[ { "uniprot_canonical_ac": "Q8BMJ7-1", "uniprot_id": [ { "id": "CGRF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BMJ7", "type": "external" } ], "mass": 37899.0, "length": 332, "protein_name": "Cell growth regulator with RING finger domain protein 1", "gene_name": "Cgrrf1", "organism": "Mouse", "refseq_name": "cell growth regulator with RING finger domain protein 1 isoform 1", "refseq_ac": [ { "id": "NP_081108", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081108", "type": "external" } ], "gene_names_uniprotkb": "Cgrrf1; Cgr19", "gene_names_refseq": "1110038G02Rik; 1810009H17Rik; CGR19; Cgrrf1", "protein_names_uniprotkb": "Cell growth regulator with RING finger domain protein 1; Cell growth regulatory gene 19 protein", "protein_names_refseq": "cell growth regulator with RING finger domain protein 1 isoform 1; cell growth regulator with RING finger domain protein 1; cell growth regulatory gene 19 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:68755)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;21750661;25605945", "class_list": "", "function": "Able to inhibit growth in several cell lines., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9606, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U3F1;Q8CI24", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0030308 negative regulation of cell growth;GO:0051726 regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BMJ7-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O89051-1", "uniprot_id": [ { "id": "ITM2B_MOUSE", "url": "https://www.uniprot.org/uniprot/O89051", "type": "external" } ], "mass": 30260.0, "length": 266, "protein_name": "Integral membrane protein 2B", "gene_name": "Itm2b", "organism": "Mouse", "refseq_name": "integral membrane protein 2B precursor", "refseq_ac": [ { "id": "NP_032436", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032436", "type": "external" } ], "gene_names_uniprotkb": "Itm2b", "gene_names_refseq": "Bri2; Bricd2b; Bri; D14Sel6; E25BMM; Itm2b; imBRI2", "protein_names_uniprotkb": "Integral membrane protein 2B; ABri23; Bri; C-terminal peptide; Immature BRI2; Mature BRI2; P23 peptide; Protein E25B; Transmembrane protein BRI; imBRI2; mBRI2", "protein_names_refseq": "immature BRI2; integral membrane protein 2B (E25B protein); integral membrane protein 2B precursor; transmembrane protein BRI", "tax_id": 10090, "disease": "ITM2B-related cerebral amyloid angiopathy 1 (Disease Ontology:DOID:0070029); ITM2B-related cerebral amyloid angiopathy 2 (Disease Ontology:DOID:0070030); cerebral amyloid angiopathy (Disease Ontology:DOID:9246)", "pathway": " (mmu:16432)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;10679242;12082633;12442332;16075062;20945367;21750661;21913724;25605945;26495903;28011936;28935714;30899004;32152506;34428180;35984892;36273719;37828378;38347225;9795190", "class_list": "", "function": "Bri23 peptide prevents aggregation of APP amyloid-beta protein 42 into toxic oligomers., [UniProtKB, UniProtKB, UniProtKB]; Functional BRI2-TREM2 interactions in microglia: implications for Alzheimer's and related dementias., [RefSeq, PubMed]; ITM2B(S) induces apoptosis via a caspase-dependent mitochondrial pathway., [RefSeq, PubMed]; Mature BRI2 (mBRI2) functions as a modulator of the amyloid-beta A4 precursor protein (APP) processing leading to a strong reduction in the secretion of secretase-processed amyloid-beta protein 40 and amyloid-beta protein 42., [UniProtKB, UniProtKB, UniProtKB]; Plays a regulatory role in the processing of the amyloid-beta A4 precursor protein (APP) and acts as an inhibitor of the amyloid-beta peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; S100A9 amyloid growth and S100A9 fibril-induced impairment of gamma oscillations in area CA3 of mouse hippocampus ex vivo is prevented by Bri2 BRICHOS., [RefSeq, PubMed]; The shor form of ITM2B induces apoptosis in IL-2-stimulated cells. The long form can't induce it. ITM2B(s) interacts with Bcl-2, but not with Bad. Mutation of the L and D residues in the BH3 domain abolished the ability of ITM2B(s) to promote apoptosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 3, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q545S7", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0001540 amyloid-beta binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0042985 negative regulation of amyloid precursor protein biosynthetic process;GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "O89051-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61048-1", "uniprot_id": [ { "id": "WBP4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61048", "type": "external" } ], "mass": 42137.0, "length": 376, "protein_name": "WW domain-binding protein 4", "gene_name": "Wbp4", "organism": "Mouse", "refseq_name": "WW domain-binding protein 4", "refseq_ac": [ { "id": "NP_061235", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061235", "type": "external" } ], "gene_names_uniprotkb": "Wbp4; Fbp21; Fnbp21", "gene_names_refseq": "FBP21; Wbp4", "protein_names_uniprotkb": "WW domain-binding protein 4; Formin-binding protein 21; WBP-4; WW domain-containing-binding protein 4", "protein_names_refseq": "WBP-4; WW domain-binding protein 4; WW domain-containing-binding protein 4; formin binding protein 21", "tax_id": 10090, "disease": "", "pathway": " (mmu:22380); (R-MMU-72163)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10748127;21750661;31599954;34428180;9724750", "class_list": "", "function": "Involved in pre-mRNA splicing as a component of the spliceosome. May play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TUU8;Q8K1Z9;Q9CS45", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0070064 proline-rich region binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0071011 precatalytic spliceosome", "go_biological_process": "GO:0008380 RNA splicing;GO:0000398 mRNA splicing, via spliceosome;GO:0045292 mRNA cis splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q61048-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EP79-1", "uniprot_id": [ { "id": "V1R52_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EP79", "type": "external" } ], "mass": 35050.0, "length": 309, "protein_name": "Vomeronasal type-1 receptor 52", "gene_name": "Vmn1r52", "organism": "Mouse", "refseq_name": "vomeronasal type-1 receptor 52", "refseq_ac": [ { "id": "NP_444452", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444452", "type": "external" } ], "gene_names_uniprotkb": "Vmn1r52; V1ra7", "gene_names_refseq": "V1ra7; VN3; Vmn1r52", "protein_names_uniprotkb": "Vomeronasal type-1 receptor 52; Pheromone receptor VN3; Vomeronasal receptor 3; Vomeronasal type-1 receptor A7", "protein_names_refseq": "pheromone receptor VN3; vomernasal 1 receptor Vmn1r52; vomeronasal 1 receptor, A7; vomeronasal receptor 3; vomeronasal type-1 receptor 52; vomeronasal type-1 receptor A7", "tax_id": 10090, "disease": "", "pathway": " (mmu:113849)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11116090;11752409;12214233;21750661", "class_list": "", "function": "Putative pheromone receptor implicated in the regulation of social and reproductive behavior., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005550 pheromone binding;GO:0016503 pheromone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9EP79-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61704-1", "uniprot_id": [ { "id": "ITIH3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61704", "type": "external" } ], "mass": 99358.0, "length": 889, "protein_name": "Inter-alpha-trypsin inhibitor heavy chain H3", "gene_name": "Itih3", "organism": "Mouse", "refseq_name": "inter-alpha-trypsin inhibitor heavy chain H3 isoform 1 preproprotein", "refseq_ac": [ { "id": "NP_032433", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032433", "type": "external" } ], "gene_names_uniprotkb": "Itih3", "gene_names_refseq": "ITI-HC3; Intin3; Itih-3; Itih3", "protein_names_uniprotkb": "Inter-alpha-trypsin inhibitor heavy chain H3; ITI heavy chain H3; ITI-HC3; Inter-alpha-inhibitor heavy chain 3", "protein_names_refseq": "ITI heavy chain H3; inter-alpha-inhibitor H3 chain; inter-alpha-inhibitor heavy chain 3; inter-alpha-trypsin inhibitor heavy chain H3 isoform 1 preproprotein; inter-alpha-trypsin inhibitor heavy chain H3", "tax_id": 10090, "disease": "", "pathway": " (mmu:16426); (R-MMU-114608)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;16944957;20571061;21750661;23386199;26495903;26740625;30084848;33300544;34428180;37828378;38641154;7534067", "class_list": "", "function": "MSC-derived exosomes deliver ZBTB4 to mediate transcriptional repression of ITIH3 in astrocytes in spinal cord injury., [RefSeq, PubMed]; May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes., [UniProtKB, UniProtKB, UniProtKB]; This gene encodes one of the heavy subunits of inter alpha trypsin inhibitor that functions as a protease inhibitor circulating in the plasma. The encoded protein undergoes proteolytic processing to generate a mature glycoprotein that is linked to the other subunits via an ester bond between the C-terminal aspartic acid residue and the N-acetyl galactosamine residue of chondroitin sulfate. This gene is located in a cluster of related inter alpha trypsin inhibitor genes on chromosome 14. [provided by RefSeq, Oct 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "E9QME9;Q91WG9", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix", "go_biological_process": "GO:0030212 hyaluronan metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q61704-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6X935-1", "uniprot_id": [ { "id": "ITIH4_MOUSE", "url": "https://www.uniprot.org/uniprot/A6X935", "type": "external" } ], "mass": 104659.0, "length": 942, "protein_name": "Inter alpha-trypsin inhibitor, heavy chain 4", "gene_name": "Itih4", "organism": "Mouse", "refseq_name": "inter alpha-trypsin inhibitor, heavy chain 4 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001152771", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152771", "type": "external" } ], "gene_names_uniprotkb": "Itih4", "gene_names_refseq": "ITI-HC4; Itih-4; Itih4; PK-120", "protein_names_uniprotkb": "Inter alpha-trypsin inhibitor, heavy chain 4; ITI heavy chain H4; ITI-HC4; Inter-alpha-inhibitor heavy chain 4", "protein_names_refseq": "ITI heavy chain H4; inter alpha-trypsin inhibitor, heavy chain 4 isoform 2 precursor; inter-alpha-inhibitor heavy chain 4", "tax_id": 10090, "disease": "pulmonary tuberculosis (Disease Ontology:DOID:2957); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); liver cirrhosis (Disease Ontology:DOID:5082); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); intermediate coronary syndrome (Disease Ontology:DOID:8805); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:16427); (R-MMU-114608)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;11803570;16271702;16944957;17330941;20571061;21750661;26495903;28011936;30958362;33725478;34428180;35820727;37507081;38190323;38289873;39627609;9602042", "class_list": "", "function": "Acute Anti-Inflammatory Markers ITIH4 and AHSG in Mice Brain of a Novel Alzheimer's Disease Model., [RefSeq, PubMed]; Role in liver development and regeneration, [RefSeq, PubMed]; Role of inter-alpha-trypsin inhibitor heavy chain 4 and its citrullinated form in experimental arthritis murine models., [RefSeq, PubMed]; This gene encodes a member of the inter-alpha trypsin inhibitor (IaI) family of plasma serine protease inhibitors with diverse functions as anti-apoptotic and matrix stabilizing molecules during development. This gene is predominantly expressed in the liver and the encoded protein was found to be a plasma kallikrein-sensitive glycoprotein. This gene is located in a cluster of related inter alpha trypsin inhibitor genes on chromosome 14. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015]., [RefSeq]; Translatome profiling reveals Itih4 as a novel smooth muscle cell-specific gene in atherosclerosis., [RefSeq, PubMed]; Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 7, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "O54882;Q505P8;Q8C7G9;Q8C7K5;Q91W60;Q9DBK8", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0031012 extracellular matrix;GO:0005576 extracellular region", "go_biological_process": "GO:0006953 acute-phase response;GO:0034097 response to cytokine;GO:0030212 hyaluronan metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "A6X935-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000001000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91YN0-1", "uniprot_id": [ { "id": "FERY3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91YN0", "type": "external" } ], "mass": 63644.0, "length": 552, "protein_name": "FERRY endosomal RAB5 effector complex subunit 3", "gene_name": "D6Wsu163e; Ferry3", "organism": "Mouse", "refseq_name": "FERRY endosomal RAB5 effector complex subunit 3 isoform a", "refseq_ac": [ { "id": "NP_613060", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_613060", "type": "external" } ], "gene_names_uniprotkb": "D6Wsu163e; Ferry3; D6Wsu163e", "gene_names_refseq": "C12orf4; D6Wsu163e; Ferry3", "protein_names_uniprotkb": "FERRY endosomal RAB5 effector complex subunit 3", "protein_names_refseq": "FERRY endosomal RAB5 effector complex subunit 3 isoform a; protein C12orf4 homolog", "tax_id": 10090, "disease": "autosomal recessive intellectual developmental disorder 66 (Disease Ontology:DOID:0081227)", "pathway": " (mmu:28040)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;31219806;34428180;36210013", "class_list": "", "function": "Component of the FERRY complex (Five-subunit Endosomal Rab5 and RNA/ribosome intermediary). The FERRY complex directly interacts with mRNAs and RAB5A, and functions as a RAB5A effector involved in the localization and the distribution of specific mRNAs most likely by mediating their endosomal transport. The complex recruits mRNAs and ribosomes to early endosomes through direct mRNA-interaction (By similarity). Plays a role in mast cell degranulation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9652, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UVK4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0032991 protein-containing complex", "go_biological_process": "GO:0043304 regulation of mast cell degranulation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q91YN0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2H6-1", "uniprot_id": [ { "id": "CLC4D_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z2H6", "type": "external" } ], "mass": 25619.0, "length": 219, "protein_name": "C-type lectin domain family 4 member D", "gene_name": "Clec4d", "organism": "Mouse", "refseq_name": "C-type lectin domain family 4 member D isoform 2", "refseq_ac": [ { "id": "NP_001156633", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156633", "type": "external" } ], "gene_names_uniprotkb": "Clec4d; Clecsf8; Mcl", "gene_names_refseq": "Clec4d; Clecsf8; Mpcl; mcl", "protein_names_uniprotkb": "C-type lectin domain family 4 member D; C-type lectin superfamily member 8; DC-associated C-type lectin 3; Dectin-3; Dendritic cell-associated C-type lectin 3; Macrophage-restricted C-type lectin", "protein_names_refseq": "C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 8; C-type lectin domain family 4 member D isoform 2; C-type lectin, superfamily member 8; DC-associated C-type lectin 3; dectin-3; dendritic cell-associated C-type lectin 3; macrophage C-type lectin; macrophage-restricted C-type lectin", "tax_id": 10090, "disease": "", "pathway": " (mmu:17474); (R-MMU-5621480); (R-MMU-6798695)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "11841491;21750661;23602766;23911656;35920835;37799716;9660840", "class_list": "glycogene", "function": "C-type lectin Mincle-dependent and -independent activation of invariant NKT cells by exposure to Helicobacter pylori alpha-cholesteryl glucosides., [RefSeq, PubMed]; C-type lectin receptor expression is a hallmark of neutrophils infiltrating the skin in epidermolysis bullosa acquisita. Publication Status: Online-Only, [RefSeq, PubMed]; Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: recognizes damage-associated molecular patterns (DAMPs) of pathogen-associated molecular patterns (PAMPs) of bacteria and fungi. The PAMPs include alpha-mannans on C.albicans hypheas and mycobacterial trehalose 6,6'-dimycolate (TDM) (PubMed:23602766, PubMed:23911656). Interacts with signaling adapter Fc receptor gamma chain/FCER1G, likely via CLEC4E, to form a functional complex in myeloid cells (By similarity). Binding of mycobacterial TDM or C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (PubMed:23602766, PubMed:23911656). The heterodimer formed with CLEC6A is active against fungal infection (By similarity). Functions as an endocytic receptor (By similarity). May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T-cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; The genomic organization of the MCL gene and the sequence of the promoter region were determined, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 19, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8C212", "ec_number_list": [], "go_molecular_function": "GO:0034987 immunoglobulin receptor binding;GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0005537 D-mannose binding;GO:0038187 pattern recognition receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0002292 T cell differentiation involved in immune response;GO:0038094 Fc-gamma receptor signaling pathway;GO:0045087 innate immune response;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9Z2H6-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R014-1", "uniprot_id": [ { "id": "CATJ_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R014", "type": "external" } ], "mass": 37276.0, "length": 334, "protein_name": "Cathepsin J", "gene_name": "Ctsj", "organism": "Mouse", "refseq_name": "cathepsin J isoform 2 precursor", "refseq_ac": [ { "id": "NP_036137", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036137", "type": "external" } ], "gene_names_uniprotkb": "Ctsj; Ctsp", "gene_names_refseq": "CATP; CatRLP; Ctsj; Ctsp", "protein_names_uniprotkb": "Cathepsin J; 3.4.22.-; Cathepsin L-related protein; Cathepsin P; Catlrp-p", "protein_names_refseq": "Cat P; cathepsin J isoform 2 precursor; cathepsin L-related protein; cathepsin P; catlrp-p; gene/Cathepsin L-related protein", "tax_id": 10090, "disease": "COVID-19 (Disease Ontology:DOID:0080600); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); alcohol use disorder (Disease Ontology:DOID:1574); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:26898)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10526153;11829493;15680921;21750661;40885482", "class_list": "", "function": "These results show that cathepsin P, in contrast to other mammalian cathepsins, has a restricted catalytic specificity., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q564D9;Q91XK6;Q9WV51", "ec_number_list": [], "go_molecular_function": "GO:0005518 collagen binding;GO:0042393 histone binding;GO:0043394 proteoglycan binding;GO:0001968 fibronectin binding;GO:0004197 cysteine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0005764 lysosome", "go_biological_process": "GO:0006508 proteolysis;GO:0046718 symbiont entry into host cell;GO:0016540 protein autoprocessing;GO:0030574 collagen catabolic process;GO:0051603 proteolysis involved in protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9R014-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DAC0-1", "uniprot_id": [ { "id": "CLF2B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DAC0", "type": "external" } ], "mass": 24366.0, "length": 210, "protein_name": "CKLF-like MARVEL transmembrane domain-containing protein 2B", "gene_name": "Cmtm2b", "organism": "Mouse", "refseq_name": "CKLF-like MARVEL transmembrane domain-containing protein 2B", "refseq_ac": [ { "id": "NP_082800", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082800", "type": "external" } ], "gene_names_uniprotkb": "Cmtm2b; Cklfsf2b", "gene_names_refseq": "1700013O04Rik; Cklfsf22; Cklfsf2b; Cmtm2b", "protein_names_uniprotkb": "CKLF-like MARVEL transmembrane domain-containing protein 2B; Chemokine-like factor superfamily member 2B", "protein_names_refseq": "CKLF-like MARVEL transmembrane domain-containing protein 2B; chemokine-like factor super family 2B; chemokine-like factor superfamily member 2B; chemokine-like factor superfamily protein 2-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:75502)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16343975;21750661;30209135;30321752", "class_list": "", "function": "Co-expression of sperm membrane proteins CMTM2A and CMTM2B is required for male fertility and affects the localization of the sperm membrane protein ADAM3 in regulating sperm fertilizing ability. Publication Status: Online-Only, [RefSeq, PubMed]; Data show that mouse Cklfsf2a and Cklfsf2b are two homologues of human CKLFSF2., [RefSeq, PubMed]; These findings suggest that CKLFSF2B might be involved in the development and function of Leydig cells and regulate testicular testosterone production by fine-tuning the expression of steroidogenic genes, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane", "go_biological_process": "GO:0006935 chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9DAC0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R1I1-1", "uniprot_id": [ { "id": "CHST4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R1I1", "type": "external" } ], "mass": 44636.0, "length": 388, "protein_name": "Carbohydrate sulfotransferase 4", "gene_name": "Chst4", "organism": "Mouse", "refseq_name": "carbohydrate sulfotransferase 4", "refseq_ac": [ { "id": "NP_036128", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036128", "type": "external" } ], "gene_names_uniprotkb": "Chst4; Gst3", "gene_names_refseq": "Chst4; GST-3; Gn6st-2; HEC-GlcNAc6ST", "protein_names_uniprotkb": "Carbohydrate sulfotransferase 4; 2.8.2.-; GST-3; Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 3; GlcNAc6ST-2; Gn6st-2; HEC-GlcNAc6ST; High endothelial cells N-acetylglucosamine 6-O-sulfotransferase; L-selectin ligand sulfotransferase; LSST; N-acetylglucosamine 6-O-sulfotransferase 2", "protein_names_refseq": "L-selectin ligand sulfotransferase; LSST; N-acetylglucosamine 6-O-sulfotransferase 2; carbohydrate (chondroitin 6/keratan) sulfotransferase 4; carbohydrate sulfotransferase 4; galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 3; glcNAc6ST-2; high endothelial cell GlcNAC-6-sulphotransferase; high endothelial cells N-acetylglucosamine 6-O-sulfotransferase", "tax_id": 10090, "disease": "macular corneal dystrophy (Disease Ontology:DOID:2565)", "pathway": " (mmu:26887); (R-MMU-913709)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10330415;10435581;11520459;14593101;14597732;15111310;15319280;16227985;16227986;21750661;30779550", "class_list": "glycogene", "function": "Sulfotransferase involved in SELL/L-selectin ligand biosynthesis pathway. Catalyzes the transfer of the sulfate group from 3'-phospho-5'-adenylyl sulfate (PAPS) onto the hydroxyl group at C-6 position of the non-reducing N-acetylglucosamine (GlcNAc) residue within O-linked mucin-type glycans (PubMed:10435581, PubMed:14597732, PubMed:15111310, PubMed:15319280, PubMed:16227985, PubMed:16227986). Contributes to generate sialyl 6-sulfo Lewis X determinant (also known as MECA-79 epitope) for SELL recognition, a prerequisite for continuous lymphocyte homing into peripheral lymph nodes and antigen immune surveillance. Transfers the sulfate group primarily on core 2 GlcNAcbeta1-6(Galbeta1-3)GalNAcalphaSer/Thr and extended core 1 GlcNAcbeta1-3Galbeta1-3GalNAcalphaSer/Thr based O-linked glycans on CD34 and GLYCAM1 peripheral node addressins (PNAds) expressed on the lumenal side of high endothelial venules (HEVs) (PubMed:10435581, PubMed:14593101, PubMed:15111310, PubMed:15319280, PubMed:16227985, PubMed:16227986). The recognition of PNAds by SELL initiates a multistep process comprising tethering and rolling of blood lymphocytes on HEVs against the blood flow, followed by chemokine signaling, integrin-mediated lymphocyte adhesion onto endothelial cells and lymphocyte transendothelial migration. Modulates rolling velocity and differential T and B lymphocyte recruitment into peripheral lymph nodes, with a major role in B lymphocyte homing (PubMed:10435581, PubMed:14597732, PubMed:15319280, PubMed:16227985, PubMed:16227986). Might be redundant in sulfation of MADCAM1 and lymphocyte trafficking to mesenteric lymph nodes (PubMed:10435581, PubMed:11520459, PubMed:16227986). Can also sulfonate core 3 GlcNAcbeta1-3GalNAc-R based glycans as well as GlcNAcbeta1-3Galbeta1-Glc, GlcNAcbeta1-6ManOMe and GlcNAcbeta1-2Man oligosaccharides, which might be ectopically expressed during tumorigenesis (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 19, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9WUE5", "ec_number_list": [ { "id": "2.8.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.-", "type": "external" } ], "go_molecular_function": "GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0006044 N-acetylglucosamine metabolic process;GO:0006477 protein sulfation;GO:1903238 positive regulation of leukocyte tethering or rolling;GO:0006954 inflammatory response;GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9R1I1-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000011000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91ZF2-1", "uniprot_id": [ { "id": "CAT7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91ZF2", "type": "external" } ], "mass": 37725.0, "length": 331, "protein_name": "Cathepsin 7", "gene_name": "Cts7", "organism": "Mouse", "refseq_name": "cathepsin 7 preproprotein", "refseq_ac": [ { "id": "NP_062412", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062412", "type": "external" } ], "gene_names_uniprotkb": "Cts7; Cts1; Epcs24", "gene_names_refseq": "CTS1; Cts7; Epcs24; Epcs71", "protein_names_uniprotkb": "Cathepsin 7; 3.4.22.-; Cathepsin 1", "protein_names_refseq": "cathepsin 1; cathepsin 7 preproprotein", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:56092)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10885754;11829493;18776147;21750661;23541586", "class_list": "", "function": "Disruption of IRE1alpha and XBP1 drastically attenuated the expression of Cts7 and Cts8, which are essential cathepsins for placenta formation., [RefSeq, PubMed]; Involved in trophoblast cell proliferation and differentiation probably by affecting mitotic cell cycle progression. Proteolytic activity and nuclear localization are essential for its role in cell cycle progression., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9JI84", "ec_number_list": [], "go_molecular_function": "GO:0008233 peptidase activity;GO:0004197 cysteine-type endopeptidase activity;GO:0008234 cysteine-type peptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005768 endosome;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006508 proteolysis;GO:0051301 cell division;GO:0045930 negative regulation of mitotic cell cycle;GO:0051603 proteolysis involved in protein catabolic process;GO:0060707 trophoblast giant cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q91ZF2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C1F4-1", "uniprot_id": [ { "id": "CGAT2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C1F4", "type": "external" } ], "mass": 62530.0, "length": 542, "protein_name": "Chondroitin sulfate N-acetylgalactosaminyltransferase 2", "gene_name": "Csgalnact2", "organism": "Mouse", "refseq_name": "chondroitin sulfate N-acetylgalactosaminyltransferase 2", "refseq_ac": [ { "id": "NP_084441", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084441", "type": "external" } ], "gene_names_uniprotkb": "Csgalnact2; Chgn2; Galnact2", "gene_names_refseq": "4632415D10Rik; Csgalnact2; Galnact2", "protein_names_uniprotkb": "Chondroitin sulfate N-acetylgalactosaminyltransferase 2; 2.4.1.174; Beta4GalNAcT-2; Chondroitin beta-1,4-N-acetylgalactosaminyltransferase 2; GalNAcT-2", "protein_names_refseq": "beta4GalNAcT-2; chondroitin beta-1,4-N-acetylgalactosaminyltransferase 2; chondroitin sulfate GalNAcT-2; chondroitin sulfate N-acetylgalactosaminyltransferase 2; galNAcT-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:78752); (R-MMU-2022870)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;30579596;33504177", "class_list": "glycogene;glycosyltransferase", "function": "Chondroitin Sulfate N-acetylgalactosaminyltransferase-2 Impacts Foam Cell Formation and Atherosclerosis by Altering Macrophage Glycosaminoglycan Chain., [RefSeq, PubMed]; Chondroitin sulfate N-acetylgalactosaminyltransferase 2 is functionally involved in the progression of atherosclerosis both in its early and advanced stages., [RefSeq, PubMed]; Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 21, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6PAP6;Q8R5A2;Q9D2M1", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.174", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.174", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008376 acetylgalactosaminyltransferase activity;GO:0047237 glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity;GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0050650 chondroitin sulfate proteoglycan biosynthetic process;GO:0050651 dermatan sulfate proteoglycan biosynthetic process;GO:0030166 proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8C1F4-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BQ86-1", "uniprot_id": [ { "id": "CHST8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BQ86", "type": "external" } ], "mass": 48282.0, "length": 417, "protein_name": "Carbohydrate sulfotransferase 8", "gene_name": "Chst8", "organism": "Mouse", "refseq_name": "carbohydrate sulfotransferase 8", "refseq_ac": [ { "id": "NP_780349", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780349", "type": "external" } ], "gene_names_uniprotkb": "Chst8", "gene_names_refseq": "1500011J21Rik; Chst8", "protein_names_uniprotkb": "Carbohydrate sulfotransferase 8; 2.8.2.-; GalNAc-4-O-sulfotransferase 1; GalNAc-4-ST1; GalNAc4ST-1; N-acetylgalactosamine-4-O-sulfotransferase 1", "protein_names_refseq": "GalNAc4ST-1; N-acetylgalactosamine-4-O-sulfotransferase 1; carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8; carbohydrate sulfotransferase 8; galNAc-4-O-sulfotransferase 1; galNAc-4-ST1", "tax_id": 10090, "disease": "", "pathway": " (mmu:68947); (R-MMU-975578)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;12944377;16079414;18431515;21750661;30899004", "class_list": "glycan-modifying enzyme;glycogene;glycosyltransferase", "function": "Analysis of enzymatic properties and expression of GalNAc-4-sulfotransferase-1 and GalNAc-4-sulfotransferase-2, [RefSeq, PubMed]; Catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans (By similarity). Transfers sulfate to the 4-position of GalNAc in the context of GalNAcbeta1->4GlcNAcbeta1->R attached to both N-linked and core 2 branched O-linked oligosaccharides (By similarity). Required for biosynthesis of glycoprotein hormones such as LH, by mediating sulfation of their carbohydrate structure (PubMed:18431515). Not active toward chondroitin (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 25, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 5, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q76EC6;Q80XD4", "ec_number_list": [ { "id": "2.8.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.-", "type": "external" } ], "go_molecular_function": "GO:0008146 sulfotransferase activity;GO:0001537 dermatan 4-sulfotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0016051 carbohydrate biosynthetic process;GO:0016486 peptide hormone processing;GO:0042446 hormone biosynthetic process;GO:0006790 sulfur compound metabolic process;GO:0030166 proteoglycan biosynthetic process", "synthesized_glycan_count": 139, "hit_score": 1.6, "record_id": "Q8BQ86-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000011000.101.11010", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R1U2-1", "uniprot_id": [ { "id": "CGRE1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R1U2", "type": "external" } ], "mass": 30847.0, "length": 281, "protein_name": "Cell growth regulator with EF hand domain protein 1", "gene_name": "Cgref1", "organism": "Mouse", "refseq_name": "cell growth regulator with EF hand domain protein 1 precursor", "refseq_ac": [ { "id": "NP_001153621", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153621", "type": "external" } ], "gene_names_uniprotkb": "Cgref1; Cgr11", "gene_names_refseq": "1110004G24Rik; Cgr11; Cgref1", "protein_names_uniprotkb": "Cell growth regulator with EF hand domain protein 1; Cell growth regulatory gene 11 protein; Hydrophobestin", "protein_names_refseq": "cell growth regulator with EF hand domain protein 1 precursor; cell growth regulator with EF hand domain protein 1; cell growth regulatory gene 11 protein; cell growth regulatory with EF-hand domain; hydrophobestin", "tax_id": 10090, "disease": "", "pathway": " (mmu:68567)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21183079;21750661", "class_list": "", "function": "Mediates cell-cell adhesion in a calcium-dependent manner. Able to inhibit growth in several cell lines (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D1K1", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0007155 cell adhesion;GO:0030308 negative regulation of cell growth;GO:0051726 regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8R1U2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BM92-1", "uniprot_id": [ { "id": "CADH7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BM92", "type": "external" } ], "mass": 87202.0, "length": 785, "protein_name": "Cadherin-7", "gene_name": "Cdh7", "organism": "Mouse", "refseq_name": "cadherin-7 isoform 1 preproprotein", "refseq_ac": [ { "id": "NP_001303672", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001303672", "type": "external" } ], "gene_names_uniprotkb": "Cdh7", "gene_names_refseq": "9330156F07Rik; CDH7L1; Cdh7", "protein_names_uniprotkb": "Cadherin-7", "protein_names_refseq": "cadherin-7 isoform 1 preproprotein; cadherin-7", "tax_id": 10090, "disease": "", "pathway": " (mmu:241201); (R-MMU-418990)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;15273735;21750661;34004180", "class_list": "", "function": "Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity)., [UniProtKB]; Chromatin remodeler CHD7 is critical for cochlear morphogenesis and neurosensory patterning., [RefSeq, PubMed]; This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene is located adjacent to a related cadherin gene on chromosome 1. [provided by RefSeq, Oct 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UVE2;Q67G09", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005912 adherens junction;GO:0016342 catenin complex;GO:0016020 membrane", "go_biological_process": "GO:0016477 cell migration;GO:0000902 cell morphogenesis;GO:0007043 cell-cell junction assembly;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0034332 adherens junction organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BM92-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BHH8-1", "uniprot_id": [ { "id": "CLRN3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BHH8", "type": "external" } ], "mass": 25350.0, "length": 226, "protein_name": "Clarin-3", "gene_name": "Clrn3", "organism": "Mouse", "refseq_name": "clarin-3", "refseq_ac": [ { "id": "NP_848784", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848784", "type": "external" } ], "gene_names_uniprotkb": "Clrn3; Tmem12", "gene_names_refseq": "Clrn3; Tmem12", "protein_names_uniprotkb": "Clarin-3; Transmembrane protein 12", "protein_names_refseq": "clarin-3; transmembrane protein 12", "tax_id": 10090, "disease": "", "pathway": " (mmu:212070)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0007605 sensory perception of sound", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8BHH8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BHN9-1", "uniprot_id": [ { "id": "CLBA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BHN9", "type": "external" } ], "mass": 34683.0, "length": 321, "protein_name": "Uncharacterized protein CLBA1", "gene_name": "Clba1", "organism": "Mouse", "refseq_name": "uncharacterized protein CLBA1", "refseq_ac": [ { "id": "NP_663425", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663425", "type": "external" } ], "gene_names_uniprotkb": "Clba1", "gene_names_refseq": "C130001I08Rik; Clba1; Flj20080", "protein_names_uniprotkb": "Uncharacterized protein CLBA1; Clathrin-binding box of aftiphilin-containing protein 1", "protein_names_refseq": "clathrin-binding box of aftiphilin-containing protein 1; uncharacterized protein C14orf79 homolog; uncharacterized protein CLBA1", "tax_id": 10090, "disease": "", "pathway": " (mmu:217887)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17971504;31219806", "class_list": "", "function": "BC022687 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R1Z8", "ec_number_list": [], "go_molecular_function": "GO:0030276 clathrin binding", "go_cellular_component": "GO:0032588 trans-Golgi network membrane;GO:0030121 AP-1 adaptor complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BHN9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BIF0-1", "uniprot_id": [ { "id": "C99L2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BIF0", "type": "external" } ], "mass": 25463.0, "length": 237, "protein_name": "CD99 antigen-like protein 2", "gene_name": "Cd99l2", "organism": "Mouse", "refseq_name": "CD99 antigen-like protein 2 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001186278", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186278", "type": "external" } ], "gene_names_uniprotkb": "Cd99l2; Mic2l1", "gene_names_refseq": "Cd99l2; Mic2l1; Xap89", "protein_names_uniprotkb": "CD99 antigen-like protein 2; MIC2-like protein 1", "protein_names_refseq": "CD99 antigen-like protein 2 isoform 1 precursor; CD99 antigen-like protein 2; MIC2 (monoclonal Imperial Cancer Research Fund 2)-like 1; MIC2 like-1; MIC2-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:171486)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "12706889;17344467;18163232;20479283;21750661;23293350;23338758;26192747;26321243;29791026;35820727", "class_list": "", "function": "CD99L2 is an essential endothelial Ag for leukocyte extravasation, which does not require homophilic interactions with CD99L2 on leukocytes., [RefSeq, PubMed]; Conditional Tie-2-Cre driven gene inactivation of CD99L2 inhibits leukocyte entry into the CNS during active MOG35-55 -induced experimental autoimmune encephalomyelitis and alleviates severity of the disease. CD99L2 participates in the development of EAE by supporting diapedesis of leukocytes through the endothelial basement membrane of blood vessels of the BBB in the CNS., [RefSeq, PubMed]; Expressed on mouse leukocytes and endothelial cells and is involved in transendothelial migration of neutrophils in vitro and in the recruitment of neutrophils into inflamed peritoneum, [RefSeq, PubMed]; Mice lacking CD99L2 had a defective inflammatory response in the thioglycollate peritonitis model, [RefSeq, PubMed]; Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Homophilic adhesion molecule, but these interactions may not be required for cell aggregation., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; The present study provides data for further investigation into the mCD99L2 gene in tumor cells., [RefSeq, PubMed]; Transfection of L cell fibroblasts with CD99L2 imparted to them the ability to adhere to each other in a divalent cation-dependent, homophilic manner. Anti-CD99L2 antibody blocked influx of neutrophils and monocytes into a site of inflammation in vivo., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A2AP77;Q8R447", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0009986 cell surface;GO:0070161 anchoring junction", "go_biological_process": "GO:0034109 homotypic cell-cell adhesion;GO:0007155 cell adhesion;GO:2000391 positive regulation of neutrophil extravasation;GO:0050904 diapedesis;GO:2000409 positive regulation of T cell extravasation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8BIF0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BM88-1", "uniprot_id": [ { "id": "CATO_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BM88", "type": "external" } ], "mass": 34723.0, "length": 312, "protein_name": "Cathepsin O", "gene_name": "Ctso", "organism": "Mouse", "refseq_name": "cathepsin O preproprotein", "refseq_ac": [ { "id": "NP_808330", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808330", "type": "external" } ], "gene_names_uniprotkb": "Ctso", "gene_names_refseq": "A330105D01Rik; Ctso", "protein_names_uniprotkb": "Cathepsin O; 3.4.22.42", "protein_names_refseq": "cathepsin O preproprotein", "tax_id": 10090, "disease": "", "pathway": " (mmu:229445); (R-MMU-2132295)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;26740625", "class_list": "", "function": "Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover., [UniProtKB]; This gene encodes a member of the cathepsin family of cysteine proteases that are involved in the degradation of cellular proteins. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional enzyme. [provided by RefSeq, Jan 2016]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TM69;Q80V35;Q8BKX0", "ec_number_list": [ { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.4.22.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.15", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.4.16.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.5", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "3.4.22.38", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.38", "type": "external" }, { "id": "3.4.23.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.34", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "3.4.22.42", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.42", "type": "external" }, { "id": "3.4.22.41", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.41", "type": "external" } ], "go_molecular_function": "GO:0004197 cysteine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005764 lysosome", "go_biological_process": "GO:0051603 proteolysis involved in protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BM88-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BME9-1", "uniprot_id": [ { "id": "CBLN4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BME9", "type": "external" } ], "mass": 21609.0, "length": 198, "protein_name": "Cerebellin-4", "gene_name": "Cbln4", "organism": "Mouse", "refseq_name": "cerebellin-4 precursor", "refseq_ac": [ { "id": "NP_783439", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783439", "type": "external" } ], "gene_names_uniprotkb": "Cbln4; Cblnl1", "gene_names_refseq": "Cbln4", "protein_names_uniprotkb": "Cerebellin-4; Cerebellin-like glycoprotein 1", "protein_names_refseq": "cerebellin-4 precursor; cerebellin-4; cerebellin-like glycoprotein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:228942)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;12617826;16930405;17030622;17331201;22220752;25534236;29691328;29782851;30287486;30679375;30899004", "class_list": "", "function": "Acts as a synaptic organizer in specific subsets of neurons in the brain (PubMed:29691328). Essential for the formation and maintenance of inhibitory GABAergic synapses (PubMed:25534236). Promotes the development of dendrite-targeting inhibitory GABAergic synapses made by somatostatin-positive interneurons (PubMed:30679375). May contribute to the function of ventral medial habenula region of the brain implicated in the regulation of anxiety-related behaviors (PubMed:30287486). May play a role in CBLN3 export from the endoplasmic reticulum and secretion (PubMed:17030622)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q505H5;Q8BMF0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0045202 synapse", "go_biological_process": "GO:0099558 maintenance of synapse structure;GO:0009306 protein secretion;GO:0099550 trans-synaptic signaling, modulating synaptic transmission;GO:1904862 inhibitory synapse assembly", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q8BME9-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BTC1-1", "uniprot_id": [ { "id": "UQCC6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BTC1", "type": "external" } ], "mass": 7540.0, "length": 67, "protein_name": "Ubiquinol-cytochrome c reductase complex assembly factor 6", "gene_name": "Uqcc6", "organism": "Mouse", "refseq_name": "ubiquinol-cytochrome c reductase complex assembly factor 6", "refseq_ac": [ { "id": "NP_001129039", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129039", "type": "external" } ], "gene_names_uniprotkb": "Uqcc6; 1190007I07Rik; Brawnin; Br", "gene_names_refseq": "1190007I07Rik; Brawnin; Br; Uqcc6", "protein_names_uniprotkb": "Ubiquinol-cytochrome c reductase complex assembly factor 6; Protein BRAWNIN", "protein_names_refseq": "protein BRAWNIN; ubiquinol-cytochrome c reductase complex assembly factor 6; uncharacterized protein C12orf73 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:544717)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;31219806;32161263;35977508", "class_list": "", "function": "Required for the assembly and stability of the mitochondrial ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain (ETC) which drives oxidative phosphorylation (PubMed:32161263, PubMed:35977508). Mediates early complex III biogenesis (PubMed:35977508). Participates in regulating the levels of electron transport chain proteins, and therefore energy supply, in response to changes in energy demand (PubMed:35977508). Also required for cytochrome c oxidase complex (complex IV) assembly (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0033617 mitochondrial respiratory chain complex IV assembly;GO:0034551 mitochondrial respiratory chain complex III assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BTC1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BTG6-1", "uniprot_id": [ { "id": "SPRNG_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BTG6", "type": "external" } ], "mass": 23477.0, "length": 205, "protein_name": "SREBP regulating gene protein", "gene_name": "Spring1", "organism": "Mouse", "refseq_name": "SREBP regulating gene protein", "refseq_ac": [ { "id": "NP_001074705", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074705", "type": "external" } ], "gene_names_uniprotkb": "Spring1; Spring", "gene_names_refseq": "2410131K14Rik; Spring1; Spring", "protein_names_uniprotkb": "SREBP regulating gene protein; SREBF pathway regulator in Golgi 1", "protein_names_refseq": "SREBP regulating gene protein; UPF0454 protein C12orf49 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:76792)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;32111832", "class_list": "", "function": "Positively regulates hepatic SREBP signaling pathway by modulating the proper localization of SCAP (SREBP cleavage-activating protein) to the endoplasmic reticulum, thereby controlling the level of functional SCAP (PubMed:32111832). Plays a crucial role during embryogenesis (PubMed:32111832)., [UniProtKB, PubMed]; Sterol-regulatory element binding proteins (SREBP) regulating gene (SPRING/C12ORF49) is a glycosylated Golgi membrane protein and its ablation reduces SREBP signaling. Spring deletion is embryonic lethal yet silencing of hepatic Spring expression attenuates the SREBP response. Attenuated SREBP signaling in SPRING(KO) cells results from reduced SREBP cleavage-activating protein (SCAP) and its mislocalization to the Golgi. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:2000640 positive regulation of SREBP signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BTG6-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BWY9-1", "uniprot_id": [ { "id": "CIP2A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BWY9", "type": "external" } ], "mass": 102043.0, "length": 907, "protein_name": "Protein CIP2A", "gene_name": "Cip2a", "organism": "Mouse", "refseq_name": "protein CIP2A", "refseq_ac": [ { "id": "NP_766204", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766204", "type": "external" } ], "gene_names_uniprotkb": "Cip2a; C330027C09Rik; Kiaa1524", "gene_names_refseq": "C330027C09Rik; Cip2a; Kiaa1524", "protein_names_uniprotkb": "Protein CIP2A; Cancerous inhibitor of PP2A; p90 autoantigen homolog", "protein_names_refseq": "cancerous inhibitor of PP2A; p90 autoantigen homolog; protein CIP2A", "tax_id": 10090, "disease": "", "pathway": " (mmu:224171)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "12118381;18299400;20447748;21750661;21952136;22461891;31219806;34428180;35286657;36305233;36690227;36999590;38819231;39627609", "class_list": "", "function": "Acts as an inhibitor of protein phosphatase PP2A (By similarity). Promotes anchorage-independent cell growth and tumor formation by preventing dephosphorylation of MYC, thereby stabilizing MYC in human malignancies (By similarity). Together with TOPBP1, plays an essential role in the response to genome instability generated by the presence of acentric chromosome fragments derived from shattered chromosomes within micronuclei (By similarity). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, the CIP2A-TOPBP1 complex tethers chromosome fragments during mitosis to ensure clustered segregation of the fragments to a single daughter cell nucleus, facilitating re-ligation with limited chromosome scattering and loss (By similarity)., [UniProtKB, UniProtKB]; CIP2A deficiency promotes depression-like behaviors in mice through inhibition of dendritic arborization., [RefSeq, PubMed]; Chk1 Inhibition Ameliorates Alzheimer's Disease Pathogenesis and Cognitive Dysfunction Through CIP2A/PP2A Signaling., [RefSeq, PubMed]; Chronic stress induces Alzheimer's disease-like pathologies through DNA damage-Chk1-CIP2A signaling., [RefSeq, PubMed]; Data show that CIP2A expression can be systematically inhibited without severe consequences to normal mouse development and viability may have clinical relevance regarding targeting of oncogenic CIP2A for future cancer therapies., [RefSeq, PubMed]; Loss of CIP2A in Myc-overexpressing neural progenitor cells significantly reduces the ability of Myc to increase self-renewal and proliferation., [RefSeq, PubMed]; Oct4 reduction contributes to testicular injury of unilateral testicular torsion in mice model and apoptotic death of Sertoli cells through mediating CIP2A expression., [RefSeq, PubMed]; Oocytes can repair DNA damage during meiosis via a microtubule-dependent recruitment of CIP2A-MDC1-TOPBP1 complex from spindle pole to chromosomes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RQ25;Q69ZH6;Q7TPZ7", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0004864 protein phosphatase inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0036064 ciliary basal body", "go_biological_process": "GO:0007283 spermatogenesis;GO:0006974 DNA damage response;GO:2000179 positive regulation of neural precursor cell proliferation;GO:0051276 chromosome organization;GO:0141112 broken chromosome clustering", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8BWY9-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C633-1", "uniprot_id": [ { "id": "CABS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C633", "type": "external" } ], "mass": 42302.0, "length": 391, "protein_name": "Calcium-binding and spermatid-specific protein 1", "gene_name": "Cabs1", "organism": "Mouse", "refseq_name": "calcium-binding and spermatid-specific protein 1", "refseq_ac": [ { "id": "NP_081907", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081907", "type": "external" } ], "gene_names_uniprotkb": "Cabs1", "gene_names_refseq": "4931407G18Rik; Cabs1; Clph", "protein_names_uniprotkb": "Calcium-binding and spermatid-specific protein 1", "protein_names_refseq": "calcium-binding and spermatid-specific protein 1; casein-like phosphoprotein", "tax_id": 10090, "disease": "", "pathway": " (mmu:70977)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17971504;19208547;19271754;26960363;30059200;33440775;39234505", "class_list": "", "function": "4931407G18Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]; Calcium-binding protein (PubMed:19208547). Essential for maintaining the structural integrity of the sperm flagella (PubMed:33440775)., [UniProtKB, PubMed, PubMed]; It plays an important role in controlling calcium ion signaling during the acrosome reaction., [RefSeq, PubMed]; Study found for the first time that CABS1 is a calcium-binding protein that binds calcium during the maturation in the epididymis, [RefSeq, PubMed]; The metabolomics changes in epididymal lumen fluid of CABS1 deficient male mice potentially contribute to sperm deformity. Publication Status: Online-Only, [RefSeq, PubMed]; This publication characterizes the rat ortholog, casein-like phosphoprotein, and proposes a functional role in structural rearrangements during spermatogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9D4L4", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0031514 motile cilium;GO:0001669 acrosomal vesicle;GO:0097228 sperm principal piece", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030317 flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8C633-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CBC4-1", "uniprot_id": [ { "id": "CNST_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CBC4", "type": "external" } ], "mass": 76866.0, "length": 711, "protein_name": "Consortin", "gene_name": "Cnst", "organism": "Mouse", "refseq_name": "consortin", "refseq_ac": [ { "id": "NP_666217", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666217", "type": "external" } ], "gene_names_uniprotkb": "Cnst", "gene_names_refseq": "9630058J23Rik; Cnst", "protein_names_uniprotkb": "Consortin", "protein_names_refseq": "consortin", "tax_id": 10090, "disease": "", "pathway": " (mmu:226744)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;19864490;25428506;35820727", "class_list": "", "function": "Consortin is a trans-Golgi network cargo receptor for the plasma membrane targeting and recycling of connexins., [RefSeq, PubMed]; Required for targeting of connexins to the plasma membrane., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9781, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BFS5;Q8K053", "ec_number_list": [], "go_molecular_function": "GO:0071253 connexin binding;GO:0019902 phosphatase binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030133 transport vesicle;GO:0005802 trans-Golgi network;GO:0032991 protein-containing complex", "go_biological_process": "GO:0042998 positive regulation of Golgi to plasma membrane protein transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8CBC4-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CIL4-1", "uniprot_id": [ { "id": "FSAF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CIL4", "type": "external" } ], "mass": 31344.0, "length": 281, "protein_name": "40S small subunit processome assembly factor 1", "gene_name": "Fsaf1", "organism": "Mouse", "refseq_name": "40S small subunit processome assembly factor 1", "refseq_ac": [ { "id": "NP_079891", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079891", "type": "external" } ], "gene_names_uniprotkb": "Fsaf1", "gene_names_refseq": "2810004N23Rik; 3110004G14Rik; Ayu21-55; Fsaf1; Gt(pU21)55Imeg; GtAyu21-55", "protein_names_uniprotkb": "40S small subunit processome assembly factor 1", "protein_names_refseq": "40S small subunit processome assembly factor 1; Ayu21-55Imeg; Gt(Ayu21)55Imeg; uncharacterized protein C1orf131 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:66523)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;20173027;21183079;25605945;31219806;34428180", "class_list": "", "function": "Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Prevents helicase DHX37 to be recruited before post-A1 state., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UNZ3;Q9CZF4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005694 chromosome;GO:0032040 small-subunit processome", "go_biological_process": "GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8CIL4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K3M5-1", "uniprot_id": [ { "id": "CABL2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K3M5", "type": "external" } ], "mass": 52082.0, "length": 476, "protein_name": "CDK5 and ABL1 enzyme substrate 2", "gene_name": "Cables2", "organism": "Mouse", "refseq_name": "CDK5 and ABL1 enzyme substrate 2 isoform 1", "refseq_ac": [ { "id": "NP_665850", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665850", "type": "external" } ], "gene_names_uniprotkb": "Cables2", "gene_names_refseq": "Cables2; ik3-2", "protein_names_uniprotkb": "CDK5 and ABL1 enzyme substrate 2; Ik3-2; Interactor with CDK3 2", "protein_names_refseq": "CDK5 and ABL1 enzyme substrate 2 isoform 1; CDK5 and ABL1 enzyme substrate 2; interactor with CDK3 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:252966)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11955625;25428506;32779618;33949947", "class_list": "", "function": "Characterization of a bicistronic knock-in reporter mouse model for investigating the role of CABLES2 in vivo., [RefSeq, PubMed]; Disruption of entire Cables2 locus leads to embryonic lethality by diminished Rps21 gene expression and enhanced p53 pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Unknown. Probably involved in G1-S cell cycle transition., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2ABW9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0051301 cell division;GO:0007369 gastrulation;GO:0030330 DNA damage response, signal transduction by p53 class mediator;GO:0010467 gene expression", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8K3M5-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R092-3", "uniprot_id": [ { "id": "LTAP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R092", "type": "external" } ], "mass": 28691.0, "length": 253, "protein_name": "Lipid transport auxiliary protein 1", "gene_name": "Ltap1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ltap1", "gene_names_refseq": "", "protein_names_uniprotkb": "Lipid transport auxiliary protein 1; Spigot ortholog", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:99650)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "31219806;31540829;34203471", "class_list": "", "function": "Required for the formation of endoplasmic reticulum-plasma membrane junctions and functions as an accessory protein for bridge-like lipid transfer protein BLTP1, participating in lipid delivery between endoplasmic reticulum and cell membranes (By similarity). Regulates the phagocytosis of Gram-negative bacteria like L. pneumophila and E. coli, as well as Gram-positive bacteria such as S. aureus (PubMed:31540829)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UBD8;Q8BII4;Q8BIP7;Q8R240;Q9CV59;Q9CYB6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0140268 endoplasmic reticulum-plasma membrane contact site", "go_biological_process": "GO:0006909 phagocytosis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8R092-3", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R100-1", "uniprot_id": [ { "id": "CAHM5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R100", "type": "external" } ], "mass": 35285.0, "length": 309, "protein_name": "Calcium homeostasis modulator protein 5", "gene_name": "Calhm5", "organism": "Mouse", "refseq_name": "calcium homeostasis modulator protein 5", "refseq_ac": [ { "id": "NP_849239", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_849239", "type": "external" } ], "gene_names_uniprotkb": "Calhm5; Fam26e", "gene_names_refseq": "Calhm5; Fam26e", "protein_names_uniprotkb": "Calcium homeostasis modulator protein 5; Protein FAM26E", "protein_names_refseq": "calcium homeostasis modulator protein 5; family with sequence similarity 26, member E; protein FAM26E", "tax_id": 10090, "disease": "", "pathway": " (mmu:103511)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "31219806;34428180", "class_list": "", "function": "May assemble to form large pore channels with gating and ion conductance likely regulated by membrane lipids., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C3G8", "ec_number_list": [], "go_molecular_function": "GO:0005261 monoatomic cation channel activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:1904669 ATP export", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8R100-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91V08-1", "uniprot_id": [ { "id": "CLC2D_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91V08", "type": "external" } ], "mass": 23647.0, "length": 207, "protein_name": "C-type lectin domain family 2 member D", "gene_name": "Clec2d", "organism": "Mouse", "refseq_name": "C-type lectin domain family 2 member D", "refseq_ac": [ { "id": "NP_444339", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444339", "type": "external" } ], "gene_names_uniprotkb": "Clec2d; Clrb; Ocil", "gene_names_refseq": "Clec2d; Clr-b; Clrb; Ocil", "protein_names_uniprotkb": "C-type lectin domain family 2 member D; C-type lectin-related protein B; Clr-b; Lectin-like transmembrane protein; Osteoclast inhibitory lectin", "protein_names_refseq": "C lectin-related protein B; C-type lectin domain family 2 member D; C-type lectin-domain family 2 member D; C-type lectin-related protein B; lectin-like transmembrane protein; osteoclast inhibitory lectin", "tax_id": 10090, "disease": "", "pathway": " (mmu:93694)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "11278931;11398965;12374791;12858173;14990792;15123656;16751398;19144319;21183079;26740625;34428180;37872182", "class_list": "glycogene", "function": "C-type lectin receptor 2d forms homodimers and heterodimers with TLR2 to negatively regulate IRF5-mediated antifungal immunity. Publication Status: Online-Only, [RefSeq, PubMed]; Cloning and characterization of a cognate ligand, Ocil, for the inhibitory NK receptors (NKR)-P1B and NKR-P1D. Ocil/Clr-b is displayed at high levels on nearly all hematopoietic cells, in a pattern that is similar to that of class I MHC molecules., [RefSeq, PubMed]; Identification of a novel family of genes, named Clr, encoding C-type lectin-like molecules, which maps in the natural killer (NK) gene complex (NKC) on mouse Chromosome 6., [RefSeq, PubMed]; Mouse Nkrp1d and Nkrp1f bind specific C-type lectin-related (Clr) molecules. Nkrp1d mediated inhibition when recognizing Clrb, a molecule expressed in dendritic cells and macrophages. Nkrp1 and Clr are intertwined in a genetically conserved NKC region., [RefSeq, PubMed]; Receptor for KLRB1B that protects target cells against natural killer cell-mediated lysis (PubMed:14990792, PubMed:16751398). Inhibits osteoclast formation (PubMed:11278931, PubMed:12374791). Binds high molecular weight sulfated glycosaminoglycans (PubMed:15123656)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 121, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q1AFZ3;Q8VI19;Q8VI20", "ec_number_list": [], "go_molecular_function": "GO:0046703 natural killer cell lectin-like receptor binding;GO:0004888 transmembrane signaling receptor activity;GO:0030246 carbohydrate binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006968 cellular defense response;GO:0050852 T cell receptor signaling pathway;GO:0042270 protection from natural killer cell mediated cytotoxicity;GO:0045671 negative regulation of osteoclast differentiation;GO:0051132 NK T cell activation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q91V08-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010001.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91XQ5-1", "uniprot_id": [ { "id": "CHSTF_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91XQ5", "type": "external" } ], "mass": 64986.0, "length": 561, "protein_name": "Carbohydrate sulfotransferase 15", "gene_name": "Chst15", "organism": "Mouse", "refseq_name": "carbohydrate sulfotransferase 15", "refseq_ac": [ { "id": "NP_084211", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084211", "type": "external" } ], "gene_names_uniprotkb": "Chst15; Brag; Galnac4s6st; Kiaa0598", "gene_names_refseq": "4631426J05Rik; BRAG; Chst15; GalNAc4S-6ST; GalNAcS-6ST; MAd5; mKIAA0598", "protein_names_uniprotkb": "Carbohydrate sulfotransferase 15; 2.8.2.33; B-cell RAG-associated gene protein; GalNAc4S-6ST; N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase", "protein_names_refseq": "B-cell RAG-associated gene protein; GalNAc 4-sulfate 6-O-sulfotransferase; N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase; carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15; carbohydrate sulfotransferase 15", "tax_id": 10090, "disease": "", "pathway": " (mmu:77590); (R-MMU-2022870); (R-MMU-2022923)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;17051481;30084848;31219806;33143303;34428180;36210013;37248998;9754571", "class_list": "glycogene", "function": "GalNAc4S-6ST has a role during early mouse development, [RefSeq, PubMed]; Reconsideration of the Semaphorin-3A Binding Motif Found in Chondroitin Sulfate Using Galnac4s-6st-Knockout Mice. Publication Status: Online-Only, [RefSeq, PubMed]; Silencing of tumoral carbohydrate sulfotransferase 15 reactivates lymph node pancreatic cancer T cells in mice., [RefSeq, PubMed]; Sulfotransferase that transfers sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to the C-6 hydroxyl group of the GalNAc 4-sulfate residue of chondroitin sulfate A and forms chondroitin sulfate E containing GlcA-GalNAc(4,6-SO(4)) repeating units. It also transfers sulfate to a unique non-reducing terminal sequence, GalNAc(4SO4)-GlcA(2SO4)-GalNAc(6SO4), to yield a highly sulfated structure similar to the structure found in thrombomodulin chondroitin sulfate. May also act as a B-cell receptor involved in BCR ligation-mediated early activation that mediate regulatory signals key to B-cell development and/or regulation of B-cell-specific RAG expression; however such results are unclear in vivo (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 44, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q80TW4;Q8BLQ5;Q9D2N6", "ec_number_list": [ { "id": "2.8.2.33", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.33", "type": "external" } ], "go_molecular_function": "GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding;GO:0050659 N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0019319 hexose biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q91XQ5-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000010000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91ZM8-1", "uniprot_id": [ { "id": "CABP7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91ZM8", "type": "external" } ], "mass": 24453.0, "length": 215, "protein_name": "Calcium-binding protein 7", "gene_name": "Cabp7", "organism": "Mouse", "refseq_name": "calcium-binding protein 7", "refseq_ac": [ { "id": "NP_620398", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620398", "type": "external" } ], "gene_names_uniprotkb": "Cabp7; Caln2", "gene_names_refseq": "Cabp7", "protein_names_uniprotkb": "Calcium-binding protein 7; CaBP7; Calneuron II; Calneuron-2", "protein_names_refseq": "calcium-binding protein 7; calcium-binding protein CaBP7; calneuron-2; calneuron-II", "tax_id": 10090, "disease": "", "pathway": " (mmu:192650)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0032588 trans-Golgi network membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006936 muscle contraction;GO:0007528 neuromuscular junction development;GO:0060537 muscle tissue development;GO:0010467 gene expression", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q91ZM8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99JA4-1", "uniprot_id": [ { "id": "CLTR1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99JA4", "type": "external" } ], "mass": 40715.0, "length": 352, "protein_name": "Cysteinyl leukotriene receptor 1", "gene_name": "Cysltr1", "organism": "Mouse", "refseq_name": "cysteinyl leukotriene receptor 1 isoform a", "refseq_ac": [ { "id": "NP_001268788", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001268788", "type": "external" } ], "gene_names_uniprotkb": "Cysltr1; Cyslt1r; Cyslt1", "gene_names_refseq": "CysLT1R; Cyslt1; Cysltr1", "protein_names_uniprotkb": "Cysteinyl leukotriene receptor 1; CysLTR1; Cysteinyl leukotriene D4 receptor; LTD4 receptor", "protein_names_refseq": "LTD4 receptor; cysteinyl leukotriene D4 receptor; cysteinyl leukotriene receptor 1 isoform a", "tax_id": 10090, "disease": "obstructive sleep apnea (Disease Ontology:DOID:0050848); respiratory allergy (Disease Ontology:DOID:0060496); acute asthma (Disease Ontology:DOID:0080810); aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); allergic disease (Disease Ontology:DOID:1205); asthma (Disease Ontology:DOID:2841); pulmonary fibrosis (Disease Ontology:DOID:3770); rhinitis (Disease Ontology:DOID:4483); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (mmu:58861); (R-MMU-391906); (R-MMU-416476)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "11226226;11342226;11705452;11932261;34428180;36371059;36395281;38840916", "class_list": "", "function": "Cysteinyl leukotriene receptor 1 is dispensable for osteoclast differentiation and bone resorption. Publication Status: Online-Only, [RefSeq, PubMed]; Cysteinyl leukotriene receptor-1 as a potential target for host-directed therapy during chronic schistosomiasis in murine model. Publication Status: Online-Only, [RefSeq, PubMed]; Deficiency of astrocyte CysLT1R ameliorates depression-like behaviors in mice by modulating glutamate synaptic transmission., [RefSeq, PubMed]; Determination of role in enhanced vascular permeability of mice undergoing acute inflammatory responses, [RefSeq, PubMed]; Receptor for cysteinyl leukotrienes mediating constriction of the microvascular smooth muscle during an inflammatory response. This response is mediated via a G protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q544P1;Q9JJ71;Q9JK47", "ec_number_list": [], "go_molecular_function": "GO:0001631 cysteinyl leukotriene receptor activity;GO:0004974 leukotriene receptor activity;GO:0004966 galanin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0060252 positive regulation of glial cell proliferation;GO:1903409 reactive oxygen species biosynthetic process;GO:0006935 chemotaxis;GO:0007166 cell surface receptor signaling pathway;GO:0007218 neuropeptide signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q99JA4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99LI9-1", "uniprot_id": [ { "id": "CLP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99LI9", "type": "external" } ], "mass": 47738.0, "length": 425, "protein_name": "Polyribonucleotide 5'-hydroxyl-kinase Clp1", "gene_name": "Clp1", "organism": "Mouse", "refseq_name": "polyribonucleotide 5'-hydroxyl-kinase Clp1", "refseq_ac": [ { "id": "NP_598601", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598601", "type": "external" } ], "gene_names_uniprotkb": "Clp1", "gene_names_refseq": "Clp1; Heab", "protein_names_uniprotkb": "Polyribonucleotide 5'-hydroxyl-kinase Clp1; 2.7.1.78; Polyadenylation factor Clp1; Polynucleotide kinase Clp1; Pre-mRNA cleavage complex II protein Clp1", "protein_names_refseq": "ATP/GTP-binding protein; polynucleotide kinase Clp1; polyribonucleotide 5'-hydroxyl-kinase Clp1; pre-mRNA cleavage complex II protein Clp1", "tax_id": 10090, "disease": "pontocerebellar hypoplasia type 10 (Disease Ontology:DOID:0060279)", "pathway": " (mmu:98985); (R-MMU-72187); (R-MMU-73856); (R-MMU-77595); (R-MMU-9770562)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "23474986;24766809;31219806;34428180;34548404;36210013", "class_list": "", "function": "Loss of CLP1 activity results in accumulation of a novel set of small RNA fragments derived from aberrant processing of tyrosine pre-transfer RNA; these tRNA fragments sensitize cells to oxidative-stress-induced p53 activation and p53-dependent cell death, [RefSeq, PubMed]; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a key role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA (PubMed:23474986, PubMed:24766809). Its role in tRNA splicing and maturation is required for cerebellar development (PubMed:24766809). Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing., [UniProtKB, PubMed, PubMed]; The Clp1 R140H mutation alters tRNA metabolism and mRNA 3' processing in mouse models of pontocerebellar hypoplasia., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TEC7;Q3ULZ9", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.78", "type": "external" }, { "id": "2.7.7.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.19", "type": "external" }, { "id": "2.7.7.52", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.52", "type": "external" }, { "id": "3.1.3.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.32", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" } ], "go_molecular_function": "GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity;GO:0051736 ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity;GO:0005524 ATP binding;GO:0051731 polynucleotide 5'-hydroxyl-kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005849 mRNA cleavage factor complex;GO:0000214 tRNA-intron endonuclease complex", "go_biological_process": "GO:0070922 RISC complex assembly;GO:0021695 cerebellar cortex development;GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation;GO:0000379 tRNA-type intron splice site recognition and cleavage;GO:0031124 mRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q99LI9-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99MP3-1", "uniprot_id": [ { "id": "CALCB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99MP3", "type": "external" } ], "mass": 14623.0, "length": 130, "protein_name": "Calcitonin gene-related peptide 2", "gene_name": "Calcb", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Calcb", "gene_names_refseq": "", "protein_names_uniprotkb": "Calcitonin gene-related peptide 2; Beta-type CGRP; CGRP-II; CGRP2; Calcitonin gene-related peptide II", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-418555); (R-MMU-419812)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "11761712;18544925;21750661", "class_list": "", "function": "CALCB/CGRP2 is a peptide hormone that induces vasodilation mediated by the CALCRL-RAMP1 receptor complex. Dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031716 calcitonin receptor binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0051480 regulation of cytosolic calcium ion concentration;GO:1990408 calcitonin gene-related peptide receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q99MP3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQG1-1", "uniprot_id": [ { "id": "CHAC2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQG1", "type": "external" } ], "mass": 20153.0, "length": 178, "protein_name": "Putative glutathione-specific gamma-glutamylcyclotransferase 2", "gene_name": "Chac2", "organism": "Mouse", "refseq_name": "putative glutathione-specific gamma-glutamylcyclotransferase 2 isoform 2", "refseq_ac": [ { "id": "NP_001277596", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277596", "type": "external" } ], "gene_names_uniprotkb": "Chac2", "gene_names_refseq": "Chac2", "protein_names_uniprotkb": "Putative glutathione-specific gamma-glutamylcyclotransferase 2; 4.3.2.7; Cation transport regulator-like protein 2; Gamma-GCG 2", "protein_names_refseq": "ChaC, cation transport regulator homolog 2; cation transport regulator-like protein 2; gamma-GCG 2; putative glutathione-specific gamma-glutamylcyclotransferase 2 isoform 2; putative glutathione-specific gamma-glutamylcyclotransferase 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:68044); (R-MMU-174403)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "27913623;37828378", "class_list": "", "function": "Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide (PubMed:27913623). Acts specifically on glutathione, but not on other gamma-glutamyl peptides (By similarity)., [UniProtKB, UniProtKB, PubMed]; Human and mouse ChaC2 proteins purified in vitro show 10-20-fold lower catalytic efficiency than ChaC1, although they showed comparable Km values, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R3K5;Q9D1T7", "ec_number_list": [ { "id": "4.3.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:4.3.2.7", "type": "external" } ], "go_molecular_function": "GO:0061928 glutathione specific gamma-glutamylcyclotransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006751 glutathione catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CQG1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D424-1", "uniprot_id": [ { "id": "CABYR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D424", "type": "external" } ], "mass": 48333.0, "length": 453, "protein_name": "Calcium-binding tyrosine phosphorylation-regulated protein", "gene_name": "Cabyr", "organism": "Mouse", "refseq_name": "calcium-binding tyrosine phosphorylation-regulated protein isoform a", "refseq_ac": [ { "id": "NP_001035883", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035883", "type": "external" } ], "gene_names_uniprotkb": "Cabyr; Cbp86", "gene_names_refseq": "1700016C01Rik; 4933421A18Rik; CBP86; Cabyr; FSP-2", "protein_names_uniprotkb": "Calcium-binding tyrosine phosphorylation-regulated protein; Calcium-binding protein 86; Testis-specific calcium-binding protein CBP86", "protein_names_refseq": "calcium-binding protein 86; calcium-binding tyrosine phosphorylation-regulated protein isoform a; calcium-binding tyrosine phosphorylation-regulated protein; calcium-binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2); testis-specific calcium-binding protein CBP86", "tax_id": 10090, "disease": "male infertility (Disease Ontology:DOID:12336)", "pathway": " (mmu:71132)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;12801634;17855365;20485683;20731842;21750661;27802166", "class_list": "", "function": "CABYR expresses at the late stage of spermiogenesis and its isoforms oligomerize and bind with AKAPs and ropporin; which suggests that CABYR participates in the assembly of the fibrous sheath. Publication Status: Online-Only, [RefSeq, PubMed]; It is the role of CABYR in the formation of the fibrous sheath that is essential for male fertility., [RefSeq, PubMed]; May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction. May bind calcium in vitro (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q91Y41;Q91Y42", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0019904 protein domain specific binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:0019722 calcium-mediated signaling;GO:0048240 sperm capacitation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9D424-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D7S9-1", "uniprot_id": [ { "id": "CHMP5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D7S9", "type": "external" } ], "mass": 24576.0, "length": 219, "protein_name": "Charged multivesicular body protein 5", "gene_name": "Chmp5", "organism": "Mouse", "refseq_name": "charged multivesicular body protein 5", "refseq_ac": [ { "id": "NP_084090", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084090", "type": "external" } ], "gene_names_uniprotkb": "Chmp5; Snf7dc2", "gene_names_refseq": "2210412K09Rik; Chmp5", "protein_names_uniprotkb": "Charged multivesicular body protein 5; Chromatin-modifying protein 5; SNF7 domain-containing protein 2", "protein_names_refseq": "SNF7 domain-containing protein 2; charged multivesicular body protein 5; chromatin modifying protein 5; likely ortholog of H. sapiens SNF7 domain containing 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:76959); (R-MMU-917729)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "16567502;26740625;30334065;34428180;38664616", "class_list": "", "function": "CHMP5 attenuates osteoarthritis via inhibiting chondrocyte apoptosis and extracellular matrix degradation: involvement of NF-kappaB pathway. Publication Status: Online-Only, [RefSeq, PubMed]; CHMP5 regulates late endosome function downstream of MVB formation, and the loss of CHMP5 enhances signal transduction by inhibiting lysosomal degradation of activated receptors., [RefSeq, PubMed]; Our findings show that CHMP5 is a direct target of MIR429 in human colon cancer cell lines and suggest that CHMP5 up-regulation as a result of reduced MIR429 expression in DSS-induced mice colitis tissues and human UC tissues may restrict apoptosis and promote cell proliferation., [RefSeq, PubMed]; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4 (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UI64", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000815 ESCRT III complex;GO:0005828 kinetochore microtubule;GO:0000421 autophagosome membrane;GO:0005634 nucleus;GO:0005635 nuclear envelope", "go_biological_process": "GO:0001778 plasma membrane repair;GO:0010824 regulation of centrosome duplication;GO:0031468 nuclear membrane reassembly;GO:0036258 multivesicular body assembly;GO:0039702 viral budding via host ESCRT complex", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9D7S9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DAS1-1", "uniprot_id": [ { "id": "CKLF_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DAS1", "type": "external" } ], "mass": 17254.0, "length": 152, "protein_name": "Chemokine-like factor", "gene_name": "Cklf", "organism": "Mouse", "refseq_name": "chemokine-like factor isoform 4", "refseq_ac": [ { "id": "NP_001032930", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032930", "type": "external" } ], "gene_names_uniprotkb": "Cklf", "gene_names_refseq": "1700001C14Rik; 1810018M11Rik; A730028G07Rik; C32; CKLF1; CKLF3; CKLF4; CKLF5; Cklf2; Cklf6; Cklf; HSPC224; UCK-1", "protein_names_uniprotkb": "Chemokine-like factor", "protein_names_refseq": "chemokine-like factor 2; chemokine-like factor 4; chemokine-like factor 6; chemokine-like factor isoform 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:75458)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;24583145;34446558;37908119", "class_list": "", "function": "CKLF induces microglial activation via triggering defective mitophagy and mitochondrial dysfunction., [RefSeq, PubMed]; May play an important role in inflammation and regeneration of skeletal muscle (By similarity). Essential for embryonic development (PubMed:34446558)., [UniProtKB, UniProtKB, PubMed]; NF-kappaB signaling pathway was involved in the asthmatic change induced by CKLF1, among which CCR4 might play a crucial role, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T9V7;Q8BUC3;Q91ZA4;Q923S4;Q923S5", "ec_number_list": [], "go_molecular_function": "GO:0008009 chemokine activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0016020 membrane", "go_biological_process": "GO:0032940 secretion by cell;GO:0048247 lymphocyte chemotaxis;GO:0048246 macrophage chemotaxis;GO:0030593 neutrophil chemotaxis;GO:0030595 leukocyte chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9DAS1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EPW4-1", "uniprot_id": [ { "id": "CLC3A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EPW4", "type": "external" } ], "mass": 22192.0, "length": 196, "protein_name": "C-type lectin domain family 3 member A", "gene_name": "Clec3a", "organism": "Mouse", "refseq_name": "C-type lectin domain family 3 member A precursor", "refseq_ac": [ { "id": "NP_001007224", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007224", "type": "external" } ], "gene_names_uniprotkb": "Clec3a; Clecsf1; Gm796", "gene_names_refseq": "1110019O10Rik; Clec3a; Clecsf1; Gm796", "protein_names_uniprotkb": "C-type lectin domain family 3 member A; C-type lectin superfamily member 1; Cartilage-derived C-type lectin", "protein_names_refseq": "C-type calcium dependent, carbohydrate-recognition domain lectin, superfamily member 1, cartilage-derived; C-type lectin domain family 3 member A precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:403395)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29146595", "class_list": "glycogene", "function": "Authors have determined the structure, tissue distribution, and molecular function of the cartilage-specific lectin CLEC3A and show that CLEC3A binds to plasminogen and participates in tPA-mediated plasminogen activation., [RefSeq, PubMed]; Promotes cell adhesion to laminin and fibronectin., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0001503 ossification", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9EPW4-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000000000.