMP7 in a ZBTB33-dependent manner. Can repress transactivation mediated by TCF12 (By similarity). Acts as a negative regulator of adipogenesis (PubMed:23527555)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0003714 transcription corepressor activity;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0017053 transcription repressor complex;GO:0016363 nuclear matrix", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0010977 negative regulation of neuron projection development;GO:0045444 fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q61909-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7M6Y6-1", "uniprot_id": [ { "id": "MRO2B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7M6Y6", "type": "external" } ], "mass": 180480.0, "length": 1581, "protein_name": "Maestro heat-like repeat-containing protein family member 2B", "gene_name": "Mroh2b", "organism": "Mouse", "refseq_name": "maestro heat-like repeat-containing protein family member 2B", "refseq_ac": [ { "id": "NP_001159538", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159538", "type": "external" } ], "gene_names_uniprotkb": "Mroh2b; Heatr7b2", "gene_names_refseq": "4930455B06Rik; Heatr7b2; Mroh2b; SPIF", "protein_names_uniprotkb": "Maestro heat-like repeat-containing protein family member 2B; HEAT repeat-containing protein 7B2; SPIF; Sperm PKA-interacting factor", "protein_names_refseq": "HEAT repeat-containing protein 7B2; XVHEAT repeat family member 7B2; maestro heat-like repeat-containing protein family member 2B; sperm PKA interacting factor", "tax_id": 10090, "disease": "", "pathway": " (mmu:223825)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12783626;22645316;27105888;31219806", "class_list": "", "function": "May play a role in the process of sperm capacitation (PubMed:27105888)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A096XFP7;A0A096XFP8", "ec_number_list": [], "go_molecular_function": "GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0001669 acrosomal vesicle;GO:0036126 sperm flagellum;GO:0097225 sperm midpiece", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0141156 cAMP/PKA signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q7M6Y6-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CJ19-1", "uniprot_id": [ { "id": "MICA3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CJ19", "type": "external" } ], "mass": 223721.0, "length": 1993, "protein_name": "[F-actin]-monooxygenase MICAL3", "gene_name": "Mical3", "organism": "Mouse", "refseq_name": "[F-actin]-monooxygenase MICAL3 isoform 1", "refseq_ac": [ { "id": "NP_001257404", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257404", "type": "external" } ], "gene_names_uniprotkb": "Mical3; Kiaa0819; Kiaa1364", "gene_names_refseq": "C130040D16Rik; Mical-3; Mical3; mKIAA1364", "protein_names_uniprotkb": "[F-actin]-monooxygenase MICAL3; 1.14.13.225; MICAL-3; Molecule interacting with CasL protein 3", "protein_names_refseq": "[F-actin]-methionine sulfoxide oxidase MICAL3; [F-actin]-monooxygenase MICAL3 isoform 1; [F-actin]-monooxygenase MICAL3; flavoprotein oxidoreductase MICAL3; molecule interacting with CasL protein 3; protein-methionine sulfoxide oxidase MICAL3", "tax_id": 10090, "disease": "", "pathway": " (mmu:194401)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "20173027;21183079;21750661;25428506;30084848;34418053;34428180", "class_list": "", "function": "Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and play a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "B2RR77;Q3UGQ8;Q3V160;Q69ZY5;Q80TE8;Q8BXB1", "ec_number_list": [ { "id": "1.14.13.225", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.225", "type": "external" }, { "id": "1.6.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.1", "type": "external" } ], "go_molecular_function": "GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen;GO:0060090 molecular adaptor activity;GO:0003779 actin binding;GO:0046872 metal ion binding;GO:0071949 FAD binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005819 spindle;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0051301 cell division;GO:0030036 actin cytoskeleton organization;GO:0007010 cytoskeleton organization;GO:0006887 exocytosis;GO:0019417 sulfur oxidation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8CJ19-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VDP3-1", "uniprot_id": [ { "id": "MICA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VDP3", "type": "external" } ], "mass": 116785.0, "length": 1048, "protein_name": "[F-actin]-monooxygenase MICAL1", "gene_name": "Mical1", "organism": "Mouse", "refseq_name": "[F-actin]-monooxygenase MICAL1 isoform 2", "refseq_ac": [ { "id": "NP_001157905", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157905", "type": "external" } ], "gene_names_uniprotkb": "Mical1; Mical; Nical", "gene_names_refseq": "MICAL-1; MICAL; Mical1; Nical", "protein_names_uniprotkb": "[F-actin]-monooxygenase MICAL1; 1.14.13.225; 1.6.3.1; MICAL-1; Molecule interacting with CasL protein 1; NEDD9-interacting protein with calponin homology and LIM domains; mMical1", "protein_names_refseq": "CasL interacting molecule MICAL; NEDD9-interacting protein with calponin homology and LIM domains; [F-actin]-methionine sulfoxide oxidase MICAL1; [F-actin]-monooxygenase MICAL1 isoform 2; [F-actin]-monooxygenase MICAL1; microtubule associated monoxygenase, calponin and LIM domain containing 1; molecule interacting with CasL protein 1; protein-methionine sulfoxide oxidase MICAL1", "tax_id": 10090, "disease": "", "pathway": " (mmu:171580)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "16275925;18094055;21183079;21730291;21750661;23911929;25007825;26495903;26935886;32749237;33647394;34428180;39344934;39627609;40021952", "class_list": "", "function": "Esults suggest that the CH domain, which is loosely connected to the MO domain by a flexible linker and is far away from the catalytic site, couples F-actin to the enhancement of redox activity of MICALMO-CH by a cooperative mechanism involving a trans interaction between adjacently bound molecules. Publication Status: Online-Only, [RefSeq, PubMed]; Findings show a biological role for MICAL-1 in apoptosis and define a novel negative regulatory mechanism of MST-NDR signaling., [RefSeq, PubMed]; MICAL1 (molecule interacting with CasL 1) protects oligodendrocyte cells from oxidative injury through regulating apoptosis, autophagy in spinal cord injury., [RefSeq, PubMed]; MICAL1 constrains cardiac stress responses and protects against disease by oxidizing CaMKII., [RefSeq, PubMed]; Mical1 deletion in tyrosinase expressing cells affects mouse running gaits., [RefSeq, PubMed]; Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (By similarity). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation of lamina-specific connectivity in the nervous system such as the development of lamina-restricted hippocampal connections. Through redox regulation of the actin cytoskeleton controls the intracellular distribution of secretory vesicles containing L1/neurofascin/NgCAM family proteins in neurons, thereby regulating their cell surface levels. May act as Rab effector protein and play a role in vesicle trafficking. Promotes endosomal tubule extension by associating with RAB8 (RAB8A or RAB8B), RAB10 and GRAF (GRAF1/ARHGAP26 or GRAF2/ARHGAP10) on the endosomal membrane which may connect GRAFs to Rabs, thereby participating in neosynthesized Rab8-Rab10-Rab11-dependent protein export (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D3Z4C6;E9PXR1;Q3TB77;Q3TBH9;Q3TX89", "ec_number_list": [ { "id": "1.6.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.1", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "1.14.13.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.8", "type": "external" }, { "id": "1.6.99.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.99.1", "type": "external" }, { "id": "1.14.13.225", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.225", "type": "external" } ], "go_molecular_function": "GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen;GO:0003779 actin binding;GO:0017124 SH3 domain binding;GO:0019901 protein kinase binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005884 actin filament;GO:0005886 plasma membrane", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0030036 actin cytoskeleton organization;GO:1903305 regulation of regulated secretory pathway;GO:0019417 sulfur oxidation;GO:0030042 actin filament depolymerization", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q8VDP3-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q924K8-1", "uniprot_id": [ { "id": "MTA3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q924K8", "type": "external" } ], "mass": 67077.0, "length": 591, "protein_name": "Metastasis-associated protein MTA3", "gene_name": "Mta3", "organism": "Mouse", "refseq_name": "metastasis-associated protein MTA3 isoform 4", "refseq_ac": [ { "id": "NP_001164525", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164525", "type": "external" } ], "gene_names_uniprotkb": "Mta3", "gene_names_refseq": "1110002J22Rik; Mta3; mKIAA1266", "protein_names_uniprotkb": "Metastasis-associated protein MTA3", "protein_names_refseq": "metastasis-associated protein MTA3 isoform 4; metastasis-associated protein MTA3", "tax_id": 10090, "disease": "", "pathway": " (mmu:116871); (R-MMU-3214815); (R-MMU-73762); (R-MMU-8943724); (R-MMU-9937850); (R-MMU-9940951)", "pathway_count": 6, "publication_count": 9, "publication_id_list": "11483358;18067919;21183079;21750661;23386199;25605945;31219806;34180153;34428180", "class_list": "", "function": "Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These results demonstrate the importance of FOG-2/MTA/RbAp interactions for FOG-2-mediated transcriptional repression and further define the molecular interactions between the FOG repression motif and the NuRD complex., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VC18", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity;GO:0042826 histone deacetylase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016581 NuRD complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0008284 positive regulation of cell population proliferation;GO:0010971 positive regulation of G2/M transition of mitotic cell cycle;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q924K8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CRB8-1", "uniprot_id": [ { "id": "MTFP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CRB8", "type": "external" } ], "mass": 18314.0, "length": 166, "protein_name": "Mitochondrial fission process protein 1", "gene_name": "Mtfp1", "organism": "Mouse", "refseq_name": "mitochondrial fission process protein 1", "refseq_ac": [ { "id": "NP_080719", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080719", "type": "external" } ], "gene_names_uniprotkb": "Mtfp1; Mtp18", "gene_names_refseq": "1700020C11Rik; 2610507A21Rik; Mtfp1; Mtp18", "protein_names_uniprotkb": "Mitochondrial fission process protein 1; MTP18; Mitochondrial 18 kDa protein", "protein_names_refseq": "mitochondrial 18 kDa protein; mitochondrial fission process protein 1; mitochondrial fission protein MTP18", "tax_id": 10090, "disease": "Parkinson's disease 6 (Disease Ontology:DOID:0060369); neuroblastoma (Disease Ontology:DOID:769)", "pathway": " (mmu:67900)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "23806337;28643438;28918902;30325740;31219806;36333300;38042218;38123539", "class_list": "", "function": "Data provide direct evidence for cell survival upon mTOR inhibition through mitochondrial hyperfusion employing MTFP1 as a critical effector of mTORC1 to govern cell fate decisions., [RefSeq, PubMed]; Identifying Acss1, Mtfp1 and Oxct1 as key regulators and promising biomarkers of sarcopenia in various models., [RefSeq, PubMed]; Knockdown of Mtfp1 can minimize doxorubicin cardiotoxicity by inhibiting Dnm1l-mediated mitochondrial fission., [RefSeq, PubMed]; Mitochondrial Fission Process 1 controls inner membrane integrity and protects against heart failure. Publication Status: Online-Only, [RefSeq, PubMed]; Mtfp1 ablation enhances mitochondrial respiration and protects against hepatic steatosis. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role in the regulation of mitochondrial morphology. Inhibits mitochondrial fusion by creating a non-fusogenic lipid environment which affects OPA1 oligomerization and its subsequent capacity to drive fusion. This prevents defective inner mitochondrial membrane (IMM) subdomains from fusing with other mitochondria, facilitating their segregation into small MTFP1-enriched mitochondria (SMEM) which are targeted for autophagic degradation. This IMM quality control mechanism controls mitochondrial DNA levels., [UniProtKB, UniProtKB]; The results suggest that miR-668 is induced via HIF-1 in ischemic AKI and that, upon induction, miR-668 represses MTP18 to preserve mitochondrial dynamics for renal tubular cell survival and kidney protection., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CZX4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006915 apoptotic process;GO:0007005 mitochondrion organization;GO:0000266 mitochondrial fission;GO:0007006 mitochondrial membrane organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9CRB8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R190-1", "uniprot_id": [ { "id": "MTA2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R190", "type": "external" } ], "mass": 75030.0, "length": 668, "protein_name": "Metastasis-associated protein MTA2", "gene_name": "Mta2", "organism": "Mouse", "refseq_name": "metastasis-associated protein MTA2 isoform 1", "refseq_ac": [ { "id": "NP_035972", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035972", "type": "external" } ], "gene_names_uniprotkb": "Mta2; Mta1l1", "gene_names_refseq": "Mata1l1; Mta1l1; Mta2; mmta2", "protein_names_uniprotkb": "Metastasis-associated protein MTA2; Metastasis-associated 1-like 1", "protein_names_refseq": "metastais-associated gene family, member 2; metastasis-associated 1-like 1; metastasis-associated protein 2; metastasis-associated protein MTA2 isoform 1; metastasis-associated protein MTA2", "tax_id": 10090, "disease": "systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:23942); (R-MMU-3214815); (R-MMU-6804758); (R-MMU-73762); (R-MMU-8943724); (R-MMU-9937850); (R-MMU-9940951)", "pathway_count": 7, "publication_count": 28, "publication_id_list": "10444591;10984530;11368903;11749719;12124384;18250455;19224205;20173027;21183079;23806337;25428506;25428507;25605945;26495903;27806305;28011936;28935714;29187734;30084848;30779550;32816854;34180153;34203471;34428180;34887587;35820727;37828378;39627609", "class_list": "", "function": "May function as a transcriptional coregulator (By similarity). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (By similarity)., [UniProtKB, UniProtKB]; Metastasis-Associated Protein 2 Represses NF-kappaB to Reduce Lung Tumor Growth and Inflammation. Erratum:[Cancer Res. 2022 Feb 15;82(4):736. doi: 10.1158/0008-5472.CAN-21-4331. PMID: 35180307], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TVT8", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity;GO:0042826 histone deacetylase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0000118 histone deacetylase complex;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0010762 regulation of fibroblast migration;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "Q9R190-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTJ6-1", "uniprot_id": [ { "id": "MTL5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WTJ6", "type": "external" } ], "mass": 50616.0, "length": 475, "protein_name": "Tesmin", "gene_name": "Tesmin", "organism": "Mouse", "refseq_name": "tesmin isoform a", "refseq_ac": [ { "id": "NP_001034746", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034746", "type": "external" } ], "gene_names_uniprotkb": "Tesmin; Mtl5", "gene_names_refseq": "Mtl5; Tesmin", "protein_names_uniprotkb": "Tesmin; Metallothionein-like 5, testis-specific; Testis-specific metallothionein-like protein", "protein_names_refseq": "metallothionein-like 5, testis-specific (tesmin); tesmin isoform a; testis-specific metallothionein-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:17771)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10191092;11803038;12606435;14648882;21183079;31916570;34388164;35249447", "class_list": "", "function": "Data suggest that tesmin transcription may be controlled by two different mechanisms during male and female meiosis., [RefSeq, PubMed]; Essential for normal spermatogenesis and male fertility (PubMed:31916570). Required for the completion of meiosis in male germ cells (PubMed:31916570)., [UniProtKB, PubMed]; Metallothionein-like 5 expression is correlated with poor prognosis and promotes proliferation of cervical squamous cell carcinoma., [RefSeq, PubMed]; Nuclear translocation of MTL5 from cytoplasm requires its direct interaction with LIN9 and is essential for male meiosis and fertility. Publication Status: Online-Only, [RefSeq, PubMed]; Regulation of the tesmin nucleocytoplasmic shuttling by the effect of metal stress, [RefSeq, PubMed]; Tesmin is involved in multiple stages of spermatogenesis and spermiogenesis, [RefSeq, PubMed]; Tesmin, Metallothionein-Like 5, is Required for Spermatogenesis in Micedagger., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q548K4;Q8VIE0;Q8VIE1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0006355 regulation of DNA-templated transcription;GO:0007140 male meiotic nuclear division", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9WTJ6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2D1-1", "uniprot_id": [ { "id": "MTMR2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z2D1", "type": "external" } ], "mass": 73232.0, "length": 643, "protein_name": "Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2", "gene_name": "Mtmr2", "organism": "Mouse", "refseq_name": "phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2 isoform 1", "refseq_ac": [ { "id": "NP_076347", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076347", "type": "external" } ], "gene_names_uniprotkb": "Mtmr2", "gene_names_refseq": "6030445P13Rik; Mtmr2", "protein_names_uniprotkb": "Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2; 3.1.3.95; Myotubularin-related protein 2; Phosphatidylinositol-3-phosphate phosphatase", "protein_names_refseq": "phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2 isoform 1; phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2; phosphatidylinositol-3,5-bisphosphate 3-phosphatase; phosphatidylinositol-3-phosphate phosphatase", "tax_id": 10090, "disease": "Charcot-Marie-Tooth disease type 4B1 (Disease Ontology:DOID:0110191); centronuclear myopathy X-linked (Disease Ontology:DOID:0111225); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); myopathy (Disease Ontology:DOID:423)", "pathway": " (mmu:77116); (R-MMU-1483248); (R-MMU-1660516); (R-MMU-1660517)", "pathway_count": 4, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;12045210;14530412;16399794;17242355;21183079;21750661;23297362;25428506;28589938;28934386;29521261;30084848;32782141;34428180;34718573;9736772", "class_list": "", "function": "Analysis of epistasis between Mtm1 and Dnm2 reveal possibilities for DNM2 knockdown as a therapeutic approach for X-linked centronuclear myopathy (XLCNM), or myotubular myopathy Publication Status: Online-Only, [RefSeq, PubMed]; Expression of several MTMR2 isoforms ameliorates the myopathic phenotype owing to MTM1 loss, with increased muscle force, reduced myofiber atrophy, and reduction of the intracellular disorganization hallmarks associated with myotubular myopathy., [RefSeq, PubMed]; Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate (PubMed:12045210, PubMed:16399794). Regulates the level of these phosphoinositides critical for various biological processes including autophagy initiation and autophagosome maturation (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Loss of phosphatase activity in myotubularin-related protein 2 is associated with Charcot-Marie-Tooth disease type 4B1, [RefSeq, PubMed]; Mtmr2 forms a dimer and the C-terminal coiled-coil is responsible for homodimerization, in addition to membrane association, [RefSeq, PubMed]; We identified a PI(3,5)P2 binding region in Piezo2, but not Piezo1, that confers sensitivity to Mtmr2 as indicated by functional analysis of a domain-swapped Piezo2 mutant. Altogether, our results propose local PI(3,5)P2 modulation via Mtmr2 in the vicinity of Piezo2 as a novel mechanism to dynamically control Piezo2-dependent mechanotransduction in peripheral sensory neurons. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B8JJF4;Q8VHA7", "ec_number_list": [ { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.95", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.95", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.64", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.64", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity;GO:0052866 phosphatidylinositol phosphate phosphatase activity;GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0014069 postsynaptic density;GO:0016020 membrane", "go_biological_process": "GO:0016311 dephosphorylation;GO:0045806 negative regulation of endocytosis;GO:0060304 regulation of phosphatidylinositol dephosphorylation;GO:0048666 neuron development;GO:0002091 negative regulation of receptor internalization", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q9Z2D1-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5HZI1-1", "uniprot_id": [ { "id": "MTUS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5HZI1", "type": "external" } ], "mass": 134379.0, "length": 1210, "protein_name": "Microtubule-associated tumor suppressor 1 homolog", "gene_name": "Mtus1", "organism": "Mouse", "refseq_name": "microtubule-associated tumor suppressor 1 homolog isoform 1", "refseq_ac": [ { "id": "NP_001005863", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005863", "type": "external" } ], "gene_names_uniprotkb": "Mtus1; Atbp; Atip; Cctsg1; Kiaa1288; Mtsg1", "gene_names_refseq": "ATBP135; Atip1; B430010I23Rik; B430305I03Rik; Cctsg1-440; MD44; MTSG1; Mtus1; mKIAA1288", "protein_names_uniprotkb": "Microtubule-associated tumor suppressor 1 homolog; AT2 receptor-binding protein; Angiotensin-II type 2 receptor-interacting protein; Coiled-coiled tumor suppressor gene 1 protein; Mitochondrial tumor suppressor 1 homolog", "protein_names_refseq": "AT2 receptor-binding protein; angiotensin II AT2 receptor-interacting protein 1; angiotensin-II type 2 receptor-interacting protein; coiled-coiled tumor suppressor gene 1 protein; coiled-coiled tumor supressor gene 1; microtubule-associated tumor suppressor 1 homolog isoform 1; microtubule-associated tumor suppressor 1 homolog; mitochondrial tumor suppressor 1 homolog", "tax_id": 10090, "disease": "tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); colon cancer (Disease Ontology:DOID:219); breast carcinoma (Disease Ontology:DOID:3459); ovarian carcinoma (Disease Ontology:DOID:4001); salivary gland adenoid cystic carcinoma (Disease Ontology:DOID:4866); gallbladder carcinoma (Disease Ontology:DOID:4948)", "pathway": " (mmu:102103)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "15123706;15539617;17068200;17242355;21183079;21750661;23565185;24288149;26471325;31219806;34418053;34428180;35820727", "class_list": "", "function": "ATIP1 could exert anti-inflammatory effects in adipose tissue via macrophage polarization associated with improvement of insulin resistance., [RefSeq, PubMed]; ATIPs seem to be mainly involved in the developmental regulation of the cardiovascular system and may act in different AT2-dependent and -independent manners., [RefSeq, PubMed]; Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation., [UniProtKB, PubMed, PubMed, PubMed]; Important role in AT2 receptor-mediated PPARgamma activation, [RefSeq, PubMed]; Results identify ATIP1 (angiotensin II AT2 receptor-interacting protein) as a novel early component of growth inhibitory signaling cascade., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3UP60;Q6ITD2;Q6ZPU5;Q80YG5;Q80YV9;Q80ZZ2;Q8BH23;Q8BMM8;Q8C0C8", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0010758 regulation of macrophage chemotaxis", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q5HZI1-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62132-1", "uniprot_id": [ { "id": "PTPRR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62132", "type": "external" } ], "mass": 74036.0, "length": 656, "protein_name": "Receptor-type tyrosine-protein phosphatase R", "gene_name": "Ptprr", "organism": "Mouse", "refseq_name": "receptor-type tyrosine-protein phosphatase R isoform b", "refseq_ac": [ { "id": "NP_001155309", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155309", "type": "external" } ], "gene_names_uniprotkb": "Ptprr; Ptp13", "gene_names_refseq": "Gmcp1; PTP-SL; PTPBR7; Ptprr; RPTPRR; mPTP213", "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase R; 3.1.3.48; Phosphotyrosine phosphatase 13; Protein-tyrosine-phosphatase SL; R-PTP-R", "protein_names_refseq": "R-PTP-R; STEP-like PTPase; phosphotyrosine phosphatase 13; protein-tyrosine-phosphatase-SL; receptor-type tyrosine-protein phosphatase R isoform b; receptor-type tyrosine-protein phosphatase R", "tax_id": 10090, "disease": "", "pathway": " (mmu:19279)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;10601328;10705342;10949045;21183079;21850207;24556203;25571783;7832766;7836467", "class_list": "", "function": "Results support the suggested link between PTPRR isoforms and cerebellar calcium ion homeostasis, and suggest an additional role in the process of cell-cell adhesion, [RefSeq, PubMed]; Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus. Isoform gamma may have a role in patterning and cellular proliferation of skeletal elements in the precartilaginous/cartilaginous skeleton., [UniProtKB, PubMed, PubMed]; The data of this study disclosed a distinct role for PTPRR in recognition memory and exploration of a new environment., [RefSeq, PubMed]; These findings indicate an important role for PTPRR in maintaining low basal mitogen-activated protein kinase activity in Purkinje cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q64491;Q64492;Q9QUH9", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" } ], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030054 cell junction", "go_biological_process": "GO:0010633 negative regulation of epithelial cell migration;GO:0001701 in utero embryonic development;GO:0007165 signal transduction;GO:0070373 negative regulation of ERK1 and ERK2 cascade;GO:0006470 protein dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q62132-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.1000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WU42-1", "uniprot_id": [ { "id": "NCOR2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WU42", "type": "external" } ], "mass": 269807.0, "length": 2472, "protein_name": "Nuclear receptor corepressor 2", "gene_name": "Ncor2", "organism": "Mouse", "refseq_name": "nuclear receptor corepressor 2 isoform 2", "refseq_ac": [ { "id": "NP_001240833", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240833", "type": "external" } ], "gene_names_uniprotkb": "Ncor2; Smrt", "gene_names_refseq": "N-CoR; Ncor2; SMRTe; SMRT", "protein_names_uniprotkb": "Nuclear receptor corepressor 2; N-CoR2; SMRTe; SMRT; Silencing mediator of retinoic acid and thyroid hormone receptor; T3 receptor-associating factor; TRAC; Thyroid-, retinoic-acid-receptor-associated corepressor", "protein_names_refseq": "N-CoR2; T3 receptor-associating factor; TRAC; nuclear receptor corepressor 2 isoform 2; nuclear receptor corepressor 2; silencing mediator of retinoic acid and thyroid hormone receptor; silencing mediator of retinoid acid and thyroid hormone receptor; thyroid-, retinoic-acid-receptor-associated corepressor", "tax_id": 10090, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); breast cancer (Disease Ontology:DOID:1612); endometrial carcinoma (Disease Ontology:DOID:2871); myelofibrosis (Disease Ontology:DOID:4971); osteoarthritis (Disease Ontology:DOID:8398)", "pathway": " (mmu:20602); (R-MMU-2173795); (R-MMU-350054); (R-MMU-381340); (R-MMU-383280); (R-MMU-400206); (R-MMU-9029569); (R-MMU-9623433); (R-MMU-9707564); (R-MMU-9841922)", "pathway_count": 10, "publication_count": 37, "publication_id_list": "10.1101/2023.09.13.557529;10.3389/fragi.2021.757801;10077563;10097068;10640276;11533236;17242355;19144319;19144721;21183079;21606357;21750661;22517741;22645316;23455674;23770565;23806337;24129315;25428506;29237092;30059200;30084848;31219806;31599954;32782141;32848054;33831416;34428180;34678516;35822049;36210013;36454860;36852467;40021952;40885482;40997131;9405624", "class_list": "", "function": "Nuclear corepressor SMRT acts as a strong regulator of both beta-oxidation and suppressor of fibrosis in the differentiation process of mouse skeletal muscle cells. Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptional corepressor that mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Acts by recruiting chromatin modifiers, such as histone deacetylases HDAC1, HDAC2 and HDAC3. Required to activate the histone deacetylase activity of HDAC3. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 19, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 19, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 19, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 33, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 5, "glyco_site_count": 22, "binding_glycan_count": 0, "secondary_ac_list": "E9Q9V0;Q9WU43;Q9WUC1", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008047 enzyme activator activity;GO:0003714 transcription corepressor activity;GO:0035259 nuclear glucocorticoid receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0017053 transcription repressor complex;GO:0016604 nuclear body;GO:0016363 nuclear matrix", "go_biological_process": "GO:0010565 regulation of ketone metabolic process;GO:0060816 random inactivation of X chromosome;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 6.0, "record_id": "Q9WU42-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97318-1", "uniprot_id": [ { "id": "DAB1_MOUSE", "url": "https://www.uniprot.org/uniprot/P97318", "type": "external" } ], "mass": 63578.0, "length": 588, "protein_name": "Disabled homolog 1", "gene_name": "Dab1", "organism": "Mouse", "refseq_name": "disabled homolog 1 isoform 1", "refseq_ac": [ { "id": "NP_034144", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034144", "type": "external" } ], "gene_names_uniprotkb": "Dab1", "gene_names_refseq": "C630028C02Rik; Dab1; mDab1; scm; scrambler; scr; yot", "protein_names_uniprotkb": "Disabled homolog 1; mDab1", "protein_names_refseq": "disabled homolog 1 isoform 1; disabled homolog 1; yotari", "tax_id": 10090, "disease": "spinocerebellar ataxia 37 (Disease Ontology:DOID:0050984); autistic disorder (Disease Ontology:DOID:12849); status epilepticus (Disease Ontology:DOID:1824)", "pathway": " (mmu:13131); (R-MMU-8866376)", "pathway_count": 2, "publication_count": 21, "publication_id_list": "10959835;11279201;12077184;12526739;12646221;12737822;12826668;14517291;15062102;15110774;17974915;19796633;21750661;24210661;29361558;32641498;35989311;36979337;9009273;9338784;9338785", "class_list": "", "function": "Immunoexpression Pattern of Autophagy Markers in Developing and Postnatal Kidneys of Dab1[-/-](yotari) Mice. Publication Status: Online-Only, [RefSeq, PubMed]; Signaling adapter of the reelin-mediated signaling pathway, which regulates the migration and differentiation of postmitotic neurons during brain development (PubMed:12526739, PubMed:9009273, PubMed:9338784, PubMed:9338785). Mediates intracellular transduction of Reelin signaling following reelin (RELN)-binding to its receptor: acts by docking proteins through its phosphotyrosine residues and PID domain (PubMed:12526739, PubMed:9009273, PubMed:9338784, PubMed:9338785)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A2A963;A2A964;A2A965;A2A966;A2A967;A2A970;P97316;P97317;Q9DAP9", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0042169 SH2 domain binding;GO:0035591 signaling adaptor activity;GO:0043548 phosphatidylinositol 3-kinase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005903 brush border;GO:0043025 neuronal cell body;GO:0045177 apical part of cell", "go_biological_process": "GO:0021799 cerebral cortex radially oriented cell migration;GO:0007162 negative regulation of cell adhesion;GO:0007399 nervous system development;GO:0016358 dendrite development;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P97318-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62406-1", "uniprot_id": [ { "id": "IRAK1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62406", "type": "external" } ], "mass": 77269.0, "length": 710, "protein_name": "Interleukin-1 receptor-associated kinase 1", "gene_name": "Irak1", "organism": "Mouse", "refseq_name": "interleukin-1 receptor-associated kinase 1 isoform 4", "refseq_ac": [ { "id": "NP_001171445", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171445", "type": "external" } ], "gene_names_uniprotkb": "Irak1; Il1rak", "gene_names_refseq": "IRAK-1; IRAK1-S; IRAK1b; IRAK; Il1rak; Irak1; Plpk; mPLK", "protein_names_uniprotkb": "Interleukin-1 receptor-associated kinase 1; 2.7.11.1; IRAK-1; IRAK; Pelle-like protein kinase; mPLK", "protein_names_refseq": "interleukin-1 receptor-associated kinase 1 isoform 4; interleukin-1 receptor-associated kinase-1b; pelle-like protein kinase", "tax_id": 10090, "disease": "cognitive disorder (Disease Ontology:DOID:1561); diffuse scleroderma (Disease Ontology:DOID:1580); squamous cell carcinoma (Disease Ontology:DOID:1749); brain ischemia (Disease Ontology:DOID:2316); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); primary immunodeficiency disease (Disease Ontology:DOID:612); ankylosing spondylitis (Disease Ontology:DOID:7147); psoriasis (Disease Ontology:DOID:8893); psoriatic arthritis (Disease Ontology:DOID:9008)", "pathway": " (mmu:16179); (R-MMU-1257604); (R-MMU-209543); (R-MMU-209560); (R-MMU-445989); (R-MMU-450302); (R-MMU-450321); (R-MMU-6811558); (R-MMU-9020702); (R-MMU-937039); (R-MMU-975144)", "pathway_count": 11, "publication_count": 18, "publication_id_list": "10723722;11096118;12138165;12370331;12538665;15767370;16951688;21435586;21743479;21750661;22037600;25428506;26512959;34428180;36765034;37311534;38367238;8663605", "class_list": "", "function": "IRAK-M suppresses the activation of microglial NLRP3 inflammasome and GSDMD-mediated pyroptosis through inhibiting IRAK1 phosphorylation during experimental autoimmune encephalomyelitis. Publication Status: Online-Only, [RefSeq, PubMed]; Phosphorylation of USP20 on Ser334 by IRAK1 promotes IL-1beta-evoked signaling in vascular smooth muscle cells and vascular inflammation., [RefSeq, PubMed]; Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3 (By similarity)., [UniProtKB, PubMed]; The IRAK1/IRF5 axis initiates IL-12 response by dendritic cells and control of Toxoplasma gondii infection., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AUW4;Q6Y3Z5;Q6Y3Z6", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0005829 cytosol", "go_biological_process": "GO:0070498 interleukin-1-mediated signaling pathway;GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell;GO:0006468 protein phosphorylation;GO:0032496 response to lipopolysaccharide;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q62406-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TN99-1", "uniprot_id": [ { "id": "CPEB3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TN99", "type": "external" } ], "mass": 78335.0, "length": 716, "protein_name": "Cytoplasmic polyadenylation element-binding protein 3", "gene_name": "Cpeb3", "organism": "Mouse", "refseq_name": "cytoplasmic polyadenylation element-binding protein 3 isoform a", "refseq_ac": [ { "id": "NP_001277755", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277755", "type": "external" } ], "gene_names_uniprotkb": "Cpeb3; Kiaa0940", "gene_names_refseq": "4831444O18Rik; CPE-BP3; Cpeb3; mKIAA0940", "protein_names_uniprotkb": "Cytoplasmic polyadenylation element-binding protein 3; CPE-BP3; CPE-binding protein 3; mCPEB-3", "protein_names_refseq": "CPE-binding protein 3; cytoplasmic polyadenylation element-binding protein 3 isoform a", "tax_id": 10090, "disease": "", "pathway": " (mmu:208922)", "pathway_count": 1, "publication_count": 29, "publication_id_list": "12871996;17024188;17114649;20003455;20639532;21183079;21750661;22153079;22711986;22730302;22872234;24129315;24155305;26074003;26074071;26074072;26915043;26915047;30084848;30779550;31599954;34428180;35675768;36068334;36852467;38000031;38319152;38786074;40021952", "class_list": "", "function": "CPEB3 Maintains Developmental Competence of the Oocyte. Publication Status: Online-Only, [RefSeq, PubMed]; CPEB3 is a sequence-specific translational regulatory protein., [RefSeq, PubMed]; CPEB3 is expressed in the principal cell layers of the hippocampus, [RefSeq, PubMed]; CPEB3 suppresses gastric cancer progression by inhibiting ADAR1-mediated RNA editing via localizing ADAR1 mRNA to P bodies., [RefSeq, PubMed]; CPEB3-dependent increase in GluA2 subunits impairs excitatory transmission onto inhibitory interneurons in a mouse model of fragile X., [RefSeq, PubMed]; Inhibition of Cpeb3 ribozyme elevates CPEB3 protein expression and polyadenylation of its target mRNAs and enhances object location memory. Publication Status: Online-Only, [RefSeq, PubMed]; MicroRNA-92a-CPEB3 axis protects neurons against inflammatory neurodegeneration., [RefSeq, PubMed]; Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimulated state but, following neuronal stimulation, acts as a translational activator (PubMed:17024188, PubMed:26074072). In contrast to CPEB1, does not bind to the cytoplasmic polyadenylation element (CPE), a uridine-rich sequence element within the mRNA 3'-UTR, but binds to a U-rich loop within a stem-loop structure (PubMed:17024188). Required for the consolidation and maintenance of hippocampal-based long term memory (PubMed:26074003). In the basal state, binds to the mRNA 3'-UTR of the glutamate receptors GRIA1 and GRIA2 and negatively regulates their translation (PubMed:17024188, PubMed:22153079). Also represses the translation of DLG4, GRIN1 GRIN2A and GRIN2B (PubMed:24155305). When activated, acts as a translational activator of GRIA1 and GRIA2 (PubMed:22153079, PubMed:26074003). In the basal state, suppresses SUMO2 translation but activates it following neuronal stimulation (PubMed:26074071). Binds to the 3'-UTR of TRPV1 mRNA and represses TRPV1 translation which is required to maintain normal thermoception (PubMed:26915043). Binds actin mRNA, leading to actin translational repression in the basal state and to translational activation following neuronal stimulation (PubMed:26074072). Negatively regulates target mRNA levels by binding to TOB1 which recruits CNOT7/CAF1 to a ternary complex and this leads to target mRNA deadenylation and decay (By similarity). In addition to its role in translation, binds to and inhibits the transcriptional activation activity of STAT5B without affecting its dimerization or DNA-binding activity. This, in turn, represses transcription of the STAT5B target gene EGFR which has been shown to play a role in enhancing learning and memory performance (By similarity). In contrast to CPEB1, CPEB2 and CPEB4, not required for cell cycle progression (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Show that CPEB3 expression is increased in a time-dependent manner during the course of postnatal development, and CPEB3 is localized mostly in the inner retina, including retinal ganglion cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A1A562;Q3TT89;Q3UHR6;Q8CHC2", "ec_number_list": [], "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity;GO:0003723 RNA binding;GO:0008135 translation factor activity, RNA binding;GO:0043022 ribosome binding;GO:0003730 mRNA 3'-UTR binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:1900273 positive regulation of long-term synaptic potentiation;GO:0048167 regulation of synaptic plasticity;GO:0017148 negative regulation of translation;GO:0045727 positive regulation of translation", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "Q7TN99-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8JZN7-1", "uniprot_id": [ { "id": "MIRO2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8JZN7", "type": "external" } ], "mass": 69071.0, "length": 620, "protein_name": "Mitochondrial Rho GTPase 2", "gene_name": "Rhot2", "organism": "Mouse", "refseq_name": "mitochondrial Rho GTPase 2 isoform 1", "refseq_ac": [ { "id": "NP_666111", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666111", "type": "external" } ], "gene_names_uniprotkb": "Rhot2; Arht2", "gene_names_refseq": "Arht2; Miro2; Rhot2", "protein_names_uniprotkb": "Mitochondrial Rho GTPase 2; 3.6.5.-; MIRO-2; Ras homolog gene family member T2", "protein_names_refseq": "mitochondrial Rho 2; mitochondrial Rho GTPase 2 isoform 1; mitochondrial Rho GTPase 2; ras homolog gene family, member T2", "tax_id": 10090, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:214952); (R-MMU-9013419)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "15218247;21750661;22569362;27705781;29311115;31219806;31455181;31562315;34428180;37507081", "class_list": "", "function": "Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro 1/2 and Trak2. Publication Status: Online-Only, [RefSeq, PubMed]; Atypical mitochondrial nucleoside-triphosphatase (NTPase) involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution. Can hydrolyze GTP, ATP and UTP (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Both Miro proteins can act to coordinate microtubule-dependent and actin-dependent mitochondrial trafficking, Miro1 preferentially acts to control microtubule-dependent trafficking through kinesin and dynein, while Miro2 plays a more prominent role in coordinating mitochondrial interactions with the actin cytoskeleton through a more efficient recruitment and stability of endogenous Myo19 in the mitochondrial membrane., [RefSeq, PubMed]; Mitochondrial Miro2 expression levels regulate inter-mitochondrial communication along microtubules in adult cardiomyocytes. Degradation of Miro2 through Parkin-mediated ubiquitination contributes to impaired inter-mitochondrial communication and cardiac dysfunction during hypertrophic heart diseases., [RefSeq, PubMed]; Molecular cloning and characterization of a novel mouse cDNA encoding a putative atypical GTPase protein, Arht2, [RefSeq, PubMed]; Using knockout mouse embryonic fibroblasts, data show that mitochondrial Rho (Miro) GTPases Miro1 and Miro2 are required for normal mitochondrial cristae architecture and endoplasmic reticulum-mitochondria contacts Sites (ERMCS). Publication Status: Online-Only, [RefSeq, PubMed]; Using mouse knockout strategies, we demonstrate that Miro1, as opposed to Miro2, is the primary regulator of mitochondrial transport in both axons and dendrites. Miro1 deletion leads to depletion of mitochondria from distal dendrites but not axons, accompanied by a marked reduction in dendritic complexity. Disrupting postnatal mitochondrial distribution in vivo by deleting Miro1 in mature neurons causes a progressive loss, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.6.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.42", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0016887 ATP hydrolysis activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0047497 mitochondrion transport along microtubule;GO:0019725 cellular homeostasis;GO:0007005 mitochondrion organization;GO:0097345 mitochondrial outer membrane permeabilization;GO:0007264 small GTPase-mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8JZN7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CWE0-1", "uniprot_id": [ { "id": "MFR1L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CWE0", "type": "external" } ], "mass": 31726.0, "length": 289, "protein_name": "Mitochondrial fission regulator 1-like", "gene_name": "Mtfr1l", "organism": "Mouse", "refseq_name": "mitochondrial fission regulator 1-like", "refseq_ac": [ { "id": "NP_001243041", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243041", "type": "external" } ], "gene_names_uniprotkb": "Mtfr1l; Fam54b", "gene_names_refseq": "2410166I05Rik; Fam54b; Mtfr1l", "protein_names_uniprotkb": "Mitochondrial fission regulator 1-like", "protein_names_refseq": "family with sequence similarity 54, member B; mitochondrial fission regulator 1-like; protein FAM54B", "tax_id": 10090, "disease": "", "pathway": " (mmu:76824)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;17242355;19144319;21183079;21750661;25153642;28135057;28528544;34428180;36367943", "class_list": "", "function": "Mitochondrial protein required for adaptation of miochondrial dynamics to metabolic changes. Regulates mitochondrial morphology at steady state and mediates AMPK-dependent stress-induced mitochondrial fragmentation via the control of OPA1 levels., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Mitochondrial protein required for adaptation of mitochondrial dynamics to metabolic changes. Regulates mitochondrial morphology at steady state and mediates AMPK-dependent stress-induced mitochondrial fragmentation via the control of OPA1 levels., [UniProtKB, PubMed]; Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UJK3;Q8BTP7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0000266 mitochondrial fission;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9CWE0-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88485-1", "uniprot_id": [ { "id": "DC1I1_MOUSE", "url": "https://www.uniprot.org/uniprot/O88485", "type": "external" } ], "mass": 70725.0, "length": 628, "protein_name": "Cytoplasmic dynein 1 intermediate chain 1", "gene_name": "Dync1i1", "organism": "Mouse", "refseq_name": "cytoplasmic dynein 1 intermediate chain 1 isoform 2", "refseq_ac": [ { "id": "NP_001177952", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001177952", "type": "external" } ], "gene_names_uniprotkb": "Dync1i1; Dnci1; Dncic1", "gene_names_refseq": "DH IC-1; DHIC-1; DIC; Dncic1; Dync1i1; IC74", "protein_names_uniprotkb": "Cytoplasmic dynein 1 intermediate chain 1; Cytoplasmic dynein intermediate chain 1; DH IC-1; Dynein intermediate chain 1, cytosolic", "protein_names_refseq": "Dynein intermediate chain 1, cytosolic (DH IC-1) (Cytoplasmic dynein intermediate chain 1); cytoplasmic dynein 1 intermediate chain 1 isoform 2; dynein, cytoplasmic, intermediate chain 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:13426); (R-MMU-141430); (R-MMU-141444); (R-MMU-2132295); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-3371497); (R-MMU-5663220); (R-MMU-6807878); (R-MMU-6811436); (R-MMU-68877); (R-MMU-9646399); (R-MMU-9648025)", "pathway_count": 13, "publication_count": 6, "publication_id_list": "10049579;11148209;16452087;21183079;21750661;40021952", "class_list": "", "function": "Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O88486;Q80W09", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0030507 spectrin binding;GO:0003777 microtubule motor activity;GO:0045503 dynein light chain binding;GO:0045504 dynein heavy chain binding", "go_cellular_component": "GO:1990257 piccolo-bassoon transport vesicle;GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005874 microtubule", "go_biological_process": "GO:0047496 vesicle transport along microtubule;GO:0010970 transport along microtubule", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O88485-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CAQ8-1", "uniprot_id": [ { "id": "MIC60_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CAQ8", "type": "external" } ], "mass": 83900.0, "length": 757, "protein_name": "MICOS complex subunit Mic60", "gene_name": "Immt", "organism": "Mouse", "refseq_name": "MICOS complex subunit Mic60 isoform 2", "refseq_ac": [ { "id": "NP_001240610", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240610", "type": "external" } ], "gene_names_uniprotkb": "Immt; Mic60", "gene_names_refseq": "1700082C19Rik; D830041H16Rik; HMP; Immt; Micos60; P87/89; P87; P89", "protein_names_uniprotkb": "MICOS complex subunit Mic60; Mitochondrial inner membrane protein; Mitofilin", "protein_names_refseq": "MICOS complex subunit Mic60 isoform 2; MICOS complex subunit Mic60; mitochondrial inner membrane protein; mitofilin", "tax_id": 10090, "disease": "", "pathway": " (mmu:76614)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;15647377;18034455;18307031;21081504;21750661;31219806;33300544;34428180;36288343;36974636;37453647;37507081;38467404;39627609;39927985;40684658", "class_list": "", "function": "Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Data show that Uchl3 and mitofilin are differentially expressed in the hippocampi of inbred senescence-acclerated mice compared to normally-aging mice., [RefSeq, PubMed]; Genetic ablation of Immt induces a lethal disruption of the MICOS complex. Publication Status: Online-Only, [RefSeq, PubMed]; Mic60 is essential to maintain mitochondrial integrity and to prevent encephalomyopathy., [RefSeq, PubMed]; Mitofilin is a critical organizer of the mitochondrial cristae morphology and thus indispensable for normal mitochondrial function, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q66JS4;Q7TNE2;Q8C7V1;Q8CCI0;Q8CDA8;Q9D9F6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0043209 myelin sheath;GO:0061617 MICOS complex", "go_biological_process": "GO:0042407 cristae formation;GO:0051560 mitochondrial calcium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q8CAQ8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53564-1", "uniprot_id": [ { "id": "CUX1_MOUSE", "url": "https://www.uniprot.org/uniprot/P53564", "type": "external" } ], "mass": 165596.0, "length": 1515, "protein_name": "Homeobox protein cut-like 1", "gene_name": "Cux1", "organism": "Mouse", "refseq_name": "homeobox protein cut-like 1 isoform c", "refseq_ac": [ { "id": "NP_001278162", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278162", "type": "external" } ], "gene_names_uniprotkb": "Cux1; Cutl1; Cux; Kiaa4047", "gene_names_refseq": "CDP; Cutl1; Cux-1; Cux1; Cux", "protein_names_uniprotkb": "Homeobox protein cut-like 1; CCAAT displacement protein; CDP; Homeobox protein cux-1", "protein_names_refseq": "CCAAT displacement protein; Cux/CDP homeoprotein; homeobox protein cut-like 1 isoform c; homeobox protein cut-like 1; homeobox protein cux-1; protein CASP", "tax_id": 10090, "disease": "stomach cancer (Disease Ontology:DOID:10534); cancer (Disease Ontology:DOID:162); hematologic cancer (Disease Ontology:DOID:2531); insulinoma (Disease Ontology:DOID:3892); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:13047)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;10373541;11544187;15099520;15371550;20510857;21183079;21750661;31219806;34428180;34887587;7910552;8840273;8879483;9332351;9858552", "class_list": "", "function": "May be involved in intra-Golgi retrograde transport., [UniProtKB]; Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1., [UniProtKB, PubMed]; Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III (PubMed:20510857). Also involved in the control of synaptogenesis (Probable). In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O08994;P70301;Q571L6;Q91ZD2", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0030674 protein-macromolecule adaptor activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0042491 inner ear auditory receptor cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0001822 kidney development", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P53564-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06151-1", "uniprot_id": [ { "id": "LDHA_MOUSE", "url": "https://www.uniprot.org/uniprot/P06151", "type": "external" } ], "mass": 36499.0, "length": 332, "protein_name": "L-lactate dehydrogenase A chain", "gene_name": "Ldha", "organism": "Mouse", "refseq_name": "L-lactate dehydrogenase A chain isoform 1", "refseq_ac": [ { "id": "NP_034829", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034829", "type": "external" } ], "gene_names_uniprotkb": "Ldha; Ldh-1; Ldh1", "gene_names_refseq": "Ldh1; Ldha; Ldhm; l7R2", "protein_names_uniprotkb": "L-lactate dehydrogenase A chain; 1.1.1.27; LDH muscle subunit; LDH-A; LDH-M", "protein_names_refseq": "L-lactate dehydrogenase A chain isoform 1; L-lactate dehydrogenase A chain; LDH muscle subunit; LDH-M; M-LDH; lactate dehydrogenase 1, A chain; lactate dehydrogenase A4", "tax_id": 10090, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); hypertension (Disease Ontology:DOID:10763); hyperglycemia (Disease Ontology:DOID:4195)", "pathway": " (mmu:16828); (R-MMU-70268); (R-MMU-9861718)", "pathway_count": 3, "publication_count": 29, "publication_id_list": "12145195;16139798;16393994;17947660;21750661;22645316;23806337;24788674;25153642;25605945;28528544;29187734;2993055;3017306;3036647;31209405;33300544;33725478;34428180;35820727;36064721;36210013;36288343;37453647;37507081;37828378;39627609;39927985;3996406", "class_list": "", "function": "Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+)., [UniProtKB, UniProtKB]; The muscle subunit of lactate dehydrogenase is an integral part of the sarcolemmal K(ATP) channel complex in vivo, where it couples the metabolic status of the cell with the K(ATP) channel activity essential for protection against ischemia., [RefSeq, PubMed]; The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to hemolytic anemia and early postimplantation death in mice. Multiple transcript variants encoding different isoforms have been found for this gene. The mouse genome contains multiple pseudogenes of this gene. [provided by RefSeq, May 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.27", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0051287 NAD binding;GO:0019900 kinase binding;GO:0004459 L-lactate dehydrogenase (NAD+) activity;GO:0004457 lactate dehydrogenase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0035686 sperm fibrous sheath;GO:1990204 oxidoreductase complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0019244 lactate biosynthetic process from pyruvate;GO:0019661 glucose catabolic process to lactate via pyruvate;GO:0006089 lactate metabolic process;GO:0042867 pyruvate catabolic process;GO:0019752 carboxylic acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "P06151-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91Y86-1", "uniprot_id": [ { "id": "MK08_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91Y86", "type": "external" } ], "mass": 44229.0, "length": 384, "protein_name": "Mitogen-activated protein kinase 8", "gene_name": "Mapk8", "organism": "Mouse", "refseq_name": "mitogen-activated protein kinase 8 isoform 1", "refseq_ac": [ { "id": "NP_057909", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_057909", "type": "external" } ], "gene_names_uniprotkb": "Mapk8; Jnk1; Prkm8", "gene_names_refseq": "JNK1; JNK; Mapk8; Prkm8; SAPK1", "protein_names_uniprotkb": "Mitogen-activated protein kinase 8; 2.7.11.24; MAP kinase 8; MAPK 8; Stress-activated protein kinase JNK1; c-Jun N-terminal kinase 1", "protein_names_refseq": "JNK1 beta1 protein kinase; MAP kinase 8; MAPK 8; c-Jun N-terminal kinase 1; mitogen-activated protein kinase 8 isoform 1; protein kinase mitogen-activated 8; stress-activated protein kinase JNK1", "tax_id": 10090, "disease": "colorectal adenoma (Disease Ontology:DOID:0050860); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); stroke (Disease Ontology:DOID:0051061); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Parkinsonism (Disease Ontology:DOID:0080855); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); rectal benign neoplasm (Disease Ontology:DOID:1984); chronic mucocutaneous candidiasis (Disease Ontology:DOID:2058); brain ischemia (Disease Ontology:DOID:2316); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); abdominal aortic aneurysm (Disease Ontology:DOID:7693); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:26419); (R-MMU-111446); (R-MMU-139910); (R-MMU-193648); (R-MMU-2559580); (R-MMU-2871796); (R-MMU-450321); (R-MMU-450341); (R-MMU-5693565); (R-MMU-9007892)", "pathway_count": 10, "publication_count": 57, "publication_id_list": "10523642;10811224;11562351;11602244;12391307;14499478;15345747;16061178;16166642;16504051;16618812;17709198;17761173;19696185;19966288;20070884;21297631;21447485;21479164;21750661;22441692;22539006;23667647;23963642;24733548;24976766;25381390;25428506;25605945;27084103;27959936;28632169;28874678;28943315;29085990;29153991;29323338;29433422;30084848;30210577;30779550;30853885;31219806;31419957;31482248;32456175;33128669;33428096;34428180;35111058;35370650;35940125;36283086;36812915;9096336;9207092;9393873", "class_list": "", "function": "Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity., [UniProtKB, UniProtKB, UniProtKB]; Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death (PubMed:28943315, PubMed:9393873). Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity (PubMed:11602244). Phosphorylates the replication licensing factor CDT1, inhibiting the interaction between CDT1 and the histone H4 acetylase HBO1 to replication origins. Loss of this interaction abrogates the acetylation required for replication initiation. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including p53/TP53 and Yes-associates protein YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells (PubMed:10811224). Contributes to the survival of erythroid cells by phosphorylating the antagonist of cell death BAD upon EPO stimulation (By similarity). Mediates starvation-induced BCL2 phosphorylation, BCL2 dissociation from BECN1, and thus activation of autophagy (PubMed:36812915). Phosphorylates STMN2 and hence regulates microtubule dynamics, controlling neurite elongation in cortical neurons (PubMed:21297631). In the developing brain, through its cytoplasmic activity on STMN2, negatively regulates the rate of exit from multipolar stage and of radial migration from the ventricular zone (PubMed:21297631). Phosphorylates several other substrates including heat shock factor protein 4 (HSF4), the deacetylase SIRT1, ELK1, or the E3 ligase ITCH. Phosphorylates the CLOCK-BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692). Phosphorylates the heat shock transcription factor HSF1, suppressing HSF1-induced transcriptional activity (By similarity). Phosphorylates POU5F1, which results in the inhibition of POU5F1's transcriptional activity and enhances its proteasomal degradation (PubMed:29153991). Phosphorylates JUND and this phosphorylation is inhibited in the presence of MEN1 (By similarity). In neurons, phosphorylates SYT4 which captures neuronal dense core vesicles at synapses (By similarity). Phosphorylates EIF4ENIF1/4-ET in response to oxidative stress, promoting P-body assembly (By similarity). Phosphorylates SIRT6 in response to oxidative stress, stimulating its mono-ADP-ribosyltransferase activity (By similarity). Phosphorylates NLRP3, promoting assembly of the NLRP3 inflammasome (PubMed:28943315). Phosphorylates ALKBH5 in response to reactive oxygen species (ROS), promoting ALKBH5 sumoylation and inactivation (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0042826 histone deacetylase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:1990166 protein localization to site of double-strand break;GO:0007258 JUN phosphorylation;GO:0061833 protein localization to tricellular tight junction;GO:0038127 ERBB signaling pathway;GO:0044546 NLRP3 inflammasome complex assembly", "synthesized_glycan_count": 0, "hit_score": 5.8, "record_id": "Q91Y86-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BVI4-1", "uniprot_id": [ { "id": "DHPR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BVI4", "type": "external" } ], "mass": 25570.0, "length": 241, "protein_name": "Dihydropteridine reductase", "gene_name": "Qdpr", "organism": "Mouse", "refseq_name": "dihydropteridine reductase", "refseq_ac": [ { "id": "NP_077198", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077198", "type": "external" } ], "gene_names_uniprotkb": "Qdpr; Dhpr", "gene_names_refseq": "2610008L04Rik; D5Ertd371e; Dhpr; PKU2; Qdpr", "protein_names_uniprotkb": "Dihydropteridine reductase; 1.5.1.34; HDHPR; Quinoid dihydropteridine reductase", "protein_names_refseq": "HDHPR; dihydropteridine reductase", "tax_id": 10090, "disease": "BH4-deficient hyperphenylalaninemia C (Disease Ontology:DOID:0081130); hypertension (Disease Ontology:DOID:10763); status epilepticus (Disease Ontology:DOID:1824); phenylketonuria (Disease Ontology:DOID:9281)", "pathway": " (mmu:110391); (R-MMU-8964208)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "21750661;22020936;23806337;25240194;26740625;34428180;36184122;37453647;37507081;39927985", "class_list": "", "function": "Catalyzes the conversion of quinonoid dihydrobiopterin into tetrahydrobiopterin., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; JP1 and JP2 can facilitate the assembly of DHPR with other proteins of the excitation-contraction coupling machinery, [RefSeq, PubMed]; Quinonoid dihydropteridine reductase, a tetrahydrobiopterin-recycling enzyme, contributes to 5-hydroxytryptamine-associated platelet aggregation in mice., [RefSeq, PubMed]; Wide alterations in folate-associated metabolism in the Qdpr(-/-) mice, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TT09;Q9D0K4", "ec_number_list": [ { "id": "1.5.1.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.34", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0070402 NADPH binding;GO:0004155 6,7-dihydropteridine reductase activity;GO:0070404 NADH binding;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006559 L-phenylalanine catabolic process;GO:0006729 tetrahydrobiopterin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8BVI4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97863-1", "uniprot_id": [ { "id": "NFIB_MOUSE", "url": "https://www.uniprot.org/uniprot/P97863", "type": "external" } ], "mass": 63507.0, "length": 570, "protein_name": "Nuclear factor 1 B-type", "gene_name": "Nfib", "organism": "Mouse", "refseq_name": "nuclear factor 1 B-type isoform 1", "refseq_ac": [ { "id": "NP_001106680", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106680", "type": "external" } ], "gene_names_uniprotkb": "Nfib", "gene_names_refseq": "6720429L07Rik; CTF; E030026I10Rik; NF-I/B; NF1-B; NFI-B; Nfib", "protein_names_uniprotkb": "Nuclear factor 1 B-type; CCAAT-box-binding transcription factor; CTF; NF-I/B; NF1-B; NFI-B; Nuclear factor 1/B; Nuclear factor I/B; TGGCA-binding protein", "protein_names_refseq": "CCAAT-box-binding transcription factor; TGGCA-binding protein; nuclear factor 1 B-type isoform 1; nuclear factor 1 B-type; nuclear factor 1/B", "tax_id": 10090, "disease": "", "pathway": " (mmu:18028)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10087299;12568726;15345747;15632069;17242355;21183079;21750661;23806337;24129315;25428506;30084848;30388402;30779550;31219806;31599954;34428180;40885482;40997131;9056636", "class_list": "", "function": "Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Transcriptional activator of GFAP, essential for proper brain development (PubMed:15632069, PubMed:30388402). Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication (PubMed:30388402)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P70252;P70253;P70254;Q9R1G4", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003690 double-stranded DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0001650 fibrillar center;GO:0044300 cerebellar mossy fiber", "go_biological_process": "GO:0031099 regeneration;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P97863-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UZ39-1", "uniprot_id": [ { "id": "LRRF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UZ39", "type": "external" } ], "mass": 79249.0, "length": 729, "protein_name": "Leucine-rich repeat flightless-interacting protein 1", "gene_name": "Lrrfip1", "organism": "Mouse", "refseq_name": "leucine-rich repeat flightless-interacting protein 1 isoform 1", "refseq_ac": [ { "id": "NP_001104781", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104781", "type": "external" } ], "gene_names_uniprotkb": "Lrrfip1; Flap", "gene_names_refseq": "Fliiap1; Lrrfip1", "protein_names_uniprotkb": "Leucine-rich repeat flightless-interacting protein 1; FLI-LRR-associated protein 1; Flap-1; H186 FLAP; LRR FLII-interacting protein 1", "protein_names_refseq": "FLAP (FLI LRR associated protein); FLI-LRR-associated protein 1; H186 FLAP; LRR FLII-interacting protein 1; flap-1; leucine-rich repeat flightless-interacting protein 1 isoform 1; leucine-rich repeat flightless-interacting protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:16978)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;17242355;20453844;21183079;21750661;22645316;24788674;25153642;26495903;28135057;28528544;31219806;34428180;34887587;9525888", "class_list": "", "function": "LRRFIP1 and its downstream partner beta-catenin constitute another coactivator pathway for IRF3-mediated production of type I interferon, [RefSeq, PubMed]; Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA (By similarity). Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O70323;Q3TS94", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0042803 protein homodimerization activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q3UZ39-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CRD4-1", "uniprot_id": [ { "id": "DBND2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CRD4", "type": "external" } ], "mass": 17194.0, "length": 158, "protein_name": "Dysbindin domain-containing protein 2", "gene_name": "Dbndd2", "organism": "Mouse", "refseq_name": "dysbindin domain-containing protein 2", "refseq_ac": [ { "id": "NP_001041692", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041692", "type": "external" } ], "gene_names_uniprotkb": "Dbndd2; D2Bwg0891e", "gene_names_refseq": "1110017A21Rik; 2900022J10Rik; D2Bwg0891e; Dbndd2; Nkip; R74724", "protein_names_uniprotkb": "Dysbindin domain-containing protein 2", "protein_names_refseq": "SCF apoptosis response protein 1; dysbindin (dystrobrevin binding protein 1) domain containing 2; dysbindin domain-containing protein 2; likely orthologue of H. sapiens chromosome 20 open reading frame 35", "tax_id": 10090, "disease": "", "pathway": " (mmu:52840)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "18096156;21183079;21750661;25297099;25428506;30084848;34428180;35820727", "class_list": "", "function": "May modulate the activity of casein kinase-1. Inhibits CSNK1D autophosphorylation (in vitro) (By similarity)., [UniProtKB]; These findings reveal the essential roles of dysbindin and CaMKIIalpha in the stabilization of dendritic protrusions, [RefSeq, PubMed]; Thus, we have identified NKIP as an important novel protein that interacts to the NKA complex, influencing cellular ion balance, induction of apoptosis and neuronal differentiation.(NKIP PROTEIN, MOUSE), [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051117 ATPase binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005764 lysosome;GO:0005737 cytoplasm", "go_biological_process": "GO:0031175 neuron projection development;GO:0006469 negative regulation of protein kinase activity;GO:0006915 apoptotic process;GO:0050790 regulation of catalytic activity;GO:0070371 ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9CRD4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26443-1", "uniprot_id": [ { "id": "DHE3_MOUSE", "url": "https://www.uniprot.org/uniprot/P26443", "type": "external" } ], "mass": 61337.0, "length": 558, "protein_name": "Glutamate dehydrogenase 1, mitochondrial", "gene_name": "Glud1", "organism": "Mouse", "refseq_name": "glutamate dehydrogenase 1, mitochondrial precursor", "refseq_ac": [ { "id": "NP_032159", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032159", "type": "external" } ], "gene_names_uniprotkb": "Glud1; Glud", "gene_names_refseq": "Gdh-X; Glud1; Gludl; Glud", "protein_names_uniprotkb": "Glutamate dehydrogenase 1, mitochondrial; 1.4.1.3; GDH 1", "protein_names_refseq": "GDH 1; glutamate dehydrogenase 1, mitochondrial precursor; glutamate dehydrogenase 1, mitochondrial", "tax_id": 10090, "disease": "familial hyperinsulinemic hypoglycemia 6 (Disease Ontology:DOID:0070217); Alzheimer's disease (Disease Ontology:DOID:10652); hepatic encephalopathy (Disease Ontology:DOID:13413); childhood absence epilepsy (Disease Ontology:DOID:1825); hyperinsulinism (Disease Ontology:DOID:2018); brain ischemia (Disease Ontology:DOID:2316); temporal lobe epilepsy (Disease Ontology:DOID:3328); fascioliasis (Disease Ontology:DOID:885); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (mmu:14661); (R-MMU-2151201); (R-MMU-8964539); (R-MMU-9837999)", "pathway_count": 4, "publication_count": 21, "publication_id_list": "10.1101/2023.09.13.557529;16959573;1711373;17242355;18034455;20670938;21183079;21750661;23576753;23663782;23806337;26740625;34105348;34428180;35820727;36288343;37453647;37507081;38060673;38124277;39927985", "class_list": "", "function": "GluD1 binds GABA and controls inhibitory plasticity., [RefSeq, PubMed]; Increases in anterograde axoplasmic transport in neurons of the hyper-glutamatergic, glutamate dehydrogenase 1 (Glud1) transgenic mouse: Effects of glutamate receptors on transport., [RefSeq, PubMed]; Mitochondrial glutamate dehydrogenase that converts L-glutamate into alpha-ketoglutarate (PubMed:20670938). Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (By similarity). Plays a role in insulin homeostasis (PubMed:16959573). May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 9, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8C273", "ec_number_list": [ { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "1.15.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.15.1.1", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.286", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.286", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.1.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.38", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.1", "type": "external" }, { "id": "6.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.17", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0019899 enzyme binding;GO:0042803 protein homodimerization activity;GO:0043531 ADP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0032024 positive regulation of insulin secretion;GO:0010044 response to aluminum ion;GO:0006541 glutamine metabolic process;GO:0006538 L-glutamate catabolic process;GO:0072350 tricarboxylic acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P26443-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08788-1", "uniprot_id": [ { "id": "DCTN1_MOUSE", "url": "https://www.uniprot.org/uniprot/O08788", "type": "external" } ], "mass": 141676.0, "length": 1281, "protein_name": "Dynactin subunit 1", "gene_name": "Dctn1", "organism": "Mouse", "refseq_name": "dynactin subunit 1 isoform 1", "refseq_ac": [ { "id": "NP_031861", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031861", "type": "external" } ], "gene_names_uniprotkb": "Dctn1", "gene_names_refseq": "DAP-150; DP-150; Dctn1; Glued; p150-glued; p150; p150", "protein_names_uniprotkb": "Dynactin subunit 1; 150 kDa dynein-associated polypeptide; DAP-150; DP-150; p150-glued", "protein_names_refseq": "150 kDa dynein-associated polypeptide; dynactin 1, retrograde axonal transport; dynactin subunit 1 isoform 1; dynactin subunit 1", "tax_id": 10090, "disease": "synucleinopathy (Disease Ontology:DOID:0050890); amyotrophic lateral sclerosis type 1 (Disease Ontology:DOID:0060193); Perry syndrome (Disease Ontology:DOID:0060486); autosomal dominant distal hereditary motor neuronopathy 14 (Disease Ontology:DOID:0111202); motor neuron disease (Disease Ontology:DOID:231); amyotrophic lateral sclerosis (Disease Ontology:DOID:332)", "pathway": " (mmu:13191); (R-MMU-2132295); (R-MMU-2565942); (R-MMU-3371497); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-5620912); (R-MMU-6807878); (R-MMU-6811436); (R-MMU-8854518)", "pathway_count": 12, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;14581450;16954346;19935774;21750661;22275436;22645316;22956769;23386061;25189619;27474409;30787442;33300544;34428180;36852467;37507081;39627609;40885482;9070275", "class_list": "", "function": "Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule. Can regulate microtubule stability by promoting microtubule formation, nucleation and polymerization and by inhibiting microtubule catastrophe in neurons. Inhibits microtubule catastrophe by binding both to microtubules and to tubulin, leading to enhanced microtubule stability along the axon. Plays a role in metaphase spindle orientation. Plays a role in centriole cohesion and subdistal appendage organization and function. Its recruitment to the centriole in a KIF3A-dependent manner is essential for the maintenance of centriole cohesion and the formation of subdistal appendage. Also required for microtubule anchoring at the mother centriole. Plays a role in primary cilia formation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 6, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "E9QLJ1;Q3TZG7", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0008017 microtubule binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0015631 tubulin binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005819 spindle", "go_biological_process": "GO:0007077 mitotic nuclear membrane disassembly;GO:0007528 neuromuscular junction development;GO:0050905 neuromuscular process;GO:0051301 cell division;GO:0070050 neuron cellular homeostasis", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "O08788-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q501J6-1", "uniprot_id": [ { "id": "DDX17_MOUSE", "url": "https://www.uniprot.org/uniprot/Q501J6", "type": "external" } ], "mass": 72399.0, "length": 650, "protein_name": "Probable ATP-dependent RNA helicase DDX17", "gene_name": "Ddx17", "organism": "Mouse", "refseq_name": "probable ATP-dependent RNA helicase DDX17 isoform 4", "refseq_ac": [ { "id": "NP_001035277", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035277", "type": "external" } ], "gene_names_uniprotkb": "Ddx17", "gene_names_refseq": "2610007K22Rik; A430025E01Rik; Ddx17; Gm926; p72", "protein_names_uniprotkb": "Probable ATP-dependent RNA helicase DDX17; 3.6.4.13; DEAD box protein 17", "protein_names_refseq": "DEAD (Asp-Glu-Ala-Asp) box polypeptide 17; DEAD box protein 17; probable ATP-dependent RNA helicase DDX17 isoform 4; probable ATP-dependent RNA helicase DDX17", "tax_id": 10090, "disease": "abdominal obesity-metabolic syndrome (Disease Ontology:DOID:0060611); alcohol use disorder (Disease Ontology:DOID:1574); cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:67040); (R-MMU-3899300)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "17011493;20173027;22266867;22645316;23022728;24129315;24788674;25153642;25428506;26947125;28528544;31219806;34428180;34860583;34887587;35820727;37453647;37828378;38782919", "class_list": "", "function": "As an RNA helicase, unwinds RNA and alters RNA structures through ATP binding and hydrolysis. Involved in multiple cellular processes, including pre-mRNA splicing, alternative splicing, ribosomal RNA processing and miRNA processing, as well as transcription regulation. Regulates the alternative splicing of exons exhibiting specific features. This function requires the RNA helicase activity. Affects NFAT5 and histone macro-H2A.1/MACROH2A1 alternative splicing in a CDK9-dependent manner. Affects splicing of mediators of steroid hormone signaling pathway, including kinases that phosphorylates ESR1 and transcriptional regulators. By acting splicing of regulatory factors, participates in ESR1 and AR stabilization. Promotes the inclusion of specific AC-rich alternative exons in CD44 transcripts. In myoblasts and epithelial cells, cooperates with HNRNPH1 to control the splicing of specific subsets of exons. In addition to binding mature mRNAs, also interacts with certain pri-microRNAs, including MIR132/miR-132, and stabilizes the primary transcript. Also participates in the MIR132 processing, resulting in significantly higher levels of mature MIR132 than MIR212 despite the fact that both are cotranscribed and co-regulated (PubMed:26947125). Binding of pri-microRNAs may occur on the 3' segment flanking the stem loop via the 5'-[ACG]CAUC[ACU]-3' consensus sequence (By similarity). Participates in MYC down-regulation at high cell density through the production of MYC-targeting microRNAs. Along with DDX5, may be involved in the processing of the 32S intermediate into the mature 28S rRNA. Promoter-specific transcription regulator, functioning as a coactivator or corepressor depending on the context of the promoter and the transcriptional complex in which it exists. Enhances NFAT5 transcriptional activity. Synergizes with TP53 in the activation of the MDM2 promoter; this activity requires acetylation on lysine residues. May also coactivate MDM2 transcription through a TP53-independent pathway. Coactivates MMP7 transcription. Along with CTNNB1, coactivates MYC, JUN, FOSL1 and cyclin D1/CCND1 transcription. Alone or in combination with DDX5 and/or SRA1 non-coding RNA, plays a critical role in promoting the assembly of proteins required for the formation of the transcription initiation complex and chromatin remodeling leading to coactivation of MYOD1-dependent transcription. This helicase-independent activity is required for skeletal muscle cells to properly differentiate into myotubes (PubMed:17011493). During epithelial-to-mesenchymal transition, coregulates SMAD-dependent transcriptional activity, directly controlling key effectors of differentiation, including miRNAs which in turn directly repress its expression. Plays a role in estrogen and testosterone signaling pathway at several levels. Mediates the use of alternative promoters in estrogen-responsive genes and regulates transcription and splicing of a large number of steroid hormone target genes. Contrary to the splicing regulation activity, transcriptional coregulation of the estrogen receptor ESR1 is helicase activity-independent. Plays a role in innate immunity. Specifically restricts bunyavirus infection, including Rift Valley fever virus (RVFV) or La Crosse virus (LACV), but not vesicular stomatitis virus (VSV), in an interferon- and DROSHA-independent manner. Binds to RVFV RNA, likely via structured viral RNA elements (By similarity). Promotes mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1, in an ATPase-dependent manner (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; DDX17 is an essential mediator of sterile NLRC4 inflammasome activation by retrotransposon RNAs., [RefSeq, PubMed]; DEAD-box helicase 17 (DDX17) protects cardiac function by promoting mitochondrial homeostasis in heart failure. Publication Status: Online-Only, [RefSeq, PubMed]; Data indicate that transcriptional coregulator ddx5/ddx17 RNA helicases can simultaneously regulate the transcriptional activity and alternative splicing of NFAT5 transcription factor., [RefSeq, PubMed]; This gene encodes the mouse homolog of human DEAD box polypeptide 17. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD). RNA helicases of the DEAD-box family are involved in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and splicesosome assembly. Alternative splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P5G1;Q8BIN2", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0031490 chromatin DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051607 defense response to virus;GO:0001837 epithelial to mesenchymal transition;GO:0010586 miRNA metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q501J6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64442-1", "uniprot_id": [ { "id": "DHSO_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64442", "type": "external" } ], "mass": 38249.0, "length": 357, "protein_name": "Sorbitol dehydrogenase", "gene_name": "Sord", "organism": "Mouse", "refseq_name": "sorbitol dehydrogenase", "refseq_ac": [ { "id": "NP_666238", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666238", "type": "external" } ], "gene_names_uniprotkb": "Sord; Sdh1", "gene_names_refseq": "SDH; Sdh-1; Sdh1; Sodh-1; Sord; XDH", "protein_names_uniprotkb": "Sorbitol dehydrogenase; 1.1.1.-; 1.1.1.14; 1.1.1.9; L-iditol 2-dehydrogenase; Polyol dehydrogenase; SDH; SORD; XDH; Xylitol dehydrogenase", "protein_names_refseq": "L-iditol 2-dehydrogenase; polyol dehydrogenase; sorbitol dehydrogenase 1; sorbitol dehydrogenase; xylitol dehydrogenase", "tax_id": 10090, "disease": "autosomal recessive distal hereditary motor neuronopathy 8 (Disease Ontology:DOID:0081427); cataract (Disease Ontology:DOID:83); diabetic neuropathy (Disease Ontology:DOID:9743)", "pathway": " (mmu:20322); (R-MMU-5652227); (R-MMU-5661270)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "18630941;18799757;26647419;28422384;34428180;37453647;40885482;6852349;7601136", "class_list": "glycogene", "function": "Flavonoids induced marked improvement in paw licking time, paw edema %, malondialdehyde content, superoxide dismutase, and sorbitol dehydrogenase activities, with slight progress in paw interlukin-1beta. Additionally, silymarin augmented brain content of dopamine and norepinephrine., [RefSeq, PubMed]; Nicotine-induced reduced expression of Sord could be involved in impaired secretory functions of the epididymis., [RefSeq, PubMed]; Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols (By similarity). Is active with D-sorbitol (D-glucitol) leading to the C2-oxidized product D-fructose (PubMed:6852349). Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism (By similarity). May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility and protein tyrosine phosphorylation (PubMed:18799757). Has no activity on ethanol. Cannot use NADP(+) as the electron acceptor (PubMed:6852349)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 17, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q569V5;Q9CPS0", "ec_number_list": [ { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.14", "type": "external" }, { "id": "1.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.9", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0051287 NAD binding;GO:0003939 L-iditol 2-dehydrogenase (NAD+) activity;GO:0046526 D-xylulose reductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0016020 membrane;GO:0031514 motile cilium;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0006060 sorbitol metabolic process;GO:0030317 flagellated sperm motility;GO:0046686 response to cadmium ion;GO:0009725 response to hormone;GO:0046688 response to copper ion", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q64442-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000001.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80TQ2-1", "uniprot_id": [ { "id": "CYLD_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80TQ2", "type": "external" } ], "mass": 106586.0, "length": 952, "protein_name": "Ubiquitin carboxyl-terminal hydrolase CYLD", "gene_name": "Cyld", "organism": "Mouse", "refseq_name": "ubiquitin carboxyl-terminal hydrolase CYLD isoform a", "refseq_ac": [ { "id": "NP_001121642", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121642", "type": "external" } ], "gene_names_uniprotkb": "Cyld; Cyld1; Kiaa0849", "gene_names_refseq": "2010013M14Rik; 2900009M21Rik; C130039D01Rik; CDMT; CYLD1; Cyld; EAC; mKIAA0849", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase CYLD; 3.4.19.12; Deubiquitinating enzyme CYLD; Ubiquitin thioesterase CYLD; Ubiquitin-specific-processing protease CYLD", "protein_names_refseq": "cylindromatosis (turban tumor syndrome); deubiquitinating enzyme CYLD; ubiquitin carboxyl-terminal hydrolase CYLD isoform a; ubiquitin carboxyl-terminal hydrolase CYLD; ubiquitin thioesterase CYLD; ubiquitin thiolesterase CYLD; ubiquitin-specific-processing protease CYLD", "tax_id": 10090, "disease": "Brooke-Spiegler syndrome (Disease Ontology:DOID:0050693); multiple familial trichoepithelioma 1 (Disease Ontology:DOID:0061187)", "pathway": " (mmu:74256); (R-MMU-168638); (R-MMU-5357786); (R-MMU-5357905); (R-MMU-5357956); (R-MMU-5689880); (R-MMU-936440)", "pathway_count": 7, "publication_count": 23, "publication_id_list": "10.1101/2023.09.13.557529;15226292;16501569;16713561;17053834;17392286;17548520;18382763;18643924;19893491;20194890;21183079;25134987;28701375;29291351;30016717;31599954;32185393;32424362;33300544;34428180;38561786;38677721", "class_list": "", "function": "A critical role for CYLD in regulating the basal activity of NF-kappaB and maintaining the naive phenotype and proper activation of B cells., [RefSeq, PubMed]; CYLD alleviates NLRP3 inflammasome-mediated pyroptosis in osteoporosis by deubiquitinating WNK1. Publication Status: Online-Only, [RefSeq, PubMed]; CYLD is induced by NF-kappaB, [RefSeq, PubMed]; CYLD limits inflammation and tumorigenesis by regulating ubiquitination in vivo, [RefSeq, PubMed]; Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-induced necroptosis (PubMed:17548520, PubMed:28701375, PubMed:29291351, PubMed:32185393, PubMed:32424362). Negatively regulates NF-kappa-B activation by deubiquitinating upstream signaling factors (PubMed:16713561). Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation (PubMed:16713561). Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules (PubMed:19893491). Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis (PubMed:16713561, PubMed:19893491, PubMed:20194890). Required for normal cell cycle progress and normal cytokinesis (PubMed:19893491). Inhibits nuclear translocation of NF-kappa-B (By similarity). Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation (By similarity). Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells (PubMed:16501569, PubMed:18643924). Negatively regulates TNFRSF11A signaling and osteoclastogenesis (PubMed:18382763). Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane; this process does not depend on NF-kappa-B activation (PubMed:25134987). Ability to remove linear ('Met-1'-linked) polyubiquitin chains regulates innate immunity and TNF-induced necroptosis: recruited to the LUBAC complex via interaction with SPATA2 and restricts linear polyubiquitin formation on target proteins (PubMed:28701375). Regulates innate immunity by restricting linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation (By similarity). Involved in TNF-induced necroptosis by removing linear ('Met-1'-linked) polyubiquitin chains from RIPK1, thereby regulating the kinase activity of RIPK1 (PubMed:28701375). Negatively regulates intestinal inflammation by removing 'Lys-63' linked polyubiquitin chain of NLRP6, thereby reducing the interaction between NLRP6 and PYCARD/ASC and formation of the NLRP6 inflammasome (PubMed:32424362). Does not catalyze deubiquitination of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains (By similarity). Removes 'Lys-63' linked polyubiquitin chain of MAP3K7, which inhibits phosphorylation and blocks downstream activation of the JNK-p38 kinase cascades (PubMed:17548520, PubMed:29291351). Also removes 'Lys-63'-linked polyubiquitin chains of MAP3K1 and MA3P3K3, which inhibit their interaction with MAP2K1 and MAP2K2 (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Identifed CYLD as a positive regulator of proximal T cell receptor signaling in thymocytes, [RefSeq, PubMed]; Inactivation of the Tumor Suppressor CYLD Sensitizes Mice to Breast Cancer Development., [RefSeq, PubMed]; These data indicate that, depending on the external signals, Cyld can negatively regulate different NF-kappaB pathways; inactivation of TRAF2 controls survival and inflammation, while inhibition of Bcl-3 controls proliferation and tumor growth., [RefSeq, PubMed]; This gene encodes a protein that is a member of the ubiquitin C-terminal hydrolase subfamily of the deubiquitinating enzyme family. Members of this family catalyze the removal of ubiquitin from a substrate or another ubiquitin molecule and thereby play important roles in regulating signaling pathways, recycling ubiquitin and regulating protein stability. This protein removes ubiquitin from K-63-linked ubiquitin chains from proteins involved in NF-kappaB signaling and thus acts as a negative regulator of this pathway. In humans mutations in this gene have been associated with cylindromatosis, an autosomal dominant predisposition to tumors of skin appendages. In mouse deficiency of this gene impairs thymocyte development and increases susceptibility to skin and colon tumors. A pseudogene of this gene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A0A1B0GSE5;Q3TJI3;Q80VB3;Q8BXZ3;Q8BYL9;Q8CGB0", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019901 protein kinase binding;GO:0070064 proline-rich region binding;GO:0004843 cysteine-type deubiquitinase activity;GO:0061578 K63-linked deubiquitinase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005819 spindle;GO:0005829 cytosol", "go_biological_process": "GO:0045577 regulation of B cell differentiation;GO:0043369 CD4-positive or CD8-positive, alpha-beta T cell lineage commitment;GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q80TQ2-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80TR8-1", "uniprot_id": [ { "id": "DCAF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80TR8", "type": "external" } ], "mass": 168931.0, "length": 1506, "protein_name": "DDB1- and CUL4-associated factor 1", "gene_name": "Dcaf1", "organism": "Mouse", "refseq_name": "DDB1- and CUL4-associated factor 1 isoform 3", "refseq_ac": [ { "id": "NP_001015507", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015507", "type": "external" } ], "gene_names_uniprotkb": "Dcaf1; Kiaa0800; Vprbp", "gene_names_refseq": "B930007L02Rik; Dcaf1; Vprbp; mKIAA0800", "protein_names_uniprotkb": "DDB1- and CUL4-associated factor 1; 2.7.11.1; Serine/threonine-protein kinase VPRBP", "protein_names_refseq": "DDB1- and CUL4-associated factor 1 isoform 3; Vpr (HIV-1) binding protein; protein VPRBP; serine/threonine-protein kinase VPRBP", "tax_id": 10090, "disease": "", "pathway": " (mmu:321006); (R-MMU-983168)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;11223251;18606781;21750661;22157821;23806337;24357321;25428506;25557551;30016717;30084848;31219806;32782141;34428180;36056023;39627609", "class_list": "", "function": "Acts both as a substrate recognition component of E3 ubiquitin-protein ligase complexes and as an atypical serine/threonine-protein kinase, playing key roles in various processes such as cell cycle, telomerase regulation and histone modification (By similarity). Probable substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, named CUL4A-RBX1-DDB1-DCAF1/VPRBP complex, which mediates ubiquitination and proteasome-dependent degradation of proteins such as NF2 (By similarity). Involved in the turnover of methylated proteins: recognizes and binds methylated proteins via its chromo domain, leading to ubiquitination of target proteins by the RBX1-DDB1-DCAF1/VPRBP complex (By similarity). The CUL4A-RBX1-DDB1-DCAF1/VPRBP complex is also involved in B-cell development: DCAF1 is recruited by RAG1 to ubiquitinate proteins, leading to limit error-prone repair during V(D)J recombination (PubMed:22157821). Also part of the EDVP complex, an E3 ligase complex that mediates ubiquitination of proteins such as TERT, leading to TERT degradation and telomerase inhibition (By similarity). The EDVP complex also mediates ubiquitination and degradation of CCP110 (By similarity). Also acts as an atypical serine/threonine-protein kinase that specifically mediates phosphorylation of 'Thr-120' of histone H2A (H2AT120ph) in a nucleosomal context, thereby repressing transcription (By similarity). H2AT120ph is present in the regulatory region of many tumor suppresor genes, down-regulates their transcription and is present at high level in a number of tumors (By similarity). Involved in JNK-mediated apoptosis during cell competition process via its interaction with LLGL1 and LLGL2 (By similarity). By acting on TET dioxygenses, essential for oocyte maintenance at the primordial follicle stage, hence essential for female fertility (PubMed:24357321)., [UniProtKB, UniProtKB, PubMed, PubMed]; Data show that human immunodeficiency virus type 1 Vpr-binding protein VprBP binds stoichiometrically with DDB1 through its WD40 domain and through DDB1 to CUL4A, subunits of the COP9/signalsome., [RefSeq, PubMed]; Multi-subunit cullin RING E3 ligase complex VprBP/DDB1/Cul4A/Roc1 associates with full-length RAG1 through VprBP, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q3UXD5;Q6P1E2;Q8CDY3", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0030331 nuclear estrogen receptor binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity;GO:1990244 histone H2AT120 kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0031464 Cul4A-RING E3 ubiquitin ligase complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0043687 post-translational protein modification;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q80TR8-1", "record_type": "protein", "filter_code": "0000000.1100101.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K0T2-1", "uniprot_id": [ { "id": "DC2L1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K0T2", "type": "external" } ], "mass": 39469.0, "length": 351, "protein_name": "Cytoplasmic dynein 2 light intermediate chain 1", "gene_name": "Dync2li1", "organism": "Mouse", "refseq_name": "cytoplasmic dynein 2 light intermediate chain 1", "refseq_ac": [ { "id": "NP_758460", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_758460", "type": "external" } ], "gene_names_uniprotkb": "Dync2li1; D2lic", "gene_names_refseq": "4933404O11Rik; CGI-60; D2lic; Dync2li1; LIC3; mD2LIC", "protein_names_uniprotkb": "Cytoplasmic dynein 2 light intermediate chain 1; mD2LIC", "protein_names_refseq": "cytoplasmic dynein 2 light intermediate chain 1; dynein 2 light intermediate chain", "tax_id": 10090, "disease": "asphyxiating thoracic dystrophy (Disease Ontology:DOID:0050592)", "pathway": " (mmu:213575); (R-MMU-5620924)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "11907264;12432068;12802074;15371312", "class_list": "", "function": "Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system, facilitating the assembly of these organelles (By similarity) (PubMed:15371312). Involved in the regulation of ciliary length (By similarity)., [UniProtKB, UniProtKB, PubMed]; Required to maintain or establish ventral cell fates and for correct signalling by the organiser and midline, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TVA2", "ec_number_list": [], "go_molecular_function": "GO:0045504 dynein heavy chain binding", "go_cellular_component": "GO:0097227 sperm annulus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005874 microtubule", "go_biological_process": "GO:0060271 cilium assembly;GO:0007368 determination of left/right symmetry;GO:0035735 intraciliary transport involved in cilium assembly;GO:1902017 regulation of cilium assembly;GO:0035721 intraciliary retrograde transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8K0T2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D2H9-1", "uniprot_id": [ { "id": "DAAF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D2H9", "type": "external" } ], "mass": 69704.0, "length": 634, "protein_name": "Dynein axonemal assembly factor 1", "gene_name": "Dnaaf1", "organism": "Mouse", "refseq_name": "dynein axonemal assembly factor 1", "refseq_ac": [ { "id": "NP_080924", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080924", "type": "external" } ], "gene_names_uniprotkb": "Dnaaf1; Lrrc50", "gene_names_refseq": "4930457P18Rik; Dnaaf1; Lrrc50; m4Bei", "protein_names_uniprotkb": "Dynein axonemal assembly factor 1; Leucine-rich repeat-containing protein 50", "protein_names_refseq": "dynein assembly factor 1, axonemal; dynein axonemal assembly factor 1; leucine-rich repeat-containing protein 50", "tax_id": 10090, "disease": "idiopathic scoliosis (Disease Ontology:DOID:0060250); primary ciliary dyskinesia 13 (Disease Ontology:DOID:0110618); seminoma (Disease Ontology:DOID:4440); testicular germ cell cancer (Disease Ontology:DOID:5557); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898)", "pathway": " (mmu:68270)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;19944400;21183079;27261005", "class_list": "", "function": "Cilium-specific protein required for the stability of the ciliary architecture. Plays a role in cytoplasmic preassembly of dynein arms (By similarity). Involved in regulation of microtubule-based cilia and actin-based brush border microvilli (By similarity)., [UniProtKB]; LRRC50 plays a role in assembly of distinct dynein-arm complexes, [RefSeq, PubMed]; Mutations in Dnaaf1 cause hydrocephalus, laterality defects, and sinusitis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9CVS9", "ec_number_list": [], "go_molecular_function": "GO:0070840 dynein complex binding", "go_cellular_component": "GO:0005930 axoneme", "go_biological_process": "GO:0060972 left/right pattern formation;GO:0030324 lung development;GO:0060271 cilium assembly;GO:0007368 determination of left/right symmetry;GO:0001947 heart looping", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9D2H9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DID5-1", "uniprot_id": [ { "id": "PWP3A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6DID5", "type": "external" } ], "mass": 76069.0, "length": 682, "protein_name": "PWWP domain-containing DNA repair factor 3A", "gene_name": "Pwwp3a", "organism": "Mouse", "refseq_name": "PWWP domain-containing DNA repair factor 3A", "refseq_ac": [ { "id": "NP_075920", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075920", "type": "external" } ], "gene_names_uniprotkb": "Pwwp3a; Mum1", "gene_names_refseq": "2610019J09; 9430059D04Rik; MUM-1; Mum1; Pwwp3a; UBE-1C2", "protein_names_uniprotkb": "PWWP domain-containing DNA repair factor 3A; MUM-1; Mutated melanoma-associated antigen 1; PWWP domain-containing protein MUM1; PWWP3A", "protein_names_refseq": "PWWP domain-containing DNA repair factor 3A; PWWP domain-containing protein MUM1; melanoma associated antigen (mutated) 1; mutated melanoma-associated antigen 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:68114)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21183079;21750661;34428180", "class_list": "", "function": "Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TCZ4;Q6NST9;Q8C5E3;Q8R1V6;Q9R1R7", "ec_number_list": [], "go_molecular_function": "GO:0031491 nucleosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006281 DNA repair;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6DID5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D6Y7-1", "uniprot_id": [ { "id": "MSRA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D6Y7", "type": "external" } ], "mass": 25988.0, "length": 233, "protein_name": "Mitochondrial peptide methionine sulfoxide reductase", "gene_name": "Msra", "organism": "Mouse", "refseq_name": "mitochondrial peptide methionine sulfoxide reductase isoform 1", "refseq_ac": [ { "id": "NP_001240641", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240641", "type": "external" } ], "gene_names_uniprotkb": "Msra", "gene_names_refseq": "2310045J23Rik; 6530413P12Rik; MSR-A; Msra", "protein_names_uniprotkb": "Mitochondrial peptide methionine sulfoxide reductase; 1.8.4.11; PMSR; Peptide Met(O) reductase; Peptide-methionine (S)-S-oxide reductase; Protein-methionine-S-oxide reductase", "protein_names_refseq": "PMSR; mitochondrial peptide methionine sulfoxide reductase isoform 1; mitochondrial peptide methionine sulfoxide reductase; peptide Met(O) reductase; peptide-methionine (S)-S-oxide reductase; protein-methionine-S-oxide reductase", "tax_id": 10090, "disease": "", "pathway": " (mmu:110265); (R-MMU-5676934)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "12792026;15924425;20368336;21079812;21750661;23576753;23806337;30529269;32308370;34428180;37391679;37453647", "class_list": "", "function": "Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Plays a crucial role in repairing oxidized methionine residues in key lens proteins, such as alpha-crystallin (CRYAA/CRYAB) and cytochrome c (CYCS), thereby restoring their function and maintaining lens transparency., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; MsrA Suppresses Inflammatory Activation of Microglia and Oxidative Stress to Prevent Demyelination via Inhibition of the NOX2-MAPKs/NF-kappaB Signaling Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Msra expression is regulated by (dietary)selenium, [RefSeq, PubMed]; Proper structure-function organization of MsrA plays a role in subcellular distribution of this protein in mouse cells., [RefSeq, PubMed]; Sexually dimorphic effects of methionine sulfoxide reductase A (MsrA) on murine longevity and health span during methionine restriction., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5EBQ7;Q91WK9;Q9DCY2", "ec_number_list": [ { "id": "1.8.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.11", "type": "external" } ], "go_molecular_function": "GO:0008113 peptide-methionine (S)-S-oxide reductase activity;GO:0033744 L-methionine:thioredoxin-disulfide S-oxidoreductase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0034599 cellular response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9D6Y7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGD7-1", "uniprot_id": [ { "id": "NPAS4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGD7", "type": "external" } ], "mass": 87286.0, "length": 802, "protein_name": "Neuronal PAS domain-containing protein 4", "gene_name": "Npas4", "organism": "Mouse", "refseq_name": "neuronal PAS domain-containing protein 4", "refseq_ac": [ { "id": "NP_705781", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_705781", "type": "external" } ], "gene_names_uniprotkb": "Npas4; Nxf", "gene_names_refseq": "LE-PAS; Npas4; Nxf", "protein_names_uniprotkb": "Neuronal PAS domain-containing protein 4; HLH-PAS transcription factor NXF; LE-PAS; Limbic-enhanced PAS protein; Neuronal PAS4", "protein_names_refseq": "HLH-PAS transcription factor NXF; bHLH-PAS type transcription factor NXF; limbic-enhanced PAS protein; neuronal PAS domain-containing protein 4; neuronal PAS4", "tax_id": 10090, "disease": "", "pathway": " (mmu:225872); (R-MMU-9768919)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "14701734;15363889;15380003;18815592;19001414;19284974;21750661;22194569;23029555;23172225;24201284;24291638;24855953;25088421;25549857;25911220;26663079;27189618;27238022;38958450", "class_list": "", "function": "Brain regions differences in amyloid-beta and gene expression in early APP/PS1 mice and identification of Npas4 as a key molecule in Alzheimer's disease. Publication Status: Online-Only, [RefSeq, PubMed]; Identification of transcription factor Npas4, that plays a role in the development of inhibitory synapses by regulating the expression of activity-dependent genes, which in turn control the number of GABA-releasing synapses that form on excitatory neurons, [RefSeq, PubMed]; MRNA expression in the hippocampus 1 h following generalized convulsive seizure, in a pattern which is typical for other activity-dependant genes expressed in this structure., [RefSeq, PubMed]; Transcription factor expressed in neurons of the brain that regulates the excitatory-inhibitory balance within neural circuits and is required for contextual memory in the hippocampus (PubMed:18815592, PubMed:22194569, PubMed:23029555, PubMed:24201284, PubMed:24855953). Plays a key role in the structural and functional plasticity of neurons (PubMed:23172225). Acts as an early-response transcription factor in both excitatory and inhibitory neurons, where it induces distinct but overlapping sets of late-response genes in these two types of neurons, allowing the synapses that form on inhibitory and excitatory neurons to be modified by neuronal activity in a manner specific to their function within a circuit, thereby facilitating appropriate circuit responses to sensory experience (PubMed:24201284, PubMed:24855953). In excitatory neurons, activates transcription of BDNF, which in turn controls the number of GABA-releasing synapses that form on excitatory neurons, thereby promoting an increased number of inhibitory synapses on excitatory neurons (PubMed:18815592, PubMed:22194569, PubMed:24201284). In inhibitory neurons, regulates a distinct set of target genes that serve to increase excitatory input onto somatostatin neurons, probably resulting in enhanced feedback inhibition within cortical circuits (PubMed:24855953). The excitatory and inhibitory balance in neurons affects a number of processes, such as short-term and long-term memory, acquisition of experience, fear memory, response to stress and social behavior (PubMed:18815592, PubMed:22194569, PubMed:23029555, PubMed:24201284, PubMed:27238022). Acts as a regulator of dendritic spine development in olfactory bulb granule cells in a sensory-experience-dependent manner by regulating expression of MDM2 (PubMed:25088421). Efficient DNA binding requires dimerization with another bHLH protein, such as ARNT, ARNT2 or BMAL1 (PubMed:14701734, PubMed:15363889, PubMed:19284974). Can activate the CME (CNS midline enhancer) element (PubMed:14701734, PubMed:15363889)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V3U3", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0044877 protein-containing complex binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0098794 postsynapse;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007612 learning;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q8BGD7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09405-1", "uniprot_id": [ { "id": "NUCL_MOUSE", "url": "https://www.uniprot.org/uniprot/P09405", "type": "external" } ], "mass": 76723.0, "length": 707, "protein_name": "Nucleolin", "gene_name": "Ncl", "organism": "Mouse", "refseq_name": "nucleolin", "refseq_ac": [ { "id": "NP_035010", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035010", "type": "external" } ], "gene_names_uniprotkb": "Ncl; Nuc", "gene_names_refseq": "B530004O11Rik; C23; D0Nds28; D1Nds28; Ncl; Nucleolin; Nucl", "protein_names_uniprotkb": "Nucleolin; Protein C23", "protein_names_refseq": "nucleolin", "tax_id": 10090, "disease": "", "pathway": " (mmu:17975); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 38, "publication_id_list": "10.1101/2023.09.13.557529;17242355;17622165;1860869;19144319;19524510;21183079;21474449;21518874;21540332;21750661;22645316;23806337;24129315;24991885;26495903;28784777;2906027;31219806;3137346;32152506;33300544;33725478;34203471;34428180;34887587;35820727;35984892;36210013;36288343;37453647;37507081;38409136;38784400;39288892;39627609;8065340;9642267", "class_list": "glycogene", "function": "Long non-coding RNA Snhg15 promotes preosteoblast proliferation by interacting with and stabilizing nucleolin., [RefSeq, PubMed]; Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats (By similarity)., [UniProtKB, PubMed]; Nucleolin myocardial-specific knockout exacerbates glucose metabolism disorder in endotoxemia-induced myocardial injury. Publication Status: Online-Only, [RefSeq, PubMed]; RGS6 drives cardiomyocyte death following nucleolar stress by suppressing Nucleolin/miRNA-21. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 27, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 28, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q548M9;Q61991;Q8BQD8;Q99K50", "ec_number_list": [], "go_molecular_function": "GO:0035368 selenocysteine insertion sequence binding;GO:0003723 RNA binding;GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005938 cell cortex;GO:0009986 cell surface", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:2000232 regulation of rRNA processing;GO:0001525 angiogenesis;GO:0006897 endocytosis;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 4.3, "record_id": "P09405-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000001001.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3KGV1-1", "uniprot_id": [ { "id": "ODFP2_MOUSE", "url": "https://www.uniprot.org/uniprot/A3KGV1", "type": "external" } ], "mass": 95541.0, "length": 830, "protein_name": "Outer dense fiber protein 2", "gene_name": "Odf2", "organism": "Mouse", "refseq_name": "outer dense fiber protein 2 isoform a", "refseq_ac": [ { "id": "NP_001106684", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106684", "type": "external" } ], "gene_names_uniprotkb": "Odf2; Odf84", "gene_names_refseq": "MMTEST29; Odf2", "protein_names_uniprotkb": "Outer dense fiber protein 2; 84 kDa outer dense fiber protein; Cenexin; Outer dense fiber of sperm tails protein 2", "protein_names_refseq": "84 kDa outer dense fiber protein; cenexin; outer dense fiber of sperm tails protein 2; outer dense fiber protein 2 isoform a; outer dense fiber protein 2", "tax_id": 10090, "disease": "microcephaly (Disease Ontology:DOID:10907)", "pathway": " (mmu:18286); (R-MMU-2565942); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-5620912); (R-MMU-8854518)", "pathway_count": 8, "publication_count": 20, "publication_id_list": "15852003;21750661;23386061;25361759;25428506;26961893;30084848;30623524;30779550;30787442;31475146;31599954;34428180;35820727;37198331;37364712;37838951;38038747;9045620;9740324", "class_list": "", "function": "Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the localization of PLK1 and NIN to the centrosomes. Required for the formation and/or maintenance of normal CETN1 assembly (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Stable expression and multi-site location of Odf2 in mouse oocytes, sperm and early embryos., [RefSeq, PubMed]; [Impacts of ODF2 gene knockdown on the sperm motility and fertility of male mice]., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A3KGV5;A3KGV6;O35135;O35496;Q3TH68;Q3UP80;Q6PGI6", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0001520 outer dense fiber;GO:0000922 spindle pole;GO:0005813 centrosome;GO:0005874 microtubule;GO:0005929 cilium", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:1902017 regulation of cilium assembly;GO:0044782 cilium organization", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "A3KGV1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P60670-1", "uniprot_id": [ { "id": "NPL4_MOUSE", "url": "https://www.uniprot.org/uniprot/P60670", "type": "external" } ], "mass": 68017.0, "length": 608, "protein_name": "Nuclear protein localization protein 4 homolog", "gene_name": "Nploc4", "organism": "Mouse", "refseq_name": "nuclear protein localization protein 4 homolog isoform A", "refseq_ac": [ { "id": "NP_001181952", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181952", "type": "external" } ], "gene_names_uniprotkb": "Nploc4; Kiaa1499; Npl4", "gene_names_refseq": "Npl4; Nploc4; mKIAA1499", "protein_names_uniprotkb": "Nuclear protein localization protein 4 homolog; Protein NPL4", "protein_names_refseq": "nuclear protein localization 4 homolog; nuclear protein localization protein 4 homolog isoform A; nuclear protein localization protein 4 homolog", "tax_id": 10090, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (mmu:217365); (R-MMU-110320); (R-MMU-8951664); (R-MMU-9755511)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "16103111;17491009;21750661;23806337;24160817;26112410;26495903;37507081", "class_list": "", "function": "Structural analysis of the p97-Npl4-Ufd1 interface, [RefSeq, PubMed]; The p97-Ufd1-Npl4 complex couples ubiquitinated IP(3) receptors to proteasomal degradation and, thus, plays a key role in IP(3) receptor processing, [RefSeq, PubMed]; The study revealed a regulatory role of the p97-Npl4-Ufd1 complex in regulating a partial degradation of the NF-kappaB subunit p100., [RefSeq, PubMed]; The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1ATY4;B1ATY5", "ec_number_list": [], "go_molecular_function": "GO:0036435 K48-linked polyubiquitin modification-dependent protein binding;GO:0008270 zinc ion binding;GO:0051117 ATPase binding;GO:0031625 ubiquitin protein ligase binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0036503 ERAD pathway;GO:0007030 Golgi organization;GO:0030970 retrograde protein transport, ER to cytosol", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P60670-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6ZPR5-1", "uniprot_id": [ { "id": "NSMA3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6ZPR5", "type": "external" } ], "mass": 93276.0, "length": 823, "protein_name": "Sphingomyelin phosphodiesterase 4", "gene_name": "Smpd4", "organism": "Mouse", "refseq_name": "sphingomyelin phosphodiesterase 4 isoform 4", "refseq_ac": [ { "id": "NP_001158081", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158081", "type": "external" } ], "gene_names_uniprotkb": "Smpd4; Kiaa1418", "gene_names_refseq": "4122402O22Rik; Smpd4", "protein_names_uniprotkb": "Sphingomyelin phosphodiesterase 4; 3.1.4.12; Neutral sphingomyelinase 3; Neutral sphingomyelinase III; nSMase-3; nSMase3", "protein_names_refseq": "nSMase3; neutral membrane (neutral sphingomyelinase-3); neutral sphingomyelinase 3; neutral sphingomyelinase III; sphingomyelin phosphodiesterase 4 isoform 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:77626); (R-MMU-9840310)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "21183079;21750661;25180167;30084848;31142202;31219806;34428180;36210013", "class_list": "", "function": "Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide (PubMed:25180167). It has a relevant role in the homeostasis of membrane sphingolipids, thereby influencing membrane integrity, and endoplasmic reticulum organization and function. May sensitize cells to DNA damage-induced apoptosis. In skeletal muscle, mediates TNF-stimulated oxidant production (PubMed:25180167)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TPE0;Q3TPP1;Q8CBJ5;Q8CD12;Q8CD83;Q8R0J3;Q9CX74", "ec_number_list": [ { "id": "3.1.