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JHG0-1", "uniprot_id": [ { "id": "CBLN3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JHG0", "type": "external" } ], "mass": 21077.0, "length": 197, "protein_name": "Cerebellin-3", "gene_name": "Cbln3", "organism": "Mouse", "refseq_name": "cerebellin-3 precursor", "refseq_ac": [ { "id": "NP_062794", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062794", "type": "external" } ], "gene_names_uniprotkb": "Cbln3", "gene_names_refseq": "Cbln3", "protein_names_uniprotkb": "Cerebellin-3", "protein_names_refseq": "cerebellin-3 precursor; cerebellin-3; precerebellin 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:56410)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10964938;16930405;17030622;17331201;19250438;30899004", "class_list": "", "function": "Cbln3 is a secreted glycoprotein that participates in heteromeric complexes with Cbln1., [RefSeq, PubMed]; Immunohistochemical localization suggests the basis for anatomical convergence of the Cbln-GluRdelta2 signaling pathway in parallel fiber-Purkinje cell synapses, [RefSeq, PubMed]; May be involved in synaptic functions in the CNS., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0045202 synapse;GO:0043083 synaptic cleft", "go_biological_process": "GO:0099558 maintenance of synapse structure;GO:0099550 trans-synaptic signaling, modulating synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9JHG0-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JME2-1", "uniprot_id": [ { "id": "CHSTB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JME2", "type": "external" } ], "mass": 41632.0, "length": 352, "protein_name": "Carbohydrate sulfotransferase 11", "gene_name": "Chst11", "organism": "Mouse", "refseq_name": "carbohydrate sulfotransferase 11 isoform 2", "refseq_ac": [ { "id": "NP_067414", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067414", "type": "external" } ], "gene_names_uniprotkb": "Chst11", "gene_names_refseq": "1110020P09Rik; C4ST-1; C4ST1; C4ST; C4s; Chst11", "protein_names_uniprotkb": "Carbohydrate sulfotransferase 11; 2.8.2.5; C4S-1; C4ST-1; C4ST1; Chondroitin 4-O-sulfotransferase 1; Chondroitin 4-sulfotransferase 1", "protein_names_refseq": "C4S-1; carbohydrate sulfotransferase 11 isoform 2; chondroitin 4-O-sulfotransferase 1; chondroitin 4-sulfotransferase 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:58250); (R-MMU-2022870)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;10722746;12351172;16079159;37828378", "class_list": "glycogene", "function": "A gene was identified for Chondroitin-4-sulfotransferase and displays a highly specific temporal and spatial expression pattern during mouse embryogenesis, [RefSeq, PubMed]; Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues in desulfated dermatan sulfate. Preferentially sulfates in GlcA->GalNAc unit than in IdoA->GalNAc unit. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor., [UniProtKB]; Chondroitin 4-O-sulfation by C4st1 is required for proper chondroitin sulfate localization, modulation of distinct signaling pathways and cartilage growth plate morphogenesis, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 18, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9JJS2", "ec_number_list": [ { "id": "2.8.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.-", "type": "external" }, { "id": "2.8.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.5", "type": "external" } ], "go_molecular_function": "GO:0008146 sulfotransferase activity;GO:0001537 dermatan 4-sulfotransferase activity;GO:0047756 chondroitin 4-sulfotransferase activity;GO:0050659 N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0016051 carbohydrate biosynthetic process;GO:0001701 in utero embryonic development;GO:0042127 regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0007585 respiratory gaseous exchange by respiratory system", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9JME2-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000010000.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QUP4-1", "uniprot_id": [ { "id": "CHST5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QUP4", "type": "external" } ], "mass": 44537.0, "length": 395, "protein_name": "Carbohydrate sulfotransferase 5", "gene_name": "Chst5", "organism": "Mouse", "refseq_name": "carbohydrate sulfotransferase 5", "refseq_ac": [ { "id": "NP_064334", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064334", "type": "external" } ], "gene_names_uniprotkb": "Chst5; Gst4", "gene_names_refseq": "Chst5; GST-4; Gn6st-3; I-GlcNAc-6-ST", "protein_names_uniprotkb": "Carbohydrate sulfotransferase 5; 2.8.2.21; GST4; Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 4; GlcNAc6ST-3; Gn6st-3; I-GlcNAc6ST; Intestinal GlcNAc-6-sulfotransferase; Intestinal N-acetylglucosamine-6-O-sulfotransferase; N-acetylglucosamine 6-O-sulfotransferase 3; mIGn6ST", "protein_names_refseq": "GST4; I-GlcNAc6ST; N-acetylglucosamine 6-O-sulfotransferase 3; carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5; carbohydrate sulfotransferase 5; galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 4; glcNAc6ST-3; intestinal GlcNAc-6-sulfotransferase; intestinal N-acetylglucosamine-6-O-sulfotransferase; mIGn6ST", "tax_id": 10090, "disease": "macular corneal dystrophy (Disease Ontology:DOID:2565)", "pathway": " (mmu:56773); (R-MMU-2022854)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10491328;11278593;12218059;16938851;21440637;30867513;31219806", "class_list": "glycogene", "function": "Data suggest that in Chst5-KO mice, multiple chondroitin sulphate/dermatan sulphate proteoglycans have aggregated laterally and, possibly, end-to-end, with orthogonal extensions protruding from the main electron-dense stained filament., [RefSeq, PubMed]; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues of keratan (PubMed:12218059, PubMed:30867513). Involved in biosynthesis of keratan sulfate in cornea, with an impact on proteoglycan fibril organization and corneal transparency (PubMed:11278593, PubMed:16938851). Involved in biosynthesis of phosphacan (isoform of PTPRZ), a major keratan sulfate proteoglycan in the developing brain (PubMed:30867513)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 16, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.8.2.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.17", "type": "external" }, { "id": "2.8.2.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.21", "type": "external" }, { "id": "2.8.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.-", "type": "external" } ], "go_molecular_function": "GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity;GO:0045130 keratan sulfotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0006044 N-acetylglucosamine metabolic process;GO:0005975 carbohydrate metabolic process;GO:0006790 sulfur compound metabolic process;GO:0018146 keratan sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9QUP4-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZR9-1", "uniprot_id": [ { "id": "CO4A4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QZR9", "type": "external" } ], "mass": 164096.0, "length": 1682, "protein_name": "Collagen alpha-4(IV) chain", "gene_name": "Col4a4", "organism": "Mouse", "refseq_name": "collagen alpha-4(IV) chain precursor", "refseq_ac": [ { "id": "NP_031761", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031761", "type": "external" } ], "gene_names_uniprotkb": "Col4a4", "gene_names_refseq": "Col4a4; E130010M05Rik; [a]4(IV)", "protein_names_uniprotkb": "Collagen alpha-4(IV) chain", "protein_names_refseq": "collagen alpha-4(IV) chain precursor; collagen alpha-4(IV) chain; procollagen, type IV, alpha 4", "tax_id": 10090, "disease": "Alport syndrome 2 (Disease Ontology:DOID:0110033); benign familial hematuria (Disease Ontology:DOID:0111365); Alport syndrome (Disease Ontology:DOID:10983); end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (mmu:12829); (R-MMU-1650814); (R-MMU-216083)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10534397;10639489;12225806;29777959;7962065", "class_list": "", "function": "Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 3, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q149M2;Q64457", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005201 extracellular matrix structural constituent;GO:0030020 extracellular matrix structural constituent conferring tensile strength", "go_cellular_component": "GO:0031012 extracellular matrix;GO:0005604 basement membrane;GO:0005587 collagen type IV trimer", "go_biological_process": "GO:0030199 collagen fibril organization;GO:0032836 glomerular basement membrane development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9QZR9-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CXV0-1", "uniprot_id": [ { "id": "ISL2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CXV0", "type": "external" } ], "mass": 39728.0, "length": 359, "protein_name": "Insulin gene enhancer protein ISL-2", "gene_name": "Isl2", "organism": "Mouse", "refseq_name": "insulin gene enhancer protein ISL-2", "refseq_ac": [ { "id": "NP_081673", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081673", "type": "external" } ], "gene_names_uniprotkb": "Isl2", "gene_names_refseq": "3110001N10Rik; Isl2", "protein_names_uniprotkb": "Insulin gene enhancer protein ISL-2; Islet-2", "protein_names_refseq": "insulin gene enhancer protein ISL-2; islet 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:104360)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;22025611", "class_list": "glycogene", "function": "Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 8, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G5E888", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987 cis-regulatory region sequence-specific DNA binding;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0021520 spinal cord motor neuron cell fate specification;GO:0021524 visceral motor neuron differentiation;GO:0007409 axonogenesis;GO:0045665 negative regulation of neuron differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CXV0-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000000001.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91VK4-1", "uniprot_id": [ { "id": "ITM2C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91VK4", "type": "external" } ], "mass": 30482.0, "length": 269, "protein_name": "Integral membrane protein 2C", "gene_name": "Itm2c", "organism": "Mouse", "refseq_name": "integral membrane protein 2C", "refseq_ac": [ { "id": "NP_071862", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071862", "type": "external" } ], "gene_names_uniprotkb": "Itm2c", "gene_names_refseq": "3110038L02Rik; BRI3; Bricd2c; E25C; E25; ITM3; Itm2c", "protein_names_uniprotkb": "Integral membrane protein 2C; Transmembrane protein BRI3", "protein_names_refseq": "integral membrane protein 2C; integral membrane protein 3; transmembrane protein BRI3", "tax_id": 10090, "disease": "", "pathway": " (mmu:64294)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;10679242;11290423;11804340;14592447;15606899;16075062;17873332;21750661;25605945;26495903;26740625;28935714;33300544;33725478;34428180;35984892;37828378", "class_list": "", "function": "Both Itm2a and Itm2c were not detected in the epididymis and vas deferens during sexual maturation., [RefSeq, PubMed]; Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9JI06;Q9JME8", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0001540 amyloid-beta binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0005764 lysosome;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0010977 negative regulation of neuron projection development;GO:0042985 negative regulation of amyloid precursor protein biosynthetic process;GO:0030182 neuron differentiation;GO:2001238 positive regulation of extrinsic apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q91VK4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K201-1", "uniprot_id": [ { "id": "KCT2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K201", "type": "external" } ], "mass": 28050.0, "length": 259, "protein_name": "Keratinocyte-associated transmembrane protein 2", "gene_name": "9530068E07Rik; Kct2", "organism": "Mouse", "refseq_name": "keratinocyte-associated transmembrane protein 2 precursor", "refseq_ac": [ { "id": "NP_694757", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694757", "type": "external" } ], "gene_names_uniprotkb": "9530068E07Rik; Kct2", "gene_names_refseq": "9530068E07Rik; Kct2", "protein_names_uniprotkb": "Keratinocyte-associated transmembrane protein 2", "protein_names_refseq": "keratinocyte-associated transmembrane protein 2 precursor; keratinocyte-associated transmembrane protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:213673)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;30084848", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q5SVC5;Q922L7;Q9CVN1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8K201-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XKN4-1", "uniprot_id": [ { "id": "JAGN1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5XKN4", "type": "external" } ], "mass": 21102.0, "length": 183, "protein_name": "Protein jagunal homolog 1", "gene_name": "Jagn1", "organism": "Mouse", "refseq_name": "protein jagunal homolog 1 isoform 3", "refseq_ac": [ { "id": "NP_001230668", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001230668", "type": "external" } ], "gene_names_uniprotkb": "Jagn1", "gene_names_refseq": "5830427H10Rik; Jagn1", "protein_names_uniprotkb": "Protein jagunal homolog 1", "protein_names_refseq": "protein jagunal homolog 1 isoform 3; protein jagunal homolog 1", "tax_id": 10090, "disease": "severe congenital neutropenia 6 (Disease Ontology:DOID:0112134)", "pathway": " (mmu:67767)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;25129145;26882284;32930709;34428180", "class_list": "", "function": "A crucial role for Jagunal homolog 1 in humoral immunity and antibody glycosylation in mice and humans., [RefSeq, PubMed]; Endoplasmic reticulum transmembrane protein involved in vesicle-mediated transport, which is required for neutrophil function. Required for vesicle-mediated transport; it is however unclear whether it is involved in early secretory pathway or intracellular protein transport. Acts as a regulator of neutrophil function, probably via its role in vesicle-mediated transport: required for defense against fungal pathogens and for granulocyte colony-stimulating factor (GM-CSF) signaling pathway; possibly by regulating glycosylation and/or targeting of proteins contributing to the viability and migration of neutrophils., [UniProtKB, PubMed]; These results identify a novel role for Jagn1 in regulating proinsulin biosynthesis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CQ67;Q9CX52", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0030223 neutrophil differentiation;GO:1901142 insulin metabolic process;GO:0002446 neutrophil mediated immunity;GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q5XKN4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VC57-1", "uniprot_id": [ { "id": "KCTD5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VC57", "type": "external" } ], "mass": 26164.0, "length": 234, "protein_name": "BTB/POZ domain-containing protein KCTD5", "gene_name": "Kctd5", "organism": "Mouse", "refseq_name": "BTB/POZ domain-containing protein KCTD5", "refseq_ac": [ { "id": "NP_081284", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081284", "type": "external" } ], "gene_names_uniprotkb": "Kctd5", "gene_names_refseq": "2610030N08Rik; Kctd5; mKIAA0176", "protein_names_uniprotkb": "BTB/POZ domain-containing protein KCTD5", "protein_names_refseq": "BTB/POZ domain-containing protein KCTD5", "tax_id": 10090, "disease": "myoclonic dystonia (Disease Ontology:DOID:0090033)", "pathway": " (mmu:69259)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;27123980;31219806;34428180;36210013", "class_list": "", "function": "Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex (By similarity). Does not affect the function of Kv channel Kv2.1/KCNB1, Kv1.2/KCNA2, Kv4.2/KCND2 and Kv3.4/KCNC4 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UPC0", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0097602 cullin family protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8VC57-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54987-1", "uniprot_id": [ { "id": "IRG1_MOUSE", "url": "https://www.uniprot.org/uniprot/P54987", "type": "external" } ], "mass": 53758.0, "length": 488, "protein_name": "Cis-aconitate decarboxylase", "gene_name": "Acod1", "organism": "Mouse", "refseq_name": "cis-aconitate decarboxylase", "refseq_ac": [ { "id": "NP_032418", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032418", "type": "external" } ], "gene_names_uniprotkb": "Acod1; Irg1", "gene_names_refseq": "Acod1; CAD; Irg1", "protein_names_uniprotkb": "Cis-aconitate decarboxylase; 4.1.1.6; Aconitate decarboxylase 1; Aconitate decarboxylase; CAD; Cis-aconitic acid decarboxylase; Immune-responsive gene 1 protein", "protein_names_refseq": "cis-aconitate decarboxylase; cis-aconitic acid decarboxylase; immune-responsive gene 1 protein; immunoresponsive gene 1", "tax_id": 10090, "disease": "esophageal carcinoma (Disease Ontology:DOID:1107); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520)", "pathway": " (mmu:16365)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "12893884;14500577;19014335;21750661;23609450;23610393;30635240;31548418;33259501;35662396;7721348", "class_list": "", "function": "Cis-aconitate decarboxylase that catalyzes production of itaconate and is involved in the inhibition of the inflammatory response (PubMed:23609450, PubMed:23610393, PubMed:30635240, PubMed:31548418). Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages (PubMed:23609450). Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages by generating itaconate, leading to alkylation of proteins, such as TFEB (PubMed:23610393, PubMed:35662396). Involved in antiviral response following infection by flavivirus in neurons: ACOD1-mediated itaconate production inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (PubMed:30635240). Plays a role in the embryo implantation (PubMed:14500577)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; PKC pathway is induced in the uterine epithelium at implantation by the synergistic action of progesterone and estrogen and is responsible for the hormone induction of Irg1, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TAA1;Q3U8E8;Q8CBA6", "ec_number_list": [ { "id": "4.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.6", "type": "external" } ], "go_molecular_function": "GO:0047613 aconitate decarboxylase activity;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0002760 positive regulation of antimicrobial humoral response;GO:0034136 negative regulation of toll-like receptor 2 signaling pathway;GO:0071393 cellular response to progesterone stimulus;GO:0072573 tolerance induction to lipopolysaccharide;GO:0006952 defense response", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P54987-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q09TK7-1", "uniprot_id": [ { "id": "ISK11_MOUSE", "url": "https://www.uniprot.org/uniprot/Q09TK7", "type": "external" } ], "mass": 10090.0, "length": 88, "protein_name": "Serine protease inhibitor Kazal-type 11", "gene_name": "Spink11", "organism": "Mouse", "refseq_name": "serine protease inhibitor Kazal-type 11 precursor", "refseq_ac": [ { "id": "NP_001041682", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041682", "type": "external" } ], "gene_names_uniprotkb": "Spink11", "gene_names_refseq": "9230112K01Rik; Spink11", "protein_names_uniprotkb": "Serine protease inhibitor Kazal-type 11", "protein_names_refseq": "serine protease inhibitor Kazal-type 11 precursor; serine protease inhibitor Kazal-type 11", "tax_id": 10090, "disease": "", "pathway": " (mmu:433181)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16930550;21750661", "class_list": "", "function": "Probable serine protease inhibitor., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B9EJS7;Q3UW03", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q09TK7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BRV5-1", "uniprot_id": [ { "id": "K1671_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BRV5", "type": "external" } ], "mass": 34668.0, "length": 308, "protein_name": "Uncharacterized protein KIAA1671", "gene_name": "2900026A02Rik; Kiaa1671", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "2900026A02Rik; Kiaa1671", "gene_names_refseq": "", "protein_names_uniprotkb": "Uncharacterized protein KIAA1671", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:243219)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17242355;20485683;21750661;32848054;40885482", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B2RVT5;Q5DTV9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005929 cilium", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BRV5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DCB8-1", "uniprot_id": [ { "id": "ISCA2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DCB8", "type": "external" } ], "mass": 16718.0, "length": 154, "protein_name": "Iron-sulfur cluster assembly 2 homolog, mitochondrial", "gene_name": "Isca2", "organism": "Mouse", "refseq_name": "iron-sulfur cluster assembly 2 homolog, mitochondrial precursor", "refseq_ac": [ { "id": "NP_083139", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083139", "type": "external" } ], "gene_names_uniprotkb": "Isca2; Hbld1", "gene_names_refseq": "0710001C05Rik; 5730594E03Rik; Hbld1; Isca2", "protein_names_uniprotkb": "Iron-sulfur cluster assembly 2 homolog, mitochondrial; HESB-like domain-containing protein 1", "protein_names_refseq": "HESB like domain containing 1; HESB-like domain-containing protein 1; iron-sulfur cluster assembly 2 homolog, mitochondrial precursor; iron-sulfur cluster assembly 2 homolog, mitochondrial", "tax_id": 10090, "disease": "multiple mitochondrial dysfunctions syndrome 4 (Disease Ontology:DOID:0080136)", "pathway": " (mmu:74316); (R-MMU-1362409); (R-MMU-9854311)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "21750661;24577088;25428506;28492233", "class_list": "", "function": "Data suggest that miR-210 induced repression of ISCU1/2 may contribute to HIF-1alpha-triggered alterations in neuronal energy metabolism after nickel exposure. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. May be involved in the binding of an intermediate of Fe/S cluster assembly., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The data suggest that cellular processes with different requirements for ISCA1, ISCA2 and ISCA1-ISCA2 complex seem to exist. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005506 iron ion binding;GO:0042802 identical protein binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0051537 2 iron, 2 sulfur cluster binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:1990229 iron-sulfur cluster assembly complex;GO:0120510 mitochondrial [4Fe-4S] assembly complex", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9DCB8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P1C1-1", "uniprot_id": [ { "id": "IPPK_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P1C1", "type": "external" } ], "mass": 55928.0, "length": 489, "protein_name": "Inositol-pentakisphosphate 2-kinase", "gene_name": "Ippk", "organism": "Mouse", "refseq_name": "inositol-pentakisphosphate 2-kinase isoform a", "refseq_ac": [ { "id": "NP_951011", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_951011", "type": "external" } ], "gene_names_uniprotkb": "Ippk", "gene_names_refseq": "1810043M15Rik; InsP6; Ippk", "protein_names_uniprotkb": "Inositol-pentakisphosphate 2-kinase; 2.7.1.158; Inositol-1,3,4,5,6-pentakisphosphate 2-kinase; Ins(1,3,4,5,6)P5 2-kinase; InsP5 2-kinase", "protein_names_refseq": "inositol-pentakisphosphate 2-kinase isoform a; inositol-pentakisphosphate 2-kinase; ins(1,3,4,5,6)P5 2-kinase; insP5 2-kinase", "tax_id": 10090, "disease": "", "pathway": " (mmu:75678); (R-MMU-1855167); (R-MMU-1855191)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "15939868;21750661;28429156;28450399", "class_list": "", "function": "Crystallization and preliminary x-ray diffraction analysis of a mouse inositol 1,3,4,5,6-pentakisphosphate 2-kinase has been reported., [RefSeq, PubMed]; Findings have uncovered distinct features of a mammalian IP5 2-K and set the stage for investigations into protein-protein or protein-RNA interactions important for IP5 2-K function and activity, [RefSeq, PubMed]; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-induced apoptosis., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V3Z0", "ec_number_list": [ { "id": "2.7.1.158", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.158", "type": "external" } ], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0035299 inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:1901838 positive regulation of transcription of nucleolar large rRNA by RNA polymerase I;GO:0032958 inositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6P1C1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D924-1", "uniprot_id": [ { "id": "ISCA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D924", "type": "external" } ], "mass": 14188.0, "length": 129, "protein_name": "Iron-sulfur cluster assembly 1 homolog, mitochondrial", "gene_name": "Isca1", "organism": "Mouse", "refseq_name": "iron-sulfur cluster assembly 1 homolog, mitochondrial precursor", "refseq_ac": [ { "id": "NP_081197", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081197", "type": "external" } ], "gene_names_uniprotkb": "Isca1; Hbld2", "gene_names_refseq": "1810010A06Rik; Hbld2; Isca1", "protein_names_uniprotkb": "Iron-sulfur cluster assembly 1 homolog, mitochondrial; HESB-like domain-containing protein 2; Iron-sulfur assembly protein IscA", "protein_names_refseq": "HESB like domain containing 2; HESB-like domain-containing protein 2; iron-sulfur assembly protein IscA; iron-sulfur cluster assembly 1 homolog, mitochondrial precursor; iron-sulfur cluster assembly 1 homolog, mitochondrial", "tax_id": 10090, "disease": "multiple mitochondrial dysfunctions syndrome 5 (Disease Ontology:DOID:0080274)", "pathway": " (mmu:69046); (R-MMU-1362409); (R-MMU-9854311)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "19656490;21750661;24577088;28492233", "class_list": "", "function": "Data suggest that miR-210 induced repression of ISCU1/2 may contribute to HIF-1alpha-triggered alterations in neuronal energy metabolism after nickel exposure. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly., [UniProtKB, UniProtKB]; Required for functional heme biosynthesis in erythroid cells., [RefSeq, PubMed]; The data suggest that cellular processes with different requirements for ISCA1, ISCA2 and ISCA1-ISCA2 complex seem to exist. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5SZT5", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051537 2 iron, 2 sulfur cluster binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:1990229 iron-sulfur cluster assembly complex;GO:0120510 mitochondrial [4Fe-4S] assembly complex", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9D924-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CEZ0-1", "uniprot_id": [ { "id": "KCTD2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CEZ0", "type": "external" } ], "mass": 30145.0, "length": 266, "protein_name": "BTB/POZ domain-containing protein KCTD2", "gene_name": "Kctd2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Kctd2", "gene_names_refseq": "", "protein_names_uniprotkb": "BTB/POZ domain-containing protein KCTD2", "protein_names_refseq": "", "tax_id": 10090, "disease": "myoclonic dystonia (Disease Ontology:DOID:0090033)", "pathway": " (mmu:70382)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0097602 cullin family protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8CEZ0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AFS3-1", "uniprot_id": [ { "id": "ELAP1_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AFS3", "type": "external" } ], "mass": 110682.0, "length": 1009, "protein_name": "Endosome/lysosome-associated apoptosis and autophagy regulator 1", "gene_name": "Elapor1", "organism": "Mouse", "refseq_name": "endosome/lysosome-associated apoptosis and autophagy regulator 1 isoform 2", "refseq_ac": [ { "id": "NP_001028476", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028476", "type": "external" } ], "gene_names_uniprotkb": "Elapor1; 5330417C22Rik; Kiaa1324", "gene_names_refseq": "5330417C22Rik; Elapor1; Iir; Inceptor", "protein_names_uniprotkb": "Endosome/lysosome-associated apoptosis and autophagy regulator 1", "protein_names_refseq": "endosome/lysosome-associated apoptosis and autophagy regulator 1 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:229722)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;34428180;34816763", "class_list": "", "function": "ELAPOR1 is a secretory granule maturation-promoting factor that is lost during paligenosis., [RefSeq, PubMed]; May protect cells from cell death by inducing cytosolic vacuolization and up-regulating the autophagy pathway. May play a role in apoptosis and cell proliferation through its interaction with HSPA5., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "A2AFS2;Q3UTM2;Q69ZL9;Q7TS96;Q8R215", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005765 lysosomal membrane;GO:0005789 endoplasmic reticulum membrane;GO:0031902 late endosome membrane", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0044090 positive regulation of vacuole organization;GO:0009267 cellular response to starvation;GO:2000786 positive regulation of autophagosome assembly", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A2AFS3-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80V86-1", "uniprot_id": [ { "id": "INT8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80V86", "type": "external" } ], "mass": 113353.0, "length": 995, "protein_name": "Integrator complex subunit 8", "gene_name": "Ints8", "organism": "Mouse", "refseq_name": "integrator complex subunit 8", "refseq_ac": [ { "id": "NP_001153067", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153067", "type": "external" } ], "gene_names_uniprotkb": "Ints8", "gene_names_refseq": "2810013E07Rik; D130008D20Rik; Ints8", "protein_names_uniprotkb": "Integrator complex subunit 8; Int8", "protein_names_refseq": "int8; integrator complex subunit 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:72656); (R-MMU-6807505)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;21750661;28542170;31219806;34428180;35820727", "class_list": "", "function": "Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). Within the integrator complex, INTS8 is required for the recruitment of protein phosphatase 2A (PP2A) to transcription pause-release checkpoint., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2API4;Q3TEM3;Q3TNW0;Q6PFD3;Q810I3;Q8BQJ8;Q8BT91", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0032039 integrator complex;GO:0160232 INTAC complex;GO:0005694 chromosome", "go_biological_process": "GO:0034243 regulation of transcription elongation by RNA polymerase II;GO:0016180 snRNA processing;GO:0071168 protein localization to chromatin;GO:0034472 snRNA 3'-end processing;GO:0160240 RNA polymerase II transcription initiation surveillance", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q80V86-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6H690-1", "uniprot_id": [ { "id": "DC11L_MOUSE", "url": "https://www.uniprot.org/uniprot/A6H690", "type": "external" } ], "mass": 95956.0, "length": 825, "protein_name": "Dynein regulatory complex subunit 11-like", "gene_name": "Drc11l; Iqca1l", "organism": "Mouse", "refseq_name": "dynein regulatory complex subunit 11-like", "refseq_ac": [ { "id": "NP_808344", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808344", "type": "external" } ], "gene_names_uniprotkb": "Drc11l; Iqca1l; 4931409K22Rik; Iqca1l; Iqca1p1", "gene_names_refseq": "4931409K22Rik; Drc11l; Iqca1l; Iqca1p1", "protein_names_uniprotkb": "Dynein regulatory complex subunit 11-like; IQ and AAA domain-containing protein 1-like; Protein IQCA1P1", "protein_names_refseq": "IQ motif containing with AAA domain 1 like; dynein regulatory complex subunit 11-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:231045)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9EHI7;E9QN17;Q8CDM7", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A6H690-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62168-1", "uniprot_id": [ { "id": "K1H2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62168", "type": "external" } ], "mass": 46422.0, "length": 407, "protein_name": "Keratin, type I cuticular Ha2", "gene_name": "Krt32", "organism": "Mouse", "refseq_name": "keratin, type I cuticular Ha2", "refseq_ac": [ { "id": "NP_001152846", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152846", "type": "external" } ], "gene_names_uniprotkb": "Krt32; Hka2; Krt1-2; Krtha2", "gene_names_refseq": "Ha3; Hka2; K32; Krt1-2; Krt32; Krtha2", "protein_names_uniprotkb": "Keratin, type I cuticular Ha2; Hair keratin, type I Ha2; K32; Keratin-32", "protein_names_refseq": "hair keratin, type I Ha2; keratin complex 1, acidic, gene 2; keratin, type I cuticular Ha2", "tax_id": 10090, "disease": "autosomal recessive intellectual developmental disorder 43 (Disease Ontology:DOID:0081207); Wiskott-Aldrich syndrome (Disease Ontology:DOID:9169)", "pathway": " (mmu:16670); (R-MMU-6805567); (R-MMU-6809371)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "21750661;25428506;39048559;7514534", "class_list": "", "function": "Loss-of-function mutations in Keratin 32 gene disrupt skin immune homeostasis in pityriasis rubra pilaris. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q148N4", "ec_number_list": [], "go_molecular_function": "GO:0030280 structural constituent of skin epidermis;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0045095 keratin filament;GO:0005882 intermediate filament", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0045109 intermediate filament organization;GO:0002009 morphogenesis of an epithelium", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q62168-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54982-1", "uniprot_id": [ { "id": "KCNU1_MOUSE", "url": "https://www.uniprot.org/uniprot/O54982", "type": "external" } ], "mass": 126912.0, "length": 1121, "protein_name": "Potassium channel subfamily U member 1", "gene_name": "Kcnu1", "organism": "Mouse", "refseq_name": "potassium channel subfamily U member 1", "refseq_ac": [ { "id": "NP_032458", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032458", "type": "external" } ], "gene_names_uniprotkb": "Kcnu1; Kcnma3; Ksper; Slo3", "gene_names_refseq": "Kcnma3; Kcnu1; Slo3; mSlo3", "protein_names_uniprotkb": "Potassium channel subfamily U member 1; Calcium-activated potassium channel subunit alpha-3; Calcium-activated potassium channel, subfamily M subunit alpha-3; KSper; Pore-forming subunit of the sperm-specific alkalization activated K(+) current; Slowpoke homolog 3; mSlo3; pH-sensitive maxi potassium channel", "protein_names_refseq": "KSper; calcium-activated potassium channel subunit alpha-3; calcium-activated potassium channel, subfamily M subunit alpha-3; pH-sensitive maxi potassium channel; pore-forming subunit of the sperm-specific alkalization activated K(+) current; potassium channel subfamily U member 1; potassium large conductance pH-sensitive channel, subfamily M, alpha member 3; slowpoke homolog 3", "tax_id": 10090, "disease": "withdrawal disorder (Disease Ontology:DOID:0060001); paroxysmal nonkinesigenic dyskinesia 3 (Disease Ontology:DOID:0070442); spermatogenic failure 79 (Disease Ontology:DOID:0070578); heart conduction disease (Disease Ontology:DOID:10273); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); alcohol use disorder (Disease Ontology:DOID:1574); substance-related disorder (Disease Ontology:DOID:303)", "pathway": " (mmu:16532); (R-MMU-1300642)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "11696614;11723163;12192410;15201331;16940554;16940555;19338774;20138882;21427226;21750661;22084117;23129643;25675513;31270758;35551387;38637987;9452476", "class_list": "", "function": "A structurally new Mg(2+)-binding site in the RCK/Rossman fold domain -- an intracellular structural motif that immediately follows the activation gate S6 helix -- is responsible for Mg(2+)-dependent activation, [RefSeq, PubMed]; Increases in pH increase the fraction of more rapidly opening channels., [RefSeq, PubMed]; Native current observed in sperm is indeed carried by Slo3 channels., [RefSeq, PubMed]; Study confirms that expression of full-length Slo3 is sperm-specific but warns against developing contraceptive drugs targeting the C-terminal tail of Slo3 channels., [RefSeq, PubMed]; Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+) (PubMed:25675513, PubMed:9452476). Represents the primary spermatozoan K(+) current. The channel underlies a pH-triggered membrane hyperpolarization during the process of sperm capacitation, as sperm encounter the alkaline environment near the ovum in the female reproductive tract, thereby playing an essential for male fertility (PubMed:11696614, PubMed:11723163, PubMed:15201331, PubMed:16940554, PubMed:16940555, PubMed:20138882, PubMed:21427226, PubMed:23129643, PubMed:25675513, PubMed:9452476)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Transmembrane determinants of voltage-gating differences between BK (Slo1) and Slo3 channels., [RefSeq, PubMed]; Voltage and pH regulate a closed-open conformational change in a largely independent fashion, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3Z5P2;G3X9P7", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005267 potassium channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0036126 sperm flagellum;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0009566 fertilization;GO:0050821 protein stabilization;GO:0006813 potassium ion transport;GO:0022414 reproductive process;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "O54982-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z690-1", "uniprot_id": [ { "id": "IZUM4_MOUSE", "url": "https://www.uniprot.org/uniprot/D3Z690", "type": "external" } ], "mass": 26332.0, "length": 227, "protein_name": "Izumo sperm-egg fusion protein 4", "gene_name": "Izumo4", "organism": "Mouse", "refseq_name": "izumo sperm-egg fusion protein 4 precursor", "refseq_ac": [ { "id": "NP_082105", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082105", "type": "external" } ], "gene_names_uniprotkb": "Izumo4", "gene_names_refseq": "9030607L17Rik; Izumo4", "protein_names_uniprotkb": "Izumo sperm-egg fusion protein 4", "protein_names_refseq": "izumo sperm-egg fusion protein 4 precursor; izumo sperm-egg fusion protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:71564); (R-MMU-1300645)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6PEP3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "D3Z690-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CAC8-1", "uniprot_id": [ { "id": "ISK10_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CAC8", "type": "external" } ], "mass": 18520.0, "length": 162, "protein_name": "Serine protease inhibitor Kazal-type 10", "gene_name": "Spink10", "organism": "Mouse", "refseq_name": "serine protease inhibitor Kazal-type 10", "refseq_ac": [ { "id": "NP_808497", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808497", "type": "external" } ], "gene_names_uniprotkb": "Spink10", "gene_names_refseq": "A230091H23Rik; Spink10", "protein_names_uniprotkb": "Serine protease inhibitor Kazal-type 10", "protein_names_refseq": "serine protease inhibitor Kazal-type 10", "tax_id": 10090, "disease": "", "pathway": " (mmu:328971)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16930550;21750661", "class_list": "", "function": "Probable serine protease inhibitor., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0016020 membrane;GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8CAC8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TA59-1", "uniprot_id": [ { "id": "JMJD8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TA59", "type": "external" } ], "mass": 30388.0, "length": 269, "protein_name": "JmjC domain-containing protein 8", "gene_name": "Jmjd8", "organism": "Mouse", "refseq_name": "jmjC domain-containing protein 8 precursor", "refseq_ac": [ { "id": "NP_082377", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082377", "type": "external" } ], "gene_names_uniprotkb": "Jmjd8", "gene_names_refseq": "2610003J06Rik; Jmjd8", "protein_names_uniprotkb": "JmjC domain-containing protein 8; Jumonji domain-containing protein 8", "protein_names_refseq": "jmjC domain-containing protein 8 precursor; jmjC domain-containing protein 8; jumonji domain-containing protein 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:72106)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;21750661;27199445;34428180;37054705;37211325", "class_list": "", "function": "ER-localized JmjC domain-containing protein JMJD8 targets STING to promote immune evasion and tumor growth in breast cancer., [RefSeq, PubMed]; Functions as a positive regulator of TNF-induced NF-kappaB signaling (By similarity). Regulates angiogenesis and cellular metabolism through interaction with PKM (PubMed:27199445)., [UniProtKB, UniProtKB, PubMed]; Functions as a positive regulator of TNF-induced NF-kappaB signaling. Regulates angiogenesis and cellular metabolism through interaction with PKM., [UniProtKB, UniProtKB]; JMJD8 regulates neuropathic pain by affecting spinal cord astrocyte differentiation., [RefSeq, PubMed]; Jmjd8 is upregulated during endothelial differentiation and regulates endothelial sprouting and metabolism by interacting with pyruvate kinase M2., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A0A3B2W707;Q3U1Q1;Q91XD9;Q9D0L5", "ec_number_list": [], "go_molecular_function": "GO:0000987 cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:1903672 positive regulation of sprouting angiogenesis;GO:0006110 regulation of glycolytic process;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0002040 sprouting angiogenesis;GO:0045333 cellular respiration", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q3TA59-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CR56-1", "uniprot_id": [ { "id": "KBRS2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CR56", "type": "external" } ], "mass": 21494.0, "length": 191, "protein_name": "NF-kappa-B inhibitor-interacting Ras-like protein 2", "gene_name": "Nkiras2", "organism": "Mouse", "refseq_name": "NF-kappa-B inhibitor-interacting Ras-like protein 2", "refseq_ac": [ { "id": "NP_082300", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082300", "type": "external" } ], "gene_names_uniprotkb": "Nkiras2", "gene_names_refseq": "2410003M04Rik; 4930527H08Rik; D630018G21Rik; KBRAS2; Nkiras2", "protein_names_uniprotkb": "NF-kappa-B inhibitor-interacting Ras-like protein 2; I-kappa-B-interacting Ras-like protein 2; Kappa B-Ras protein 2; KappaB-Ras2", "protein_names_refseq": "I-kappa-B-interacting Ras-like protein 2; NF-kappa-B inhibitor-interacting Ras-like protein 2; kappa B-Ras protein 2; kappaB-Ras2", "tax_id": 10090, "disease": "", "pathway": " (mmu:71966); (R-MMU-1810476); (R-MMU-445989); (R-MMU-933542)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "20639196;21750661;34667224", "class_list": "", "function": "Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity)., [UniProtKB]; K15 promoter-driven enforced expression of NKIRAS exhibits tumor suppressive activity against the development of DMBA/TPA-induced skin tumors. Publication Status: Online-Only, [RefSeq, PubMed]; KappaB-Ras2 is a nuclear-cytoplasmic small GTPase that inhibits NF-kappaB activation through the suppression of transcriptional activation of p65/RelA., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BWG0", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0032794 GTPase activating protein binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006954 inflammatory response;GO:0043129 surfactant homeostasis;GO:0048286 lung alveolus development;GO:0043124 negative regulation of canonical NF-kappaB signal transduction;GO:0043122 regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CR56-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CEC5-1", "uniprot_id": [ { "id": "KBRS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CEC5", "type": "external" } ], "mass": 21662.0, "length": 192, "protein_name": "NF-kappa-B inhibitor-interacting Ras-like protein 1", "gene_name": "Nkiras1", "organism": "Mouse", "refseq_name": "NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 2", "refseq_ac": [ { "id": "NP_001303640", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001303640", "type": "external" } ], "gene_names_uniprotkb": "Nkiras1", "gene_names_refseq": "2400004O09Rik; KBRAS1; Nkiras1; kappaB-Ras1", "protein_names_uniprotkb": "NF-kappa-B inhibitor-interacting Ras-like protein 1; I-kappa-B-interacting Ras-like protein 1; Kappa B-Ras protein 1; KappaB-Ras1", "protein_names_refseq": "I-kappa-B-interacting Ras-like protein 1; NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 2; NF-kappa-B inhibitor-interacting Ras-like protein 1; kappa B-Ras protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:69721); (R-MMU-1810476); (R-MMU-445989); (R-MMU-933542)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "10657303;16452087;21750661;31219806", "class_list": "", "function": "Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JKV3", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0032794 GTPase activating protein binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0043129 surfactant homeostasis;GO:0048286 lung alveolus development;GO:0043124 negative regulation of canonical NF-kappaB signal transduction;GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway;GO:0032484 Ral protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8CEC5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61702-1", "uniprot_id": [ { "id": "ITIH1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61702", "type": "external" } ], "mass": 101067.0, "length": 907, "protein_name": "Inter-alpha-trypsin inhibitor heavy chain H1", "gene_name": "Itih1", "organism": "Mouse", "refseq_name": "inter-alpha-trypsin inhibitor heavy chain H1 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001293007", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001293007", "type": "external" } ], "gene_names_uniprotkb": "Itih1", "gene_names_refseq": "ITI-HC1; Intin1; Itih-1; Itih1", "protein_names_uniprotkb": "Inter-alpha-trypsin inhibitor heavy chain H1; ITI heavy chain H1; ITI-HC1; Inter-alpha-inhibitor heavy chain 1", "protein_names_refseq": "inter-alpha (globulin) inhibitor, H1 polypeptide; inter-alpha-trypsin inhibitor heavy chain H1 isoform 2 precursor; inter-alpha-trypsin inhibitor heavy chain H1", "tax_id": 10090, "disease": "", "pathway": " (mmu:16424)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;16944957;17330941;21750661;23386199;26495903;30084848;31219806;31597753;34428180;37507081;7534067", "class_list": "", "function": "May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes., [UniProtKB, UniProtKB, UniProtKB]; This gene encodes a heavy chain of inter-alpha trypsin inhibitor (IaI) family of plasma serine protease inhibitors. IaI proteins are protein-glycosaminoglycan-protein complexes comprised of two heavy chains and a light chain. The encoded protein covalently associates with the light chain via a chondroitin sulfate moiety. Intravenous administration of the encoded protein improved survival of mice after infection with Escherichia coli. This gene is located adjacent to two other IaI heavy chain genes. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature protein. [provided by RefSeq, Oct 2015]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 1, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q3UEI9", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0030246 carbohydrate binding;GO:0005540 hyaluronic acid binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix", "go_biological_process": "GO:0030198 extracellular matrix organization;GO:0030212 hyaluronan metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q61702-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1100000001011.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88335-1", "uniprot_id": [ { "id": "KCNJ1_MOUSE", "url": "https://www.uniprot.org/uniprot/O88335", "type": "external" } ], "mass": 42776.0, "length": 372, "protein_name": "ATP-sensitive inward rectifier potassium channel 1", "gene_name": "Kcnj1", "organism": "Mouse", "refseq_name": "ATP-sensitive inward rectifier potassium channel 1 isoform 2", "refseq_ac": [ { "id": "NP_062633", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062633", "type": "external" } ], "gene_names_uniprotkb": "Kcnj1", "gene_names_refseq": "Kcnj1; Kir1.1; ROMK; Romk2", "protein_names_uniprotkb": "ATP-sensitive inward rectifier potassium channel 1; ATP-regulated potassium channel ROM-K; Inward rectifier K(+) channel Kir1.1; Potassium channel, inwardly rectifying subfamily J member 1", "protein_names_refseq": "ATP-regulated potassium channel ROM-K; ATP-sensitive inward rectifier potassium channel 1 isoform 2; ATP-sensitive inward rectifier potassium channel 1; inward rectifier K(+) channel Kir1.1; inwardly rectifying potassium channel ROMK-2; potassium channel, inwardly rectifying subfamily J member 1", "tax_id": 10090, "disease": "Bartter disease type 2 (Disease Ontology:DOID:0110143); nephrotic syndrome (Disease Ontology:DOID:1184)", "pathway": " (mmu:56379); (R-MMU-1296067)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "12122007;12130653;12684516;21750661;29092859;29667910;32004507", "class_list": "", "function": "Absence of small conductance K+ channel (SK) activity in apical membranes of thick ascending limb and cortical collecting duct in knockout mice a model for bartter's disease__, [RefSeq, PubMed]; Global knockout of ROMK potassium channel worsens cardiac ischemia-reperfusion injury but cardiomyocyte-specific knockout does not: Implications for the identity of mitoKATP., [RefSeq, PubMed]; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium. In the kidney, probably plays a major role in potassium homeostasis., [UniProtKB, UniProtKB]; Knockout mice have impaired renal NaCl absorption; a model for type II Bartter's syndrome, [RefSeq, PubMed]; ROMK is expressed in the urinary tract at both protein and mRNA levels. Significant enlargement and hypertrophy of the bladder may contribute to hydronephrosis in male ROMK KO mice., [RefSeq, PubMed]; SGK-1 phosphorylation of ROMK drives expression on the plasmalemma; because SGK-1 is an early aldosterone-induced gene, results suggest a possible molecular mechanism for aldosterone-dependent regulation of the secretory potassium channel in the kidney, [RefSeq, PubMed]; WNK1, but not WNK4, is required for high potassium intake-induced stimulation of ROMK activity in convoluted kidney tubules., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0005267 potassium channel activity;GO:0015272 ATP-activated inward rectifier potassium channel activity;GO:0042277 peptide binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0072359 circulatory system development;GO:0043066 negative regulation of apoptotic process;GO:0001822 kidney development;GO:0001894 tissue homeostasis;GO:0009791 post-embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O88335-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91ZI8-1", "uniprot_id": [ { "id": "IOD3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91ZI8", "type": "external" } ], "mass": 34111.0, "length": 304, "protein_name": "Thyroxine 5-deiodinase", "gene_name": "Dio3", "organism": "Mouse", "refseq_name": "thyroxine 5-deiodinase", "refseq_ac": [ { "id": "NP_742117", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742117", "type": "external" } ], "gene_names_uniprotkb": "Dio3", "gene_names_refseq": "Dio3", "protein_names_uniprotkb": "Thyroxine 5-deiodinase; 1.21.99.3; 5DIII; DIOIII; Type 3 DI; Type III iodothyronine deiodinase", "protein_names_refseq": "5DIII; DIOIII; thyroxine 5-deiodinase; type 3 DI; type III iodothyronine deiodinase; type-III 5'-deiodinase", "tax_id": 10090, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); linear skin defects with multiple congenital anomalies 3 (Disease Ontology:DOID:0111876); nuclear type mitochondrial complex I deficiency 30 (Disease Ontology:DOID:0112098); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (mmu:107585); (R-MMU-350864)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "12399446;12586753;16410833;21750661;9886816", "class_list": "", "function": "Findings show dramatic age and thyroid state-dependent changes in the expression of iodothyronine deiodinase D1, D2 and D3 in central and peripheral tissues of mice during the first 3 wk of life, [RefSeq, PubMed]; Plays a crucial role in the metabolism of thyroid hormones (TH) and has specific roles in TH activation and inactivation by deiodination (By similarity). Catalyzes the deiodination of L-thyroxine (T4) to 3,3',5'-triiodothyronine (rT3), 3,5,3'-triiodothyronine (T3) to 3,3'-diiodothyronine (3,3'-T2), 3,5-diiodothyronine (3,5-T2) to 3-monoiodothyronine (3-T1), rT3 to 3',5'-diiodothyronine (3',5'-T2) and 3,3'-T2 to 3'-monoiodothyronine (3'-T1) via inner-ring deiodination (IRD) (By similarity). Catalyzes the deiodination of 3-T1 to L-thyronine (T0) via outer-ring deiodination (ORD) (By similarity). Catalyzes the tyrosyl ring deiodinations of 3,3',5,5'-tetraiodothyronamine, 3,3',5'-triiodothyronamine, 3,5,3'-triiodothyronamine, 3,5-diiodothyronamine, 3,3'-diiodothyronamine and 3-iodothyronamine (By similarity)., [UniProtKB, UniProtKB]; Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine)., [UniProtKB, UniProtKB]; Results demonstrate that the lack of iodothyronine deiodinase type III function results in neonatal thyrotoxicosis followed later by central hypothyroidism that persists throughout life., [RefSeq, PubMed]; The Dio3 gene is subject to genomic imprinting and preferentially expressed from the paternal allele in the mouse fetus; also identified a gene that is transcribed antisense from the Dio3 locus, [RefSeq, PubMed]; This is an intronless, imprinted gene that is preferentially expressed from the paternal allele in the mouse fetus. The encoded protein belongs to the iodothyronine deiodinase family, and catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5' triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. It is highly expressed in placenta, fetal and neonatal tissues, and thought to prevent premature exposure of developing fetal tissues to adult levels of thyroid hormones. It thus plays a critical role in mammalian development by regulating circulating fetal thyroid hormone concentration. Knockout mice lacking this gene exhibit severe abnormalities related to development and reproduction. This protein is a selenoprotein, containing the rare selenocysteine (Sec) amino acid at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jun 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3UY28;Q3UKD2", "ec_number_list": [ { "id": "1.21.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.21.99.3", "type": "external" }, { "id": "1.21.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.21.99.4", "type": "external" } ], "go_molecular_function": "GO:0033798 thyroxine 5-deiodinase activity;GO:0004800 thyroxine 5'-deiodinase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0042404 thyroid hormone catabolic process;GO:0001666 response to hypoxia;GO:0006915 apoptotic process;GO:0042446 hormone biosynthetic process;GO:0040018 positive regulation of multicellular organism growth", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q91ZI8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08717-1", "uniprot_id": [ { "id": "INHBE_MOUSE", "url": "https://www.uniprot.org/uniprot/O08717", "type": "external" } ], "mass": 39002.0, "length": 350, "protein_name": "Inhibin beta E chain", "gene_name": "Inhbe", "organism": "Mouse", "refseq_name": "inhibin beta E chain preproprotein", "refseq_ac": [ { "id": "NP_032408", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032408", "type": "external" } ], "gene_names_uniprotkb": "Inhbe", "gene_names_refseq": "Inhbe", "protein_names_uniprotkb": "Inhibin beta E chain; Activin beta-E chain", "protein_names_refseq": "activin beta-E chain; inhibin beta E chain preproprotein; inhibin beta E chain", "tax_id": 10090, "disease": "", "pathway": " (mmu:16326); (R-MMU-209822)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "29596463;30380411;31361958;37523551;37922570;39948368;8941337;9070865", "class_list": "", "function": "A function of activin E to stimulate energy expenditure through brown and beige adipocyte activation, is reported., [RefSeq, PubMed]; Activin E is a homodimer of INHBE secreted by the liver that plays a crucial role in regulating metabolic homeostasis particularly in lipid metabolism and energy homeostasis. Plays a central role in the regulation of adipose tissue lipolysis by preventing the influx of fatty acids from adipose tissue into the liver (PubMed:39948368). Mechanistically, signals via ACVR1C to activate SMAD2/3 signaling, suppressing PPARG target genes in adipose tissue, thereby reducing liver lipid content and improving glycemic control (PubMed:37523551, PubMed:39948368). Induces beige adipocyte formation and thermogenesis in response to cold exposure (Ref.5)., [UniProtKB, UniProtKB, PubMed, PubMed]; INHBE functions as a possible hepatokine to alter the whole-body metabolic status under obese insulin-resistant condition Publication Status: Online-Only, [RefSeq, PubMed]; Identification and validation of INHBE and P4HA1 as hub genes in non-alcoholic fatty liver disease., [RefSeq, PubMed]; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins., [UniProtKB]; This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate an inhibin beta subunit. Inhibins have been implicated in regulating numerous cellular processes including cell proliferation, apoptosis, immune response and hormone secretion. This gene may be upregulated under conditions of endoplasmic reticulum stress, and this protein may inhibit cellular proliferation and growth in pancreas and liver. [provided by RefSeq, Sep 2016]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q91XH3", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005179 hormone activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway;GO:0032924 activin receptor signaling pathway;GO:1904178 negative regulation of adipose tissue development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O08717-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O09107-1", "uniprot_id": [ { "id": "INSL3_MOUSE", "url": "https://www.uniprot.org/uniprot/O09107", "type": "external" } ], "mass": 13586.0, "length": 122, "protein_name": "Insulin-like 3", "gene_name": "Insl3", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Insl3; Rlf", "gene_names_refseq": "", "protein_names_uniprotkb": "Insulin-like 3; Ley-I-L; Leydig insulin-like peptide; Relaxin-like factor", "protein_names_refseq": "", "tax_id": 10090, "disease": "cryptorchidism (Disease Ontology:DOID:11383)", "pathway": " (R-MMU-418555); (R-MMU-444821)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10391220;11342953;8770925;9428631", "class_list": "", "function": "Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P97744", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0008285 negative regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O09107-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O89019-1", "uniprot_id": [ { "id": "INVS_MOUSE", "url": "https://www.uniprot.org/uniprot/O89019", "type": "external" } ], "mass": 117129.0, "length": 1062, "protein_name": "Inversin", "gene_name": "Invs", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Invs; Inv; Nphp2", "gene_names_refseq": "", "protein_names_uniprotkb": "Inversin; Inversion of embryo turning protein; Nephrocystin-2", "protein_names_refseq": "", "tax_id": 10090, "disease": "ciliopathy (Disease Ontology:DOID:0060340); nephronophthisis 2 (Disease Ontology:DOID:0111113); hypertension (Disease Ontology:DOID:10763); tetralogy of Fallot (Disease Ontology:DOID:6419)", "pathway": "", "pathway_count": 0, "publication_count": 11, "publication_id_list": "11941489;12221118;12471060;12642479;15533716;21565611;21750661;30084848;34428180;9744276;9771707", "class_list": "", "function": "Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling (By similarity). Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8. Does not seem to be strictly required for ciliogenesis., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O88849", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005819 spindle;GO:0005874 microtubule;GO:0005929 cilium", "go_biological_process": "GO:0060971 embryonic heart tube left/right pattern formation;GO:0006468 protein phosphorylation;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0001822 kidney development;GO:0009791 post-embryonic development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O89019-1", "record_type": "protein", "filter_code": "0000000.0100110.010000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00755-1", "uniprot_id": [ { "id": "K1KB1_MOUSE", "url": "https://www.uniprot.org/uniprot/P00755", "type": "external" } ], "mass": 29022.0, "length": 261, "protein_name": "Kallikrein 1-related peptidase b1", "gene_name": "Klk1b1", "organism": "Mouse", "refseq_name": "kallikrein 1-related peptidase b1 preproprotein", "refseq_ac": [ { "id": "NP_034775", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034775", "type": "external" } ], "gene_names_uniprotkb": "Klk1b1; Klk-1; Klk1", "gene_names_refseq": "Klk1b1; Klk1; mGK-1; mK1", "protein_names_uniprotkb": "Kallikrein 1-related peptidase b1; 3.4.21.35; Glandular kallikrein K1; Tissue kallikrein-1; mGK-1", "protein_names_refseq": "glandular kallikrein K1; kallikrein 1-related peptidase b1 preproprotein", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); hypertension (Disease Ontology:DOID:10763); pancreatitis (Disease Ontology:DOID:4989); myocardial infarction (Disease Ontology:DOID:5844); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (mmu:16623)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "3036794;6602295", "class_list": "", "function": "Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin., [UniProtKB]; This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, Feb 2016]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0030141 secretory granule;GO:0045177 apical part of cell;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0042311 vasodilation;GO:0060048 cardiac muscle contraction;GO:0003073 regulation of systemic arterial blood pressure;GO:0031638 zymogen activation;GO:0002255 tissue kallikrein-kinin cascade", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P00755-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00756-1", "uniprot_id": [ { "id": "K1KB3_MOUSE", "url": "https://www.uniprot.org/uniprot/P00756", "type": "external" } ], "mass": 28998.0, "length": 261, "protein_name": "Kallikrein 1-related peptidase b3", "gene_name": "Klk1b3", "organism": "Mouse", "refseq_name": "kallikrein 1-related peptidase b3 preproprotein", "refseq_ac": [ { "id": "NP_032719", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032719", "type": "external" } ], "gene_names_uniprotkb": "Klk1b3; Klk-3; Klk3; Ngfg", "gene_names_refseq": "Klk1b3; Ngfg; gamma-NGF; mGk-3", "protein_names_uniprotkb": "Kallikrein 1-related peptidase b3; 3.4.21.35; 7S nerve growth factor gamma chain; Gamma-NGF; Glandular kallikrein K3; Tissue kallikrein-3; mGK-3", "protein_names_refseq": "7S nerve growth factor gamma chain; 7S nerve growth factor gamma subunit; glandular kallikrein K3; kallikrein 1-related peptidase b3 preproprotein; tissue kallikrein-3", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); hypertension (Disease Ontology:DOID:10763); pancreatitis (Disease Ontology:DOID:4989); myocardial infarction (Disease Ontology:DOID:5844); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (mmu:18050)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "3848399;6548955;7263706;9351801", "class_list": "", "function": "7S NGF alpha chain stabilizes the 7S complex. The beta dimer promotes neurite growth. The gamma chain is an arginine-specific protease; it may also have plasminogen activator activity, as well as mitogenic activity for chick embryo fibroblasts., [UniProtKB]; This gene encodes the gamma subunit of the 7S nerve growth factor (NGF) complex that is essential for the differentiation and survival of distinct populations of neurons in both the central and the peripheral nervous systems. The encoded protein is a glandular kallikrein-type serine protease that processes the beta subunit of NGF. This gene is present in a cluster of multiple related kallikrein-type protease genes on chromosome 7. [provided by RefSeq, Jul 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2RTW1", "ec_number_list": [], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0046872 metal ion binding;GO:0008083 growth factor activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0030141 secretory granule;GO:0045177 apical part of cell;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0003073 regulation of systemic arterial blood pressure;GO:0031638 zymogen activation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P00756-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00757-1", "uniprot_id": [ { "id": "K1KB4_MOUSE", "url": "https://www.uniprot.org/uniprot/P00757", "type": "external" } ], "mass": 28548.0, "length": 256, "protein_name": "Kallikrein 1-related peptidase-like b4", "gene_name": "Klk1b4", "organism": "Mouse", "refseq_name": "kallikrein 1-related peptidase-like b4 precursor", "refseq_ac": [ { "id": "NP_035045", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035045", "type": "external" } ], "gene_names_uniprotkb": "Klk1b4; Klk-4; Klk4; Ngfa", "gene_names_refseq": "Klk1b4; Ngfa; alpha-NGF; mGk-4", "protein_names_uniprotkb": "Kallikrein 1-related peptidase-like b4; 7S nerve growth factor alpha chain; Alpha-NGF", "protein_names_refseq": "7S nerve growth factor alpha chain; 7S nerve growth factor alpha subunit; kallikrein 1-related peptidase-like b4 precursor; kallikrein 1-related peptidase-like b4", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); hypertension (Disease Ontology:DOID:10763); pancreatitis (Disease Ontology:DOID:4989); myocardial infarction (Disease Ontology:DOID:5844); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (mmu:18048)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "16315017;16967509;17980967;3848399;6395888;6712944;9351801", "class_list": "", "function": "Exposure to music in mice can influence neurotrophin production in the hypothalamus. Physiological effects of music might be in part mediated by modulation of neurotrophins., [RefSeq, PubMed]; The results suggest that the decreased availability of NGF after axotomy is a sufficient stimulus to induce the conditioning lesion effect in sympathetic neurons., [RefSeq, PubMed]; This gene encodes the alpha subunit of the 7S nerve growth factor (NGF) complex that is essential for the differentiation and survival of distinct populations of neurons in both the central and the peripheral nervous systems. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, Feb 2016]., [RefSeq]; We demonstrate that overexpression of nerve growth factor (NGF) in brown adipose tissue (BAT) of NGF-transgenic mice elevates both mRNA and protein levels of vascular endothelial growth factor (VEGF) and VEGF-receptors., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0046872 metal ion binding;GO:0008083 growth factor activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0030141 secretory granule;GO:0045177 apical part of cell;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0007264 small GTPase-mediated signal transduction;GO:0003073 regulation of systemic arterial blood pressure;GO:0031638 zymogen activation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P00757-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01325-1", "uniprot_id": [ { "id": "INS1_MOUSE", "url": "https://www.uniprot.org/uniprot/P01325", "type": "external" } ], "mass": 12160.0, "length": 108, "protein_name": "Insulin-1", "gene_name": "Ins1", "organism": "Mouse", "refseq_name": "insulin-1 preproprotein", "refseq_ac": [ { "id": "NP_032412", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032412", "type": "external" } ], "gene_names_uniprotkb": "Ins1; Ins-1", "gene_names_refseq": "Ins-1; Ins1; Ins2-rs1", "protein_names_uniprotkb": "Insulin-1", "protein_names_refseq": "insulin-1 preproprotein; insulin-1", "tax_id": 10090, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); permanent neonatal diabetes mellitus (Disease Ontology:DOID:0060639); type 1 diabetes mellitus 2 (Disease Ontology:DOID:0110741); maturity-onset diabetes of the young type 10 (Disease Ontology:DOID:0111108); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); gestational diabetes (Disease Ontology:DOID:11714); pancreatic cancer (Disease Ontology:DOID:1793); hyperuricemia (Disease Ontology:DOID:1920); hyperinsulinism (Disease Ontology:DOID:2018); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); insulinoma (Disease Ontology:DOID:3892); cholangiocarcinoma (Disease Ontology:DOID:4947); osteoarthritis (Disease Ontology:DOID:8398); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:16333); (R-MMU-264876); (R-MMU-422085); (R-MMU-6807878); (R-MMU-6811558); (R-MMU-74713); (R-MMU-74749); (R-MMU-74751); (R-MMU-74752); (R-MMU-77387)", "pathway_count": 10, "publication_count": 19, "publication_id_list": "12193712;15843527;16682971;17459508;17620420;18157812;19208910;19966211;20381385;21346176;22194932;22539795;2397023;28665492;29955175;3104603;32152506;34203471;5063718", "class_list": "", "function": "Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver., [UniProtKB]; This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. The encoded precursor protein undergoes proteolytic cleavage to produce a disulfide-linked heterodimeric functional protein that is stored in secretory granules. An increase in blood glucose levels, among others, induces the release of insulin from the secretory granules. Mice deficient in the functional hormone encoded by this gene develop diabetes mellitus. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q545I7;Q9D907", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0005158 insulin receptor binding;GO:0042802 identical protein binding;GO:0005159 insulin-like growth factor receptor binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005788 endoplasmic reticulum lumen;GO:0005829 cytosol;GO:0031012 extracellular matrix", "go_biological_process": "GO:1903427 negative regulation of reactive oxygen species biosynthetic process;GO:0050709 negative regulation of protein secretion;GO:1904659 D-glucose transmembrane transport;GO:0045818 negative regulation of glycogen catabolic process;GO:0045922 negative regulation of fatty acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P01325-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07628-1", "uniprot_id": [ { "id": "K1KB8_MOUSE", "url": "https://www.uniprot.org/uniprot/P07628", "type": "external" } ], "mass": 28531.0, "length": 261, "protein_name": "Kallikrein 1-related peptidase b8", "gene_name": "Klk1b8", "organism": "Mouse", "refseq_name": "kallikrein 1-related peptidase b8 preproprotein", "refseq_ac": [ { "id": "NP_032483", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032483", "type": "external" } ], "gene_names_uniprotkb": "Klk1b8; Klk-8; Klk8", "gene_names_refseq": "Klk1b8; Klk8; Nrpn; TADG14; kallikrein; mGK-8", "protein_names_uniprotkb": "Kallikrein 1-related peptidase b8; 3.4.21.35; Glandular kallikrein K8; Tissue kallikrein-8; mGK-8", "protein_names_refseq": "glandular kallikrein K8; kallikrein 1-related peptidase b8 preproprotein; pseudo-kallikrein; tissue kallikrein-8", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); hypertension (Disease Ontology:DOID:10763); pancreatitis (Disease Ontology:DOID:4989); myocardial infarction (Disease Ontology:DOID:5844); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (mmu:16624)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;3036794;3636812", "class_list": "", "function": "Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin., [UniProtKB]; This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, Feb 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0030141 secretory granule;GO:0045177 apical part of cell;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0003073 regulation of systemic arterial blood pressure;GO:0031638 zymogen activation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P07628-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08730-1", "uniprot_id": [ { "id": "K1C13_MOUSE", "url": "https://www.uniprot.org/uniprot/P08730", "type": "external" } ], "mass": 47754.0, "length": 437, "protein_name": "Keratin, type I cytoskeletal 13", "gene_name": "Krt13", "organism": "Mouse", "refseq_name": "keratin, type I cytoskeletal 13 isoform 2", "refseq_ac": [ { "id": "NP_001300878", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001300878", "type": "external" } ], "gene_names_uniprotkb": "Krt13; Krt1-13", "gene_names_refseq": "CK13; K13; Krt-1.13; Krt1-13; Krt13", "protein_names_uniprotkb": "Keratin, type I cytoskeletal 13; 47 kDa cytokeratin; CK-13; Cytokeratin-13; K13; Keratin-13", "protein_names_refseq": "47 kDa cytokeratin; CK-13; cytokeratin 13; keratin complex 1, acidic, gene 13; keratin, type I cytoskeletal 13 isoform 2; keratin, type I cytoskeletal 13", "tax_id": 10090, "disease": "white sponge nevus (Disease Ontology:DOID:0050448); white sponge nevus 2 (Disease Ontology:DOID:0081288)", "pathway": " (mmu:16663); (R-MMU-6805567); (R-MMU-6809371)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "1695590;2418416;26758872;32152506;32758484;34019948;34428180;36583994;7535287", "class_list": "", "function": "Structural component of intermediate filaments in mucosal stratified squamous epithelia. Forms heteropolymers with the type II keratin KRT4, assembling into keratin intermediate filament networks that provides structural integrity and mechanical stability of the mucosal epithelium (By similarity). Contributes to postnatal tongue mucosal cell homeostasis and tissue organization in response to mechanical stress, potentially through regulation of the G1/S phase cyclins CCNE1 and CCNE2 (PubMed:32758484)., [UniProtKB, UniProtKB, PubMed]; The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V176;Q6PAI1", "ec_number_list": [], "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0070062 extracellular exosome;GO:0045111 intermediate filament cytoskeleton;GO:0045095 keratin filament", "go_biological_process": "GO:0043555 regulation of translation in response to stress;GO:0030855 epithelial cell differentiation;GO:0071300 cellular response to retinoic acid;GO:0007010 cytoskeleton organization;GO:0045109 intermediate filament organization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P08730-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15945-1", "uniprot_id": [ { "id": "K1KB5_MOUSE", "url": "https://www.uniprot.org/uniprot/P15945", "type": "external" } ], "mass": 28748.0, "length": 261, "protein_name": "Kallikrein 1-related peptidase b5", "gene_name": "Klk1b5", "organism": "Mouse", "refseq_name": "kallikrein 1-related peptidase b5 preproprotein", "refseq_ac": [ { "id": "NP_032482", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032482", "type": "external" } ], "gene_names_uniprotkb": "Klk1b5; Klk-5; Klk5", "gene_names_refseq": "Klk1b5; Klk5; kallikrein; mGK-5", "protein_names_uniprotkb": "Kallikrein 1-related peptidase b5; 3.4.21.35; Glandular kallikrein K5; Tissue kallikrein-5; mGK-5", "protein_names_refseq": "glandular kallikrein K5; kallikrein 1-related peptidase b5 preproprotein; tissue kallikrein-5", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); hypertension (Disease Ontology:DOID:10763); breast cancer (Disease Ontology:DOID:1612); pancreatitis (Disease Ontology:DOID:4989); myocardial infarction (Disease Ontology:DOID:5844); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (mmu:16622)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "22202692;3036794;30957940;3502721", "class_list": "", "function": "Data support a completely novel mechanism in which miR-382 targets kallikrein 5 and contributes to the development of renal inner medullary interstitial fibrosis., [RefSeq, PubMed]; Deletion of kallikrein 1b5 (Klk1b5) has no impact on fertility in mice., [RefSeq, PubMed]; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin., [UniProtKB]; This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, Feb 2016]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q52KM1;Q565D7", "ec_number_list": [], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0030141 secretory granule;GO:0045177 apical part of cell;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0006508 proteolysis;GO:0003073 regulation of systemic arterial blood pressure;GO:0031638 zymogen activation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P15945-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15949-1", "uniprot_id": [ { "id": "K1KB9_MOUSE", "url": "https://www.uniprot.org/uniprot/P15949", "type": "external" } ], "mass": 28900.0, "length": 261, "protein_name": "Kallikrein 1-related peptidase b9", "gene_name": "Klk1b9", "organism": "Mouse", "refseq_name": "kallikrein 1-related peptidase b9 preproprotein", "refseq_ac": [ { "id": "NP_034246", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034246", "type": "external" } ], "gene_names_uniprotkb": "Klk1b9; Egfbp3; Klk-9; Klk9", "gene_names_refseq": "EGF-BP C; Egfbp-3; Egfbp3; KAL; Klk1b9; Klk9; kallikrein; mGk-9", "protein_names_uniprotkb": "Kallikrein 1-related peptidase b9; 3.4.21.35; EGF-BP C; Epidermal growth factor-binding protein type C; Glandular kallikrein K9; Tissue kallikrein-9; mGK-9", "protein_names_refseq": "epidermal growth factor-binding protein type C; glandular kallikrein K9; kallikrein 1-related peptidase b9 preproprotein; tissue kallikrein-9", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); hypertension (Disease Ontology:DOID:10763); pancreatitis (Disease Ontology:DOID:4989); myocardial infarction (Disease Ontology:DOID:5844); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (mmu:13648)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "3036794;3322386;3322387", "class_list": "", "function": "Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin., [UniProtKB]; This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, Feb 2016]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0008233 peptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0030141 secretory granule;GO:0045177 apical part of cell;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0003073 regulation of systemic arterial blood pressure;GO:0031638 zymogen activation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P15949-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55104-1", "uniprot_id": [ { "id": "INHBC_MOUSE", "url": "https://www.uniprot.org/uniprot/P55104", "type": "external" } ], "mass": 39401.0, "length": 352, "protein_name": "Inhibin beta C chain", "gene_name": "Inhbc", "organism": "Mouse", "refseq_name": "inhibin beta C chain preproprotein", "refseq_ac": [ { "id": "NP_034695", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034695", "type": "external" } ], "gene_names_uniprotkb": "Inhbc", "gene_names_refseq": "Inhbc", "protein_names_uniprotkb": "Inhibin beta C chain; Activin beta-C chain", "protein_names_refseq": "activin beta-C chain; inhibin beta C chain preproprotein; inhibin beta C chain", "tax_id": 10090, "disease": "", "pathway": " (mmu:16325); (R-MMU-209822)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "25869398;28363632;8679697;8838799;9070865", "class_list": "", "function": "Data reinforces the importance of activin-betaC in reproductive biology and suggests that activin-betaC is a tumor modulator with gonadal specificity., [RefSeq, PubMed]; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins., [UniProtKB]; Results showed activin-C and follistatin are differentially expressed during prostate development and suggested that the antagonistic property of follistatin is secondary to the action of activin-C. Study provides evidence to support a role of activin-C in prostate development and provides new insights in the spatiotemporal localization of activins and their antagonists during mouse prostate development., [RefSeq, PubMed]; This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of homodimeric and heterodimeric activin complexes. The heterodimeric complex may function in the inhibition of activin A signaling. Transgenic mice overexpressing this gene exhibit defects in testis, liver and prostate. [provided by RefSeq, Aug 2016]., [RefSeq]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q61452", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005179 hormone activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P55104-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P59053-1", "uniprot_id": [ { "id": "KCNG3_MOUSE", "url": "https://www.uniprot.org/uniprot/P59053", "type": "external" } ], "mass": 49247.0, "length": 433, "protein_name": "Voltage-gated potassium channel regulatory subunit KCNG3", "gene_name": "Kcng3", "organism": "Mouse", "refseq_name": "voltage-gated potassium channel regulatory subunit KCNG3", "refseq_ac": [ { "id": "NP_705732", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_705732", "type": "external" } ], "gene_names_uniprotkb": "Kcng3", "gene_names_refseq": "KV6.3; Kcng3; Kv10.1a; Kv10.1b", "protein_names_uniprotkb": "Voltage-gated potassium channel regulatory subunit KCNG3; Potassium voltage-gated channel subfamily G member 3; Voltage-gated potassium channel subunit Kv10.1; Voltage-gated potassium channel subunit Kv6.3", "protein_names_refseq": "voltage-gated potassium channel regulatory subunit KCNG3; voltage-gated potassium channel subunit Kv10.1; voltage-gated potassium channel subunit Kv6.3", "tax_id": 10090, "disease": "", "pathway": " (mmu:225030); (R-MMU-1296072)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulatory subunit of the voltage-gated potassium (Kv) channel which, when coassembled with KCNB1, modulates the kinetics parameters of the heterotetrameric channel namely the inactivation and deactivation rate. Potassium channel subunit that does not form functional channels by itself. Reduces the deactivation rate. Moderately acceleratee activation., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0051260 protein homooligomerization;GO:0001508 action potential;GO:0043266 regulation of potassium ion transport;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P59053-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70458-1", "uniprot_id": [ { "id": "IPSP_MOUSE", "url": "https://www.uniprot.org/uniprot/P70458", "type": "external" } ], "mass": 45600.0, "length": 405, "protein_name": "Plasma serine protease inhibitor", "gene_name": "Serpina5", "organism": "Mouse", "refseq_name": "plasma serine protease inhibitor precursor", "refseq_ac": [ { "id": "NP_766541", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766541", "type": "external" } ], "gene_names_uniprotkb": "Serpina5; Pci", "gene_names_refseq": "4933415L04; PAI-3; Pci; Serpina5", "protein_names_uniprotkb": "Plasma serine protease inhibitor; PAI-3; PAI3; PCI; Plasminogen activator inhibitor 3; Protein C inhibitor; Serpin A5", "protein_names_refseq": "PAI3; alpha-1 antiproteinase; antitrypsin; plasma serine protease inhibitor precursor; plasma serine protease inhibitor; plasminogen activator inhibitor-3; protein C inhibitor; serine (or cysteine) proteinase inhibitor, clade A, member 5; serpin A5", "tax_id": 10090, "disease": "", "pathway": " (mmu:268591); (R-MMU-9769733); (R-MMU-9769739); (R-MMU-9769743)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "11120760;15140131;25000564;31219806;35194761;9047345", "class_list": "", "function": "Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation site. Involved in the regulation of intravascular and extravascular proteolytic activities. Plays hemostatic roles in the blood plasma. Acts as a procoagulant and pro-inflammatory factor by inhibiting the anticoagulant activated protein C factor as well as the generation of activated protein C factor by the thrombin/thrombomodulin complex. Acts as an anticoagulant factor by inhibiting blood coagulation factors like prothrombin, factor XI, factor Xa, plasma kallikrein and fibrinolytic enzymes such as tissue- and urinary-type plasminogen activators. In seminal plasma, inactivates several serine proteases implicated in the reproductive system. Inhibits the serpin acrosin; indirectly protects component of the male genital tract from being degraded by excessive released acrosin. Inhibits tissue- and urinary-type plasminogen activator, prostate-specific antigen and kallikrein activities; has a control on the sperm motility and fertilization. Inhibits the activated protein C-catalyzed degradation of SEMG1 and SEMG2; regulates the degradation of semenogelin during the process of transfer of spermatozoa from the male reproductive tract into the female tract. In urine, inhibits urinary-type plasminogen activator and kallikrein activities. Inactivates membrane-anchored serine proteases activities such as MPRSS7 and TMPRSS11E. Inhibits urinary-type plasminogen activator-dependent tumor cell invasion and metastasis. May also play a non-inhibitory role in seminal plasma and urine as a hydrophobic hormone carrier by its binding to retinoic acid (By similarity)., [UniProtKB]; Role of PCI not only for the function and/or maturation of macrophages, but also as a negative regulator of apoptotic cell and activated platelets removal Publication Status: Online-Only, [RefSeq, PubMed]; SERPINA5 Protein in Cumulus-Oocyte Complexes Increases the Fertilisation Ability of Mouse Sperm., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5BKQ8;Q8BU50", "ec_number_list": [], "go_molecular_function": "GO:0032190 acrosin binding;GO:0002020 protease binding;GO:0004867 serine-type endopeptidase inhibitor activity;GO:0031210 phosphatidylcholine binding;GO:0001972 retinoic acid binding", "go_cellular_component": "GO:0031094 platelet dense tubular network;GO:0036024 protein C inhibitor-TMPRSS7 complex;GO:0036025 protein C inhibitor-TMPRSS11E complex;GO:0036026 protein C inhibitor-PLAT complex;GO:0036027 protein C inhibitor-PLAU complex", "go_biological_process": "GO:0007283 spermatogenesis;GO:0045861 negative regulation of proteolysis;GO:0070684 seminal clot liquefaction", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P70458-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97825-1", "uniprot_id": [ { "id": "JUPI1_MOUSE", "url": "https://www.uniprot.org/uniprot/P97825", "type": "external" } ], "mass": 16081.0, "length": 154, "protein_name": "Jupiter microtubule associated homolog 1", "gene_name": "Jpt1", "organism": "Mouse", "refseq_name": "jupiter microtubule associated homolog 1", "refseq_ac": [ { "id": "NP_032284", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032284", "type": "external" } ], "gene_names_uniprotkb": "Jpt1; Hn1", "gene_names_refseq": "Hn1; Jpt1", "protein_names_uniprotkb": "Jupiter microtubule associated homolog 1; Hematological and neurological expressed 1 protein", "protein_names_refseq": "hematological and neurological expressed 1 protein; hematological and neurological expressed sequence 1; jupiter microtubule associated homolog 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:15374)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;17242355;19144319;19145478;19427096;21183079;23806337;25450365;26495903;28011936;31219806;32069316;35820727;37828378;9271675", "class_list": "", "function": "Hn1 depletion in B16.F10 melanoma cells promotes a differentiated phenotype that includes increased melanogenesis and cell cycle arrest., [RefSeq, PubMed]; Modulates negatively AKT-mediated GSK3B signaling. Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions (By similarity). Plays a role in the regulation of cell cycle and cell adhesion (PubMed:25450365). Has an inhibitory role on AR-signaling pathway through the induction of receptor proteasomal degradation (By similarity)., [UniProtKB, UniProtKB, PubMed]; These data suggest a role for Hn1 in the biology of malignant brain tumors., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0015630 microtubule cytoskeleton;GO:0045171 intercellular bridge", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P97825-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q04999-1", "uniprot_id": [ { "id": "INHBB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q04999", "type": "external" } ], "mass": 45211.0, "length": 411, "protein_name": "Inhibin beta B chain", "gene_name": "Inhbb", "organism": "Mouse", "refseq_name": "inhibin beta B chain preproprotein", "refseq_ac": [ { "id": "NP_032407", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032407", "type": "external" } ], "gene_names_uniprotkb": "Inhbb", "gene_names_refseq": "Inhbb", "protein_names_uniprotkb": "Inhibin beta B chain; Activin beta-B chain", "protein_names_refseq": "activin beta-B chain; inhibin beta B chain preproprotein; inhibin beta B chain", "tax_id": 10090, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328)", "pathway": " (mmu:16324); (R-MMU-1502540); (R-MMU-209822); (R-MMU-2473224)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;18480258;20382119;25428506;28396222;35690801;7619733;8125256;8330535", "class_list": "", "function": "Activin B is a dimer of alpha and beta-B that plays a role in several essential biological processes including embryonic development, stem cell maintenance and differentiation, haematopoiesis, cell proliferation and wound healing (PubMed:8125256). Signals through type I receptor ACVR1C, abundantly expressed in pancreatic beta cells, and type II receptors like ACVR2A. Upon ligand binding, these receptors phosphorylate intracellular signaling mediators SMAD2 and SMAD3, which form a complex with SMAD4, translocate to the nucleus, and regulate gene expression. Plays a crucial role in the induction of hepcidin by inflammation through activation of ACVR1C and subsequent phosphorylation of SMAD1/5/8 (PubMed:18480258). Regulates adipocyte lipid metabolism by decreasing non-esterified fatty acids and glycerol release and increases intracellular triglyceride content (PubMed:20382119). Stimulates wound healing by promoting cell migration and hair follicle regeneration through the JNK and ERK signaling pathways downstream of RHOA (PubMed:28396222, PubMed:35690801)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Inhibin B is a dimer of alpha and beta-B that plays a crucial role in the regulation of the reproductive system by inhibiting the secretion of follicle-stimulating hormone (FSH) from the anterior pituitary gland. Thereby, maintains reproductive homeostasis in both males and females. Acts as a more potent suppressor of FSH release than inhibin A (By similarity). Functions as competitive receptor antagonist binding activin type II receptors with high affinity in the presence of the TGF-beta type III coreceptor/TGFBR3L (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins., [UniProtKB, UniProtKB]; This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. Homozygous knockout mice for this gene exhibit eyelid defects. [provided by RefSeq, Aug 2016]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3V1N0;Q61277;Q80VC4", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0005125 cytokine activity;GO:0005179 hormone activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0048471 perinuclear region of cytoplasm;GO:0071944 cell periphery", "go_biological_process": "GO:0046882 negative regulation of follicle-stimulating hormone secretion;GO:0060279 positive regulation of ovulation;GO:0007283 spermatogenesis;GO:0032869 cellular response to insulin stimulus;GO:0071320 cellular response to cAMP", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q04999-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000001000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VBK2-1", "uniprot_id": [ { "id": "K2C80_MOUSE", "url": "https://www.uniprot.org/uniprot/Q0VBK2", "type": "external" } ], "mass": 50660.0, "length": 452, "protein_name": "Keratin, type II cytoskeletal 80", "gene_name": "Krt80", "organism": "Mouse", "refseq_name": "keratin, type II cytoskeletal 80", "refseq_ac": [ { "id": "NP_083046", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083046", "type": "external" } ], "gene_names_uniprotkb": "Krt80; Kb20", "gene_names_refseq": "1200016G03Rik; 2310041I20Rik; CK-80; K80; Kb20; Krt80", "protein_names_uniprotkb": "Keratin, type II cytoskeletal 80; CK-80; Cytokeratin-80; K80; Keratin-80; Type-II keratin Kb20", "protein_names_refseq": "cytokeratin-80; keratin, type II cytoskeletal 80; type-II keratin Kb20", "tax_id": 10090, "disease": "", "pathway": " (mmu:74127); (R-MMU-6805567); (R-MMU-6809371)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "21750661;36583994;39627609", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005882 intermediate filament;GO:0045111 intermediate filament cytoskeleton;GO:0045095 keratin filament", "go_biological_process": "GO:0031424 keratinization;GO:0045109 intermediate filament organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q0VBK2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32M07-1", "uniprot_id": [ { "id": "KAD8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q32M07", "type": "external" } ], "mass": 55073.0, "length": 479, "protein_name": "Adenylate kinase 8", "gene_name": "Ak8", "organism": "Mouse", "refseq_name": "adenylate kinase 8", "refseq_ac": [ { "id": "NP_001029046", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029046", "type": "external" } ], "gene_names_uniprotkb": "Ak8", "gene_names_refseq": "1190002A17Rik; AK 8; Ak8", "protein_names_uniprotkb": "Adenylate kinase 8; 2.7.4.3; 2.7.4.6; AK 8; ATP-AMP transphosphorylase 8", "protein_names_refseq": "ATP-AMP transphosphorylase 8; Adenylate kinase isoenzyme 4, mitochondrial (ATP-AMP transphosphorylase); adenylate kinase 8; putative adenylate kinase-like protein C9orf98 homolog", "tax_id": 10090, "disease": "hydrocephalus (Disease Ontology:DOID:10908)", "pathway": " (mmu:68870); (R-MMU-499943)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21746835;24740601", "class_list": "", "function": "Congenital hydrocephalus and rhinosinusitis in Ak8 null mice, [RefSeq, PubMed]; In addition to AK1 and AK2, which we previously demonstrated are present in outer dense fibers and mitochondrial sheath of the mouse sperm tail, we show that another AK, AK8, is present in a third flagellar compartment, the axoneme., [RefSeq, PubMed]; Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q497L2", "ec_number_list": [ { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.4", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.7.4.14", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.14", "type": "external" } ], "go_molecular_function": "GO:0004017 AMP kinase activity;GO:0005524 ATP binding;GO:0016208 AMP binding;GO:0004550 nucleoside diphosphate kinase activity;GO:0036431 dCMP kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0036126 sperm flagellum;GO:0005930 axoneme", "go_biological_process": "GO:0021591 ventricular system development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q32M07-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TRJ4-1", "uniprot_id": [ { "id": "K1C26_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TRJ4", "type": "external" } ], "mass": 51118.0, "length": 462, "protein_name": "Keratin, type I cytoskeletal 26", "gene_name": "Krt26", "organism": "Mouse", "refseq_name": "keratin, type I cytoskeletal 26", "refseq_ac": [ { "id": "NP_001028569", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028569", "type": "external" } ], "gene_names_uniprotkb": "Krt26", "gene_names_refseq": "4732407F15Rik; Krt25b; Krt26", "protein_names_uniprotkb": "Keratin, type I cytoskeletal 26; CK-26; Cytokeratin-26; K26; Keratin-26; Type I inner root sheath-specific keratin-K25irs2", "protein_names_refseq": "CK-26; K26; cytokeratin-26; keratin 25B; keratin, type I cytoskeletal 26; type I inner root sheath-specific keratin-K25irs2", "tax_id": 10090, "disease": "", "pathway": " (mmu:320864); (R-MMU-6805567); (R-MMU-6809371)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "39627609", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V1H8", "ec_number_list": [], "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0045095 keratin filament", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0045109 intermediate filament organization;GO:0002009 morphogenesis of an epithelium", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3TRJ4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U492-1", "uniprot_id": [ { "id": "KCP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U492", "type": "external" } ], "mass": 166628.0, "length": 1550, "protein_name": "Kielin/chordin-like protein", "gene_name": "Kcp", "organism": "Mouse", "refseq_name": "kielin/chordin-like protein precursor", "refseq_ac": [ { "id": "NP_001025156", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025156", "type": "external" } ], "gene_names_uniprotkb": "Kcp; Crim2; Kcp1", "gene_names_refseq": "CRIM-2; Crim2; Gm793; KCP-1; Kcp", "protein_names_uniprotkb": "Kielin/chordin-like protein; CRIM-2; Cysteine-rich BMP regulator 2; Cysteine-rich motor neuron 2 protein; KCP-1; Kielin/chordin-like protein 1", "protein_names_refseq": "cysteine rich BMP regulator 2 (chordin like); cysteine-rich BMP regulator 2; cysteine-rich motor neuron 2 protein; kielin/chordin-like protein 1; kielin/chordin-like protein precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:333088)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15793581;16738323;21750661;23539757;25428506;28424263;37149518;38421300", "class_list": "", "function": "Enhances bone morphogenetic protein (BMP) signaling in a paracrine manner. In contrast, it inhibits both the activin-A and TGFB1-mediated signaling pathways., [UniProtKB, PubMed]; Kielin/chordin-like protein deficiency aggravates pressure overload-induced cardiac dysfunction and remodeling via P53/P21/CCNB1 signaling in mice., [RefSeq, PubMed]; Kielin/chordin-like protein deficiency causes cardiac aging in male mice., [RefSeq, PubMed]; Metabolic profiling indicated increased energy expenditure in KCP-overexpressing mice and reduced expenditure in the KCP mutants with no effect on food intake or activity. These findings demonstrate that shifting the TGF-beta superfamily signaling with a secreted protein can alter the physiology and thermogenic properties of adipose tissue to reduce obesity even when mice are fed a high-fat diet., [RefSeq, PubMed]; Role for KCP in modulating the responses between these anti- and profibrotic cytokines in the initiation and progression of renal interstitial fibrosis, [RefSeq, PubMed]; The data indicate an important role for KCP in attenuating the pathology of renal fibrotic disease., [RefSeq, PubMed]; These data suggest that extracellular regulation of the TGF-beta/BMP signaling axis by KCP, and by extension possibly other cysteine-rich domain proteins, can attenuate both acute and chronic renal injury., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QJU0;Q56NI8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0030513 positive regulation of BMP signaling pathway;GO:0002244 hematopoietic progenitor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q3U492-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UQV5-1", "uniprot_id": [ { "id": "KBTB8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UQV5", "type": "external" } ], "mass": 68660.0, "length": 599, "protein_name": "Kelch repeat and BTB domain-containing protein 8", "gene_name": "Kbtbd8", "organism": "Mouse", "refseq_name": "kelch repeat and BTB domain-containing protein 8 isoform a", "refseq_ac": [ { "id": "NP_001008785", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008785", "type": "external" } ], "gene_names_uniprotkb": "Kbtbd8; Kiaa1842", "gene_names_refseq": "Kbtbd8; SSEC-51; SSEC51; Takrp; mKIAA1842", "protein_names_uniprotkb": "Kelch repeat and BTB domain-containing protein 8", "protein_names_refseq": "SSEC 51; T-cell activation kelch repeat protein; kelch repeat and BTB domain-containing protein 8 isoform a; kelch repeat and BTB domain-containing protein 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:243574); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "21750661;26399832;31219806", "class_list": "", "function": "Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJB2;Q5M7B2;Q8CH97", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005819 spindle;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0014029 neural crest formation;GO:0006417 regulation of translation;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0014032 neural crest cell development;GO:0006513 protein monoubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3UQV5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UV16-1", "uniprot_id": [ { "id": "IPIL2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UV16", "type": "external" } ], "mass": 58665.0, "length": 535, "protein_name": "Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2", "gene_name": "Itpripl2", "organism": "Mouse", "refseq_name": "inositol 1,4,5-trisphosphate receptor-interacting protein-like 2 precursor", "refseq_ac": [ { "id": "NP_001028552", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028552", "type": "external" } ], "gene_names_uniprotkb": "Itpripl2", "gene_names_refseq": "C130081G24; E030018N11Rik; Itpripl2", "protein_names_uniprotkb": "Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2", "protein_names_refseq": "inositol 1,4,5-trisphosphate receptor-interacting protein-like 2 precursor; inositol 1,4,5-trisphosphate receptor-interacting protein-like 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:319622)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "26740625", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RX24;Q3UE60", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3UV16-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UV17-1", "uniprot_id": [ { "id": "K22O_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UV17", "type": "external" } ], "mass": 62845.0, "length": 594, "protein_name": "Keratin, type II cytoskeletal 2 oral", "gene_name": "Krt76", "organism": "Mouse", "refseq_name": "keratin, type II cytoskeletal 2 oral", "refseq_ac": [ { "id": "NP_001028349", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028349", "type": "external" } ], "gene_names_uniprotkb": "Krt76", "gene_names_refseq": "2310001L23Rik; K76; Krt76", "protein_names_uniprotkb": "Keratin, type II cytoskeletal 2 oral; K76; Keratin-76; Type-II keratin Kb9", "protein_names_refseq": "keratin, type II cytoskeletal 2 oral; type-II keratin Kb9", "tax_id": 10090, "disease": "", "pathway": " (mmu:77055); (R-MMU-6805567); (R-MMU-6809371)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "25340345;30143634;31219806;33300544;34428180;34887587;35820727;36064721;36288343;36583994;37935063;39627609;41018975", "class_list": "", "function": "Data shows that immunomodulatory role of Keratin 76 in oral and gastric cancer. Publication Status: Online-Only, [RefSeq, PubMed]; K2P2.1 is a regulator of inflammatory cell responses in idiopathic inflammatory myopathies., [RefSeq, PubMed]; Probably contributes to terminal cornification., [UniProtKB, UniProtKB]; We further demonstrate that KRT76 interacts with CLDN1 and propose that this interaction is necessary to correctly position CLDN1 in tight junctions. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0045095 keratin filament", "go_biological_process": "GO:0048733 sebaceous gland development;GO:0031424 keratinization;GO:0008544 epidermis development;GO:0045109 intermediate filament organization;GO:0043473 pigmentation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q3UV17-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UZV7-1", "uniprot_id": [ { "id": "ELAP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UZV7", "type": "external" } ], "mass": 113660.0, "length": 1028, "protein_name": "Endosome/lysosome-associated apoptosis and autophagy regulator family member 2", "gene_name": "Elapor2", "organism": "Mouse", "refseq_name": "endosome/lysosome-associated apoptosis and autophagy regulator family member 2 isoform 1 precursor", "refseq_ac": [ { "id": "NP_766294", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766294", "type": "external" } ], "gene_names_uniprotkb": "Elapor2; 9330182L06Rik; Eig121l", "gene_names_refseq": "9330182L06Rik; Eig121l; Elapor2", "protein_names_uniprotkb": "Endosome/lysosome-associated apoptosis and autophagy regulator family member 2; Estrogen-induced gene 121-like protein", "protein_names_refseq": "UPF0577 protein KIAA1324-like homolog; endosome/lysosome-associated apoptosis and autophagy regulator family member 2 isoform 1 precursor; estrogen-induced gene 121-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:231014)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;21177533;21750661;30899004;40885482", "class_list": "", "function": "Functions as a regulator of the BMP signaling pathway and may be involved in epidermal differentiation., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 12, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q8BJM9;Q8BJN9;Q8BJT7;Q8BKX9;Q8BL89;Q8BLT1;Q8BM91", "ec_number_list": [], "go_molecular_function": "GO:0070700 BMP receptor binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0030513 positive regulation of BMP signaling pathway;GO:0045684 positive regulation of epidermis development;GO:0051961 negative regulation of nervous system development", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q3UZV7-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61765-1", "uniprot_id": [ { "id": "K1H1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61765", "type": "external" } ], "mass": 47117.0, "length": 416, "protein_name": "Keratin, type I cuticular Ha1", "gene_name": "Krt31", "organism": "Mouse", "refseq_name": "keratin, type I cuticular Ha1", "refseq_ac": [ { "id": "NP_034789", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034789", "type": "external" } ], "gene_names_uniprotkb": "Krt31; Hka1; Krt1-1; Krtha1", "gene_names_refseq": "Ha1; Kha1; Krt1-1; Krt31; MKHA-1", "protein_names_uniprotkb": "Keratin, type I cuticular Ha1; HKA-1; Hair keratin, type I Ha1; K31; Keratin-31", "protein_names_refseq": "HKA-1; K31; hair keratin, type I Ha1; keratin complex 1, acidic, gene 1; keratin complex 1, gene 1; keratin, type I cuticular Ha1", "tax_id": 10090, "disease": "", "pathway": " (mmu:16660); (R-MMU-6805567); (R-MMU-6809371)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "23817565;2461417;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A5Y0", "ec_number_list": [], "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0045095 keratin filament", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0045109 intermediate filament organization;GO:0002009 morphogenesis of an epithelium", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q61765-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63ZV0-1", "uniprot_id": [ { "id": "INSM1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q63ZV0", "type": "external" } ], "mass": 54050.0, "length": 521, "protein_name": "Insulinoma-associated protein 1", "gene_name": "Insm1", "organism": "Mouse", "refseq_name": "insulinoma-associated protein 1", "refseq_ac": [ { "id": "NP_058585", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058585", "type": "external" } ], "gene_names_uniprotkb": "Insm1; Ia1", "gene_names_refseq": "IA-1; Insm1", "protein_names_uniprotkb": "Insulinoma-associated protein 1; Zinc finger protein IA-1", "protein_names_refseq": "insulinoma-associated protein (IA-1); insulinoma-associated protein 1; zinc finger protein IA-1", "tax_id": 10090, "disease": "brain cancer (Disease Ontology:DOID:1319)", "pathway": " (mmu:53626)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12079283;12890672;16511571;16951258;18094025;18940587;24227653;30084848;34428180", "class_list": "", "function": "Isolation, characterization, and identification of an interacting protein, Cbl-associated protein (CAP), [RefSeq, PubMed]; Sequence-specific DNA-binding transcriptional regulator that plays a key role in neurogenesis and neuroendocrine cell differentiation during embryonic and/or fetal development. Binds to the consensus sequence 5'-[TG][TC][TC][TT][GA]GGG[CG]A-3' in target promoters. Acts as a transcriptional repressor of NEUROD1 and INS expression via its interaction with cyclin CCND1 in a cell cycle-independent manner. Negatively regulates skeletal muscle-specific gene expression in endocrine cells of the pituitary by inhibiting the Notch signaling pathway. Represses target gene transcription by recruiting chromatin-modifying factors, such as HDAC1, HDAC2, HDAC3, KDM1A and RCOR1 histone deacetylases. Binds to its own promoter, suggesting autoregulation as a self-control feedback mechanism. Competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4' (By similarity). Promotes the generation and expansion of neuronal basal progenitor cells in the developing neocortex. Involved in the differentiation of endocrine cells of the developing anterior pituitary gland, of the pancreas and intestine, and of sympatho-adrenal cells in the peripheral nervous system. Promotes cell cycle signaling arrest and inhibition of cellular proliferation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9Z113", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0042826 histone deacetylase binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0017053 transcription repressor complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0008284 positive regulation of cell population proliferation;GO:0008285 negative regulation of cell population proliferation;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q63ZV0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IE32-1", "uniprot_id": [ { "id": "ISK7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6IE32", "type": "external" } ], "mass": 9282.0, "length": 85, "protein_name": "Serine protease inhibitor Kazal-type 7", "gene_name": "Spink7", "organism": "Mouse", "refseq_name": "serine protease inhibitor Kazal-type 7 precursor", "refseq_ac": [ { "id": "NP_001001803", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001803", "type": "external" } ], "gene_names_uniprotkb": "Spink7; Ecg2", "gene_names_refseq": "ECRG-2; EG408198; Ecg2; Spink7", "protein_names_uniprotkb": "Serine protease inhibitor Kazal-type 7; ECRG-2; Esophagus cancer-related gene 2 protein", "protein_names_refseq": "esophagus cancer-related gene 2 protein; esophagus cancer-related gene-2; serine protease inhibitor Kazal-type 7 precursor; serine protease inhibitor Kazal-type 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:408198)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15060002;33722746", "class_list": "", "function": "Neutrophils-derived Spink7 as one safeguard against experimental murine colitis., [RefSeq, PubMed]; Probable serine protease inhibitor., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F8WGH2", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0006954 inflammatory response;GO:1900016 negative regulation of cytokine production involved in inflammatory response;GO:0045861 negative regulation of proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6IE32-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IFX4-1", "uniprot_id": [ { "id": "K1C39_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6IFX4", "type": "external" } ], "mass": 54287.0, "length": 482, "protein_name": "Keratin, type I cytoskeletal 39", "gene_name": "Krt39", "organism": "Mouse", "refseq_name": "keratin, type I cytoskeletal 39", "refseq_ac": [ { "id": "NP_998895", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998895", "type": "external" } ], "gene_names_uniprotkb": "Krt39; Ka35", "gene_names_refseq": "4732494G06Rik; Ka35; Krt39", "protein_names_uniprotkb": "Keratin, type I cytoskeletal 39; CK-39; Cytokeratin-39; K39; Keratin-39; Type I hair keratin Ka35", "protein_names_refseq": "CK-39; K39; cytokeratin-39; keratin, type I cytoskeletal 39; ortholog of type I hair keratin KA35; type I hair keratin KA35", "tax_id": 10090, "disease": "", "pathway": " (mmu:237934); (R-MMU-6805567); (R-MMU-6809371)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "15085952", "class_list": "", "function": "May play a role in late hair differentiation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2VCT4;Q0VDS4", "ec_number_list": [], "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0045095 keratin filament", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0045109 intermediate filament organization;GO:0002009 morphogenesis of an epithelium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6IFX4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IFZ9-1", "uniprot_id": [ { "id": "K2C74_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6IFZ9", "type": "external" } ], "mass": 54747.0, "length": 495, "protein_name": "Keratin, type II cytoskeletal 74", "gene_name": "Krt74", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Krt74; Kb37", "gene_names_refseq": "", "protein_names_uniprotkb": "Keratin, type II cytoskeletal 74; K74; Keratin-74; Type-II keratin Kb37", "protein_names_refseq": "", "tax_id": 10090, "disease": "hypotrichosis 3 (Disease Ontology:DOID:0110700); autosomal dominant woolly hair (Disease Ontology:DOID:0111573); ectodermal dysplasia 7 (Disease Ontology:DOID:0111660)", "pathway": " (R-MMU-6805567); (R-MMU-6809371)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "15085952;24714551;25428506;26495903;31599954", "class_list": "", "function": "Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990254 keratin filament binding;GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005737 cytoplasm;GO:0045095 keratin filament", "go_biological_process": "GO:0031424 keratinization;GO:0045109 intermediate filament organization;GO:0045104 intermediate filament cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6IFZ9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IME9-1", "uniprot_id": [ { "id": "K2C72_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6IME9", "type": "external" } ], "mass": 56750.0, "length": 520, "protein_name": "Keratin, type II cytoskeletal 72", "gene_name": "Krt72", "organism": "Mouse", "refseq_name": "keratin, type II cytoskeletal 72", "refseq_ac": [ { "id": "NP_998893", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998893", "type": "external" } ], "gene_names_uniprotkb": "Krt72; Kb35; Krt72-ps", "gene_names_refseq": "CK-72; K6irs2; K72; Krt2-35; Krt72-ps; Krt72", "protein_names_uniprotkb": "Keratin, type II cytoskeletal 72; CK-72; Cytokeratin-72; K72; Keratin-72; Type II inner root sheath-specific keratin-K6irs2; Type-II keratin Kb35", "protein_names_refseq": "cytokeratin-72; keratin 72, pseudogene; keratin complex 2, basic, gene 35; keratin, type II cytoskeletal 72; type II inner root sheath-specific keratin-K6irs2; type-II keratin Kb35", "tax_id": 10090, "disease": "", "pathway": " (mmu:105866); (R-MMU-6805567); (R-MMU-6809371)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "15085952;34428180;39627609", "class_list": "", "function": "Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0045095 keratin filament", "go_biological_process": "GO:0031424 keratinization;GO:0045109 intermediate filament organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6IME9-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6RHW0-1", "uniprot_id": [ { "id": "K1C9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6RHW0", "type": "external" } ], "mass": 72495.0, "length": 743, "protein_name": "Keratin, type I cytoskeletal 9", "gene_name": "Krt9", "organism": "Mouse", "refseq_name": "keratin, type I cytoskeletal 9", "refseq_ac": [ { "id": "NP_957707", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_957707", "type": "external" } ], "gene_names_uniprotkb": "Krt9; K9; Krt1-9", "gene_names_refseq": "EPPK; K9; Krt1-9; Krt9", "protein_names_uniprotkb": "Keratin, type I cytoskeletal 9; CK-9; Cytokeratin-9; K9; Keratin-9", "protein_names_refseq": "CK-9; cytokeratin-9; keratin complex 1, acidic, gene 9; keratin, type I cytoskeletal 9", "tax_id": 10090, "disease": "epidermolytic palmoplantar keratoderma 1 (Disease Ontology:DOID:0070552)", "pathway": " (mmu:107656); (R-MMU-6805567); (R-MMU-6809371)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "16015579;34428180", "class_list": "", "function": "Intron 6 influences the transcriptional efficiency of the keratin 9 (K9, Krt1-9) gene by decreasing production of wild-type K9 and changing the expression of K9 proteins., [RefSeq, PubMed]; Structural component of intermediate filaments in suprabasal keratinocytes of palmoplantar epidermis. Forms heteropolymers with a type II keratin, assembling into keratin intermediate filament networks that maintain the mechanical integrity of the palmoplantar epidermis (By similarity). Plays an essential role in the correct development of sperm (PubMed:16015579)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A4G3", "ec_number_list": [], "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0048471 perinuclear region of cytoplasm;GO:0045095 keratin filament", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030855 epithelial cell differentiation;GO:0043588 skin development;GO:0045109 intermediate filament organization;GO:0002009 morphogenesis of an epithelium", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6RHW0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TMY7-1", "uniprot_id": [ { "id": "IPO8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TMY7", "type": "external" } ], "mass": 117078.0, "length": 1010, "protein_name": "Importin-8", "gene_name": "Ipo8", "organism": "Mouse", "refseq_name": "importin-8 isoform 1", "refseq_ac": [ { "id": "NP_001074582", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074582", "type": "external" } ], "gene_names_uniprotkb": "Ipo8", "gene_names_refseq": "6230418K12Rik; Abcc10; C130009K11Rik; Ipo8; MRP7; OM-1; Om1; Ranbp8", "protein_names_uniprotkb": "Importin-8; Imp8; Ran-binding protein 8; RanBP8", "protein_names_refseq": "ATP-binding cassette, sub-family C (CFTR/MRP), member 10; imp8; importin-8 isoform 1; oocyte maturation 1; ran-binding protein 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:320727); (R-MMU-5578749)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "17242355;20173027;21750661;24596094;25428506;30084848;30779550;31219806;34010605;34428180;35922041;39627609", "class_list": "", "function": "Importin 8 plays a critical role in mediating the cytoplasm-to-nucleus transport of mature miRNAs. IPO8-mediated nuclear transport of mature miRNAs is also dependent on the association of IPO8 with the Argonaute 2 complex., [RefSeq, PubMed]; Involved in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, may serve as receptor for nuclear localization signals (NLS) and promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro mediates the nuclear import of the signal recognition particle protein SRP19. May also be involved in cytoplasm-to-nucleus shuttling of a broad spectrum of other cargos, including Argonaute-microRNAs complexes, the JUN protein, RELA/NF-kappa-B p65 subunit, the translation initiation factor EIF4E and a set of receptor-activated mothers against decapentaplegic homolog (SMAD) transcription factors that play a critical role downstream of the large family of transforming growth factor beta and bone morphogenetic protein (BMP) cytokines., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2KGD8;Q811I3;Q8C8A9;Q8R2P6;Q8R3V7", "ec_number_list": [], "go_molecular_function": "GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0031267 small GTPase binding;GO:0061608 nuclear import signal receptor activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005634 nucleus", "go_biological_process": "GO:0006606 protein import into nucleus;GO:0006886 intracellular protein transport;GO:0006913 nucleocytoplasmic transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q7TMY7-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80WT0-1", "uniprot_id": [ { "id": "JPH4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80WT0", "type": "external" } ], "mass": 66000.0, "length": 628, "protein_name": "Junctophilin-4", "gene_name": "Jph4", "organism": "Mouse", "refseq_name": "junctophilin-4", "refseq_ac": [ { "id": "NP_796023", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796023", "type": "external" } ], "gene_names_uniprotkb": "Jph4; Jphl1", "gene_names_refseq": "9330157P13Rik; JP-4; JPHL1; Jph4", "protein_names_uniprotkb": "Junctophilin-4; JP-4; Junctophilin-like 1 protein", "protein_names_refseq": "junctophilin-4; junctophilin-like 1 protein", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700)", "pathway": " (mmu:319984)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "14559359;16809425;17904530;26929330;31461656", "class_list": "", "function": "Data show that junctophilin-4 (JP4) is expressed in T cells and localized at the endoplasmic reticulum-plasma membrane junctions to regulate Ca(2+) signaling., [RefSeq, PubMed]; Gene expression was slightly altered in the JP-3 and JP-4 Knockout cerebellum., [RefSeq, PubMed]; Jph4 seems to have an essential role in neural excitability fundamental to plasticity and integrated functions., [RefSeq, PubMed]; Junctophilin Proteins Tether a Cav1-RyR2-KCa3.1 Tripartite Complex to Regulate Neuronal Excitability., [RefSeq, PubMed]; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH4 is brain-specific and appears to have an active role in certain neurons involved in motor coordination and memory., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q69FB2;Q8BMI1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005790 smooth endoplasmic reticulum;GO:0005886 plasma membrane;GO:0043198 dendritic shaft;GO:0005789 endoplasmic reticulum membrane;GO:0030314 junctional membrane complex", "go_biological_process": "GO:0007612 learning;GO:0050885 neuromuscular process controlling balance;GO:0048167 regulation of synaptic plasticity;GO:0001817 regulation of cytokine production;GO:2001256 regulation of store-operated calcium entry", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q80WT0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80XH2-1", "uniprot_id": [ { "id": "IMPG2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80XH2", "type": "external" } ], "mass": 138102.0, "length": 1243, "protein_name": "Interphotoreceptor matrix proteoglycan 2", "gene_name": "Impg2", "organism": "Mouse", "refseq_name": "interphotoreceptor matrix proteoglycan 2 precursor", "refseq_ac": [ { "id": "NP_777365", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777365", "type": "external" } ], "gene_names_uniprotkb": "Impg2", "gene_names_refseq": "IPM200; Impg2; PG10.2; Rsbp; Spacrcan", "protein_names_uniprotkb": "Interphotoreceptor matrix proteoglycan 2; Sialoprotein associated with cones and rods proteoglycan; Spacrcan", "protein_names_refseq": "interphotoreceptor matrix proteoglycan 2 precursor; sialoprotein associated with cones and rods proteoglycan", "tax_id": 10090, "disease": "vitelliform macular dystrophy (Disease Ontology:DOID:0050661); retinitis pigmentosa 56 (Disease Ontology:DOID:0110371)", "pathway": " (mmu:224224)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12589770;15044457;25428506;25605945;29777959;32265257;35820727;37440072;37975905", "class_list": "", "function": "Chondroitin sulfate- and hyaluronan-binding proteoglycan involved in the organization of interphotoreceptor matrix; may participate in the maturation and maintenance of the light-sensitive photoreceptor outer segment. Binds heparin., [UniProtKB, UniProtKB]; Heterogeneity in the progression of retinal pathologies in mice harboring patient mimicking Impg2 mutations. Erratum:[Hum Mol Genet. 2024 Feb 18;33(5):475-476. doi: 10.1093/hmg/ddae004. PMID: 38217426], [RefSeq, PubMed]; May play an important role in photoreceptor development and maintenance., [RefSeq, PubMed]; Proteoglycan IMPG2 Shapes the Interphotoreceptor Matrix and Modulates Vision. Erratum:[J Neurosci. 2020 Aug 19;40(34):6660. doi: 10.1523/JNEUROSCI.1846-20.2020. PMID: 32737169], [RefSeq, PubMed]; Retinal Metabolic Profile on IMPG2 Deficiency Mice with Subretinal Lesions., [RefSeq, PubMed]", "predicted_glycosites": 15, "predicted_n_glycosites": 7, "predicted_o_glycosites": 8, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 15, "binding_glycan_count": 0, "secondary_ac_list": "Q810Y3;Q8C8E4", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0005540 hyaluronic acid binding", "go_cellular_component": "GO:0033165 interphotoreceptor matrix;GO:0031012 extracellular matrix;GO:0043235 receptor complex;GO:0140150 gel phase of interstitial matrix", "go_biological_process": "GO:0060042 retina morphogenesis in camera-type eye;GO:0030198 extracellular matrix organization;GO:0007601 visual perception;GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q80XH2-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q810A5-1", "uniprot_id": [ { "id": "MACA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q810A5", "type": "external" } ], "mass": 53170.0, "length": 467, "protein_name": "Microtubule-associated tyrosine carboxypeptidase 1", "gene_name": "Matcap1", "organism": "Mouse", "refseq_name": "microtubule-associated tyrosine carboxypeptidase 1", "refseq_ac": [ { "id": "NP_001159866", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159866", "type": "external" } ], "gene_names_uniprotkb": "Matcap1; Matcap", "gene_names_refseq": "4931428F04Rik; Kiaa0895l; MATCAP; Matcap1", "protein_names_uniprotkb": "Microtubule-associated tyrosine carboxypeptidase 1; 3.4.17.17", "protein_names_refseq": "microtubule-associated tyrosine carboxypeptidase 1; microtubule-associated tyrosine carboxypeptidase", "tax_id": 10090, "disease": "", "pathway": " (mmu:74356)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "35482892;40021952", "class_list": "", "function": "Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function (PubMed:35482892). Also able to remove the C-terminal phenylalanine residue of alpha-tubulin TUBA8. Recognizes adjacent tubulin dimers along the same protofilament (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9D4J6", "ec_number_list": [ { "id": "3.4.17.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.17", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004181 metallocarboxypeptidase activity;GO:0106423 tubulin-tyrosine carboxypeptidase", "go_cellular_component": "GO:0005874 microtubule", "go_biological_process": "GO:0006508 proteolysis;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q810A5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGZ7-1", "uniprot_id": [ { "id": "K2C75_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGZ7", "type": "external" } ], "mass": 59741.0, "length": 551, "protein_name": "Keratin, type II cytoskeletal 75", "gene_name": "Krt75", "organism": "Mouse", "refseq_name": "keratin, type II cytoskeletal 75", "refseq_ac": [ { "id": "NP_579935", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_579935", "type": "external" } ], "gene_names_uniprotkb": "Krt75; Kb18", "gene_names_refseq": "4732468K03Rik; K6hf; Krt2-6hf; Krt75; Krtcap1", "protein_names_uniprotkb": "Keratin, type II cytoskeletal 75; CK-75; Cytokeratin-75; K75; Keratin-6 hair follicle; Keratin-75; Type II keratin-K6hf; Type-II keratin Kb18; mK6hf", "protein_names_refseq": "CK-75; K75; cytokeratin KRT2-6HF; cytokeratin-75; keratin 75 activity-regulated; keratin, type II cytoskeletal 75; keratin-6 hair follicle; keratinocyte associated protein 1; mK6hf; type II keratin-K6hf; type-II keratin Kb18", "tax_id": 10090, "disease": "", "pathway": " (mmu:109052); (R-MMU-6805567); (R-MMU-6809371)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "11489919;14675170;17170733;17851587;31628189;34428180;35984892;36583994", "class_list": "", "function": "MK6a and mK75 thus exhibit temporally distinct, and spatially opposed, expression patterns in the companion layer (Cl) during postnatal anagen., [RefSeq, PubMed]; Mice expressing mutant form of Krt75 developed hair and nail defects resembling pachyonychia congenita, [RefSeq, PubMed]; Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle (By similarity)., [UniProtKB, PubMed]; Results indicate that keratin 75 (K75), a cytosolic protein lacking a signal sequence, is secreted into the forming enamel matrix utilizing portions of the conventional endoplasmic reticulum (ER)-Golgi secretory pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RQH6", "ec_number_list": [], "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005882 intermediate filament;GO:0001533 cornified envelope;GO:0045095 keratin filament", "go_biological_process": "GO:0031424 keratinization;GO:0045109 intermediate filament organization;GO:0002244 hematopoietic progenitor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BGZ7-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BJD1-1", "uniprot_id": [ { "id": "ITIH5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BJD1", "type": "external" } ], "mass": 106749.0, "length": 952, "protein_name": "Inter-alpha-trypsin inhibitor heavy chain H5", "gene_name": "Itih5", "organism": "Mouse", "refseq_name": "inter-alpha-trypsin inhibitor heavy chain H5 precursor", "refseq_ac": [ { "id": "NP_766059", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766059", "type": "external" } ], "gene_names_uniprotkb": "Itih5", "gene_names_refseq": "4631408O11Rik; 5430408M01Rik; E130106B02; Itih5", "protein_names_uniprotkb": "Inter-alpha-trypsin inhibitor heavy chain H5; ITI heavy chain H5; ITI-HC5; Inter-alpha-inhibitor heavy chain 5", "protein_names_refseq": "ITI heavy chain H5; ITI-HC5; inter-alpha (globulin) inhibitor H5; inter-alpha trypsin inhibitor heavy chain precursor 5; inter-alpha-inhibitor heavy chain 5; inter-alpha-trypsin inhibitor heavy chain H5 precursor; inter-alpha-trypsin inhibitor heavy chain H5", "tax_id": 10090, "disease": "", "pathway": " (mmu:209378)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;30899004;32799206;34428180;39198923", "class_list": "", "function": "Genetic deletion of ITIH5 leads to increased development of adipose tissue in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Inter-alpha-Trypsin Inhibitor Heavy Chain 5 (ITIH5) Is a Natural Stabilizer of Hyaluronan That Modulates Biological Processes in the Skin., [RefSeq, PubMed]; May act as a tumor suppressor., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 6, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q3US68;Q80VG0", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix", "go_biological_process": "GO:0030212 hyaluronan metabolic process;GO:0060065 uterus development", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8BJD1-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BNL5-1", "uniprot_id": [ { "id": "KCTD6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BNL5", "type": "external" } ], "mass": 27624.0, "length": 237, "protein_name": "BTB/POZ domain-containing protein KCTD6", "gene_name": "Kctd6", "organism": "Mouse", "refseq_name": "BTB/POZ domain-containing protein KCTD6", "refseq_ac": [ { "id": "NP_001292865", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001292865", "type": "external" } ], "gene_names_uniprotkb": "Kctd6", "gene_names_refseq": "5430433B02Rik; Kctd6", "protein_names_uniprotkb": "BTB/POZ domain-containing protein KCTD6", "protein_names_refseq": "BTB/POZ domain-containing protein KCTD6", "tax_id": 10090, "disease": "", "pathway": " (mmu:71393); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "21472142;31219806", "class_list": "", "function": "Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1; the function seems to depend on KCTD11:KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Involved in regulating protein levels of ANK1 isoform Mu7 probably implicating CUL3-dependent proteasomal degradation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TXX1", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0097602 cullin family protein binding;GO:0030506 ankyrin binding", "go_cellular_component": "GO:0031430 M band", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0045879 negative regulation of smoothened signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BNL5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BPW0-1", "uniprot_id": [ { "id": "IQCJ_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BPW0", "type": "external" } ], "mass": 12662.0, "length": 110, "protein_name": "IQ domain-containing protein J", "gene_name": "Iqcj", "organism": "Mouse", "refseq_name": "IQ domain-containing protein J", "refseq_ac": [ { "id": "NP_808253", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808253", "type": "external" } ], "gene_names_uniprotkb": "Iqcj", "gene_names_refseq": "D230050A05; EG208426; Iqcj", "protein_names_uniprotkb": "IQ domain-containing protein J", "protein_names_refseq": "IQ domain-containing protein J", "tax_id": 10090, "disease": "", "pathway": " (mmu:208426)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "18550753", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BPW0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C828-1", "uniprot_id": [ { "id": "KBTBD_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C828", "type": "external" } ], "mass": 49769.0, "length": 458, "protein_name": "Kelch repeat and BTB domain-containing protein 13", "gene_name": "Kbtbd13", "organism": "Mouse", "refseq_name": "kelch repeat and BTB domain-containing protein 13", "refseq_ac": [ { "id": "NP_083250", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083250", "type": "external" } ], "gene_names_uniprotkb": "Kbtbd13", "gene_names_refseq": "5430433E21Rik; Kbtbd13", "protein_names_uniprotkb": "Kelch repeat and BTB domain-containing protein 13", "protein_names_refseq": "kelch repeat and BTB domain-containing protein 13", "tax_id": 10090, "disease": "nemaline myopathy 6 (Disease Ontology:DOID:0110935)", "pathway": " (mmu:74492); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "21109227;31671076;36335629", "class_list": "", "function": "KBTBD13 is a novel cardiomyopathy gene., [RefSeq, PubMed]; KBTBD13 is an actin-binding protein that modulates muscle kinetics. Erratum:[J Clin Invest. 2024 Feb 01;134(3):e179111. doi: 10.1172/JCI179111. PMID: 38299595], [RefSeq, PubMed]; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding", "go_cellular_component": "GO:0030018 Z disc;GO:0030016 myofibril;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0007015 actin filament organization;GO:0016567 protein ubiquitination;GO:0014728 regulation of the force of skeletal muscle contraction;GO:0090076 relaxation of skeletal muscle", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8C828-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CDK3-1", "uniprot_id": [ { "id": "IQUB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CDK3", "type": "external" } ], "mass": 92130.0, "length": 788, "protein_name": "IQ motif and ubiquitin-like domain-containing protein", "gene_name": "Iqub", "organism": "Mouse", "refseq_name": "IQ motif and ubiquitin-like domain-containing protein", "refseq_ac": [ { "id": "NP_766123", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766123", "type": "external" } ], "gene_names_uniprotkb": "Iqub", "gene_names_refseq": "4932408B21Rik; Iqub; Trs4", "protein_names_uniprotkb": "IQ motif and ubiquitin-like domain-containing protein", "protein_names_refseq": "IQ and ubiquitin-like domain-containing protein; IQ motif and ubiquitin-like domain-containing protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:214704)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21289087;36355624;36417862", "class_list": "", "function": "Anchors the radial spoke 1 (RS1) complex to the A microtubule of outer doublet microtubules in axonemes (PubMed:36355624, PubMed:36417862). The triple radial spokes (RS1, RS2 and RS3) are required to modulate beating of the sperm flagellum (PubMed:36355624, PubMed:36417862). May play a role in inhibiting signaling via MAPK1/ERK2 and MAPK3/ERK1 (PubMed:36355624). Additionally, may play a role in the functioning of cilia (PubMed:21289087). Not required for the functioning of tracheal or ependymal cilia (PubMed:36417862)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RQH8;Q3TT98", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0001534 radial spoke;GO:0005576 extracellular region;GO:0031514 motile cilium;GO:0001669 acrosomal vesicle;GO:0036126 sperm flagellum", "go_biological_process": "GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0030317 flagellated sperm motility;GO:0060271 cilium assembly;GO:0007224 smoothened signaling pathway;GO:0003341 cilium movement", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8CDK3-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K0C1-1", "uniprot_id": [ { "id": "IPO13_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K0C1", "type": "external" } ], "mass": 108229.0, "length": 963, "protein_name": "Importin-13", "gene_name": "Ipo13", "organism": "Mouse", "refseq_name": "importin-13 isoform 1", "refseq_ac": [ { "id": "NP_666264", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666264", "type": "external" } ], "gene_names_uniprotkb": "Ipo13; Kiaa0724", "gene_names_refseq": "Imp13; Ipo13; Kap13; Ranbp13", "protein_names_uniprotkb": "Importin-13; Imp13", "protein_names_refseq": "importin-13 isoform 1", "tax_id": 10090, "disease": "microphthalmia (Disease Ontology:DOID:10629); cataract (Disease Ontology:DOID:83)", "pathway": " (mmu:230673)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "16908015;27993670;33082305;33333437;34428180;34625540;35741036", "class_list": "", "function": "Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13 (By similarity)., [UniProtKB]; IPO13 has a stage-specific role in nuclear-cytoplasmic translocation of cargoes that accompanies meiotic differentiation of the mouse germ cells, [RefSeq, PubMed]; Importin 13 promotes NSCLC progression by mediating RFPL3 nuclear translocation and hTERT expression upregulation. Publication Status: Online-Only, [RefSeq, PubMed]; Interactome of the inhibitory isoform of the nuclear transporter Importin 13 has been reported., [RefSeq, PubMed]; Nuclear Transporter IPO13 Is Central to Efficient Neuronal Differentiation. Publication Status: Online-Only, [RefSeq, PubMed]; Nuclear transporter Importin-13 plays a key role in the oxidative stress transcriptional response. Publication Status: Online-Only, [RefSeq, PubMed]; The nuclear transporter importin 13 is critical for cell survival during embryonic stem cell differentiation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZQ60", "ec_number_list": [], "go_molecular_function": "GO:0035259 nuclear glucocorticoid receptor binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8K0C1-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K177-1", "uniprot_id": [ { "id": "KCP3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K177", "type": "external" } ], "mass": 25687.0, "length": 240, "protein_name": "Keratinocyte-associated protein 3", "gene_name": "Krtcap3", "organism": "Mouse", "refseq_name": "keratinocyte-associated protein 3", "refseq_ac": [ { "id": "NP_081497", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081497", "type": "external" } ], "gene_names_uniprotkb": "Krtcap3", "gene_names_refseq": "2010001C09Rik; Kcp3; Krtcap3", "protein_names_uniprotkb": "Keratinocyte-associated protein 3; KCP-3", "protein_names_refseq": "KCP-3; keratinocyte-associated protein 3; keratinocytes associated protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:69815)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D8I7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8K177-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R179-1", "uniprot_id": [ { "id": "KBTB4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R179", "type": "external" } ], "mass": 59857.0, "length": 534, "protein_name": "Kelch repeat and BTB domain-containing protein 4", "gene_name": "Kbtbd4", "organism": "Mouse", "refseq_name": "kelch repeat and BTB domain-containing protein 4 isoform 1", "refseq_ac": [ { "id": "NP_001298045", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001298045", "type": "external" } ], "gene_names_uniprotkb": "Kbtbd4; Bklhd4", "gene_names_refseq": "2510026C23Rik; Kbtbd4", "protein_names_uniprotkb": "Kelch repeat and BTB domain-containing protein 4; BTB and kelch domain-containing protein 4", "protein_names_refseq": "kelch repeat and BTB domain-containing protein 4 isoform 1; kelch repeat and BTB domain-containing protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:67136)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "31599954;34428180", "class_list": "", "function": "Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex which targets CoREST corepressor complex components RCOR1, KDM1A/LSD1 and HDAC2 for proteasomal degradation. RCOR1 is likely to be the primary target while degradation of KDM1A and HDAC2 is likely due to their association with RCOR1. Also targets RCOR3, MIER2 and MIER3 for proteasomal degradation as well as associated proteins ZNF217 and RREB1. Degradation is dependent on the presence of an ELM2 domain in the target proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AFW3;Q9CQX1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8R179-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R1W8-1", "uniprot_id": [ { "id": "IMPG1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R1W8", "type": "external" } ], "mass": 89474.0, "length": 798, "protein_name": "Interphotoreceptor matrix proteoglycan 1", "gene_name": "Impg1", "organism": "Mouse", "refseq_name": "interphotoreceptor matrix proteoglycan 1 precursor", "refseq_ac": [ { "id": "NP_071299", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071299", "type": "external" } ], "gene_names_uniprotkb": "Impg1; Spacr", "gene_names_refseq": "A930015H12Rik; IMP150; Impg1; SPACR", "protein_names_uniprotkb": "Interphotoreceptor matrix proteoglycan 1; IPM-150; Interphotoreceptor matrix proteoglycan of 150 kDa; Sialoprotein associated with cones and rods", "protein_names_refseq": "IPM-150; interphotoreceptor matrix proteoglycan 1 precursor; interphotoreceptor matrix proteoglycan of 150 kDa; sialoprotein associated with cones and rods", "tax_id": 10090, "disease": "vitelliform macular dystrophy (Disease Ontology:DOID:0050661); retinitis pigmentosa 91 (Disease Ontology:DOID:0061106)", "pathway": " (mmu:63859)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;10958699;10995555;21750661;29777959;36140676", "class_list": "", "function": "Chondroitin sulfate-, heparin- and hyaluronan-binding protein (By similarity). May serve to form a basic macromolecular scaffold comprising the insoluble interphotoreceptor matrix (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Chondroitin sulfate-, heparin- and hyaluronan-binding protein. May serve to form a basic macromolecular scaffold comprising the insoluble interphotoreceptor matrix., [UniProtKB, UniProtKB]; Murine orthologue of the human retinal glycoprotein IPM 150 (IMPG1), involved in retinal adhesion and photoreceptor cell survival. Analyses of IPM 150 and IPM 200 core proteins reveals the presence of multiple conserved domain of unknown function. Publication Status: Online-Only, [RefSeq, PubMed]; SPACR Encoded by IMPG1 Is Essential for Photoreceptor Survival by Interplaying between the Interphotoreceptor Matrix and the Retinal Pigment Epithelium. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 1, "predicted_o_glycosites": 7, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "Q9CTP8;Q9ES62;Q9ET31", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0035374 chondroitin sulfate binding;GO:0005540 hyaluronic acid binding", "go_cellular_component": "GO:0033165 interphotoreceptor matrix;GO:0001917 photoreceptor inner segment;GO:0001750 photoreceptor outer segment;GO:0140150 gel phase of interstitial matrix", "go_biological_process": "GO:0030198 extracellular matrix organization;GO:0007601 visual perception", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8R1W8-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VDV0-1", "uniprot_id": [ { "id": "ITGBL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VDV0", "type": "external" } ], "mass": 53978.0, "length": 494, "protein_name": "Integrin beta-like protein 1", "gene_name": "Itgbl1", "organism": "Mouse", "refseq_name": "integrin beta-like protein 1 precursor", "refseq_ac": [ { "id": "NP_663442", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663442", "type": "external" } ], "gene_names_uniprotkb": "Itgbl1", "gene_names_refseq": "B930011D01Rik; Itgbl1", "protein_names_uniprotkb": "Integrin beta-like protein 1", "protein_names_refseq": "integrin beta-like protein 1 precursor; integrin beta-like protein 1; with EGF-like repeat domains", "tax_id": 10090, "disease": "", "pathway": " (mmu:223272)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;30305454;33413419;37395147", "class_list": "", "function": "ITGBL1 is a new immunomodulator that favors development of melanoma tumors by inhibiting natural killer cells cytotoxicity. Erratum:[Mol Cancer. 2021 Jan 27;20(1):21. doi: 10.1186/s12943-021-01319-5. PMID: 33504341] Publication Status: Online-Only, [RefSeq, PubMed]; Integrin beta-like 1 mediates fibroblast-cardiomyocyte crosstalk to promote cardiac fibrosis and hypertrophy., [RefSeq, PubMed]; These results reveal ITGBL1 signaling as an underlying mechanism of protection against destructive cartilage disorders, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BKJ4;Q8BMS0", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005925 focal adhesion;GO:0009986 cell surface;GO:0008305 integrin complex", "go_biological_process": "GO:0007229 integrin-mediated signaling pathway;GO:0016477 cell migration;GO:0007160 cell-matrix adhesion;GO:0033627 cell adhesion mediated by integrin;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8VDV0-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91X21-1", "uniprot_id": [ { "id": "K2013_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91X21", "type": "external" } ], "mass": 69425.0, "length": 634, "protein_name": "Uncharacterized protein KIAA2013", "gene_name": "Kiaa2013", "organism": "Mouse", "refseq_name": "uncharacterized protein KIAA2013 precursor", "refseq_ac": [ { "id": "NP_084117", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084117", "type": "external" } ], "gene_names_uniprotkb": "Kiaa2013", "gene_names_refseq": "2510039O18Rik; Kiaa2013", "protein_names_uniprotkb": "Uncharacterized protein KIAA2013", "protein_names_refseq": "uncharacterized protein KIAA2013 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:77034)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "25605945;34428180;37828378", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 1, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B2KFU4;Q3U5A6;Q69Z34;Q9CY11", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q91X21-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q920P5-1", "uniprot_id": [ { "id": "KAD5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q920P5", "type": "external" } ], "mass": 63323.0, "length": 562, "protein_name": "Adenylate kinase isoenzyme 5", "gene_name": "Ak5", "organism": "Mouse", "refseq_name": "adenylate kinase isoenzyme 5 isoform 1", "refseq_ac": [ { "id": "NP_001074746", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074746", "type": "external" } ], "gene_names_uniprotkb": "Ak5", "gene_names_refseq": "Ak5", "protein_names_uniprotkb": "Adenylate kinase isoenzyme 5; 2.7.4.3; 2.7.4.6; AK 5; ATP-AMP transphosphorylase 5", "protein_names_refseq": "ATP-AMP transphosphorylase 5; adenylate kinase isoenzyme 5 isoform 1; adenylate kinase isoenzyme 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:229949); (R-MMU-499943)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "16959763;21750661", "class_list": "", "function": "Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. Also displays broad nucleoside diphosphate kinase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.4", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.7.4.14", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.14", "type": "external" } ], "go_molecular_function": "GO:0004017 AMP kinase activity;GO:0005524 ATP binding;GO:0004550 nucleoside diphosphate kinase activity;GO:0019205 nucleobase-containing compound kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0034451 centriolar satellite", "go_biological_process": "GO:0046034 ATP metabolic process;GO:0006139 nucleobase-containing compound metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q920P5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99NG9-1", "uniprot_id": [ { "id": "K199B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99NG9", "type": "external" } ], "mass": 6031.0, "length": 58, "protein_name": "Keratin-associated protein 19-9b", "gene_name": "Krtap19-9b", "organism": "Mouse", "refseq_name": "keratin-associated protein 19-9b", "refseq_ac": [ { "id": "NP_579937", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_579937", "type": "external" } ], "gene_names_uniprotkb": "Krtap19-9b; Krtap16-10b; Krtap16.10L", "gene_names_refseq": "Krtap16-10b; Krtap16.10L; Krtap19-9b", "protein_names_uniprotkb": "Keratin-associated protein 19-9b; High-glycine/tyrosine protein type I E5; Keratin-associated protein 16-10-like; Keratin-associated protein 16-10b", "protein_names_refseq": "high-glycine/tyrosine protein type I E5; keratin associated protein 16-10B; keratin-associated protein 16-10b; keratin-associated protein 19-9b", "tax_id": 10090, "disease": "", "pathway": " (mmu:170939)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15385554;17151017", "class_list": "", "function": "In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins., [UniProtKB]; Krtap16 is a hair keratin-associated protein gene complex regulated by Hoxc13; localized to chromosome 16, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80VT9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0005882 intermediate filament", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q99NG9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99PS0-1", "uniprot_id": [ { "id": "K1C23_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99PS0", "type": "external" } ], "mass": 48027.0, "length": 422, "protein_name": "Keratin, type I cytoskeletal 23", "gene_name": "Krt23", "organism": "Mouse", "refseq_name": "keratin, type I cytoskeletal 23", "refseq_ac": [ { "id": "NP_203537", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_203537", "type": "external" } ], "gene_names_uniprotkb": "Krt23; Haik1; Krt1-23", "gene_names_refseq": "CK23; Haik1; K23; Krt1-23; Krt23", "protein_names_uniprotkb": "Keratin, type I cytoskeletal 23; CK-23; Cytokeratin-23; K23; Keratin-23", "protein_names_refseq": "cytokeratin-23; keratin complex 1, acidic, gene 23; keratin, type I cytoskeletal 23; type I intermediate filament cytokeratin", "tax_id": 10090, "disease": "", "pathway": " (mmu:94179); (R-MMU-6805567); (R-MMU-6809371)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "11135429;30697791", "class_list": "", "function": "PPARA and MYC bind to sites within the Krt23 promoter, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0045095 keratin filament", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0045109 intermediate filament organization;GO:0002009 morphogenesis of an epithelium", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q99PS0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CR20-1", "uniprot_id": [ { "id": "IR3IP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CR20", "type": "external" } ], "mass": 9017.0, "length": 82, "protein_name": "Immediate early response 3-interacting protein 1", "gene_name": "Ier3ip1", "organism": "Mouse", "refseq_name": "immediate early response 3-interacting protein 1", "refseq_ac": [ { "id": "NP_079685", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079685", "type": "external" } ], "gene_names_uniprotkb": "Ier3ip1", "gene_names_refseq": "1110057H19Rik; Ier3ip1", "protein_names_uniprotkb": "Immediate early response 3-interacting protein 1", "protein_names_refseq": "immediate early response 3-interacting protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66191)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;25428506;28915629;34428180;36322741", "class_list": "", "function": "IER3IP1 is critical for maintaining glucose homeostasis through regulating the endoplasmic reticulum function and survival of beta cells., [RefSeq, PubMed]; Regulator of endoplasmic reticulum secretion that acts as a key determinant of brain size. Required for secretion of extracellular matrix proteins. Required for correct brain development by depositing sufficient extracellular matrix proteins for tissue integrity and the proliferation of neural progenitors (By similarity). Acts as a regulator of the unfolded protein response (UPR) (PubMed:28915629)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:1901142 insulin metabolic process;GO:2000269 regulation of fibroblast apoptotic process;GO:0008285 negative regulation of cell population proliferation;GO:0015031 protein transport;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CR20-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D1P2-1", "uniprot_id": [ { "id": "KAT8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D1P2", "type": "external" } ], "mass": 52574.0, "length": 458, "protein_name": "Histone acetyltransferase KAT8", "gene_name": "Kat8", "organism": "Mouse", "refseq_name": "histone acetyltransferase KAT8 isoform 1", "refseq_ac": [ { "id": "NP_080646", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080646", "type": "external" } ], "gene_names_uniprotkb": "Kat8; Mof; Myst1", "gene_names_refseq": "2010203C02Rik; 5830450F21Rik; D7Ertd629e; Kat8; MOF; MYST-1; Myst1; mMof", "protein_names_uniprotkb": "Histone acetyltransferase KAT8; 2.3.1.-; 2.3.1.48; Lysine acetyltransferase 8; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1; MYST-1; Males-absent on the first protein homolog; Protein acetyltransferase KAT8; Protein propionyltransferase KAT8; mMof", "protein_names_refseq": "MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1; MYST histone acetyltransferase 1; histone acetyltransferase KAT8 isoform 1; histone acetyltransferase KAT8; histone acetyltransferase Myst1; lysine acetyltransferase 8; males-absent on the first protein homolog; probable histone acetyltransferase MYST1; protein acetyltransferase KAT8; protein propionyltransferase KAT8", "tax_id": 10090, "disease": "breast cancer (Disease Ontology:DOID:1612); clear cell renal cell carcinoma (Disease Ontology:DOID:4467)", "pathway": " (mmu:67773); (R-MMU-3214847); (R-MMU-9772755)", "pathway_count": 3, "publication_count": 22, "publication_id_list": "17335777;17967868;18541669;21217699;21750661;23523075;24842875;24898753;27768893;27827827;28506985;30842237;31219806;31576060;31794431;32502394;34059674;34428180;34707105;36210013;37813994;39392752", "class_list": "", "function": "Histone acetyltransferase that catalyzes histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) or 'Lys-16' (H4K16ac), depending on the context (PubMed:24842875, PubMed:24898753, PubMed:31794431, PubMed:32502394). Catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:17967868, PubMed:18541669, PubMed:24898753, PubMed:28506985). H4K16ac constitutes the only acetylation mark intergenerationally transmitted and regulates key biological processes, such as oogenesis, embryonic stem cell pluripotency, hematopoiesis or glucose metabolism (PubMed:27827827, PubMed:28506985, PubMed:32502394, PubMed:34707105). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (By similarity). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (PubMed:23523075). X up-regulation is required to compensate for autosomal biallelic expression (PubMed:23523075). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (PubMed:24842875). As part of the NSL histone acetyltransferase complex, catalyzes histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (By similarity). The NSL complex also acts as a regulator of gene expression in mitochondria: KAT8 associates with mitochondrial DNA and controls expression of respiratory genes in an acetyltransferase-dependent mechanism (PubMed:27768893). Also functions as an acetyltransferase for non-histone targets, such as ALKBH5, COX17, IRF3, KDM1A/LSD1, LMNA, PAX7 or TP53/p53 (PubMed:30842237, PubMed:31576060, PubMed:34059674). Acts as an inhibitor of antiviral immunity by acetylating IRF3, preventing IRF3 recruitment to promoters (PubMed:30842237). Acts as a regulator of asymmetric division in muscle stem cells by mediating acetylation of PAX7 (PubMed:34059674). As part of the NSL complex, acetylates TP53/p53 at 'Lys-120' (By similarity). Acts as a regulator of epithelial-to-mesenchymal transition as part of the NSL complex by mediating acetylation of KDM1A/LSD1 (By similarity). The NSL complex is required for nuclear architecture maintenance by mediating acetylation of LMNA (PubMed:31576060). Promotes mitochondrial integrity by catalyzing acetylation of COX17 (PubMed:37813994). In addition to protein acetyltransferase activity, able to mediate protein propionylation (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; MOF is an essential factor for embryogenesis and oncogenesis, [RefSeq, PubMed]; Mitochondrial MOF regulates energy metabolism in heart failure via ATP5B hyperacetylation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UIY0;Q8BJ69;Q8BJ76;Q8CI73", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.4.1.255", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.255", "type": "external" }, { "id": "2.3.1.259", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.259", "type": "external" }, { "id": "2.3.1.57", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.57", "type": "external" }, { "id": "2.3.1.80", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.80", "type": "external" }, { "id": "4.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0061733 protein-lysine-acetyltransferase activity;GO:0061920 protein propionyltransferase activity;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0035267 NuA4 histone acetyltransferase complex;GO:0016363 nuclear matrix", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0010506 regulation of autophagy;GO:0045892 negative regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0045815 transcription initiation-coupled chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q9D1P2-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D2H2-2", "uniprot_id": [ { "id": "KAD7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D2H2", "type": "external" } ], "mass": 70675.0, "length": 614, "protein_name": "Adenylate kinase 7", "gene_name": "Ak7", "organism": "Mouse", "refseq_name": "adenylate kinase 7", "refseq_ac": [ { "id": "NP_084463", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084463", "type": "external" } ], "gene_names_uniprotkb": "Ak7", "gene_names_refseq": "4930502N02Rik; AK 7; Ak7", "protein_names_uniprotkb": "Adenylate kinase 7; 2.7.4.3; 2.7.4.6; AK 7; ATP-AMP transphosphorylase 7", "protein_names_refseq": "ATP-AMP transphosphorylase 7; adenylate kinase 7; putative adenylate kinase 7", "tax_id": 10090, "disease": "spermatogenic failure 27 (Disease Ontology:DOID:0111928); hydrocephalus (Disease Ontology:DOID:10908)", "pathway": " (mmu:78801); (R-MMU-499943)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "18776131;29365104", "class_list": "", "function": "Data show that a mutation of the adenylate kinase 7 gene results in animals with pathological signs characteristic of primary ciliary dyskinesia, including ultrastructural ciliary defects and decreased ciliary beat frequency in respiratory epithelium., [RefSeq, PubMed]; Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity. Involved in maintaining ciliary structure and function., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BVH3", "ec_number_list": [ { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.4", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.7.4.14", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.14", "type": "external" } ], "go_molecular_function": "GO:0004017 AMP kinase activity;GO:0005524 ATP binding;GO:0004550 nucleoside diphosphate kinase activity;GO:0036431 dCMP kinase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0097228 sperm principal piece", "go_biological_process": "GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0007283 spermatogenesis;GO:0002437 inflammatory response to antigenic stimulus;GO:0007420 brain development;GO:0035082 axoneme assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D2H2-2", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D2K4-1", "uniprot_id": [ { "id": "IQCH_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D2K4", "type": "external" } ], "mass": 122605.0, "length": 1071, "protein_name": "IQ domain-containing protein H", "gene_name": "Iqch", "organism": "Mouse", "refseq_name": "IQ domain-containing protein H isoform 1", "refseq_ac": [ { "id": "NP_001298027", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001298027", "type": "external" } ], "gene_names_uniprotkb": "Iqch", "gene_names_refseq": "4921504K03Rik; Iqch", "protein_names_uniprotkb": "IQ domain-containing protein H", "protein_names_refseq": "IQ domain-containing protein H isoform 1; IQ domain-containing protein H", "tax_id": 10090, "disease": "", "pathway": " (mmu:78250)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15897968;21750661;31219806;34428180", "class_list": "", "function": "May play a regulatory role in spermatogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "G5E8B0;Q8C0X9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016607 nuclear speck", "go_biological_process": "GO:0007338 single fertilization;GO:0010467 gene expression;GO:0140742 lncRNA transcription", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9D2K4-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D312-1", "uniprot_id": [ { "id": "K1C20_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D312", "type": "external" } ], "mass": 49034.0, "length": 431, "protein_name": "Keratin, type I cytoskeletal 20", "gene_name": "Krt20", "organism": "Mouse", "refseq_name": "keratin, type I cytoskeletal 20", "refseq_ac": [ { "id": "NP_075745", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075745", "type": "external" } ], "gene_names_uniprotkb": "Krt20", "gene_names_refseq": "9030623C06Rik; Ck-20; Ck20; K20; Krt20; Krt21", "protein_names_uniprotkb": "Keratin, type I cytoskeletal 20; CK-20; Cytokeratin-20; K20; Keratin-20", "protein_names_refseq": "cytokeratin 20; keratin, type I cytoskeletal 20", "tax_id": 10090, "disease": "colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:66809); (R-MMU-6805567); (R-MMU-6809371)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "12857878;16608857;17242355;20724476;21183079;34428180;41018975", "class_list": "", "function": "K20 Ser(13) is a highly dynamic protein kinase C-related phosphorylation site that is induced during apoptosis and tissue injury, [RefSeq, PubMed]; Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine., [UniProtKB, PubMed, PubMed]; This gene encodes a member of the keratin protein family and is found within a cluster of cytokeratin genes on chromosome 11. Keratins are cytoskeletal proteins that are preferentially expressed in epithelial cells. The encoded protein may help maintain intermediate filament organization in intestinal epithelium. Phosphorylation of this protein may also influence mucin secretion in the small intestine. [provided by RefSeq, Dec 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PG82", "ec_number_list": [], "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0045111 intermediate filament cytoskeleton;GO:0045095 keratin filament", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0006915 apoptotic process;GO:0050708 regulation of protein secretion;GO:0009267 cellular response to starvation;GO:0045109 intermediate filament organization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9D312-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D498-1", "uniprot_id": [ { "id": "IQCF3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D498", "type": "external" } ], "mass": 23500.0, "length": 203, "protein_name": "IQ domain-containing protein F3", "gene_name": "Iqcf3", "organism": "Mouse", "refseq_name": "IQ domain-containing protein F3 isoform 2", "refseq_ac": [ { "id": "NP_080921", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080921", "type": "external" } ], "gene_names_uniprotkb": "Iqcf3", "gene_names_refseq": "1700012F17Rik; Iqcf3", "protein_names_uniprotkb": "IQ domain-containing protein F3; Testis-specific IQ motif-containing protein 2", "protein_names_refseq": "IQ domain-containing protein F3 isoform 2; IQ domain-containing protein F3; testis-specific IQ motif containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:68265)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D498-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D819-1", "uniprot_id": [ { "id": "IPYR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D819", "type": "external" } ], "mass": 32667.0, "length": 289, "protein_name": "Inorganic pyrophosphatase", "gene_name": "Ppa1", "organism": "Mouse", "refseq_name": "inorganic pyrophosphatase", "refseq_ac": [ { "id": "NP_080714", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080714", "type": "external" } ], "gene_names_uniprotkb": "Ppa1; Pp; Pyp", "gene_names_refseq": "2010317E03Rik; Ppa1; Pyp", "protein_names_uniprotkb": "Inorganic pyrophosphatase; 3.6.1.1; PPase; Pyrophosphate phospho-hydrolase", "protein_names_refseq": "PPase; inorganic pyrophosphatase; pyrophosphate phospho-hydrolase", "tax_id": 10090, "disease": "myocarditis (Disease Ontology:DOID:820)", "pathway": " (mmu:67895); (R-MMU-379716); (R-MMU-71737)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "22645316;23626709;24271717;24788674;25153642;28135057;28528544;33722839;34428180;37453647;37507081;37549601;37828378;38762596", "class_list": "", "function": "Catalyzes the hydrolysis of inorganic diphosphate into two phosphate molecules (PubMed:24271717). Has MAP kinase serine/threonine phosphatase activity toward c-Jun N-terminal kinase (JNK) and, in neuronal cells, is involved in the negative regulation of neurite growth via JNK dephosphorylation (PubMed:23626709)., [UniProtKB, PubMed, PubMed]; Cold-inducible PPA1 is critical for the adipocyte browning in mice., [RefSeq, PubMed]; PPA1 Regulates Systemic Insulin Sensitivity by Maintaining Adipocyte Mitochondria Function as a Novel PPARgamma Target Gene., [RefSeq, PubMed]; PPA1 promotes adipogenesis by regulating the stability of C/EBPs., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" } ], "go_molecular_function": "GO:0016462 pyrophosphatase activity;GO:0000287 magnesium ion binding;GO:0004427 inorganic diphosphate phosphatase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006796 phosphate-containing compound metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9D819-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DAL7-1", "uniprot_id": [ { "id": "IQCF5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DAL7", "type": "external" } ], "mass": 17809.0, "length": 148, "protein_name": "IQ domain-containing protein F5", "gene_name": "Iqcf5", "organism": "Mouse", "refseq_name": "IQ domain-containing protein F5", "refseq_ac": [ { "id": "NP_083576", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083576", "type": "external" } ], "gene_names_uniprotkb": "Iqcf5", "gene_names_refseq": "1700007L12Rik; Iqcf5", "protein_names_uniprotkb": "IQ domain-containing protein F5", "protein_names_refseq": "IQ domain-containing protein F5", "tax_id": 10090, "disease": "", "pathway": " (mmu:75470)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "31219806", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9DAL7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DCC7-1", "uniprot_id": [ { "id": "ISC2B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DCC7", "type": "external" } ], "mass": 23151.0, "length": 210, "protein_name": "Isochorismatase domain-containing protein 2B", "gene_name": "Isoc2b", "organism": "Mouse", "refseq_name": "isochorismatase domain-containing protein 2B", "refseq_ac": [ { "id": "NP_080434", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080434", "type": "external" } ], "gene_names_uniprotkb": "Isoc2b; Isoc2", "gene_names_refseq": "0610042E07Rik; Isoc2b; Isoc2", "protein_names_uniprotkb": "Isochorismatase domain-containing protein 2B", "protein_names_refseq": "isochorismatase domain-containing protein 2B, mitochondrial; isochorismatase domain-containing protein 2B", "tax_id": 10090, "disease": "", "pathway": " (mmu:67441)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17658461;23806337", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q80V19", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0031648 protein destabilization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9DCC7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ER75-1", "uniprot_id": [ { "id": "IRX6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ER75", "type": "external" } ], "mass": 47352.0, "length": 438, "protein_name": "Iroquois-class homeodomain protein IRX-6", "gene_name": "Irx6", "organism": "Mouse", "refseq_name": "iroquois-class homeodomain protein IRX-6 isoform 2", "refseq_ac": [ { "id": "NP_001288066", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001288066", "type": "external" } ], "gene_names_uniprotkb": "Irx6; Irxb3", "gene_names_refseq": "Irx6", "protein_names_uniprotkb": "Iroquois-class homeodomain protein IRX-6; Homeodomain protein IRXB3; Iroquois homeobox protein 6", "protein_names_refseq": "Iroquois related homeobox 6; homeodomain protein IRXB3; iroquois homeobox protein 6; iroquois-class homeodomain protein IRX-6 isoform 2; iroquois-class homeodomain protein IRX-6", "tax_id": 10090, "disease": "", "pathway": " (mmu:64379)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11042145;11335133;23172916;25428506;29187734", "class_list": "", "function": "Transcription factor (PubMed:23172916). Binds to the iroquois binding site (IBS) motif of target genes to regulate gene expression; functions as a transcriptional activator or repressor (PubMed:23172916). Modulates expression of RCVRN, VSX1, BHLHE22/BHLHB5 and TACR3/Nk3r (PubMed:23172916). Required downstream of retinal bipolar cell specification for the terminal differentiation of type 2, type 3a and possibly type 6 bipolar cells (PubMed:23172916)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A1L3D2;E9Q2V2", "ec_number_list": [], "go_molecular_function": "GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0009584 detection of visible light;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9ER75-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JIN6-1", "uniprot_id": [ { "id": "KCMB4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JIN6", "type": "external" } ], "mass": 23857.0, "length": 210, "protein_name": "Calcium-activated potassium channel subunit beta-4", "gene_name": "Kcnmb4", "organism": "Mouse", "refseq_name": "calcium-activated potassium channel subunit beta-4 isoform 1", "refseq_ac": [ { "id": "NP_067427", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067427", "type": "external" } ], "gene_names_uniprotkb": "Kcnmb4", "gene_names_refseq": "1700058G18Rik; 2900045G12Rik; BKbeta4; Kcnmb4; k(VCA)beta-4; slo-beta-4", "protein_names_uniprotkb": "Calcium-activated potassium channel subunit beta-4; BK channel subunit beta-4; BKbeta4; Calcium-activated potassium channel, subfamily M subunit beta-4; Charybdotoxin receptor subunit beta-4; K(VCA)beta-4; Maxi K channel subunit beta-4; Slo-beta-4", "protein_names_refseq": "BK channel subunit beta-4; Slowpoke beta 4; calcium-activated potassium channel subunit beta-4 isoform 1; calcium-activated potassium channel subunit beta-4; calcium-activated potassium channel, subfamily M subunit beta-4; charybdotoxin receptor subunit beta-4; large conductance calcium-dependent potassium ion channel beta 4 subunit; maxi K channel subunit beta-4", "tax_id": 10090, "disease": "", "pathway": " (mmu:58802); (R-MMU-1296052)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;10804197;25561520", "class_list": "", "function": "Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q149I1", "ec_number_list": [], "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0005267 potassium channel activity;GO:0015269 calcium-activated potassium channel activity;GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential", "go_cellular_component": "GO:0005886 plasma membrane;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:0019228 neuronal action potential;GO:0001508 action potential;GO:0006813 potassium ion transport;GO:0005513 detection of calcium ion", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9JIN6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0H5-1", "uniprot_id": [ { "id": "K2C71_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R0H5", "type": "external" } ], "mass": 57383.0, "length": 524, "protein_name": "Keratin, type II cytoskeletal 71", "gene_name": "Krt71", "organism": "Mouse", "refseq_name": "keratin, type II cytoskeletal 71", "refseq_ac": [ { "id": "NP_064340", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064340", "type": "external" } ], "gene_names_uniprotkb": "Krt71; K6irs1; Kb34; Krt2-6g; Krt6g", "gene_names_refseq": "CK-6G; CK-71; Cal4; Ca; Cu; K6G; K71; Krt2-6g; Krt71; mK6irs1; mK6irs", "protein_names_uniprotkb": "Keratin, type II cytoskeletal 71; CK-6G; CK-71; Cytokeratin-6G; Cytokeratin-71; K6G; K71; Keratin-6G; Keratin-71; Type II inner root sheath-specific keratin-K6irs1; Type-II keratin Kb34; mK6irs1/Krt2-6g; mK6irs", "protein_names_refseq": "caracul; cytokeratin-6G; cytokeratin-71; keratin complex 2, basic, gene 6g; keratin complex 2, gene 6g; keratin, type II cytoskeletal 71; keratin-6G; mK6irs1/Krt2-6g; type II inner root sheath-specific keratin-K6irs1; type-II keratin Kb34", "tax_id": 10090, "disease": "hypotrichosis 13 (Disease Ontology:DOID:0110710); alopecia (Disease Ontology:DOID:987)", "pathway": " (mmu:56735); (R-MMU-6805567); (R-MMU-6809371)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "11231308;11703281;14573483;14632181;17143583;23817565;27669760;28011936;32069316;32152506;34428180;35820727;36583994", "class_list": "", "function": "Plays a central role in hair formation. Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0JLW9;Q7TPF3;Q9D0X6", "ec_number_list": [], "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0045095 keratin filament", "go_biological_process": "GO:0031424 keratinization;GO:0045109 intermediate filament organization;GO:0031069 hair follicle morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9R0H5-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0Y7-1", "uniprot_id": [ { "id": "IRS4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z0Y7", "type": "external" } ], "mass": 130147.0, "length": 1216, "protein_name": "Insulin receptor substrate 4", "gene_name": "Irs4", "organism": "Mouse", "refseq_name": "insulin receptor substrate 4", "refseq_ac": [ { "id": "NP_034702", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034702", "type": "external" } ], "gene_names_uniprotkb": "Irs4", "gene_names_refseq": "IRS-4; Irs4", "protein_names_uniprotkb": "Insulin receptor substrate 4; IRS-4; Phosphoprotein of 160 kDa; pp160", "protein_names_refseq": "insulin receptor substrate 4; phosphoprotein of 160 kDa; pp160", "tax_id": 10090, "disease": "congenital nongoitrous hypothyroidism 9 (Disease Ontology:DOID:0111835); intellectual disability (Disease Ontology:DOID:1059); amnestic disorder (Disease Ontology:DOID:10914); lung cancer (Disease Ontology:DOID:1324); lung non-small cell carcinoma (Disease Ontology:DOID:3908); glucose metabolism disease (Disease Ontology:DOID:4194); colorectal cancer (Disease Ontology:DOID:9256); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:16370); (R-MMU-2428928)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10067860;10403832;10644546;11113178;11788580;12052866;12618213", "class_list": "", "function": "Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; These data suggest that IRS-dependent signaling pathways work by recruiting different signaling molecules to determine specificity of IL-2R gamma superfamily cytokines., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2BHF6;Q8BRB9", "ec_number_list": [], "go_molecular_function": "GO:0005158 insulin receptor binding;GO:0043548 phosphatidylinositol 3-kinase binding;GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity;GO:0141038 phosphatidylinositol 3-kinase activator activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0010631 epithelial cell migration;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0008286 insulin receptor signaling pathway;GO:0010634 positive regulation of epithelial cell migration", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9Z0Y7-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1Y9-1", "uniprot_id": [ { "id": "IOD2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z1Y9", "type": "external" } ], "mass": 29929.0, "length": 266, "protein_name": "Type II iodothyronine deiodinase", "gene_name": "Dio2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Dio2", "gene_names_refseq": "", "protein_names_uniprotkb": "Type II iodothyronine deiodinase; 1.21.99.4; 5DII; DIOII; Type 2 DI; Type-II 5'-deiodinase", "protein_names_refseq": "", "tax_id": 10090, "disease": "hypertension (Disease Ontology:DOID:10763); hypothyroidism (Disease Ontology:DOID:1459); glucose metabolism disease (Disease Ontology:DOID:4194)", "pathway": " (mmu:13371); (R-MMU-350864)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10655523;10715551;21750661;9927339", "class_list": "", "function": "Plays a crucial role in the metabolism of thyroid hormones (TH) and has specific roles in TH activation and inactivation by deiodination (PubMed:10715551). Catalyzes the deiodination of L-thyroxine (T4) to 3,5,3'-triiodothyronine (T3) and 3,3',5'-triiodothyronine (rT3) to 3,3'-diiodothyronine (3,3'-T2) via outer-ring deiodination (ORD) (PubMed:10715551). Catalyzes the deiodination of 3',5'-diiodothyronine (3',5'-T2) to 3'-monoiodothyronine (3'-T1) via ORD (By similarity). Catalyzes the phenolic ring deiodinations of 3,3',5'-triiodothyronamine and 3',5'- diiodothyronamine (By similarity)., [UniProtKB, UniProtKB, PubMed]; Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q05A70;Q9JHH1", "ec_number_list": [ { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "1.21.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.21.99.3", "type": "external" }, { "id": "1.21.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.21.99.4", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" } ], "go_molecular_function": "GO:0033798 thyroxine 5-deiodinase activity;GO:0031625 ubiquitin protein ligase binding;GO:0004800 thyroxine 5'-deiodinase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0042404 thyroid hormone catabolic process;GO:0006629 lipid metabolic process;GO:0050873 brown fat cell differentiation;GO:0042446 hormone biosynthetic process;GO:0006590 thyroid hormone generation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9Z1Y9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z331-1", "uniprot_id": [ { "id": "K2C6B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z331", "type": "external" } ], "mass": 60322.0, "length": 562, "protein_name": "Keratin, type II cytoskeletal 6B", "gene_name": "Krt6b", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Krt6b; K6-beta; Krt2-6b", "gene_names_refseq": "", "protein_names_uniprotkb": "Keratin, type II cytoskeletal 6B; CK-6B; Cytokeratin-6B; K6B; Keratin-6-beta; Keratin-6B; mK6-beta", "protein_names_refseq": "", "tax_id": 10090, "disease": "pachyonychia congenita (Disease Ontology:DOID:0050449); focal or diffuse nonepidermolytic palmoplantar keratoderma (Disease Ontology:DOID:0111710)", "pathway": " (R-MMU-6805567); (R-MMU-6809371)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "30389720;34428180;36288343;8636216;9790766", "class_list": "", "function": "Structural component of intermediate filaments in epithelial keratinocytes. Forms heteropolymers with the type I keratins KRT16 and KRT17, assembling keratin intermediate filament networks that contributes to the structural integrity and stress resilience of stratified epithelia and appendages (By similarity). Induced during epidermal stress and wound repair, where it regulates keratinocyte migration and epithelial regeneration (PubMed:30389720). Negatively regulates collective keratinocyte migration by stabilizing non-muscle myosin MYH9 and desmoplakin, thereby altering cell-cell and cell-matrix adhesion and reducing the speed and directionality of epithelial sheet movement during wound repair (PubMed:30389720). Required for normal palmoplantar, nail unit and oral mucosa integrity (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0045111 intermediate filament cytoskeleton;GO:0045095 keratin filament", "go_biological_process": "GO:0031424 keratinization;GO:0045109 intermediate filament organization;GO:0002009 morphogenesis of an epithelium", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9Z331-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U821-1", "uniprot_id": [ { "id": "WDR75_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U821", "type": "external" } ], "mass": 94037.0, "length": 830, "protein_name": "WD repeat-containing protein 75", "gene_name": "Wdr75", "organism": "Mouse", "refseq_name": "WD repeat-containing protein 75", "refseq_ac": [ { "id": "NP_082875", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082875", "type": "external" } ], "gene_names_uniprotkb": "Wdr75; Utp17", "gene_names_refseq": "1300003A18Rik; 2410118I19Rik; Wdr75", "protein_names_uniprotkb": "WD repeat-containing protein 75; U3 small nucleolar RNA-associated protein 17 homolog", "protein_names_refseq": "U3 small nucleolar RNA-associated protein 17 homolog; WD repeat-containing protein 75", "tax_id": 10090, "disease": "lissencephaly (Disease Ontology:DOID:0050453); autism spectrum disorder (Disease Ontology:DOID:0060041); subcortical band heterotopia (Disease Ontology:DOID:0111169)", "pathway": " (mmu:73674); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "17242355;21183079;21750661;25428506;31599954;34428180", "class_list": "", "function": "Ribosome biogenesis factor. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q08EC1", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0032040 small-subunit processome", "go_biological_process": "GO:2000234 positive regulation of rRNA processing;GO:0006351 DNA-templated transcription;GO:0006364 rRNA processing;GO:0045943 positive regulation of transcription by RNA polymerase I;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3U821-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91XE7-1", "uniprot_id": [ { "id": "VA0E2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91XE7", "type": "external" } ], "mass": 9198.0, "length": 81, "protein_name": "V-type proton ATPase subunit e 2", "gene_name": "Atp6v0e2", "organism": "Mouse", "refseq_name": "V-type proton ATPase subunit e 2 isoform 1", "refseq_ac": [ { "id": "NP_598525", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598525", "type": "external" } ], "gene_names_uniprotkb": "Atp6v0e2", "gene_names_refseq": "0610006O14Rik; Atp6v0e2; NM9.2", "protein_names_uniprotkb": "V-type proton ATPase subunit e 2; V-ATPase subunit e 2; Vacuolar proton pump subunit e 2", "protein_names_refseq": "ATPase, H+ transporting, lysosomal, V0 subunit E; V-ATPase subunit e 2; V-type proton ATPase subunit e 2 isoform 1; V-type proton ATPase subunit e 2; vacuolar proton pump subunit e 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:76252); (R-MMU-1222556); (R-MMU-77387); (R-MMU-917977); (R-MMU-9639288); (R-MMU-983712)", "pathway_count": 6, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;12544825;21750661", "class_list": "", "function": "A cDNA encoding a novel putative neuron-specific isoform of vacuolar proton-translocating ATPase (V-ATPase), NM9.2, was isolated from rat and mouse, [RefSeq, PubMed]; Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0030665 clathrin-coated vesicle membrane;GO:0030672 synaptic vesicle membrane;GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain;GO:0033179 proton-transporting V-type ATPase, V0 domain", "go_biological_process": "GO:0097401 synaptic vesicle lumen acidification;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q91XE7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32648-1", "uniprot_id": [ { "id": "VIP_MOUSE", "url": "https://www.uniprot.org/uniprot/P32648", "type": "external" } ], "mass": 19049.0, "length": 170, "protein_name": "VIP peptides", "gene_name": "Vip", "organism": "Mouse", "refseq_name": "VIP peptides isoform 2 preproprotein", "refseq_ac": [ { "id": "NP_001300898", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001300898", "type": "external" } ], "gene_names_uniprotkb": "Vip", "gene_names_refseq": "Vip", "protein_names_uniprotkb": "VIP peptides; Peptide histidine isoleucinamide 27; Vasoactive intestinal polypeptide", "protein_names_refseq": "PHI, peptide histidine isoleucine; VIP peptides isoform 2 preproprotein; VIP peptides", "tax_id": 10090, "disease": "Parkinsonism (Disease Ontology:DOID:0080855); uveitis (Disease Ontology:DOID:13141); pulmonary sarcoidosis (Disease Ontology:DOID:13406); Parkinson's disease (Disease Ontology:DOID:14330); primary pulmonary hypertension (Disease Ontology:DOID:14557); alcohol use disorder (Disease Ontology:DOID:1574); brain ischemia (Disease Ontology:DOID:2316); asthma (Disease Ontology:DOID:2841); endometriosis (Disease Ontology:DOID:289); pulmonary hypertension (Disease Ontology:DOID:6432); ankylosing spondylitis (Disease Ontology:DOID:7147); periodontitis (Disease Ontology:DOID:824); ulcerative colitis (Disease Ontology:DOID:8577)", "pathway": " (mmu:22353); (R-MMU-418555); (R-MMU-420092)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "1851524;21750661;7894056;8402943", "class_list": "", "function": "Bioactive forms that cause vasodilation., [UniProtKB, UniProtKB]; Bioactive forms that cause vasodilation. PHM-27 is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin., [UniProtKB, UniProtKB]; This gene encodes a neuropeptide of the glucagon/secretin superfamily with potent bronchodilator, immunomodulator and anti-inflammatory properties. The encoded protein is proteolytically processed to generate two structurally similar neuropeptides - vasoactive intestinal peptide (VIP) and peptide histidine isoleucine (PHI). In the digestive tract, VIP stimulates relaxation of enteric smooth muscle, secretion of water and electrolytes, release of insulin and glucagon, and inhibition of gastric acid secretion. In the cardiovascular system, VIP causes coronary vasodilation and stimulates contractility in the heart. Mice lacking VIP exhibit airway hyperresponsiveness and airway inflammation. Male mice lacking VIP exhibit moderate pulmonary arterial hypertension resulting in increased mortality. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]., [RefSeq]; VIP is a neuropeptide involved in a diverse array of physiological processes through activating the PACAP subfamily of class B1 G protein-coupled receptors: VIP receptor 1 (VPR1) and VIP receptor 2 (VPR2). Abundantly expressed throughout the CNS and peripheral nervous systems where they primarily exert neuroprotective and immune modulatory roles (By similarity). Also causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9D2Z7;Q9QUN1", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005184 neuropeptide hormone activity;GO:0005179 hormone activity;GO:0051428 peptide hormone receptor binding;GO:0031891 type 1 vasoactive intestinal polypeptide receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0043025 neuronal cell body;GO:0043005 neuron projection", "go_biological_process": "GO:0048242 epinephrine secretion;GO:0060406 positive regulation of penile erection;GO:0001878 response to yeast;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007611 learning or memory", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P32648-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQ51-1", "uniprot_id": [ { "id": "V1R47_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EQ51", "type": "external" } ], "mass": 35433.0, "length": 310, "protein_name": "Vomeronasal type-1 receptor 47", "gene_name": "Vmn1r47", "organism": "Mouse", "refseq_name": "vomeronasal type-1 receptor 47", "refseq_ac": [ { "id": "NP_444449", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444449", "type": "external" } ], "gene_names_uniprotkb": "Vmn1r47; V1ra4; V1ra7", "gene_names_refseq": "V1RA7; V1ra4; Vmn1r47", "protein_names_uniprotkb": "Vomeronasal type-1 receptor 47; Vomeronasal type-1 receptor A4; Vomeronasal type-1 receptor A7", "protein_names_refseq": "vomernasal 1 receptor Vmn1r47; vomeronasal 1 receptor, A4; vomeronasal receptor 1 A7; vomeronasal type-1 receptor 47; vomeronasal type-1 receptor A4; vomeronasal type-1 receptor A7", "tax_id": 10090, "disease": "", "pathway": " (mmu:113846)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11116090;12214233;21750661", "class_list": "", "function": "Putative pheromone receptor implicated in the regulation of social and reproductive behavior., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q2M2P9;Q8VIC8", "ec_number_list": [], "go_molecular_function": "GO:0005550 pheromone binding;GO:0016503 pheromone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9EQ51-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYC7-1", "uniprot_id": [ { "id": "VKGC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QYC7", "type": "external" } ], "mass": 87195.0, "length": 757, "protein_name": "Vitamin K-dependent gamma-carboxylase", "gene_name": "Ggcx", "organism": "Mouse", "refseq_name": "vitamin K-dependent gamma-carboxylase isoform 1", "refseq_ac": [ { "id": "NP_062776", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062776", "type": "external" } ], "gene_names_uniprotkb": "Ggcx", "gene_names_refseq": "Ggcx; VKGC", "protein_names_uniprotkb": "Vitamin K-dependent gamma-carboxylase; 4.1.1.90; Gamma-glutamyl carboxylase; Peptidyl-glutamate 4-carboxylase; VKGC; Vitamin K gamma glutamyl carboxylase", "protein_names_refseq": "peptidyl-glutamate 4-carboxylase; vitamin K gamma glutamyl carboxylase; vitamin K-dependent gamma-carboxylase isoform 1; vitamin K-dependent gamma-carboxylase", "tax_id": 10090, "disease": "urolithiasis (Disease Ontology:DOID:0080653); combined deficiency of vitamin K-dependent clotting factors 1 (Disease Ontology:DOID:0112173)", "pathway": " (mmu:56316); (R-MMU-159740)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;17327402;20173027;21750661;25264202;29237092;30084848;31599954;34428180;37453647;40997131", "class_list": "", "function": "Analysis of a Ggcx(+/-) intercross revealed a partial developmental block with only 50% of expected Ggcx(-/-) offspring surviving to term, with the latter animals dying uniformly at birth of massive intra-abdominal hemorrhage, [RefSeq, PubMed]; Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant epoxidation of vitamin K hydroquinone to vitamin K epoxide (By similarity). Couples epoxidation and carboxylation in the same active site (By similarity). Catalyzes gamma-carboxylation of blood coagulation factors (F2, F7, F9 and F10) and anticoagulants such as PROC, which are essential for thrombosis (By similarity). Catalyzes gamma-carboxylation of osteocalcin/BGLAP, which is essential for bone metabolism (PubMed:25264202). Catalyzes gamma-carboxylation of matrix Gla protein (MGP) and other transmembrane gamma-Gla proteins such as PRRG2, which are essential for calcium homeostasis and haemostasis (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3UXN5;Q8CCB3", "ec_number_list": [ { "id": "3.4.21.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.6", "type": "external" }, { "id": "3.4.21.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.22", "type": "external" }, { "id": "3.4.21.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.5", "type": "external" }, { "id": "3.4.21.69", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.69", "type": "external" }, { "id": "3.4.21.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.21", "type": "external" }, { "id": "4.1.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.90", "type": "external" } ], "go_molecular_function": "GO:0019842 vitamin binding;GO:0008289 lipid binding;GO:0008488 gamma-glutamyl carboxylase activity", "go_cellular_component": "GO:0005788 endoplasmic reticulum lumen;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:1903011 negative regulation of bone development;GO:0046929 negative regulation of neurotransmitter secretion;GO:0051604 protein maturation;GO:0017187 peptidyl-glutamic acid carboxylation;GO:2000225 negative regulation of testosterone biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9QYC7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K245-1", "uniprot_id": [ { "id": "UVRAG_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K245", "type": "external" } ], "mass": 77525.0, "length": 698, "protein_name": "UV radiation resistance-associated protein", "gene_name": "Uvrag", "organism": "Mouse", "refseq_name": "UV radiation resistance-associated protein", "refseq_ac": [ { "id": "NP_848750", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848750", "type": "external" } ], "gene_names_uniprotkb": "Uvrag; Uvrag1", "gene_names_refseq": "9530039D02Rik; Uvrag1; Uvragl; Uvrag", "protein_names_uniprotkb": "UV radiation resistance-associated protein", "protein_names_refseq": "UV radiation resistance associated protein; UV radiation resistance-associated gene protein; UV radiation resistance-associated protein", "tax_id": 10090, "disease": "colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:78610); (R-MMU-1632852)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "17242355;17891140;19144319;21183079;21750661;22493499;31831743;31905312;33561544;34428180", "class_list": "", "function": "Distinct roles of UVRAG and EGFR signaling in skeletal muscle homeostasis., [RefSeq, PubMed]; Involved in maintaining chromosomal stability. Promotes DNA double-strand break (DSB) repair by association with DNA-dependent protein kinase complex DNA-PK and activating it in non-homologous end joining (NHEJ). Required for centrosome stability and proper chromosome segregation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Through ultraviolet irradiation resistance-associated gene (UVRAG), Bif-1 interacts with Beclin 1 and functions as a positive mediator of the class III PI(3) kinase (PI(3)KC3)., [RefSeq, PubMed]; UVRAG in autophagy, inflammation, and cancer., [RefSeq, PubMed]; UVRAG is a crucial autophagy regulator in vivo, and autophagy promotion may help prevent/treat inflammatory disease and cancer in susceptible individuals. Publication Status: Online-Only, [RefSeq, PubMed]; Versatile protein that is involved in regulation of different cellular pathways implicated in membrane trafficking. Involved in regulation of the COPI-dependent retrograde transport from Golgi and the endoplasmic reticulum by associating with the NRZ complex; the function is dependent on its binding to phosphatidylinositol 3-phosphate (PtdIns(3)P). During autophagy acts as a regulatory subunit of the alternative PI3K complex II (PI3KC3-C2) that mediates formation of phosphatidylinositol 3-phosphate and is believed to be involved in maturation of autophagosomes and endocytosis. Activates lipid kinase activity of PIK3C3. Involved in the regulation of degradative endocytic trafficking and cytokinesis, and in regulation of ATG9A transport from the Golgi to the autophagosome; the functions seems to implicate its association with PI3KC3-C2. Involved in maturation of autophagosomes and degradative endocytic trafficking independently of BECN1 but depending on its association with a class C Vps complex (possibly the HOPS complex); the association is also proposed to promote autophagosome recruitment and activation of Rab7 and endosome-endosome fusion events. Enhances class C Vps complex (possibly HOPS complex) association with a SNARE complex and promotes fusogenic SNARE complex formation during late endocytic membrane fusion. In case of negative-strand RNA virus infection is required for efficient virus entry, promotes endocytic transport of virions and is implicated in a VAMP8-specific fusogenic SNARE complex assembly., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BVI8;Q8C0K8", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0000149 SNARE binding", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005768 endosome;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0005813 centrosome", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0097680 double-strand break repair via classical nonhomologous end joining;GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process;GO:0051684 maintenance of Golgi location;GO:0006281 DNA repair", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8K245-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R2N2-1", "uniprot_id": [ { "id": "UTP4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R2N2", "type": "external" } ], "mass": 76909.0, "length": 686, "protein_name": "U3 small nucleolar RNA-associated protein 4 homolog", "gene_name": "Utp4", "organism": "Mouse", "refseq_name": "U3 small nucleolar RNA-associated protein 4 homolog", "refseq_ac": [ { "id": "NP_035704", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035704", "type": "external" } ], "gene_names_uniprotkb": "Utp4; Cirh1a; Kiaa1988; Tex292", "gene_names_refseq": "Cirh1a; Cirhin; Naic; Teg-292; Tex292; Utp4", "protein_names_uniprotkb": "U3 small nucleolar RNA-associated protein 4 homolog; Cirhin; Testis-expressed gene 292 protein", "protein_names_refseq": "U3 small nucleolar RNA-associated protein 4 homolog; cirrhosis, autosomal recessive 1A; testis-expressed gene 292 protein", "tax_id": 10090, "disease": "primary biliary cholangitis (Disease Ontology:DOID:12236); cholestasis (Disease Ontology:DOID:13580); liver cirrhosis (Disease Ontology:DOID:5082)", "pathway": " (mmu:21771); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "12417987;21750661;25605945;31219806;34428180;8703127", "class_list": "", "function": "Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted d Involved in SSU pre-rRNA processing at sites A', A0, 1 and 2b. Required for optimal pre-ribosomal RNA transcription by RNA polymerase. May be a transcriptional regulator., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q62306;Q62307;Q69Z48;Q6NVG9;Q8VEL5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus;GO:0001650 fibrillar center;GO:0005694 chromosome;GO:0034455 t-UTP complex;GO:0030686 90S preribosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0042274 ribosomal small subunit biogenesis;GO:0030490 maturation of SSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8R2N2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80WQ2-1", "uniprot_id": [ { "id": "VAC14_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80WQ2", "type": "external" } ], "mass": 88048.0, "length": 782, "protein_name": "Protein VAC14 homolog", "gene_name": "Vac14", "organism": "Mouse", "refseq_name": "protein VAC14 homolog", "refseq_ac": [ { "id": "NP_666328", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666328", "type": "external" } ], "gene_names_uniprotkb": "Vac14; D8Wsu151e", "gene_names_refseq": "D8Wsu151e; Tax1bp2; Trx; Vac14; ingls", "protein_names_uniprotkb": "Protein VAC14 homolog", "protein_names_refseq": "Tax1 (human T-cell leukemia virus type I) binding protein 1; Tax1 (human T-cell leukemia virus type I) binding protein 2; protein VAC14 homolog; vacuole morphology 14", "tax_id": 10090, "disease": "striatonigral degeneration (Disease Ontology:DOID:4751)", "pathway": " (mmu:234729); (R-MMU-1660514); (R-MMU-1660516); (R-MMU-1660517)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "11889142;17475247;17956977;19037259;21750661;25605945;26740625;31219806;32782141;33300544;34428180;37363915", "class_list": "", "function": "Report the characterization of a mouse mutant lacking Vac14, a regulator of PI(3,5)P(2) synthesis, [RefSeq, PubMed]; Scaffold protein component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Pentamerizes into a star-shaped structure and nucleates the assembly of the complex. The pentamer binds a single copy each of PIKFYVE and FIG4 and coordinates both PIKfyve kinase activity and FIG4 phosphatase activity, being required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; The authors show that Vac14 exerts an effect as a scaffold for the PI(3,5)P2 regulatory complex by direct contact with the known regulators of PI(3,5)P2: Fig4, Fab1, Vac7 and Atg18., [RefSeq, PubMed]; The chloride antiporter CLCN7 is a modifier of lysosome dysfunction in FIG4 and VAC14 mutants. Publication Status: Online-Only, [RefSeq, PubMed]; The data demonstrate for the first time a physical association between functionally related PIKfyve and ArPIKfyve in 3T3-L1 adipocytes., [RefSeq, PubMed]; This publication pertains to studies in yeast., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TAX7;Q8C8K8", "ec_number_list": [], "go_molecular_function": "GO:0019209 kinase activator activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005829 cytosol;GO:0010008 endosome membrane;GO:0005774 vacuolar membrane;GO:0098830 presynaptic endosome;GO:0070772 PAS complex", "go_biological_process": "GO:0006970 response to osmotic stress;GO:0006661 phosphatidylinositol biosynthetic process;GO:0099149 regulation of postsynaptic neurotransmitter receptor internalization;GO:1903100 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q80WQ2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BFQ4-1", "uniprot_id": [ { "id": "WDR82_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BFQ4", "type": "external" } ], "mass": 35079.0, "length": 313, "protein_name": "WD repeat-containing protein 82", "gene_name": "Wdr82", "organism": "Mouse", "refseq_name": "WD repeat-containing protein 82", "refseq_ac": [ { "id": "NP_084172", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084172", "type": "external" } ], "gene_names_uniprotkb": "Wdr82; Cdw5", "gene_names_refseq": "9430077D24Rik; CDW5/WDR82; Wdr82", "protein_names_uniprotkb": "WD repeat-containing protein 82", "protein_names_refseq": "WD repeat-containing protein 82", "tax_id": 10090, "disease": "congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (mmu:77305); (R-MMU-9772755); (R-MMU-9930044)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "17041588;21123813;21750661;25428506;29187734;31219806;31599954;33767452;34428180;37470863", "class_list": "", "function": "Regulatory component of the SET1/COMPASS complex implicated in the tethering of this complex to transcriptional start sites of active genes (By similarity). Facilitates histone H3 'Lys-4' methylation (H3K4me) via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A) (By similarity). Component of the PNUTS-PP1 protein phosphatase complex, a protein phosphatase 1 (PP1) complex that promotes RNA polymerase II transcription pause-release, allowing transcription elongation (By similarity). PNUTS-PP1 also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (By similarity). Together with ZC3H4, but independently of the SET1 complex, part of a transcription termination checkpoint that promotes transcription termination of long non-coding RNAs (lncRNAs) (PubMed:33767452). The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs and promotes transcription termination of lncRNAs and their subsequent degradation by the exosome (PubMed:33767452)., [UniProtKB, PubMed, UniProtKB]; The result of a blocked WDR82 consists of stunted embryonic development and death. Thus, WDR82 can be considered a key epigenetic regulation-related factor crucial in the normal growth and development of embryos., [RefSeq, PubMed]; WD repeat domain 82 (Wdr82) facilitates mouse iPSCs generation by interfering mitochondrial oxidative phosphorylation and glycolysis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K2G5;Q8VEE8", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0106222 lncRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0000785 chromatin;GO:0035097 histone methyltransferase complex;GO:0048188 Set1C/COMPASS complex", "go_biological_process": "GO:0032785 negative regulation of DNA-templated transcription, elongation;GO:0006353 DNA-templated transcription termination;GO:0010467 gene expression;GO:0001111 RNA polymerase II promoter clearance;GO:0032968 positive regulation of transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8BFQ4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PDS0-1", "uniprot_id": [ { "id": "VTM2L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PDS0", "type": "external" } ], "mass": 23723.0, "length": 220, "protein_name": "V-set and transmembrane domain-containing protein 2-like protein", "gene_name": "Vstm2l", "organism": "Mouse", "refseq_name": "V-set and transmembrane domain-containing protein 2-like protein precursor", "refseq_ac": [ { "id": "NP_941029", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_941029", "type": "external" } ], "gene_names_uniprotkb": "Vstm2l; Gm691", "gene_names_refseq": "Gm691; Vstm2l", "protein_names_uniprotkb": "V-set and transmembrane domain-containing protein 2-like protein", "protein_names_refseq": "V-set and transmembrane domain-containing protein 2-like protein precursor; V-set and transmembrane domain-containing protein 2-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:277432)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0043524 negative regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6PDS0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80ZK9-1", "uniprot_id": [ { "id": "WDTC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80ZK9", "type": "external" } ], "mass": 75733.0, "length": 677, "protein_name": "WD and tetratricopeptide repeats protein 1", "gene_name": "Wdtc1", "organism": "Mouse", "refseq_name": "WD and tetratricopeptide repeats protein 1 isoform 1", "refseq_ac": [ { "id": "NP_955010", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955010", "type": "external" } ], "gene_names_uniprotkb": "Wdtc1; Gm695", "gene_names_refseq": "Gm695; Wdtc1; adipose; adp", "protein_names_uniprotkb": "WD and tetratricopeptide repeats protein 1", "protein_names_refseq": "WD and tetratricopeptide repeats protein 1 isoform 1; WD and tetratricopeptide repeats protein 1", "tax_id": 10090, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:230796); (R-MMU-8951664)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;17242355;17767906;21183079;21750661;25088174;25428506;28135057;30084848;34428180;37980532", "class_list": "", "function": "Adp is a positive modulator of myoblast differentiation., [RefSeq, PubMed]; Data show that the anti-obesity function of adipose (Adp) (worm Y73E7A.9, fly adp, and murine Wdtc1) is conserved from worms to mammals., [RefSeq, PubMed]; ELF5 drives angiogenesis suppression though stabilizing WDTC1 in renal cell carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004857 enzyme inhibitor activity;GO:0042826 histone deacetylase binding;GO:0042393 histone binding", "go_cellular_component": "GO:0031464 Cul4A-RING E3 ubiquitin ligase complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031465 Cul4B-RING E3 ubiquitin ligase complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0032869 cellular response to insulin stimulus;GO:0045717 negative regulation of fatty acid biosynthetic process;GO:0035264 multicellular organism growth", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q80ZK9-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80SY3-1", "uniprot_id": [ { "id": "VA0D2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80SY3", "type": "external" } ], "mass": 40494.0, "length": 350, "protein_name": "V-type proton ATPase subunit d 2", "gene_name": "Atp6v0d2", "organism": "Mouse", "refseq_name": "V-type proton ATPase subunit d 2", "refseq_ac": [ { "id": "NP_780615", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780615", "type": "external" } ], "gene_names_uniprotkb": "Atp6v0d2", "gene_names_refseq": "1620401A02Rik; Atp6v0d2; V-ATPase", "protein_names_uniprotkb": "V-type proton ATPase subunit d 2; Osteoclast-specific vacuolar ATP synthase; V-ATPase subunit d 2; Vacuolar proton pump subunit d 2", "protein_names_refseq": "V-ATPase subunit d 2; V-type proton ATPase subunit d 2; osteoclast-specific vacuolar ATP synthase; vacuolar proton pump subunit d 2; vacuolar proton-translocating ATPase d subunit d2", "tax_id": 10090, "disease": "", "pathway": " (mmu:242341); (R-MMU-1222556); (R-MMU-77387); (R-MMU-917977); (R-MMU-9639288); (R-MMU-983712)", "pathway_count": 6, "publication_count": 13, "publication_id_list": "12527205;12963731;17128270;21750661;30084848;30779550;34428180;35820727;37494443;38265287;38357442;38422177;38555350", "class_list": "", "function": "D2 is expressed mainly in kidney and at lower levels in heart, spleen, skeletal muscle, and testis. The d2 isoform can complement the yeast vma6Delta phenotype when cells are grown at 25, but not 30, degrees C., [RefSeq, PubMed]; Glycolysis-Mediated Activation of v-ATPase by Nicotinamide Mononucleotide Ameliorates Lipid-Induced Cardiomyopathy by Repressing the CD36-TLR4 Axis., [RefSeq, PubMed]; Loss of the Golgi-localized v-ATPase subunit does not alter insulin granule formation or pancreatic islet beta-cell function., [RefSeq, PubMed]; Lysosomal dysfunction in Down syndrome and Alzheimer mouse models is caused by v-ATPase inhibition by Tyr[682]-phosphorylated APP betaCTF., [RefSeq, PubMed]; Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). May play a role in coupling of proton transport and ATP hydrolysis (PubMed:12963731). Regulator of osteoclast fusion and bone formation (PubMed:17128270)., [UniProtKB, PubMed, UniProtKB, PubMed]; Upregulation of ATP6V0D2 benefits intracellular survival of Leishmania donovani in erythrocytes-engulfing macrophages. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TDQ6;Q5I0V5;Q8BTL3;Q8BW16", "ec_number_list": [], "go_molecular_function": "GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0005768 endosome;GO:0005769 early endosome;GO:0016020 membrane;GO:0016324 apical plasma membrane;GO:0016471 vacuolar proton-transporting V-type ATPase complex", "go_biological_process": "GO:0007034 vacuolar transport;GO:0007035 vacuolar acidification", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q80SY3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B7ZMP1-1", "uniprot_id": [ { "id": "XPP3_MOUSE", "url": "https://www.uniprot.org/uniprot/B7ZMP1", "type": "external" } ], "mass": 56677.0, "length": 506, "protein_name": "Xaa-Pro aminopeptidase 3", "gene_name": "Xpnpep3", "organism": "Mouse", "refseq_name": "xaa-Pro aminopeptidase 3 isoform 2", "refseq_ac": [ { "id": "NP_001334004", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334004", "type": "external" } ], "gene_names_uniprotkb": "Xpnpep3", "gene_names_refseq": "APP3; E430012M05Rik; Xpnpep3", "protein_names_uniprotkb": "Xaa-Pro aminopeptidase 3; 3.4.11.9; APP3; Aminopeptidase P3; X-Pro aminopeptidase 3", "protein_names_refseq": "X-Pro aminopeptidase 3; aminopeptidase P3; probable Xaa-Pro aminopeptidase 3; xaa-Pro aminopeptidase 3 isoform 2; xaa-Pro aminopeptidase 3", "tax_id": 10090, "disease": "nephronophthisis-like nephropathy 1 (Disease Ontology:DOID:0111117)", "pathway": " (mmu:321003)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "20179356;21750661;34428180", "class_list": "", "function": "Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Leu-Pro-Ala. Also shows low activity towards peptides with Ala or Ser at the P1 position. Promotes TNFRSF1B-mediated phosphorylation of MAPK8/JNK1 and MAPK9/JNK2, suggesting a function as an adapter protein for TNFRSF1B; the effect is independent of XPNPEP3 peptidase activity. May inhibit apoptotic cell death induced via TNF-TNFRSF1B signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BHT9", "ec_number_list": [], "go_molecular_function": "GO:0030145 manganese ion binding;GO:0042803 protein homodimerization activity;GO:0004177 aminopeptidase activity;GO:0070006 metalloaminopeptidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0016485 protein processing;GO:0003094 glomerular filtration", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "B7ZMP1-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CRC0-1", "uniprot_id": [ { "id": "VKOR1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CRC0", "type": "external" } ], "mass": 17768.0, "length": 161, "protein_name": "Vitamin K epoxide reductase complex subunit 1", "gene_name": "Vkorc1", "organism": "Mouse", "refseq_name": "vitamin K epoxide reductase complex subunit 1", "refseq_ac": [ { "id": "NP_848715", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848715", "type": "external" } ], "gene_names_uniprotkb": "Vkorc1", "gene_names_refseq": "D7Wsu86e; Vkorc1", "protein_names_uniprotkb": "Vitamin K epoxide reductase complex subunit 1; 1.17.4.4; Vitamin K1 2,3-epoxide reductase subunit 1", "protein_names_refseq": "phylloquinone epoxide reductase; vitamin K 2,3-epoxide reductase complex subunit 1; vitamin K epoxide reductase complex subunit 1; vitamin K epoxide reductase subunit I; vitamin K1 2,3-epoxide reductase subunit 1; vitamin K1 epoxide reductase (warfarin-sensitive)", "tax_id": 10090, "disease": "warfarin resistance (Disease Ontology:DOID:0080665); warfarin sensitivity (Disease Ontology:DOID:0080666); combined deficiency of vitamin K-dependent clotting factors 2 (Disease Ontology:DOID:0112174)", "pathway": " (mmu:27973); (R-MMU-6806664)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "14765194;15879509;19492146;21750661;35810904;35970209;36309944;37453647", "class_list": "", "function": "Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development., [UniProtKB, PubMed, PubMed]; Large-scale identification of rodenticide resistance in Rattus norvegicus and Mus musculus in the Netherlands based on Vkorc1 codon 139 mutations., [RefSeq, PubMed]; Molecular cloning [VKORC1], [RefSeq, PubMed]; The genetic basis for resistance to anticoagulants lies in mutations in Vkorc1., [RefSeq, PubMed]; VKORC1 single nucleotide polymorphisms in rodents in Spain., [RefSeq, PubMed]; Vitamin K is essential for blood clotting but must be enzymatically activated. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. The product of this gene encodes the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is the product of this gene that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance. [provided by RefSeq, Jul 2008]., [RefSeq]; Widespread resistance to anticoagulant rodenticides in Mus musculus domesticus in the city of Barcelona., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.17.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.17.4.4", "type": "external" } ], "go_molecular_function": "GO:0047057 vitamin-K-epoxide reductase (warfarin-sensitive) activity;GO:0047058 vitamin-K-epoxide reductase (warfarin-insensitive) activity;GO:0048038 quinone binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007596 blood coagulation;GO:0006805 xenobiotic metabolic process;GO:0060348 bone development;GO:0030193 regulation of blood coagulation;GO:0017187 peptidyl-glutamic acid carboxylation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9CRC0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48615-1", "uniprot_id": [ { "id": "WNT11_MOUSE", "url": "https://www.uniprot.org/uniprot/P48615", "type": "external" } ], "mass": 39135.0, "length": 354, "protein_name": "Protein Wnt-11", "gene_name": "Wnt11", "organism": "Mouse", "refseq_name": "protein Wnt-11 isoform a precursor", "refseq_ac": [ { "id": "NP_001272721", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001272721", "type": "external" } ], "gene_names_uniprotkb": "Wnt11; Wnt-11", "gene_names_refseq": "Wnt11", "protein_names_uniprotkb": "Protein Wnt-11", "protein_names_refseq": "protein Wnt-11 isoform a precursor; protein Wnt-11; wingless-related MMTV integration site 11", "tax_id": 10090, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); renal cell carcinoma (Disease Ontology:DOID:4450)", "pathway": " (mmu:22411); (R-MMU-3238698); (R-MMU-4086398); (R-MMU-4086400)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "21750661;7547479", "class_list": "", "function": "Ligand for members of the frizzled family of seven transmembrane receptors., [UniProtKB, UniProtKB, UniProtKB]; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005109 frizzled binding;GO:0030295 protein kinase activator activity;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0031012 extracellular matrix", "go_biological_process": "GO:0048341 paraxial mesoderm formation;GO:0048570 notochord morphogenesis;GO:0007165 signal transduction;GO:0007267 cell-cell signaling;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P48615-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D479-1", "uniprot_id": [ { "id": "UVSSA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D479", "type": "external" } ], "mass": 81759.0, "length": 717, "protein_name": "UV-stimulated scaffold protein A", "gene_name": "Uvssa", "organism": "Mouse", "refseq_name": "UV-stimulated scaffold protein A", "refseq_ac": [ { "id": "NP_001074570", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074570", "type": "external" } ], "gene_names_uniprotkb": "Uvssa; Kiaa1530", "gene_names_refseq": "4933407H18Rik; D330017J19Rik; Kiaa1530; Uvssa; mKIAA1530", "protein_names_uniprotkb": "UV-stimulated scaffold protein A", "protein_names_refseq": "UV-stimulated scaffold protein A", "tax_id": 10090, "disease": "UV-sensitive syndrome (Disease Ontology:DOID:0060240)", "pathway": " (mmu:71101); (R-MMU-6781823); (R-MMU-6782135); (R-MMU-6782210)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "21183079;21750661;31219806;34428180", "class_list": "", "function": "Factor involved in transcription-coupled nucleotide excision repair (TC-NER), a mechanism that rapidly removes RNA polymerase II-blocking lesions from the transcribed strand of active genes. Acts as a key adapter that promotes recruitment of factors involved in TC-NER. Facilitates the ubiquitination of the elongating form of RNA polymerase II (RNA pol IIo) at DNA damage sites, thereby promoting RNA pol IIo backtracking and access by the TC-NER machinery to lesion sites. Also promotes stabilization of ERCC6/CSB by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome. Mediates the recruitment of the TFIIH complex and other factors that are required for nucleotide excision repair to RNA polymerase II. Also required to inactivate stalled RNA polymerase II by blocking the access of TCEA1/TFIIS, thereby preventing reactivation of RNA polymerase II. Not involved in processing oxidative damage., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RQ84;B7ZN03;Q3U1A8;Q6P7V8;Q6ZPN7", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000993 RNA polymerase II complex binding;GO:0140463 chromatin-protein adaptor activity;GO:0140870 RNA polymerase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005694 chromosome;GO:0090734 site of DNA damage", "go_biological_process": "GO:0009411 response to UV;GO:0016567 protein ubiquitination;GO:0006283 transcription-coupled nucleotide-excision repair", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9D479-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CR26-1", "uniprot_id": [ { "id": "VTA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CR26", "type": "external" } ], "mass": 33913.0, "length": 309, "protein_name": "Vacuolar protein sorting-associated protein VTA1 homolog", "gene_name": "Vta1", "organism": "Mouse", "refseq_name": "vacuolar protein sorting-associated protein VTA1 homolog isoform 1", "refseq_ac": [ { "id": "NP_079694", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079694", "type": "external" } ], "gene_names_uniprotkb": "Vta1", "gene_names_refseq": "1110001D18Rik; 1110059P08Rik; LIP5; SBP1; Vta1", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein VTA1 homolog; SBP1; SKD1-binding protein 1", "protein_names_refseq": "SKD1-binding protein 1; Vps20-associated 1 homolog; lysosomal trafficking regulator interacting protein-5; vacuolar protein sorting-associated protein VTA1 homolog isoform 1; vacuolar protein sorting-associated protein VTA1 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:66201); (R-MMU-917729)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "15173323;20358264;21750661;25428506;31219806", "class_list": "", "function": "Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies (By similarity). Involved in the sorting and down-regulation of EGFR., [UniProtKB, PubMed]; LIP5 protein expression in a mouse tissue panel and various rodent and human tissues were studied.[LIP5], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0010008 endosome membrane;GO:0005771 multivesicular body", "go_biological_process": "GO:0071985 multivesicular body sorting pathway;GO:0015031 protein transport;GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CR26-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UVV9-1", "uniprot_id": [ { "id": "VWA3A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UVV9", "type": "external" } ], "mass": 130106.0, "length": 1148, "protein_name": "von Willebrand factor A domain-containing protein 3A", "gene_name": "Vwa3a", "organism": "Mouse", "refseq_name": "von Willebrand factor A domain-containing protein 3A", "refseq_ac": [ { "id": "NP_808365", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808365", "type": "external" } ], "gene_names_uniprotkb": "Vwa3a", "gene_names_refseq": "E030013G06Rik; Vwa3a", "protein_names_uniprotkb": "von Willebrand factor A domain-containing protein 3A", "protein_names_refseq": "von Willebrand factor A domain-containing protein 3A", "tax_id": 10090, "disease": "", "pathway": " (mmu:233813)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C349", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3UVV9-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ERK4-1", "uniprot_id": [ { "id": "XPO2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ERK4", "type": "external" } ], "mass": 110455.0, "length": 971, "protein_name": "Exportin-2", "gene_name": "Cse1l", "organism": "Mouse", "refseq_name": "exportin-2", "refseq_ac": [ { "id": "NP_076054", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076054", "type": "external" } ], "gene_names_uniprotkb": "Cse1l; Xpo2", "gene_names_refseq": "2610100P18Rik; Capts; Cas; Cse1l; Xpo2", "protein_names_uniprotkb": "Exportin-2; Chromosome segregation 1-like protein; Exp2; Importin-alpha re-exporter", "protein_names_refseq": "chromosome segregation 1-like protein; exp2; exportin-2; importin-alpha re-exporter", "tax_id": 10090, "disease": "", "pathway": " (mmu:110750)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "11564884;12510150;21750661;22872234;23806821;25428506;26070816;26495903;28528544;30084848;30779550;31219806;33300544;34428180;37507081;39627609", "class_list": "", "function": "CSE1L knockdown reduced Ras-induced metastasis of B16F10 melanoma cells in C57BL/6 mice. v-H-Ras expression altered the cellular trafficking of CSE1L and increased CSE1L secretion., [RefSeq, PubMed]; CSE1L/CAS has a role in proliferation and apoptosis [review] Review article, [RefSeq, PubMed]; Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus., [UniProtKB, UniProtKB]; Serum phospho-CSE1L is useful for early detecting the efficacy of targeted therapy in initial treatment. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding;GO:0005049 nuclear export signal receptor activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006611 protein export from nucleus;GO:0006886 intracellular protein transport;GO:0006913 nucleocytoplasmic transport", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9ERK4-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70410-1", "uniprot_id": [ { "id": "V2R1_MOUSE", "url": "https://www.uniprot.org/uniprot/O70410", "type": "external" } ], "mass": 102349.0, "length": 912, "protein_name": "Vomeronasal type-2 receptor 1", "gene_name": "Vmn2r1", "organism": "Mouse", "refseq_name": "vomeronasal type-2 receptor 1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_064302", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064302", "type": "external" } ], "gene_names_uniprotkb": "Vmn2r1", "gene_names_refseq": "Casrl1; EG56544; Gm34462; V2r83; Vmn2r1", "protein_names_uniprotkb": "Vomeronasal type-2 receptor 1; Putative pheromone receptor V2R1; V2Rx", "protein_names_refseq": "calcium-sensing receptor like 1; pheromone receptor V2Rx; putative pheromone receptor V2R1; putative pheromone receptor V2R2; tissue-type vomeronasal neurons putative pheromone receptor V2; vomeronasal receptor Vmn2r1; vomeronasal type-2 receptor 1 isoform 1 precursor; vomeronasal type-2 receptor 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:56544)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11157070;21112400;21750661;34428180;38447057;9292726", "class_list": "", "function": "Circular RNA CircVmn2r1 Acts as a miR-223-3p Sponge to Promote Kidney Aging by Regulating NLRP3 Expression in Mice., [RefSeq, PubMed]; Great majority of vomeronasal sensory neurons that express intact V2rf2 coexpress Vmn2r1 immunoreactivity, [RefSeq, PubMed]; Putative pheromone receptor., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q0WXF6", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0038022 G protein-coupled olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0030425 dendrite", "go_biological_process": "GO:0030182 neuron differentiation;GO:0019236 response to pheromone", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O70410-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TWF6-1", "uniprot_id": [ { "id": "WDR70_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TWF6", "type": "external" } ], "mass": 73119.0, "length": 657, "protein_name": "WD repeat-containing protein 70", "gene_name": "Wdr70", "organism": "Mouse", "refseq_name": "WD repeat-containing protein 70 isoform 1", "refseq_ac": [ { "id": "NP_001074871", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074871", "type": "external" } ], "gene_names_uniprotkb": "Wdr70", "gene_names_refseq": "4833422F06Rik; Wdr70", "protein_names_uniprotkb": "WD repeat-containing protein 70", "protein_names_refseq": "WD repeat-containing protein 70 isoform 1; WD repeat-containing protein 70", "tax_id": 10090, "disease": "", "pathway": " (mmu:545085); (R-MMU-72163)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "19131326;21183079;21750661;22872234;31219806;34203471;34428180;36210013", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005681 spliceosomal complex;GO:0035861 site of double-strand break;GO:0071006 U2-type catalytic step 1 spliceosome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q3TWF6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CX11-1", "uniprot_id": [ { "id": "UTP23_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CX11", "type": "external" } ], "mass": 28380.0, "length": 249, "protein_name": "rRNA-processing protein UTP23 homolog", "gene_name": "Utp23", "organism": "Mouse", "refseq_name": "rRNA-processing protein UTP23 homolog", "refseq_ac": [ { "id": "NP_084408", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084408", "type": "external" } ], "gene_names_uniprotkb": "Utp23", "gene_names_refseq": "1700010I21Rik; D530033C11Rik; Utp23", "protein_names_uniprotkb": "rRNA-processing protein UTP23 homolog", "protein_names_refseq": "UTP23, small subunit (SSU) processome component, homolog; rRNA-processing protein UTP23 homolog", "tax_id": 10090, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861)", "pathway": " (mmu:78581)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "Involved in rRNA-processing and ribosome biogenesis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BY14", "ec_number_list": [], "go_molecular_function": "GO:0003730 mRNA 3'-UTR binding;GO:0048027 mRNA 5'-UTR binding;GO:0070181 small ribosomal subunit rRNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0032040 small-subunit processome", "go_biological_process": "GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CX11-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYS1-1", "uniprot_id": [ { "id": "WNT16_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QYS1", "type": "external" } ], "mass": 40727.0, "length": 364, "protein_name": "Protein Wnt-16", "gene_name": "Wnt16", "organism": "Mouse", "refseq_name": "protein Wnt-16 precursor", "refseq_ac": [ { "id": "NP_444346", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444346", "type": "external" } ], "gene_names_uniprotkb": "Wnt16", "gene_names_refseq": "E130309I19Rik; Wnt16", "protein_names_uniprotkb": "Protein Wnt-16", "protein_names_refseq": "protein Wnt-16 precursor; protein Wnt-16; wingless-related MMTV integration site 16", "tax_id": 10090, "disease": "", "pathway": " (mmu:93735); (R-MMU-3238698)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10500199;21750661;36974338;38123514", "class_list": "", "function": "Ligand for members of the frizzled family of seven transmembrane receptors., [UniProtKB, UniProtKB, UniProtKB]; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity)., [UniProtKB]; WNT16b promotes the proliferation and self-renewal of human limbal epithelial stem/progenitor cells via activating the calcium/calcineurin A/NFATC2 pathway., [RefSeq, PubMed]; Wnt16 Promotes Vascular Smooth Muscle Contractile Phenotype and Function via Taz (Wwtr1) Activation in Male LDLR-/- Mice., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q14BF7", "ec_number_list": [], "go_molecular_function": "GO:0005109 frizzled binding;GO:0005125 cytokine activity;GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005576 extracellular region", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0046330 positive regulation of JNK cascade;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0030216 keratinocyte differentiation;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9QYS1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41588-1", "uniprot_id": [ { "id": "VIPR2_MOUSE", "url": "https://www.uniprot.org/uniprot/P41588", "type": "external" } ], "mass": 49474.0, "length": 437, "protein_name": "Vasoactive intestinal polypeptide receptor 2", "gene_name": "Vipr2", "organism": "Mouse", "refseq_name": "vasoactive intestinal polypeptide receptor 2 isoform 1 precursor", "refseq_ac": [ { "id": "NP_033537", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033537", "type": "external" } ], "gene_names_uniprotkb": "Vipr2", "gene_names_refseq": "VPAC2R; VPAC2; Vip2; Vipr2", "protein_names_uniprotkb": "Vasoactive intestinal polypeptide receptor 2; PACAP type III receptor; PACAP-R-3; PACAP-R3; Pituitary adenylate cyclase-activating polypeptide type III receptor; VIP-R-2", "protein_names_refseq": "PACAP type III receptor; PACAP-R-3; PACAP-R3; VIP receptor subtype 2; VIP-R-2; VPAC2 receptor; pituitary adenylate cyclase-activating polypeptide type III receptor; vasoactive intestinal polypeptide receptor 2 isoform 1 precursor; vasoactive intestinal polypeptide receptor 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:22355); (R-MMU-418555); (R-MMU-420092)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "16800626;21750661;25428506;31599954;37946684;8146174;8784257", "class_list": "", "function": "G protein-coupled receptor activated by the neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP). Binds VIP and both PACAP27 and PACAP38 bioactive peptides with the order of ligand affinity of VIP = PACAP38 > PACAP27. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway (By similarity). May be coupled to phospholipase C., [UniProtKB, UniProtKB]; Gene deletion of the PACAP/VIP receptor, VPAC2R, alters glycemic responses during metabolic and psychogenic stress in adult female mice., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "P97750", "ec_number_list": [], "go_molecular_function": "GO:0001634 pituitary adenylate cyclase-activating polypeptide receptor activity;GO:0017046 peptide hormone binding;GO:0008528 G protein-coupled peptide receptor activity;GO:0004999 vasoactive intestinal polypeptide receptor activity;GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007190 activation of adenylate cyclase activity;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0048662 negative regulation of smooth muscle cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P41588-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R5M2-1", "uniprot_id": [ { "id": "WNT9A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R5M2", "type": "external" } ], "mass": 40388.0, "length": 365, "protein_name": "Protein Wnt-9a", "gene_name": "Wnt9a", "organism": "Mouse", "refseq_name": "protein Wnt-9a precursor", "refseq_ac": [ { "id": "NP_647459", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647459", "type": "external" } ], "gene_names_uniprotkb": "Wnt9a; Wnt14", "gene_names_refseq": "Wnt14; Wnt9a; wnt-14", "protein_names_uniprotkb": "Protein Wnt-9a; Protein Wnt-14", "protein_names_refseq": "protein Wnt-9a precursor; protein Wnt-9a; wingless-type MMTV integration site 14; wingless-type MMTV integration site 9A", "tax_id": 10090, "disease": "breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); cholangiocarcinoma (Disease Ontology:DOID:4947)", "pathway": " (mmu:216795); (R-MMU-3238698)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;11836627;16818445;21750661", "class_list": "", "function": "Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development (PubMed:16818445). Plays a redundant role in maintaining joint integrity (PubMed:16818445)., [UniProtKB, PubMed, UniProtKB]; Ligand for members of the frizzled family of seven transmembrane receptors., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005109 frizzled binding;GO:0005125 cytokine activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0008285 negative regulation of cell population proliferation;GO:0045597 positive regulation of cell differentiation;GO:0030182 neuron differentiation;GO:0035115 embryonic forelimb morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8R5M2-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91V37-1", "uniprot_id": [ { "id": "VATO_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91V37", "type": "external" } ], "mass": 21607.0, "length": 205, "protein_name": "V-type proton ATPase 21 kDa proteolipid subunit c''", "gene_name": "Atp6v0b", "organism": "Mouse", "refseq_name": "V-type proton ATPase 21 kDa proteolipid subunit c'' isoform 1", "refseq_ac": [ { "id": "NP_291095", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_291095", "type": "external" } ], "gene_names_uniprotkb": "Atp6v0b; Atp6f", "gene_names_refseq": "2310024H13Rik; Atp6f; Atp6v0b; VMA16", "protein_names_uniprotkb": "V-type proton ATPase 21 kDa proteolipid subunit c''; 23 kDa subunit of V-ATPase; V-ATPase 21 kDa proteolipid subunit c''; Vacuolar proton pump 21 kDa proteolipid subunit c''", "protein_names_refseq": "23 kDa subunit of V-ATPase; ATPase, H+ transporting, V0 subunit B; ATPase, H+ transporting, lysosomal (vacuolar proton pump); ATPase, H+ transporting, lysosomal 21kDa, V0 subunit B; V-ATPase 21 kDa proteolipid subunit c''; V-ATPase 21 kDa proteolipid subunit; V-type proton ATPase 21 kDa proteolipid subunit c'' isoform 1; V-type proton ATPase 21 kDa proteolipid subunit c''; V-type proton ATPase 21 kDa proteolipid subunit; vacuolar proton pump 21 kDa proteolipid subunit c''; vacuolar proton pump 21 kDa proteolipid subunit", "tax_id": 10090, "disease": "", "pathway": " (mmu:114143); (R-MMU-1222556); (R-MMU-77387); (R-MMU-917977); (R-MMU-9639288); (R-MMU-983712)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "11441017;11675001;21750661;22467717;38555350", "class_list": "", "function": "Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment., [UniProtKB, UniProtKB, UniProtKB]; Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008553 P-type proton-exporting transporter activity;GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0033176 proton-transporting V-type ATPase complex;GO:0005768 endosome;GO:0016020 membrane;GO:0030665 clathrin-coated vesicle membrane;GO:0016471 vacuolar proton-transporting V-type ATPase complex", "go_biological_process": "GO:1902600 proton transmembrane transport;GO:0038020 insulin receptor recycling", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q91V37-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35468-1", "uniprot_id": [ { "id": "WNT9B_MOUSE", "url": "https://www.uniprot.org/uniprot/O35468", "type": "external" } ], "mass": 38982.0, "length": 359, "protein_name": "Protein Wnt-9b", "gene_name": "Wnt9b", "organism": "Mouse", "refseq_name": "protein Wnt-9b isoform 1 precursor", "refseq_ac": [ { "id": "NP_035849", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035849", "type": "external" } ], "gene_names_uniprotkb": "Wnt9b; Wnt14b; Wnt15", "gene_names_refseq": "Wnt14b; Wnt15; Wnt9b; clf1; clf; wnt-14b; wnt-15", "protein_names_uniprotkb": "Protein Wnt-9b; Protein Wnt-14b; Protein Wnt-15", "protein_names_refseq": "protein Wnt-14b; protein Wnt-9b isoform 1 precursor; protein Wnt-9b; wingless-type MMTV integration site 15; wingless-type MMTV integration site 9B; wingless-type MMTV integration site family, member 15", "tax_id": 10090, "disease": "", "pathway": " (mmu:22412); (R-MMU-3238698)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;11786923;12573259;16054034;17537789;22461561;25257647;9441749", "class_list": "", "function": "Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:16054034, PubMed:17537789, PubMed:22461561). Required for normal embryonic kidney development, and for normal development of the urogenital tract, including uterus and part of the oviduct and the upper vagina in females, and epididymis and vas deferens in males (PubMed:16054034). Activates a signaling cascade in the metanephric mesenchyme that induces tubulogenesis (PubMed:16054034, PubMed:17537789). Acts upstream of WNT4 in the signaling pathways that mediate development of kidney tubules and the Muellerian ducts (PubMed:16054034). Plays a role in cranofacial development and is required for normal fusion of the palate during embryonic development (PubMed:16054034, PubMed:22461561, PubMed:25257647)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8VI90", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005109 frizzled binding;GO:0005125 cytokine activity;GO:0048018 receptor ligand activity;GO:0039706 co-receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:1990851 Wnt-Frizzled-LRP5/6 complex", "go_biological_process": "GO:0009786 regulation of asymmetric cell division;GO:0060993 kidney morphogenesis;GO:0072038 mesenchymal stem cell maintenance involved in nephron morphogenesis;GO:0003339 regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis;GO:0035150 regulation of tube size", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O35468-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70283-1", "uniprot_id": [ { "id": "WNT2B_MOUSE", "url": "https://www.uniprot.org/uniprot/O70283", "type": "external" } ], "mass": 43753.0, "length": 389, "protein_name": "Protein Wnt-2b", "gene_name": "Wnt2b", "organism": "Mouse", "refseq_name": "protein Wnt-2b", "refseq_ac": [ { "id": "NP_033546", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033546", "type": "external" } ], "gene_names_uniprotkb": "Wnt2b; Wnt13", "gene_names_refseq": "Wnt13; Wnt2b", "protein_names_uniprotkb": "Protein Wnt-2b; Protein Wnt-13", "protein_names_refseq": "protein Wnt-2b; wingless related MMTV integration site 2b; wnt-13", "tax_id": 10090, "disease": "congenital diarrhea (Disease Ontology:DOID:0060774); endodermal sinus tumor (Disease Ontology:DOID:1911); teratoma (Disease Ontology:DOID:3307)", "pathway": " (mmu:22414); (R-MMU-3238698)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;19686689;38697357;9545553;9584130", "class_list": "", "function": "Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:19686689). Plays a redundant role in embryonic lung development (PubMed:19686689)., [UniProtKB, PubMed]; WNT2B Deficiency Causes Enhanced Susceptibility to Colitis Due to Increased Inflammatory Cytokine Production., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O88530;Q544L3", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005109 frizzled binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0060638 mesenchymal-epithelial cell signaling;GO:0007165 signal transduction;GO:0007267 cell-cell signaling;GO:0008584 male gonad development;GO:0009887 animal organ morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O70283-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O89116-1", "uniprot_id": [ { "id": "VTI1A_MOUSE", "url": "https://www.uniprot.org/uniprot/O89116", "type": "external" } ], "mass": 24986.0, "length": 217, "protein_name": "Vesicle transport through interaction with t-SNAREs homolog 1A", "gene_name": "Vti1a", "organism": "Mouse", "refseq_name": "vesicle transport through interaction with t-SNAREs homolog 1A isoform 3", "refseq_ac": [ { "id": "NP_001280615", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001280615", "type": "external" } ], "gene_names_uniprotkb": "Vti1a; Vti1l2; Vti1", "gene_names_refseq": "1110014F16Rik; 1110018K19Rik; 4921537J05Rik; MVti1a; MVti1; Vti1-rp2; Vti1a; Vti1", "protein_names_uniprotkb": "Vesicle transport through interaction with t-SNAREs homolog 1A; Vesicle transport v-SNARE protein Vti1-like 2; Vti1-rp2", "protein_names_refseq": "vesicle transport through interaction with t-SNAREs 1 homolog; vesicle transport through interaction with t-SNAREs homolog 1A isoform 3; vesicle transport through interaction with t-SNAREs homolog 1A; vesicle transport v-SNARE protein Vti1-like 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:53611); (R-MMU-6811438); (R-MMU-6811440)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "19138172;21750661;26740625;33774122;36419086;9553086;9705316", "class_list": "", "function": "Ablation of Vti1a/1b Triggers Neural Progenitor Pool Depletion and Cortical Layer 5 Malformation in Late-embryonic Mouse Cortex., [RefSeq, PubMed]; Primary neurons lacking the SNAREs vti1a and vti1b show altered neuronal development. Publication Status: Online-Only, [RefSeq, PubMed]; V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be concerned with increased secretion of cytokines associated with cellular senescence., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q545P9", "ec_number_list": [], "go_molecular_function": "GO:0000149 SNARE binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0043025 neuronal cell body", "go_biological_process": "GO:0050882 voluntary musculoskeletal movement;GO:0006886 intracellular protein transport;GO:0016236 macroautophagy;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O89116-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01173-1", "uniprot_id": [ { "id": "WAP_MOUSE", "url": "https://www.uniprot.org/uniprot/P01173", "type": "external" } ], "mass": 14423.0, "length": 134, "protein_name": "Whey acidic protein", "gene_name": "Wap", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Wap", "gene_names_refseq": "", "protein_names_uniprotkb": "Whey acidic protein; WAP", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:22373)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;6095207;6896234;6975276", "class_list": "", "function": "Could be a protease inhibitor. May play an important role in mammary gland development and tissue remodeling., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P70230;Q61023", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0045735 nutrient reservoir activity;GO:0030414 peptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P01173-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P05531-1", "uniprot_id": [ { "id": "XLR_MOUSE", "url": "https://www.uniprot.org/uniprot/P05531", "type": "external" } ], "mass": 24613.0, "length": 208, "protein_name": "X-linked lymphocyte-regulated protein PM1", "gene_name": "Xlr", "organism": "Mouse", "refseq_name": "X-linked lymphocyte-regulated protein PM1 isoform a", "refseq_ac": [ { "id": "NP_001278676", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278676", "type": "external" } ], "gene_names_uniprotkb": "Xlr", "gene_names_refseq": "Xlr", "protein_names_uniprotkb": "X-linked lymphocyte-regulated protein PM1", "protein_names_refseq": "X-linked gene family of B-cell surface antigens; X-linked lymphocyte-regulated complex; X-linked lymphocyte-regulated protein PM1 isoform a; X-linked lymphocyte-regulated protein pM1", "tax_id": 10090, "disease": "spermatogenic failure 4 (Disease Ontology:DOID:0070176)", "pathway": " (mmu:22441)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12390899;20395201;30084848;3681192", "class_list": "", "function": "X-linked lymphocyte-regulated protein pM1 (XMR), XLR, and SCP3 render tumor cells resistant to antitumor immunity, [RefSeq, PubMed]; Xlr (X linked, lymphocyte regulated) was expressed in oocytes throughout meiotic prophase I. These findings indicate a sex-specific expression of two closely related members of the Xlr gene family during meiotic prophase I., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0000795 synaptonemal complex", "go_biological_process": "GO:0007286 spermatid development;GO:0051321 meiotic cell cycle;GO:0035092 sperm DNA condensation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P05531-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13373-1", "uniprot_id": [ { "id": "VPB1B_MOUSE", "url": "https://www.uniprot.org/uniprot/P13373", "type": "external" } ], "mass": 16052.0, "length": 142, "protein_name": "Immunoglobulin omega chain", "gene_name": "Vpreb1b", "organism": "Mouse", "refseq_name": "immunoglobulin omega chain precursor", "refseq_ac": [ { "id": "NP_058679", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058679", "type": "external" } ], "gene_names_uniprotkb": "Vpreb1b; Vpreb2", "gene_names_refseq": "CD179b; VpreB1; Vpreb-2; Vpreb1b; Vpreb2", "protein_names_uniprotkb": "Immunoglobulin omega chain; Protein VPreB2; V-set pre-B cell surrogate light chain 1B", "protein_names_refseq": "Lambda 5; immunoglobulin omega chain precursor; immunoglobulin omega chain; pre-B lymphocyte gene 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:22363)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22566564;25523463;3117530", "class_list": "", "function": "Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells. This complex presumably regulates Ig gene rearrangements in the early steps of B-cell differentiation., [UniProtKB]; Data show no autoantibody production was detectable in surrogate light chain (SLC) components VpreB/CD179a and lambda5/CD179b transgenic mice., [RefSeq, PubMed]; VpreB probes the fitness of newly generated VH domains of IgH chains for later pairing with IgL chains, and its non-Ig part fixes the preBCRs on the surface., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0006955 immune response;GO:0000902 cell morphogenesis;GO:0001782 B cell homeostasis;GO:0048872 homeostasis of number of cells;GO:0042100 B cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P13373-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27641-1", "uniprot_id": [ { "id": "XRCC5_MOUSE", "url": "https://www.uniprot.org/uniprot/P27641", "type": "external" } ], "mass": 83057.0, "length": 732, "protein_name": "DNA repair protein Ku80", "gene_name": "Xrcc5", "organism": "Mouse", "refseq_name": "DNA repair protein Ku80 isoform 1", "refseq_ac": [ { "id": "NP_033559", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033559", "type": "external" } ], "gene_names_uniprotkb": "Xrcc5; G22p2", "gene_names_refseq": "CTC85; CTCBF; Ku80; Ku86; Kup80; Xrcc5", "protein_names_uniprotkb": "DNA repair protein Ku80; 4.2.99.18; 5.6.2.4; ATP-dependent DNA helicase 2 subunit 2; ATP-dependent DNA helicase II 80 kDa subunit; CTC box-binding factor 85 kDa subunit; CTC85; CTCBF; DNA repair protein XRCC5; Ku autoantigen protein p86 homolog; Ku80; Nuclear factor IV; X-ray repair cross-complementing protein 5", "protein_names_refseq": "ATP-dependent DNA helicase 2 subunit 2; ATP-dependent DNA helicase II 80 kDa subunit; CTC box-binding factor 85 kDa subunit; DNA repair protein Ku80 isoform 1; DNA repair protein Ku80; DNA repair protein XRCC5; X-ray repair complementing defective repair in Chinese hamster cells 5; X-ray repair cross-complementing protein 5; ku autoantigen protein p86 homolog; nuclear factor IV", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); squamous cell carcinoma (Disease Ontology:DOID:1749); rectum cancer (Disease Ontology:DOID:1993); basal cell carcinoma (Disease Ontology:DOID:2513); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (mmu:22596); (R-MMU-5693571); (R-MMU-6798695)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "1641347;19892989;25605945;30017584;31219806;32355287;34428180;35820727;35910805;37407587;37900135;8605992", "class_list": "", "function": "DCLK1 promotes colorectal cancer stemness and aggressiveness via the XRCC5/COX2 axis. Publication Status: Online-Only, [RefSeq, PubMed]; DNA-binding protein critical for the DNA damage response, specifically in repairing double-strand breaks (DSBs) via the classical non-homologous end joining (NHEJ) pathway. It forms a heterodimer with XRCC6 (Ku70), creating the Ku70:Ku80 heterodimer (Ku complex), which serves as a DNA end-binding complex. It primarily binds DSBs and recruits essential repair factors, assembling the core long-range NHEJ complex to facilitate the alignment and ligation of broken DNA ends. This pathway ensures the rapid repair of cytotoxic and mutagenic DSBs and contributes to the generation of diversity in T-cell receptors and antibodies through mechanisms such as V(D)J recombination. Likely acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), catalyzing the beta-elimination of the 5'-deoxyribose-5-phosphate at abasic sites near DSBs. This activity cleans the termini of abasic sites, a common form of nucleotide damage, preparing broken ends for ligation. It may also possess 3'-5' DNA helicase activity, although this has not been confirmed in vivo, and its physiological significance remains unclear. Beyond DNA repair, the protein contributes to telomere maintenance. It is also implicated in transcriptional regulation, acting as a cofactor for various transcription factors. It plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Can also bind RNAs and recruits PRKDC to a wide range of cellular RNAs, including the U3 small nucleolar RNA, playing a role in the biogenesis of ribosomal RNAs., [UniProtKB, UniProtKB]; Xrcc5/KU80 is not required for the survival or activation of prophase-arrested oocytes in primordial follicles. Publication Status: Online-Only, [RefSeq, PubMed]; Xrcc5/Ku80 is required for the repair of DNA damage in fully grown meiotically arrested mammalian oocytes. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TE46;Q3TJT0;Q3TN82;Q80UT1;Q8C4N6;Q8K1K7;Q9R169", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": 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"type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "1.11.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.7", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "5.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "2.1.1.357", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.357", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" } ], "go_molecular_function": "GO:0043138 3'-5' DNA helicase activity;GO:0051575 5'-deoxyribose-5-phosphate lyase activity;GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0003684 damaged DNA binding", "go_cellular_component": "GO:0070419 nonhomologous end joining complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:1904430 negative regulation of t-circle formation;GO:0006351 DNA-templated transcription;GO:0008283 cell population proliferation;GO:0045087 innate immune response;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P27641-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28047-1", "uniprot_id": [ { "id": "WNT7B_MOUSE", "url": "https://www.uniprot.org/uniprot/P28047", "type": "external" } ], "mass": 39302.0, "length": 349, "protein_name": "Protein Wnt-7b", "gene_name": "Wnt7b", "organism": "Mouse", "refseq_name": "protein Wnt-7b isoform 3", "refseq_ac": [ { "id": "NP_001157105", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157105", "type": "external" } ], "gene_names_uniprotkb": "Wnt7b; Wnt-7b", "gene_names_refseq": "Wnt-7b; Wnt7b", "protein_names_uniprotkb": "Protein Wnt-7b", "protein_names_refseq": "protein Wnt-7b isoform 3; protein Wnt-7b; wingless-related MMTV integration site 7B", "tax_id": 10090, "disease": "urinary bladder cancer (Disease Ontology:DOID:11054); breast cancer (Disease Ontology:DOID:1612); breast fibroadenoma (Disease Ontology:DOID:1618)", "pathway": " (mmu:22422); (R-MMU-3238698)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;10866835;11543617;15923619;21750661;2279700;28803732;35820727", "class_list": "", "function": "Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:15923619, PubMed:28803732). Required for normal fusion of the chorion and the allantois during placenta development (PubMed:11543617). Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (PubMed:28803732)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 3, "disease_count": 3, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q80US5", "ec_number_list": [], "go_molecular_function": "GO:0005109 frizzled binding;GO:0005125 cytokine activity;GO:0048018 receptor ligand activity;GO:1902379 chemoattractant activity involved in axon guidance;GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005788 endoplasmic reticulum lumen;GO:0009986 cell surface;GO:0005576 extracellular region", "go_biological_process": "GO:0060535 trachea cartilage morphogenesis;GO:0016332 establishment or maintenance of polarity of embryonic epithelium;GO:0032536 regulation of cell projection size;GO:0060482 lobar bronchus development;GO:0072060 outer medullary collecting duct development", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P28047-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46467-1", "uniprot_id": [ { "id": "VPS4B_MOUSE", "url": "https://www.uniprot.org/uniprot/P46467", "type": "external" } ], "mass": 49419.0, "length": 444, "protein_name": "Vacuolar protein sorting-associated protein 4B", "gene_name": "Vps4b", "organism": "Mouse", "refseq_name": "vacuolar protein sorting-associated protein 4B", "refseq_ac": [ { "id": "NP_033216", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033216", "type": "external" } ], "gene_names_uniprotkb": "Vps4b; Skd1", "gene_names_refseq": "8030489C12Rik; Skd1; Vps4b", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 4B; 3.6.4.6; Protein SKD1; Suppressor of K(+) transport growth defect 1", "protein_names_refseq": "suppressor of K(+) transport growth defect 1; suppressor of K+ transport defect 1; vacuolar protein sorting-associated protein 4B", "tax_id": 10090, "disease": "attention deficit hyperactivity disorder (Disease Ontology:DOID:1094)", "pathway": " (mmu:20479); (R-MMU-917729)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "10393249;10637304;10679028;12594041;15173323;18796009;19144319;21183079;25605945;26740625;31218890;31219806;33682352;34041875;35379808;37507081;8082782", "class_list": "", "function": "(Microbial infection) In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (lentiviruses)., [UniProtKB, UniProtKB]; Expressions of cytokeratin 14 and proliferating cell nuclear antigen in the Hertwig's epithelial root sheath of a Vps4b knockout mouse., [RefSeq, PubMed]; Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Loss of Rnf31 and Vps4b sensitizes pancreatic cancer to T cell-mediated killing. Publication Status: Online-Only, [RefSeq, PubMed]; VPS4B deficiency causes early embryonic lethality and induces signal transduction disorders of cell endocytosis., [RefSeq, PubMed]; VPS4B, via Wnt-beta-catenin signalling, acts as a regulator of the proliferation and differentiation of hDPSCs, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, 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"https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0016887 ATP hydrolysis activity;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005813 centrosome", "go_biological_process": "GO:0001778 plasma membrane repair;GO:0007034 vacuolar transport;GO:0010824 regulation of centrosome duplication;GO:0031468 nuclear membrane reassembly;GO:0036258 multivesicular body assembly", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P46467-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63082-1", "uniprot_id": [ { "id": "VATL_MOUSE", "url": "https://www.uniprot.org/uniprot/P63082", "type": "external" } ], "mass": 15808.0, "length": 155, "protein_name": "V-type proton ATPase 16 kDa proteolipid subunit c", "gene_name": "Atp6v0c", "organism": "Mouse", "refseq_name": "V-type proton ATPase 16 kDa proteolipid subunit c isoform b", "refseq_ac": [ { "id": "NP_033859", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033859", "type": "external" } ], "gene_names_uniprotkb": "Atp6v0c; Atp6c; Atp6l; Atpl; Mvp", "gene_names_refseq": "Atp6c2; Atp6c; Atp6l; Atp6v0c; Atpl-rs1; Atpl; PL16; VATL; Vma3", "protein_names_uniprotkb": "V-type proton ATPase 16 kDa proteolipid subunit c; PL16; V-ATPase 16 kDa proteolipid subunit c; Vacuolar proton pump 16 kDa proteolipid subunit c", "protein_names_refseq": "ATPase, H+ transporting, lysosomal (vacuolar proton pump) 16 kDa; ATPase, H+ transporting, lysosomal 16kD, V0 subunit C; ATPase, H+ transporting, lysosomal 2; H(+)-ATPase (mvp); V-ATPase 16 kDa proteolipid subunit c; V-ATPase 16 kDa proteolipid subunit; V-type proton ATPase 16 kDa proteolipid subunit c isoform b; V-type proton ATPase 16 kDa proteolipid subunit c; V-type proton ATPase 16 kDa proteolipid subunit; vacuolar proton pump 16 kDa proteolipid subunit c; vacuolar proton pump 16 kDa proteolipid subunit", "tax_id": 10090, "disease": "early-onset epilepsy 3 (Disease Ontology:DOID:0070472); intellectual disability (Disease Ontology:DOID:1059); epilepsy (Disease Ontology:DOID:1826); thyroid gland carcinoma (Disease Ontology:DOID:3963)", "pathway": " (mmu:11984); (R-MMU-1222556); (R-MMU-6798695); (R-MMU-77387); (R-MMU-917977); (R-MMU-9639288); (R-MMU-983712)", "pathway_count": 7, "publication_count": 19, "publication_id_list": "11441017;11495928;11595166;1828149;18299400;19224205;19892989;20173027;21750661;22872234;25605945;26740625;31219806;33300544;34428180;34588579;35820727;38481802;8741845", "class_list": "", "function": "Impaired TFEB-mediated autophagy-lysosome fusion promotes tubular cell cycle G2/M arrest and renal fibrosis by suppressing ATP6V0C expression and interacting with SNAREs. Publication Status: Online-Only, [RefSeq, PubMed]; Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment., [UniProtKB, UniProtKB]; Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Vacuolar-type proton ATPase is required for maintenance of apicobasal polarity of embryonic visceral endoderm. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P23967;Q3TD69", "ec_number_list": [], "go_molecular_function": "GO:0008553 P-type proton-exporting transporter activity;GO:0031625 ubiquitin protein ligase binding;GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0033176 proton-transporting V-type ATPase complex;GO:0016020 membrane;GO:0030665 clathrin-coated vesicle membrane;GO:0030672 synaptic vesicle membrane;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0007042 lysosomal lumen acidification;GO:0030177 positive regulation of Wnt signaling pathway;GO:0097401 synaptic vesicle lumen acidification;GO:1904093 negative regulation of autophagic cell death", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P63082-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97390-1", "uniprot_id": [ { "id": "VPS45_MOUSE", "url": "https://www.uniprot.org/uniprot/P97390", "type": "external" } ], "mass": 65053.0, "length": 570, "protein_name": "Vacuolar protein sorting-associated protein 45", "gene_name": "Vps45", "organism": "Mouse", "refseq_name": "vacuolar protein sorting-associated protein 45", "refseq_ac": [ { "id": "NP_038869", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038869", "type": "external" } ], "gene_names_uniprotkb": "Vps45; Vps45a", "gene_names_refseq": "Vps45; mVps45", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 45; mVps45", "protein_names_refseq": "vacuolar protein sorting protein 45; vacuolar protein sorting-associated protein 45", "tax_id": 10090, "disease": "severe congenital neutropenia 5 (Disease Ontology:DOID:0112132)", "pathway": " (mmu:22365); (R-MMU-6811438); (R-MMU-983231)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "23741049;25605945;30084848;30779550;31219806;33512427;34203471;34428180;36210013;9045632", "class_list": "", "function": "A crucial role for mVps45 in the delivery of GLUT4 into its specialized, insulin-regulated compartment., [RefSeq, PubMed]; Mammalian VPS45 orchestrates trafficking through the endosomal system., [RefSeq, PubMed]; May play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91VK9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0010008 endosome membrane;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P97390-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97751-1", "uniprot_id": [ { "id": "VIPR1_MOUSE", "url": "https://www.uniprot.org/uniprot/P97751", "type": "external" } ], "mass": 52096.0, "length": 459, "protein_name": "Vasoactive intestinal polypeptide receptor 1", "gene_name": "Vipr1", "organism": "Mouse", "refseq_name": "vasoactive intestinal polypeptide receptor 1 precursor", "refseq_ac": [ { "id": "NP_035833", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035833", "type": "external" } ], "gene_names_uniprotkb": "Vipr1", "gene_names_refseq": "VIP-R1; VPAC1; Vipr1", "protein_names_uniprotkb": "Vasoactive intestinal polypeptide receptor 1; PACAP type II receptor; PACAP-R-2; PACAP-R2; Pituitary adenylate cyclase-activating polypeptide type II receptor; VIP-R-1; VPAC1 receptor", "protein_names_refseq": "PACAP type II receptor; PACAP-R-2; PACAP-R2; VIP receptor subtype 1; VIP-R-1; VPAC1 receptor; pituitary adenylate cyclase-activating polypeptide type II receptor; vasoactive intestinal polypeptide receptor 1 precursor; vasoactive intestinal polypeptide receptor 1", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); achalasia (Disease Ontology:DOID:9164)", "pathway": " (mmu:22354); (R-MMU-418555); (R-MMU-420092)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10331949;11859927;12409228;17242355;36328148;8784267", "class_list": "", "function": "G protein-coupled receptor activated by the neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP). Binds VIP and both PACAP27 and PACAP38 bioactive peptides with the following order of ligand affinity VIP = PACAP27 > PACAP38. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway., [UniProtKB, UniProtKB]; VIP modulation of neural crest differentiation is mediated via VPAC1 and high expression of VPAC1 induces differentiation in and decreases tumorigenicity of neuroblastoma cells., [RefSeq, PubMed]; VPAC1 and VPAC2 receptor deficiencies negatively influence pregnancy outcome through distinct and overlapping modulations of immune, trophoblast and vascular functions., [RefSeq, PubMed]; VPAC1 suggested as mediator of the neuroprotective effects of VIP, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q9JI40;Q9R1T8", "ec_number_list": [], "go_molecular_function": "GO:0001634 pituitary adenylate cyclase-activating polypeptide receptor activity;GO:0017046 peptide hormone binding;GO:0008528 G protein-coupled peptide receptor activity;GO:0004999 vasoactive intestinal polypeptide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P97751-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U515-1", "uniprot_id": [ { "id": "VWCE_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U515", "type": "external" } ], "mass": 97668.0, "length": 929, "protein_name": "von Willebrand factor C and EGF domain-containing protein", "gene_name": "Vwce", "organism": "Mouse", "refseq_name": "von Willebrand factor C and EGF domain-containing protein precursor", "refseq_ac": [ { "id": "NP_082189", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082189", "type": "external" } ], "gene_names_uniprotkb": "Vwce", "gene_names_refseq": "1300015B04Rik; Vwce", "protein_names_uniprotkb": "von Willebrand factor C and EGF domain-containing protein", "protein_names_refseq": "von Willebrand factor C and EGF domain-containing protein precursor; von Willebrand factor C and EGF domain-containing protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:71768)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May be a regulatory element in the beta-catenin signaling pathway and a target for chemoprevention of hapatocellular carcinoma., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "E9QME6", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0098586 cellular response to virus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3U515-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UR50-1", "uniprot_id": [ { "id": "VW5B2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UR50", "type": "external" } ], "mass": 133414.0, "length": 1248, "protein_name": "von Willebrand factor A domain-containing protein 5B2", "gene_name": "Vwa5b2", "organism": "Mouse", "refseq_name": "von Willebrand factor A domain-containing protein 5B2 isoform 1", "refseq_ac": [ { "id": "NP_001138425", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138425", "type": "external" } ], "gene_names_uniprotkb": "Vwa5b2", "gene_names_refseq": "EG328644; Gm1738; Gm931; Vwa5b2", "protein_names_uniprotkb": "von Willebrand factor A domain-containing protein 5B2", "protein_names_refseq": "von Willebrand factor A domain-containing protein 5B2 isoform 1; von Willebrand factor A domain-containing protein 5B2", "tax_id": 10090, "disease": "", "pathway": " (mmu:328643)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25428506;37828378", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q2TB01;Q80WS8;Q8BR57", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3UR50-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q402B2-1", "uniprot_id": [ { "id": "WDR93_MOUSE", "url": "https://www.uniprot.org/uniprot/Q402B2", "type": "external" } ], "mass": 78911.0, "length": 695, "protein_name": "WD repeat-containing protein 93", "gene_name": "Wdr93", "organism": "Mouse", "refseq_name": "WD repeat-containing protein 93 isoform 1", "refseq_ac": [ { "id": "NP_001033016", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033016", "type": "external" } ], "gene_names_uniprotkb": "Wdr93", "gene_names_refseq": "EG626359; Wdr93", "protein_names_uniprotkb": "WD repeat-containing protein 93; Protein MA0035", "protein_names_refseq": "WD repeat-containing protein 93 isoform 1; WD repeat-containing protein 93", "tax_id": 10090, "disease": "", "pathway": " (mmu:626359)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9EKH5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0022900 electron transport chain", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q402B2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5GH62-1", "uniprot_id": [ { "id": "XKR9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5GH62", "type": "external" } ], "mass": 43271.0, "length": 373, "protein_name": "XK-related protein 9", "gene_name": "Xkr9", "organism": "Mouse", "refseq_name": "XK-related protein 9", "refseq_ac": [ { "id": "NP_001011873", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011873", "type": "external" } ], "gene_names_uniprotkb": "Xkr9; Gm1620; Xrg9", "gene_names_refseq": "Gm1620; XRG9; Xkr9", "protein_names_uniprotkb": "XK-related protein 9", "protein_names_refseq": "X Kell blood group precursor related family member 9 homolog; XK-related protein 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:381246)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "25231987", "class_list": "", "function": "Phospholipid scramblase that promotes phosphatidylserine exposure on apoptotic cell surface (PubMed:25231987). Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment (PubMed:25231987)., [UniProtKB, PubMed]; Unlike Xkr8, which is ubiquitously expressed, Xkr4 and Xkr9 expression is tissue-specific., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RWB3", "ec_number_list": [ { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5GH62-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5GH68-1", "uniprot_id": [ { "id": "XKR2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5GH68", "type": "external" } ], "mass": 51778.0, "length": 449, "protein_name": "XK-related protein 2", "gene_name": "Xkrx", "organism": "Mouse", "refseq_name": "XK-related protein 2 isoform 1", "refseq_ac": [ { "id": "NP_899142", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_899142", "type": "external" } ], "gene_names_uniprotkb": "Xkrx; Xkr2; Xrg2", "gene_names_refseq": "A630026F04; Xkrx", "protein_names_uniprotkb": "XK-related protein 2; X Kell blood group-related, X-linked", "protein_names_refseq": "Kell blood group complex subunit-related, X-linked; X Kell blood group precursor related X linked; XK-related protein 2 isoform 1; XK-related protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:331524)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AEK6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5GH68-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SPW0-1", "uniprot_id": [ { "id": "VPS54_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5SPW0", "type": "external" } ], "mass": 110397.0, "length": 977, "protein_name": "Vacuolar protein sorting-associated protein 54", "gene_name": "Vps54", "organism": "Mouse", "refseq_name": "vacuolar protein sorting-associated protein 54 isoform 2", "refseq_ac": [ { "id": "NP_001277557", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277557", "type": "external" } ], "gene_names_uniprotkb": "Vps54", "gene_names_refseq": "Hcc8; Vps54l; Vps54; mSLP8; wr", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 54; Tumor antigen SLP-8p homolog", "protein_names_refseq": "tumor antigen SLP-8p homolog; vacuolar protein sorting 54; vacuolar protein sorting-associated protein 54 isoform 2; vacuolar protein sorting-associated protein 54", "tax_id": 10090, "disease": "amyotrophic lateral sclerosis type 1 (Disease Ontology:DOID:0060193); Werdnig-Hoffmann disease (Disease Ontology:DOID:13137); motor neuron disease (Disease Ontology:DOID:231)", "pathway": " (mmu:245944); (R-MMU-6811440)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;16244655;20615984;21750661", "class_list": "", "function": "Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Within the GARP complex, required to tether the complex to the TGN. Not involved in endocytic recycling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BPB3;Q8CFZ7;Q8CHL5;Q8R3R4;Q8R3X1", "ec_number_list": [], "go_molecular_function": "GO:0019905 syntaxin binding", "go_cellular_component": "GO:0000938 GARP complex;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0048708 astrocyte differentiation;GO:0010992 ubiquitin recycling;GO:0071393 cellular response to progesterone stimulus;GO:0030149 sphingolipid catabolic process;GO:0001701 in utero embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q5SPW0-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99KU0-1", "uniprot_id": [ { "id": "VMP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99KU0", "type": "external" } ], "mass": 45960.0, "length": 406, "protein_name": "Vacuole membrane protein 1", "gene_name": "Vmp1", "organism": "Mouse", "refseq_name": "vacuole membrane protein 1 isoform a", "refseq_ac": [ { "id": "NP_083754", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083754", "type": "external" } ], "gene_names_uniprotkb": "Vmp1", "gene_names_refseq": "3110098I04Rik; 4930579A11Rik; Tango5; Tmem49; Vmp1; mir-21a; ni-2", "protein_names_uniprotkb": "Vacuole membrane protein 1; NF-E2-inducible protein 2; Protein ni-2", "protein_names_refseq": "NF-E2 induceble protein-2; protein ni-2; transmembrane protein 49; vacuole membrane protein 1 isoform a", "tax_id": 10090, "disease": "", "pathway": " (mmu:75909)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "17940279;21173155;21750661;26495903;28890335;31526472;34428180;35617134;36971758;37748280", "class_list": "", "function": "Phospholipid scramblase involved in lipid homeostasis and membrane dynamics processes (By similarity). Has phospholipid scramblase activity toward cholesterol and phosphatidylserine, as well as phosphatidylethanolamine and phosphatidylcholine (By similarity). Required for autophagosome formation: participates in early stages of autophagosome biogenesis at the endoplasmic reticulum (ER) membrane by reequilibrating the leaflets of the ER as lipids are extracted by ATG2 (ATG2A or ATG2B) to mediate autophagosome assembly (PubMed:17940279, PubMed:28890335). Regulates ATP2A2 activity to control ER-isolation membrane contacts for autophagosome formation (By similarity). In addition to autophagy, involved in other processes in which phospholipid scramblase activity is required (By similarity). Modulates ER contacts with lipid droplets, mitochondria and endosomes (By similarity). Plays an essential role in formation of cell junctions (PubMed:31526472). Upon stress such as bacterial and viral infection, promotes formation of cytoplasmic vacuoles followed by cell death (By similarity). Involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; VMP1 prevents Ca2+ overload in endoplasmic reticulum and maintains naive T cell survival., [RefSeq, PubMed]; VMP1 regulates hepatic lipoprotein secretion and NASH independent of autophagy., [RefSeq, PubMed]; WHSC1L1-mediated epigenetic downregulation of VMP1 participates in herpes simplex virus 1 infection-induced mitophagy impairment and neuroinflammation., [RefSeq, PubMed]; Zymophagy, a novel selective autophagy pathway mediated by VMP1-USP9x-p62, prevents pancreatic cell death., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2V655;Q3TX07;Q8BHD3", "ec_number_list": [ { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0017128 phospholipid scramblase activity", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005730 nucleolus;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0034329 cell junction assembly;GO:0042953 lipoprotein transport;GO:0098609 cell-cell adhesion;GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q99KU0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62465-1", "uniprot_id": [ { "id": "VAT1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62465", "type": "external" } ], "mass": 43097.0, "length": 406, "protein_name": "NADPH-dependent quinone oxidoreductase VAT1", "gene_name": "Vat1", "organism": "Mouse", "refseq_name": "NADPH-dependent quinone oxidoreductase VAT1", "refseq_ac": [ { "id": "NP_036167", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036167", "type": "external" } ], "gene_names_uniprotkb": "Vat1", "gene_names_refseq": "VAT-1; Vat1", "protein_names_uniprotkb": "NADPH-dependent quinone oxidoreductase VAT1; 1.6.5.5; Synaptic vesicle membrane protein VAT-1 homolog; VAT-1; Vesicle amine transport 1", "protein_names_refseq": "NADPH-dependent quinone oxidoreductase VAT1; membrane protein of cholinergic synaptic vesicles; synaptic vesicle membrane protein VAT-1 homolog; vesicle amine transport protein 1 homolog (T californica)", "tax_id": 10090, "disease": "", "pathway": " (mmu:26949); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "20484733;25428506;26740625;29637443;30084848;30779550;31219806;31599954;32152506;34203471;34428180;35820727;37453647;9581869", "class_list": "", "function": "MiR-34a and its target genes of FOXP2 and VAT1 are involved in dorsal root ganglia neuron damage under hyperglycemia., [RefSeq, PubMed]; Multifunctional protein with enzymatic and transport activities. Probable NADPH-dependent quinone oxidoreductase which physiological substrates and function are unclear. Alternatively, has also been suggested to mediate the transfer of negatively charged phospholipids including phosphatidic acid (PA), phosphatidylserine (PS) and phosphatidylglycerol (PG) between endoplasmic reticulum and mitochondrial membranes. Could regulate mitochondrial fusion through its interaction with mitofusins., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8R3G0;Q8R3T8", "ec_number_list": [ { "id": "4.6.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.19", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.24", "type": "external" }, { "id": "4.6.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.18", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "1.11.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.4.16.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.5", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "3.2.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.22", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.5.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15", "type": "external" }, { "id": "3.4.21.37", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.37", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.4.21.76", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.76", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "1.8.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003960 quinone reductase (NADPH) activity;GO:0008753 NADPH dehydrogenase (quinone) activity;GO:0120014 phospholipid transfer activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol", "go_biological_process": "GO:0010637 negative regulation of mitochondrial fusion;GO:0120010 intermembrane phospholipid transfer", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q62465-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q65Z40-1", "uniprot_id": [ { "id": "WAPL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q65Z40", "type": "external" } ], "mass": 134070.0, "length": 1200, "protein_name": "Wings apart-like protein homolog", "gene_name": "Wapl", "organism": "Mouse", "refseq_name": "wings apart-like protein homolog isoform 1", "refseq_ac": [ { "id": "NP_001004436", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004436", "type": "external" } ], "gene_names_uniprotkb": "Wapl; Kiaa0261; Wapal", "gene_names_refseq": "A530089A20Rik; DIF-2; FOE; Wapal; Wapl", "protein_names_uniprotkb": "Wings apart-like protein homolog; DIF-2; Dioxin-inducible factor 2; WAPL cohesin release factor", "protein_names_refseq": "dioxin-inducible factor 2; friend of EBNA2; wings apart-like homolog; wings apart-like protein homolog isoform 1; wings apart-like protein homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:218914); (R-MMU-2467813); (R-MMU-2468052); (R-MMU-2470946); (R-MMU-2500257)", "pathway_count": 5, "publication_count": 20, "publication_id_list": "15150110;15345747;15620708;17113138;17242355;19144319;19892989;21183079;21750661;23975099;25428506;25605945;30059200;30084848;30779550;31219806;34428180;35820727;36449618;36471071", "class_list": "", "function": "Decreasing Wapl dosage partially corrects embryonic growth and brain transcriptome phenotypes in Nipbl[+/-] embryos., [RefSeq, PubMed]; Enhancer-promoter interactions and transcription are largely maintained upon acute loss of CTCF, cohesin, WAPL or YY1., [RefSeq, PubMed]; High levels of WAPAL are observed in human cervical cancers, and expression of human WAPAL in mice causes tumor formation., [RefSeq, PubMed]; In mitosis, Wapl-mediated release of cohesin from DNA is essential for proper chromosome segregation and protects cohesin from cleavage by the protease separase, thus enabling mitotic exit in the presence of functional cohesin complexes, [RefSeq, PubMed]; MWAPL may be involved in spermatogenesis and be target genes mediating the reproductive toxicity induced by 2,3,7,8-trachlorodibenzo-p-dioxin ., [RefSeq, PubMed]; Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Studies suggest that the protein encoded by this gene is important for the release of cohesin from chromatin. This gene product is thought to be essential for development, and reduced expression of this gene in cells causes defects in chromatin structure. High levels of expression of the human ortholog of this gene are observed in cervical cancers, and expression of the human ortholog of this gene in mice results in tumor formation. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Aug 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B9EIG8;Q6ZQE9", "ec_number_list": [], "go_molecular_function": "GO:0140083 ATP-dependent protein-DNA unloader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045171 intercellular bridge", "go_biological_process": "GO:0045875 negative regulation of sister chromatid cohesion;GO:0051307 meiotic chromosome separation;GO:0000278 mitotic cell cycle;GO:0008608 attachment of spindle microtubules to kinetochore;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q65Z40-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P1B1-1", "uniprot_id": [ { "id": "XPP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P1B1", "type": "external" } ], "mass": 69591.0, "length": 623, "protein_name": "Xaa-Pro aminopeptidase 1", "gene_name": "Xpnpep1", "organism": "Mouse", "refseq_name": "xaa-Pro aminopeptidase 1 isoform 1", "refseq_ac": [ { "id": "NP_573479", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_573479", "type": "external" } ], "gene_names_uniprotkb": "Xpnpep1", "gene_names_refseq": "D230045I08Rik; Xpnpep1; sAMP", "protein_names_uniprotkb": "Xaa-Pro aminopeptidase 1; 3.4.11.9; Aminoacylproline aminopeptidase; Cytosolic aminopeptidase P; Soluble aminopeptidase P; X-Pro aminopeptidase 1; X-prolyl aminopeptidase 1, soluble; sAmp", "protein_names_refseq": "X-Pro aminopeptidase 1; aminoacylproline aminopeptidase; cytosolic aminopeptidase P; xaa-Pro aminopeptidase 1 isoform 1; xaa-Pro aminopeptidase 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:170750)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "21750661;23131567;25428506;30084848;30779550;31219806;33441619;34428180;36210013;37507081;37828378", "class_list": "", "function": "Altered hippocampal gene expression, glial cell population, and neuronal excitability in aminopeptidase P1 deficiency. Publication Status: Online-Only, [RefSeq, PubMed]; Metalloaminopeptidase that catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro. Contributes to the degradation of bradykinin., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These results suggest an essential role for APP1-mediated peptide metabolism in body and brain development, and indicate a strong causal link between APP1 deficiency and peptiduria., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91Y37", "ec_number_list": [], "go_molecular_function": "GO:0030145 manganese ion binding;GO:0042803 protein homodimerization activity;GO:0004177 aminopeptidase activity;GO:0070006 metalloaminopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0043069 negative regulation of programmed cell death;GO:0010815 bradykinin catabolic process;GO:0140633 CARD8 inflammasome complex assembly", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q6P1B1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P3A4-1", "uniprot_id": [ { "id": "VSIG8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P3A4", "type": "external" } ], "mass": 44187.0, "length": 417, "protein_name": "V-set and immunoglobulin domain-containing protein 8", "gene_name": "Vsig8", "organism": "Mouse", "refseq_name": "V-set and immunoglobulin domain-containing protein 8 precursor", "refseq_ac": [ { "id": "NP_808391", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808391", "type": "external" } ], "gene_names_uniprotkb": "Vsig8", "gene_names_refseq": "A030011M19; EG240916; Vsig8", "protein_names_uniprotkb": "V-set and immunoglobulin domain-containing protein 8", "protein_names_refseq": "V-set and immunoglobulin domain-containing protein 8 precursor; V-set and immunoglobulin domain-containing protein 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:240916)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21614015", "class_list": "", "function": "VSIG8 is found in the hair follicle, nails and oral cavity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6P3A4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6TAC4-1", "uniprot_id": [ { "id": "V2R26_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6TAC4", "type": "external" } ], "mass": 96200.0, "length": 855, "protein_name": "Vomeronasal type-2 receptor 26", "gene_name": "Vmn2r26", "organism": "Mouse", "refseq_name": "vomeronasal type-2 receptor 26 precursor", "refseq_ac": [ { "id": "NP_064301", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064301", "type": "external" } ], "gene_names_uniprotkb": "Vmn2r26; V2r1b", "gene_names_refseq": "V2R1; V2r1b; Vmn2r26", "protein_names_uniprotkb": "Vomeronasal type-2 receptor 26; Putative pheromone receptor V2R1b; Vomeronasal type-2 receptor 1b", "protein_names_refseq": "putative pheromone receptor V2R1b; tissue-type vomeronasal neurons putative pheromone receptor V2R1; vomeronasal 2, receptor, 1b; vomeronasal receptor Vmn2r26; vomeronasal type-2 receptor 1b; vomeronasal type-2 receptor 26 precursor; vomeronasal type-2 receptor 26", "tax_id": 10090, "disease": "", "pathway": " (mmu:56552)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12354396;19935653;21750661;9292726", "class_list": "", "function": "Putative pheromone receptor., [UniProtKB]; The peptide presentation system provided by MHC molecules co-evolves with the peptide recognition systems expressed by T cells and vomeronasal sensory neurons, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O70409", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0038022 G protein-coupled olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0030182 neuron differentiation;GO:0019236 response to pheromone", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6TAC4-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6ZQB6-1", "uniprot_id": [ { "id": "VIP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6ZQB6", "type": "external" } ], "mass": 128427.0, "length": 1129, "protein_name": "Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2", "gene_name": "Ppip5k2", "organism": "Mouse", "refseq_name": "inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform 11", "refseq_ac": [ { "id": "NP_776121", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776121", "type": "external" } ], "gene_names_uniprotkb": "Ppip5k2; Hisppd1; Kiaa0433; Vip2", "gene_names_refseq": "Cfap160; D330021B20; Hisppd1; Ppip5k2; Vip2; mKIAA0433", "protein_names_uniprotkb": "Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2; 2.7.4.24; Diphosphoinositol pentakisphosphate kinase 2; Histidine acid phosphatase domain-containing protein 1; InsP6 and PP-IP5 kinase 2; VIP1 homolog 2; mmVIP2", "protein_names_refseq": "VIP1 homolog 2; histidine acid phosphatase domain containing 1; histidine acid phosphatase domain-containing protein 1; inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform 11; inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2; insP6 and PP-IP5 kinase 2", "tax_id": 10090, "disease": "nonsyndromic deafness (Disease Ontology:DOID:0050563); autosomal recessive nonsyndromic deafness 100 (Disease Ontology:DOID:0111638); keratoconus (Disease Ontology:DOID:10126)", "pathway": " (mmu:227399); (R-MMU-1855167)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "17690096;19144319;21183079;21750661;29590114;31219806;34428180;39627609", "class_list": "", "function": "Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4 (PubMed:17690096). PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation (PubMed:17690096). Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4 (PubMed:17690096). Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 (PubMed:17690096). Required for normal hearing (PubMed:29590114)., [UniProtKB, PubMed, PubMed]; Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6)., [UniProtKB, UniProtKB]; Demonstration that PPIP5K2 has a role in hearing in humans indicates that PP-IP signaling is important to hair cell maintenance and function within inner ear Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9PVE9;Q3TM75;Q3UUA3;Q7TPU4", "ec_number_list": [ { "id": "2.7.4.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.24", "type": "external" } ], "go_molecular_function": "GO:0000827 inositol-1,3,4,5,6-pentakisphosphate kinase activity;GO:0000828 inositol hexakisphosphate kinase activity;GO:0000832 inositol hexakisphosphate 5-kinase activity;GO:0052723 inositol hexakisphosphate 1-kinase activity;GO:0033857 5-diphosphoinositol pentakisphosphate 1-kinase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006020 inositol metabolic process;GO:0007605 sensory perception of sound;GO:0032958 inositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q6ZQB6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q78T54-1", "uniprot_id": [ { "id": "VMA21_MOUSE", "url": "https://www.uniprot.org/uniprot/Q78T54", "type": "external" } ], "mass": 11365.0, "length": 101, "protein_name": "Vacuolar ATPase assembly integral membrane protein Vma21", "gene_name": "Vma21", "organism": "Mouse", "refseq_name": "vacuolar ATPase assembly integral membrane protein Vma21 isoform 2", "refseq_ac": [ { "id": "NP_001074825", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074825", "type": "external" } ], "gene_names_uniprotkb": "Vma21", "gene_names_refseq": "2610030H06Rik; Vma21", "protein_names_uniprotkb": "Vacuolar ATPase assembly integral membrane protein Vma21", "protein_names_refseq": "vacuolar ATPase assembly integral membrane protein Vma21 isoform 2; vacuolar ATPase assembly integral membrane protein Vma21", "tax_id": 10090, "disease": "X-linked myopathy with excessive autophagy (Disease Ontology:DOID:0050760); follicular lymphoma (Disease Ontology:DOID:0050873)", "pathway": " (mmu:67048)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16503986;21750661;25428507;25605945;34428180", "class_list": "", "function": "Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum., [UniProtKB, HAMAP, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UUC3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005764 lysosome;GO:0005789 endoplasmic reticulum membrane;GO:0012507 ER to Golgi transport vesicle membrane;GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane", "go_biological_process": "GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly;GO:0007042 lysosomal lumen acidification", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q78T54-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80TY5-1", "uniprot_id": [ { "id": "VP13B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80TY5", "type": "external" } ], "mass": 444015.0, "length": 3993, "protein_name": "Intermembrane lipid transfer protein VPS13B", "gene_name": "Vps13b", "organism": "Mouse", "refseq_name": "intermembrane lipid transfer protein VPS13B", "refseq_ac": [ { "id": "NP_796125", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796125", "type": "external" } ], "gene_names_uniprotkb": "Vps13b; Coh1; Kiaa0532", "gene_names_refseq": "1810042B05Rik; 2310042E16Rik; 4732488H20; C330002D13Rik; Coh1; D230005K13; Vps13b", "protein_names_uniprotkb": "Intermembrane lipid transfer protein VPS13B; Cohen syndrome protein 1 homolog; Vacuolar protein sorting-associated protein 13B", "protein_names_refseq": "cohen syndrome protein 1 homolog; intermembrane lipid transfer protein VPS13B; vacuolar protein sorting-associated protein 13B", "tax_id": 10090, "disease": "Cohen syndrome (Disease Ontology:DOID:0111590); cataract (Disease Ontology:DOID:83)", "pathway": " (mmu:666173)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;19006247;21750661;21952136;25428506;30084848;30779550;30962439;31218450;31219806;31495077;32915983;34203471;34428180;36210013", "class_list": "", "function": "Analysis of mouse tissues revealed ubiquitous expression of Coh1 homologous to human NM_152564 in all examined tissues but no prevalent alternative splicing., [RefSeq, PubMed]; Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Binds phosphatidylinositol 3-phosphate (PubMed:30962439). Functions as a tethering factor in the slow endocytic recycling pathway, to assist traffic between early and recycling endosomes (By similarity). Involved in the transport of proacrosomal vesicles to the nuclear dense lamina (NDL) during spermatid development (PubMed:31218450). Plays a role in the assembly of the Golgi apparatus, possibly by mediating trafficking to the Golgi membrane (By similarity). Plays a role in the development of the nervous system, and may be required for neuron projection development (PubMed:31495077). May also play a role during adipose tissue development (By similarity). Required for maintenance of the ocular lens (PubMed:32915983). Required for proper organization of the Golgi (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "E9QKX5", "ec_number_list": [], "go_molecular_function": "GO:0032266 phosphatidylinositol-3-phosphate binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0032588 trans-Golgi network membrane;GO:0005765 lysosomal membrane;GO:0031901 early endosome membrane;GO:0055038 recycling endosome membrane", "go_biological_process": "GO:0060323 head morphogenesis;GO:0006869 lipid transport;GO:0007399 nervous system development;GO:0007613 memory;GO:0060612 adipose tissue development", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q80TY5-1", "record_type": "protein", "filter_code": "0000000.1100111.001000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGF3-1", "uniprot_id": [ { "id": "DAA10_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGF3", "type": "external" } ], "mass": 39790.0, "length": 357, "protein_name": "Dynein axonemal assembly factor 10", "gene_name": "Dnaaf10", "organism": "Mouse", "refseq_name": "dynein axonemal assembly factor 10", "refseq_ac": [ { "id": "NP_849240", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_849240", "type": "external" } ], "gene_names_uniprotkb": "Dnaaf10; Wdr92", "gene_names_refseq": "Dnaaf10; HZGJ; Wdr92", "protein_names_uniprotkb": "Dynein axonemal assembly factor 10; WD repeat-containing protein 92; WD repeat-containing protein Monad", "protein_names_refseq": "WD repeat domain 92; WD repeat-containing protein 92; WD repeat-containing protein Monad; dynein axonemal assembly factor 10", "tax_id": 10090, "disease": "", "pathway": " (mmu:103784)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Key assembly factor specifically required for the stability of axonemal dynein heavy chains in cytoplasm., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0120293 dynein axonemal particle;GO:1990062 RPAP3/R2TP/prefoldin-like complex", "go_biological_process": "GO:0006915 apoptotic process;GO:0070286 axonemal dynein complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8BGF3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGW8-1", "uniprot_id": [ { "id": "VGLL2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGW8", "type": "external" } ], "mass": 34064.0, "length": 322, "protein_name": "Transcription cofactor vestigial-like protein 2", "gene_name": "Vgll2", "organism": "Mouse", "refseq_name": "transcription cofactor vestigial-like protein 2 isoform 2", "refseq_ac": [ { "id": "NP_001287886", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287886", "type": "external" } ], "gene_names_uniprotkb": "Vgll2; Vgl2; Vito1", "gene_names_refseq": "C130057C21Rik; VITO-1; Vgll2; Vito1; vgl-2", "protein_names_uniprotkb": "Transcription cofactor vestigial-like protein 2; Protein VITO1; Vgl-2", "protein_names_refseq": "transcription cofactor vestigial-like protein 2 isoform 2; transcription cofactor vestigial-like protein 2; vestigial like 2 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:215031)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12376544;14516696;14762206;15287000", "class_list": "", "function": "May act as a specific coactivator for the mammalian TEFs. May play a role in the development of skeletal muscles., [UniProtKB, PubMed]; This gene is a member of the Vestigial-like (Vgl) gene family and is upregulated during muscle differentiation. The product of this gene interacts with and modifies the DNA-binding properties of the transcription factor, TEF-1, and is important for muscle tissue development. Reduced expression of this gene leads to a reduction in the terminal differentiation of muscle cells. Alternate splicing results in multiple protein isoforms. [provided by RefSeq, Jul 2014]., [RefSeq]; VITO-1 is a crucial new cofactor of the muscle regulatory programme; VITO-1, a new scalloped interaction domain-containing protein, binds to TEF1 in vitro and strongly stimulates transcription of a reporter plasmid together with TEF-1 Publication Status: Online-Only, [RefSeq, PubMed]; Vestigial like 2 homolog is required for muscle gene expression, in part by switching DNA binding of TEF-1 factors during muscle differentiation. GeneRIF: A transcription cofactor required for skeletal muscle differentiation that modifies DNA target selectivity of the Transcriptional Enhancer Factor-1 (TEF-1) transcription factors., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BWB4", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007519 skeletal muscle tissue development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BGW8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C0M0-1", "uniprot_id": [ { "id": "WDR59_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C0M0", "type": "external" } ], "mass": 111726.0, "length": 992, "protein_name": "GATOR2 complex protein WDR59", "gene_name": "Wdr59", "organism": "Mouse", "refseq_name": "GATOR2 complex protein WDR59 isoform 3", "refseq_ac": [ { "id": "NP_001164213", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164213", "type": "external" } ], "gene_names_uniprotkb": "Wdr59; Cdw12; Kiaa1923", "gene_names_refseq": "5430401O09Rik; Cdw12; Wdr59", "protein_names_uniprotkb": "GATOR2 complex protein WDR59; CUL4- and DDB1-associated WDR protein 12; WD repeat-containing protein 59", "protein_names_refseq": "CUL4- and DDB1-associated WDR protein 12; GATOR complex protein WDR59; GATOR2 complex protein WDR59 isoform 3; GATOR2 complex protein WDR59; WD repeat-containing protein 59", "tax_id": 10090, "disease": "", "pathway": " (mmu:319481); (R-MMU-9639288)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;17041588;21183079;21750661;25428506;30084848;30779550;34203471;34428180", "class_list": "", "function": "As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway. The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex. GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1. In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation. In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9562, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TC49;Q3UWJ3;Q69Z65;Q6NZK7;Q8BLZ2;Q8BWK9", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005765 lysosomal membrane;GO:0005774 vacuolar membrane;GO:0061700 GATOR2 complex;GO:0035859 Seh1-associated complex", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0072659 protein localization to plasma membrane;GO:0045860 positive regulation of protein kinase activity;GO:0031669 cellular response to nutrient levels;GO:0034198 cellular response to amino acid starvation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8C0M0-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C0T0-1", "uniprot_id": [ { "id": "XKR8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C0T0", "type": "external" } ], "mass": 45563.0, "length": 401, "protein_name": "XK-related protein 8", "gene_name": "Xkr8", "organism": "Mouse", "refseq_name": "XK-related protein 8", "refseq_ac": [ { "id": "NP_958756", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_958756", "type": "external" } ], "gene_names_uniprotkb": "Xkr8", "gene_names_refseq": "4931440N07Rik; Gm1031; XRG8; Xkr8; mXkr8", "protein_names_uniprotkb": "XK-related protein 8; mXkr8", "protein_names_refseq": "X Kell blood group precursor related family member 8 homolog; XK-related protein 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:381560)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "23845944;25231987;27503893;28881496;29440417;30559640;30718401;31712393;34625749;37101210;37211968;38364890", "class_list": "", "function": "A dominant variant in apoptosis-related gene XKR8 is relevant to hereditary auditory neuropathy. Publication Status: Online-Only, [RefSeq, PubMed]; Findings show the Xk-family protein Xkr8 mediates phosphatidylserine exposure in response to apoptotic stimuli; Xk-family proteins have evolutionarily conserved roles in promoting phagocytosis of dying cells by altering the phospholipid distribution in the plasma membrane, [RefSeq, PubMed]; Phospholipid scramblase that promotes phosphatidylserine exposure on apoptotic cell surface (PubMed:23845944, PubMed:25231987, PubMed:27503893, PubMed:29440417, PubMed:30718401, PubMed:34625749, PubMed:37211968, PubMed:38364890). Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment (PubMed:23845944, PubMed:29440417, PubMed:30718401, PubMed:31712393, PubMed:34625749, PubMed:37211968, PubMed:38364890). Required for the clearance of apoptotic cells, such as engulfment of apoptotic germ cells by Sertoli cells, clearance of senescent neutrophils or regulation of bipolar cell numbers in the retina (PubMed:29440417, PubMed:30559640, PubMed:31712393). In the hippocampus, phosphatidylserine exposure also acts as a specific 'eat-me' marker for axon pruning during brain development (PubMed:37211968). Has no effect on calcium-induced exposure of phosphatidylserine (By similarity). Promotes myoblast differentiation and survival (PubMed:28881496)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The Xkr8 influences myogenesis by acting as a positive regulator of terminal differentiation and myoblast survival., [RefSeq, PubMed]; These results indicate that PtdSer exposure can be increased by the phosphorylation-mediated activation of Xkr8 scramblase and flippase down-regulation., [RefSeq, PubMed]; These results indicate that the Xkr8-mediated PtdSer exposure in apoptotic lymphocytes and aged neutrophils is essential for their clearance, and its defect activates the immune system, leading to lupus-like autoimmune disease., [RefSeq, PubMed]; Unlike Xkr8, which is ubiquitously expressed, Xkr4 and Xkr9 expression is tissue-specific., [RefSeq, PubMed]; Xkr8 (-/-) male mice were infertile due to reduced sperm counts in their epididymides. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 32, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0017128 phospholipid scramblase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0002513 tolerance induction to self antigen;GO:0043652 engulfment of apoptotic cell;GO:0097350 neutrophil clearance;GO:0098883 synapse pruning;GO:0045663 positive regulation of myoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8C0T0-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C5V5-1", "uniprot_id": [ { "id": "WDR27_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C5V5", "type": "external" } ], "mass": 86582.0, "length": 780, "protein_name": "WD repeat-containing protein 27", "gene_name": "Wdr27", "organism": "Mouse", "refseq_name": "WD repeat-containing protein 27", "refseq_ac": [ { "id": "NP_780382", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780382", "type": "external" } ], "gene_names_uniprotkb": "Wdr27", "gene_names_refseq": "0610012K18Rik; Wdr27", "protein_names_uniprotkb": "WD repeat-containing protein 27", "protein_names_refseq": "WD repeat-containing protein 27", "tax_id": 10090, "disease": "", "pathway": " (mmu:71682)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CA00", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8C5V5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C7V3-1", "uniprot_id": [ { "id": "UTP15_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C7V3", "type": "external" } ], "mass": 59375.0, "length": 528, "protein_name": "U3 small nucleolar RNA-associated protein 15 homolog", "gene_name": "Utp15", "organism": "Mouse", "refseq_name": "U3 small nucleolar RNA-associated protein 15 homolog", "refseq_ac": [ { "id": "NP_849249", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_849249", "type": "external" } ], "gene_names_uniprotkb": "Utp15", "gene_names_refseq": "Utp15", "protein_names_uniprotkb": "U3 small nucleolar RNA-associated protein 15 homolog; Src-associated protein SAW", "protein_names_refseq": "U3 small nucleolar RNA-associated protein 15 homolog; UTP15, U3 small nucleolar ribonucleoprotein, homolog; src-associated protein SAW", "tax_id": 10090, "disease": "", "pathway": " (mmu:105372); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "25428506", "class_list": "", "function": "Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TRG8;Q8K231", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0001650 fibrillar center;GO:0032040 small-subunit processome", "go_biological_process": "GO:2000234 positive regulation of rRNA processing;GO:0006351 DNA-templated transcription;GO:0006364 rRNA processing;GO:0045943 positive regulation of transcription by RNA polymerase I;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8C7V3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CCB4-1", "uniprot_id": [ { "id": "VPS53_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CCB4", "type": "external" } ], "mass": 94423.0, "length": 832, "protein_name": "Vacuolar protein sorting-associated protein 53 homolog", "gene_name": "Vps53", "organism": "Mouse", "refseq_name": "vacuolar protein sorting-associated protein 53 homolog isoform 1", "refseq_ac": [ { "id": "NP_080940", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080940", "type": "external" } ], "gene_names_uniprotkb": "Vps53", "gene_names_refseq": "2010002A08Rik; 2310040I21Rik; 3100002B05Rik; Hccs1; Vps53", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 53 homolog", "protein_names_refseq": "vacuolar protein sorting-associated protein 53 homolog isoform 1; vacuolar protein sorting-associated protein 53 homolog", "tax_id": 10090, "disease": "pontocerebellar hypoplasia type 2E (Disease Ontology:DOID:0060271)", "pathway": " (mmu:68299); (R-MMU-6811440)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;18511934;21183079;21750661;25605945;31219806;34428180", "class_list": "", "function": "Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as a component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Disruption of HCCS1 in mice leads to embryonic lethality, accompanied by abnormal labyrinth architecture resulting from the excessive proliferation of trophoblast cells in the placenta., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8C7U0;Q8CIA1;Q9CX82;Q9D6T7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000938 GARP complex;GO:1990745 EARP complex;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0006622 protein targeting to lysosome;GO:0042147 retrograde transport, endosome to Golgi;GO:0032456 endocytic recycling;GO:0007041 lysosomal transport;GO:0090119 vesicle-mediated cholesterol transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8CCB4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R0J7-1", "uniprot_id": [ { "id": "VP37B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R0J7", "type": "external" } ], "mass": 31056.0, "length": 285, "protein_name": "Vacuolar protein sorting-associated protein 37B", "gene_name": "Vps37b", "organism": "Mouse", "refseq_name": "vacuolar protein sorting-associated protein 37B", "refseq_ac": [ { "id": "NP_808544", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808544", "type": "external" } ], "gene_names_uniprotkb": "Vps37b", "gene_names_refseq": "2300007F24Rik; Vps37b", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 37B; ESCRT-I complex subunit VPS37B; Vps37B", "protein_names_refseq": "ESCRT-I complex subunit VPS37B; vacuolar protein sorting-associated protein 37B", "tax_id": 10090, "disease": "", "pathway": " (mmu:330192); (R-MMU-917729)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "26495903", "class_list": "", "function": "Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TLR2;Q3UDW1", "ec_number_list": [], "go_molecular_function": "GO:0048306 calcium-dependent protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0031902 late endosome membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0036258 multivesicular body assembly;GO:0039702 viral budding via host ESCRT complex;GO:1903774 positive regulation of viral budding via host ESCRT complex;GO:0006612 protein targeting to membrane;GO:0016236 macroautophagy", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8R0J7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R1C3-1", "uniprot_id": [ { "id": "VOPP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R1C3", "type": "external" } ], "mass": 19424.0, "length": 172, "protein_name": "WW domain binding protein VOPP1", "gene_name": "Vopp1", "organism": "Mouse", "refseq_name": "WW domain binding protein VOPP1 isoform a precursor", "refseq_ac": [ { "id": "NP_666280", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666280", "type": "external" } ], "gene_names_uniprotkb": "Vopp1; Ecop", "gene_names_refseq": "Ecop; Vopp1", "protein_names_uniprotkb": "WW domain binding protein VOPP1; ECop; EGFR-coamplified and overexpressed protein; Vesicular, overexpressed in cancer, prosurvival protein 1", "protein_names_refseq": "EGFR-coamplified and overexpressed protein; WW domain binding protein VOPP1 isoform a precursor; WW domain binding protein VOPP1", "tax_id": 10090, "disease": "", "pathway": " (mmu:232023)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Increases the transcriptional activity of NFKB1 by facilitating its nuclear translocation, DNA-binding and associated apoptotic response, when overexpressed. May sequester WWOX in lysosomal vesicles and thereby regulate WWOX role as tumor suppressor., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TZ79;Q8C0B7", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005768 endosome;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0030659 cytoplasmic vesicle membrane;GO:0031902 late endosome membrane", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8R1C3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R2E6-1", "uniprot_id": [ { "id": "V1A11_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R2E6", "type": "external" } ], "mass": 36003.0, "length": 318, "protein_name": "Vomeronasal type-1 receptor A11", "gene_name": "V1ra11", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "V1ra11", "gene_names_refseq": "", "protein_names_uniprotkb": "Vomeronasal type-1 receptor A11", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "11802169;12214233", "class_list": "", "function": "Putative pheromone receptor implicated in the regulation of social and reproductive behavior., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005550 pheromone binding;GO:0016503 pheromone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8R2E6-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VCG3-1", "uniprot_id": [ { "id": "WDR74_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VCG3", "type": "external" } ], "mass": 42636.0, "length": 384, "protein_name": "WD repeat-containing protein 74", "gene_name": "Wdr74", "organism": "Mouse", "refseq_name": "WD repeat-containing protein 74", "refseq_ac": [ { "id": "NP_598900", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598900", "type": "external" } ], "gene_names_uniprotkb": "Wdr74", "gene_names_refseq": "5730436H21Rik; Wdr74", "protein_names_uniprotkb": "WD repeat-containing protein 74", "protein_names_refseq": "WD repeat-containing protein 74", "tax_id": 10090, "disease": "", "pathway": " (mmu:107071)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21799883;35982296", "class_list": "", "function": "Regulatory protein of the MTREX-exosome complex involved in the synthesis of the 60S ribosomal subunit. Participates in an early cleavage of the pre-rRNA processing pathway in cooperation with NVL (By similarity). Required for blastocyst formation, is necessary for RNA transcription, processing and/or stability during preimplantation development (PubMed:21799883)., [UniProtKB, UniProtKB, PubMed]; WDR74 facilitates TGF-beta/Smad pathway activation to promote M2 macrophage polarization and diabetic foot ulcer wound healing in mice., [RefSeq, PubMed]; Wdr74 is required for RNA transcription, processing and/or stability during preimplantation development and is an essential gene in the mouse, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0030687 preribosome, large subunit precursor;GO:0000176 nuclear exosome (RNase complex)", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:0006364 rRNA processing;GO:0016070 RNA metabolic process;GO:0001825 blastocyst formation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8VCG3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VCY6-1", "uniprot_id": [ { "id": "UTP6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VCY6", "type": "external" } ], "mass": 70429.0, "length": 597, "protein_name": "U3 small nucleolar RNA-associated protein 6 homolog", "gene_name": "Utp6", "organism": "Mouse", "refseq_name": "U3 small nucleolar RNA-associated protein 6 homolog", "refseq_ac": [ { "id": "NP_659075", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659075", "type": "external" } ], "gene_names_uniprotkb": "Utp6; Mhat", "gene_names_refseq": "4732497O03Rik; HCA66; Utp6", "protein_names_uniprotkb": "U3 small nucleolar RNA-associated protein 6 homolog; Multiple hat domains protein", "protein_names_refseq": "U3 small nucleolar RNA-associated protein 6 homolog; UTP6, small subunit (SSU) processome component, homolog; hepatocellular carcinoma-associated antigen 66; multiple hat domains protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:216987); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "17380155;30059200;31219806;34428180;34887587;36210013", "class_list": "", "function": "Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA., [UniProtKB, UniProtKB]; Results suggest that reduced expression of HCA66, owing to haploinsufficiency of HCA66 gene, could render NF1 microdeleted patients-derived cells less susceptible to apoptosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8CH76", "ec_number_list": [], "go_molecular_function": "GO:0030515 snoRNA binding", "go_cellular_component": "GO:0034388 Pwp2p-containing subcomplex of 90S preribosome;GO:0005730 nucleolus;GO:0005694 chromosome;GO:0032040 small-subunit processome", "go_biological_process": "GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8VCY6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VEJ9-1", "uniprot_id": [ { "id": "VPS4A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VEJ9", "type": "external" } ], "mass": 48907.0, "length": 437, "protein_name": "Vacuolar protein sorting-associated protein 4A", "gene_name": "Vps4a", "organism": "Mouse", "refseq_name": "vacuolar protein sorting-associated protein 4A", "refseq_ac": [ { "id": "NP_569053", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_569053", "type": "external" } ], "gene_names_uniprotkb": "Vps4a", "gene_names_refseq": "4930589C15Rik; Vps4a", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 4A; 3.6.4.6", "protein_names_refseq": "vacuolar protein sorting protein 4a; vacuolar protein sorting-associated protein 4A", "tax_id": 10090, "disease": "attention deficit hyperactivity disorder (Disease Ontology:DOID:1094)", "pathway": " (mmu:116733); (R-MMU-917729); (R-MMU-9668328)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;12594041;30084848;33186545;34428180;37445978;37931722", "class_list": "", "function": "CHMP4B and VSP4A reverse GSDMD-mediated pyroptosis by cell membrane remodeling in endometrial carcinoma., [RefSeq, PubMed]; De Novo VPS4A Mutations Cause Multisystem Disease with Abnormal Neurodevelopment., [RefSeq, PubMed]; Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. It is required for proper accomplishment of various processes including the regulation of endosome size, primary cilium organization, mitotic spindle organization and chromosome segregation, and nuclear envelope sealing and spindle disassembly during anaphase (By similarity). In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. Involved in cytokinesis: retained at the midbody by ZFYVE19/ANCHR and CHMP4C until abscission checkpoint signaling is terminated at late cytokinesis. It is then released following dephosphorylation of CHMP4C, leading to abscission. VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). Critical for normal erythroblast cytokinesis and correct erythropoiesis (By similarity)., [UniProtKB, UniProtKB]; Vps4a Regulates Autophagic Flux to Prevent Hypertrophic Cardiomyopathy. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9718, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TXT2", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "5.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.1", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0044877 protein-containing complex binding;GO:0031267 small GTPase binding;GO:0140545 ATP-dependent protein disaggregase activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome", "go_biological_process": "GO:0001778 plasma membrane repair;GO:0031468 nuclear membrane reassembly;GO:0036258 multivesicular body assembly;GO:0039702 viral budding via host ESCRT complex;GO:0071985 multivesicular body sorting pathway", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8VEJ9-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VHI5-1", "uniprot_id": [ { "id": "VITRN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VHI5", "type": "external" } ], "mass": 70699.0, "length": 650, "protein_name": "Vitrin", "gene_name": "Vit", "organism": "Mouse", "refseq_name": "vitrin isoform 2", "refseq_ac": [ { "id": "NP_001183957", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001183957", "type": "external" } ], "gene_names_uniprotkb": "Vit; Akh", "gene_names_refseq": "1700052E02Rik; 1700110E08Rik; 2810429K11Rik; AKH; Vit; akhirin", "protein_names_uniprotkb": "Vitrin; Akhirin", "protein_names_refseq": "vitrin isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:74199)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;10830112;18757743;21750661;25331329;25428506;30084848;31599954;34428180;35820727", "class_list": "", "function": "Promotes matrix assembly and cell adhesiveness (PubMed:18757743). Plays a role in spinal cord formation by regulating the proliferation and differentiation of neural stem cells (PubMed:25331329)., [UniProtKB, PubMed, PubMed]; Promotes matrix assembly and cell adhesiveness. Plays a role in spinal cord formation by regulating the proliferation and differentiation of neural stem cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TZ47;Q8BQ41;Q8K047;Q9CYZ1", "ec_number_list": [], "go_molecular_function": "GO:0005539 glycosaminoglycan binding", "go_cellular_component": "GO:0031012 extracellular matrix;GO:0005614 interstitial matrix", "go_biological_process": "GO:0021510 spinal cord development;GO:0030198 extracellular matrix organization;GO:0010811 positive regulation of cell-substrate adhesion;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8VHI5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VIC7-1", "uniprot_id": [ { "id": "V1R45_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VIC7", "type": "external" } ], "mass": 36348.0, "length": 318, "protein_name": "Vomeronasal type-1 receptor 45", "gene_name": "Vmn1r45", "organism": "Mouse", "refseq_name": "vomeronasal type-1 receptor 45", "refseq_ac": [ { "id": "NP_035814", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035814", "type": "external" } ], "gene_names_uniprotkb": "Vmn1r45; Pr2; V1ra2; V1ra9", "gene_names_refseq": "V1RA9; V1r2; V1ra11; V1ra2; Vmn1r45; mV1R2", "protein_names_uniprotkb": "Vomeronasal type-1 receptor 45; Pheromone receptor 2; Vomeronasal type-1 receptor A2; Vomeronasal type-1 receptor A9; mV1R2", "protein_names_refseq": "pheromone receptor 2; vomeronasal 1 receptor Vmn1r45; vomeronasal 1 receptor, A2; vomeronasal 1, receptor 2; vomeronasal organ family 1, receptor 2; vomeronasal receptor 1 A9; vomeronasal receptor V1RA11; vomeronasal type-1 receptor 45; vomeronasal type-1 receptor A2; vomeronasal type-1 receptor A9", "tax_id": 10090, "disease": "", "pathway": " (mmu:22297)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12214233;21750661;9757043", "class_list": "", "function": "Putative pheromone receptor implicated in the regulation of social and reproductive behavior., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9Z196", "ec_number_list": [], "go_molecular_function": "GO:0005550 pheromone binding;GO:0016503 pheromone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8VIC7-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VIC9-1", "uniprot_id": [ { "id": "V1R43_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VIC9", "type": "external" } ], "mass": 37649.0, "length": 329, "protein_name": "Vomeronasal type-1 receptor 43", "gene_name": "Vmn1r43", "organism": "Mouse", "refseq_name": "vomeronasal type-1 receptor 43", "refseq_ac": [ { "id": "NP_444450", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444450", "type": "external" } ], "gene_names_uniprotkb": "Vmn1r43; V1ra2; V1ra5", "gene_names_refseq": "V1ra2; V1ra5; Vmn1r43", "protein_names_uniprotkb": "Vomeronasal type-1 receptor 43; Vomeronasal type-1 receptor A2; Vomeronasal type-1 receptor A5", "protein_names_refseq": "vomernasal 1 receptor Vmn1r43; vomeronasal receptor 1 A2; vomeronasal type-1 receptor 43; vomeronasal type-1 receptor A5", "tax_id": 10090, "disease": "", "pathway": " (mmu:113847)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11116090;12214233", "class_list": "", "function": "Putative pheromone receptor implicated in the regulation of social and reproductive behavior., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q05A91;Q9EQ50", "ec_number_list": [], "go_molecular_function": "GO:0005550 pheromone binding;GO:0016503 pheromone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8VIC9-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91V10-1", "uniprot_id": [ { "id": "VSX1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91V10", "type": "external" } ], "mass": 38755.0, "length": 363, "protein_name": "Visual system homeobox 1", "gene_name": "Vsx1", "organism": "Mouse", "refseq_name": "visual system homeobox 1", "refseq_ac": [ { "id": "NP_473409", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_473409", "type": "external" } ], "gene_names_uniprotkb": "Vsx1; Rinx", "gene_names_refseq": "CHX10-like; Vsx1", "protein_names_uniprotkb": "Visual system homeobox 1; Homeodomain protein RINX; Retinal inner nuclear layer homeobox protein; Transcription factor VSX1", "protein_names_refseq": "homeodomain protein RINX; retinal inner nuclear layer homeobox protein; transcription factor VSX1; visual system homeobox 1 homolog; visual system homeobox 1", "tax_id": 10090, "disease": "posterior polymorphous corneal dystrophy 1 (Disease Ontology:DOID:0110855); keratoconus (Disease Ontology:DOID:10126); corneal dystrophy (Disease Ontology:DOID:2566)", "pathway": " (mmu:114889)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11485319;11731243;14745032;15043821;15838724;17919464;20485683;30535423;31822965", "class_list": "", "function": "Binds to the 37-bp core of the locus control region (LCR) of the red/green visual pigment gene cluster (By similarity). May regulate the activity of the LCR and the cone opsin genes at earlier stages of development (By similarity). Dispensable in early retinal development (PubMed:17919464)., [UniProtKB, UniProtKB, PubMed]; Our results indicate that although VSX1 sequence variants can alter transcriptional activity, in the context of a mouse genetic model, at least one of these changes does not lead to corneal abnormalities. While we cannot exclude a role for VSX1 as a risk factor for corneal disease, on its own, it does not appear to play a major causative role., [RefSeq, PubMed]; Role in late differentiation and function of OFF-CB cells and is associated with a heritable OFF visual pathway-specific retinal defect, [RefSeq, PubMed]; Vsx1 and Chx10 paralogs sequentially secure V2 interneuron identity during spinal cord development., [RefSeq, PubMed]; Vsx1 is required for cone bipolar cell differentiation and regulates photopic vision perception., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000976 transcription cis-regulatory region binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0007601 visual perception;GO:0048666 neuron development;GO:0060040 retinal bipolar neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q91V10-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q920I9-1", "uniprot_id": [ { "id": "WDR7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q920I9", "type": "external" } ], "mass": 163450.0, "length": 1489, "protein_name": "WD repeat-containing protein 7", "gene_name": "Wdr7", "organism": "Mouse", "refseq_name": "WD repeat-containing protein 7 isoform 1", "refseq_ac": [ { "id": "NP_001014981", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014981", "type": "external" } ], "gene_names_uniprotkb": "Wdr7; Kiaa0541; Trag", "gene_names_refseq": "TRAG; Wdr7; mKIAA0541", "protein_names_uniprotkb": "WD repeat-containing protein 7; TGF-beta resistance-associated protein TRAG", "protein_names_refseq": "TGF-beta resistance associated; TGF-beta resistance-associated protein TRAG; WD repeat-containing protein 7 isoform 1; WD repeat-containing protein 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:104082)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;17242355;21183079;21750661;25605945;30084848;31219806;33300544;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q059Q1;Q3U440;Q80TY3;Q920J0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0002244 hematopoietic progenitor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q920I9-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q920R6-1", "uniprot_id": [ { "id": "VPP4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q920R6", "type": "external" } ], "mass": 95605.0, "length": 833, "protein_name": "V-type proton ATPase 116 kDa subunit a 4", "gene_name": "Atp6v0a4", "organism": "Mouse", "refseq_name": "V-type proton ATPase 116 kDa subunit a 4", "refseq_ac": [ { "id": "NP_536715", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_536715", "type": "external" } ], "gene_names_uniprotkb": "Atp6v0a4; Atp6n1b", "gene_names_refseq": "Atp6n1b; Atp6v0a4; a4", "protein_names_uniprotkb": "V-type proton ATPase 116 kDa subunit a 4; V-ATPase 116 kDa isoform a 4; V-type proton ATPase 116 kDa subunit a isoform 4; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 4; Vacuolar proton translocating ATPase 116 kDa subunit a kidney isoform", "protein_names_refseq": "ATPase, H+ transporting, lysosomal (vacuolar proton pump) noncatalytic accessory protein 1B; V-ATPase 116 kDa isoform a 4; V-ATPase 116 kDa; V-ATPase alpha 4; V-type proton ATPase 116 kDa subunit a 4; V-type proton ATPase 116 kDa subunit a; vacuolar proton translocating ATPase 100 kDa a4 subunit", "tax_id": 10090, "disease": "autosomal recessive distal renal tubular acidosis 3 with or without sensorineural hearing loss (Disease Ontology:DOID:0061166); autosomal recessive osteopetrosis 1 (Disease Ontology:DOID:0110942); renal tubular acidosis (Disease Ontology:DOID:14219); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:140494); (R-MMU-1222556); (R-MMU-77387); (R-MMU-917977); (R-MMU-983712)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "11495928;11498539;25428506;30084848;35988642", "class_list": "", "function": "Isoform a4 of the vacuolar ATPase a subunit promotes 4T1-12B breast cancer cell-dependent tumor growth and metastasis in vivo., [RefSeq, PubMed]; Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Involved in normal vectorial acid transport into the urine by the kidney (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CJ79;Q920B5", "ec_number_list": [], "go_molecular_function": "GO:0008553 P-type proton-exporting transporter activity;GO:0051117 ATPase binding;GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0005903 brush border;GO:0016323 basolateral plasma membrane;GO:0045177 apical part of cell", "go_biological_process": "GO:0007605 sensory perception of sound;GO:0001503 ossification;GO:0006885 regulation of pH;GO:0097254 renal tubular secretion;GO:0097401 synaptic vesicle lumen acidification", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q920R6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99ME2-1", "uniprot_id": [ { "id": "WDR6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99ME2", "type": "external" } ], "mass": 121898.0, "length": 1125, "protein_name": "tRNA (34-2'-O)-methyltransferase regulator WDR6", "gene_name": "Wdr6", "organism": "Mouse", "refseq_name": "tRNA (34-2'-O)-methyltransferase regulator WDR6", "refseq_ac": [ { "id": "NP_113569", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113569", "type": "external" } ], "gene_names_uniprotkb": "Wdr6", "gene_names_refseq": "Wdr6", "protein_names_uniprotkb": "tRNA (34-2'-O)-methyltransferase regulator WDR6; WD repeat-containing protein 6; mWDR6", "protein_names_refseq": "WD repeat-containing protein 6; tRNA (34-2'-O)-methyltransferase regulator WDR6", "tax_id": 10090, "disease": "", "pathway": " (mmu:83669); (R-MMU-9013420); (R-MMU-9013424); (R-MMU-9696264); (R-MMU-9696270); (R-MMU-9696273)", "pathway_count": 6, "publication_count": 8, "publication_id_list": "22872234;25428506;30779550;31219806;32152506;34203471;34428180;36210013", "class_list": "", "function": "Together with methyltransferase FTSJ1, methylates the 2'-O-ribose of nucleotides at position 34 of the tRNA anticodon loop of substrate tRNAs (By similarity). Required for the correct positioning of the substrate tRNA for methylation (By similarity). Required to suppress amino acid starvation-induced autophagy (By similarity). Enhances the STK11/LKB1-induced cell growth suppression activity (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000049 tRNA binding;GO:0030234 enzyme regulator activity;GO:0043560 insulin receptor substrate binding;GO:0140767 enzyme-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0032991 protein-containing complex;GO:0008180 COP9 signalosome", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0010507 negative regulation of autophagy;GO:0030488 tRNA methylation;GO:0070314 G1 to G0 transition;GO:0002130 wobble position ribose methylation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q99ME2-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CR27-1", "uniprot_id": [ { "id": "WASC3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CR27", "type": "external" } ], "mass": 21093.0, "length": 194, "protein_name": "WASH complex subunit 3", "gene_name": "Washc3", "organism": "Mouse", "refseq_name": "WASH complex subunit 3 isoform 2", "refseq_ac": [ { "id": "NP_001116432", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116432", "type": "external" } ], "gene_names_uniprotkb": "Washc3; Ccdc53", "gene_names_refseq": "2900091E11Rik; 5730495F03Rik; Ccdc53; Washc3", "protein_names_uniprotkb": "WASH complex subunit 3; Coiled-coil domain-containing protein 53", "protein_names_refseq": "WASH complex subunit 3 isoform 2; WASH complex subunit CCDC53; coiled-coil domain containing 53; coiled-coil domain-containing protein 53", "tax_id": 10090, "disease": "", "pathway": " (mmu:67282)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "19224205;20173027;21750661;25428506;30084848;30779550;34428180", "class_list": "", "function": "Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sortingg., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K2X5;Q9D0Y7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0031901 early endosome membrane;GO:0071203 WASH complex", "go_biological_process": "GO:0015031 protein transport;GO:0016197 endosomal transport;GO:0030041 actin filament polymerization;GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation;GO:0006887 exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9CR27-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CX97-1", "uniprot_id": [ { "id": "WDR55_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CX97", "type": "external" } ], "mass": 42611.0, "length": 388, "protein_name": "WD repeat-containing protein 55", "gene_name": "Wdr55", "organism": "Mouse", "refseq_name": "WD repeat-containing protein 55", "refseq_ac": [ { "id": "NP_080740", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080740", "type": "external" } ], "gene_names_uniprotkb": "Wdr55", "gene_names_refseq": "2410080P20Rik; Wdr55", "protein_names_uniprotkb": "WD repeat-containing protein 55", "protein_names_refseq": "WD repeat-containing protein 55", "tax_id": 10090, "disease": "", "pathway": " (mmu:67936)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "18769712;21750661;22872234;25428506;30084848;30779550;34428180", "class_list": "", "function": "Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2RS10", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9CX97-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CZJ1-1", "uniprot_id": [ { "id": "UTP11_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CZJ1", "type": "external" } ], "mass": 30551.0, "length": 253, "protein_name": "Probable U3 small nucleolar RNA-associated protein 11", "gene_name": "Utp11", "organism": "Mouse", "refseq_name": "probable U3 small nucleolar RNA-associated protein 11 isoform a", "refseq_ac": [ { "id": "NP_080307", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080307", "type": "external" } ], "gene_names_uniprotkb": "Utp11; Utp11l", "gene_names_refseq": "2700082D03Rik; CGI-94; Cgi94; Utp11l; Utp11", "protein_names_uniprotkb": "Probable U3 small nucleolar RNA-associated protein 11; U3 snoRNA-associated protein 11; UTP11-like protein", "protein_names_refseq": "U3 snoRNA-associated protein 11; UTP11-like protein; UTP11-like, U3 small nucleolar ribonucleoprotein; probable U3 small nucleolar RNA-associated protein 11 isoform a; probable U3 small nucleolar RNA-associated protein 11", "tax_id": 10090, "disease": "", "pathway": " (mmu:67205); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "31599954", "class_list": "", "function": "Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UI21;Q9CVB5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0007399 nervous system development;GO:0043065 positive regulation of apoptotic process;GO:0006364 rRNA processing;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CZJ1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D1C8-1", "uniprot_id": [ { "id": "VPS28_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D1C8", "type": "external" } ], "mass": 25452.0, "length": 221, "protein_name": "Vacuolar protein sorting-associated protein 28 homolog", "gene_name": "Vps28", "organism": "Mouse", "refseq_name": "vacuolar protein sorting-associated protein 28 homolog isoform 2", "refseq_ac": [ { "id": "NP_001292597", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001292597", "type": "external" } ], "gene_names_uniprotkb": "Vps28", "gene_names_refseq": "1110014J03Rik; CIIA; D730005C08Rik; Vps28", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 28 homolog; CIIA; Caspase-activated DNase inhibitor that interacts with ASK1; ESCRT-I complex subunit VPS28", "protein_names_refseq": "ESCRT-I complex subunit VPS28; caspase-activated DNase inhibitor that interacts with ASK1; vacuolar protein sorting-associated protein 28 homolog isoform 2; vacuolar protein sorting-associated protein 28 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:66914); (R-MMU-917729)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "14557248;21750661;22042618;25098452;26740625;30084848;34428180", "class_list": "", "function": "CIIA attenuates neurotoxicity caused by OGD/R through inhibiting ASK1-dependent signaling events., [RefSeq, PubMed]; CIIA functions as a molecular switch for the GEF activity of SOS1, directing this activity toward Rac1., [RefSeq, PubMed]; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process., [UniProtKB, UniProtKB]; Component of the ESCRT-I complex, a regulator of vesicular trafficking process., [UniProtKB]; This gene encodes a protein which is thought to be a subunit of the ESCRT-I complex (endosomal complexes required for transport), which functions in the transport and sorting of proteins into subcellular vesicles. This complex can also be hijacked to facilitate the budding of enveloped viruses from the cell membrane. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:2000397 positive regulation of ubiquitin-dependent endocytosis;GO:0045732 positive regulation of protein catabolic process;GO:0031397 negative regulation of protein ubiquitination;GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9D1C8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D529-1", "uniprot_id": [ { "id": "WBP2L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D529", "type": "external" } ], "mass": 37485.0, "length": 359, "protein_name": "Postacrosomal sheath WW domain-binding protein", "gene_name": "Wbp2nl", "organism": "Mouse", "refseq_name": "postacrosomal sheath WW domain-binding protein", "refseq_ac": [ { "id": "NP_083342", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083342", "type": "external" } ], "gene_names_uniprotkb": "Wbp2nl; Pawp", "gene_names_refseq": "4930521I23Rik; PAWP; Wbp2nl", "protein_names_uniprotkb": "Postacrosomal sheath WW domain-binding protein; WW domain-binding protein 2-like", "protein_names_refseq": "WW domain-binding protein 2-like; postacrosomal sheath WW domain-binding protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:74716)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17289678;17988661;24381051;25057041;25428506;26377222", "class_list": "", "function": "May play a role in meiotic resumption and pronuclear formation, mediated by a WW domain-signaling pathway during fertilization., [UniProtKB]; PAWP does not play an essential role in mouse fertilization, [RefSeq, PubMed]; The data suggest that sperm-derived PAWP is not involved in triggering Ca(2+) oscillations at fertilization in mammalian oocytes., [RefSeq, PubMed]; The postacrosomal assembly of sperm head protein, PAWP, is independent of acrosome formation and dependent on microtubular manchette transport, [RefSeq, PubMed]; These results indicate that PAWP plays a role in spermatogenesis and germ cell development. Moreover, we suggest PAWP as one of the markers that could be looked in ESC studies as a confirmed testis-specific gene, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0050699 WW domain binding;GO:0031490 chromatin DNA binding", "go_cellular_component": "GO:0061827 sperm head;GO:0005634 nucleus;GO:0036126 sperm flagellum;GO:0033011 perinuclear theca", "go_biological_process": "GO:0045893 positive regulation of DNA-templated transcription;GO:0035038 female pronucleus assembly;GO:0035039 male pronucleus assembly;GO:0007343 egg activation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9D529-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D7H2-1", "uniprot_id": [ { "id": "WDR5B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D7H2", "type": "external" } ], "mass": 36033.0, "length": 328, "protein_name": "WD repeat-containing protein 5B", "gene_name": "Wdr5b", "organism": "Mouse", "refseq_name": "WD repeat-containing protein 5B", "refseq_ac": [ { "id": "NP_081389", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081389", "type": "external" } ], "gene_names_uniprotkb": "Wdr5b", "gene_names_refseq": "2310009C03Rik; Wdr5b", "protein_names_uniprotkb": "WD repeat-containing protein 5B", "protein_names_refseq": "WD repeat-containing protein 5B", "tax_id": 10090, "disease": "congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (mmu:69544)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17041588;34428180", "class_list": "", "function": "Plays a role in the proliferation of retinal pigment epithelial (RPE) cells (By similarity). May function as a substrate receptor for CUL4-DDB1 ubiquitin E3 ligase complex., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0048188 Set1C/COMPASS complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D7H2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EP51-1", "uniprot_id": [ { "id": "V1R50_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EP51", "type": "external" } ], "mass": 35195.0, "length": 310, "protein_name": "Vomeronasal type-1 receptor 50", "gene_name": "Vmn1r50", "organism": "Mouse", "refseq_name": "vomeronasal type-1 receptor 50", "refseq_ac": [ { "id": "NP_444455", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444455", "type": "external" } ], "gene_names_uniprotkb": "Vmn1r50; V1ra5; V1rb1", "gene_names_refseq": "V1RA5; V1rb1; VN2; Vmn1r50", "protein_names_uniprotkb": "Vomeronasal type-1 receptor 50; Pheromone receptor VN2; Vomeronasal receptor 2; Vomeronasal type-1 receptor A5; Vomeronasal type-1 receptor B1", "protein_names_refseq": "pheromone receptor VN2; vomernasal 1 receptor Vmn1r50; vomeronasal 1 receptor, B1; vomeronasal receptor 1 A5; vomeronasal receptor 2; vomeronasal type 1 receptor B1; vomeronasal type-1 receptor 50; vomeronasal type-1 receptor A5", "tax_id": 10090, "disease": "", "pathway": " (mmu:113852)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11116090;11752409;12214233;16731509", "class_list": "", "function": "Inputs from neurons in vomeronasal organ expressing closely related V1Rs intermingle within shared, spatially conserved domains of the accessory olfactory bulb (AOB), [RefSeq, PubMed]; Putative pheromone receptor implicated in the regulation of social and reproductive behavior., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8VIC3", "ec_number_list": [], "go_molecular_function": "GO:0005550 pheromone binding;GO:0016503 pheromone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9EP51-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EP93-1", "uniprot_id": [ { "id": "V1R53_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EP93", "type": "external" } ], "mass": 35399.0, "length": 310, "protein_name": "Vomeronasal type-1 receptor 53", "gene_name": "Vmn1r53", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Vmn1r53; V1rb3", "gene_names_refseq": "", "protein_names_uniprotkb": "Vomeronasal type-1 receptor 53; Pheromone receptor VN5; Vomeronasal receptor 5; Vomeronasal type-1 receptor B3", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "11116090;11752409;12214233", "class_list": "", "function": "Putative pheromone receptor implicated in the regulation of social and reproductive behavior., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q059M1", "ec_number_list": [], "go_molecular_function": "GO:0005550 pheromone binding;GO:0016503 pheromone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9EP93-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQ46-1", "uniprot_id": [ { "id": "V1R40_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EQ46", "type": "external" } ], "mass": 35207.0, "length": 310, "protein_name": "Vomeronasal type-1 receptor 40", "gene_name": "Vmn1r40", "organism": "Mouse", "refseq_name": "vomeronasal type-1 receptor 40", "refseq_ac": [ { "id": "NP_444458", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444458", "type": "external" } ], "gene_names_uniprotkb": "Vmn1r40; V1ra11; V1rb7", "gene_names_refseq": "V1rb7; Vmn1r40", "protein_names_uniprotkb": "Vomeronasal type-1 receptor 40; Vomeronasal type-1 receptor A11; Vomeronasal type-1 receptor B7", "protein_names_refseq": "vomernasal 1 receptor Vmn1r40; vomeronasal 1 receptor, B7; vomeronasal type 1 receptor B7; vomeronasal type-1 receptor 40; vomeronasal type-1 receptor A11", "tax_id": 10090, "disease": "", "pathway": " (mmu:113855)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11116090;12214233;21750661", "class_list": "", "function": "Putative pheromone receptor implicated in the regulation of social and reproductive behavior., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005550 pheromone binding;GO:0016503 pheromone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9EQ46-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQ52-1", "uniprot_id": [ { "id": "V1R48_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EQ52", "type": "external" } ], "mass": 34263.0, "length": 302, "protein_name": "Vomeronasal type-1 receptor 48", "gene_name": "Vmn1r48", "organism": "Mouse", "refseq_name": "vomeronasal type-1 receptor 48", "refseq_ac": [ { "id": "NP_444448", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444448", "type": "external" } ], "gene_names_uniprotkb": "Vmn1r48; V1ra3; V1ra6", "gene_names_refseq": "V1ra3; Vmn1r48", "protein_names_uniprotkb": "Vomeronasal type-1 receptor 48; Vomeronasal type-1 receptor A3; Vomeronasal type-1 receptor A6", "protein_names_refseq": "vomernasal 1 receptor Vmn1r48; vomeronasal 1 receptor, A3; vomeronasal type-1 receptor 48; vomeronasal type-1 receptor A3; vomeronasal type-1 receptor A6", "tax_id": 10090, "disease": "", "pathway": " (mmu:113845)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11116090;12214233;31219806", "class_list": "", "function": "Putative pheromone receptor implicated in the regulation of social and reproductive behavior., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005550 pheromone binding;GO:0016503 pheromone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9EQ52-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QXY7-1", "uniprot_id": [ { "id": "XK_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QXY7", "type": "external" } ], "mass": 51115.0, "length": 446, "protein_name": "Endoplasmic reticulum membrane adapter protein XK", "gene_name": "Xk", "organism": "Mouse", "refseq_name": "endoplasmic reticulum membrane adapter protein XK", "refseq_ac": [ { "id": "NP_075989", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075989", "type": "external" } ], "gene_names_uniprotkb": "Xk; Xkh; Xkr1; Xrg1", "gene_names_refseq": "1810038K19Rik; XRG1; Xkh; Xk", "protein_names_uniprotkb": "Endoplasmic reticulum membrane adapter protein XK; Membrane transport protein XK; XK homolog; XK-related protein 1", "protein_names_refseq": "Kell blood group precursor (McLeod phenotype) homolog; McLeod syndrome gene homolog; XK homolog; XK-related protein 1; endoplasmic reticulum membrane adapter protein XK; membrane transport protein XK", "tax_id": 10090, "disease": "McLeod syndrome (Disease Ontology:DOID:0112107); hematopoietic system disease (Disease Ontology:DOID:74)", "pathway": " (mmu:22439); (R-MMU-375276)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10541802;11132157;25231987;31599954;36099524", "class_list": "", "function": "Impaired XK recycling for importing manganese underlies striatal vulnerability in Huntington's disease., [RefSeq, PubMed]; Recruits the lipid transfer protein VPS13A from lipid droplets to the endoplasmic reticulum (ER) membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006874 intracellular calcium ion homeostasis;GO:0042552 myelination;GO:0048741 skeletal muscle fiber development;GO:0006865 amino acid transport;GO:0010961 intracellular magnesium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9QXY7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZ25-1", "uniprot_id": [ { "id": "VNN3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QZ25", "type": "external" } ], "mass": 56305.0, "length": 500, "protein_name": "Vascular non-inflammatory molecule 3", "gene_name": "Vnn3", "organism": "Mouse", "refseq_name": "vascular non-inflammatory molecule 3 precursor", "refseq_ac": [ { "id": "NP_036109", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036109", "type": "external" } ], "gene_names_uniprotkb": "Vnn3", "gene_names_refseq": "Vnn3", "protein_names_uniprotkb": "Vascular non-inflammatory molecule 3; Vanin-3", "protein_names_refseq": "vascular non-inflammatory molecule 3 precursor; vascular non-inflammatory molecule 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:26464)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10501839;11491533;17312006;23386199", "class_list": "", "function": "Lack of pantetheinase protein activity in tissues is associated with susceptibility to malaria and is linked to a complex rearrangement in the Vnn3 promoter region., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "E9QMT9", "ec_number_list": [], "go_molecular_function": "GO:0017159 pantetheine hydrolase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0015939 pantothenate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9QZ25-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZQ3-1", "uniprot_id": [ { "id": "UTS2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QZQ3", "type": "external" } ], "mass": 13625.0, "length": 123, "protein_name": "Urotensin-2", "gene_name": "Uts2", "organism": "Mouse", "refseq_name": "urotensin-2 preproprotein", "refseq_ac": [ { "id": "NP_036040", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036040", "type": "external" } ], "gene_names_uniprotkb": "Uts2; Ucn2", "gene_names_refseq": "UII; Ucn2; Uts2; prepro-UII", "protein_names_uniprotkb": "Urotensin-2; U-II; UII; Urotensin II", "protein_names_refseq": "urotensin-2 preproprotein; urotensin-II", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); heart disease (Disease Ontology:DOID:114); gestational diabetes (Disease Ontology:DOID:11714); endomyocardial fibrosis (Disease Ontology:DOID:12932); asthma (Disease Ontology:DOID:2841); carotid artery disease (Disease Ontology:DOID:3407); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); diabetic retinopathy (Disease Ontology:DOID:8947); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:24111); (R-MMU-375276); (R-MMU-416476)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10486557;16160878;16361078;18710417;18806619;27448985;29133126;31238319;36892588", "class_list": "", "function": "17 amino acid seq and effects on body temperature, water and food consumption, locomotion, exploratory behavior, etc., [RefSeq, PubMed]; Highly potent vasoconstrictor., [UniProtKB]; IRF3 expression and activation depend on the signal transduction of the the urotensin II/urotensin receptor (UII/UT) system, and play important roles in UII/UT-mediated immune inflammatory injury in the liver, [RefSeq, PubMed]; In the CNS UII mRNAs are expressed in brainstem and spinal motoneurons, also expressed in the medial vestibular nucleus, locus coeruleus and the ventral medulla., [RefSeq, PubMed]; Increased plasma urotensin II level stimulates oxidized low-density lipoprotein and reactive oxygen species production and macrophage foam cell formation, [RefSeq, PubMed]; Mouse UII is expressed in a subpopulation of motoneurons in the spinal cord, [RefSeq, PubMed]; Role of urotensin-II and its receptors in sepsis-induced lung injury under diabetic conditions, [RefSeq, PubMed]; This gene encodes a member of the urotensin family of peptide hormones. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional hormone before secretion into the plasma. Mice lacking the encoded protein have a significantly decreased low density lipoprotein cholesterol profile and hepatic steatosis that is consistent with decreased hepatocyte de novo cholesterol synthesis and apolipoprotein B secretion. [provided by RefSeq, Sep 2016]., [RefSeq]; UII induces mice skeletal muscle atrophy associated with enhanced skeletal muscle autophagy and inhibited FNDC5 expression in chronic renal failure., [RefSeq, PubMed]; Urotensin II can Induce Skeletal Muscle Atrophy Associated with Upregulating Ubiquitin-Proteasome System and Inhibiting the Differentiation of Satellite Cells in CRF Mice., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0032224 positive regulation of synaptic transmission, cholinergic;GO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0045777 positive regulation of blood pressure;GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9QZQ3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0M1-1", "uniprot_id": [ { "id": "XCR1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R0M1", "type": "external" } ], "mass": 37308.0, "length": 322, "protein_name": "Chemokine XC receptor 1", "gene_name": "Xcr1", "organism": "Mouse", "refseq_name": "chemokine XC receptor 1", "refseq_ac": [ { "id": "NP_035928", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035928", "type": "external" } ], "gene_names_uniprotkb": "Xcr1; Ccxcr1", "gene_names_refseq": "Ccxcr1; Gpr5; Xcr1; mXcr1", "protein_names_uniprotkb": "Chemokine XC receptor 1; Lymphotactin receptor; SCM1 receptor; XC chemokine receptor 1; mXCR1", "protein_names_refseq": "C motif-1/lymphotactin receptor; SCM1 receptor; XC chemokine receptor 1; chemokine (C motif) XC receptor 1; chemokine XC receptor 1; lymphotactin receptor", "tax_id": 10090, "disease": "", "pathway": " (mmu:23832); (R-MMU-380108); (R-MMU-416476)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10518929;20479118;20541533;21300913;34428180", "class_list": "", "function": "Receptor for chemokines SCYC1 and SCYC2. Subsequently transduces a signal by increasing the intracellular calcium ions level. Receptor for XCL1/Lymphotactin (Probable)., [UniProtKB, PubMed]; The expression patterns of XCR1 and XCL1 were conserved in human and mice blood cells, including certain dendritic cell subsets., [RefSeq, PubMed]; XCR1 constitutes the first conserved specific marker for cell subsets homologous to mouse CD8alpha+ dendritic cells in higher vertebrates., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016493 C-C chemokine receptor activity;GO:0019957 C-C chemokine binding", "go_cellular_component": "GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006935 chemotaxis;GO:0006955 immune response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0019722 calcium-mediated signaling;GO:0034097 response to cytokine", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9R0M1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WUF1-1", "uniprot_id": [ { "id": "V1R49_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WUF1", "type": "external" } ], "mass": 35523.0, "length": 310, "protein_name": "Vomeronasal type-1 receptor 49", "gene_name": "Vmn1r49", "organism": "Mouse", "refseq_name": "vomeronasal type-1 receptor 49", "refseq_ac": [ { "id": "NP_036041", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036041", "type": "external" } ], "gene_names_uniprotkb": "Vmn1r49; V1rb2", "gene_names_refseq": "V1r5; V1rb2; VRi2; Vmn1r49", "protein_names_uniprotkb": "Vomeronasal type-1 receptor 49; Vomeronasal receptor VRi2; Vomeronasal type-1 receptor B2", "protein_names_refseq": "vomeronasal 1 receptor Vmn1r49; vomeronasal 1, receptor B2; vomeronasal organ family 1, receptor 5; vomeronasal organ family 1, receptor B2; vomeronasal receptor VRi2; vomeronasal type 1 receptor B2; vomeronasal type-1 receptor 49", "tax_id": 10090, "disease": "", "pathway": " (mmu:24112)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10219241;11116090;12214233;19200072", "class_list": "", "function": "Putative pheromone receptor implicated in the regulation of social and reproductive behavior., [UniProtKB, PubMed, PubMed]; We show, in vivo, that the genetic replacement of the V1rb2 pheromone receptor coding sequence by an unrelated one from the odorant receptor gene M71 maintains gene exclusion, suggesting that a common mechanism is used to regulate their transcription., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005550 pheromone binding;GO:0016503 pheromone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9WUF1-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WV55-1", "uniprot_id": [ { "id": "VAPA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WV55", "type": "external" } ], "mass": 27855.0, "length": 249, "protein_name": "Vesicle-associated membrane protein-associated protein A", "gene_name": "Vapa", "organism": "Mouse", "refseq_name": "vesicle-associated membrane protein-associated protein A isoform 2", "refseq_ac": [ { "id": "NP_038961", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038961", "type": "external" } ], "gene_names_uniprotkb": "Vapa; Vap33", "gene_names_refseq": "33kDa; VAMP-A; VAP-33; VAP-A; VAP33; Vapa", "protein_names_uniprotkb": "Vesicle-associated membrane protein-associated protein A; 33 kDa VAMP-associated protein; VAMP-A; VAMP-associated protein A; VAP-33; VAP-A", "protein_names_refseq": "33 kDa VAMP-associated protein; VAMP-associated protein A; synaptobrevin-associated protein of 33kDa; vesicle-associated membrane protein-associated protein A isoform 2", "tax_id": 10090, "disease": "amyotrophic lateral sclerosis type 8 (Disease Ontology:DOID:0050752); autosomal dominant adult-onset proximal spinal muscular atrophy (Disease Ontology:DOID:0111194); neurodegenerative disease (Disease Ontology:DOID:1289); motor neuron disease (Disease Ontology:DOID:231); amyotrophic lateral sclerosis (Disease Ontology:DOID:332)", "pathway": " (mmu:30960); (R-MMU-6798695); (R-MMU-9609523)", "pathway_count": 3, "publication_count": 22, "publication_id_list": "10.1101/2023.09.13.557529;10655491;15212954;19144319;21540332;21750661;22645316;24251978;24788674;25428506;25605945;28135057;28528544;29187734;30012696;31219806;31594866;32152506;32525583;32734583;34428180;39927985", "class_list": "", "function": "CALCOCO1 acts with VAMP-associated proteins to mediate ER-phagy., [RefSeq, PubMed]; Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44. STARD3-VAPA interaction enables cholesterol transfer from the ER to endosomes. Via interaction with WDR44 participates in neosynthesized protein export. In addition, recruited to the plasma membrane through OSBPL3 binding. The OSBPL3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; ORP/Osh mediate cross-talk between ER-plasma membrane contact site components and plasma membrane SNAREs., [RefSeq, PubMed]; The VAP-interacting membrane-associated phosphatidylinositol (PtdIns) transfer proteins PYK2 N-terminal domain-interacting receptor 2 (Nir2) and Nir3 specifically associate with Kv2.1 complexes., [RefSeq, PubMed]; There was colocalization of Kv2.1 and Kv2.2 with endogenous VAPA at ER-PM junctions in mouse brain neurons. Expression of Kv2.1 recruits VAPA to ER-PM junctions. Knocking out VAPA expression disrupts Kv2.1 clustering.The domains of VAPs and Kv2.1 necessary and sufficient for their association at ER-PM junctions were identified., [RefSeq, PubMed]; Vapa regulates partitioning of Osbp between the endoplasmic retiuculum and the Golgi apparatus., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJM1;Q9QY77", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0016020 membrane", "go_biological_process": "GO:0006686 sphingomyelin biosynthetic process;GO:0044829 host-mediated activation of viral genome replication;GO:0031175 neuron projection development;GO:0035627 ceramide transport;GO:0015914 phospholipid transport", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q9WV55-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A075B5R7-1", "uniprot_id": [ { "id": "A0A075B5R7_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A075B5R7", "type": "external" } ], "mass": 13002.0, "length": 117, "protein_name": "Immunoglobulin heavy variable 14-2", "gene_name": "Ighv14-2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ighv14-2", "gene_names_refseq": "", "protein_names_uniprotkb": "Immunoglobulin heavy variable 14-2", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-173623); (R-MMU-198933); (R-MMU-202733); (R-MMU-2029481); (R-MMU-2029482); (R-MMU-2029485); (R-MMU-2168880); (R-MMU-2454202); (R-MMU-2730905); (R-MMU-2871796); (R-MMU-2871809); (R-MMU-2871837); (R-MMU-5690714); (R-MMU-977606); (R-MMU-983695)", "pathway_count": 15, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0016064 immunoglobulin mediated immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A075B5R7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A075B5S6-1", "uniprot_id": [ { "id": "A0A075B5S6_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A075B5S6", "type": "external" } ], "mass": 13109.0, "length": 116, "protein_name": "Immunoglobulin heavy variable 3-1", "gene_name": "Ighv3-1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ighv3-1", "gene_names_refseq": "", "protein_names_uniprotkb": "Immunoglobulin heavy variable 3-1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-173623); 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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Znf462", "organism": "Mouse", "refseq_name": "zinc finger protein 462", "refseq_ac": [ { "id": "NP_766455", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766455", "type": "external" } ], "gene_names_uniprotkb": "Zfp462; Znf462; Zfp462", "gene_names_refseq": "6030417H05; 9430078C22Rik; Gt4-2; Zfp462; Zfpip; Znf462", "protein_names_uniprotkb": "Zinc finger protein 462; ZFPIP; Zinc finger PBX1-interacting protein", "protein_names_refseq": "gene trap insertion site 4-2; zinc finger PBX1-interacting protein; zinc finger protein 462", "tax_id": 10090, "disease": "generalized anxiety disorder (Disease Ontology:DOID:14320)", "pathway": " (mmu:242466)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "17207666;17353115;20219459;21570965;21750661;27621227;30059200;34428180;36604593;37817032", "class_list": "", "function": "MiR-377-3p Regulates Hippocampal Neurogenesis via the Zfp462-Pbx1 Pathway and Mediates Anxiety-Like Behaviors in Prenatal Hypoxic Offspring., [RefSeq, PubMed]; ZFP462 safeguards neural lineage specification by targeting G9A/GLP-mediated heterochromatin to silence enhancers., [RefSeq, PubMed]; Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organization (PubMed:20219459, PubMed:21570965). Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG (PubMed:21570965). By binding PBX1, prevents the heterodimerization of PBX1 and HOXA9 and their binding to DNA (PubMed:17353115). Regulates neuronal development and neural cell differentiation (PubMed:21570965, PubMed:27621227)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2SW42", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "B1AWL2-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3YVL2-1", "uniprot_id": [ { "id": "CFA70_MOUSE", "url": "https://www.uniprot.org/uniprot/D3YVL2", "type": "external" } ], "mass": 128276.0, "length": 1141, "protein_name": "Cilia- and flagella-associated protein 70", "gene_name": "Cfap70", "organism": "Mouse", "refseq_name": "cilia- and flagella-associated protein 70 isoform 2", "refseq_ac": [ { "id": "NP_001157111", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157111", "type": "external" } ], "gene_names_uniprotkb": "Cfap70; Ttc18", "gene_names_refseq": "Cfap70; Ttc18", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 70; TPR repeat protein 18; Tetratricopeptide repeat protein 18", "protein_names_refseq": "TPR repeat protein 18; cilia- and flagella-associated protein 70 isoform 2; tetratricopeptide repeat domain 18; tetratricopeptide repeat protein 18", "tax_id": 10090, "disease": "oligoasthenoteratozoospermia (Disease Ontology:DOID:0070311); spermatogenic failure 41 (Disease Ontology:DOID:0111912)", "pathway": " (mmu:76670)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17971504;30158508;37352829;37458246;39704931;39853433", "class_list": "", "function": "Axoneme-binding protein that plays a role in the regulation of ciliary motility and cilium length (PubMed:30158508). Essential for the assembly of the sperm flagellum and the correct shaping of the sperm head, during spermiogenesis (PubMed:37458246, PubMed:37352829). Contributes in part to flagellar biogenesis by stabilizing QRICH2, promoting the cytoplasmic preassembly of CFAP61 and CFAP91, and regulating the manchette localization of axoneme-associated proteins such as IFT88, DNAI1 and CFAP61 (PubMed:37352829)., [UniProtKB, PubMed, PubMed, PubMed]; Ttc18 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7ZNG2;B7ZNG3;D3Z1K9;E9Q7X8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:1990716 axonemal central apparatus;GO:0005737 cytoplasm;GO:0031514 motile cilium;GO:0036126 sperm flagellum;GO:0002177 manchette", "go_biological_process": "GO:0098727 maintenance of cell number;GO:0030317 flagellated sperm motility;GO:0000902 cell morphogenesis;GO:0007286 spermatid development;GO:0007338 single fertilization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "D3YVL2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z5L4-1", "uniprot_id": [ { "id": "D3Z5L4_MOUSE", "url": "https://www.uniprot.org/uniprot/D3Z5L4", "type": "external" } ], "mass": 77408.0, "length": 667, "protein_name": "Zinc finger protein 1007", "gene_name": "Zfp1007", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC77200", "refseq_ac": [ { "id": "NP_001365517", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001365517", "type": "external" } ], "gene_names_uniprotkb": "Zfp1007; 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3.2.1.23", "protein_names_refseq": "beta-galactosidase-like protein precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:382064)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004565 beta-galactosidase activity", "go_cellular_component": "GO:0005773 vacuole", "go_biological_process": "GO:0019388 galactose catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F6Y113-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R0H9-1", "uniprot_id": [ { "id": "GGA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R0H9", "type": "external" } ], "mass": 69972.0, "length": 635, "protein_name": "ADP-ribosylation factor-binding protein GGA1", "gene_name": "Gga1", "organism": "Mouse", "refseq_name": "ADP-ribosylation factor-binding protein GGA1", "refseq_ac": [ { "id": "NP_666041", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666041", "type": "external" } ], "gene_names_uniprotkb": "Gga1", "gene_names_refseq": "4930406E12Rik; Gga1", "protein_names_uniprotkb": "ADP-ribosylation factor-binding protein GGA1; Gamma-adaptin-related protein 1; Golgi-localized, gamma ear-containing, ARF-binding protein 1", "protein_names_refseq": "ADP-ribosylation factor-binding protein GGA1; gamma-adaptin-related protein 1; golgi-localized, gamma ear-containing, ARF-binding protein 1", "tax_id": 10090, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); lysosomal storage disease (Disease Ontology:DOID:3211)", "pathway": " (mmu:106039)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "11950392;12376537;15466887;15774496;16407204;19864490;21750661;22522702;25405894;30440034;34428180;37551344;39002678", "class_list": "", "function": "GGA1 interacts with the endosomal Na+/H+ exchanger NHE6 governing localization to the endosome compartment., [RefSeq, PubMed]; GGA1 participates in spermatogenesis in mice under stress. Publication Status: Online-Only, [RefSeq, PubMed]; Glut4 insulin-responsive trafficking is mediated by GGA adaptors in mouse adipocytes, [RefSeq, PubMed]; Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes (PubMed:25405894). Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif. Mediates export of the GPCR receptor ADRA2B to the cell surface (By similarity). Required for targeting PKD1:PKD2 complex from the trans-Golgi network to the cilium membrane (PubMed:25405894). Regulates retrograde transport of proteins such as phosphorylated form of BACE1 from endosomes to the trans-Golgi network (By similarity)., [UniProtKB, UniProtKB, PubMed]; Serine phosphorylation of BACE is a physiologically relevant post-translational modification that regulates trafficking in the juxtanuclear compartment by interaction with GGA1, [RefSeq, PubMed]; Termination of Arf1 signals mediated through GGA require that Arf1.GTP dissociates from GGA prior to interaction with GAP and consequent hydrolysis of GTP, [RefSeq, PubMed]; The trafficking of adiponectin through its secretory pathway is dependent on GGA-coated vesicles, [RefSeq, PubMed]; These results suggested that GGA1 plays a significant role in the formation and maturation of myotubes by targeting the insulin receptor to the cell surface to establish functionally mature myofibers. Erratum:[PLoS One. 2018 Dec 13;13(12):e0209441. doi: 10.1371/journal.pone.0209441. 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{ "id": "A2AW64_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AW64", "type": "external" } ], "mass": 9167.0, "length": 81, "protein_name": "Zinc finger protein 972", "gene_name": "Zfp972", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC78703", "refseq_ac": [ { "id": "NP_898958", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_898958", "type": "external" } ], "gene_names_uniprotkb": "Zfp972; C330013J21Rik", "gene_names_refseq": "C330013J21Rik; Zfp972", "protein_names_uniprotkb": "Zinc finger protein 972", "protein_names_refseq": "uncharacterized protein LOC78703", "tax_id": 10090, "disease": "", "pathway": " (mmu:78703)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 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Gm15319", "gene_names_refseq": "Gm15319; Pote3a; Poteb; Potefam3a", "protein_names_uniprotkb": "POTE ankyrin domain family member 3A", "protein_names_refseq": "POTE ankyrin domain family member B; testis-specific gene with ankyrin repeats and PEST domain-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:100040599)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003950 NAD+ poly-ADP-ribosyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0070198 protein localization to chromosome, telomeric region;GO:0090263 positive regulation of canonical Wnt signaling pathway;GO:1904355 positive regulation of telomere capping", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9Q637-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q6D8-1", "uniprot_id": [ { "id": "CO6_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q6D8", "type": "external" } ], "mass": 104624.0, "length": 934, "protein_name": "Complement component C6", "gene_name": "C6", "organism": "Mouse", "refseq_name": "complement component C6 precursor", "refseq_ac": [ { "id": "NP_057913", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_057913", "type": "external" } ], "gene_names_uniprotkb": "C6", "gene_names_refseq": "C6", "protein_names_uniprotkb": "Complement component C6", "protein_names_refseq": "complement component C6 precursor; 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The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways. The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Together with component C5b, involved in MAC complex assembly: complement C5b and C6 associate with the outer leaflet of target cell membrane, reducing the energy for membrane bending., [UniProtKB, UniProtKB]; Requirement of Complement C6 for Intact Innate Immune Responses in Mice., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 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"synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "E9Q6D8-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q777-1", "uniprot_id": [ { "id": "E9Q777_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q777", "type": "external" } ], "mass": 208761.0, "length": 1894, "protein_name": "A kinase anchor protein 11", "gene_name": "Akap11", "organism": "Mouse", "refseq_name": "A-kinase anchor protein 11 isoform 1", "refseq_ac": [ { "id": "NP_001157975", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157975", "type": "external" } ], "gene_names_uniprotkb": "Akap11", "gene_names_refseq": "6330501D17Rik; AKAP220; Akap11; Gm80; PRKA11; mKIAA0629", "protein_names_uniprotkb": "A kinase anchor protein 11", "protein_names_refseq": "A kinase (PRKA) anchor protein 11; A-kinase anchor protein 11 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:219181)", 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regulation of establishment of endothelial barrier;GO:0036010 protein localization to endosome;GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "E9Q777-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q3M9-1", "uniprot_id": [ { "id": "E9Q3M9_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q3M9", "type": "external" } ], "mass": 125910.0, "length": 1175, "protein_name": "Capping protein inhibiting regulator of actin like", "gene_name": "Cracdl", "organism": "Mouse", "refseq_name": "CRACD-like protein isoform 2", "refseq_ac": [ { "id": "NP_082372", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082372", "type": "external" } ], "gene_names_uniprotkb": "Cracdl; 2010300C02Rik", "gene_names_refseq": "2010300C02Rik; Cracdl", "protein_names_uniprotkb": "Capping protein 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"refseq_ac": [ { "id": "NP_001157093", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157093", "type": "external" } ], "gene_names_uniprotkb": "Apol6", "gene_names_refseq": "2310076O14Rik; Apol6", "protein_names_uniprotkb": "Apolipoprotein L 6", "protein_names_refseq": "apolipoprotein L6 isoform 2", "tax_id": 10090, "disease": "kidney disease (Disease Ontology:DOID:557)", "pathway": " (mmu:71939)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;30423386;38167864", "class_list": "", "function": "ApoL6 associates with lipid droplets and disrupts Perilipin1-HSL interaction to inhibit lipolysis. 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"https://www.uniprot.org/uniprot/A2A974", "type": "external" } ], "mass": 58309.0, "length": 508, "protein_name": "Cytochrome P450 4A12B", "gene_name": "Cyp4a12b", "organism": "Mouse", "refseq_name": "cytochrome P450 4A12B precursor", "refseq_ac": [ { "id": "NP_758510", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_758510", "type": "external" } ], "gene_names_uniprotkb": "Cyp4a12b", "gene_names_refseq": "Cyp4a12b; Cyp4a12", "protein_names_uniprotkb": "Cytochrome P450 4A12B; 1.14.14.1", "protein_names_refseq": "cytochrome P450 4A12B precursor; cytochrome P450 4A12B; cytochrome P450, family 4, subfamily a family; cytochrome P450, family 4, subfamily a, polypeptide 12", "tax_id": 10090, "disease": "autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); hypertension (Disease Ontology:DOID:10763)", "pathway": " (mmu:13118); (R-MMU-211935); (R-MMU-211958); (R-MMU-211979); (R-MMU-2142691); (R-MMU-2142816)", "pathway_count": 6, "publication_count": 4, "publication_id_list": "15066132;17112342;34428180;35820727", "class_list": "", "function": "'...Cyp4a12...is expressed in mouse lung... may be upregulated by...clofibrate and... cytokine IL-1Beta...IL-1Beta has been...associated with asthma...data raise the question...whether CYP4A expression could be altered in asthmatic conditions' p. 184-5, [RefSeq, PubMed]; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids and their oxygenated derivatives (oxylipins) (PubMed:17112342). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:17112342). Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of saturated and unsaturated fatty acids (PubMed:17112342). May act as a major omega-hydroxylase for dodecanoic (lauric) acid in kidney (PubMed:17112342). Participates in omega-hydroxylation of (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) to 20-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure (PubMed:17112342). Acts as an omega-hydroxylase and epoxidase toward (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoc acid (EPA). Catalyzes the epoxidation of the last double bond of EPA with no preferred stereoselectivity, producing both (R,S) and (S,R) stereoisomers (PubMed:17112342). Can also catalyze the omega-1 and omega-2 oxidation of fatty acids with lower efficiency (PubMed:17112342)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" }, { "id": "1.14.14.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.-", "type": "external" }, { "id": "1.14.14.80", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.80", "type": "external" }, { "id": "4.2.1.152", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.152", "type": "external" }, { "id": "1.14.13.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.n7", "type": "external" }, { "id": "1.14.14.79", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.79", "type": "external" }, { "id": "5.3.99.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.5", "type": "external" }, { "id": "1.14.14.94", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.94", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0008392 arachidonate epoxygenase activity;GO:0004497 monooxygenase activity;GO:0050051 leukotriene-B4 20-monooxygenase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0097267 omega-hydroxylase P450 pathway;GO:0046456 icosanoid biosynthetic process;GO:0006631 fatty acid metabolic process;GO:0001822 kidney development;GO:0043651 linoleic acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A2A974-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z6L3-1", "uniprot_id": [ { "id": "D3Z6L3_MOUSE", "url": "https://www.uniprot.org/uniprot/D3Z6L3", "type": "external" } ], "mass": 97600.0, "length": 852, "protein_name": "Vomeronasal 2, receptor 49", "gene_name": "Vmn2r49", "organism": "Mouse", "refseq_name": "vomeronasal 2, receptor 49", "refseq_ac": [ { "id": "NP_001098626", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098626", "type": "external" } ], "gene_names_uniprotkb": "Vmn2r49", "gene_names_refseq": "Vmn2r49", "protein_names_uniprotkb": "Vomeronasal 2, receptor 49", "protein_names_refseq": "vomeronasal 2, receptor 49; vomeronasal receptor Vmn2r49", "tax_id": 10090, "disease": "", "pathway": " (mmu:625605)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3Z6L3-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PYS0-1", "uniprot_id": [ { "id": "E9PYS0_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PYS0", "type": "external" } ], "mass": 97535.0, "length": 855, "protein_name": "Vomeronasal 2, receptor 108", "gene_name": "Vmn2r108", "organism": "Mouse", "refseq_name": "vomeronasal receptor Vmn2r108", "refseq_ac": [ { "id": "NP_001098040", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098040", "type": "external" } ], "gene_names_uniprotkb": "Vmn2r108; Vmn2r109", "gene_names_refseq": "EG627805; Vmn2r108", "protein_names_uniprotkb": "Vomeronasal 2, receptor 108", "protein_names_refseq": "vomeronasal receptor Vmn2r108", "tax_id": 10090, "disease": "", "pathway": " (mmu:627805)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9Q6V2", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E9PYS0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q4E0-1", "uniprot_id": [ { "id": "E9Q4E0_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q4E0", "type": "external" } ], "mass": 31501.0, "length": 267, "protein_name": "RIKEN cDNA 5031410I06 gene", "gene_name": "5031410I06Rik", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC381622", "refseq_ac": [ { "id": "NP_997540", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997540", "type": "external" } ], "gene_names_uniprotkb": "5031410I06Rik", "gene_names_refseq": "5031410I06Rik", "protein_names_uniprotkb": "RIKEN cDNA 5031410I06 gene", "protein_names_refseq": "uncharacterized protein LOC381622", "tax_id": 10090, "disease": "", "pathway": " (mmu:381622)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9Q4E0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q6K3-1", "uniprot_id": [ { "id": "E9Q6K3_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q6K3", "type": "external" } ], "mass": 89560.0, "length": 756, "protein_name": "Progesterone immunomodulatory binding factor 1", "gene_name": "Pibf1", "organism": "Mouse", "refseq_name": "progesterone-induced-blocking factor 1", "refseq_ac": [ { "id": "NP_083596", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083596", "type": "external" } ], "gene_names_uniprotkb": "Pibf1", "gene_names_refseq": "Pibf1", "protein_names_uniprotkb": "Progesterone immunomodulatory binding factor 1", "protein_names_refseq": "progesterone-induced blocking factor 1; progesterone-induced-blocking factor 1", "tax_id": 10090, "disease": "Joubert syndrome 33 (Disease Ontology:DOID:0080279)", "pathway": " (mmu:52023)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;29549351;38374152", "class_list": "", "function": "Data suggest, that PIBF transported by the extracellular vesicles( EVs) from the embryo to maternal lymphocytes might induce increased IL-10 production by the latter, this way contributing to the Th2 dominant immune responses described during pregnancy. Publication Status: Online-Only, [RefSeq, PubMed]; PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005136 interleukin-4 receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005813 centrosome;GO:0005815 microtubule organizing center;GO:0034451 centriolar satellite", "go_biological_process": "GO:0031393 negative regulation of prostaglandin biosynthetic process;GO:0090307 mitotic spindle assembly;GO:0060271 cilium assembly;GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein;GO:0007080 mitotic metaphase chromosome alignment", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "E9Q6K3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q745-1", "uniprot_id": [ { "id": "E9Q745_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q745", "type": "external" } ], "mass": 81550.0, "length": 711, "protein_name": "Amine oxidase", "gene_name": "Aoc1l2", "organism": "Mouse", "refseq_name": "diamine oxidase-like protein 1 precursor", "refseq_ac": [ { "id": "NP_001074742", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074742", "type": "external" } ], "gene_names_uniprotkb": "Aoc1l2; 1600015I10Rik; Doxl1", "gene_names_refseq": "1600015I10Rik; Aoc1l2; Doxl1", "protein_names_uniprotkb": "Amine oxidase; 1.4.3.-", "protein_names_refseq": "diamine oxidase-like protein 1 precursor; diamine oxidase-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:69761)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0042803 protein homodimerization activity;GO:0005509 calcium ion binding;GO:0005507 copper ion binding;GO:0008131 primary methylamine oxidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0070062 extracellular exosome", "go_biological_process": "GO:0009445 putrescine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9Q745-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F8VPU6-1", "uniprot_id": [ { "id": "USP9Y_MOUSE", "url": "https://www.uniprot.org/uniprot/F8VPU6", "type": "external" } ], "mass": 292267.0, "length": 2556, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 9Y", "gene_name": "Usp9y", "organism": "Mouse", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 9Y", "refseq_ac": [ { "id": "NP_683745", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_683745", "type": "external" } ], "gene_names_uniprotkb": "Usp9y", "gene_names_refseq": "Dffry; 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May stabilize target proteins that are important for male germ cell development., [UniProtKB, UniProtKB]; Selection is acting to maintain the amino acid sequence of both the X and the Y-linked genes., [RefSeq, PubMed]; Variations in Usp9y and the number of CAG repeats in Sry are significantly associated with testes weight., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9409, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q91XW2", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0016477 cell migration;GO:0016579 protein deubiquitination;GO:0031647 regulation of protein stability;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "F8VPU6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "J3QNH8-1", "uniprot_id": [ { "id": "J3QNH8_MOUSE", "url": "https://www.uniprot.org/uniprot/J3QNH8", "type": "external" } ], "mass": 28502.0, "length": 270, "protein_name": "Predicted gene 7694", "gene_name": "Gm7694", "organism": "Mouse", "refseq_name": "uncharacterized protein C1orf226 homolog", "refseq_ac": [ { "id": "NP_001185884", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185884", "type": "external" } ], "gene_names_uniprotkb": "Gm7694", "gene_names_refseq": "EG665574; 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Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner (By similarity). May promote axon outgrowth and motor fiber repair via DSP-mediated recruitment to outgrowth tips (PubMed:25496840)., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 2, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 12, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 12, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 12, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 49, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 15, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "O08704;Q8CCH1", "ec_number_list": [], "go_molecular_function": "GO:1990254 keratin filament binding;GO:0060090 molecular adaptor activity;GO:0003723 RNA binding;GO:0005200 structural constituent of cytoskeleton;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005777 peroxisome;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0060252 positive regulation of glial cell proliferation;GO:0010628 positive regulation of gene expression;GO:0043488 regulation of mRNA stability;GO:0010977 negative regulation of neuron projection development", "synthesized_glycan_count": 0, "hit_score": 8.6, "record_id": "P20152-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K019-1", "uniprot_id": [ { "id": "BCLF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K019", "type": "external" } ], "mass": 106002.0, "length": 919, "protein_name": "Bcl-2-associated transcription factor 1", "gene_name": "Bclaf1", "organism": "Mouse", "refseq_name": "bcl-2-associated transcription factor 1 isoform 1", "refseq_ac": [ { "id": "NP_001020563", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020563", "type": "external" } ], "gene_names_uniprotkb": "Bclaf1; Btf; Kiaa0164", "gene_names_refseq": "2610102K23Rik; 2700025J07Rik; 2810454G14Rik; 5730534O06Rik; Bclaf1; Btf; mKIAA0164", "protein_names_uniprotkb": "Bcl-2-associated transcription factor 1; Btf", "protein_names_refseq": "bcl-2-associated transcription factor 1 isoform 1; bcl-2-associated transcription factor 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:72567)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "16452087;17242355;18630941;19131326;19144319;21183079;21750661;23806337;24463520;25428506;31599954;31644907;33483496;34693625;34887587;35321563;35820727;39627609", "class_list": "", "function": "Bclaf1 regulates c-FLIP expression and protects cells from TNF-induced apoptosis and tissue injury., [RefSeq, PubMed]; Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA (By similarity)., [UniProtKB]; Plaque Evaluation by Ultrasound and Transcriptomics Reveals BCLAF1 as a Regulator of Smooth Muscle Cell Lipid Transdifferentiation in Atherosclerosis., [RefSeq, PubMed]; RAG-Mediated DNA Breaks Attenuate PU.1 Activity in Early B Cells through Activation of a SPIC-BCLAF1 Complex., [RefSeq, PubMed]; The long noncoding RNA lncCIRBIL disrupts the nuclear translocation of Bclaf1 alleviating cardiac ischemia-reperfusion injury. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 44, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BNZ0;Q8C2E9;Q9CSW5", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0016592 mediator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0043065 positive regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:1990830 cellular response to leukemia inhibitory factor", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q8K019-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2VPD4-1", "uniprot_id": [ { "id": "BMAL2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q2VPD4", "type": "external" } ], "mass": 64399.0, "length": 579, "protein_name": "Basic helix-loop-helix ARNT-like protein 2", "gene_name": "Bmal2", "organism": "Mouse", "refseq_name": "basic helix-loop-helix ARNT-like protein 2 isoform 2", "refseq_ac": [ { "id": "NP_001276608", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276608", "type": "external" } ], "gene_names_uniprotkb": "Bmal2; Arntl2", "gene_names_refseq": "4632430A05Rik; Arntl2; Bmal2; CLIF; MOP9; bHLHe6", "protein_names_uniprotkb": "Basic helix-loop-helix ARNT-like protein 2; Aryl hydrocarbon receptor nuclear translocator-like protein 2; Brain and muscle ARNT-like 2", "protein_names_refseq": "aryl hydrocarbon receptor nuclear translocator-like 2; aryl hydrocarbon receptor nuclear translocator-like protein 2; basic helix-loop-helix ARNT-like protein 2 isoform 2; basic helix-loop-helix ARNT-like protein 2; brain and muscle ARNT-like 2; brain-muscle-ARNT-like protein 2", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); hypertension (Disease Ontology:DOID:10763); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:272322)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11207387;16685415;16893914;19605937;20153195;21750661;27671790;31219806;35820727;38531632;38938563", "class_list": "", "function": "Arntl2 exhibited a six-fold upregulation in spleens of the NOD.C3H 6.VIII congenic strain compared with the NOD control strain, strain-specific splice variants and a large number of polymorphisms in both coding and non-coding regions., [RefSeq, PubMed]; BMAL2 promotes eCIRP-induced macrophage endotoxin tolerance. Publication Status: Online-Only, [RefSeq, PubMed]; Deletion of the Clock Gene Bmal2 Leads to Alterations in Hypothalamic Clocks, Circadian Regulation of Feeding, and Energy Balance. Publication Status: Online-Only, [RefSeq, PubMed]; Our results identify Arntl2 as a gene controlling thymocyte apoptosis and proliferation along with Th17 development through the IL-21 pathway., [RefSeq, PubMed]; These findings demonstrate that (57)Arg in the basic region of DEC2 is essential for its activity in suppressing CLOCK/BMAL2-mediated transactivation., [RefSeq, PubMed]; This gene encodes a basic helix-loop-helix transcription factor belonging to the PAS (Per, Arnt, Sim) superfamily. The PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations in light and temperature. This protein forms a transcriptionally active heterodimer with the circadian Clock protein, the structurally related Mop4, and hypoxia-inducible factors, such as Hif1alpha. Consistent with its role as a biologically relevant partner of circadian and hypoxia factors, this protein is coexpressed in regions of the brain such as the thalamus, hypothalamus, and amygdala. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2014]., [RefSeq]; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. The CLOCK-BMAL2 heterodimer activates the transcription of SERPINE1/PAI1 and BHLHE40/DEC1., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q32MV7;Q91XJ5;Q91XJ6", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0070888 E-box binding", "go_cellular_component": "GO:1990513 CLOCK-BMAL transcription complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0007623 circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q2VPD4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BYR5-1", "uniprot_id": [ { "id": "CAPS2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BYR5", "type": "external" } ], "mass": 147841.0, "length": 1297, "protein_name": "Calcium-dependent secretion activator 2", "gene_name": "Cadps2", "organism": "Mouse", "refseq_name": "calcium-dependent secretion activator 2 isoform 2", "refseq_ac": [ { "id": "NP_001239034", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239034", "type": "external" } ], "gene_names_uniprotkb": "Cadps2; Caps2", "gene_names_refseq": "A230044C21Rik; Cadps2; Caps-2; Caps2; Cpd2", "protein_names_uniprotkb": "Calcium-dependent secretion activator 2; CAPS-2; Calcium-dependent activator protein for secretion 2", "protein_names_refseq": "calcium-dependent secretion activator 2 isoform 2; calcium-dependent secretion activator 2; cerebellum postnatal development associated protein 2", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (mmu:320405)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;12659812;14530279;14715936;15820695;21183079;21750661;33580180;34418053", "class_list": "", "function": "Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles., [UniProtKB]; Down-regulation of habenular calcium-dependent secretion activator 2 induces despair-like behavior. Publication Status: Online-Only, [RefSeq, PubMed]; Identification, cloning, and comparative characterization of a second mammalian CAPS isoform, CAPS2; concluded that at the functional level, CAPS2 is largely redundant with CAPS1, [RefSeq, PubMed]; Results suggest that CAPS2 mediates the depolarization-dependent release of NT-3 and BDNF from granule cells, leading to regulation in cell differentiation and survival during cerebellar development, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "O08903;Q66JM7;Q6PCL7;Q76I88;Q7TMM6;Q80ZV8;Q8BL25;Q8BY04;Q8K3K6", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005929 cilium;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0015031 protein transport;GO:0009267 cellular response to starvation;GO:0006887 exocytosis;GO:0016082 synaptic vesicle priming;GO:0045921 positive regulation of exocytosis", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q8BYR5-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z6Q9-1", "uniprot_id": [ { "id": "BIN2_MOUSE", "url": "https://www.uniprot.org/uniprot/D3Z6Q9", "type": "external" } ], "mass": 52554.0, "length": 489, "protein_name": "Bridging integrator 2", "gene_name": "Bin2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Bin2", "gene_names_refseq": "", "protein_names_uniprotkb": "Bridging integrator 2", "protein_names_refseq": "", "tax_id": 10090, "disease": "centronuclear myopathy 2 (Disease Ontology:DOID:0111220)", "pathway": " (mmu:668218); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "17242355;21183079;21750661;23285027;26495903;34428180", "class_list": "", "function": "Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Inhibits phagocytosis (By similarity). Plays a role in podosome formation., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding", "go_cellular_component": "GO:0001891 phagocytic cup;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0002102 podosome;GO:0042995 cell projection", "go_biological_process": "GO:0006911 phagocytosis, engulfment;GO:0060326 cell chemotaxis;GO:0071800 podosome assembly;GO:0097320 plasma membrane tubulation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "D3Z6Q9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88738-1", "uniprot_id": [ { "id": "BIRC6_MOUSE", "url": "https://www.uniprot.org/uniprot/O88738", "type": "external" } ], "mass": 532170.0, "length": 4882, "protein_name": "Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6", "gene_name": "Birc6", "organism": "Mouse", "refseq_name": "dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform 1", "refseq_ac": [ { "id": "NP_031592", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031592", "type": "external" } ], "gene_names_uniprotkb": "Birc6; Kiaa1289", "gene_names_refseq": "A430032G04Rik; A430040A19Rik; Birc6; Bruce; D630005A10Rik; mKIAA1289", "protein_names_uniprotkb": "Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6; 2.3.2.24; APOLLON; BIR repeat-containing ubiquitin-conjugating enzyme; BRUCE; Baculoviral IAP repeat-containing protein 6; Ubiquitin-conjugating BIR domain enzyme apollon", "protein_names_refseq": "BIR repeat-containing ubiquitin-conjugating enzyme; RING-type E3 ubiquitin transferase BIRC6; accccbaculoviral IAP repeat-containing 6; apollon; baculoviral IAP repeat-containing protein 6; baculovirus inhibitor of apoptosis repeat containing ubiquitin-conjugating enzyme; dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform 1; dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6; ubiquitin-conjugating BIR domain enzyme apollon", "tax_id": 10090, "disease": "", "pathway": " (mmu:12211)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "10.1101/2023.09.13.557529;15300255;15485903;16479539;17242355;21183079;21750661;21952136;25428506;25605945;26495903;28011936;30084848;30779550;31219806;32152506;33725478;34203471;34354038;34428180;35820727;36210013;37507081;37828378;9628897", "class_list": "", "function": "Anti-apoptotic protein known as inhibitor of apoptosis (IAP) which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase (PubMed:9628897, PubMed:15485903). Unlike most IAPs, does not contain a RING domain and it is not a RING-type E3 ligase (By similarity). Instead acts as a dual E2/E3 enzyme that combines ubiquitin conjugating (E2) and ubiquitin ligase (E3) activities in a single polypeptide (PubMed:15485903, PubMed:15300255). Ubiquitination is mediated by a non-canonical E1 ubiquitin activating enzyme UBA6 (By similarity). Ubiquitinates CASP3, CASP7 and CASP9 and inhibits their caspase activity; also ubiquitinates their procaspases but to a weaker extent (By similarity). Ubiquitinates pro-apoptotic factors DIABLO/SMAC and HTRA2 (PubMed:15300255). DIABLO/SMAC antagonizes the caspase inhibition activity of BIRC6 by competing for the same binding sites as the caspases (By similarity). Ubiquitinates the autophagy protein MAP1LC3B; this activity is also inhibited by DIABLO/SMAC (By similarity). Important regulator for the final stages of cytokinesis (By similarity). Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification. Required for normal placenta development (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; BRUCE silencing leads to axonal dystrophy by repressing autophagosome-lysosome fusion in Alzheimer's disease. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "E9PYU6;Q69ZM5;Q8BNX0;Q8BR72;Q8BRV7;Q8C737", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004842 ubiquitin-protein transferase activity;GO:0004869 cysteine-type endopeptidase inhibitor activity;GO:0061631 ubiquitin conjugating enzyme activity;GO:0016740 transferase activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005813 centrosome", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0042127 regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0051301 cell division;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "O88738-1", "record_type": "protein", "filter_code": "0000000.1000101.000100.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UQU0-1", "uniprot_id": [ { "id": "BRD9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UQU0", "type": "external" } ], "mass": 66840.0, "length": 596, "protein_name": "Bromodomain-containing protein 9", "gene_name": "Brd9", "organism": "Mouse", "refseq_name": "bromodomain-containing protein 9 isoform 1", "refseq_ac": [ { "id": "NP_001019679", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019679", "type": "external" } ], "gene_names_uniprotkb": "Brd9", "gene_names_refseq": "Brd9", "protein_names_uniprotkb": "Bromodomain-containing protein 9", "protein_names_refseq": "bromodomain-containing protein 9 isoform 1; bromodomain-containing protein 9", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:105246); (R-MMU-9933947)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;29374058;31219806;34428180", "class_list": "", "function": "Plays a role in chromatin remodeling and regulation of transcription. Acts as a chromatin reader that recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated. Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Also orchestrates the RAD51-RAD54 complex formation and thereby plays a role in homologous recombination (HR)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9820, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q0P669;Q5FWH1;Q811F7", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0140566 histone reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016514 SWI/SNF complex;GO:0000785 chromatin;GO:0035861 site of double-strand break", "go_biological_process": "GO:1902459 positive regulation of stem cell population maintenance;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q3UQU0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70273-1", "uniprot_id": [ { "id": "EHF_MOUSE", "url": "https://www.uniprot.org/uniprot/O70273", "type": "external" } ], "mass": 34903.0, "length": 300, "protein_name": "ETS homologous factor", "gene_name": "Ehf", "organism": "Mouse", "refseq_name": "ETS homologous factor", "refseq_ac": [ { "id": "NP_031940", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031940", "type": "external" } ], "gene_names_uniprotkb": "Ehf", "gene_names_refseq": "9030625L19Rik; Ehf", "protein_names_uniprotkb": "ETS homologous factor; ETS domain-containing transcription factor", "protein_names_refseq": "ETS domain-containing transcription factor; ETS homologous factor", "tax_id": 10090, "disease": "abdominal aortic aneurysm (Disease Ontology:DOID:7693)", "pathway": " (mmu:13661)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "16704374;18250455;21750661;30084848;36348499;38513137;38781975;9600089", "class_list": "", "function": "Cpeb4-mediated Dclk2 promotes neuronal pyroptosis induced by chronic cerebral ischemia through phosphorylation of Ehf., [RefSeq, PubMed]; Ehf controls mammary alveolar lineage differentiation and is a putative suppressor of breast tumorigenesis., [RefSeq, PubMed]; Genetic Study of Elf5 and Ehf in the Mouse Salivary Gland., [RefSeq, PubMed]; Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation. May act as a repressor for a specific subset of ETS/AP-1-responsive genes, and as a modulator of the nuclear response to mitogen-activated protein kinase signaling cascades. Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through Ets-binding sequences on the TNFRSF10B/DR5 promoter (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q922E8;Q922T6;Q99K12", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0030855 epithelial cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O70273-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q69Z98-1", "uniprot_id": [ { "id": "BRSK2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q69Z98", "type": "external" } ], "mass": 81733.0, "length": 735, "protein_name": "Serine/threonine-protein kinase BRSK2", "gene_name": "Brsk2", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase BRSK2 isoform beta", "refseq_ac": [ { "id": "NP_001009929", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009929", "type": "external" } ], "gene_names_uniprotkb": "Brsk2; Kiaa4256; Sada", "gene_names_refseq": "4833424K13Rik; Brsk2; SAD-A; SADA", "protein_names_uniprotkb": "Serine/threonine-protein kinase BRSK2; 2.7.11.1; 2.7.11.26; BR serine/threonine-protein kinase 2; Brain-specific serine/threonine-protein kinase 2; Serine/threonine-protein kinase SAD-A", "protein_names_refseq": "BR serine/threonine-protein kinase 2; brain-specific serine/threonine-protein kinase 2; serine/threonine-protein kinase BRSK2 isoform beta; serine/threonine-protein kinase BRSK2; serine/threonine-protein kinase SAD-A", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (mmu:75770)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "15705853;17482548;20026642;21183079;21750661;22669945;22798068;29873699;30307479;30573363;37188647", "class_list": "", "function": "BRSK2 in pancreatic beta cells promotes hyperinsulinemia-coupled insulin resistance and its genetic variants are associated with human type 2 diabetes., [RefSeq, PubMed]; Glucose and incretin stimulate insulin secretion through the phosphorylation of GDIalpha at Ser174 by SAD-A, which leads to the activation of Rho GTPases, culminating in insulin exocytosis., [RefSeq, PubMed]; Isozyme-Specific Role of SAD-A in Neuronal Migration During Development of Cerebral Cortex., [RefSeq, PubMed]; Once activated, LKB1 phosphorylates and thereby activates SAD-A and SAD-B kinases, which are also required for neuronal polarization in the cerebral cortex., [RefSeq, PubMed]; Results show that SAD-A and SAD-B, mammalian orthologs of a kinase needed for presynaptic differentiation in Caenorhabditis elegans, are required for neuronal polarization., [RefSeq, PubMed]; SAD-A is activated by the incretin hormone GLP-1 in pancreatic beta-cell. SAD-A promotes the phosphorylation of Bad S155., [RefSeq, PubMed]; Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-504' and 'Ser-554'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-175 can inhibit insulin secretion (PubMed:22798068), BRSK2 phosphorylated at Thr-261 can promote insulin secretion (PubMed:22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmic reticulum (ER) stress., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q699J3;Q699J4;Q6DMN7;Q6PHM0", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0051117 ATPase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005813 centrosome;GO:0048471 perinuclear region of cytoplasm;GO:0150034 distal axon", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0006468 protein phosphorylation;GO:0007409 axonogenesis;GO:0051301 cell division;GO:0000086 G2/M transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q69Z98-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P5E8-1", "uniprot_id": [ { "id": "DGKQ_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P5E8", "type": "external" } ], "mass": 102254.0, "length": 934, "protein_name": "Diacylglycerol kinase theta", "gene_name": "Dgkq", "organism": "Mouse", "refseq_name": "diacylglycerol kinase theta isoform 1", "refseq_ac": [ { "id": "NP_950176", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_950176", "type": "external" } ], "gene_names_uniprotkb": "Dgkq", "gene_names_refseq": "110kDa; DAGK7; DAGK; Dagk4; Dgkd; Dgkq", "protein_names_uniprotkb": "Diacylglycerol kinase theta; 2.7.1.107; 2.7.1.93; DAG kinase theta; DGK-theta; Diglyceride kinase theta", "protein_names_refseq": "DAG kinase theta; DGK-theta; Dgk theta; diacylglycerol kinase theta isoform 1; diacylglycerol kinase, delta (110 kDa); diglyceride kinase theta", "tax_id": 10090, "disease": "", "pathway": " (mmu:110524); (R-MMU-114508)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;26748701;31836314", "class_list": "", "function": "Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:26748701). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:26748701). Within the adrenocorticotropic hormone signaling pathway, produces phosphatidic acid which in turn activates NR5A1 and subsequent steroidogenic gene transcription (By similarity). Also functions downstream of the nerve growth factor signaling pathway being specifically activated in the nucleus by the growth factor (By similarity). Through its diacylglycerol activity also regulates synaptic vesicle endocytosis (PubMed:26748701)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Roles of DGKs in neurons: Postsynaptic functions? Review article Erratum:[Adv Biol Regul. 2021 Dec;82:100846. doi: 10.1016/j.jbior.2021.100846. PMID: 34862141], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9781, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UYE8", "ec_number_list": [ { "id": "2.7.1.107", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.107", "type": "external" }, { "id": "2.7.1.93", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.93", "type": "external" }, { "id": "2.7.1.94", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.94", "type": "external" }, { "id": "2.7.1.138", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.138", "type": "external" } ], "go_molecular_function": "GO:0004143 ATP-dependent diacylglycerol kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0019900 kinase binding;GO:0030971 receptor tyrosine kinase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005768 endosome", "go_biological_process": "GO:0046339 diacylglycerol metabolic process;GO:0046834 lipid phosphorylation;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006654 phosphatidic acid biosynthetic process;GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6P5E8-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TPS5-1", "uniprot_id": [ { "id": "C2CD5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TPS5", "type": "external" } ], "mass": 111664.0, "length": 1016, "protein_name": "C2 domain-containing protein 5", "gene_name": "C2cd5", "organism": "Mouse", "refseq_name": "C2 domain-containing protein 5 isoform 3", "refseq_ac": [ { "id": "NP_001103158", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103158", "type": "external" } ], "gene_names_uniprotkb": "C2cd5; 5730419I09Rik; Cdp138; Kiaa0528", "gene_names_refseq": "5730419I09Rik; C030008B15Rik; C2cd5; CDP138", "protein_names_uniprotkb": "C2 domain-containing protein 5; 138 kDa C2 domain-containing phosphoprotein", "protein_names_refseq": "138 kDa C2 domain-containing phosphoprotein; C2 domain-containing protein 5 isoform 3; C2 domain-containing protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:74741)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;20173027;21183079;21750661;21907143;21952136;22872234;25428506;30084848;30779550;31666192;34203471;34428180;34678516;35822049;36210013;40885482", "class_list": "", "function": "Hypothalamic C2CD5 is involved in MC4R endocytosis and regulate bodyweight homeostasis. This suggests that C2CD5 represents a new protein regulated by metabolic cues and involved in metabolic receptor endocytosis. C2CD5 represents a new target and pathway that could be targeted in Obesity., [RefSeq, PubMed]; Required for insulin-stimulated glucose transport and glucose transporter SLC2A4/GLUT4 translocation from intracellular glucose storage vesicle (GSV) to the plasma membrane (PM) in adipocytes. Binds phospholipid membranes in a calcium-dependent manner and is necessary for the optimal membrane fusion between SLC2A4/GLUT4 GSV and the PM., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q3TQY6;Q6A052;Q80VA1;Q8C0U3;Q8CID5;Q9CS85", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005544 calcium-dependent phospholipid binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0030659 cytoplasmic vesicle membrane;GO:0032587 ruffle membrane", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0008286 insulin receptor signaling pathway;GO:0031340 positive regulation of vesicle fusion;GO:0065002 intracellular protein transmembrane transport;GO:0090314 positive regulation of protein targeting to membrane", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q7TPS5-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q921N6-1", "uniprot_id": [ { "id": "DDX27_MOUSE", "url": "https://www.uniprot.org/uniprot/Q921N6", "type": "external" } ], "mass": 85939.0, "length": 760, "protein_name": "Probable ATP-dependent RNA helicase DDX27", "gene_name": "Ddx27", "organism": "Mouse", "refseq_name": "probable ATP-dependent RNA helicase DDX27", "refseq_ac": [ { "id": "NP_694705", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694705", "type": "external" } ], "gene_names_uniprotkb": "Ddx27", "gene_names_refseq": "Ddx27", "protein_names_uniprotkb": "Probable ATP-dependent RNA helicase DDX27; 3.6.4.13; DEAD box protein 27", "protein_names_refseq": "DEAD (Asp-Glu-Ala-Asp) box polypeptide 27; DEAD box protein 27; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 27; RNA-helicase like protein; probable ATP-dependent RNA helicase DDX27", "tax_id": 10090, "disease": "", "pathway": " (mmu:228889)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "17242355;21183079;21750661;25428506;25605945;30084848;30779550;34428180;34887587", "class_list": "", "function": "Probable ATP-dependent RNA helicase. Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3' end formation of ribosomal 47S rRNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UUG2;Q8R0W3;Q8R1E2", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003676 nucleic acid binding;GO:0003724 RNA helicase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005694 chromosome", "go_biological_process": "GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q921N6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88597-1", "uniprot_id": [ { "id": "BECN1_MOUSE", "url": "https://www.uniprot.org/uniprot/O88597", "type": "external" } ], "mass": 51589.0, "length": 448, "protein_name": "Beclin-1", "gene_name": "Becn1", "organism": "Mouse", "refseq_name": "beclin-1 isoform 1", "refseq_ac": [ { "id": "NP_062530", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062530", "type": "external" } ], "gene_names_uniprotkb": "Becn1", "gene_names_refseq": "Atg6; Becn1", "protein_names_uniprotkb": "Beclin-1; Coiled-coil myosin-like BCL2-interacting protein", "protein_names_refseq": "Bcl-2-interacting protein beclin; Beclin-1; beclin-1 isoform 1; coiled-coil, myosin-like BCL2-interacting protein", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); polycystic kidney disease (Disease Ontology:DOID:0080322); Parkinsonism (Disease Ontology:DOID:0080855); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); anterior ischemic optic neuropathy (Disease Ontology:DOID:12010); Machado-Joseph disease (Disease Ontology:DOID:1440); depressive disorder (Disease Ontology:DOID:1596); breast cancer (Disease Ontology:DOID:1612); glaucoma (Disease Ontology:DOID:1686); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); glioblastoma (Disease Ontology:DOID:3068); ischemia (Disease Ontology:DOID:326); brain infarction (Disease Ontology:DOID:3454); middle cerebral artery infarction (Disease Ontology:DOID:3525); esophagus adenocarcinoma (Disease Ontology:DOID:4914); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); liver cirrhosis (Disease Ontology:DOID:5082); ureteral obstruction (Disease Ontology:DOID:5199); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); paraplegia (Disease Ontology:DOID:607); viral encephalitis (Disease Ontology:DOID:646); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); peritonitis (Disease Ontology:DOID:8283); osteoarthritis (Disease Ontology:DOID:8398); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677); diabetic retinopathy (Disease Ontology:DOID:8947); degenerative disc disease (Disease Ontology:DOID:90); Barrett's esophagus (Disease Ontology:DOID:9206); type 2 diabetes mellitus (Disease Ontology:DOID:9352); diabetic neuropathy (Disease Ontology:DOID:9743)", "pathway": " (mmu:56208); (R-MMU-1169408); (R-MMU-1632852); (R-MMU-5689880)", "pathway_count": 4, "publication_count": 21, "publication_id_list": "10.1101/2023.09.13.557529;10604474;12372286;14638851;14657337;17589504;18248095;19270693;20819940;21059846;21364619;21750661;22493499;23332761;25275521;27994061;28445460;29604308;32296308;34428398;9765397", "class_list": "", "function": "Beclin 1 is a critical component of mammalian autophagy, which has a role in tumor suppression, [RefSeq, PubMed]; Beclin 1 is an autophagy gene that may contribute to the pathogenesis of cancers, [RefSeq, PubMed]; Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Plays a central role in autophagy (PubMed:10604474, PubMed:12372286, PubMed:19270693, PubMed:28445460). Acts as a core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (PubMed:19270693, PubMed:25275521). Involved in regulation of degradative endocytic trafficking and required for the abscission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms (PubMed:25275521). Involved in endocytosis including endosome formation in neuronal cells (PubMed:25275521). May play a role in antiviral host defense (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Plays a central role in autophagy., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9781, "biomarker_type": "", "glycan_count": 1, "disease_count": 39, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q99J03", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019901 protein kinase binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:0097352 autophagosome maturation;GO:1902902 negative regulation of autophagosome assembly;GO:0051707 response to other organism;GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process;GO:0000045 autophagosome assembly", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "O88597-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0A6YY25-1", "uniprot_id": [ { "id": "BTBDI_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A0A6YY25", "type": "external" } ], "mass": 79464.0, "length": 723, "protein_name": "BTB/POZ domain-containing protein 18", "gene_name": "Btbd18", "organism": "Mouse", "refseq_name": "BTB/POZ domain-containing protein 18", "refseq_ac": [ { "id": "NP_001138572", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138572", "type": "external" } ], "gene_names_uniprotkb": "Btbd18", "gene_names_refseq": "Btbd18-ps; Btbd18; Gm13718", "protein_names_uniprotkb": "BTB/POZ domain-containing protein 18", "protein_names_refseq": "BTB (POZ) domain containing 18, pseudogene; BTB/POZ domain-containing protein 18", "tax_id": 10090, "disease": "", "pathway": " (mmu:100270744)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21183079;25428506;28292424", "class_list": "", "function": "BTBD18 is a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA loci., [RefSeq, PubMed]; Specifically required during spermatogenesis to promote expression of piRNA precursors. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity. Acts by facilitating transcription elongation at piRNA loci during pachytene., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0007141 male meiosis I;GO:0032968 positive regulation of transcription elongation by RNA polymerase II;GO:0010526 transposable element silencing", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A0A6YY25-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U319-1", "uniprot_id": [ { "id": "BRE1B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U319", "type": "external" } ], "mass": 113967.0, "length": 1001, "protein_name": "E3 ubiquitin-protein ligase BRE1B", "gene_name": "Rnf40", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase BRE1B isoform 1", "refseq_ac": [ { "id": "NP_758485", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_758485", "type": "external" } ], "gene_names_uniprotkb": "Rnf40; Bre1b; Kiaa0661", "gene_names_refseq": "BRE1-B; Rnf40; mKIAA0661", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase BRE1B; 2.3.2.27; BRE1-B; RING finger protein 40; RING-type E3 ubiquitin transferase BRE1B", "protein_names_refseq": "E3 ubiquitin-protein ligase BRE1B isoform 1; E3 ubiquitin-protein ligase BRE1B; RING-type E3 ubiquitin transferase BRE1B", "tax_id": 10090, "disease": "nephrogenic diabetes insipidus (Disease Ontology:DOID:12387); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (mmu:233900); (R-MMU-8866654)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "20738173;21183079;21750661;22354749;23806337;28209164;30084848;30779550;34290256;37422774;39627609", "class_list": "", "function": "Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Massively parallel in vivo CRISPR screening identifies RNF20/40 as epigenetic regulators of cardiomyocyte maturation. Erratum:[Nat Commun. 2021 Aug 19;12(1):5105. doi: 10.1038/s41467-021-25373-1. PMID: 34413306] Publication Status: Online-Only, [RefSeq, PubMed]; Our results support a model in which the direct function of RNF40-mediated H2B monoubiquitination increases transcriptional elongation by promoting the spreading of H3K4me3 into the 5' transcribed region of a select subgroup of genes. Publication Status: Online-Only, [RefSeq, PubMed]; RNF20/RNF40 ameliorates streptozotocin-induced type 1 diabetes by activating vitamin D receptors in vivo. Publication Status: Online-Only, [RefSeq, PubMed]; The observed defects in the radiation response of Bre1a/b-deficient cells, [RefSeq, PubMed]; We show that Bre1 (human BRE1A/B (RNF20/40) and mouse Bre1a/b (Rnf20/40)) acts as an important suppressor of chromosomal instability, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZQ75;Q8BJA1;Q8BY03;Q8CHX4", "ec_number_list": [ { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0031625 ubiquitin protein ligase binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000151 ubiquitin ligase complex;GO:0032991 protein-containing complex;GO:0033503 HULC complex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0016567 protein ubiquitination;GO:0006325 chromatin organization;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q3U319-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UGY8-1", "uniprot_id": [ { "id": "BIG3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UGY8", "type": "external" } ], "mass": 240091.0, "length": 2170, "protein_name": "Brefeldin A-inhibited guanine nucleotide-exchange protein 3", "gene_name": "Arfgef3", "organism": "Mouse", "refseq_name": "brefeldin A-inhibited guanine nucleotide-exchange protein 3", "refseq_ac": [ { "id": "NP_001028430", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028430", "type": "external" } ], "gene_names_uniprotkb": "Arfgef3; Big3; D10Bwg1379e; Kiaa1244", "gene_names_refseq": "9630004D11; Arfgef3; B930094H20Rik; BIG3; D10Bwg1379e; mKIAA1244", "protein_names_uniprotkb": "Brefeldin A-inhibited guanine nucleotide-exchange protein 3; ARFGEF family member 3", "protein_names_refseq": "brefeldin A-inhibited guanine nucleotide-exchange protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:215821)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;15345747;18299400;21183079;21750661;22872234;24711543;25605945;25737957;30084848;33300544;34203471;34418053;35820727", "class_list": "", "function": "Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (PubMed:24711543). Also regulates glucagon granule production in pancreatic alpha cells (PubMed:25737957). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q80TH0", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0030658 transport vesicle membrane;GO:0016020 membrane", "go_biological_process": "GO:0016192 vesicle-mediated transport;GO:0032012 regulation of ARF protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q3UGY8-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AHJ4-1", "uniprot_id": [ { "id": "BRWD3_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AHJ4", "type": "external" } ], "mass": 202942.0, "length": 1799, "protein_name": "Bromodomain and WD repeat-containing protein 3", "gene_name": "Brwd3", "organism": "Mouse", "refseq_name": "bromodomain and WD repeat-containing protein 3", "refseq_ac": [ { "id": "NP_001074946", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074946", "type": "external" } ], "gene_names_uniprotkb": "Brwd3; Gm596", "gene_names_refseq": "Brodl; Brwd3; D030064D06Rik; Gm10452; Gm596", "protein_names_uniprotkb": "Bromodomain and WD repeat-containing protein 3", "protein_names_refseq": "bromo domain-containing protein disrupted in leukemia; bromodomain and WD repeat-containing protein 3", "tax_id": 10090, "disease": "non-syndromic X-linked intellectual disability 93 (Disease Ontology:DOID:0112045)", "pathway": " (mmu:382236)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21183079;21750661;30016717", "class_list": "", "function": "Required for regulation of cell morphology and cytoskeletal organization., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TQR7;Q3UTB6;Q640P3;Q8C7D5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0007010 cytoskeleton organization;GO:0008360 regulation of cell shape", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A2AHJ4-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CGU1-1", "uniprot_id": [ { "id": "CACO1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CGU1", "type": "external" } ], "mass": 77280.0, "length": 691, "protein_name": "Calcium-binding and coiled-coil domain-containing protein 1", "gene_name": "Calcoco1", "organism": "Mouse", "refseq_name": "calcium-binding and coiled-coil domain-containing protein 1", "refseq_ac": [ { "id": "NP_080468", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080468", "type": "external" } ], "gene_names_uniprotkb": "Calcoco1; CocoA; Kiaa1536", "gene_names_refseq": "1810009B06Rik; Calcoco1; Cocoa; Gcap11; mKIAA1536", "protein_names_uniprotkb": "Calcium-binding and coiled-coil domain-containing protein 1; Coiled-coil coactivator protein", "protein_names_refseq": "GRIP1-interacting protein; calcium-binding and coiled-coil domain-containing protein 1; coiled-coil coactivator protein; coiled-coil transcriptional coactivator; granule cell antiserum positive 11", "tax_id": 10090, "disease": "", "pathway": " (mmu:67488)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;14690606;15383530;15522220;16344550;16931570;17114649;21750661;24245781;31971854;32525583", "class_list": "", "function": "CALCOCO1 acts with VAMP-associated proteins to mediate ER-phagy., [RefSeq, PubMed]; CoCoA and CCAR1 appear to relay the GATA1 signal to MED1, and multiple modes of the GATA1-MED1 axis may help to fine-tune GATA1 function during GATA1-mediated homeostasis events. Erratum:[Genes Cells. 2023 Jan;28(1):78. doi: 10.1111/gtc.12991. PMID: 36647803], [RefSeq, PubMed]; Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions. In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Mass spectrometry proteomics reveals a function for mammalian CALCOCO1 in MTOR-regulated selective autophagy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5DTX0;Q9D935", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0000785 chromatin;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007165 signal transduction;GO:0010628 positive regulation of gene expression;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8CGU1-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BRN9-1", "uniprot_id": [ { "id": "C2D1B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BRN9", "type": "external" } ], "mass": 93091.0, "length": 848, "protein_name": "Coiled-coil and C2 domain-containing protein 1B", "gene_name": "Cc2d1b", "organism": "Mouse", "refseq_name": "coiled-coil and C2 domain-containing protein 1B", "refseq_ac": [ { "id": "NP_796019", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796019", "type": "external" } ], "gene_names_uniprotkb": "Cc2d1b; Kiaa1836", "gene_names_refseq": "A830039B04Rik; Cc2d1b; Freud2", "protein_names_uniprotkb": "Coiled-coil and C2 domain-containing protein 1B; FRE under dual repression-binding protein 2; Five prime repressor element under dual repression-binding protein 2; Freud-2", "protein_names_refseq": "FRE under dual repression-binding protein 2; coiled-coil and C2 domain-containing protein 1B; five prime repressor element under dual repression-binding protein 2; freud-2", "tax_id": 10090, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888)", "pathway": " (mmu:319965); (R-MMU-9668328)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "17084358;21155902;21183079;21750661;25428506;26495903", "class_list": "", "function": "Data show that Freud-2 is the second component that, with Freud-1, mediates dual repression of the 5-HT1A receptor gene at the dual repressor element., [RefSeq, PubMed]; Paper describes a function of Cc2d1b/Cc2d1a and its Drosophila homologue l(2)gd in D.melanogaster in Notch trafficking., [RefSeq, PubMed]; Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RQ40;Q3UJ60;Q69Z95", "ec_number_list": [], "go_molecular_function": "GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0010008 endosome membrane", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BRN9-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88665-1", "uniprot_id": [ { "id": "BRD7_MOUSE", "url": "https://www.uniprot.org/uniprot/O88665", "type": "external" } ], "mass": 74000.0, "length": 651, "protein_name": "Bromodomain-containing protein 7", "gene_name": "Brd7", "organism": "Mouse", "refseq_name": "bromodomain-containing protein 7 isoform 1", "refseq_ac": [ { "id": "NP_036177", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036177", "type": "external" } ], "gene_names_uniprotkb": "Brd7; Bp75", "gene_names_refseq": "BP75; Brd7; CELTIX1; Ptpn13ip", "protein_names_uniprotkb": "Bromodomain-containing protein 7; 75 kDa bromodomain protein", "protein_names_refseq": "75 kDa bromodomain protein; bromodomain protein 75 kDa; bromodomain-containing protein 7 isoform 1; bromodomain-containing protein 7; protein tyrosine phosphatase, non-receptor type 13 interacting protein", "tax_id": 10090, "disease": "colorectal carcinoma (Disease Ontology:DOID:0080199); alcohol use disorder (Disease Ontology:DOID:1574); ovary epithelial cancer (Disease Ontology:DOID:2152); glioblastoma (Disease Ontology:DOID:3068); malignant astrocytoma (Disease Ontology:DOID:3069); high grade glioma (Disease Ontology:DOID:3070); lung non-small cell carcinoma (Disease Ontology:DOID:3908); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (mmu:26992); (R-MMU-6804758); (R-MMU-9933939)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10526152;12941796;18809673;19909775;21183079;21750661;23806337;37578842;38992588", "class_list": "", "function": "Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase (By similarity). Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR., [UniProtKB, PubMed, PubMed, PubMed]; BRD7 facilitates ferroptosis via modulating clusterin promoter hypermethylation and suppressing AMPK signaling in diabetes-induced testicular damage. Publication Status: Online-Only, [RefSeq, PubMed]; BRD7 improves glucose homeostasis independent of IRS proteins. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UQ56;Q3UU06;Q9CT78", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003714 transcription corepressor activity;GO:0000976 transcription cis-regulatory region binding;GO:0042393 histone binding;GO:0002039 p53 binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016363 nuclear matrix;GO:0000776 kinetochore", "go_biological_process": "GO:2000819 regulation of nucleotide-excision repair;GO:0006338 chromatin remodeling;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O88665-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88737-1", "uniprot_id": [ { "id": "BSN_MOUSE", "url": "https://www.uniprot.org/uniprot/O88737", "type": "external" } ], "mass": 418843.0, "length": 3942, "protein_name": "Protein bassoon", "gene_name": "Bsn", "organism": "Mouse", "refseq_name": "protein bassoon", "refseq_ac": [ { "id": "NP_031593", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031593", "type": "external" } ], "gene_names_uniprotkb": "Bsn; Kiaa0434", "gene_names_refseq": "Bsn", "protein_names_uniprotkb": "Protein bassoon", "protein_names_refseq": "presynaptic cytomatrix protein; protein bassoon", "tax_id": 10090, "disease": "epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:12217)", "pathway_count": 1, "publication_count": 30, "publication_id_list": "10.3389/fragi.2021.757801;12628168;12628169;16452087;16452088;17114649;17869247;19458039;19812333;21158410;21183079;21750661;22517741;22645316;22826440;24129315;25428506;26192747;27558639;28231469;28657654;32782141;32848054;33300544;34678516;35822049;36757814;40021952;40885482;9679147", "class_list": "", "function": "Deficiency of Bassoon, a major component of the photoreceptor ribbon, results in impaired photoreceptor synaptic transmission, abnormal dendritic branching of neurons postsynaptic to photoreceptors, and the formation of ectopic synapses., [RefSeq, PubMed]; Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (PubMed:12628168, PubMed:12628169, PubMed:19812333). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (By similarity). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Also functions in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy by associating with ATG5 (By similarity) (PubMed:28231469). Also mediates synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (By similarity). Inhibits the activity of the proportion of DAO enzyme that localizes to the presynaptic active zone, which may modulate synaptic transmission (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 0, "predicted_o_glycosites": 6, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 13, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 283, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 283, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 283, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 25, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 17, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 289, "binding_glycan_count": 0, "secondary_ac_list": "E9QMZ3;Q6ZQB5", "ec_number_list": [], "go_molecular_function": "GO:0098882 structural constituent of presynaptic active zone;GO:0004857 enzyme inhibitor activity;GO:0008270 zinc ion binding;GO:0045503 dynein light chain binding;GO:0001222 transcription corepressor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0098831 presynaptic active zone cytoplasmic component;GO:1990257 piccolo-bassoon transport vesicle;GO:0005798 Golgi-associated vesicle", "go_biological_process": "GO:0008090 retrograde axonal transport;GO:0097091 synaptic vesicle clustering;GO:0008088 axo-dendritic transport;GO:0050808 synapse organization;GO:0050804 modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 31.5, "record_id": "O88737-1", "record_type": "protein", "filter_code": "0000000.1000111.001000.000000000000100000.0100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23589-1", "uniprot_id": [ { "id": "CAH5A_MOUSE", "url": "https://www.uniprot.org/uniprot/P23589", "type": "external" } ], "mass": 34072.0, "length": 299, "protein_name": "Carbonic anhydrase 5A, mitochondrial", "gene_name": "Ca5a", "organism": "Mouse", "refseq_name": "carbonic anhydrase 5A, mitochondrial precursor", "refseq_ac": [ { "id": "NP_031634", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031634", "type": "external" } ], "gene_names_uniprotkb": "Ca5a; Ca5; Car5a; Car5", "gene_names_refseq": "CAV; Ca5a; Car5a; Car5", "protein_names_uniprotkb": "Carbonic anhydrase 5A, mitochondrial; 4.2.1.1; CA Y; CA-VA; Carbonate dehydratase VA; Carbonic anhydrase VA", "protein_names_refseq": "CA Y; CA-VA; carbonate dehydratase VA; carbonic anhydrase 5, mitochondrial; carbonic anhydrase 5A, mitochondrial precursor; carbonic anhydrase 5b, mitochondrial; carbonic anhydrase VA", "tax_id": 10090, "disease": "", "pathway": " (mmu:12352); (R-MMU-1475029)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "11851394;2109313;23589845;23806337;28131914;36464834;7479916;7937950;8794740;9882455", "class_list": "", "function": "Both Car5A and Car5B contribute to both ammonia detoxification (ureagenesis) and regulation of fasting blood sugar (gluconeogenesis)., [RefSeq, PubMed]; In this report, genetic knockdown and overexpression studies confirm that mitochondrial CA VA regulates respiration in pericytes, whereas mitochondrial CA VB does not contribute significantly. Identification of mitochondrial CA VA as a sole regulator of respiration provides a specific target to develop new drugs with fewer side effects that may be better tolerated and can protect the brain from diabetic injury., [RefSeq, PubMed]; Mitochondrial carbonic anhydrase VA and VB: properties and roles in health and disease. Review article, [RefSeq, PubMed]; Mitochondrial carbonic anhydrase that catalyzes the reversible conversion of carbon dioxide to bicarbonate/HCO3 (PubMed:7937950). Mitochondria are impermeable to HCO3, and thus this intramitochondrial carbonic anhydrase is pivotal in providing HCO3 for multiple mitochondrial enzymes that catalyze the formation of essential metabolites of intermediary metabolism in the urea and Krebs cycles (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.2.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.1", "type": "external" }, { "id": "4.2.1.69", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.69", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004089 carbonate dehydratase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P23589-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41183-1", "uniprot_id": [ { "id": "BCL6_MOUSE", "url": "https://www.uniprot.org/uniprot/P41183", "type": "external" } ], "mass": 78982.0, "length": 707, "protein_name": "B-cell lymphoma 6 protein homolog", "gene_name": "Bcl6", "organism": "Mouse", "refseq_name": "B-cell lymphoma 6 protein homolog isoform 1", "refseq_ac": [ { "id": "NP_001334955", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334955", "type": "external" } ], "gene_names_uniprotkb": "Bcl6; Bcl-6", "gene_names_refseq": "Bcl5; Bcl6", "protein_names_uniprotkb": "B-cell lymphoma 6 protein homolog", "protein_names_refseq": "B-cell leukemia/lymphoma 5; B-cell lymphoma 6 protein homolog isoform 1; B-cell lymphoma 6 protein homolog", "tax_id": 10090, "disease": "diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745); B-cell lymphoma (Disease Ontology:DOID:707)", "pathway": " (mmu:12053)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10981963;12021781;17828269;21183079;23160044;23166356;23455674;23911289;34428180;34887587;7478591;8652841;9632807;9927193", "class_list": "", "function": "Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunoglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q61065", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005794 Golgi apparatus;GO:0005657 replication fork", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006954 inflammatory response;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P41183-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3V3R1-1", "uniprot_id": [ { "id": "C1TM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3V3R1", "type": "external" } ], "mass": 105729.0, "length": 977, "protein_name": "Monofunctional C1-tetrahydrofolate synthase, mitochondrial", "gene_name": "Mthfd1l", "organism": "Mouse", "refseq_name": "monofunctional C1-tetrahydrofolate synthase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001164256", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164256", "type": "external" } ], "gene_names_uniprotkb": "Mthfd1l; Fthfsdc1", "gene_names_refseq": "2410004L15Rik; Fthfsdc1; Mthfd1l", "protein_names_uniprotkb": "Monofunctional C1-tetrahydrofolate synthase, mitochondrial; 6.3.4.3; Formyltetrahydrofolate synthetase", "protein_names_refseq": "formyltetrahydrofolate synthetase domain containing 1; monofunctional C1-tetrahydrofolate synthase, mitochondrial precursor; monofunctional C1-tetrahydrofolate synthase, mitochondrial", "tax_id": 10090, "disease": "neural tube defect (Disease Ontology:DOID:0080074)", "pathway": " (mmu:270685); (R-MMU-196757)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "15611115;19948730;23267094;23806337;25428506;35820727;38682273;39627609;40684658", "class_list": "", "function": "Data show that the MTHFD1L enzyme is present in mitochondria from normal embryonic tissues and embryonic fibroblast cell lines, and embryonic mitochondria possess the ability to synthesize formate from glycine., [RefSeq, PubMed]; Deletion of Mthfd1l causes embryonic lethality and neural tube and craniofacial defects in mice., [RefSeq, PubMed]; May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism complementing thus the enzymatic activities of MTHFD2., [UniProtKB, PubMed]; Optical coherence tomography-guided Brillouin microscopy highlights regional tissue stiffness differences during anterior neural tube closure in the Mthfd1l murine mutant., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TVQ0;Q3V402;Q80V98;Q8CAL0;Q8K2N5", "ec_number_list": [ { "id": "6.3.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.3", "type": "external" }, { "id": "1.5.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.5", "type": "external" }, { "id": "3.5.4.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.9", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0004329 formate-tetrahydrofolate ligase activity;GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol", "go_biological_process": "GO:0001843 neural tube closure;GO:0006760 folic acid-containing compound metabolic process;GO:0009257 10-formyltetrahydrofolate biosynthetic process;GO:0015942 formate metabolic process;GO:0035999 tetrahydrofolate interconversion", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q3V3R1-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63810-1", "uniprot_id": [ { "id": "CANB1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q63810", "type": "external" } ], "mass": 19300.0, "length": 170, "protein_name": "Calcineurin subunit B type 1", "gene_name": "Ppp3r1", "organism": "Mouse", "refseq_name": "calcineurin subunit B type 1", "refseq_ac": [ { "id": "NP_077779", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077779", "type": "external" } ], "gene_names_uniprotkb": "Ppp3r1; Cnb", "gene_names_refseq": "CaNB1; Cnb1; MCIP1; Ppp3r1", "protein_names_uniprotkb": "Calcineurin subunit B type 1; Protein phosphatase 2B regulatory subunit 1; Protein phosphatase 3 regulatory subunit B alpha isoform 1", "protein_names_refseq": "PP2B beta 1; calcineurin subunit B type 1; protein phosphatase 2B regulatory subunit 1; protein phosphatase 3 regulatory subunit B alpha", "tax_id": 10090, "disease": "traumatic brain injury (Disease Ontology:DOID:0081292); Alzheimer's disease (Disease Ontology:DOID:10652); dilated cardiomyopathy (Disease Ontology:DOID:12930); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:19058); (R-MMU-111447); (R-MMU-2025928); (R-MMU-2871809); (R-MMU-4086398); (R-MMU-5607763)", "pathway_count": 6, "publication_count": 8, "publication_id_list": "1325794;16286645;18034455;20639889;26740625;26794871;34428180;38288580", "class_list": "", "function": "Genetic deletion of astrocytic calcineurin B1 prevents cognitive impairment and neuropathology development in acute and chronic mouse models of Alzheimer's disease., [RefSeq, PubMed]; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V067;Q5F225", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0019904 protein domain specific binding;GO:0005509 calcium ion binding;GO:0019902 phosphatase binding;GO:0004721 phosphoprotein phosphatase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0045202 synapse;GO:0098794 postsynapse;GO:0042383 sarcolemma", "go_biological_process": "GO:0007507 heart development;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006470 protein dephosphorylation;GO:0034504 protein localization to nucleus;GO:0001569 branching involved in blood vessel morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q63810-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80TJ1-1", "uniprot_id": [ { "id": "CAPS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80TJ1", "type": "external" } ], "mass": 153113.0, "length": 1355, "protein_name": "Calcium-dependent secretion activator 1", "gene_name": "Cadps", "organism": "Mouse", "refseq_name": "calcium-dependent secretion activator 1 isoform 2", "refseq_ac": [ { "id": "NP_001036082", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036082", "type": "external" } ], "gene_names_uniprotkb": "Cadps; Caps1; Caps; Kiaa1121", "gene_names_refseq": "CAPS1; CAPS; Cadps; mKIAA1121", "protein_names_uniprotkb": "Calcium-dependent secretion activator 1; CAPS-1; Calcium-dependent activator protein for secretion 1", "protein_names_refseq": "Ca2+-dependent activator protein for secretion; Ca<2+>dependent activator protein for secretion; calcium-dependent activator protein for secretion 1; calcium-dependent secretion activator 1 isoform 2; calcium-dependent secretion activator 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:27062)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "14530279;15820687;15820695;16506193;17984325;21183079;21750661;30084848;32160535;32848054;33300544;33883618;33894004;34418053;35169262;35820727", "class_list": "", "function": "CADPS functional mutations in patients with bipolar disorder increase the sensitivity to stress., [RefSeq, PubMed]; CAPS1 is involved in hippocampal synaptic plasticity and hippocampus-associated learning. Publication Status: Online-Only, [RefSeq, PubMed]; Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering (By similarity)., [UniProtKB, PubMed]; RNA editing-mediated regulation of calcium-dependent activator protein for secretion (CAPS1) localization and its impact on synaptic transmission., [RefSeq, PubMed]; The Synaptic Vesicle Priming Protein CAPS-1 Shapes the Adaptation of Sensory Evoked Responses in Mouse Visual Cortex., [RefSeq, PubMed]; The two CAPS family proteins are complementarily distributed throughout the various brain regions of mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "E9QN90;Q3TSP2;Q61374;Q6AXB4;Q6PGF0", "ec_number_list": [], "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0019901 protein kinase binding;GO:0005509 calcium ion binding;GO:0008289 lipid binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0031410 cytoplasmic vesicle;GO:0098793 presynapse;GO:0098674 extrinsic component of neuronal dense core vesicle membrane", "go_biological_process": "GO:0015031 protein transport;GO:0016050 vesicle organization;GO:0006887 exocytosis;GO:0017156 calcium-ion regulated exocytosis;GO:0016082 synaptic vesicle priming", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q80TJ1-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R464-1", "uniprot_id": [ { "id": "CADM4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R464", "type": "external" } ], "mass": 42723.0, "length": 388, "protein_name": "Cell adhesion molecule 4", "gene_name": "Cadm4", "organism": "Mouse", "refseq_name": "cell adhesion molecule 4 precursor", "refseq_ac": [ { "id": "NP_694752", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694752", "type": "external" } ], "gene_names_uniprotkb": "Cadm4; Igsf4c; Necl4; Tsll2", "gene_names_refseq": "Cadm4; Igdf4c; Igsf4c; Tsll2", "protein_names_uniprotkb": "Cell adhesion molecule 4; IgSF4C; Immunoglobulin superfamily member 4C; NECL-4; Nectin-like protein 4; TSLC1-like protein 2", "protein_names_refseq": "NECL-4; SynCAM 4; TSLC1-like 2; TSLC1-like protein 2; cell adhesion molecule 4 precursor; immunoglobulin superfamily, member 4C; membrane glycoprotein Tsll2; nectin-like protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:260299)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;14659875;16261159;21183079;30779550;30899004;33300544;35445918;37184041;39327467", "class_list": "", "function": "Age-Dependent Increase in Schmidt-Lanterman Incisures and a Cadm4-Associated Membrane Skeletal Complex in Fatty Acid 2-hydroxylase Deficient Mice: a Mouse Model of Spastic Paraplegia SPG35., [RefSeq, PubMed]; Cell adhesion molecule, exhibiting calcium- and magnesium-independent cell-cell adhesion activity (PubMed:14659875). In its palmitoylated form, is required for proper oligodendrocyte maturation and myelination in CNS via its association with other cell adhesion molecules such as CADM2/3 and MAG (PubMed:39327467). May have tumor-suppressor activity (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; Indispensable role of Nectin-like 4 in regulating synapse-related molecules, synaptic structure, and individual behavior., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 16, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043183 vascular endothelial growth factor receptor 1 binding;GO:0030971 receptor tyrosine kinase binding;GO:0019903 protein phosphatase binding;GO:0043184 vascular endothelial growth factor receptor 2 binding", "go_cellular_component": "GO:0031252 cell leading edge;GO:0097060 synaptic membrane;GO:0044291 cell-cell contact zone", "go_biological_process": "GO:0061041 regulation of wound healing;GO:0042127 regulation of cell population proliferation;GO:2000145 regulation of cell motility;GO:0001933 negative regulation of protein phosphorylation;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "Q8R464-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.1100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R5M8-1", "uniprot_id": [ { "id": "CADM1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R5M8", "type": "external" } ], "mass": 49788.0, "length": 456, "protein_name": "Cell adhesion molecule 1", "gene_name": "Cadm1", "organism": "Mouse", "refseq_name": "cell adhesion molecule 1 isoform d precursor", "refseq_ac": [ { "id": "NP_001020771", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020771", "type": "external" } ], "gene_names_uniprotkb": "Cadm1; Igsf4; Necl2; Ra175; SynCam1; Syncam; Tslc1", "gene_names_refseq": "2900073G06Rik; 3100001I08Rik; Bl2; Cadm1; Igsf4a; Igsf4; Necl2; RA175A; RA175B; RA175C; RA175N; RA175; ST17; SgIGSF; SynCam; Tslc1", "protein_names_uniprotkb": "Cell adhesion molecule 1; IgSF4; Immunoglobulin superfamily member 4; NECL-2; Nectin-like protein 2; SgIgSF; Spermatogenic immunoglobulin superfamily; SynCAM; Synaptic cell adhesion molecule; TSLC-1; Tumor suppressor in lung cancer 1", "protein_names_refseq": "NECL-2; TSLC-1; cell adhesion molecule 1 isoform d precursor; immunoglobulin superfamily member 4A; immunosuperfamily protein Bl2; nectin-like 2; nectin-like protein 2; spermatogenic immunoglobulin superfamily; synaptic cell adhesion molecule; tumor suppressor in lung cancer 1", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); breast carcinoma (Disease Ontology:DOID:3459); lung adenocarcinoma (Disease Ontology:DOID:3910); hepatocellular carcinoma (Disease Ontology:DOID:684); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991)", "pathway": " (mmu:54725); (R-MMU-418990); (R-MMU-420597)", "pathway_count": 3, "publication_count": 31, "publication_id_list": "10.1101/2023.09.13.557529;12202822;12242005;12606335;12799182;12826663;15158462;15707673;15781451;15811952;15893517;16382161;16605125;16611999;16612000;18322192;19144319;19349973;19656770;19752223;20739279;21183079;21750661;23209303;24687959;26495903;26740625;30899004;35820727;36709330;36872374", "class_list": "", "function": "Concerted roles of LRRTM1 and SynCAM 1 in organizing prefrontal cortex synapses and cognitive functions. Publication Status: Online-Only, [RefSeq, PubMed]; Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner (PubMed:12202822, PubMed:12799182, PubMed:12826663). Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner (PubMed:12826663). Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ T-cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo (PubMed:15811952). In mast cells, may mediate attachment to and promote communication with nerves (By similarity). CADM1, together with MITF, is essential for development and survival of mast cells in vivo (PubMed:15158462, PubMed:16605125). By interacting with CRTAM and thus promoting the adhesion between CD8+ T-cells and CD8+ dendritic cells, regulates the retention of activated CD8+ T-cell within the draining lymph node (PubMed:19752223). Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells (PubMed:24687959). Interaction with CRTAM promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells (PubMed:24687959). Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly (PubMed:12202822, PubMed:23209303). May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons (PubMed:15707673). May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa (PubMed:12606335, PubMed:16612000)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; NECL2 regulates blood-testis barrier dynamics in mouse testes., [RefSeq, PubMed]; SynCAM1 is expressed in brain and localized to pre- and postsynaptic sites of neurons. SynCAM1 is a homophilic cell adhesion molecule that induces formation of presynaptic terminals by neurons., [RefSeq, PubMed]; The Tslc1 gene is mapped on mouse chromosome 9, a synteny of human chromosome 11q, and is composed of ten exons, the exon-intron junctions being highly conserved between human and mouse., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 10, "disease_count": 5, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q6F3J3;Q7TNL1;Q80VG4;Q8K3T6;Q8R4L1;Q9QYL5;Q9QYL6;Q9Z2H8", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0050839 cell adhesion molecule binding;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0014069 postsynaptic density;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0099054 presynapse assembly;GO:0098942 retrograde trans-synaptic signaling by trans-synaptic protein complex;GO:0001889 liver development;GO:0007155 cell adhesion;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 4.8, "record_id": "Q8R5M8-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q921K9-1", "uniprot_id": [ { "id": "BCL7B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q921K9", "type": "external" } ], "mass": 22238.0, "length": 202, "protein_name": "B-cell CLL/lymphoma 7 protein family member B", "gene_name": "Bcl7b", "organism": "Mouse", "refseq_name": "B-cell CLL/lymphoma 7 protein family member B", "refseq_ac": [ { "id": "NP_033875", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033875", "type": "external" } ], "gene_names_uniprotkb": "Bcl7b", "gene_names_refseq": "Bcl7b", "protein_names_uniprotkb": "B-cell CLL/lymphoma 7 protein family member B", "protein_names_refseq": "B-cell CLL/lymphoma 7 protein family member B", "tax_id": 10090, "disease": "", "pathway": " (mmu:12054); (R-MMU-9933937); (R-MMU-9933939); (R-MMU-9933946); (R-MMU-9933947); (R-MMU-9934037)", "pathway_count": 6, "publication_count": 9, "publication_id_list": "14647414;17242355;19144319;21183079;21750661;32848054;36852467;40997131;9931421", "class_list": "", "function": "Positive regulator of apoptosis. Plays a role in the Wnt signaling pathway, negatively regulating the expression of Wnt signaling components CTNNB1 and HMGA1 (By similarity). Involved in cell cycle progression, maintenance of the nuclear structure and stem cell differentiation (By similarity). May play a role in lung tumor development or progression., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O89022;Q3TV31;Q3U2W0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016514 SWI/SNF complex;GO:0000785 chromatin", "go_biological_process": "GO:1902459 positive regulation of stem cell population maintenance;GO:2000819 regulation of nucleotide-excision repair;GO:0006338 chromatin remodeling;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q921K9-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99PF4-1", "uniprot_id": [ { "id": "CAD23_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99PF4", "type": "external" } ], "mass": 369623.0, "length": 3354, "protein_name": "Cadherin-23", "gene_name": "Cdh23", "organism": "Mouse", "refseq_name": "cadherin-23 isoform 1 precursor", "refseq_ac": [ { "id": "NP_075859", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075859", "type": "external" } ], "gene_names_uniprotkb": "Cdh23", "gene_names_refseq": "4930542A03Rik; Cdh23; USH1D; ahl1; ahl; bob; bus; mdfw; nmf112; nmf181; nmf252; sals; v", "protein_names_uniprotkb": "Cadherin-23; Otocadherin", "protein_names_refseq": "age related hearing loss 1; bobby; bustling; cadherin 23 (otocadherin); cadherin-23 isoform 1 precursor; cadherin-23; modifier of deaf waddler; otocadherin; waltzer", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness (Disease Ontology:DOID:0050565); autosomal recessive nonsyndromic deafness 12 (Disease Ontology:DOID:0110467); Usher syndrome type 1D (Disease Ontology:DOID:0110831); pituitary adenoma 5 (Disease Ontology:DOID:0112008)", "pathway": " (mmu:22295)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;11138008;11386759;11750125;15882574;17805295;20399731;20498078;21750661;23135401;27349180", "class_list": "", "function": "Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 33, "predicted_n_glycosites": 33, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 9, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 10, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 10, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 10, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 7, "reported_interactions": 0, "missing_score": 9781, "biomarker_type": "", "glycan_count": 7, "disease_count": 4, "glyco_site_count": 43, "binding_glycan_count": 0, "secondary_ac_list": "E9QP63;Q5QGS3;Q5QGS4;Q5QGS7;Q5QGS8;Q99NH1;Q9D4N9", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005886 plasma membrane;GO:0045177 apical part of cell;GO:0045202 synapse;GO:0001917 photoreceptor inner segment", "go_biological_process": "GO:0042491 inner ear auditory receptor cell differentiation;GO:0007155 cell adhesion;GO:0007626 locomotory behavior;GO:0016477 cell migration;GO:0031175 neuron projection development", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q99PF4-1", "record_type": "protein", "filter_code": "0000000.1100111.001000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQM1-1", "uniprot_id": [ { "id": "CA210_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQM1", "type": "external" } ], "mass": 11532.0, "length": 111, "protein_name": "Type III endosome membrane protein TEMP", "gene_name": "", "organism": "Mouse", "refseq_name": "type III endosome membrane protein TEMP", "refseq_ac": [ { "id": "NP_079848", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079848", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "2610528J11Rik; TEMP", "protein_names_uniprotkb": "Type III endosome membrane protein TEMP; TEMP", "protein_names_refseq": "type III endosome membrane protein TEMP", "tax_id": 10090, "disease": "", "pathway": " (mmu:66451)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "24710541;34428180", "class_list": "", "function": "May be involved in membrane trafficking between endosomes and plasma membrane., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0055037 recycling endosome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CQM1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D3A8-1", "uniprot_id": [ { "id": "CAPON_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D3A8", "type": "external" } ], "mass": 55873.0, "length": 503, "protein_name": "Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein", "gene_name": "Nos1ap", "organism": "Mouse", "refseq_name": "carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein isoform 1", "refseq_ac": [ { "id": "NP_001103455", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103455", "type": "external" } ], "gene_names_uniprotkb": "Nos1ap; Capon; Kiaa0464", "gene_names_refseq": "6330408P19Rik; Capon; Nos1ap", "protein_names_uniprotkb": "Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein; C-terminal PDZ ligand of neuronal nitric oxide synthase protein; Nitric oxide synthase 1 adaptor protein", "protein_names_refseq": "C-terminal PDZ domain ligand of neuronal nitric oxide synthase; C-terminal PDZ ligand of neuronal nitric oxide synthase protein; carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein isoform 1; carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein", "tax_id": 10090, "disease": "nephrotic syndrome type 22 (Disease Ontology:DOID:0112268); sciatic neuropathy (Disease Ontology:DOID:11446); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); depressive disorder (Disease Ontology:DOID:1596); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (mmu:70729)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11086993;15561099;17242355;19114050;21183079;21750661;33523862;34428180;36513018;37708408", "class_list": "", "function": "Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity). In kidney podocytes, plays a role in podosomes and filopodia formation through CDC42 activation (PubMed:33523862)., [UniProtKB, PubMed, UniProtKB]; Capon expression is increased in skeletal muscle by position, repair, NOS activity, and dystrophy., [RefSeq, PubMed]; Cardiac muscle-restricted partial loss of Nos1ap expression has limited but significant impact on electrocardiographic features., [RefSeq, PubMed]; Disrupting the nNOS/NOS1AP interaction in the medial prefrontal cortex impairs social recognition and spatial working memory in mice., [RefSeq, PubMed]; Long-term expression of cocaine-induced behavioral sensitization in females (adolescent and adult) is nNOS-independent, unlike previous finding in adult males., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9Q7B9;Q80TZ6", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0031434 mitogen-activated protein kinase kinase binding;GO:0030165 PDZ domain binding;GO:0050998 nitric-oxide synthase binding;GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0031965 nuclear membrane", "go_biological_process": "GO:0098974 postsynaptic actin cytoskeleton organization;GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization;GO:0003062 regulation of heart rate by chemical signal", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9D3A8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTL8-1", "uniprot_id": [ { "id": "BMAL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WTL8", "type": "external" } ], "mass": 69452.0, "length": 632, "protein_name": "Basic helix-loop-helix ARNT-like protein 1", "gene_name": "Bmal1", "organism": "Mouse", "refseq_name": "basic helix-loop-helix ARNT-like protein 1 isoform 2", "refseq_ac": [ { "id": "NP_001229977", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001229977", "type": "external" } ], "gene_names_uniprotkb": "Bmal1; Arntl", "gene_names_refseq": "Arnt3; Arntl; BMAL1b; Bmal1; MOP3; bHLHe5; bmal1b'", "protein_names_uniprotkb": "Basic helix-loop-helix ARNT-like protein 1; Arnt3; Aryl hydrocarbon receptor nuclear translocator-like protein 1; Brain and muscle ARNT-like 1", "protein_names_refseq": "aryl hydrocarbon receptor nuclear translocator-like protein 1; basic helix-loop-helix ARNT-like protein 1 isoform 2; basic helix-loop-helix ARNT-like protein 1; brain and muscle ARNT-like 1", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); cholestasis (Disease Ontology:DOID:13580); bipolar disorder (Disease Ontology:DOID:3312); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (mmu:11865); (R-MMU-9768919)", "pathway_count": 2, "publication_count": 91, "publication_id_list": "10403839;11779462;12397359;12897057;14672706;16109848;16628007;16717091;16790549;16980631;18075593;18258755;18316400;18430226;18644859;18662546;18662547;19141540;19286518;19299583;19330005;19414601;19605937;19946213;20049328;20093473;20106950;20153195;20385766;20430893;20562852;20658528;20840750;20861012;20956306;21113167;21613214;21750661;21768648;21960634;21966465;22045262;22069332;22101268;22208286;22611086;22653727;22894897;22900038;22981862;23185022;23291174;23303907;23337503;23395176;23525013;23531614;23547261;23576606;23750248;23831463;23916625;23955654;23970558;24043798;24048828;24089055;24154698;24268780;24270424;24378737;24385426;24395244;24442997;24481314;24529706;24603368;24736997;26776516;27576939;28903391;28985504;29138967;29626158;29937374;29996098;30096135;31294688;39375536;9616112;9704006", "class_list": "", "function": "The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with Clock. This heterodimer binds E-box enhancer elements upstream of Period (Per1, Per2, Per3) and Cryptochrome (Cry1, Cry2) genes and activates transcription of these genes. Per and Cry proteins heterodimerize and repress their own transcription by interacting in a feedback loop with Clock/Arntl complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2014]., [RefSeq]; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. BMAL1 positively regulates myogenesis and negatively regulates adipogenesis via the transcriptional control of the genes of the canonical Wnt signaling pathway. Plays a role in normal pancreatic beta-cell function; regulates glucose-stimulated insulin secretion via the regulation of antioxidant genes NFE2L2/NRF2 and its targets SESN2, PRDX3, CCLC and CCLM. Negatively regulates the mTORC1 signaling pathway; regulates the expression of MTOR and DEPTOR. Controls diurnal oscillations of Ly6C inflammatory monocytes; rhythmic recruitment of the PRC2 complex imparts diurnal variation to chemokine expression that is necessary to sustain Ly6C monocyte rhythms. Regulates the expression of HSD3B2, STAR, PTGS2, CYP11A1, CYP19A1 and LHCGR in the ovary and also the genes involved in hair growth. Plays an important role in adult hippocampal neurogenesis by regulating the timely entry of neural stem/progenitor cells (NSPCs) into the cell cycle and the number of cell divisions that take place prior to cell-cycle exit. Regulates the circadian expression of CIART and KLF11. The CLOCK-BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and also genes implicated in glucose and lipid metabolism. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. May play a role in spermatogenesis; contributes to the chromatoid body assembly and physiology. The NPAS2-BMAL1 heterodimer positively regulates the expression of MAOA, F7 and LDHA and modulates the circadian rhythm of daytime contrast sensitivity by regulating the rhythmic expression of adenylate cyclase type 1 (ADCY1) in the retina. The preferred binding motif for the CLOCK-BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking adenine nucleotide at the 3-prime end of the canonical 6-nucleotide E-box sequence (By similarity). CLOCK specifically binds to the half-site 5'-CAC-3', while BMAL1 binds to the half-site 5'-GTGA-3' (By similarity). The CLOCK-BMAL1 heterodimer also recognizes the non-canonical E-box motifs 5'-AACGTGA-3' and 5'-CATGTGA-3' (By similarity). Essential for the rhythmic interaction of CLOCK with ASS1 and plays a critical role in positively regulating CLOCK-mediated acetylation of ASS1 (PubMed:28985504). Plays a role in protecting against lethal sepsis by limiting the expression of immune checkpoint protein CD274 in macrophages in a PKM2-dependent manner (PubMed:29996098). Regulates the diurnal rhythms of skeletal muscle metabolism via transcriptional activation of genes promoting triglyceride synthesis (DGAT2) and metabolic efficiency (COQ10B) (PubMed:30096135)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 16, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O88295;Q921S4;Q9R0U2;Q9WTL9", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0046982 protein heterodimerization activity;GO:0017162 aryl hydrocarbon receptor binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:1990513 CLOCK-BMAL transcription complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:1901985 positive regulation of protein acetylation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 9.5, "record_id": "Q9WTL8-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2F7-1", "uniprot_id": [ { "id": "BNI3L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z2F7", "type": "external" } ], "mass": 23766.0, "length": 218, "protein_name": "BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like", "gene_name": "Bnip3l", "organism": "Mouse", "refseq_name": "BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform 1", "refseq_ac": [ { "id": "NP_033891", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033891", "type": "external" } ], "gene_names_uniprotkb": "Bnip3l; Nix", "gene_names_refseq": "Bnip3l; D14Ertd719e; Nip3L; Nix", "protein_names_uniprotkb": "BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like; NIP3-like protein X; NIP3L", "protein_names_refseq": "BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform 1; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like; BCL2/adenovirus E1B 19 kDa-interacting protein 3-like; BCL2/adenovirus E1B 19kDa-interacting protein 3-like; NIP3-like protein X", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); gestational diabetes (Disease Ontology:DOID:11714); middle cerebral artery infarction (Disease Ontology:DOID:3525); pancreatitis (Disease Ontology:DOID:4989)", "pathway": " (mmu:12177); (R-MMU-6803204)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "12053174;17242355;21183079;28820284;31219806;34428180;9867803", "class_list": "", "function": "Induced in cardiac hypertrophy and triggers apoptotic cardiomyopathy, [RefSeq, PubMed]; Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity). May function as a tumor suppressor (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q545J6", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0005521 lamin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0043066 negative regulation of apoptotic process;GO:0051607 defense response to virus;GO:0071456 cellular response to hypoxia;GO:0016239 positive regulation of macroautophagy", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9Z2F7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62095-1", "uniprot_id": [ { "id": "DDX3Y_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62095", "type": "external" } ], "mass": 73428.0, "length": 658, "protein_name": "ATP-dependent RNA helicase DDX3Y", "gene_name": "Ddx3y", "organism": "Mouse", "refseq_name": "ATP-dependent RNA helicase DDX3Y", "refseq_ac": [ { "id": "NP_036138", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036138", "type": "external" } ], "gene_names_uniprotkb": "Ddx3y; D1Pas1-rs1; Dead2", "gene_names_refseq": "8030469F12Rik; D1Pas1-rs1; Dby; Ddx3y", "protein_names_uniprotkb": "ATP-dependent RNA helicase DDX3Y; 3.6.4.13; D1Pas1-related sequence 1; DEAD box protein 3, Y-chromosomal; DEAD-box RNA helicase DEAD2; mDEAD2", "protein_names_refseq": "ATP-dependent RNA helicase DDX3Y; D1Pas1 related sequence 1; DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked; DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide, Y chromosome; DEAD box protein 3, Y-chromosomal; DEAD-box RNA helicase DEAD2; mDEAD2", "tax_id": 10090, "disease": "Sertoli cell-only syndrome (Disease Ontology:DOID:0050457); childhood medulloblastoma (Disease Ontology:DOID:3869)", "pathway": " (mmu:26900)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "14662851;15383328;21183079;21490154;21750661;23056200;25428506;28528544;29662488;30084848;30475900;30613052;31219806;33300544;8144024;9736773", "class_list": "", "function": "Probable ATP-dependent RNA helicase. During immune response, may enhance IFNB1 expression via IRF3/IRF7 pathway (PubMed:30475900)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9QWS9", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0043186 P granule", "go_biological_process": "GO:0010629 negative regulation of gene expression;GO:0030154 cell differentiation;GO:0007276 gamete generation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q62095-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91XC8-1", "uniprot_id": [ { "id": "DAP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91XC8", "type": "external" } ], "mass": 11155.0, "length": 102, "protein_name": "Death-associated protein 1", "gene_name": "Dap", "organism": "Mouse", "refseq_name": "death-associated protein 1", "refseq_ac": [ { "id": "NP_666169", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666169", "type": "external" } ], "gene_names_uniprotkb": "Dap", "gene_names_refseq": "4921531N22Rik; Dap", "protein_names_uniprotkb": "Death-associated protein 1; DAP-1", "protein_names_refseq": "DAP-1; death-associated protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:223453)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17242355;19131326;21183079;21750661;23806337", "class_list": "", "function": "Ribosome-binding protein involved in ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation. Acts via its association with eiF5a (EIF5A and EIF5A2) at the polypeptide exit tunnel of the ribosome, preventing mRNA translation. Involved in ribosome hibernation in the mature oocyte by preventing mRNA translation, leading to ribosome inactivation. Ribosomes, which are produced in large quantities during oogenesis, are stored and translationally repressed in the oocyte and early embryo (By similarity). Also acts as a negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043022 ribosome binding", "go_cellular_component": "", "go_biological_process": "GO:0006915 apoptotic process;GO:0097190 apoptotic signaling pathway;GO:0006914 autophagy;GO:0010507 negative regulation of autophagy;GO:0141014 ribosome hibernation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q91XC8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54788-1", "uniprot_id": [ { "id": "DFFB_MOUSE", "url": "https://www.uniprot.org/uniprot/O54788", "type": "external" } ], "mass": 39449.0, "length": 344, "protein_name": "DNA fragmentation factor subunit beta", "gene_name": "Dffb", "organism": "Mouse", "refseq_name": "DNA fragmentation factor subunit beta", "refseq_ac": [ { "id": "NP_031885", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031885", "type": "external" } ], "gene_names_uniprotkb": "Dffb; Cad", "gene_names_refseq": "40kDa; 5730477D02Rik; CAD; CPAN; DFF40; Dffb; Didff", "protein_names_uniprotkb": "DNA fragmentation factor subunit beta; 3.-.-.-; CAD; Caspase-activated DNase; Caspase-activated deoxyribonuclease; DFF-40; DNA fragmentation factor 40 kDa subunit", "protein_names_refseq": "DFF-40; DNA fragmentation factor 40 kDa subunit; DNA fragmentation factor subunit beta; DNA fragmentation factor, 40 kD, beta subunit; DNase inhibited by DNA fragmentation factor; caspase-activated DNase; caspase-activated deoxyribonuclease", "tax_id": 10090, "disease": "transient cerebral ischemia (Disease Ontology:DOID:224)", "pathway": " (mmu:13368); (R-MMU-140342)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "21750661;30084848;30779550;31219806;31255286;38849575;9422506;9422513", "class_list": "", "function": "Cell-free DNA in blood circulation is generated by DNase1L3 and caspase-activated DNase., [RefSeq, PubMed]; Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology., [UniProtKB, UniProtKB, UniProtKB]; The Caspase-Activated DNase drives inflammation and contributes to defense against viral infection., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.-.-.-", "type": "external" }, { "id": "3.4.22.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.56", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0016787 hydrolase activity;GO:0019899 enzyme binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0000785 chromatin", "go_biological_process": "GO:0030263 apoptotic chromosome condensation;GO:0006309 apoptotic DNA fragmentation;GO:0006308 DNA catabolic process;GO:1902511 negative regulation of apoptotic DNA fragmentation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O54788-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2ATU0-1", "uniprot_id": [ { "id": "DHTK1_MOUSE", "url": "https://www.uniprot.org/uniprot/A2ATU0", "type": "external" } ], "mass": 102793.0, "length": 921, "protein_name": "2-oxoadipate dehydrogenase complex component E1", "gene_name": "Dhtkd1", "organism": "Mouse", "refseq_name": "2-oxoadipate dehydrogenase complex component E1", "refseq_ac": [ { "id": "NP_001074600", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074600", "type": "external" } ], "gene_names_uniprotkb": "Dhtkd1; Kiaa1630", "gene_names_refseq": "C330018I04Rik; Dhtkd1; E1a; OADC-E1; OADH-E1", "protein_names_uniprotkb": "2-oxoadipate dehydrogenase complex component E1; 1.2.4.-; 2-oxoadipate dehydrogenase, mitochondrial; Alpha-KADH-E1; Alpha-ketoadipate dehydrogenase; Dehydrogenase E1 and transketolase domain-containing protein 1; E1a; OADC-E1; OADH-E1; Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial", "protein_names_refseq": "2-oxoadipate dehydrogenase complex component E1; 2-oxoadipate dehydrogenase, mitochondrial; alpha-KADH-E1; alpha-ketoadipate dehydrogenase; dehydrogenase E1 and transketolase domain-containing protein 1; probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial", "tax_id": 10090, "disease": "Charcot-Marie-Tooth disease axonal type 2Q (Disease Ontology:DOID:0110170); 2-aminoadipic 2-oxoadipic aciduria (Disease Ontology:DOID:0111453)", "pathway": " (mmu:209692); (R-MMU-9858328)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;23806337;25215496;28545977;29661920;32169121;34428180", "class_list": "", "function": "2-oxoadipate dehydrogenase (E1a) component of the 2-oxoadipate dehydrogenase complex (OADHC). Participates in the first step, rate limiting for the overall conversion of 2-oxoadipate (alpha-ketoadipate) to glutaryl-CoA and CO(2) catalyzed by the whole OADHC. Catalyzes the irreversible decarboxylation of 2-oxoadipate via the thiamine diphosphate (ThDP) cofactor and subsequent transfer of the decarboxylated acyl intermediate on an oxidized dihydrolipoyl group that is covalently amidated to the E2 enzyme (dihydrolipoyllysine-residue succinyltransferase or DLST). Can catalyze the decarboxylation of 2-oxoglutarate in vitro, but at a much lower rate than 2-oxoadipate. Responsible for the last step of L-lysine, L-hydroxylysine and L-tryptophan catabolism with the common product being 2-oxoadipate., [UniProtKB, UniProtKB]; CMT2Q-causing mutation in the Dhtkd1 gene lead to sensory defects, mitochondrial accumulation and altered metabolism in a knock-in mouse model. Publication Status: Online-Only, [RefSeq, PubMed]; Dhtkd1(-/-) mice mimic the major aspects of CMT2 phenotypes, characterized by progressive weakness and atrophy in the distal parts of limbs with motor and sensory dysfunctions, which are accompanied with decreased nerve conduction velocity. Moreover, DHTKD1 deficiency causes severe metabolic abnormalities and dramatically increased levels of 2-ketoadipic acid (2-KAA) and 2-aminoadipic acid (2-AAA) in urine. Publication Status: Online-Only, [RefSeq, PubMed]; Elevated glutaric acid levels in Dhtkd1-/Gcdh- double knockout mice challenge our current understanding of lysine metabolism., [RefSeq, PubMed]; In the BXD mouse population, natural variants in Dhtkd1 lead to changes in metabolite levels of 2-aminoadipate and in turn are associated with diabetes status, independently of chow or high fat diet feeding., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q0VFY3;Q69ZE3;Q8BWT3", "ec_number_list": [ { "id": "1.2.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.-", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "2.3.1.61", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.61", "type": "external" } ], "go_molecular_function": "GO:0030976 thiamine pyrophosphate binding;GO:0160166 2-oxoadipate dehydrogenase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0160167 oxoadipate dehydrogenase complex", "go_biological_process": "GO:0006091 generation of precursor metabolites and energy;GO:0006096 glycolytic process;GO:0002244 hematopoietic progenitor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "A2ATU0-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6H8H2-1", "uniprot_id": [ { "id": "DEN4C_MOUSE", "url": "https://www.uniprot.org/uniprot/A6H8H2", "type": "external" } ], "mass": 211458.0, "length": 1906, "protein_name": "DENN domain-containing protein 4C", "gene_name": "Dennd4c", "organism": "Mouse", "refseq_name": "DENN domain-containing protein 4C isoform 1", "refseq_ac": [ { "id": "NP_908976", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_908976", "type": "external" } ], "gene_names_uniprotkb": "Dennd4c", "gene_names_refseq": "1700065A05Rik; Dennd4c", "protein_names_uniprotkb": "DENN domain-containing protein 4C", "protein_names_refseq": "DENN domain-containing protein 4C isoform 1; DENN domain-containing protein 4C; DENN/MADD domain containing 4C; likely ortholog of H. sapiens chromosome 9 open reading frame 55 (C9orf55)", "tax_id": 10090, "disease": "", "pathway": " (mmu:329877); (R-MMU-8876198)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;17242355;19131326;21183079;21454697;21750661;30779550;31219806;32502341;34428180;35820727", "class_list": "", "function": "Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin., [UniProtKB, PubMed]; Insulin-stimulated GLUT4 protein translocation in adipocytes requires the Rab10 guanine nucleotide exchange factor Dennd4C, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 25, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "A2AJX5;Q3U2K9", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030659 cytoplasmic vesicle membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0032483 regulation of Rab protein signal transduction;GO:0015031 protein transport;GO:0032869 cellular response to insulin stimulus;GO:0072659 protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "A6H8H2-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BWT5-1", "uniprot_id": [ { "id": "DIP2A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BWT5", "type": "external" } ], "mass": 165255.0, "length": 1523, "protein_name": "Disco-interacting protein 2 homolog A", "gene_name": "Dip2a", "organism": "Mouse", "refseq_name": "disco-interacting protein 2 homolog A", "refseq_ac": [ { "id": "NP_001074888", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074888", "type": "external" } ], "gene_names_uniprotkb": "Dip2a; Dip2; Kiaa0184", "gene_names_refseq": "4931420H10Rik; Dip2a; Dip2; Kiaa0184-hp; mKIAA0184", "protein_names_uniprotkb": "Disco-interacting protein 2 homolog A; 6.2.1.1; DIP2 homolog A", "protein_names_refseq": "DIP2 disco-interacting protein 2 homolog A; DIP2 homolog A; disco-interacting protein 2 homolog A", "tax_id": 10090, "disease": "", "pathway": " (mmu:64451)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;12137943;20054002;21183079;21750661;25428506;26605542;27802388;30084848;30672040;30779550;31600191;34562157;36227200;40021952", "class_list": "", "function": "A pilot study to investigate the alteration of gut microbial profile in Dip2a knockout mice., [RefSeq, PubMed]; Catalyzes the de novo synthesis of acetyl-CoA in vitro (PubMed:30672040). Promotes acetylation of CTTN, possibly by providing the acetyl donor, ensuring correct dendritic spine morphology and synaptic transmission (PubMed:31600191). Binds to follistatin-related protein FSTL1 and may act as a cell surface receptor for FSTL1, contributing to AKT activation and subsequent FSTL1-induced survival and function of endothelial cells and cardiac myocytes (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Dysregulation of AMPK-mTOR signaling leads to comorbid anxiety in Dip2a KO mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E0CXM7;Q8CHI0", "ec_number_list": [ { "id": "6.2.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.1", "type": "external" }, { "id": "6.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.17", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0003987 acetate-CoA ligase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0010629 negative regulation of gene expression;GO:0006085 acetyl-CoA biosynthetic process;GO:0060997 dendritic spine morphogenesis;GO:2000758 positive regulation of peptidyl-lysine acetylation;GO:1905274 regulation of modification of postsynaptic actin cytoskeleton", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q8BWT5-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51660-1", "uniprot_id": [ { "id": "DHB4_MOUSE", "url": "https://www.uniprot.org/uniprot/P51660", "type": "external" } ], "mass": 79482.0, "length": 735, "protein_name": "Peroxisomal multifunctional enzyme type 2", "gene_name": "Hsd17b4", "organism": "Mouse", "refseq_name": "peroxisomal multifunctional enzyme type 2", "refseq_ac": [ { "id": "NP_032318", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032318", "type": "external" } ], "gene_names_uniprotkb": "Hsd17b4; Edh17b4", "gene_names_refseq": "17-beta-HSD; 17[b]-HSD; DBP; Hsd17b4; MFE-2; MFP2; MPF-2; Mfp-2; perMFE-2", "protein_names_uniprotkb": "Peroxisomal multifunctional enzyme type 2; 17-beta-HSD 4; 17-beta-hydroxysteroid dehydrogenase 4; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase; D-bifunctional protein; DBP; MFE-2; MFP-2; Multifunctional protein 2", "protein_names_refseq": "17-beta-HSD 4; 17-beta-hydroxysteroid dehydrogenase 4; D-bifunctional protein; multifunctional protein 2; peroxisomal multifunctional enzyme type 2", "tax_id": 10090, "disease": "Perrault syndrome (Disease Ontology:DOID:0050857); D-bifunctional protein deficiency (Disease Ontology:DOID:0090031); hypertension (Disease Ontology:DOID:10763); Stiff-Person syndrome (Disease Ontology:DOID:13366); lipid metabolism disorder (Disease Ontology:DOID:3146); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:15488); (R-MMU-193368); (R-MMU-2046106); (R-MMU-389887); (R-MMU-390247); (R-MMU-9033241)", "pathway_count": 6, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;17242355;17442273;23576753;23806337;26740625;31219806;34428180;37453647;37507081;8547180", "class_list": "", "function": "Bifunctional enzyme acting on the peroxisomal fatty acid beta-oxidation pathway (PubMed:17442273). Catalyzes two of the four reactions in fatty acid degradation: hydration of 2-enoyl-CoA (trans-2-enoyl-CoA) to produce (3R)-3-hydroxyacyl-CoA, and dehydrogenation of (3R)-3-hydroxyacyl-CoA to produce 3-ketoacyl-CoA (3-oxoacyl-CoA), which is further metabolized by SCPx. Can use straight-chain and branched-chain fatty acids, as well as bile acid intermediates as substrates (By similarity) (PubMed:17442273). May play a role in peroxisomal beta-oxidation step in polyunsaturated fatty acids (PUFAs) biosynthesis. Possibly regulates systemic levels of docosahexaenoic acid (DHA, C22:6n-3) through a process involving endoplasmic reticulum desaturation and elongation of alpha-linolenic acid (ALA, C18:3n-3) to form tetracosahexaenoic acid (THA, C24:6n-3), which is then beta-oxidized to DHA in peroxisomes., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9DBM3", "ec_number_list": [ { "id": "4.2.1.134", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.134", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.n12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.n12", "type": "external" }, { "id": "4.2.1.107", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.107", "type": "external" }, { "id": "4.2.1.119", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.119", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity;GO:0004300 enoyl-CoA hydratase activity;GO:0016853 isomerase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005782 peroxisomal matrix", "go_biological_process": "GO:0008210 estrogen metabolic process;GO:0000038 very long-chain fatty acid metabolic process;GO:0006635 fatty acid beta-oxidation;GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase;GO:0006633 fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P51660-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P9P8-1", "uniprot_id": [ { "id": "DEN2C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P9P8", "type": "external" } ], "mass": 103937.0, "length": 914, "protein_name": "DENN domain-containing protein 2C", "gene_name": "Dennd2c", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Dennd2c", "gene_names_refseq": "", "protein_names_uniprotkb": "DENN domain-containing protein 2C", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-8876198)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21183079;21750661", "class_list": "", "function": "Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T9X2;Q3UV30;Q80V46", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6P9P8-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQM6-1", "uniprot_id": [ { "id": "DGCR8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EQM6", "type": "external" } ], "mass": 86321.0, "length": 773, "protein_name": "Microprocessor complex subunit DGCR8", "gene_name": "Dgcr8", "organism": "Mouse", "refseq_name": "microprocessor complex subunit DGCR8", "refseq_ac": [ { "id": "NP_201581", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_201581", "type": "external" } ], "gene_names_uniprotkb": "Dgcr8", "gene_names_refseq": "D16H22S1742E; D16H22S788E; D16Wis2; Dgcr8; Gy1; N41; Vo59c07; mir-1306", "protein_names_uniprotkb": "Microprocessor complex subunit DGCR8; DiGeorge syndrome critical region 8 homolog; Gy1", "protein_names_refseq": "DiGeorge syndrome critical region gene 8; diGeorge syndrome critical region 8 homolog; microprocessor complex subunit DGCR8", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); chromosome 22q11.2 deletion syndrome, distal (Disease Ontology:DOID:0060413)", "pathway": " (mmu:94223)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12705904;17259983;21183079;21750661;26255770;28528544;34428180;37542342;38110169", "class_list": "", "function": "Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis (PubMed:17259983). Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding. Specifically recognizes and binds N6-methyladenosine (m6A)-containing pri-miRNAs, a modification required for pri-miRNAs processing (By similarity). Involved in the silencing of embryonic stem cell self-renewal (PubMed:17259983). Also plays a role in DNA repair by promoting the recruitment of RNF168 to RNF8 and MDC1 at DNA double-strand breaks and subsequently the clearance of DNA breaks (By similarity)., [UniProtKB, PubMed, UniProtKB]; Dgcr8 functions in the secondary heart field for outflow tract and right ventricle development in mammals., [RefSeq, PubMed]; RNA-binding protein CCDC137 activates AKT signaling and promotes hepatocellular carcinoma through a novel non-canonical role of DGCR8 in mRNA localization. Erratum:[J Exp Clin Cancer Res. 2025 Dec 26;44(1):325. doi: 10.1186/s13046-025-03612-3. PMID: 41454394] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0003725 double-stranded RNA binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006974 DNA damage response;GO:0072091 regulation of stem cell proliferation;GO:0031053 primary miRNA processing;GO:2000633 positive regulation of pre-miRNA processing", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9EQM6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61188-1", "uniprot_id": [ { "id": "EZH2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61188", "type": "external" } ], "mass": 85292.0, "length": 746, "protein_name": "Histone-lysine N-methyltransferase EZH2", "gene_name": "Ezh2", "organism": "Mouse", "refseq_name": "histone-lysine N-methyltransferase EZH2 isoform 1", "refseq_ac": [ { "id": "NP_031997", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031997", "type": "external" } ], "gene_names_uniprotkb": "Ezh2; Enx1h", "gene_names_refseq": "Enx-1; Enx1h; Ezh2; KMT6; mKIAA4065", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase EZH2; 2.1.1.356; ENX-1; Enhancer of zeste homolog 2", "protein_names_refseq": "enhancer of zeste homolog 2; histone-lysine N-methyltransferase EZH2 isoform 1; histone-lysine N-methyltransferase EZH2", "tax_id": 10090, "disease": "diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745); colorectal adenoma (Disease Ontology:DOID:0050860); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); syndromic intellectual disability (Disease Ontology:DOID:0050888); myelodysplastic syndrome (Disease Ontology:DOID:0050908); chronic myelomonocytic leukemia (Disease Ontology:DOID:0080188); colorectal carcinoma (Disease Ontology:DOID:0080199); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); urinary bladder cancer (Disease Ontology:DOID:11054); leiomyoma (Disease Ontology:DOID:127); lung cancer (Disease Ontology:DOID:1324); Weaver syndrome (Disease Ontology:DOID:14731); pancreatic cancer (Disease Ontology:DOID:1793); colon cancer (Disease Ontology:DOID:219); endometriosis (Disease Ontology:DOID:289); invasive ductal carcinoma (Disease Ontology:DOID:3008); glioblastoma (Disease Ontology:DOID:3068); osteosarcoma (Disease Ontology:DOID:3347); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); cholangiocarcinoma (Disease Ontology:DOID:4947); myelofibrosis (Disease Ontology:DOID:4971); renal Wilms' tumor (Disease Ontology:DOID:5176); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); B-cell lymphoma (Disease Ontology:DOID:707); malignant pleural mesothelioma (Disease Ontology:DOID:7474); abdominal aortic aneurysm (Disease Ontology:DOID:7693); chronic myeloid leukemia (Disease Ontology:DOID:8552); acute megakaryocytic leukemia (Disease Ontology:DOID:8761); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:14056); (R-MMU-212300); (R-MMU-2559580); (R-MMU-3214841); (R-MMU-8943724); (R-MMU-8953750); (R-MMU-9764725); (R-MMU-9909649)", "pathway_count": 8, "publication_count": 38, "publication_id_list": "10051331;11390661;12123576;12649488;12689588;14752160;15516932;15520282;15684044;16415857;16717091;17259173;17344414;17937919;18086877;18281287;19026780;19026781;20144788;21183079;21750661;23970558;24009519;24074865;29472543;29525407;30305391;31219806;31451685;31704972;31914400;32461334;32873321;34230470;34428180;39627609;8861097;9742080", "class_list": "", "function": "Catalytic subunit of the PRC2/EED-EZH2 complex, a Polycomb group (PcG) complex that methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene (PubMed:12689588, PubMed:15516932, PubMed:15520282, PubMed:16717091, PubMed:19026780, PubMed:31914400). Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively (PubMed:16717091, PubMed:18086877). Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2 (By similarity). Compared to EZH1-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation (By similarity). The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity). Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes (PubMed:18086877). EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA (By similarity). Regulates the circadian clock via histone methylation at the promoter of the circadian genes (PubMed:16717091). Essential for the CRY1/2-mediated repression of the transcriptional activation of PER1/2 by the CLOCK-BMAL1 heterodimer; involved in the di and trimethylation of 'Lys-27' of histone H3 on PER1/2 promoters which is necessary for the CRY1/2 proteins to inhibit transcription (PubMed:16717091)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 38, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q99L74;Q9R090", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "1.14.11.68", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.68", "type": "external" }, { "id": "2.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.37", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "2.1.1.367", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.367", "type": "external" }, { "id": "2.1.1.356", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.356", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0043021 ribonucleoprotein complex binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0045202 synapse;GO:0000785 chromatin;GO:0005694 chromosome", "go_biological_process": "GO:0045605 negative regulation of epidermal cell differentiation;GO:0031509 subtelomeric heterochromatin formation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 4.1, "record_id": "Q61188-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZL0-1", "uniprot_id": [ { "id": "RIPK3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QZL0", "type": "external" } ], "mass": 53322.0, "length": 486, "protein_name": "Receptor-interacting serine/threonine-protein kinase 3", "gene_name": "Ripk3", "organism": "Mouse", "refseq_name": "receptor-interacting serine/threonine-protein kinase 3 isoform 1", "refseq_ac": [ { "id": "NP_064339", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064339", "type": "external" } ], "gene_names_uniprotkb": "Ripk3; Rip3", "gene_names_refseq": "2610528K09Rik; Rip3; Ripk3", "protein_names_uniprotkb": "Receptor-interacting serine/threonine-protein kinase 3; 2.7.11.1; RIP-3; RIP-like protein kinase 3; Receptor-interacting protein 3; mRIP3", "protein_names_refseq": "RIP-3; RIP-like protein kinase 3; mRIP3; receptor interacting protein 3; receptor-interacting serine/threonine-protein kinase 3 isoform 1; receptor-interacting serine/threonine-protein kinase 3", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); adult respiratory distress syndrome (Disease Ontology:DOID:11394)", "pathway": " (mmu:56532); (R-MMU-2562578); (R-MMU-3295583); (R-MMU-5213460); (R-MMU-5675482); (R-MMU-937041)", "pathway_count": 6, "publication_count": 41, "publication_id_list": "10490590;14749364;18442983;19144319;19590578;21750661;22265413;22423968;22645316;23612963;24012422;24019532;24095729;24129315;24557836;24813849;24813850;25428506;26495903;27321907;27746097;27819681;27819682;27917412;28011936;28607035;28842570;29883609;30635240;31519887;31599954;31600504;31645676;32184955;32200799;32296175;32782141;32855420;33870135;34399822;34471287", "class_list": "", "function": "RIP3 is not an essential modulator of NF-kappa B signaling downstream of several receptor systems, [RefSeq, PubMed]; Serine/threonine-protein kinase that activates necroptosis and apoptosis, two parallel forms of cell death (PubMed:27321907, PubMed:27746097, PubMed:27917412, PubMed:28607035, PubMed:32200799, PubMed:32296175). Necroptosis, a programmed cell death process in response to death-inducing TNF family members, is triggered by RIPK3 following activation by ZBP1 (PubMed:19590578, PubMed:22423968, PubMed:24012422, PubMed:24019532, PubMed:24095729, PubMed:24557836, PubMed:27321907, PubMed:27746097, PubMed:27819681, PubMed:27819682, PubMed:32200799, PubMed:32296175). Activated RIPK3 forms a necrosis-inducing complex and mediates phosphorylation of MLKL, promoting MLKL localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage (PubMed:24813849, PubMed:24813850, PubMed:27321907). In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following ZBP1 activation, which senses double-stranded Z-RNA structures, nuclear RIPK3 catalyzes phosphorylation and activation of MLKL, promoting disruption of the nuclear envelope and leakage of cellular DNA into the cytosol (PubMed:32200799, PubMed:32296175). Also regulates apoptosis: apoptosis depends on RIPK1, FADD and CASP8, and is independent of MLKL and RIPK3 kinase activity (PubMed:27321907). Phosphorylates RIPK1: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation (By similarity). In some cell types, also able to restrict viral replication by promoting cell death-independent responses (PubMed:30635240). In response to flavivirus infection in neurons, promotes a cell death-independent pathway that restricts viral replication: together with ZBP1, promotes a death-independent transcriptional program that modifies the cellular metabolism via up-regulation expression of the enzyme ACOD1/IRG1 and production of the metabolite itaconate (PubMed:30635240). Itaconate inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (PubMed:30635240). RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL (By similarity). These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 16, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "G3X8V8;Q3U3Z9;Q8K2Y2", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "3.4.22.61", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.61", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.4.1.255", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.255", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0097342 ripoptosome;GO:0032991 protein-containing complex", "go_biological_process": "GO:0001914 regulation of T cell mediated cytotoxicity;GO:0007165 signal transduction;GO:0051353 positive regulation of oxidoreductase activity;GO:0051607 defense response to virus;GO:1990000 amyloid fibril formation", "synthesized_glycan_count": 0, "hit_score": 4.7, "record_id": "Q9QZL0-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02650-1", "uniprot_id": [ { "id": "PAX5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q02650", "type": "external" } ], "mass": 42231.0, "length": 391, "protein_name": "Paired box protein Pax-5", "gene_name": "Pax5", "organism": "Mouse", "refseq_name": "paired box protein Pax-5", "refseq_ac": [ { "id": "NP_032808", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032808", "type": "external" } ], "gene_names_uniprotkb": "Pax5; Pax-5", "gene_names_refseq": "BSAP; EBB-1; KLP; Pax-5; Pax5", "protein_names_uniprotkb": "Paired box protein Pax-5; B-cell-specific transcription factor; BSAP", "protein_names_refseq": "B-cell-specific transcription factor; paired box gene 5; paired box protein Pax-5", "tax_id": 10090, "disease": "acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:18507); (R-MMU-8939245)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11799127;1516825;16546096;1685142;21750661;31219806;9042861", "class_list": "", "function": "Transcription factor that plays an essential role in commitment of lymphoid progenitors to the B-lymphocyte lineage (PubMed:9042861). Fulfills a dual role by repressing B-lineage inappropriate genes and simultaneously activating B-lineage-specific genes (PubMed:16546096). In turn, regulates cell adhesion and migration, induces V(H)-to-D(H)J(H) recombination, facilitates pre-B-cell receptor signaling and promotes development to the mature B-cell stage (PubMed:16546096, PubMed:9042861). Repression of the cohesin-release factor WAPL causes global changes of the chromosomal architecture in pro-B cells to facilitate the generation of a diverse antibody repertoire (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q02650-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RJI5-1", "uniprot_id": [ { "id": "BRSK1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5RJI5", "type": "external" } ], "mass": 85155.0, "length": 778, "protein_name": "Serine/threonine-protein kinase BRSK1", "gene_name": "Brsk1", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase BRSK1 isoform 1", "refseq_ac": [ { "id": "NP_001003920", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003920", "type": "external" } ], "gene_names_uniprotkb": "Brsk1; Gm1100; Sadb", "gene_names_refseq": "Brsk1; Gm1100; SAD-B; SADB", "protein_names_uniprotkb": "Serine/threonine-protein kinase BRSK1; 2.7.11.1; 2.7.11.26; BR serine/threonine-protein kinase 1; Brain-specific serine/threonine-protein kinase 1; Serine/threonine-protein kinase SAD-B", "protein_names_refseq": "BR serine/threonine-protein kinase 1; brain-specific serine/threonine-protein kinase 1; serine/threonine kinase SAD-B; serine/threonine kinase SADB; serine/threonine-protein kinase BRSK1 isoform 1; serine/threonine-protein kinase BRSK1; serine/threonine-protein kinase SAD-B", "tax_id": 10090, "disease": "depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (mmu:381979)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15705853;17482548;19648910;20026642;21183079;21750661;24129315;27626661;30307479;38497285", "class_list": "", "function": "Brain-specific serine/threonine-protein kinase 1 is a substrate of protein kinase C epsilon involved in sex-specific ethanol and anxiety phenotypes., [RefSeq, PubMed]; CAST/SAD-B reaction serves as a brake on synaptic transmission, [RefSeq, PubMed]; Isozyme-Specific Role of SAD-A in Neuronal Migration During Development of Cerebral Cortex., [RefSeq, PubMed]; Once activated, LKB1 phosphorylates and thereby activates SAD-A and SAD-B kinases, which are also required for neuronal polarization in the cerebral cortex., [RefSeq, PubMed]; Results show that SAD-A and SAD-B, mammalian orthologs of a kinase needed for presynaptic differentiation in Caenorhabditis elegans, are required for neuronal polarization., [RefSeq, PubMed]; Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-504' and 'Ser-554'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A7LH90;A7LH91;B7SRN7;Q699J6", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0050321 tau-protein kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0014069 postsynaptic density", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0099504 synaptic vesicle cycle;GO:0006468 protein phosphorylation;GO:0007409 axonogenesis;GO:0008306 associative learning", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q5RJI5-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03173-1", "uniprot_id": [ { "id": "ENAH_MOUSE", "url": "https://www.uniprot.org/uniprot/Q03173", "type": "external" } ], "mass": 85844.0, "length": 802, "protein_name": "Protein enabled homolog", "gene_name": "Enah", "organism": "Mouse", "refseq_name": "protein enabled homolog isoform 4", "refseq_ac": [ { "id": "NP_001076590", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076590", "type": "external" } ], "gene_names_uniprotkb": "Enah; Mena; Ndpp1", "gene_names_refseq": "Enah; Mena; NDPP-1; Ndpp1; WBP8", "protein_names_uniprotkb": "Protein enabled homolog; NDPP-1; NPC-derived proline-rich protein 1", "protein_names_refseq": "NPC derived proline rich protein 1; protein enabled homolog isoform 4; protein enabled homolog", "tax_id": 10090, "disease": "stomach cancer (Disease Ontology:DOID:10534); tauopathy (Disease Ontology:DOID:680); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:13800); (R-MMU-376176)", "pathway_count": 2, "publication_count": 28, "publication_id_list": "10069337;10338211;12134088;12672821;12941633;1420303;14506234;15066263;15148305;15345747;15642358;21183079;21750661;22517741;22645316;24332715;30016717;30899004;32848054;34678516;36542983;36852467;37027295;40021952;40885482;8861907;9171351;9407065", "class_list": "", "function": "DJ-1 promotes cell migration by interacting with Mena, the mammalian homolog of Drosophila enabled., [RefSeq, PubMed]; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Matrix stiffness regulates tumor cell intravasation through expression and ESRP1-mediated alternative splicing of MENA., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 2, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 9, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 9, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 9, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "P70430;P70431;P70432;P70433;Q5D053", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0017124 SH3 domain binding;GO:0050699 WW domain binding;GO:0005522 profilin binding", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0070358 actin polymerization-dependent cell motility;GO:0007015 actin filament organization;GO:0030036 actin cytoskeleton organization;GO:1990830 cellular response to leukemia inhibitory factor;GO:0008154 actin polymerization or depolymerization", "synthesized_glycan_count": 0, "hit_score": 4.1, "record_id": "Q03173-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P45481-1", "uniprot_id": [ { "id": "CBP_MOUSE", "url": "https://www.uniprot.org/uniprot/P45481", "type": "external" } ], "mass": 265494.0, "length": 2441, "protein_name": "Histone lysine acetyltransferase CREBBP", "gene_name": "Crebbp", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Crebbp; Cbp", "gene_names_refseq": "", "protein_names_uniprotkb": "Histone lysine acetyltransferase CREBBP; 2.3.1.