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.12", "type": "external" }, { "id": "3.1.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.3", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004767 sphingomyelin phosphodiesterase activity;GO:0050290 sphingomyelin phosphodiesterase D activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005635 nuclear envelope;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0046513 ceramide biosynthetic process;GO:0046475 glycerophospholipid catabolic process;GO:0071356 cellular response to tumor necrosis factor;GO:0006685 sphingomyelin catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6ZPR5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80WB5-1", "uniprot_id": [ { "id": "NTAQ1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80WB5", "type": "external" } ], "mass": 24337.0, "length": 209, "protein_name": "Protein N-terminal glutamine amidohydrolase", "gene_name": "Ntaq1", "organism": "Mouse", "refseq_name": "protein N-terminal glutamine amidohydrolase isoform 1", "refseq_ac": [ { "id": "NP_084010", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084010", "type": "external" } ], "gene_names_uniprotkb": "Ntaq1; Wdyhv1", "gene_names_refseq": "2410187C16Rik; Ntaq1; Wdyhv1", "protein_names_uniprotkb": "Protein N-terminal glutamine amidohydrolase; 3.5.1.122; N-terminal Gln amidase; Nt(Q)-amidase; Protein NH2-terminal glutamine deamidase; WDYHV motif-containing protein 1", "protein_names_refseq": "N-terminal Gln amidase; WDYHV motif containing 1; WDYHV motif-containing protein 1; nt(Q)-amidase; protein N-terminal glutamine amidohydrolase isoform 1; protein N-terminal glutamine amidohydrolase; protein NH2-terminal glutamine deamidase", "tax_id": 10090, "disease": "", "pathway": " (mmu:76773)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "19560421;21750661;31599954", "class_list": "", "function": "Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Site-directed mutagenesis of Ntaq1 and its crystal structure indicate that the active site and catalytic mechanism of Nt(Q)-amidase are similar to those of transglutaminases., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.1.122", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.122", "type": "external" } ], "go_molecular_function": "GO:0008418 protein-N-terminal asparagine amidohydrolase activity;GO:0070773 protein-N-terminal glutamine amidohydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0036211 protein modification process;GO:0030163 protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q80WB5-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q810U4-1", "uniprot_id": [ { "id": "NRCAM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q810U4", "type": "external" } ], "mass": 138522.0, "length": 1256, "protein_name": "Neuronal cell adhesion molecule", "gene_name": "Nrcam", "organism": "Mouse", "refseq_name": "neuronal cell adhesion molecule isoform 2 precursor", "refseq_ac": [ { "id": "NP_001139503", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139503", "type": "external" } ], "gene_names_uniprotkb": "Nrcam; Kiaa0343", "gene_names_refseq": "Bravo; C030017F07Rik; C130076O07Rik; Nrcam; mKIAA0343", "protein_names_uniprotkb": "Neuronal cell adhesion molecule; Neuronal surface protein Bravo; Ng-CAM-related; NgCAM-related cell adhesion molecule; Nr-CAM; mBravo", "protein_names_refseq": "mBravo; neuron-glia-CAM-related cell adhesion molecule; neuronal cell adhesion molecule isoform 2 precursor; neuronal surface protein Bravo; ng-CAM-related; ngCAM-related cell adhesion molecule; nr-CAM", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); MASA syndrome (Disease Ontology:DOID:0060246); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:319504)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;11564762;14602817;16039564;20188654;21183079;21750661;23897819;24719088;25428506;30084848;30899004;33300544;40885482", "class_list": "", "function": "Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding (PubMed:11564762). Plays a role in mediating cell-cell contacts between Schwann cells and axons (PubMed:20188654). Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters (PubMed:14602817, PubMed:20188654). Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier (PubMed:24719088)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 1, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 16, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 16, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 16, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 16, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 41, "disease_count": 3, "glyco_site_count": 21, "binding_glycan_count": 0, "secondary_ac_list": "Q80U33;Q8BLG8;Q8BX92;Q8BYJ8", "ec_number_list": [], "go_molecular_function": "GO:0030506 ankyrin binding;GO:0098632 cell-cell adhesion mediator activity;GO:0086080 protein binding involved in heterotypic cell-cell adhesion", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005576 extracellular region;GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0005929 cilium", "go_biological_process": "GO:0001525 angiogenesis;GO:0007417 central nervous system development;GO:0098609 cell-cell adhesion;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 7.4, "record_id": "Q810U4-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RKR3-1", "uniprot_id": [ { "id": "ISLR2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5RKR3", "type": "external" } ], "mass": 79758.0, "length": 745, "protein_name": "Immunoglobulin superfamily containing leucine-rich repeat protein 2", "gene_name": "Islr2", "organism": "Mouse", "refseq_name": "immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform a", "refseq_ac": [ { "id": "NP_001155007", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155007", "type": "external" } ], "gene_names_uniprotkb": "Islr2; Kiaa1465; Linx", "gene_names_refseq": "B930052A04Rik; Islr2; Linx; Mbu-3; mKIAA1465", "protein_names_uniprotkb": "Immunoglobulin superfamily containing leucine-rich repeat protein 2; Leucine-rich repeat domain and immunoglobulin domain-containing axon extension protein", "protein_names_refseq": "immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform a; immunoglobulin superfamily containing leucine-rich repeat protein 2; leucine-rich repeat domain and immunoglobulin domain containing axon extension protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:320563)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;19755105;21183079;21750661;30899004", "class_list": "", "function": "Required for axon extension during neural development., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 7, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 7, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 7, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 7, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 10, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "C8XPY9;Q6ZPQ3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0007399 nervous system development;GO:0045773 positive regulation of axon extension", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q5RKR3-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60825-1", "uniprot_id": [ { "id": "NPT2A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60825", "type": "external" } ], "mass": 68774.0, "length": 637, "protein_name": "Sodium-dependent phosphate transport protein 2A", "gene_name": "Slc34a1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Slc34a1; Npt2; Slc17a2", "gene_names_refseq": "", "protein_names_uniprotkb": "Sodium-dependent phosphate transport protein 2A; Na(+)-dependent phosphate cotransporter 2A; Na(+)/Pi cotransporter 2A; NaPi-2a; NaPi-7; Sodium-phosphate transport protein 2A; Sodium/phosphate cotransporter 2A; Solute carrier family 34 member 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "hypophosphatemia (Disease Ontology:DOID:0050336); hereditary hypophosphatemic rickets with hypercalciuria (Disease Ontology:DOID:0050947); infantile hypercalcemia 2 (Disease Ontology:DOID:0061135); hypophosphatemic nephrolithiasis/osteoporosis 1 (Disease Ontology:DOID:0080077); Fanconi renotubular syndrome 2 (Disease Ontology:DOID:0080758); Fanconi syndrome (Disease Ontology:DOID:1062); hypothyroidism (Disease Ontology:DOID:1459); nephrolithiasis (Disease Ontology:DOID:585); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784); hyperthyroidism (Disease Ontology:DOID:7998); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898)", "pathway": " (R-MMU-427589); (R-MMU-5683826)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10497181;11950846;21183079;21750661;22645316;29187734;35428804;35459732;35820727;7478940;8070635;8693007", "class_list": "", "function": "Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane (PubMed:7478940, PubMed:8070635). The cotransport has a Na(+):Pi stoichiometry of 3:1 and is electrogenic (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 12, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "E9QKA0;Q62110;Q62111;Q62112;Q62113;Q62114;Q62115;Q62116;Q62564", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0030165 PDZ domain binding;GO:0005436 sodium:phosphate symporter activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005768 endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005903 brush border", "go_biological_process": "GO:1904383 response to sodium phosphate;GO:0010288 response to lead ion;GO:0046686 response to cadmium ion;GO:0046849 bone remodeling;GO:0045838 positive regulation of membrane potential", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q60825-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11798-1", "uniprot_id": [ { "id": "KCC2A_MOUSE", "url": "https://www.uniprot.org/uniprot/P11798", "type": "external" } ], "mass": 54115.0, "length": 478, "protein_name": "Calcium/calmodulin-dependent protein kinase type II subunit alpha", "gene_name": "Camk2a", "organism": "Mouse", "refseq_name": "calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 3", "refseq_ac": [ { "id": "NP_001273738", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273738", "type": "external" } ], "gene_names_uniprotkb": "Camk2a", "gene_names_refseq": "CaMKII; Camk2a; mKIAA0968", "protein_names_uniprotkb": "Calcium/calmodulin-dependent protein kinase type II subunit alpha; 2.7.11.17; CaM kinase II subunit alpha; CaMK-II subunit alpha", "protein_names_refseq": "CaMK II; alpha-CaMKII; caM kinase II subunit alpha; caMK-II subunit alpha; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 3; calcium/calmodulin-dependent protein kinase type II subunit alpha", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal dominant intellectual developmental disorder 53 (Disease Ontology:DOID:0080228); autosomal recessive intellectual developmental disorder 63 (Disease Ontology:DOID:0081224); heart conduction disease (Disease Ontology:DOID:10273); Alzheimer's disease (Disease Ontology:DOID:10652); transient cerebral ischemia (Disease Ontology:DOID:224); high grade glioma (Disease Ontology:DOID:3070); bipolar disorder (Disease Ontology:DOID:3312); middle cerebral artery infarction (Disease Ontology:DOID:3525)", "pathway": " (mmu:12322); (R-MMU-3371571); (R-MMU-399719); (R-MMU-4086398); (R-MMU-438066); (R-MMU-5578775); (R-MMU-5673000); (R-MMU-5673001); (R-MMU-877300); (R-MMU-936837)", "pathway_count": 10, "publication_count": 28, "publication_id_list": "10.1101/2023.09.13.557529;15994560;16452087;18034455;19257910;21183079;21750661;22363696;22645316;23502535;23805378;24052497;24349346;24374198;2543961;27799554;28011936;28130356;28642476;28657654;32134364;33300544;34678516;35822049;39390438;40684658;40885482;8524307", "class_list": "", "function": "Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation (By similarity). Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development (By similarity). Also regulates the migration of developing neurons (By similarity). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378). Phosphorylates the transcription factor ETS1 in response to calcium signaling, thereby decreasing ETS1 affinity for DNA (PubMed:15994560). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). In response to interferon-beta (IFN-beta) stimulation, stimulates the JAK-STAT signaling pathway (By similarity). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of PSAT1, inhibiting ferroptosis by promoting GPX4 hydroxylation and stability (By similarity). Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (PubMed:23502535)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Has no kinase activity., [UniProtKB, PubMed]; Loss of mitochondrial Ca[2+] response and CaMKII/ERK activation by LRRK2[R1441G] mutation correlate with impaired depolarization-induced mitophagy. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 9, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q61284;Q6ZWN4", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "7.2.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.10", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0014069 postsynaptic density;GO:0030424 axon", "go_biological_process": "GO:0002931 response to ischemia;GO:0006468 protein phosphorylation;GO:0035235 ionotropic glutamate receptor signaling pathway;GO:0006816 calcium ion transport;GO:2000124 regulation of endocannabinoid signaling pathway", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "P11798-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DC28-1", "uniprot_id": [ { "id": "KC1D_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DC28", "type": "external" } ], "mass": 47316.0, "length": 415, "protein_name": "Casein kinase I isoform delta", "gene_name": "Csnk1d", "organism": "Mouse", "refseq_name": "casein kinase I isoform delta isoform 1", "refseq_ac": [ { "id": "NP_620690", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620690", "type": "external" } ], "gene_names_uniprotkb": "Csnk1d; Hckid", "gene_names_refseq": "1200006A05Rik; Csnk1d; D930010H05Rik", "protein_names_uniprotkb": "Casein kinase I isoform delta; 2.7.11.1; 2.7.11.26; CKI-delta; CKId; Tau-protein kinase CSNK1D", "protein_names_refseq": "CKI-delta; CKId; casein kinase I isoform delta isoform 1; tau-protein kinase CSNK1D", "tax_id": 10090, "disease": "syndromic X-linked intellectual disability Najm type (Disease Ontology:DOID:0060807); advanced sleep phase syndrome 2 (Disease Ontology:DOID:0110012); Alzheimer's disease (Disease Ontology:DOID:10652); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); colon cancer (Disease Ontology:DOID:219)", "pathway": " (mmu:104318); (R-MMU-204005); (R-MMU-2565942); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-5620912); (R-MMU-6791226); (R-MMU-8854518)", "pathway_count": 10, "publication_count": 27, "publication_id_list": "10.1101/2023.09.13.557529;10.3389/fragi.2021.757801;10848614;11779462;12924632;16014721;17101137;17242355;19414593;19948962;20145109;20192920;20421981;21183079;21750661;21930935;22645316;23636092;24129315;29191835;31219806;32782141;35822049;36852467;37578019;37828378;40885482", "class_list": "", "function": "Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. Phosphorylates NEDD9/HEF1 (PubMed:29191835). EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Involvement of casein kinase 1 epsilon/delta (Csnk1e/d) in the pathogenesis of familial Parkinson's disease caused by CHCHD2., [RefSeq, PubMed]; This gene encodes a member of the casein kinase I (CKI) family of serine/threonine protein kinases. A highly similar human protein regulates an array of cellular processes by influencing the Wnt and hedgehog signaling pathways. The encoded protein may also be involved in the regulation of apoptosis, circadian rhythm, microtubule dynamics, chromosome segregation, and p53-mediated effects on growth. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 5, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TZK2;Q99KK4", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0050321 tau-protein kinase activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0006897 endocytosis;GO:0007165 signal transduction;GO:0016055 Wnt signaling pathway;GO:0042752 regulation of circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "Q9DC28-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30415-1", "uniprot_id": [ { "id": "NKTR_MOUSE", "url": "https://www.uniprot.org/uniprot/P30415", "type": "external" } ], "mass": 163449.0, "length": 1453, "protein_name": "NK-tumor recognition protein", "gene_name": "Nktr", "organism": "Mouse", "refseq_name": "NK-tumor recognition protein", "refseq_ac": [ { "id": "NP_035048", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035048", "type": "external" } ], "gene_names_uniprotkb": "Nktr", "gene_names_refseq": "5330401F18Rik; D9Wsu172e; Nktr", "protein_names_uniprotkb": "NK-tumor recognition protein; 5.2.1.8; NK-TR protein; Natural-killer cells cyclophilin-related protein; PPIase; Peptidyl-prolyl cis-trans isomerase NKTR", "protein_names_refseq": "NK-TR protein; NK-tumor recognition protein; PPIase; cyclophilin-related protein; natural killer tumor recognition protein; natural-killer cells cyclophilin-related protein; peptidyl-prolyl cis-trans isomerase NKTR", "tax_id": 10090, "disease": "", "pathway": " (mmu:18087)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "21183079;21750661;28528544;29187734;31219806;34428180;36210013;40997131;8421688", "class_list": "", "function": "PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Component of a putative tumor-recognition complex involved in the function of NK cells., [UniProtKB, UniProtKB]; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F8VPR8;Q3UNH0", "ec_number_list": [ { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" } ], "go_molecular_function": "GO:0016018 cyclosporin A binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P30415-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66X22-1", "uniprot_id": [ { "id": "NLR9B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q66X22", "type": "external" } ], "mass": 114802.0, "length": 1003, "protein_name": "NACHT, LRR and PYD domains-containing protein 9B", "gene_name": "Nlrp9b", "organism": "Mouse", "refseq_name": "NACHT, LRR and PYD domains-containing protein 9B", "refseq_ac": [ { "id": "NP_918947", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_918947", "type": "external" } ], "gene_names_uniprotkb": "Nlrp9b; Nalp9b; Nalp9", "gene_names_refseq": "Nalp-delta; Nalp9b; Nlrp9b; Nlrp9", "protein_names_uniprotkb": "NACHT, LRR and PYD domains-containing protein 9B; NALP-delta", "protein_names_refseq": "NACHT, LRR and PYD containing protein 9b; NACHT, LRR and PYD domains-containing protein 9B; NLR family, pyrin domain containing 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:243874)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15317747;21750661;26411641;28636595;29655793;32399794", "class_list": "", "function": "As the sensor component of the NLRP9 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens, including rotavirus, initiates the formation of the inflammasome polymeric complex, made of NLRP9, PYCARD and CASP1. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and release in the extracellular milieu. The active cytokines stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death. NLRP9 inflammasome activation may be initiated by DHX9 interaction with viral double-stranded RNA (dsRNA), preferentially to short dsRNA segments., [UniProtKB, PubMed]; Maternally contributed Nlrp9b expressed in human and mouse ovarian follicles contributes to early murine preimplantation development., [RefSeq, PubMed]; Provide the first evidence that the NLRP9B protein is dispensable for oocyte maturation and early embryonic development in the mouse, [RefSeq, PubMed]; The findings indicated that NLRP9b(-/-) improved the survival rate of cecal ligation and puncture -induced acute lung injury mice, and inhibited pulmonary histopathological alterations, inflammation, and apoptosis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6UTW9", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0061702 canonical inflammasome complex", "go_biological_process": "GO:0032741 positive regulation of interleukin-18 production;GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0050727 regulation of inflammatory response;GO:0070269 pyroptotic inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q66X22-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70255-1", "uniprot_id": [ { "id": "NFIC_MOUSE", "url": "https://www.uniprot.org/uniprot/P70255", "type": "external" } ], "mass": 48768.0, "length": 439, "protein_name": "Nuclear factor 1 C-type", "gene_name": "Nfic", "organism": "Mouse", "refseq_name": "nuclear factor 1 C-type isoform a", "refseq_ac": [ { "id": "NP_032714", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032714", "type": "external" } ], "gene_names_uniprotkb": "Nfic", "gene_names_refseq": "1110019L22Rik; 1500041O16Rik; NF1-C; Nfic", "protein_names_uniprotkb": "Nuclear factor 1 C-type; CCAAT-box-binding transcription factor; CTF; NF-I/C; NF1-C; NFI-C; Nuclear factor 1/C; Nuclear factor I/C; TGGCA-binding protein", "protein_names_refseq": "CCAAT-box-binding transcription factor; CTF; NF-I/C; NFI-C; TGGCA-binding protein; nuclear factor 1 C-type isoform a; nuclear factor 1 C-type; nuclear factor 1-C2; nuclear factor 1/C", "tax_id": 10090, "disease": "", "pathway": " (mmu:18029)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10087299;12568726;17242355;19131326;21183079;21750661;34428180;34930914;36669387;37353485;9056636", "class_list": "", "function": "NFIC attenuates rheumatoid arthritis-induced inflammatory response in mice by regulating PTEN/SENP8 transcription., [RefSeq, PubMed]; NFIC regulates ribosomal biology and ER stress in pancreatic acinar cells and restrains PDAC initiation. Publication Status: Online-Only, [RefSeq, PubMed]; Nuclear factor I-C disrupts cellular homeostasis between autophagy and apoptosis via miR-200b-Ambra1 in neural tube defects. Publication Status: Online-Only, [RefSeq, PubMed]; Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O09072;P70256;Q3U2I9;Q99MA3;Q99MA4;Q99MA5;Q99MA6;Q99MA7;Q99MA8;Q9R1G3", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0003690 double-stranded DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0001650 fibrillar center", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P70255-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2RSY1-1", "uniprot_id": [ { "id": "KANL3_MOUSE", "url": "https://www.uniprot.org/uniprot/A2RSY1", "type": "external" } ], "mass": 96135.0, "length": 903, "protein_name": "KAT8 regulatory NSL complex subunit 3", "gene_name": "Kansl3", "organism": "Mouse", "refseq_name": "KAT8 regulatory NSL complex subunit 3 isoform 1", "refseq_ac": [ { "id": "NP_001297442", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297442", "type": "external" } ], "gene_names_uniprotkb": "Kansl3; Kiaa1310; Nsl3", "gene_names_refseq": "4632411B12Rik; 4932435K23; Kansl3; Kiaa1310; mKIAA1310", "protein_names_uniprotkb": "KAT8 regulatory NSL complex subunit 3; NSL complex protein NSL3; Non-specific lethal 3 homolog", "protein_names_refseq": "KAT8 regulatory NSL complex subunit 3 isoform 1; NSL complex protein NSL3; non-specific lethal 3 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:226976); (R-MMU-3214847); (R-MMU-9772755)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "21183079;21606357;21750661;24842875;25428506;26192747;27802388;30059200;31219806;31576060;32782141;36852467;37624894;38769918;40997131", "class_list": "", "function": "Loss of KANSL3 leads to defective inner cell mass and early embryonic lethality., [RefSeq, PubMed]; Loss of the lysine acetyltransferase MOF or its associated NSL-complex members KANSL2 or KANSL3 leads to a stochastic accumulation of nuclear abnormalities with genomic instability patterns including chromothripsis. Erratum:[Nat Cell Biol. 2023 Apr;25(4):626. doi: 10.1038/s41556-023-01106-y. PMID: 36849559], [RefSeq, PubMed]; Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (By similarity). The NSL complex also acts as a regulator of gene expression in mitochondria (By similarity). Within the NSL complex, KANSL3 is required to promote KAT8 association with mitochondrial DNA (By similarity). Required for transcription of intraciliary transport genes in both ciliated and non-ciliated cells (PubMed:37624894). This is necessary for cilium assembly in ciliated cells and for organization of the microtubule cytoskeleton in non-ciliated cells (PubMed:37624894). Also required within the NSL complex to maintain nuclear architecture stability by promoting KAT8-mediated acetylation of lamin LMNA (PubMed:31576060). Plays an essential role in spindle assembly during mitosis (By similarity). Acts as a microtubule minus-end binding protein which stabilizes microtubules and promotes their assembly (By similarity). Indispensable during early embryonic development where it is required for proper lineage specification and maintenance during peri-implantation development and is essential for implantation (PubMed:38769918)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 17, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 17, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 17, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 18, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZPU0;Q8C0P9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000922 spindle pole;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005874 microtubule;GO:0000123 histone acetyltransferase complex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0006325 chromatin organization;GO:1903108 regulation of mitochondrial transcription", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "A2RSY1-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63073-1", "uniprot_id": [ { "id": "IF4E_MOUSE", "url": "https://www.uniprot.org/uniprot/P63073", "type": "external" } ], "mass": 25053.0, "length": 217, "protein_name": "Eukaryotic translation initiation factor 4E", "gene_name": "Eif4e", "organism": "Mouse", "refseq_name": "eukaryotic translation initiation factor 4E isoform 1", "refseq_ac": [ { "id": "NP_031943", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031943", "type": "external" } ], "gene_names_uniprotkb": "Eif4e", "gene_names_refseq": "EG668879; Eif4e-ps; Eif4e; If4e; eIF-4E", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 4E; eIF-4E; eIF-4F 25 kDa subunit; eIF4E; mRNA cap-binding protein", "protein_names_refseq": "eIF-4F 25 kDa subunit; eukaryotic translation initiation factor 4E isoform 1; mRNA cap-binding protein", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autistic disorder (Disease Ontology:DOID:12849); candidiasis (Disease Ontology:DOID:1508); vascular dementia (Disease Ontology:DOID:8725)", "pathway": " (mmu:13684); (R-MMU-1169408); (R-MMU-156827); (R-MMU-159227); (R-MMU-159230); (R-MMU-159231); (R-MMU-166208); (R-MMU-429947); (R-MMU-72649); (R-MMU-72662); (R-MMU-72702); (R-MMU-72706)", "pathway_count": 12, "publication_count": 51, "publication_id_list": "10394359;11500381;11575918;12554669;15247416;15254222;15349891;15491137;15574771;15657436;16705177;16835235;17074885;17689282;18055695;18391071;18515545;18805096;19114715;19262567;19574459;2037592;20535623;21750661;22900038;22902403;23172145;23263185;23269249;24714040;25456498;25915475;25923732;2663851;27065194;28325843;28674170;28745319;28864377;29367404;29941989;31042468;33055213;35481869;36315645;36843541;37507081;8577715;8662663;9155017;9200613", "class_list": "", "function": "Acts in the cytoplasm to initiate and regulate protein synthesis and is required in the nucleus for export of a subset of mRNAs from the nucleus to the cytoplasm which promotes processes such as RNA capping, processing and splicing (PubMed:18805096, PubMed:25456498, PubMed:31042468, PubMed:36843541, PubMed:8577715). Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:18805096). This protein recognizes and binds the 7-methylguanosine (m7G)-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures (By similarity). Together with EIF4G1, antagonizes the scanning promoted by EIF1-EIF4G1 and is required for TISU translation, a process where the TISU element recognition makes scanning unnecessary (By similarity). In addition to its role in translation initiation, also acts as a regulator of translation and stability in the cytoplasm (PubMed:18805096, PubMed:25456498). Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression: in the complex, EIF4E mediates the binding to the mRNA cap (PubMed:18805096). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (PubMed:25456498). In P-bodies, component of a complex that mediates the storage of translationally inactive mRNAs in the cytoplasm and prevents their degradation (By similarity). May play an important role in spermatogenesis through translational regulation of stage-specific mRNAs during germ cell development (By similarity). As well as its roles in translation, also involved in mRNA nucleocytoplasmic transport (PubMed:8577715). Its role in mRNA export from the nucleus to the cytoplasm relies on its ability to bind the m7G cap of RNAs and on the presence of the 50-nucleotide EIF4E sensitivity element (4ESE) in the 3'UTR of sensitive transcripts (PubMed:17074885). Interaction with the 4ESE is mediated by LRPPRC which binds simultaneously to both EIF4E and the 4ESE, thereby acting as a platform for assembly for the RNA export complex (PubMed:19262567, PubMed:28325843). EIF4E-dependent mRNA export is independent of ongoing protein or RNA synthesis and is also NFX1-independent but is XPO1-dependent with LRPPRC interacting with XPO1 to form an EIF4E-dependent mRNA export complex (PubMed:17074885). Alters the composition of the cytoplasmic face of the nuclear pore to promote RNA export by reducing RANBP2 expression, relocalizing nucleoporin NUP214 and increasing expression of RANBP1 and RNA export factors DDX19 and GLE1 (PubMed:22902403). Promotes the nuclear export of cyclin CCND1 mRNA (PubMed:11500381, PubMed:15574771, PubMed:18391071, PubMed:8577715). Promotes the nuclear export of NOS2/iNOS mRNA (By similarity). Promotes the nuclear export of MDM2 mRNA (By similarity). Also promotes the export of additional mRNAs, including others involved in the cell cycle (PubMed:17074885). In the nucleus, binds to capped splice factor-encoding mRNAs and stimulates their nuclear export to enhance splice factor production by increasing their cytoplasmic availability to the translation machinery (PubMed:36843541). May also regulate splicing through interaction with the spliceosome in an RNA and m7G cap-dependent manner (PubMed:36843541). Also binds to some pre-mRNAs and may play a role in their recruitment to the spliceosome (PubMed:36843541). Promotes steady-state capping of a subset of coding and non-coding RNAs by mediating nuclear export of capping machinery mRNAs including RNMT, RNGTT and RAMAC to enhance their translation (PubMed:33055213). Stimulates mRNA 3'-end processing by promoting the expression of several core cleavage complex factors required for mRNA cleavage and polyadenylation, and may also have a direct effect through its interaction with the CPSF3 cleavage enzyme (PubMed:31042468). Rescues cells from apoptosis by promoting activation of serine/threonine-protein kinase AKT1 through mRNA export of NBS1 which potentiates AKT1 phosphorylation and also through mRNA export of AKT1 effectors, allowing for increased production of these proteins (PubMed:18391071)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Increasing the levels eIF4E in mice results in exaggerated cap-dependent translation and aberrant behaviours reminiscent of autism, including repetitive and perseverative behaviours and social interaction deficits, [RefSeq, PubMed]; Thermodynamic studies reveal the unique, large and positive heat capacity changes at constant pressure that accompany interactions between eIF4E and the mRNA 5' cap., [RefSeq, PubMed]; This gene encodes a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. It has also been associated with autism spectrum disorders. Consistently, knockout of this gene results in increased translation of neuroligins, postsynaptic proteins linked to autism spectrum disorders. Pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]., [RefSeq]; Translational control by eIF4E regulates the synthesis of neuroligins, maintaining the excitation-to-inhibition balance, and its dysregulation engenders autism spectrum disorder-like phenotypes, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P20415", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0000340 RNA 7-methylguanosine cap binding;GO:0003743 translation initiation factor activity;GO:0098808 mRNA cap binding;GO:0031370 eukaryotic initiation factor 4G binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006406 mRNA export from nucleus;GO:0006417 regulation of translation;GO:0045665 negative regulation of neuron differentiation;GO:0045931 positive regulation of mitotic cell cycle;GO:0006413 translational initiation", "synthesized_glycan_count": 0, "hit_score": 5.4, "record_id": "P63073-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TMB8-1", "uniprot_id": [ { "id": "CYFP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TMB8", "type": "external" } ], "mass": 145241.0, "length": 1253, "protein_name": "Cytoplasmic FMR1-interacting protein 1", "gene_name": "Cyfip1", "organism": "Mouse", "refseq_name": "cytoplasmic FMR1-interacting protein 1 isoform a", "refseq_ac": [ { "id": "NP_001158133", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158133", "type": "external" } ], "gene_names_uniprotkb": "Cyfip1; Kiaa0068; Shyc; Sra1", "gene_names_refseq": "Cyfip1; E030028J09Rik; P140SRA-1; P140sra1; Shyc; Sra-1; Sra1; l(7)1Rl; l71Rl; l7Rl1; mKIAA0068; pl-1", "protein_names_uniprotkb": "Cytoplasmic FMR1-interacting protein 1; Specifically Rac1-associated protein 1; Sra-1", "protein_names_refseq": "cytoplasmic FMR1-interacting protein 1 isoform a; specifically Rac1-associated protein 1", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); chromosome 15q11.2 deletion syndrome (Disease Ontology:DOID:0060393); Schaaf-Yang syndrome (Disease Ontology:DOID:0111715); temporal lobe epilepsy (Disease Ontology:DOID:3328); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:20430); (R-MMU-2029482); (R-MMU-4420097); (R-MMU-5663213); (R-MMU-6798695); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013408); (R-MMU-9013423)", "pathway_count": 9, "publication_count": 20, "publication_id_list": "11438699;14765121;18805096;19524508;21750661;21946561;25428506;26740625;27605705;28011936;28528544;29187734;30084848;31219806;33300544;34428180;35820727;36210013;38391912;9756361", "class_list": "", "function": "Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (PubMed:27605705)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Differential Role of the RAC1-Binding Proteins FAM49b (CYRI-B) and CYFIP1 in Platelets. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88558;Q3U7Q7;Q5DU50;Q7TSZ5;Q80VN6;Q8CE85;Q99LY1", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0031267 small GTPase binding;GO:0030371 translation repressor activity;GO:0000340 RNA 7-methylguanosine cap binding;GO:0005522 profilin binding", "go_cellular_component": "GO:0030027 lamellipodium;GO:0031252 cell leading edge;GO:0043025 neuronal cell body;GO:0043195 terminal bouton;GO:0043197 dendritic spine", "go_biological_process": "GO:0006417 regulation of translation;GO:0031175 neuron projection development;GO:0032869 cellular response to insulin stimulus;GO:0050890 cognition;GO:0000902 cell morphogenesis", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q7TMB8-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61792-1", "uniprot_id": [ { "id": "LASP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61792", "type": "external" } ], "mass": 29994.0, "length": 263, "protein_name": "LIM and SH3 domain protein 1", "gene_name": "Lasp1", "organism": "Mouse", "refseq_name": "LIM and SH3 domain protein 1", "refseq_ac": [ { "id": "NP_034818", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034818", "type": "external" } ], "gene_names_uniprotkb": "Lasp1; Mln50", "gene_names_refseq": "Def-4; LASP-1; Lasp1; MLN 50; SH3P6; Tg(Col1a1-lacZ)1Ngma", "protein_names_uniprotkb": "LIM and SH3 domain protein 1; LASP-1; MLN 50; Metastatic lymph node gene 50 protein", "protein_names_refseq": "LIM and SH3 domain protein 1; Tg(11Col1a1)NG; metastatic lymph node gene 50 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:16796)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "15465019;19064729;21183079;21750661;22645316;23806337;26495903;32848054;33242526;33300544;34131132;34428180;34678516;35820727;35822049;36288343;37453647;37578083;38713618;40997131;9511759;9630982", "class_list": "", "function": "Cholesterol uptake in the intestine is regulated by the LASP1-AKT-NPC1L1 signaling pathway., [RefSeq, PubMed]; Hippocampal LASP1 ameliorates chronic stress-mediated behavioral responses in a mouse model of unpredictable chronic mild stress., [RefSeq, PubMed]; Lasp1 regulates adherens junction dynamics and fibroblast transformation in destructive arthritis. Publication Status: Online-Only, [RefSeq, PubMed]; Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity)., [UniProtKB]; Silenced LASP1 interacts with DNMT1 to promote TJP2 expression and attenuate articular cartilage injury in mice by suppressing TJP2 methylation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q62416", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051015 actin filament binding;GO:0015075 monoatomic ion transmembrane transporter activity;GO:0003779 actin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0098794 postsynapse", "go_biological_process": "GO:0006811 monoatomic ion transport", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q61792-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70263-1", "uniprot_id": [ { "id": "LNX1_MOUSE", "url": "https://www.uniprot.org/uniprot/O70263", "type": "external" } ], "mass": 80157.0, "length": 728, "protein_name": "E3 ubiquitin-protein ligase LNX", "gene_name": "Lnx1", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase LNX isoform 1", "refseq_ac": [ { "id": "NP_001153049", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153049", "type": "external" } ], "gene_names_uniprotkb": "Lnx1; Lnx", "gene_names_refseq": "Lnx1; Lnx", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase LNX; 2.3.2.27; Ligand of Numb protein X 1; Ligand of Numb-binding protein 1; Numb-binding protein 1; RING-type E3 ubiquitin transferase LNX", "protein_names_refseq": "E3 ubiquitin-protein ligase LNX isoform 1; E3 ubiquitin-protein ligase LNX; RING-type E3 ubiquitin transferase LNX; ligand of Numb protein X 1; ligand of Numb-binding protein 1; numb-binding protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:16924); (R-MMU-983168)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "11782429;14990566;16832352;21750661;29121065;30016717;30185604;31772302;32487755;35115665;9535908", "class_list": "", "function": "E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Hippocampal Lnx1-NMDAR multiprotein complex mediates initial social memory., [RefSeq, PubMed]; Isoform 2 provides an endocytic scaffold for IGSF5/JAM4., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Ligand-of-Numb protein X1 controls the coxsackievirus B3-induced myocarditis via regulating the stability of coxsackievirus and adenovirus receptor., [RefSeq, PubMed]; MicroRNA-325-3p Facilitates Immune Escape of Mycobacterium tuberculosis through Targeting LNX1 via NEK6 Accumulation to Promote Anti-Apoptotic STAT3 Signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Retrograde regulation of mossy fiber axon targeting and terminal maturation via postsynaptic Lnx1., [RefSeq, PubMed]; These findings provide functional insights into the LNX protein family, particularly the neuronal LNX1p70 isoform. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O70264;Q8BRI8;Q8CFR3", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0061630 ubiquitin protein ligase activity;GO:0030165 PDZ domain binding;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030054 cell junction;GO:0098794 postsynapse;GO:0098686 hippocampal mossy fiber to CA3 synapse", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0060074 synapse maturation;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "O70263-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q921G6-1", "uniprot_id": [ { "id": "LRCH4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q921G6", "type": "external" } ], "mass": 73163.0, "length": 680, "protein_name": "Leucine-rich repeat and calponin homology domain-containing protein 4", "gene_name": "Lrch4", "organism": "Mouse", "refseq_name": "leucine-rich repeat and calponin homology domain-containing protein 4 isoform 1", "refseq_ac": [ { "id": "NP_666276", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666276", "type": "external" } ], "gene_names_uniprotkb": "Lrch4", "gene_names_refseq": "2810008P14Rik; 2900069C24Rik; LRN; LRRN4; Lrch4; SAP25", "protein_names_uniprotkb": "Leucine-rich repeat and calponin homology domain-containing protein 4", "protein_names_refseq": "leucine rich repeat protein 4, neuronal; leucine-rich repeat and calponin homology domain-containing protein 4 isoform 1; leucine-rich repeat and calponin homology domain-containing protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:231798)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "16449650;21183079;21750661;30084848;30523158;31219806;34428180", "class_list": "", "function": "Accessory protein that regulates signaling by multiple TLRs, acting as a broad-spanning regulator of the innate immune response. In macrophages, binds LPS and promotes proper docking of LPS in lipid raft membrane. May be required for lipid raft maintenance., [UniProtKB, PubMed]; Identify Lrch4 as a broad-spanning regulator of the innate immune response, [RefSeq, PubMed]; SAP25 is a novel core component of the Sin3 corepressor complex whose subcellular location is regulated by PML., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "H3BLL3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016605 PML body", "go_biological_process": "GO:0034123 positive regulation of toll-like receptor signaling pathway;GO:0001765 membrane raft assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q921G6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O89091-1", "uniprot_id": [ { "id": "KLF10_MOUSE", "url": "https://www.uniprot.org/uniprot/O89091", "type": "external" } ], "mass": 51756.0, "length": 479, "protein_name": "Krueppel-like factor 10", "gene_name": "Klf10", "organism": "Mouse", "refseq_name": "Krueppel-like factor 10 isoform 1", "refseq_ac": [ { "id": "NP_038720", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038720", "type": "external" } ], "gene_names_uniprotkb": "Klf10; Gdnfif; Tieg1; Tieg", "gene_names_refseq": "EGR[a]; Egral; Gdnfif; Klf10; TIEG-1; Tieg1; Tieg; mGIF", "protein_names_uniprotkb": "Krueppel-like factor 10; GDNF-inducible factor; TGFB-inducible early growth response protein 1; TIEG-1; Transcription factor GIF; Transforming growth factor-beta-inducible early growth response protein 1; mGIF", "protein_names_refseq": "GDNF-inducible factor; Krueppel-like factor 10 isoform 1; Kruppel-like factor 10; TGFB inducible early growth response 1; TGFB-inducible early growth response protein 1; krueppel-like factor 10; transcription factor GIF; transforming growth factor-beta-inducible early growth response protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:21847)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "20070857;20385766;21471442;21750661;38217021;38499142;38582490;38615945;9348334;9745041", "class_list": "", "function": "Hepatic Klf10-Fh1 axis promotes exercise-mediated amelioration of NASH in mice., [RefSeq, PubMed]; KLF10/CBS increases the sensitivity of gastric carcinoma cells to methionine restriction by promoting sulfur transfer pathway., [RefSeq, PubMed]; Klf10 is involved in extracellular matrix calcification of chondrocytes alleviating chondrocyte senescence. Publication Status: Online-Only, [RefSeq, PubMed]; Kruppel-like factor 10 protects against metabolic dysfunction-associated steatohepatitis by regulating HNF4alpha-mediated metabolic pathways., [RefSeq, PubMed]; Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. May play a role in the cell cycle regulation (By similarity). Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O89091-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62046-1", "uniprot_id": [ { "id": "LRCH1_MOUSE", "url": "https://www.uniprot.org/uniprot/P62046", "type": "external" } ], "mass": 79076.0, "length": 709, "protein_name": "Leucine-rich repeat and calponin homology domain-containing protein 1", "gene_name": "Lrch1", "organism": "Mouse", "refseq_name": "leucine-rich repeat and calponin homology domain-containing protein 1 isoform 1", "refseq_ac": [ { "id": "NP_001028611", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028611", "type": "external" } ], "gene_names_uniprotkb": "Lrch1; Chdc1; Kiaa1016", "gene_names_refseq": "4832412D13Rik; Chdc1; Lrch1; mKIAA1016", "protein_names_uniprotkb": "Leucine-rich repeat and calponin homology domain-containing protein 1; Calponin homology domain-containing protein 1", "protein_names_refseq": "leucine-rich repeat and calponin homology domain-containing protein 1 isoform 1; leucine-rich repeat and calponin homology domain-containing protein 1", "tax_id": 10090, "disease": "multiple sclerosis (Disease Ontology:DOID:2377)", "pathway": " (mmu:380916)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "19144319;21183079;21750661;28028151;30084848;30779550;32727906", "class_list": "", "function": "Acts as a negative regulator of GTPase CDC42 by sequestering CDC42-guanine exchange factor DOCK8. Probably by preventing CDC42 activation, negatively regulates CD4(+) T-cell migration in response to chemokine stimulation., [UniProtKB, PubMed]; LRCH1 as a novel effector to restrain PKCalpha-DOCK8-Cdc42 module-induced T cell migration and ameliorate EAE., [RefSeq, PubMed]; LRCH1 deficiency enhances LAT signalosome formation and CD8(+) T cell responses against tumors and pathogens., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QLJ4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:1990869 cellular response to chemokine;GO:0034260 negative regulation of GTPase activity;GO:2000405 negative regulation of T cell migration", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P62046-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D5S7-1", "uniprot_id": [ { "id": "LRGUK_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D5S7", "type": "external" } ], "mass": 93190.0, "length": 820, "protein_name": "Leucine-rich repeat and guanylate kinase domain-containing protein", "gene_name": "Lrguk", "organism": "Mouse", "refseq_name": "leucine-rich repeat and guanylate kinase domain-containing protein isoform 3", "refseq_ac": [ { "id": "NP_083162", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083162", "type": "external" } ], "gene_names_uniprotkb": "Lrguk", "gene_names_refseq": "4921528H16Rik; Lrguk", "protein_names_uniprotkb": "Leucine-rich repeat and guanylate kinase domain-containing protein", "protein_names_refseq": "leucine-rich repeat and guanylate kinase domain-containing protein isoform 3; leucine-rich repeat and guanylate kinase domain-containing protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:74354)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25781171;28003339", "class_list": "", "function": "Identified LRGUK-1 as a protein critically involved in multiple aspects of sperm assembly and function. LRGUK-1 is required for appropriate acrosome attachment to the sperm heard, sperm head shaping via the manchette and tail growth from the basal body; specific loss of LRGUK-1 function results in oligoasthenoteratospermia in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspects of axoneme development (PubMed:25781171). Not essential for primary cilium biogenesis (PubMed:28003339)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004385 GMP kinase activity;GO:0005524 ATP binding;GO:0016301 kinase activity;GO:0016740 transferase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0001669 acrosomal vesicle;GO:0002177 manchette", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0035082 axoneme assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D5S7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16045-1", "uniprot_id": [ { "id": "LEG1_MOUSE", "url": "https://www.uniprot.org/uniprot/P16045", "type": "external" } ], "mass": 14866.0, "length": 135, "protein_name": "Galectin-1", "gene_name": "Lgals1", "organism": "Mouse", "refseq_name": "galectin-1", "refseq_ac": [ { "id": "NP_032521", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032521", "type": "external" } ], "gene_names_uniprotkb": "Lgals1; Gbp", "gene_names_refseq": "Gal-1; Galbp; L-14.5; L14; Lect14; Lgals1; galectin-1", "protein_names_uniprotkb": "Galectin-1; 14 kDa lectin; Beta-galactoside-binding lectin L-14-I; Gal-1; Galaptin; Lactose-binding lectin 1; Lectin galactoside-binding soluble 1; S-Lac lectin 1", "protein_names_refseq": "14 kDa lectin; S-Lac lectin 1; beta-galactoside binding protein; beta-galactoside-binding lectin L-14-I; galaptin; galectin-1; lactose-binding lectin 1; lectin galactoside-binding soluble 1", "tax_id": 10090, "disease": "lipoid nephrosis (Disease Ontology:DOID:10966); extrahepatic cholestasis (Disease Ontology:DOID:13619); B-cell lymphoma (Disease Ontology:DOID:707)", "pathway": " (mmu:16852); (R-MMU-381426); (R-MMU-8957275)", "pathway_count": 3, "publication_count": 20, "publication_id_list": "1638977;1986871;2025648;21750661;22645316;2335567;23806337;24788674;25153642;25428506;2803247;28135057;28528544;3020551;3335026;34428180;37507081;38105757;38254721;39927985", "class_list": "glycogene", "function": "DNA methylation of promoter region inhibits galectin-1 expression in BMSCs of aged mice., [RefSeq, PubMed]; Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. Plays a negative role in Th17 cell differentiation via activation of the receptor CD69., [UniProtKB, UniProtKB, PubMed]; Reduced form of Galectin-1 Suppresses Osteoclastic Differentiation of Human Peripheral Blood Mononuclear Cells and Murine RAW264 Cells In Vitro. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P05163;P11946;P17601;Q4FZH4;Q99M27;Q9D0X0", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0043236 laminin binding;GO:0030246 carbohydrate binding;GO:0048018 receptor ligand activity;GO:0030395 lactose binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0031295 T cell costimulation;GO:0010977 negative regulation of neuron projection development;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P16045-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000001.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKF1-1", "uniprot_id": [ { "id": "IQGA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JKF1", "type": "external" } ], "mass": 188742.0, "length": 1657, "protein_name": "Ras GTPase-activating-like protein IQGAP1", "gene_name": "Iqgap1", "organism": "Mouse", "refseq_name": "ras GTPase-activating-like protein IQGAP1", "refseq_ac": [ { "id": "NP_057930", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_057930", "type": "external" } ], "gene_names_uniprotkb": "Iqgap1", "gene_names_refseq": "D7Ertd237e; D7Ertd257e; Iqgap1; mKIAA0051", "protein_names_uniprotkb": "Ras GTPase-activating-like protein IQGAP1", "protein_names_refseq": "Cdc42-Rac1 effector protein; ras GTPase-activating-like protein IQGAP1", "tax_id": 10090, "disease": "", "pathway": " (mmu:29875); (R-MMU-373753); (R-MMU-5626467); (R-MMU-5674135); (R-MMU-6798695); (R-MMU-8980692); (R-MMU-9013106); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013406); (R-MMU-9013420); (R-MMU-9013424)", "pathway_count": 12, "publication_count": 27, "publication_id_list": "12377780;12900413;15592455;16968698;19956712;20484733;20883816;20951348;21750661;22645316;25153642;25605945;28089576;29125738;31219806;34428180;34887587;35601831;35820727;36210013;36792666;37507081;37828378;37913973;38791282;38944950;39627609", "class_list": "", "function": "Hippocampal circAnk3 Deficiency Causes Anxiety-like Behaviors and Social Deficits by Regulating the miR-7080-3p/IQGAP1 Pathway in Mice., [RefSeq, PubMed]; IQGAP1 Regulates Actin Polymerization and Contributes to Bleomycin-Induced Lung Fibrosis. Publication Status: Online-Only, [RefSeq, PubMed]; IQGAP1 domesticates macrophages to favor mycobacteria survival via modulating NF-kappaB signal and augmenting VEGF secretion., [RefSeq, PubMed]; IQGAP1 has a fundamental role in cell motility and invasion, [RefSeq, PubMed]; IQGAP1 is a potential target protein of S100B during processes of dynamic rearrangement of cell membrane morphology, [RefSeq, PubMed]; Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Recruited to the cell cortex by interaction with ILK which allows it to cooperate with its effector DIAPH1 to locally stabilize microtubules and allow stable insertion of caveolae into the plasma membrane (PubMed:20951348). Binds to activated CDC42 but does not stimulate its GTPase activity (PubMed:16968698). Associates with calmodulin. May promote neurite outgrowth. May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "G3UW45", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005096 GTPase activator activity;GO:0005516 calmodulin binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0016477 cell migration;GO:0032956 regulation of actin cytoskeleton organization;GO:0043410 positive regulation of MAPK cascade;GO:1900086 positive regulation of peptidyl-tyrosine autophosphorylation;GO:0071277 cellular response to calcium ion", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "Q9JKF1-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P85094-1", "uniprot_id": [ { "id": "ISC2A_MOUSE", "url": "https://www.uniprot.org/uniprot/P85094", "type": "external" } ], "mass": 22417.0, "length": 206, "protein_name": "Isochorismatase domain-containing protein 2A", "gene_name": "Isoc2a", "organism": "Mouse", "refseq_name": "isochorismatase domain-containing protein 2A precursor", "refseq_ac": [ { "id": "NP_001095068", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095068", "type": "external" } ], "gene_names_uniprotkb": "Isoc2a; Isoc2", "gene_names_refseq": "Isoc2a; Isoc2", "protein_names_uniprotkb": "Isochorismatase domain-containing protein 2A", "protein_names_refseq": "isochorismatase domain-containing protein 2A precursor; isochorismatase domain-containing protein 2A, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:664994)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "16916647;17658461;23576753;23806337;34428180;35820727;37453647;37507081;39927985", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0031648 protein destabilization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P85094-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6ZQF7-1", "uniprot_id": [ { "id": "JADE2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6ZQF7", "type": "external" } ], "mass": 92174.0, "length": 829, "protein_name": "E3 ubiquitin-protein ligase Jade-2", "gene_name": "Jade2", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase Jade-2 isoform 2", "refseq_ac": [ { "id": "NP_955003", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955003", "type": "external" } ], "gene_names_uniprotkb": "Jade2; Kiaa0239; Phf15", "gene_names_refseq": "1200017K05Rik; Jade2; Phf15; mKIAA0239", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase Jade-2; 2.3.2.27; Jade family PHD finger protein 2; PHD finger protein 15", "protein_names_refseq": "E3 ubiquitin-protein ligase Jade-2 isoform 2; E3 ubiquitin-protein ligase Jade-2; PHD finger protein 15; jade family PHD finger protein 2; protein Jade-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:76901); (R-MMU-3214847)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "14612400;21183079;21750661;23806337;25018020;34428180;36008159", "class_list": "", "function": "JADE2 Is Essential for Hippocampal Synaptic Plasticity and Cognitive Functions in Mice., [RefSeq, PubMed]; Results show that Jade-2 is a major LSD1 negative regulator during neurogenesis in vitro and in vivo in both mouse developing cerebral cortices and zebra fish embryos., [RefSeq, PubMed]; Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (By similarity). Acts as a E3 ubiquitin-protein ligase mediating the ubiquitination and subsequent proteasomal degradation of target protein histone demethylase KDM1A (PubMed:25018020). Also acts as a ubiquitin ligase E3 toward itself (PubMed:25018020). Positive regulator of neurogenesis (PubMed:25018020)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UHD5;Q6IE83", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0043997 histone H4K12 acetyltransferase activity;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0043995 histone H4K5 acetyltransferase activity;GO:0043996 histone H4K8 acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000123 histone acetyltransferase complex", "go_biological_process": "GO:2000278 regulation of DNA biosynthetic process;GO:0006338 chromatin remodeling;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0001558 regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6ZQF7-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QXX0-1", "uniprot_id": [ { "id": "JAG1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QXX0", "type": "external" } ], "mass": 134164.0, "length": 1218, "protein_name": "Protein jagged-1", "gene_name": "Jag1", "organism": "Mouse", "refseq_name": "protein jagged-1 precursor", "refseq_ac": [ { "id": "NP_038850", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038850", "type": "external" } ], "gene_names_uniprotkb": "Jag1", "gene_names_refseq": "ABE2; Gena228; Gsfabe2; Htu; Jag1; Ozz; Ser-1", "protein_names_uniprotkb": "Protein jagged-1; Jagged1", "protein_names_refseq": "Serrate-1; protein jagged-1 precursor; protein jagged-1", "tax_id": 10090, "disease": "chronic pancreatitis (Disease Ontology:DOID:0051065); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); dilated cardiomyopathy (Disease Ontology:DOID:12930); temporal arteritis (Disease Ontology:DOID:13375); congenital heart disease (Disease Ontology:DOID:1682); multiple sclerosis (Disease Ontology:DOID:2377); pulmonary fibrosis (Disease Ontology:DOID:3770); tetralogy of Fallot (Disease Ontology:DOID:6419); hepatocellular carcinoma (Disease Ontology:DOID:684); osteoarthritis (Disease Ontology:DOID:8398); Alagille syndrome (Disease Ontology:DOID:9245)", "pathway": " (mmu:16449); (R-MMU-9013149); (R-MMU-9013423); (R-MMU-9013507)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;10551863;10556292;30899004;32065591;34428180", "class_list": "", "function": "Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). May regulate fibroblast growth factor-induced angiogenesis., [UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 6, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 4, "disease_count": 11, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005543 phospholipid binding;GO:0005509 calcium ion binding;GO:0005112 Notch binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0045177 apical part of cell;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0042491 inner ear auditory receptor cell differentiation;GO:0072006 nephron development;GO:0072070 loop of Henle development;GO:0007219 Notch signaling pathway;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9QXX0-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32067-1", "uniprot_id": [ { "id": "LA_MOUSE", "url": "https://www.uniprot.org/uniprot/P32067", "type": "external" } ], "mass": 47756.0, "length": 415, "protein_name": "Lupus La protein homolog", "gene_name": "Ssb", "organism": "Mouse", "refseq_name": "lupus La protein homolog isoform a", "refseq_ac": [ { "id": "NP_001103615", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103615", "type": "external" } ], "gene_names_uniprotkb": "Ssb; Ss-b", "gene_names_refseq": "SS-B; Ssb", "protein_names_uniprotkb": "Lupus La protein homolog; La autoantigen homolog; La ribonucleoprotein", "protein_names_refseq": "La protein; Lupus LA protein homolog (LA ribonucleoprotein) (LA autoantigen homolog); Sjogren syndrome antigen B; autoantigen La; la autoantigen homolog; la ribonucleoprotein; lupus La protein homolog isoform a", "tax_id": 10090, "disease": "", "pathway": " (mmu:20823)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10671200;19950171;21750661;22645316;23806337;26495903;28223366;33300544;34428180;34723322;36288343;37453647;37507081;8454877;8920873", "class_list": "", "function": "Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation., [UniProtKB]; La deletion is associated with Neuron Death and Reactive Astrocytosis. Publication Status: Online-Only, [RefSeq, PubMed]; The lupus autoantigen La/Ssb is an Xist-binding protein involved in Xist folding and cloud formation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990825 sequence-specific mRNA binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0000049 tRNA binding;GO:0008266 poly(U) RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0010494 cytoplasmic stress granule;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:1903608 protein localization to cytoplasmic stress granule;GO:0075522 IRES-dependent viral translational initiation;GO:0006409 tRNA export from nucleus;GO:0008033 tRNA processing;GO:0045727 positive regulation of translation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P32067-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88487-1", "uniprot_id": [ { "id": "DC1I2_MOUSE", "url": "https://www.uniprot.org/uniprot/O88487", "type": "external" } ], "mass": 68394.0, "length": 612, "protein_name": "Cytoplasmic dynein 1 intermediate chain 2", "gene_name": "Dync1i2", "organism": "Mouse", "refseq_name": "cytoplasmic dynein 1 intermediate chain 2 isoform 5", "refseq_ac": [ { "id": "NP_001185805", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185805", "type": "external" } ], "gene_names_uniprotkb": "Dync1i2; Dnci2; Dncic2", "gene_names_refseq": "3110079H08Rik; Dncic2; Dync1i2", "protein_names_uniprotkb": "Cytoplasmic dynein 1 intermediate chain 2; Cytoplasmic dynein intermediate chain 2; DH IC-2; Dynein intermediate chain 2, cytosolic", "protein_names_refseq": "DH IC-2; cytoplasmic dynein 1 intermediate chain 2 isoform 5; cytoplasmic dynein 1 intermediate chain 2; dynein intermediate chain 2, cytosolic; dynein, cytoplasmic, intermediate chain 2", "tax_id": 10090, "disease": "autosomal recessive primary microcephaly (Disease Ontology:DOID:0070296)", "pathway": " (mmu:13427); (R-MMU-141430); (R-MMU-141444); (R-MMU-2132295); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-2565942); (R-MMU-3371497); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-5620912); (R-MMU-5663220); (R-MMU-6807878); (R-MMU-6811436); (R-MMU-68877); (R-MMU-8854518); (R-MMU-9646399); (R-MMU-9648025)", "pathway_count": 20, "publication_count": 12, "publication_id_list": "10049579;21183079;21750661;22956769;25605945;27474409;28619825;30084848;31219806;34428180;35820727;36288343", "class_list": "", "function": "Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function (By similarity). Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (By similarity). The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1 (PubMed:27474409). Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes (PubMed:27474409)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TGH7", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0045503 dynein light chain binding;GO:0045504 dynein heavy chain binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005874 microtubule;GO:0031982 vesicle;GO:0005868 cytoplasmic dynein complex;GO:0036157 outer dynein arm", "go_biological_process": "GO:0010977 negative regulation of neuron projection development;GO:0010970 transport along microtubule;GO:0007018 microtubule-based movement", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "O88487-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2I0-1", "uniprot_id": [ { "id": "LETM1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z2I0", "type": "external" } ], "mass": 82989.0, "length": 738, "protein_name": "Mitochondrial proton/calcium exchanger protein", "gene_name": "Letm1", "organism": "Mouse", "refseq_name": "mitochondrial proton/calcium exchanger protein precursor", "refseq_ac": [ { "id": "NP_062668", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062668", "type": "external" } ], "gene_names_uniprotkb": "Letm1", "gene_names_refseq": "KHE; Letm1", "protein_names_uniprotkb": "Mitochondrial proton/calcium exchanger protein; Electroneutral mitochondrial K(+)/H(+)exchanger; KHE; Leucine zipper-EF-hand-containing transmembrane protein 1", "protein_names_refseq": "LETM1 and EF-hand domain-containing protein 1, mitochondrial; electroneutral mitochondrial K(+)/H(+)exchanger; mitochondrial proton/calcium exchanger protein precursor; mitochondrial proton/calcium exchanger protein", "tax_id": 10090, "disease": "Wolf-Hirschhorn syndrome (Disease Ontology:DOID:0050460); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (mmu:56384); (R-MMU-9013408)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10486213;21750661;23716663;25077561;27669901;29123128;34428180;36288343;37453647;39927985", "class_list": "", "function": "Data indicate that cellular Letm1 knockdown reduced Ca(2+)mito uptake, H(+)mito extrusion and impaired mitochondrial ATP generation capacity., [RefSeq, PubMed]; Plays an important role in maintenance of mitochondrial morphology and in mediating either calcium or potassium/proton antiport (PubMed:23716663, PubMed:27669901). Mediates proton-dependent calcium efflux from mitochondrion (PubMed:23716663, PubMed:27669901). Functions also as an electroneutral mitochondrial proton/potassium exchanger (By similarity). Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain (By similarity). Required for the maintenance of the tubular shape and cristae organization (By similarity). Essential for early embryonic development (PubMed:23716663)., [UniProtKB, PubMed, UniProtKB, PubMed]; Reconstitution of LETM1 or antioxidant overexpression rescued mitochondrial Ca(2+) transport and bioenergetics Erratum:[FASEB J. 2015 Aug;29(8):3593. doi: 10.1096/fj.14-256453ERR. PMID: 26232296], [RefSeq, PubMed]; This paper's findings delineate a mechanism by which PINK1 regulates mitochondrial Ca(2+) level through LETM1 and suggest a model by which PINK1 loss leads to deficient phosphorylation of LETM1 and impaired mitochondrial Ca(2+) transport. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5PQC5;Q7TMK8;Q80ZX6;Q8CGJ3;Q8K5E5", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0043022 ribosome binding;GO:0015369 calcium:proton antiporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0051562 negative regulation of mitochondrial calcium ion concentration;GO:0051260 protein homooligomerization;GO:0006816 calcium ion transport;GO:0007005 mitochondrion organization;GO:0006851 mitochondrial calcium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9Z2I0-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QX11-1", "uniprot_id": [ { "id": "CYH1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QX11", "type": "external" } ], "mass": 46274.0, "length": 398, "protein_name": "Cytohesin-1", "gene_name": "Cyth1", "organism": "Mouse", "refseq_name": "cytohesin-1 isoform 2", "refseq_ac": [ { "id": "NP_001106169", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106169", "type": "external" } ], "gene_names_uniprotkb": "Cyth1; Pscd1", "gene_names_refseq": "CLM1; CTH-1; CYTIP; Cyth1; Pscd1", "protein_names_uniprotkb": "Cytohesin-1; CLM1; PH, SEC7 and coiled-coil domain-containing protein 1; SEC7 homolog A; mSec7-1", "protein_names_refseq": "PH, SEC7 and coiled-coil domain-containing protein 1; SEC7 homolog A; cytohesin-1 isoform 2; mSec7-1; pleckstrin homology, Sec7 and coiled-coil domains 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:19157); (R-MMU-6811438)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10978522;18042453;20080746;21750661;23012656;29420262;38858421;9744817;9745014", "class_list": "", "function": "A natural loss-of-function deletion of the cytohesin 1 (Cyth1) gene in BALB/cByJ mice does not impact cardiomyocyte polyploidy. Publication Status: Online-Only, [RefSeq, PubMed]; Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6 (PubMed:18042453, PubMed:20080746). Promotes the activation of ARF factors through replacement of GDP with GTP (PubMed:18042453). Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization, through regulation of ARF6 activity (PubMed:20080746, PubMed:29420262)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88817;Q76MU4", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0098888 extrinsic component of presynaptic membrane;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0005923 bicellular tight junction", "go_biological_process": "GO:0016192 vesicle-mediated transport;GO:0090162 establishment of epithelial cell polarity;GO:0032012 regulation of ARF protein signal transduction;GO:0099171 presynaptic modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9QX11-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55200-1", "uniprot_id": [ { "id": "KMT2A_MOUSE", "url": "https://www.uniprot.org/uniprot/P55200", "type": "external" } ], "mass": 429649.0, "length": 3966, "protein_name": "Histone-lysine N-methyltransferase 2A", "gene_name": "Kmt2a", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Kmt2a; All1; Hrx; Mll1; Mll", "gene_names_refseq": "", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase 2A; 2.1.1.-; 2.1.1.364; ALL-1; C-terminal cleavage product of 180 kDa; Cysteine methyltransferase KMT2A; Lysine N-methyltransferase 2A; Myeloid/lymphoid or mixed-lineage leukemia protein 1; Myeloid/lymphoid or mixed-lineage leukemia; N-terminal cleavage product of 320 kDa; Zinc finger protein HRX; p180; p320", "protein_names_refseq": "", "tax_id": 10090, "disease": "non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); prostate cancer (Disease Ontology:DOID:10283); congenital heart disease (Disease Ontology:DOID:1682); transient cerebral ischemia (Disease Ontology:DOID:224); cervical cancer (Disease Ontology:DOID:4362); myelofibrosis (Disease Ontology:DOID:4971); acute myeloid leukemia (Disease Ontology:DOID:9119); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (R-MMU-3214841); (R-MMU-8936459); (R-MMU-8939236); (R-MMU-9772755)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;21113167;21183079;21335234;21750661;22872234;23806337;31219806;34428180;35820727;36852467;40997131;8327517", "class_list": "", "function": "Histone methyltransferase that plays an essential role in early development and hematopoiesis (By similarity). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (By similarity). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (By similarity). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (By similarity). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (By similarity). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (By similarity). Required for transcriptional activation of HOXA9 (By similarity). Promotes PPP1R15A-induced apoptosis (By similarity). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (PubMed:21113167). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (PubMed:21113167). Also has auto-methylation activity on Cys-3879 in absence of histone H3 substrate (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 24, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 8, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "E9QNE7;Q3UEU1;Q3USE7", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.37", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.370", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.370", "type": "external" }, { "id": "2.1.1.371", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.371", "type": "external" }, { "id": "3.4.25.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.-", "type": "external" }, { "id": "2.1.1.85", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.85", "type": "external" }, { "id": "2.1.1.359", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359", "type": "external" }, { "id": "2.1.1.355", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355", "type": "external" }, { "id": "2.1.1.354", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354", "type": "external" }, { "id": "2.1.1.362", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.362", "type": "external" }, { "id": "2.1.1.361", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.361", "type": "external" }, { "id": "2.3.1.57", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.57", "type": "external" }, { "id": "2.1.1.319", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.319", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0035097 histone methyltransferase complex;GO:0071339 MLL1 complex", "go_biological_process": "GO:0035162 embryonic hemopoiesis;GO:0048172 regulation of short-term neuronal synaptic plasticity;GO:0008285 negative regulation of cell population proliferation;GO:0008542 visual learning;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P55200-1", "record_type": "protein", "filter_code": "0000000.1000111.001000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91VH6-1", "uniprot_id": [ { "id": "MEMO1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91VH6", "type": "external" } ], "mass": 33692.0, "length": 297, "protein_name": "Protein MEMO1", "gene_name": "Memo1", "organism": "Mouse", "refseq_name": "protein MEMO1", "refseq_ac": [ { "id": "NP_598532", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598532", "type": "external" } ], "gene_names_uniprotkb": "Memo1", "gene_names_refseq": "0610016J10Rik; D930048L02Rik; Memo1", "protein_names_uniprotkb": "Protein MEMO1; Mediator of ErbB2-driven cell motility 1; Memo-1", "protein_names_refseq": "mediator of ErbB2-driven cell motility 1; memo-1; protein MEMO1; protein memo", "tax_id": 10090, "disease": "", "pathway": " (mmu:76890); (R-MMU-6785631)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "11707072;17077023;17947660;21750661;25605945;31219806;32706793;34428180;36967231", "class_list": "", "function": "Elevated serum magnesium lowers calcification propensity in Memo1-deficient mice. Publication Status: Online-Only, [RefSeq, PubMed]; FGFR regulator Memo1 is dispensable for FGF23 expression by osteoblasts during folic acid-driven kidney injury., [RefSeq, PubMed]; May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Tissue distribution of Memo in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042277 peptide binding", "go_cellular_component": "", "go_biological_process": "GO:0032886 regulation of microtubule-based process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q91VH6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JM54-1", "uniprot_id": [ { "id": "APR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JM54", "type": "external" } ], "mass": 11566.0, "length": 103, "protein_name": "Phorbol-12-myristate-13-acetate-induced protein 1", "gene_name": "Pmaip1", "organism": "Mouse", "refseq_name": "phorbol-12-myristate-13-acetate-induced protein 1", "refseq_ac": [ { "id": "NP_067426", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067426", "type": "external" } ], "gene_names_uniprotkb": "Pmaip1; Noxa", "gene_names_refseq": "Noxa; Pmaip1", "protein_names_uniprotkb": "Phorbol-12-myristate-13-acetate-induced protein 1; Protein Noxa", "protein_names_refseq": "phorbol-12-myristate-13-acetate-induced protein 1; protein Noxa", "tax_id": 10090, "disease": "", "pathway": " (mmu:58801); (R-MMU-111448); (R-MMU-111453)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "10807576;12952892;14500851;15694340;15901672;16822983;17389404;20484733;21750661;25428506;30084848;30779550;36210013;38489392", "class_list": "", "function": "Noxa(-/-) mice showed resistance to X-ray irradiation-induced gastrointestinal death, accompanied with impaired apoptosis., [RefSeq, PubMed]; P53 and BCL-2 family proteins PUMA and NOXA define competitive fitness in pluripotent cell competition. Publication Status: Online-Only, [RefSeq, PubMed]; Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1 (By similarity). Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Puma and Noxa are critical mediators of the apoptotic responses induced by p53 and other agents, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0097136 Bcl-2 family protein complex", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0051607 defense response to virus;GO:0006915 apoptotic process;GO:0006974 DNA damage response;GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9JM54-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60720-1", "uniprot_id": [ { "id": "CY561_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60720", "type": "external" } ], "mass": 27822.0, "length": 250, "protein_name": "Transmembrane ascorbate-dependent reductase CYB561", "gene_name": "Cyb561", "organism": "Mouse", "refseq_name": "transmembrane ascorbate-dependent reductase CYB561 isoform 1", "refseq_ac": [ { "id": "NP_031831", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031831", "type": "external" } ], "gene_names_uniprotkb": "Cyb561; Mcyt", "gene_names_refseq": "Cyb561", "protein_names_uniprotkb": "Transmembrane ascorbate-dependent reductase CYB561; 7.2.1.3; CGCytb; Chromaffin granule Cyt b561; Cytochrome b-561; Cytochrome b561", "protein_names_refseq": "CGCytb; chromaffin granule Cyt b561; cytochrome b561; transmembrane ascorbate-dependent reductase CYB561 isoform 1; transmembrane ascorbate-dependent reductase CYB561", "tax_id": 10090, "disease": "", "pathway": " (mmu:13056)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14499595;16256064;21183079;21750661;29343526;9778036", "class_list": "", "function": "Data show that four members of the b561 family of predicted ferric reductases: mouse cytochrome b561, human duodenal cytochrome b, and mouse stromal cell-derived receptor 2, have ferric reductase activity., [RefSeq, PubMed]; Transmembrane reductase that probably uses ascorbate as an electron donor to reduce Fe(3+) into Fe(2+) and could play a role in iron transport (PubMed:14499595). It is also able to reduce extracellular monodehydro-L-ascorbate and could be involved in the regeneration and homeostasis within secretory vesicles of ascorbate which in turn provides reducing equivalents needed to support the activity of intravesicular enzymes (PubMed:16256064)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TEC6;Q9D6C9", "ec_number_list": [ { "id": "7.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.1.3", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0016491 oxidoreductase activity;GO:0140575 transmembrane monodehydroascorbate reductase activity;GO:0140571 transmembrane ascorbate ferrireductase activity", "go_cellular_component": "GO:0005765 lysosomal membrane;GO:0042584 chromaffin granule membrane", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis;GO:0140576 ascorbate homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q60720-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q812E0-1", "uniprot_id": [ { "id": "CPEB2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q812E0", "type": "external" } ], "mass": 58442.0, "length": 521, "protein_name": "Cytoplasmic polyadenylation element-binding protein 2", "gene_name": "Cpeb2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cpeb2", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytoplasmic polyadenylation element-binding protein 2; CPE-BP2; CPE-binding protein 2; mCPEB-2", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:231207)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;12672660;12871996;17927953;21183079;21750661;30084848;34428180", "class_list": "", "function": "May play a role in translational regulation of stored mRNAs in transcriptionally inactive haploid spermatids. Binds to poly(U) RNA oligomers (PubMed:12672660). Required for cell cycle progression, specifically for the transition from metaphase to anaphase (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9343, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity;GO:0005095 GTPase inhibitor activity;GO:0043024 ribosomal small subunit binding;GO:0008135 translation factor activity, RNA binding;GO:0043022 ribosome binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0045202 synapse;GO:0043005 neuron projection", "go_biological_process": "GO:0032869 cellular response to insulin stimulus;GO:0071456 cellular response to hypoxia;GO:0045900 negative regulation of translational elongation;GO:1900248 negative regulation of cytoplasmic translational elongation;GO:2000766 negative regulation of cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q812E0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R368-1", "uniprot_id": [ { "id": "DAAF4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R368", "type": "external" } ], "mass": 48125.0, "length": 420, "protein_name": "Dynein axonemal assembly factor 4", "gene_name": "Dnaaf4", "organism": "Mouse", "refseq_name": "dynein axonemal assembly factor 4 isoform 1", "refseq_ac": [ { "id": "NP_080590", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080590", "type": "external" } ], "gene_names_uniprotkb": "Dnaaf4; Dyx1c1; Ekn1", "gene_names_refseq": "1700010I24Rik; Dnaaf4; Dyx1c1; EKN1; b2b811.1Clo; b2b811Clo", "protein_names_uniprotkb": "Dynein axonemal assembly factor 4; Dyslexia susceptibility 1 candidate gene 1 protein homolog", "protein_names_refseq": "dynein assembly factor 4, axonemal; dynein axonemal assembly factor 4 isoform 1; dyslexia susceptibility 1 candidate 1 homolog; dyslexia susceptibility 1 candidate gene 1 protein homolog", "tax_id": 10090, "disease": "Robinow syndrome (Disease Ontology:DOID:0060254); primary ciliary dyskinesia 25 (Disease Ontology:DOID:0110615); sensorineural hearing loss (Disease Ontology:DOID:10003); dyslexia (Disease Ontology:DOID:4428)", "pathway": " (mmu:67685)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;23872636;25428506;25989970;29201552;31219806", "class_list": "", "function": "DYX1C1 is required for axonemal dynein assembly and ciliary motility., [RefSeq, PubMed]; Findings in mice affirm existing evidence that DYX1C1 may play an underlying role in the development of neural systems important to learning and memory, and disruption of this function could contribute to the learning deficits seen in individuals with dyslexia, [RefSeq, PubMed]; In total, four independent SNPs within DYX1C1 and ATP2C2 were found to be associated with MMR stronger than expected from multiple testing. To explore potential pathomechanisms, we annotated these variants with functional data including tissue-specific expression analysis and eQTLs. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity (By similarity). Axonemal dynein assembly factor required for ciliary motility., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3X916", "ec_number_list": [], "go_molecular_function": "GO:0030331 nuclear estrogen receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0007507 heart development;GO:0007611 learning or memory;GO:0001764 neuron migration;GO:0007368 determination of left/right symmetry", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8R368-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SQX6-1", "uniprot_id": [ { "id": "CYFP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5SQX6", "type": "external" } ], "mass": 145659.0, "length": 1253, "protein_name": "Cytoplasmic FMR1-interacting protein 2", "gene_name": "Cyfip2", "organism": "Mouse", "refseq_name": "cytoplasmic FMR1-interacting protein 2", "refseq_ac": [ { "id": "NP_001239388", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239388", "type": "external" } ], "gene_names_uniprotkb": "Cyfip2; Kiaa1168; Pir121", "gene_names_refseq": "1500004I01Rik; 6430511D02Rik; Cyfip2; Pir121; mKIAA1168", "protein_names_uniprotkb": "Cytoplasmic FMR1-interacting protein 2; p53-inducible protein 121", "protein_names_refseq": "cytoplasmic FMR1-interacting protein 2; p53-inducible protein 121", "tax_id": 10090, "disease": "chromosome 15q11.2 deletion syndrome (Disease Ontology:DOID:0060393); developmental and epileptic encephalopathy 65 (Disease Ontology:DOID:0080430)", "pathway": " (mmu:76884); (R-MMU-2029482); (R-MMU-4420097); (R-MMU-5663213); (R-MMU-9013149)", "pathway_count": 5, "publication_count": 24, "publication_id_list": "10.1101/2023.09.13.557529;10449408;11438699;15731336;21750661;22517741;22645316;24153177;25428506;25605945;26740625;27605705;30084848;30779550;30899004;31219806;32848054;33300544;34203471;34428180;35822049;36210013;39627609;40885482", "class_list": "", "function": "Part of the WAVE1 complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). Involved in T-cell adhesion and p53-dependent induction of apoptosis (By similarity). Does not bind RNA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (PubMed:27605705)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3UH21;Q3UHS8;Q8BSW0;Q8CHA9;Q924D3;Q9R181", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0031175 neuron projection development;GO:0006915 apoptotic process;GO:0000902 cell morphogenesis;GO:0098609 cell-cell adhesion;GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "Q5SQX6-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62165-1", "uniprot_id": [ { "id": "DAG1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62165", "type": "external" } ], "mass": 96905.0, "length": 893, "protein_name": "Dystroglycan 1", "gene_name": "Dag1", "organism": "Mouse", "refseq_name": "dystroglycan 1 preproprotein", "refseq_ac": [ { "id": "NP_001263410", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263410", "type": "external" } ], "gene_names_uniprotkb": "Dag1", "gene_names_refseq": "D9Wsu13e; DG; Dag1; Dp427; Dp71", "protein_names_uniprotkb": "Dystroglycan 1; Dystroglycan; Dystrophin-associated glycoprotein 1", "protein_names_refseq": "dystroglycan 1 preproprotein; dystrophin associated glycoprotein 1", "tax_id": 10090, "disease": "lissencephaly (Disease Ontology:DOID:0050453); Fukuyama congenital muscular dystrophy (Disease Ontology:DOID:0050559); muscular dystrophy-dystroglycanopathy type B1 (Disease Ontology:DOID:0050588); autosomal recessive limb-girdle muscular dystrophy type 2D (Disease Ontology:DOID:0110278); autosomal recessive limb-girdle muscular dystrophy type 2P (Disease Ontology:DOID:0110293); congenital muscular dystrophy-dystroglycanopathy type A9 (Disease Ontology:DOID:0111232); muscular dystrophy-dystroglycanopathy (Disease Ontology:DOID:0112374); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); primary biliary cholangitis (Disease Ontology:DOID:12236); dilated cardiomyopathy (Disease Ontology:DOID:12930); inclusion body myositis (Disease Ontology:DOID:3429); myocardial infarction (Disease Ontology:DOID:5844); muscular atrophy (Disease Ontology:DOID:767); type 2 diabetes mellitus (Disease Ontology:DOID:9352); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (mmu:13138); (R-MMU-8932504); (R-MMU-8932505); (R-MMU-8932506); (R-MMU-9010553); (R-MMU-9913351); (R-MMU-9939291)", "pathway_count": 7, "publication_count": 40, "publication_id_list": "10.1101/2023.09.13.557529;10022829;10366602;11157973;11430802;11495720;11798066;12402286;12670716;12797959;12843252;15326183;16075062;16098969;16475793;16531403;16709410;18641643;19109891;20044576;21183079;21750661;25757569;26495903;30899004;31599954;33300544;34428180;36852467;37507081;37828378;40473926;40885482;7833916;8872465;9057818;9175728;9454835;9864373;9917844", "class_list": "glycogene", "function": "Extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains, and for certain adenoviruses. As a receptor for laminin is involved in extracellular matrix assembly, and activation of the PI3K/AKT pathway regulating cell apoptotic signals in muscle (PubMed:10366602, PubMed:12402286). Binding of laminin LAMA1 to alpha-dystroglycan also activates RAC1 signaling (PubMed:16475793). This process involves a signaling cascade in which Src kinases, c-Src or c-Fyn, phosphorylate syntrophin modifying its interaction with the adapter protein GRB2; this triggers recruitment of guanyl-nucleotide exchange factor SOS1 and activation of RAC1, finally resulting in c-Jun phosphorylation by MAPK8/JNK1 (By similarity). As a receptor for laminin LAMA1 is also involved in epithelium branching morphogenesis in salivary glang and lung (PubMed:11798066). Receptor for laminin-2 (LAMA2) and agrin in peripheral nerve Schwann cells (By similarity). Also acts as a receptor for laminin LAMA5 (By similarity) (PubMed:10366602, PubMed:11798066, PubMed:12402286). In muscle cells, it is a receptor for laminin-1 (also known as laminin-111 or EHS laminin) and is involved in the stimulation of agrin-induced acetylcholine receptor (AChR) clustering, and formation of the synaptic basement membrane (PubMed:16531403, PubMed:9454835, PubMed:11157973). It is required for acetylcholinesterase (AChE) localization at the neuromuscular junctions (NMJ) through its binding with perlecan (HSPG2) and is, therefore, involved in the down-regulation of colinergic synaptic transmission (PubMed:11157973). In the retina, it is required for the formation of photoreceptor ribbon synapses through its interaction with pikachurin (EGFLAM) (PubMed:18641643). Also involved in the positive regulation of cartilage formation through agrin (AGRN) binding and up-regulation of SOX9, a transcription factor that plays a key role in chondrocytes differentiation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The dystroglycan complex is involved in a number of signaling events and processes including laminin deposition and extracellular matrix assembly, acetylcholine receptor (AChR) clustering, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, epithelial polarization, and epithelium branching morphogenesis. Required for the formation of photoreceptor ribbon synapses, and long-term maintenance of inhibitory synapses in cerebellar Purkinje cells (PubMed:18641643, PubMed:40473926). Also involved in the positive regulation of cartilage formation through agrin (AGRN) binding and up-regulation of SOX9, a transcription factor that plays a key role in chondrocytes differentiation (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes dystroglycan, a central component of dystrophin-glycoprotein complex that links the extracellular matrix and the cytoskeleton in the skeletal muscle. The encoded preproprotein undergoes O- and N-glycosylation, and proteolytic processing to generate alpha and beta subunits. A complete lack of the encoded protein in mice results in embryonic lethality due to the disorganization of Reichert's membrane. Chimeric mice deficient in the encoded protein overcome embryonic lethality but develop a progressive muscular dystrophy. Alternative splicing results in multiple transcript variants, all encoding the same protein. [provided by RefSeq, Nov 2015]., [RefSeq]; Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity (By similarity)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 32, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 7, "disease_count": 16, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "Q61094;Q61141;Q61497", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0004252 serine-type endopeptidase activity;GO:0042802 identical protein binding;GO:0043395 heparan sulfate proteoglycan binding;GO:0051393 alpha-actinin binding", "go_cellular_component": "GO:0016010 dystrophin-associated glycoprotein complex;GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0043403 skeletal muscle tissue regeneration;GO:0098942 retrograde trans-synaptic signaling by trans-synaptic protein complex;GO:0085029 extracellular matrix assembly;GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering;GO:0006509 membrane protein ectodomain proteolysis", "synthesized_glycan_count": 0, "hit_score": 5.4, "record_id": "Q62165-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000001001.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KN98-1", "uniprot_id": [ { "id": "CYTSA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q2KN98", "type": "external" } ], "mass": 124488.0, "length": 1118, "protein_name": "Cytospin-A", "gene_name": "Specc1l", "organism": "Mouse", "refseq_name": "cytospin-A isoform a", "refseq_ac": [ { "id": "NP_001139298", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139298", "type": "external" } ], "gene_names_uniprotkb": "Specc1l; Cytsa; Kiaa0376", "gene_names_refseq": "4930470P14Rik; 4932439K10Rik; 9530057A13Rik; Cytsa; Specc1l; mKIAA0376", "protein_names_uniprotkb": "Cytospin-A; SPECC1-like protein; Sperm antigen with calponin homology and coiled-coil domains 1-like", "protein_names_refseq": "SPECC1-like protein; cytospin-A isoform a; cytospin-A", "tax_id": 10090, "disease": "orofacial cleft (Disease Ontology:DOID:0050567); Teebi hypertelorism syndrome 1 (Disease Ontology:DOID:0080698); oblique facial clefting 1 (Disease Ontology:DOID:0111706); cleft palate (Disease Ontology:DOID:674)", "pathway": " (mmu:74392)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;17242355;21183079;21703590;21750661;25428506;26787558;31219806;34203471;34302166;34428180;34887587;37345651", "class_list": "", "function": "In-frame deletion of SPECC1L microtubule association domain results in gain-of-function phenotypes affecting embryonic tissue movement and fusion events., [RefSeq, PubMed]; Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; SPECC1L as a novel modulator of PI3K-AKT signaling and AJ biology, required for neural tube closure and CNCC delamination. Publication Status: Online-Only, [RefSeq, PubMed]; SPECC1L: a cytoskeletal protein that regulates embryonic tissue dynamics., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8CHF9", "ec_number_list": [], "go_molecular_function": "GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005819 spindle;GO:0005911 cell-cell junction;GO:0015629 actin cytoskeleton;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0030835 negative regulation of actin filament depolymerization;GO:0007155 cell adhesion;GO:0016477 cell migration;GO:0051301 cell division;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q2KN98-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AKB9-1", "uniprot_id": [ { "id": "DCA10_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AKB9", "type": "external" } ], "mass": 61558.0, "length": 566, "protein_name": "DDB1- and CUL4-associated factor 10", "gene_name": "Dcaf10", "organism": "Mouse", "refseq_name": "DDB1- and CUL4-associated factor 10", "refseq_ac": [ { "id": "NP_694807", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694807", "type": "external" } ], "gene_names_uniprotkb": "Dcaf10; Wdr32", "gene_names_refseq": "Dcaf10; Wdr32", "protein_names_uniprotkb": "DDB1- and CUL4-associated factor 10; WD repeat-containing protein 32", "protein_names_refseq": "DDB1- and CUL4-associated factor 10; WD repeat domain 32; WD repeat-containing protein 32", "tax_id": 10090, "disease": "", "pathway": " (mmu:242418); (R-MMU-8951664)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "20484733;21183079;21750661;22872234;24129315;25428506;30016717;30084848;30779550;31219806;31361958;31599954;34203471;34428180;35820727", "class_list": "", "function": "May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A2AKV8;Q3TNI7;Q5U4G6;Q8BHQ2;Q8BHS1;Q8BHX4;Q8K3A5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0080008 Cul4-RING E3 ubiquitin ligase complex", "go_biological_process": "GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "A2AKB9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48318-1", "uniprot_id": [ { "id": "DCE1_MOUSE", "url": "https://www.uniprot.org/uniprot/P48318", "type": "external" } ], "mass": 66648.0, "length": 593, "protein_name": "Glutamate decarboxylase 1", "gene_name": "Gad1", "organism": "Mouse", "refseq_name": "glutamate decarboxylase 1 isoform GAD67", "refseq_ac": [ { "id": "NP_032103", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032103", "type": "external" } ], "gene_names_uniprotkb": "Gad1; Gad67", "gene_names_refseq": "EP10; Gad-1; Gad1", "protein_names_uniprotkb": "Glutamate decarboxylase 1; 4.1.1.15; 67 kDa glutamic acid decarboxylase; GAD-67; Glutamate decarboxylase 67 kDa isoform", "protein_names_refseq": "67 kDa glutamic acid decarboxylase; glutamate decarboxylase 1 isoform GAD67; glutamic acid decarboxylase 1", "tax_id": 10090, "disease": "spastic cerebral palsy (Disease Ontology:DOID:0050669); alcohol dependence (Disease Ontology:DOID:0050741); withdrawal disorder (Disease Ontology:DOID:0060001); autism spectrum disorder (Disease Ontology:DOID:0060041); developmental and epileptic encephalopathy 89 (Disease Ontology:DOID:0112223); alcohol use disorder (Disease Ontology:DOID:1574); drug psychosis (Disease Ontology:DOID:1742); epilepsy (Disease Ontology:DOID:1826); anxiety disorder (Disease Ontology:DOID:2030); transient cerebral ischemia (Disease Ontology:DOID:224); morphine dependence (Disease Ontology:DOID:2560); bipolar disorder (Disease Ontology:DOID:3312); schizophrenia (Disease Ontology:DOID:5419); amphetamine abuse (Disease Ontology:DOID:670); colorectal cancer (Disease Ontology:DOID:9256); diabetes mellitus (Disease Ontology:DOID:9351); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:14415); (R-MMU-888568); (R-MMU-888590)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;10556546;11471062;12106047;21183079;21750661;33300544;8243324;9177246", "class_list": "", "function": "Catalyzes the synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) with pyridoxal 5'-phosphate as cofactor., [UniProtKB, PubMed, UniProtKB, UniProtKB]; The protein encoded by this gene is an enzyme that catalyzes the production of gamma-aminobutyric acid from L-glutamic acid. Alternative splicing of this gene results in three products, the predominant 67 kDa isoform, a smaller 25 kDa isoform, and an even smaller 49 aa isoform. The two shorter isoforms are not thought to retain catalytic activity. [provided by RefSeq, Apr 2023]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 17, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O08685", "ec_number_list": [ { "id": "4.1.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.15", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0004351 glutamate decarboxylase activity;GO:0016595 glutamate binding", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005938 cell cortex;GO:0030424 axon", "go_biological_process": "GO:0090326 positive regulation of locomotion involved in locomotory behavior;GO:0035176 social behavior;GO:0035641 locomotory exploration behavior;GO:0006538 L-glutamate catabolic process;GO:0009449 gamma-aminobutyric acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P48318-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q71M36-1", "uniprot_id": [ { "id": "CSPG5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q71M36", "type": "external" } ], "mass": 60406.0, "length": 566, "protein_name": "Chondroitin sulfate proteoglycan 5", "gene_name": "Cspg5", "organism": "Mouse", "refseq_name": "chondroitin sulfate proteoglycan 5 isoform b precursor", "refseq_ac": [ { "id": "NP_001159745", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159745", "type": "external" } ], "gene_names_uniprotkb": "Cspg5; Caleb; Ngc", "gene_names_refseq": "Caleb; Cspg5; Ngc", "protein_names_uniprotkb": "Chondroitin sulfate proteoglycan 5; Acidic leucine-rich EGF-like domain-containing brain protein; Neuroglycan C", "protein_names_refseq": "acidic leucine-rich EGF-like domain-containing brain protein; chondroitin sulfate proteoglycan 5 isoform b precursor; neuroglycan C", "tax_id": 10090, "disease": "", "pathway": " (mmu:29873); (R-MMU-1971475); (R-MMU-2022870); (R-MMU-2022923); (R-MMU-2024101)", "pathway_count": 5, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;10617623;11069908;11929867;12885772;15331613;15848802;21183079;23889129;24265546;30899004;33300544;9950058", "class_list": "glycogene", "function": "CALEB is transiently required for synapse maturation in the cerebellum., [RefSeq, PubMed]; Despite the previously reported upregulation of Cspg5 during retinal degeneration in Rpe65/ mice, no protective effect or any involvement of Cspg5 in disease progression was identified. Publication Status: Online-Only, [RefSeq, PubMed]; May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation., [UniProtKB, PubMed]; Phosphorylation and localization in lipid rafts, [RefSeq, PubMed]; This gene encodes a chondroitin sulfate proteoglycan. The encoded protein has been termed a 'part-time' proteoglycan, as chondroitin sulfate chains appear to be attached to the protein in the developing but not the adult cerebellum and retina. It is thought that this protein plays roles in dendrite branching and synapse formation. [provided by RefSeq, Oct 2009]., [RefSeq]", "predicted_glycosites": 11, "predicted_n_glycosites": 1, "predicted_o_glycosites": 10, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 0, "mined_o_glycosites": 1, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 20, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 8, "disease_count": 0, "glyco_site_count": 15, "binding_glycan_count": 0, "secondary_ac_list": "E9QN54;Q71M37;Q7TNT8;Q8BPJ5;Q9QY32", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0007010 cytoskeleton organization;GO:1900026 positive regulation of substrate adhesion-dependent cell spreading;GO:0050804 modulation of chemical synaptic transmission;GO:0031103 axon regeneration;GO:2000300 regulation of synaptic vesicle exocytosis", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q71M36-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.1100010011001.111.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80Y98-1", "uniprot_id": [ { "id": "DDHD2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80Y98", "type": "external" } ], "mass": 79577.0, "length": 699, "protein_name": "Triacylglycerol hydrolase DDHD2", "gene_name": "Ddhd2", "organism": "Mouse", "refseq_name": "triacylglycerol hydrolase DDHD2 isoform 1", "refseq_ac": [ { "id": "NP_082378", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082378", "type": "external" } ], "gene_names_uniprotkb": "Ddhd2; Kiaa0725; Samwd1", "gene_names_refseq": "2010305K11Rik; Ddhd2; SAMWD1; mKIAA0725", "protein_names_uniprotkb": "Triacylglycerol hydrolase DDHD2; 3.1.1.-; 3.1.1.3; DDHD domain-containing protein 2; Phospholipase DDHD2; SAM, WWE and DDHD domain-containing protein 1; TAG hydrolase; Triglyceride hydrolase DDHD2; Triglyceride lipase", "protein_names_refseq": "DDHD domain-containing protein 2; Phospholipase DDHD2; SAM, WWE and DDHD domain-containing protein 1; TAG hydrolase; triacylglycerol hydrolase DDHD2 isoform 1; triacylglycerol hydrolase DDHD2; triglyceride hydrolase DDHD2; triglyceride lipase", "tax_id": 10090, "disease": "hereditary spastic paraplegia 28 (Disease Ontology:DOID:0110779); hereditary spastic paraplegia 54 (Disease Ontology:DOID:0110806); hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (mmu:72108); (R-MMU-1483166)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "20665223;21183079;21750661;25267624;31219806;37828378;37832604;38316990;39062593", "class_list": "", "function": "DDHD2(-/-) mice show age-dependent triacylglycerol elevations in the central nervous system, but not in several peripheral tissues., [RefSeq, PubMed]; Diacylglycerol (DAG) and triacylglycerol (TAG) lipase that is required for proper lipid homeostasis in the central nervous system (PubMed:25267624, PubMed:37832604). It cooperates with PNPLA2/ATGL in neuronal TAG catabolism and hydrolyzes sn-1,3-DAG downstream of PNPLA2/ATGL (PubMed:37832604). In vitro, also acts as a phospholipase that hydrolyzes preferentially phosphatidic acids, including 1,2-dioleoyl-sn-phosphatidic acid, phosphatidylcholine and phosphatidylethanolamine. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P), phosphatidylinositol 5-phosphate (PI(5)P) and possibly phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). May be involved in the maintenance of the endoplasmic reticulum and/or Golgi structures. May regulate the transport between Golgi apparatus and plasma membrane (By similarity)., [UniProtKB, PubMed, PubMed]; Radiation-Induced Endothelial Ferroptosis Accelerates Atherosclerosis via the DDHD2-Mediated Nrf2/GPX4 Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; The DDHD2-STXBP1 interaction mediates long-term memory via generation of saturated free fatty acids., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QKK2;Q0VF66;Q6A008;Q9CVE9", "ec_number_list": [ { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.34", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.26", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.111", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.111", "type": "external" }, { "id": "3.1.1.118", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.118", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.1.116", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.116", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004620 phospholipase activity;GO:0004806 triacylglycerol lipase activity;GO:0120516 diacylglycerol lipase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0016020 membrane;GO:0030134 COPII-coated ER to Golgi transport vesicle", "go_biological_process": "GO:0007626 locomotory behavior;GO:0008542 visual learning;GO:0019433 triglyceride catabolic process;GO:0034389 lipid droplet organization;GO:0090141 positive regulation of mitochondrial fission", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q80Y98-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BQU6-1", "uniprot_id": [ { "id": "CXG2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BQU6", "type": "external" } ], "mass": 47008.0, "length": 440, "protein_name": "Gap junction gamma-2 protein", "gene_name": "Gjc2", "organism": "Mouse", "refseq_name": "gap junction gamma-2 protein", "refseq_ac": [ { "id": "NP_536702", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_536702", "type": "external" } ], "gene_names_uniprotkb": "Gjc2; Gja12", "gene_names_refseq": "B230382L12Rik; Cx47; Cxno; Gja12; Gjc2", "protein_names_uniprotkb": "Gap junction gamma-2 protein; Connexin-47; Cx47; Gap junction alpha-12 protein", "protein_names_refseq": "connexin 47 type A; connexin 47 type C; connexin 47 type D; connexin o; connexin-47; gap junction alpha-12 protein; gap junction gamma-2 protein; gap junction membrane channel protein alpha 12; gap junction protein, chi 2", "tax_id": 10090, "disease": "hypomyelinating leukodystrophy 2 (Disease Ontology:DOID:0060787); hereditary lymphedema IC (Disease Ontology:DOID:0070208); hereditary spastic paraplegia 44 (Disease Ontology:DOID:0110796); Parkinson's disease (Disease Ontology:DOID:14330); lymphedema (Disease Ontology:DOID:4977)", "pathway": " (mmu:118454); (R-MMU-190861)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;11160382;12805295;12843301;15183511;15676282;16452087;21183079;31219806;31932428;36446400", "class_list": "", "function": "Cx47-deficient mice revealed a vacuolation of nerve fibers at the site of the optic nerve where axons are first contacted by oligodendrocytes and myelination starts; Cx32/Cx47-double-deficient mice developed action tremor and died ca 51 d after birth, [RefSeq, PubMed]; Lack of embryonic homozygous or adult heterozygous lymphatic phenotypes for a Sos1 mutation and lack of lymphatic embryonic phenotypes for a homozygous Cx47 mutation in mice., [RefSeq, PubMed]; Mice lacking either Cx47 or Cx32 are viable but mice lacking both connexins die by postnatal week 6 from CNS myelin sheath abnormalities, vacuolation, enlarged periaxonal collars, oligodendrocyte cell death, and axonal loss, [RefSeq, PubMed]; Oligodendroglia-specific Cx47 ablation induces severe inflammation upon autoimmune demyelination., [RefSeq, PubMed]; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a role in myelination in central and peripheral nervous systems., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6TLV2;Q8BQS2;Q9EPM1", "ec_number_list": [], "go_molecular_function": "GO:1903763 gap junction channel activity involved in cell communication by electrical coupling;GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043025 neuronal cell body;GO:0043204 perikaryon;GO:0043209 myelin sheath;GO:0005921 gap junction", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0010628 positive regulation of gene expression;GO:0009636 response to toxic substance;GO:0001932 regulation of protein phosphorylation;GO:2000134 negative regulation of G1/S transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8BQU6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99J39-1", "uniprot_id": [ { "id": "DCMC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99J39", "type": "external" } ], "mass": 54736.0, "length": 492, "protein_name": "Malonyl-CoA decarboxylase, mitochondrial", "gene_name": "Mlycd", "organism": "Mouse", "refseq_name": "malonyl-CoA decarboxylase, mitochondrial isoform 1 precursor", "refseq_ac": [ { "id": "NP_064350", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064350", "type": "external" } ], "gene_names_uniprotkb": "Mlycd", "gene_names_refseq": "Mcd; Mlycd", "protein_names_uniprotkb": "Malonyl-CoA decarboxylase, mitochondrial; 4.1.1.9; MCD", "protein_names_refseq": "malonyl-CoA decarboxylase, mitochondrial isoform 1 precursor; malonyl-CoA decarboxylase, mitochondrial", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208)", "pathway": " (mmu:56690); (R-MMU-390247); (R-MMU-9033241)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "17030679;19478144;20702857;23576753;23746352;23806337;27207536;37507081", "class_list": "", "function": "Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced. In peroxisomes it may be involved in degrading intraperoxisomal malonyl-CoA, which is generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids. Plays a role in the metabolic balance between glucose and lipid oxidation in muscle independent of alterations in insulin signaling. Plays a role in controlling the extent of ischemic injury by promoting glucose oxidation., [UniProtKB, PubMed, PubMed]; Decreased fat oxidation in MCD(-/-) mice resulted in the accumulation of lipid intermediates in peripheral tissues, but this was not associated with a worsening of age-associated insulin resistance and, conversely, improved longevity., [RefSeq, PubMed]; In vivo and ex vivo cardiac function is similar in wild-type and mcd-deficient mice; however, deletion of MCD markedly increases glucose oxidation and improves functional recovery of the heart after ischemia., [RefSeq, PubMed]; Mcd deficiency is not detrimental to the heart in obesity in mice. Erratum:[Diabetes. 2009 Oct;58(10):2425], [RefSeq, PubMed]; This study of fatty acid oxidation and malonyl-CoA decarboxylase identifies a critical role for metabolism in both the normal pulmonary circulation (hypoxic pulmonary vasoconstriction) and pulmonary hypertension, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7TNL6", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.1.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4", "type": "external" }, { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": 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