-; 2.3.1.48; Protein lactyltransferas CREBBP; Protein-lysine acetyltransferase CREBBP", "protein_names_refseq": "", "tax_id": 10090, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); autism spectrum disorder (Disease Ontology:DOID:0060041); pre-eclampsia (Disease Ontology:DOID:10591); Huntington's disease (Disease Ontology:DOID:12858); alcohol use disorder (Disease Ontology:DOID:1574); Rubinstein-Taybi syndrome (Disease Ontology:DOID:1933); acute myeloid leukemia (Disease Ontology:DOID:9119); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:12914); (R-MMU-1234158); (R-MMU-201722); (R-MMU-2122947); (R-MMU-3134973); (R-MMU-3371568); (R-MMU-350054); (R-MMU-400206); (R-MMU-5621575); (R-MMU-8866907); (R-MMU-8939246); (R-MMU-8941856); (R-MMU-9018519); (R-MMU-933541); (R-MMU-9617629); (R-MMU-9707564); (R-MMU-9759194); (R-MMU-9856649)", "pathway_count": 18, "publication_count": 31, "publication_id_list": "10207073;10215616;10722728;11115394;11701890;11943779;12504852;12527917;14594809;15220471;16287980;17226766;18160706;21183079;21750661;22645316;23443134;23806337;24737000;28552616;32782141;34428180;34678516;36210013;36852467;40885482;40997131;8413673;8552098;8616895;9192892", "class_list": "", "function": "Acetylates histones, giving a specific tag for transcriptional activation (PubMed:11115394). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (By similarity). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10207073, PubMed:11701890, PubMed:15220471, PubMed:16287980). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes (By similarity). Acts as a coactivator of ALX1 (By similarity). Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers (By similarity). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24737000). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (By similarity). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (By similarity). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (By similarity). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as lactoyl-CoA, and is able to mediate protein lactylation (By similarity). Catalyzes lactylation of MRE11 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (By similarity). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 9, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 9, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 9, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "E9QPH4", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "1.14.11.68", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.68", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "1.14.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" }, { "id": "3.9.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.-", "type": "external" }, { "id": "6.2.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.1", "type": "external" }, { "id": "6.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.17", "type": "external" }, { "id": "2.1.1.356", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.356", "type": "external" }, { "id": "2.3.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.1.199", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.199", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.3.1.286", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.286", "type": "external" }, { "id": "2.3.1.259", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.259", "type": "external" }, { "id": "2.3.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.20", "type": "external" }, { "id": "2.3.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.76", "type": "external" }, { "id": "2.3.1.57", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.57", "type": "external" }, { "id": "2.3.1.80", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.80", "type": "external" }, { "id": "4.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.-", "type": "external" }, { "id": "2.1.1.319", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.319", "type": "external" } ], "go_molecular_function": "GO:0001093 TFIIB-class transcription factor binding;GO:0061733 protein-lysine-acetyltransferase activity;GO:0060090 molecular adaptor activity;GO:0003677 DNA binding;GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016604 nuclear body;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0060355 positive regulation of cell adhesion molecule production;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 4.2, "record_id": "P45481-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O55028-1", "uniprot_id": [ { "id": "BCKD_MOUSE", "url": "https://www.uniprot.org/uniprot/O55028", "type": "external" } ], "mass": 46588.0, "length": 412, "protein_name": "Branched-chain alpha-ketoacid dehydrogenase kinase", "gene_name": "Bckdk", "organism": "Mouse", "refseq_name": "branched-chain alpha-ketoacid dehydrogenase kinase precursor", "refseq_ac": [ { "id": "NP_033869", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033869", "type": "external" } ], "gene_names_uniprotkb": "Bckdk", "gene_names_refseq": "BDK; Bckdk", "protein_names_uniprotkb": "Branched-chain alpha-ketoacid dehydrogenase kinase; 2.7.11.1; 2.7.11.4; BCKDH kinase; BCKDHKIN; BDK; [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial", "protein_names_refseq": "BCKD-kinase; BCKDH kinase; BCKDHKIN; [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial; branched-chain alpha-ketoacid dehydrogenase kinase precursor; branched-chain alpha-ketoacid dehydrogenase kinase", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); branched-chain keto acid dehydrogenase kinase deficiency (Disease Ontology:DOID:0090126); oligospermia (Disease Ontology:DOID:14228)", "pathway": " (mmu:12041); (R-MMU-70895)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "15302860;16452087;16875466;17208939;19144319;21183079;21750661;22956686;23576753;29237092;31219806;33300544;33773101;39389936;9611264", "class_list": "", "function": "BCKDH kinase promotes hepatic gluconeogenesis independent of BCKDHA. Publication Status: Online-Only, [RefSeq, PubMed]; BCKDK regulates the TCA cycle through PDC in the absence of PDK family during embryonic development., [RefSeq, PubMed]; Branched-chain a-keto acid dehydrogenase complex kinase plays an important role in conserving branched-chain amino acids by limiting their oxidation, [RefSeq, PubMed]; Serine/threonine-protein kinase component of macronutrients metabolism. Forms a functional kinase and phosphatase pair with PPM1K, serving as a metabolic regulatory node that coordinates branched-chain amino acids (BCAAs) with glucose and lipid metabolism via two distinct phosphoprotein targets: mitochondrial BCKDHA subunit of the branched-chain alpha-ketoacid dehydrogenase (BCKDH) complex and cytosolic ACLY, a lipogenic enzyme of Krebs cycle (By similarity). Phosphorylates and inactivates mitochondrial BCKDH complex a multisubunit complex consisting of three multimeric components each involved in different steps of BCAA catabolism: E1 composed of BCKDHA and BCKDHB, E2 core composed of DBT monomers, and E3 composed of DLD monomers. Associates with the E2 component of BCKDH complex and phosphorylates BCKDHA on Ser-334, leading to conformational changes that interrupt substrate channeling between E1 and E2 and inactivates the BCKDH complex (By similarity). Phosphorylates ACLY on Ser-455 in response to changes in cellular carbohydrate abundance such as occurs during fasting to feeding metabolic transition. Refeeding stimulates MLXIPL/ChREBP transcription factor, leading to increased BCKDK to PPM1K expression ratio, phosphorylation and activation of ACLY that ultimately results in the generation of malonyl-CoA and oxaloacetate immediate substrates of de novo lipogenesis and glucogenesis, respectively (By similarity). Recognizes phosphosites having SxxE/D canonical motif (By similarity)., [UniProtKB, UniProtKB]; Tissue-specific translation of murine BCKDK mRNA is dependent upon an upstream open reading frame in the 5'-untranslated region, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "1.2.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.4", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0045252 oxoglutarate dehydrogenase complex", "go_biological_process": "GO:0007283 spermatogenesis;GO:0008610 lipid biosynthetic process;GO:0010906 regulation of glucose metabolic process;GO:0009083 branched-chain amino acid catabolic process;GO:0006574 L-valine catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "O55028-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47934-1", "uniprot_id": [ { "id": "CACP_MOUSE", "url": "https://www.uniprot.org/uniprot/P47934", "type": "external" } ], "mass": 70840.0, "length": 626, "protein_name": "Carnitine O-acetyltransferase", "gene_name": "Crat", "organism": "Mouse", "refseq_name": "carnitine O-acetyltransferase isoform a", "refseq_ac": [ { "id": "NP_031786", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031786", "type": "external" } ], "gene_names_uniprotkb": "Crat", "gene_names_refseq": "CARAT; Crat", "protein_names_uniprotkb": "Carnitine O-acetyltransferase; 2.3.1.137; 2.3.1.7; CAT; Carnitine acetylase; Carnitine acetyltransferase; CrAT", "protein_names_refseq": "CAT; carnitine O-acetyltransferase isoform a; carnitine O-acetyltransferase; carnitine acetylase", "tax_id": 10090, "disease": "neurodegeneration with brain iron accumulation (Disease Ontology:DOID:0110734)", "pathway": " (mmu:12908); (R-MMU-389887); (R-MMU-70895); (R-MMU-9033241)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "12526798;14711372;15155726;21750661;23806337;34428180;36058299;36288343;37443356;37507081;39927985;9065756", "class_list": "", "function": "CRAT links cholesterol metabolism to innate immune responses in the heart., [RefSeq, PubMed]; Catalyzes the reversible transfer of acyl groups from carnitine to coenzyme A (CoA) and regulates the acyl-CoA/CoA ratio. Also plays a crucial role in the transport of fatty acids for beta-oxidation. Responsible for the synthesis of short- and branched-chain acylcarnitines. Active towards some branched-chain amino acid oxidation pathway (BCAAO) intermediates. Trans-2-enoyl-CoAs and 2-methylacyl-CoAs are poor substrates., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Structural model for L-CPT I (liver CPT I), based on the similarity of this enzyme to the recently crystallized mouse carnitine acetyltransferase, [RefSeq, PubMed]; The Regulators of Peroxisomal Acyl-Carnitine Shuttle CROT and CRAT Promote Metastasis in Melanoma., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TCG3;Q3V1Y3;Q923A6", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.1.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4", "type": "external" }, { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "2.3.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.21", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "1.5.3.13", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.13", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "1.4.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1", "type": "external" }, { "id": "4.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.9", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "1.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.1", "type": "external" }, { "id": "1.5.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.7", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "1.2.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" } ], "go_molecular_function": "GO:0003997 acyl-CoA oxidase activity;GO:0008458 carnitine O-octanoyltransferase activity;GO:0004092 carnitine O-acetyltransferase activity;GO:0016746 acyltransferase activity;GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005777 peroxisome;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase;GO:0046459 short-chain fatty acid metabolic process;GO:0051791 medium-chain fatty acid metabolic process;GO:0019254 carnitine metabolic process, CoA-linked", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P47934-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q52KB6-1", "uniprot_id": [ { "id": "C2CD3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q52KB6", "type": "external" } ], "mass": 255346.0, "length": 2323, "protein_name": "C2 domain-containing protein 3", "gene_name": "C2cd3", "organism": "Mouse", "refseq_name": "C2 domain-containing protein 3", "refseq_ac": [ { "id": "NP_001017985", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017985", "type": "external" } ], "gene_names_uniprotkb": "C2cd3; Hty", "gene_names_refseq": "C2cd3", "protein_names_uniprotkb": "C2 domain-containing protein 3; Protein hearty", "protein_names_refseq": "C2 domain-containing protein 3; protein hearty", "tax_id": 10090, "disease": "orofaciodigital syndrome XIV (Disease Ontology:DOID:0060958)", "pathway": " (mmu:277939); (R-MMU-5620912)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "19004860;21183079;21750661;21952136;24469809;24997988;25428506;25605945;30084848;30779550;31219806;34428180;36852467;38810379", "class_list": "", "function": "Component of the centrioles that acts as a positive regulator of centriole elongation (PubMed:24997988). Promotes assembly of centriolar distal appendage, a structure at the distal end of the mother centriole that acts as an anchor of the cilium, and is required for recruitment of centriolar distal appendages proteins CEP83, SCLT1, CEP89, FBF1 and CEP164. Not required for centriolar satellite integrity or RAB8 activation (PubMed:24469809). Required for primary cilium formation. Required for sonic hedgehog/SHH signaling and for proteolytic processing of GLI3 (PubMed:19004860)., [UniProtKB, PubMed, PubMed, PubMed]; Component of the centrioles that acts as a positive regulator of centriole elongation. Promotes assembly of centriolar distal appendage, a structure at the distal end of the mother centriole that acts as an anchor of the cilium, and is required for recruitment of centriolar distal appendages proteins CEP83, SCLT1, CEP89, FBF1 and CEP164. Not required for centriolar satellite integrity or RAB8 activation. Required for primary cilium formation. Required for sonic hedgehog/SHH signaling and for proteolytic processing of GLI3., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Furthering a link between Hedgehog signaling and cilia function, we find that cilia formation and proteolytic processing of Gli3 are disrupted in C2cd3 mutants., [RefSeq, PubMed]; Results suggest that C2cd3 regulates cilium biogenesis by promoting the assembly of centriolar distal appendages critical for docking ciliary vesicles and recruiting other essential ciliogenic proteins, [RefSeq, PubMed]; The ciliary protein C2cd3 is required for mandibular musculoskeletal tissue patterning., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9QL99;Q3UFQ3;Q80V48;Q8BXE5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0005815 microtubule organizing center;GO:0005814 centriole;GO:0034451 centriolar satellite;GO:0036064 ciliary basal body", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0016485 protein processing;GO:0007420 brain development;GO:0030326 embryonic limb morphogenesis;GO:0021915 neural tube development", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q52KB6-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80YA3-1", "uniprot_id": [ { "id": "DDHD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80YA3", "type": "external" } ], "mass": 61823.0, "length": 547, "protein_name": "Phospholipase DDHD1", "gene_name": "Ddhd1", "organism": "Mouse", "refseq_name": "phospholipase DDHD1 isoform 1", "refseq_ac": [ { "id": "NP_001034195", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034195", "type": "external" } ], "gene_names_uniprotkb": "Ddhd1", "gene_names_refseq": "Ddhd1; Mir5131; PA-PLA1", "protein_names_uniprotkb": "Phospholipase DDHD1; 3.1.1.111; 3.1.1.118; 3.1.1.32; DDHD domain-containing protein 1; PA-PLA1; Phosphatidic acid-preferring phospholipase A1 homolog; Phospholipid sn-1 acylhydrolase", "protein_names_refseq": "DDHD domain-containing protein 1; phosphatidic acid-preferring phospholipase A1 homolog; phospholipase DDHD1 isoform 1; phospholipase DDHD1; phospholipid sn-1 acylhydrolase", "tax_id": 10090, "disease": "hereditary spastic paraplegia 28 (Disease Ontology:DOID:0110779); hereditary spastic paraplegia 54 (Disease Ontology:DOID:0110806)", "pathway": " (mmu:114874); (R-MMU-1483166)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "21183079;21750661;24599962;30221923;31219806;34203471;34428180;37189713;37832604;40021952;40885482", "class_list": "", "function": "A possible mechanism of PA regulation of the mitochondrial membrane and demonstrate an in vivo function of PA-PLA1 in the organization of mitochondria during spermiogenesis., [RefSeq, PubMed]; DDHD1 is a principal regulator of bioactive lysophosphatidylinositol lipids and other lysophospholipids, as well as phosphatidylinositol phosphates, in the mammalian nervous system, pointing to a potential role for these lipid pathways in hereditary spastic paraplegia, [RefSeq, PubMed]; Phospholipase A1 (PLA1) that hydrolyzes ester bonds at the sn-1 position of glycerophospholipids producing a free fatty acid and a lysophospholipid (Probable) (PubMed:30221923). Prefers phosphatidate (1,2-diacyl-sn-glycero-3-phosphate, PA) as substrate in vitro, but can efficiently hydrolyze phosphatidylinositol (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol), PI), as well as a range of other glycerophospholipid substrates such as phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE), phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) and phosphatidylglycerol (1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol), PG) (Probable) (PubMed:30221923). Involved in the regulation of the endogenous content of polyunsaturated PI and PS lipids in the nervous system (PubMed:30221923). Changes in these lipids extend to downstream metabolic products like PI phosphates PIP and PIP2, which play fundamental roles in cell biology (PubMed:30221923). Regulates mitochondrial morphology (PubMed:24599962). These dynamic changes may be due to PA hydrolysis at the mitochondrial surface (PubMed:24599962). May play a regulatory role in spermatogenesis or sperm function (PubMed:24599962)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8VEF2", "ec_number_list": [ { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.34", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.111", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.111", "type": "external" }, { "id": "3.1.1.118", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.118", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004620 phospholipase activity;GO:0008970 phospholipase A1 activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0030382 sperm mitochondrion organization;GO:0046488 phosphatidylinositol metabolic process;GO:0090141 positive regulation of mitochondrial fission", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q80YA3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70318-1", "uniprot_id": [ { "id": "E41L2_MOUSE", "url": "https://www.uniprot.org/uniprot/O70318", "type": "external" } ], "mass": 109940.0, "length": 988, "protein_name": "Band 4.1-like protein 2", "gene_name": "Epb41l2", "organism": "Mouse", "refseq_name": "band 4.1-like protein 2 isoform 1", "refseq_ac": [ { "id": "NP_001186194", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186194", "type": "external" } ], "gene_names_uniprotkb": "Epb41l2; Epb4.1l2", "gene_names_refseq": "4.1G; D10Ertd398e; Epb4.1l2; Epb41l2; NBL2", "protein_names_uniprotkb": "Band 4.1-like protein 2; 4.1G; Erythrocyte membrane protein band 4.1-like 2; Generally expressed protein 4.1", "protein_names_refseq": "band 4.1-like protein 2 isoform 1; band 4.1-like protein 2; erythrocyte membrane protein band 4.1-like 2 retinal; erythrocyte protein band 4.1 like 2; erythrocyte protein band 4.1l2 long; erythrocyte protein band 4.1l2 middle; generally expressed protein 4.1", "tax_id": 10090, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589)", "pathway": " (mmu:13822); (R-MMU-6794361)", "pathway_count": 2, "publication_count": 22, "publication_id_list": "15592455;17242355;19131326;19144319;21183079;21750661;22645316;25153642;26644476;28528544;28755316;31219806;32848054;34428180;34678516;34887587;35216233;36210013;37828378;39627609;40885482;9531554", "class_list": "", "function": "4.1G has a role in cell adhesion, spreading, and migration in MEF cells by modulating the surface expression of beta1 integrin and subsequent downstream signal transduction, [RefSeq, PubMed]; Cytoskeletal Protein 4.1G Is Essential for the Primary Ciliogenesis and Osteoblast Differentiation in Bone Formation. Publication Status: Online-Only, [RefSeq, PubMed]; Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase., [UniProtKB, UniProtKB]; The 4.1G functions as a signal for proper formation of myelin in peripheral nervous system., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "G3X9B8", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005198 structural molecule activity;GO:0030507 spectrin binding;GO:0042731 PH domain binding;GO:0008092 cytoskeletal protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0051301 cell division;GO:0030036 actin cytoskeleton organization;GO:0031032 actomyosin structure organization;GO:0008360 regulation of cell shape;GO:0030866 cortical actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "O70318-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16283-1", "uniprot_id": [ { "id": "B3A3_MOUSE", "url": "https://www.uniprot.org/uniprot/P16283", "type": "external" } ], "mass": 135373.0, "length": 1227, "protein_name": "Anion exchange protein 3", "gene_name": "Slc4a3", "organism": "Mouse", "refseq_name": "anion exchange protein 3", "refseq_ac": [ { "id": "NP_033234", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033234", "type": "external" } ], "gene_names_uniprotkb": "Slc4a3; Ae3", "gene_names_refseq": "A930038D23Rik; Ae3; Slc4a3", "protein_names_uniprotkb": "Anion exchange protein 3; AE 3; Anion exchanger 3; Neuronal band 3-like protein; Solute carrier family 4 member 3", "protein_names_refseq": "AE 3; anion exchange protein 3; anion exchanger 3; neuronal band 3-like protein; solute carrier family 4 member 3", "tax_id": 10090, "disease": "short QT syndrome (Disease Ontology:DOID:0050793); anemia (Disease Ontology:DOID:2355)", "pathway": " (mmu:20536); (R-MMU-425381)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;12592704;17114649;21183079;21750661;24129315;25402438;25428506;2686841;27353306;28779178;8126106", "class_list": "", "function": "Ae3 is expressed in murine kidney at very low levels., [RefSeq, PubMed]; Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane. May be involved in the regulation of intracellular pH, and the modulation of cardiac action potential (By similarity)., [UniProtKB, PubMed, UniProtKB]; These findings suggest a new type of neuron-astrocyte communication, based on the expression of AE3 in neurons, which could explain how AE3 reduces seizure susceptibility, [RefSeq, PubMed]; These results support a model in which the AE3 Cl(-)/HCO3(-) exchanger, coupled with parallel Cl(-) and H(+)-extrusion mechanisms and extracellular carbonic anhydrase, is responsible for active transport-mediated disposal of CO2. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9ERP5", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0022857 transmembrane transporter activity;GO:0015106 bicarbonate transmembrane transporter activity;GO:0140900 chloride:bicarbonate antiporter activity;GO:0008509 monoatomic anion transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0061337 cardiac conduction;GO:0015701 bicarbonate transport;GO:0051453 regulation of intracellular pH;GO:0098901 regulation of cardiac muscle cell action potential", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P16283-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1000000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35613-1", "uniprot_id": [ { "id": "DAXX_MOUSE", "url": "https://www.uniprot.org/uniprot/O35613", "type": "external" } ], "mass": 81489.0, "length": 739, "protein_name": "Death domain-associated protein 6", "gene_name": "Daxx", "organism": "Mouse", "refseq_name": "death domain-associated protein 6", "refseq_ac": [ { "id": "NP_001186662", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186662", "type": "external" } ], "gene_names_uniprotkb": "Daxx", "gene_names_refseq": "Daxx", "protein_names_uniprotkb": "Death domain-associated protein 6; Daxx", "protein_names_refseq": "death domain-associated protein 6; death-domain associated protein", "tax_id": 10090, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); lung non-squamous non-small cell carcinoma (Disease Ontology:DOID:0080521); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); appendiceal neoplasm (Disease Ontology:DOID:11240); leukemia (Disease Ontology:DOID:1240); neuroendocrine tumor (Disease Ontology:DOID:169); pancreatic endocrine carcinoma (Disease Ontology:DOID:1798); islet cell tumor (Disease Ontology:DOID:1799); ovary epithelial cancer (Disease Ontology:DOID:2152); transient cerebral ischemia (Disease Ontology:DOID:224); colon adenocarcinoma (Disease Ontology:DOID:234); transitional cell carcinoma (Disease Ontology:DOID:2671); clear cell adenocarcinoma (Disease Ontology:DOID:4468)", "pathway": " (mmu:13163); (R-MMU-3899300); (R-MMU-6804757); (R-MMU-9670095)", "pathway_count": 4, "publication_count": 16, "publication_id_list": "10684855;11034606;11799127;12529400;16287980;20504901;20651253;21183079;21750661;22199361;22500635;34428180;37633949;37655670;37767699;9215629", "class_list": "", "function": "DAXX safeguards heterochromatin formation in embryonic stem cells., [RefSeq, PubMed]; Daxx knockdown promoted rDNA transcription without impairing H3.3 expression in mouse preimplantation embryos., [RefSeq, PubMed]; The histone chaperone function of Daxx is dispensable for embryonic development. Publication Status: Online-Only, [RefSeq, PubMed]; Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53 stabilization. Acts as a histone chaperone that facilitates deposition of histone H3.3. Acts as a targeting component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Does not affect the ATPase activity of ATRX but alleviates its transcription repression activity. Upon neuronal activation associates with regulatory elements of selected immediate early genes where it promotes deposition of histone H3.3 which may be linked to transcriptional induction of these genes. Required for the recruitment of histone H3.3:H4 dimers to PML-nuclear bodies (PML-NBs); the process is independent of ATRX and facilitated by ASF1A; PML-NBs are suggested to function as regulatory sites for the incorporation of newly synthesized histone H3.3 into chromatin. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. Plays a role as a positive regulator of the heat shock transcription factor HSF1 activity during the stress protein response (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9QWT8;Q9QWV3", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0019899 enzyme binding;GO:0019901 protein kinase binding;GO:0042803 protein homodimerization activity;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0005874 microtubule", "go_biological_process": "GO:0030578 PML body organization;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0008283 cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "O35613-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VBU8-1", "uniprot_id": [ { "id": "BANP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VBU8", "type": "external" } ], "mass": 59657.0, "length": 548, "protein_name": "Protein BANP", "gene_name": "Banp", "organism": "Mouse", "refseq_name": "protein BANP isoform 1", "refseq_ac": [ { "id": "NP_001103570", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103570", "type": "external" } ], "gene_names_uniprotkb": "Banp; Smar1", "gene_names_refseq": "Banp; SMAR1", "protein_names_uniprotkb": "Protein BANP; Btg3-associated nuclear protein; Scaffold/matrix-associated region-1-binding protein", "protein_names_refseq": "protein BANP isoform 1; protein BANP; scaffold/matrix-associated region-1-binding protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:53325); (R-MMU-6804759); (R-MMU-9766229)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "10940556;10950932;12494467;15371550;15623522;15701641;16166625;17229733;21750661;22978699;23806337;26080397;34428180;34450266;35980125;37817309", "class_list": "", "function": "A short SMAR1 peptide efficiently activates p53 protein by mediating its phosphorylation at serine 15, resulting in the activation of p21 and in effect regulating cell cycle checkpoint., [RefSeq, PubMed]; Chromatin remodeling protein SMAR1 regulates adipogenesis by modulating the expression of PPARgamma., [RefSeq, PubMed]; Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function (PubMed:10950932, PubMed:12494467, PubMed:15623522). Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer (PubMed:10950932, PubMed:15371550). Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels (PubMed:16166625). Promotes TP53 activation, which causes cell cycle arrest and inhibits tumor growth (PubMed:12494467, PubMed:17229733). Plays a role in the regulation of alternative splicing (By similarity). Binds to CD44 pre-mRNA and negatively regulates the inclusion of CD44 proximal variable exons v2-v6 but has no effect on distal variable exons v7-v10 (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Nuclear Matrix-associated Protein SMAR1 Attenuated Acute Graft-versus-host Disease by Targeting JAK-STAT Signaling in CD4 + T Cells., [RefSeq, PubMed]; SMAR1 inhibits proliferation, EMT and Warburg effect of bladder cancer cells by suppressing the activity of the Wnt/beta-catenin signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88973;Q3U4R5;Q91YZ1;Q9ES51", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0016604 nuclear body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8VBU8-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35887-1", "uniprot_id": [ { "id": "CALU_MOUSE", "url": "https://www.uniprot.org/uniprot/O35887", "type": "external" } ], "mass": 37064.0, "length": 315, "protein_name": "Calumenin", "gene_name": "Calu", "organism": "Mouse", "refseq_name": "calumenin isoform 1 precursor", "refseq_ac": [ { "id": "NP_031620", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031620", "type": "external" } ], "gene_names_uniprotkb": "Calu", "gene_names_refseq": "9530075H20Rik; Calu", "protein_names_uniprotkb": "Calumenin; Crocalbin", "protein_names_refseq": "calumenin isoform 1 precursor; crocalbin", "tax_id": 10090, "disease": "colorectal carcinoma (Disease Ontology:DOID:0080199); proliferative diabetic retinopathy (Disease Ontology:DOID:13207)", "pathway": " (mmu:12321); (R-MMU-381426); (R-MMU-8957275)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "19740751;21183079;21750661;22178608;23806337;24632605;30899004;34428180;37453647;37828378;39927985;40997131;9218460", "class_list": "", "function": "Extracellular calumenin regulates fibulin-1 to have crucial roles in ERK1/2 signaling and cell migration., [RefSeq, PubMed]; Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum. Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3. By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis. Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens. This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion., [UniProtKB, UniProtKB, UniProtKB]; Regions of 132-222 amino acids of calumenin and 853-892 amino acids of SERCA2 are the major binding partners., [RefSeq, PubMed]; This study points to a possible important role of calumenin in migration and differentiation of neurons, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004857 enzyme inhibitor activity;GO:0019899 enzyme binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "O35887-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WV69-1", "uniprot_id": [ { "id": "DEMA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WV69", "type": "external" } ], "mass": 45468.0, "length": 405, "protein_name": "Dematin", "gene_name": "Dmtn", "organism": "Mouse", "refseq_name": "dematin isoform 1", "refseq_ac": [ { "id": "NP_001239591", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239591", "type": "external" } ], "gene_names_uniprotkb": "Dmtn; Epb4.9; Epb49", "gene_names_refseq": "Dmtn; Epb4.9; Epb49; dematin", "protein_names_uniprotkb": "Dematin; Dematin actin-binding protein; Erythrocyte membrane protein band 4.9", "protein_names_refseq": "dematin isoform 1; erythrocyte membrane protein band 4.9; erythrocyte protein band 4.9", "tax_id": 10090, "disease": "", "pathway": " (mmu:13829); (R-MMU-5223345)", "pathway_count": 2, "publication_count": 26, "publication_id_list": "10.3389/fragi.2021.757801;10501976;11856323;12011427;15345747;16452087;17242355;18505823;19458039;21183079;21750661;22517741;22645316;23060452;25428506;28657654;30059200;32848054;34418053;34678516;35820727;35822049;36852467;37216480;40021952;40885482", "class_list": "", "function": "Dematin Regulates Calcium Mobilization, Thrombosis, and Early Akt Activation in Platelets., [RefSeq, PubMed]; Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Also plays a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 12, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 12, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 12, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "F8WIF9;Q3TYC5;Q8JZV5;Q9WVM2", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005102 signaling receptor binding;GO:0051015 actin filament binding;GO:0030507 spectrin binding", "go_cellular_component": "GO:0005790 smooth endoplasmic reticulum;GO:0005829 cytosol;GO:0005884 actin filament;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:0071786 endoplasmic reticulum tubular network organization;GO:0032956 regulation of actin cytoskeleton organization;GO:0051563 smooth endoplasmic reticulum calcium ion homeostasis;GO:0071320 cellular response to cAMP;GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 4.0, "record_id": "Q9WV69-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WUF3-1", "uniprot_id": [ { "id": "C8AP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WUF3", "type": "external" } ], "mass": 219091.0, "length": 1962, "protein_name": "CASP8-associated protein 2", "gene_name": "Casp8ap2", "organism": "Mouse", "refseq_name": "CASP8-associated protein 2", "refseq_ac": [ { "id": "NP_001116450", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116450", "type": "external" } ], "gene_names_uniprotkb": "Casp8ap2; Flash", "gene_names_refseq": "Casp8ap2; D4Ertd659e; FLASH", "protein_names_uniprotkb": "CASP8-associated protein 2; FLICE-associated huge protein", "protein_names_refseq": "CASP8-associated protein 2; FLICE-associated huge protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:26885); (R-MMU-3899300)", "pathway_count": 2, "publication_count": 21, "publication_id_list": "10235259;11340079;15592525;17003125;17245429;18299400;20173027;20484733;21750661;21952136;22872234;23806337;25428506;26208142;30084848;30779550;31219806;34203471;34428180;35820727;40021952", "class_list": "", "function": "Participates in TNF-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B (By similarity). Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation (By similarity). Involved in TNF-induced activation of NF-kappa-B via a TRAF2-dependent pathway (PubMed:11340079). Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B (PubMed:15592525). Required for the activation of CASP8 in FAS-mediated apoptosis (By similarity). Involved for histone gene transcription and progression through S phase: required for the generation of mature histone mRNAs following the 3' end cleavage of histone pre-mRNAs (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; The functional interaction of E2A and FLASH play an important role in cell proliferation and cellular senescence via regulation of p21 expression in experimental glomerulonephritis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B1AX74;Q9CSW2", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0042802 identical protein binding;GO:0003714 transcription corepressor activity;GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process;GO:0032184 SUMO polymer binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0016605 PML body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors;GO:0036337 Fas signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q9WUF3-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97326-1", "uniprot_id": [ { "id": "CADH6_MOUSE", "url": "https://www.uniprot.org/uniprot/P97326", "type": "external" } ], "mass": 88355.0, "length": 790, "protein_name": "Cadherin-6", "gene_name": "Cdh6", "organism": "Mouse", "refseq_name": "cadherin-6 preproprotein", "refseq_ac": [ { "id": "NP_031692", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031692", "type": "external" } ], "gene_names_uniprotkb": "Cdh6", "gene_names_refseq": "Cdh6; cad6", "protein_names_uniprotkb": "Cadherin-6; K-cadherin; Kidney cadherin", "protein_names_refseq": "K-cadherin; cadherin-6 preproprotein; kidney cadherin", "tax_id": 10090, "disease": "", "pathway": " (mmu:12563); (R-MMU-418990)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;21183079;25428506;30016717;30084848;30899004;8879495;9126293", "class_list": "", "function": "Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types., [UniProtKB]; This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. Mice lacking the encoded protein exhibit delay in mesenchyme-to-epithelial conversion and a loss of nephrons. Multiple distinct genes of the cadherin family, including this gene, are found on chromosome 15. [provided by RefSeq, Oct 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 10, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "P70393;Q3KNY8", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0030054 cell junction", "go_biological_process": "GO:0007219 Notch signaling pathway;GO:0016477 cell migration;GO:0000902 cell morphogenesis;GO:0007043 cell-cell junction assembly;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P97326-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61112-1", "uniprot_id": [ { "id": "CAB45_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61112", "type": "external" } ], "mass": 42064.0, "length": 361, "protein_name": "45 kDa calcium-binding protein", "gene_name": "Sdf4", "organism": "Mouse", "refseq_name": "45 kDa calcium-binding protein isoform 1 precursor", "refseq_ac": [ { "id": "NP_001289396", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289396", "type": "external" } ], "gene_names_uniprotkb": "Sdf4; Cab45", "gene_names_refseq": "Cab45; Sdf4", "protein_names_uniprotkb": "45 kDa calcium-binding protein; Cab45; SDF-4; Stromal cell-derived factor 4", "protein_names_refseq": "45 kDa calcium-binding protein isoform 1 precursor; 45 kDa calcium-binding protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:20318)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "16608874;26740625;30084848;32152506;34428180;8609160;8938438", "class_list": "", "function": "May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment., [UniProtKB]; This gene encodes a member of the CREC family. The encoded protein contains multiple calcium-binding EF-hand motifs. This protein localizes to the Golgi lumen and may be involved in regulating calcium dependent cellular activities. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TK84;Q3TQP8;Q61113", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005796 Golgi lumen;GO:0005886 plasma membrane;GO:0005770 late endosome", "go_biological_process": "GO:0045471 response to ethanol;GO:0045444 fat cell differentiation;GO:0099558 maintenance of synapse structure;GO:0017156 calcium-ion regulated exocytosis;GO:0021549 cerebellum development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q61112-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R0S4-3", "uniprot_id": [ { "id": "CACB4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R0S4", "type": "external" } ], "mass": 57950.0, "length": 519, "protein_name": "Voltage-dependent L-type calcium channel subunit beta-4", "gene_name": "Cacnb4", "organism": "Mouse", "refseq_name": "voltage-dependent L-type calcium channel subunit beta-4 isoform a", "refseq_ac": [ { "id": "NP_001032176", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032176", "type": "external" } ], "gene_names_uniprotkb": "Cacnb4; Cacnlb4", "gene_names_refseq": "3110038O15Rik; Cacnb4; Cchb4; lh", "protein_names_uniprotkb": "Voltage-dependent L-type calcium channel subunit beta-4; CAB4; Calcium channel voltage-dependent subunit beta 4", "protein_names_refseq": "CAB4; calcium channel voltage-dependent subunit beta 4; voltage-dependent L-type calcium channel subunit beta-4 isoform a; voltage-dependent L-type calcium channel subunit beta-4", "tax_id": 10090, "disease": "episodic ataxia type 5 (Disease Ontology:DOID:0050993); dilated cardiomyopathy (Disease Ontology:DOID:12930); generalized epilepsy (Disease Ontology:DOID:1827); episodic ataxia (Disease Ontology:DOID:963)", "pathway": " (mmu:12298); (R-MMU-112308)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;14500989;16452087;21183079;24129315;24751537;27003325;33300544", "class_list": "", "function": "Study demonstrates that the lack of the voltage-gated calcium channel beta4 subunit causes a decreased late development in cerebellar cortical networks, characterized by reduced parallel fibre-purkinje cell input, shorter purkinje cell dendrites and depressed purkinje cell output., [RefSeq, PubMed]; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UHK2;Q8BRN6;Q8CAJ9", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0005246 calcium channel regulator activity;GO:0099626 voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels;GO:0005245 voltage-gated calcium channel activity;GO:0008331 high voltage-gated calcium channel activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0016607 nuclear speck;GO:0045202 synapse;GO:0098793 presynapse", "go_biological_process": "GO:0046058 cAMP metabolic process;GO:0007528 neuromuscular junction development;GO:0008285 negative regulation of cell population proliferation;GO:0042391 regulation of membrane potential;GO:0006816 calcium ion transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8R0S4-3", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ESJ1-1", "uniprot_id": [ { "id": "CABL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ESJ1", "type": "external" } ], "mass": 61429.0, "length": 568, "protein_name": "CDK5 and ABL1 enzyme substrate 1", "gene_name": "Cables1", "organism": "Mouse", "refseq_name": "CDK5 and ABL1 enzyme substrate 1 isoform 2", "refseq_ac": [ { "id": "NP_071304", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071304", "type": "external" } ], "gene_names_uniprotkb": "Cables1; Cables", "gene_names_refseq": "Cables1; Cables; ik3-1", "protein_names_uniprotkb": "CDK5 and ABL1 enzyme substrate 1; Ik3-1; Interactor with CDK3 1", "protein_names_refseq": "CDK5 and ABL1 enzyme substrate 1 isoform 2; CDK5 and ABL1 enzyme substrate 1; cdk3-binding protein ik3-1; interactor with CDK3 1; interactor-1 with cdk3", "tax_id": 10090, "disease": "", "pathway": " (mmu:63955); (R-MMU-69202); (R-MMU-69656)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;10873625;10896159;11527406;11585773;11706030;11733001;20559324;21183079;23792637;24336072;31327733;35820727", "class_list": "", "function": "Agenesis of the corpus callosum frequency in Cables1(+/TAS) mice was significantly lower than that in Cables1(-/TAS) mice, indicating that wild-type Cables1 interfered with the dominant negative effect of Cables1(TAS)., [RefSeq, PubMed]; Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity)., [UniProtKB, PubMed]; Data show that oocytes lacking Cables1 exhibit lower basal levels of TAp63alpha and reduced accumulation of phosphorylated TAp63alpha in response to genotoxic stress., [RefSeq, PubMed]; Loss of Cables1 enhances tumor progression in the Apc(Min/+) mouse model and activates the Wnt/beta-catenin signaling pathway. Cables1 is a tumor suppressor gene on chromosome 18q in this in vivo mouse model., [RefSeq, PubMed]; Overexpression and short hairpin RNA-mediated depletion of CABLES1 protein resulted in p21(Cip/waf) up- and down-regulation. Aged mice lacking Cables1 displayed abnormalities in peripheral blood cell counts accompanied by a significant reduction in hematopoietic stem cells compartment, concomitant with an increased mobilization of progenitor cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9606, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9QNI6;Q9EPR8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0030426 growth cone;GO:0016604 nuclear body", "go_biological_process": "GO:0007399 nervous system development;GO:0051301 cell division;GO:0000082 G1/S transition of mitotic cell cycle;GO:0051726 regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9ESJ1-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JLK7-1", "uniprot_id": [ { "id": "CABP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JLK7", "type": "external" } ], "mass": 25943.0, "length": 227, "protein_name": "Calcium-binding protein 1", "gene_name": "Cabp1", "organism": "Mouse", "refseq_name": "calcium-binding protein 1 isoform 3", "refseq_ac": [ { "id": "NP_001297644", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297644", "type": "external" } ], "gene_names_uniprotkb": "Cabp1", "gene_names_refseq": "Cabp1; caldendrin", "protein_names_uniprotkb": "Calcium-binding protein 1; CaBP1", "protein_names_refseq": "calcium-binding protein 1 isoform 3", "tax_id": 10090, "disease": "temporal lobe epilepsy (Disease Ontology:DOID:3328); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:29867)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10625670;15895247;17050707;17947313;17994197;21750661;24256100;26809054;27822497;38262725", "class_list": "", "function": "Caldendrin Is a Repressor of PIEZO2 Channels and Touch Sensation in Mice. Publication Status: Online-Only, [RefSeq, PubMed]; Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels (By similarity). Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but has an opposite effect on channel function. Suppresses the calcium-dependent inactivation of CACNA1D (PubMed:17050707, PubMed:17947313). Inhibits TRPC5 channels. Prevents NMDA receptor-induced cellular degeneration (By similarity). Required for the normal transfer of light signals through the retina (PubMed:27822497)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Our results implicate CaBP1 rather than CaBP4 in conferring the anomalous slow inactivation of Ca(v)1.3 Ca(2+) currents required for auditory transmission, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JLK6", "ec_number_list": [], "go_molecular_function": "GO:0031800 type 3 metabotropic glutamate receptor binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0048306 calcium-dependent protein binding;GO:0005246 calcium channel regulator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0098885 modification of postsynaptic actin cytoskeleton;GO:0007601 visual perception;GO:0042308 negative regulation of protein import into nucleus;GO:1901385 regulation of voltage-gated calcium channel activity;GO:0007602 phototransduction", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9JLK7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q921C5-1", "uniprot_id": [ { "id": "BICD2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q921C5", "type": "external" } ], "mass": 93391.0, "length": 820, "protein_name": "Protein bicaudal D homolog 2", "gene_name": "Bicd2", "organism": "Mouse", "refseq_name": "protein bicaudal D homolog 2 isoform 1", "refseq_ac": [ { "id": "NP_001034268", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034268", "type": "external" } ], "gene_names_uniprotkb": "Bicd2; Kiaa0699", "gene_names_refseq": "Bicd2", "protein_names_uniprotkb": "Protein bicaudal D homolog 2; Bic-D 2", "protein_names_refseq": "bic-D 2; protein bicaudal D homolog 2 isoform 1; protein bicaudal D homolog 2", "tax_id": 10090, "disease": "spinal muscular atrophy with lower extremity predominant 2A (Disease Ontology:DOID:0070349); spinal muscular atrophy with lower extremity predominant 2B (Disease Ontology:DOID:0070350)", "pathway": " (mmu:76895); (R-MMU-6811436)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "11483508;12447383;12522145;18579581;20386726;21183079;21750661;22956769;23664119;24986880;25035494;25962623;26968983;31655624;32183910;34428180;35858435;40021952", "class_list": "", "function": "Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:11483508, PubMed:22956769, PubMed:24986880, PubMed:25035494). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form (PubMed:25962623). Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex (PubMed:12447383, PubMed:25962623). Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis (PubMed:20386726)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; BICD2-N transgene increased lifespan in 'low copy' SOD1-G93A ALS transgenic mice., [RefSeq, PubMed]; Elevated BICD2 DNA methylation in blood of major depressive disorder patients and reduction of depressive-like behaviors in hippocampal Bicd2-knockdown mice., [RefSeq, PubMed]; Findings demonstrate a novel, cell-intrinsic role of BICD2 in cortical neuron migration in vivo and provide new insights into BICD2-dependent dynein-mediated functions during cortical development. Publication Status: Online-Only, [RefSeq, PubMed]; Loss of BICD2 in muscle drives motor neuron loss in a developmental form of spinal muscular atrophy. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q80TU1;Q8BTE3;Q9DCL3", "ec_number_list": [], "go_molecular_function": "GO:0008093 cytoskeletal anchor activity;GO:0031267 small GTPase binding;GO:0070840 dynein complex binding;GO:0034452 dynactin binding;GO:0051959 dynein light intermediate chain binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005813 centrosome", "go_biological_process": "GO:0015031 protein transport;GO:0007018 microtubule-based movement;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0034067 protein localization to Golgi apparatus;GO:0051642 centrosome localization", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q921C5-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R164-1", "uniprot_id": [ { "id": "BPHL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R164", "type": "external" } ], "mass": 32851.0, "length": 291, "protein_name": "Serine hydrolase BPHL", "gene_name": "Bphl", "organism": "Mouse", "refseq_name": "serine hydrolase BPHL isoform 1 precursor", "refseq_ac": [ { "id": "NP_080788", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080788", "type": "external" } ], "gene_names_uniprotkb": "Bphl", "gene_names_refseq": "Bphl", "protein_names_uniprotkb": "Serine hydrolase BPHL; 3.1.-.-; Biphenyl hydrolase-like protein; L-homocysteine-thiolactonase BPHL; VACVase; Valacyclovir hydrolase; Valacyclovirase", "protein_names_refseq": "L-homocysteine-thiolactonase BPHL; VACVase; biphenyl hydrolase-like (serine hydrolase, breast epithelial mucin-associated antigen); biphenyl hydrolase-like protein; serine hydrolase BPHL isoform 1 precursor; serine hydrolase BPHL; valacyclovir hydrolase; valacyclovirase", "tax_id": 10090, "disease": "", "pathway": " (mmu:68021); (R-MMU-211945)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "21750661;23576753;23806337;25428506;30084848;30121252;33300544;34428180;35820727;37453647", "class_list": "", "function": "Specific alpha-amino acid ester serine hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol. Has homocysteine-thiolactonase activity (in vitro) and may play a significant role in the detoxification of homocysteine thiolactone in vivo. Catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir, converting them into their active forms (acyclovir and ganciclovir)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BVH2;Q8R589;Q9DCC6", "ec_number_list": [ { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0017171 serine hydrolase activity;GO:0047658 alpha-amino-acid esterase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0050667 homocysteine metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8R164-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61460-1", "uniprot_id": [ { "id": "DEPD5_MOUSE", "url": "https://www.uniprot.org/uniprot/P61460", "type": "external" } ], "mass": 180379.0, "length": 1591, "protein_name": "GATOR1 complex protein DEPDC5", "gene_name": "Depdc5", "organism": "Mouse", "refseq_name": "GATOR1 complex protein DEPDC5 isoform 3", "refseq_ac": [ { "id": "NP_001164038", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164038", "type": "external" } ], "gene_names_uniprotkb": "Depdc5; Kiaa0645", "gene_names_refseq": "Depdc5", "protein_names_uniprotkb": "GATOR1 complex protein DEPDC5; DEP domain-containing protein 5", "protein_names_refseq": "DEP domain-containing protein 5; GATOR complex protein DEPDC5; GATOR1 complex protein DEPDC5 isoform 3; GATOR1 complex protein DEPDC5", "tax_id": 10090, "disease": "familial focal epilepsy with variable foci 1 (Disease Ontology:DOID:0081421); developmental and epileptic encephalopathy (Disease Ontology:DOID:0112202); cancer (Disease Ontology:DOID:162); epilepsy (Disease Ontology:DOID:1826); focal epilepsy (Disease Ontology:DOID:2234)", "pathway": " (mmu:277854); (R-MMU-9639288)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "21750661;23542697;25428506;31219806;31548394;34418053;34428180;35820727;38411613", "class_list": "", "function": "As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the mTORC1 pathway (PubMed:31548394). In response to amino acid depletion, the GATOR1 complex has GTPase activating protein (GAP) activity and strongly increases GTP hydrolysis by RagA/RRAGA (or RagB/RRAGB) within heterodimeric Rag complexes, thereby turning them into their inactive GDP-bound form, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling (By similarity). In the presence of abundant amino acids, the GATOR1 complex is negatively regulated by GATOR2, the other GATOR subcomplex, in this amino acid-sensing branch of the TORC1 pathway (By similarity). Within the GATOR1 complex, DEPDC5 mediates direct interaction with the nucleotide-binding pocket of small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD) and coordinates their nucleotide loading states by promoting RagA/RRAGA or RagB/RRAGB into their GDP-binding state and RagC/RRAGC or RagD/RRAGD into their GTP-binding state (By similarity). However, it does not execute the GAP activity, which is mediated by NPRL2 (By similarity)., [UniProtKB, UniProtKB, PubMed]; The mTOR pathway genes MTOR, Rheb, Depdc5, Pten, and Tsc1 have convergent and divergent impacts on cortical neuron development and function. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9Q5J2;E9Q5Y0", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0044877 protein-containing complex binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0010508 positive regulation of autophagy;GO:0031669 cellular response to nutrient levels;GO:0045947 negative regulation of translational initiation;GO:0038202 TORC1 signaling", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P61460-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JIY2-1", "uniprot_id": [ { "id": "HAKAI_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JIY2", "type": "external" } ], "mass": 54444.0, "length": 491, "protein_name": "E3 ubiquitin-protein ligase Hakai", "gene_name": "Cbll1", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase Hakai isoform 1", "refseq_ac": [ { "id": "NP_001240776", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240776", "type": "external" } ], "gene_names_uniprotkb": "Cbll1; Hakai", "gene_names_refseq": "Cbll1; Hakai; c-Cbl-like", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase Hakai; 2.3.2.27; Casitas B-lineage lymphoma-transforming sequence-like protein 1; E-cadherin binding protein E7; RING-type E3 ubiquitin transferase Hakai; c-Cbl-like protein 1", "protein_names_refseq": "Casitas B-lineage lymphoma-like 1; E-cadherin binding protein E7; E3 ubiquitin-protein ligase Hakai isoform 1; E3 ubiquitin-protein ligase Hakai; RING-type E3 ubiquitin transferase Hakai; c-Cbl-like protein 1; casitas B-lineage lymphoma-transforming sequence-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:104836); (R-MMU-9766229); (R-MMU-983168); (R-MMU-9958810)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;11836526;12165405;19535458;21750661;22252131;25605945;29535189;29547716;32848054;36266428;36852467;40997131", "class_list": "", "function": "E-cadherin distribution and expression is altered in utricle epithelia with induction of apoptosis., [RefSeq, PubMed]; E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1 (PubMed:11836526, PubMed:22252131). Targets CDH1 for endocytosis and degradation (PubMed:11836526). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29535189, PubMed:29547716). Its function in the WMM complex is unknown (PubMed:29535189, PubMed:29547716)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Results suggest that Hakai is an important regulator of cell proliferation and that Hakai may be an oncoprotein and a potential molecular target for cancer treatment., [RefSeq, PubMed]; Role of the E3 ubiquitin-ligase Hakai in intestinal inflammation and cancer bowel disease. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TMC0;Q8C7W5;Q8VCL9", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.4.22.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.15", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0036396 RNA N6-methyladenosine methyltransferase complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0006397 mRNA processing;GO:0007162 negative regulation of cell adhesion;GO:0030155 regulation of cell adhesion;GO:0030335 positive regulation of cell migration;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9JIY2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O55102-1", "uniprot_id": [ { "id": "BL1S1_MOUSE", "url": "https://www.uniprot.org/uniprot/O55102", "type": "external" } ], "mass": 14281.0, "length": 125, "protein_name": "Biogenesis of lysosome-related organelles complex 1 subunit 1", "gene_name": "Bloc1s1", "organism": "Mouse", "refseq_name": "biogenesis of lysosome-related organelles complex 1 subunit 1", "refseq_ac": [ { "id": "NP_056555", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056555", "type": "external" } ], "gene_names_uniprotkb": "Bloc1s1; Gcn5l1", "gene_names_refseq": "BLOS1; Bloc1s1; Gcn5l1", "protein_names_uniprotkb": "Biogenesis of lysosome-related organelles complex 1 subunit 1; 2.3.1.-; BLOC-1 subunit 1; GCN5-like protein 1; Protein acetyltransferase BLOC1S1", "protein_names_refseq": "BLOC-1 subunit 1; GCN5 general control of amino acid synthesis-like 1; GCN5-like protein 1; biogenesis of lysosome-related organelles complex 1 subunit 1; biogenesis of lysosome-related organelles complex-1, subunit 1; general control of amino acid synthesis, yeast homolog-like 1; protein acetyltransferase BLOC1S1", "tax_id": 10090, "disease": "Hermansky-Pudlak syndrome (Disease Ontology:DOID:3753); schizophrenia (Disease Ontology:DOID:5419); metal metabolism disorder (Disease Ontology:DOID:896)", "pathway": " (mmu:14533); (R-MMU-432720); (R-MMU-432722)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "15102850;15265785;16760431;19546860;21750661;21998198;22309213;22554196;34428180;38390938;38597373;39390372;9426003", "class_list": "", "function": "Acts as a protein acetyltransferase. Negatively regulates aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5F1A and NDUFA9. Acts as a regulator of mTORC2 signaling in response to hypotoxic stress by mediating acetylation of RICTOR, thereby protecting RICTOR against ubiquitination and subsequent degradation by the proteasome., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Cardiomyocyte-specific deletion of GCN5L1 reduces lysine acetylation and attenuates diastolic dysfunction in aged mice by improving cardiac fatty acid oxidation., [RefSeq, PubMed]; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension (PubMed:16760431, PubMed:19546860, PubMed:21998198). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. The BORC complex is most probably associated with the cytosolic face of lysosomes, may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Defects in all the 5 known components of BLOC-1, including RP, cause severe Hermansky Pudlak syndrome in mice, suggesting that the subunits are nonredundant and that BLOC-1 plays a key role in organelle biogenesis., [RefSeq, PubMed]; Drp1 acetylation mediated by CDK5-AMPK-GCN5L1 axis promotes cerebral ischemic injury via facilitating mitochondrial fission. Publication Status: Online-Only, [RefSeq, PubMed]; Loss of GCN5L1 exacerbates damage in alcoholic liver disease through ferroptosis activation., [RefSeq, PubMed]; Mutations in the human genes encoding Snapin and the BLOS proteins could underlie novel forms of Hermansky-Pudlak syndrome as seen in mouse models, [RefSeq, PubMed]; These results indicate that the BLOC-1 and AP-3 protein complexes affect the targeting of SNARE and non-SNARE AP-3 cargoes and suggest a function of the BLOC-1 complex in membrane protein sorting., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9DC96", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.1.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.22.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "1.8.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "2.3.1.259", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.259", "type": "external" }, { "id": "2.3.1.57", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.57", "type": "external" }, { "id": "2.3.1.80", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.80", "type": "external" }, { "id": "4.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.-", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" } ], "go_molecular_function": "GO:0061733 protein-lysine-acetyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space;GO:0005759 mitochondrial matrix;GO:0005769 early endosome;GO:0005829 cytosol", "go_biological_process": "GO:0031175 neuron projection development;GO:0016197 endosomal transport;GO:0008089 anterograde axonal transport;GO:0032438 melanosome organization;GO:0048490 anterograde synaptic vesicle transport", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "O55102-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R3B7-1", "uniprot_id": [ { "id": "BRD8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R3B7", "type": "external" } ], "mass": 102610.0, "length": 951, "protein_name": "Bromodomain-containing protein 8", "gene_name": "Brd8", "organism": "Mouse", "refseq_name": "bromodomain-containing protein 8 isoform 2", "refseq_ac": [ { "id": "NP_001276535", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276535", "type": "external" } ], "gene_names_uniprotkb": "Brd8", "gene_names_refseq": "2610007E11Rik; 4432404P07Rik; Brd8; SMAP", "protein_names_uniprotkb": "Bromodomain-containing protein 8", "protein_names_refseq": "bromodomain-containing protein 8 isoform 2; bromodomain-containing protein 8", "tax_id": 10090, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861)", "pathway": " (mmu:78656)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "21183079;21750661;23806337;25428506;30084848;32848054;34428180;36852467;40021952;40885482;40997131", "class_list": "", "function": "May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q3TSZ2;Q8C049;Q8R583;Q8VDP0", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0046966 nuclear thyroid hormone receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0035267 NuA4 histone acetyltransferase complex;GO:0000812 Swr1 complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0006325 chromatin organization;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q8R3B7-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RRD7-1", "uniprot_id": [ { "id": "BRPF1_MOUSE", "url": "https://www.uniprot.org/uniprot/B2RRD7", "type": "external" } ], "mass": 137310.0, "length": 1212, "protein_name": "Peregrin", "gene_name": "Brpf1", "organism": "Mouse", "refseq_name": "peregrin isoform 3", "refseq_ac": [ { "id": "NP_001269056", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001269056", "type": "external" } ], "gene_names_uniprotkb": "Brpf1", "gene_names_refseq": "4833438B11Rik; 4930540D11Rik; Brpf1; Brpf2", "protein_names_uniprotkb": "Peregrin; Bromodomain and PHD finger-containing protein 1", "protein_names_refseq": "bromodomain and PHD finger-containing protein 1; peregrin isoform 3; peregrin", "tax_id": 10090, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888)", "pathway": " (mmu:78783); (R-MMU-3214847); (R-MMU-6804758)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "21183079;21750661;23806337;24646517;25773539;27939640", "class_list": "", "function": "Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (By similarity). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac) (By similarity). Some HAT complexes preferentially mediate histone H3 'Lys-23' (H3K23ac) acetylation (PubMed:27939640). Positively regulates the transcription of RUNX1 and RUNX2 (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0010698 acetyltransferase activator activity;GO:0140566 histone reader activity;GO:0043997 histone H4K12 acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0000123 histone acetyltransferase complex", "go_biological_process": "GO:0001570 vasculogenesis;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "B2RRD7-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A087WRL2-1", "uniprot_id": [ { "id": "A0A087WRL2_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A087WRL2", "type": "external" } ], "mass": 25527.0, "length": 222, "protein_name": "Predicted gene, 21865; Predicted gene, 30737; Predicted gene, 35134", "gene_name": "Gm21865; Gm35134", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gm21865; Gm35134; Gm21865; Gm30737; Gm35134", "gene_names_refseq": "", "protein_names_uniprotkb": "Predicted gene, 21865; Predicted gene, 30737; Predicted gene, 35134", "protein_names_refseq": "", "tax_id": 10090, "disease": "spermatogenic failure 4 (Disease Ontology:DOID:0070176)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0000795 synaptonemal complex", "go_biological_process": "GO:0007286 spermatid development;GO:0051321 meiotic cell cycle;GO:0035092 sperm DNA condensation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A087WRL2-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1B0GQX2-1", "uniprot_id": [ { "id": "TUNAR_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A1B0GQX2", "type": "external" } ], "mass": 5288.0, "length": 48, "protein_name": "Protein TUNAR", "gene_name": "Tunar", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Tunar", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein TUNAR; BNLN; Beta cell and neural cell-regulin; Tcl1 upstream neural differentiation-associated RNA; pTUNAR", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "35036403", "class_list": "", "function": "In neurons, plays a role in the regulation of intracellular Ca(2+), possibly by acting as an activator of ATP2A2/SERCA2, thus increasing the efficiency with which Ca(2+) is removed from the cytoplasm (PubMed:35036403). Inhibits differentiation of embryonic stem cells into neurons and inhibits neurite outgrowth, likely as a result of its role in intracellular Ca(2+) regulation (PubMed:35036403). In pancreatic beta cells, lowers Ca(2+) levels in the endoplasmic reticulum and enhances glucose-stimulated insulin secretion (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051117 ATPase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0045665 negative regulation of neuron differentiation;GO:0045931 positive regulation of mitotic cell cycle;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0048812 neuron projection morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A1B0GQX2-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2A590-1", "uniprot_id": [ { "id": "A2A590_MOUSE", "url": "https://www.uniprot.org/uniprot/A2A590", "type": "external" } ], "mass": 12465.0, "length": 122, "protein_name": "Keratin associated protein 1-5", "gene_name": "Krtap1-5", "organism": "Mouse", "refseq_name": "keratin associated protein 1-5", "refseq_ac": [ { "id": "NP_081433", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081433", "type": "external" } ], "gene_names_uniprotkb": "Krtap1-5", "gene_names_refseq": "2310043L02Rik; Krtap1-5", "protein_names_uniprotkb": "Keratin associated protein 1-5", "protein_names_refseq": "keratin associated protein 1-5", "tax_id": 10090, "disease": "", "pathway": " (mmu:69664); (R-MMU-6805567)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0045095 keratin filament", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2A590-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AEI7-1", "uniprot_id": [ { "id": "A2AEI7_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AEI7", "type": "external" } ], "mass": 57108.0, "length": 503, "protein_name": "T-complex 11 family, X-linked 2", "gene_name": "Tcp11x2", "organism": "Mouse", "refseq_name": "T-complex protein 11 homolog", "refseq_ac": [ { "id": "NP_082228", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082228", "type": "external" } ], "gene_names_uniprotkb": "Tcp11x2; 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Gm438", "gene_names_refseq": "Aadacl4fm5; Gm438", "protein_names_uniprotkb": "AADACL4 family member 5", "protein_names_refseq": "arylacetamide deacetylase-like 4-like; novel alpha/beta hydrolase fold domain containing protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:329993)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016787 hydrolase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B1ASB3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1AX30-1", "uniprot_id": [ { "id": "B1AX30_MOUSE", "url": "https://www.uniprot.org/uniprot/B1AX30", "type": "external" } ], "mass": 20628.0, "length": 191, "protein_name": "RIKEN cDNA 1700031F05 gene", "gene_name": "1700031F05Rik", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC73300", "refseq_ac": [ { "id": "NP_082772", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082772", "type": "external" } ], "gene_names_uniprotkb": "1700031F05Rik", "gene_names_refseq": "1700031F05Rik", "protein_names_uniprotkb": "RIKEN cDNA 1700031F05 gene", "protein_names_refseq": "uncharacterized protein LOC73300", "tax_id": 10090, "disease": "", "pathway": " (mmu:73300)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B1AX30-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2KF05-1", "uniprot_id": [ { "id": "BRPF3_MOUSE", "url": "https://www.uniprot.org/uniprot/B2KF05", "type": "external" } ], "mass": 135294.0, "length": 1204, "protein_name": "Bromodomain and PHD finger-containing protein 3", "gene_name": "Brpf3", "organism": "Mouse", "refseq_name": "bromodomain and PHD finger-containing protein 3", "refseq_ac": [ { "id": "NP_001074784", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074784", "type": "external" } ], "gene_names_uniprotkb": "Brpf3", "gene_names_refseq": "Brpf3; mKIAA1286", "protein_names_uniprotkb": "Bromodomain and PHD finger-containing protein 3", "protein_names_refseq": "bromodomain and PHD finger-containing protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:268936); (R-MMU-114608); (R-MMU-3214847); (R-MMU-6804758)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "21750661;23806337;26677226", "class_list": "", "function": "Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity. Plays a role in DNA replication initiation by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby facilitating the activation of replication origins. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity., [UniProtKB, UniProtKB]; These results indicate that BRPF3 forms a functional tetrameric complex with HBO1 but is not required for mouse development and survival, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A3B2WAQ0;Q3TRM7", "ec_number_list": [], "go_molecular_function": "GO:0043997 histone H4K12 acetyltransferase activity;GO:0008270 zinc ion binding;GO:0043995 histone H4K5 acetyltransferase activity;GO:0043996 histone H4K8 acetyltransferase activity;GO:0036408 histone H3K14 acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000123 histone acetyltransferase complex;GO:0070776 MOZ/MORF histone acetyltransferase complex", "go_biological_process": "GO:0050793 regulation of developmental process;GO:0006338 chromatin remodeling;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0045740 positive regulation of DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "B2KF05-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "C3VD30-1", "uniprot_id": [ { "id": "ZAR1L_MOUSE", "url": "https://www.uniprot.org/uniprot/C3VD30", "type": "external" } ], "mass": 33765.0, "length": 291, "protein_name": "Protein ZAR1-like", "gene_name": "Zar1l", "organism": "Mouse", "refseq_name": "protein ZAR1-like", "refseq_ac": [ { "id": "NP_001153165", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153165", "type": "external" } ], "gene_names_uniprotkb": "Zar1l; Zar2", "gene_names_refseq": "XM_359419; Zar1l", "protein_names_uniprotkb": "Protein ZAR1-like; Zygote arrest protein 1-like; Zygote arrest protein 2", "protein_names_refseq": "ZAR1-like protein; protein ZAR1-like; zygote arrest protein 1-like; zygote arrest protein 2; zygotic arrest 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:545824)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "20014101;31598710", "class_list": "", "function": "A previously unrecognized role of ZAR1/2 in regulating the maternal transcriptome and translational activation in maturing oocytes., [RefSeq, PubMed]; ZAR1L and ZAR1 may comprise a novel family of processing-body/chromatoid-body components that potentially function as RNA regulators in early embryos., [RefSeq, PubMed]; mRNA-binding protein required for maternal mRNA storage, translation and degradation during oocyte maturation (PubMed:31598710). Probably promotes formation of some phase-separated membraneless compartment that stores maternal mRNAs in oocytes: acts by undergoing liquid-liquid phase separation upon binding to maternal mRNAs (By similarity). Binds to the 3'-UTR of maternal mRNAs, inhibiting their translation (PubMed:31598710)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003730 mRNA 3'-UTR binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0036464 cytoplasmic ribonucleoprotein granule;GO:0043232 intracellular membraneless organelle", "go_biological_process": "GO:0017148 negative regulation of translation;GO:0001556 oocyte maturation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "C3VD30-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3YXE9-1", "uniprot_id": [ { "id": "D3YXE9_MOUSE", "url": "https://www.uniprot.org/uniprot/D3YXE9", "type": "external" } ], "mass": 19408.0, "length": 172, "protein_name": "cDNA sequence BC048679", "gene_name": "BC048679", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC210321 isoform 1", "refseq_ac": [ { "id": "NP_001180203", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180203", "type": "external" } ], "gene_names_uniprotkb": "BC048679", "gene_names_refseq": "BC048679", "protein_names_uniprotkb": "cDNA sequence BC048679", "protein_names_refseq": "epididymal protein Av381126; 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[provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VFM4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VGB3-1", "uniprot_id": [ { "id": "Q8VGB3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VGB3", "type": "external" } ], "mass": 35336.0, "length": 321, "protein_name": "Olfactory receptor family 10 subfamily S member 1", "gene_name": "Or10s1", "organism": "Mouse", "refseq_name": "olfactory receptor family 10 subfamily S member 1", "refseq_ac": [ { "id": "NP_667065", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_667065", "type": "external" } ], "gene_names_uniprotkb": "Or10s1; Olfr982", "gene_names_refseq": "MOR223-4; Olfr982; Or10s1", "protein_names_uniprotkb": "Olfactory receptor family 10 subfamily S member 1", "protein_names_refseq": "GA_x6K02T2PVTD-33772307-33773260; olfactory receptor 982; olfactory receptor MOR223-4; olfactory receptor family 10 subfamily S member 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:258853); (R-MMU-381753)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VGB3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CZN7-1", "uniprot_id": [ { "id": "GLYM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CZN7", "type": "external" } ], "mass": 55759.0, "length": 504, "protein_name": "Serine hydroxymethyltransferase, mitochondrial", "gene_name": "Shmt2", "organism": "Mouse", "refseq_name": "serine hydroxymethyltransferase, mitochondrial isoform 2", "refseq_ac": [ { "id": "NP_001239245", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239245", "type": "external" } ], "gene_names_uniprotkb": "Shmt2", "gene_names_refseq": "2700043D08Rik; SHMT; Shmt2", "protein_names_uniprotkb": "Serine hydroxymethyltransferase, mitochondrial; 2.1.2.1; Glycine hydroxymethyltransferase; SHMT; Serine methylase", "protein_names_refseq": "glycine hydroxymethyltransferase; serine hydroxymethyltransferase, mitochondrial isoform 2; serine hydroxymethyltransferase, mitochondrial; serine methylase", "tax_id": 10090, "disease": "neurodevelopmental disorder with cardiomyopathy, spasticity, and brain abnormalities (Disease Ontology:DOID:0070543); alcohol use disorder (Disease Ontology:DOID:1574); cancer (Disease Ontology:DOID:162); schizophrenia (Disease Ontology:DOID:5419); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (mmu:108037); (R-MMU-196757); (R-MMU-9013408); (R-MMU-9837999)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "23806337;29323231;29452640;33725478;34428180;37453647;37507081;37828378;38347107;38723737;39456851", "class_list": "", "function": "Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis (By similarity). Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate (By similarity). Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA (By similarity). Also required for mitochondrial translation by producing 5,10-methylenetetrahydrofolate; 5,10-methylenetetrahydrofolate providing methyl donors to produce the taurinomethyluridine base at the wobble position of some mitochondrial tRNAs (PubMed:29452640). Associates with mitochondrial DNA (By similarity). In addition to its role in mitochondria, also plays a role in the deubiquitination of target proteins as component of the BRISC complex: required for IFNAR1 deubiquitination by the BRISC complex (By similarity)., [UniProtKB, UniProtKB, PubMed]; Mitochondrial outer membrane protein Samm50 protects against hypoxia-induced cardiac injury by interacting with Shmt2., [RefSeq, PubMed]; SHMT2 reduces fatty liver but is necessary for liver inflammation and fibrosis in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Serine Hydroxymethyltransferase 2 Deficiency in the Hematopoietic System Disrupts Erythropoiesis and Induces Anemia in Murine Models. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TFD0;Q99K87", "ec_number_list": [ { "id": "2.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.2.1", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "1.1.98.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.98.-", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0030170 pyridoxal phosphate binding;GO:0042802 identical protein binding;GO:0016597 amino acid binding;GO:0004372 glycine hydroxymethyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006545 glycine biosynthetic process;GO:0008284 positive regulation of cell population proliferation;GO:0051262 protein tetramerization;GO:0051289 protein homotetramerization;GO:0070536 protein K63-linked deubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9CZN7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02340-1", "uniprot_id": [ { "id": "P53_MOUSE", "url": "https://www.uniprot.org/uniprot/P02340", "type": "external" } ], "mass": 43458.0, "length": 390, "protein_name": "Cellular tumor antigen p53", "gene_name": "Tp53; Trp53", "organism": "Mouse", "refseq_name": "cellular tumor antigen p53 isoform b", "refseq_ac": [ { "id": "NP_001120705", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001120705", "type": "external" } ], "gene_names_uniprotkb": "Tp53; Trp53; P53; Trp53", "gene_names_refseq": "Tp53; Trp53; bbl; bfy; bhy; p44; p53", "protein_names_uniprotkb": "Cellular tumor antigen p53; Tumor suppressor p53", "protein_names_refseq": "ME-delta123p53; cellular tumor antigen p53 isoform b; cellular tumor antigen p53; mutant p53; p53 cellular tumor antigen; tumor suppressor p53; tumor supressor p53", "tax_id": 10090, "disease": "angiosarcoma (Disease Ontology:DOID:0001816); pterygium (Disease Ontology:DOID:0002116); diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745); CHARGE syndrome (Disease Ontology:DOID:0050834); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); medulloblastoma (Disease Ontology:DOID:0050902); myelodysplastic syndrome (Disease Ontology:DOID:0050908); pre-malignant neoplasm (Disease Ontology:DOID:0060071); ductal carcinoma in situ (Disease Ontology:DOID:0060074); colorectal carcinoma (Disease Ontology:DOID:0080199); adenoid cystic carcinoma (Disease Ontology:DOID:0080202); B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); graft-versus-host disease (Disease Ontology:DOID:0081267); traumatic brain injury (Disease Ontology:DOID:0081292); T-cell non-Hodgkin lymphoma (Disease Ontology:DOID:0081312); Li-Fraumeni syndrome 1 (Disease Ontology:DOID:0111503); mismatch repair cancer syndrome (Disease Ontology:DOID:0112182); prostate cancer (Disease Ontology:DOID:10283); aggressive NK-cell leukemia (Disease Ontology:DOID:1035); stomach cancer (Disease Ontology:DOID:10534); primary open angle glaucoma (Disease Ontology:DOID:1070); nasal cavity cancer (Disease Ontology:DOID:10811); cholesteatoma of middle ear (Disease Ontology:DOID:10964); urinary bladder cancer (Disease Ontology:DOID:11054); sarcoma (Disease Ontology:DOID:1115); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); Graves' disease (Disease Ontology:DOID:12361); leukemia (Disease Ontology:DOID:1240); dilated cardiomyopathy (Disease Ontology:DOID:12930); paranasal sinus benign neoplasm (Disease Ontology:DOID:1350); low tension glaucoma (Disease Ontology:DOID:13544); endometrial cancer (Disease Ontology:DOID:1380); disease of cellular proliferation (Disease Ontology:DOID:14566); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); squamous cell carcinoma (Disease Ontology:DOID:1749); pancreatic cancer (Disease Ontology:DOID:1793); melanoma (Disease Ontology:DOID:1909); basal cell carcinoma (Disease Ontology:DOID:2513); hematologic cancer (Disease Ontology:DOID:2531); choroid plexus papilloma (Disease Ontology:DOID:2626); transitional cell carcinoma (Disease Ontology:DOID:2671); dyskeratosis congenita (Disease Ontology:DOID:2729); endometrial adenocarcinoma (Disease Ontology:DOID:2870); endometrial carcinoma (Disease Ontology:DOID:2871); testicular cancer (Disease Ontology:DOID:2998); Li-Fraumeni syndrome (Disease Ontology:DOID:3012); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); serous cystadenocarcinoma (Disease Ontology:DOID:3114); ischemia (Disease Ontology:DOID:326); osteosarcoma (Disease Ontology:DOID:3347); coronary artery disease (Disease Ontology:DOID:3393); cervical adenocarcinoma (Disease Ontology:DOID:3702); gastric adenocarcinoma (Disease Ontology:DOID:3717); cervical squamous cell carcinoma (Disease Ontology:DOID:3744); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); papillary thyroid carcinoma (Disease Ontology:DOID:3969); coronary restenosis (Disease Ontology:DOID:4247); renal cell carcinoma (Disease Ontology:DOID:4450); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); bronchiolo-alveolar adenocarcinoma (Disease Ontology:DOID:4926); myelofibrosis (Disease Ontology:DOID:4971); ovary serous adenocarcinoma (Disease Ontology:DOID:5744); oral submucous fibrosis (Disease Ontology:DOID:5773); malignant peripheral nerve sheath tumor (Disease Ontology:DOID:5940); hepatocellular carcinoma (Disease Ontology:DOID:684); Leber hereditary optic neuropathy (Disease Ontology:DOID:705); pancreatic intraductal papillary-mucinous neoplasm (Disease Ontology:DOID:7575); meninges sarcoma (Disease Ontology:DOID:7614); vascular dementia (Disease Ontology:DOID:8725); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261); multiple myeloma (Disease Ontology:DOID:9538); oral mucosa leukoplakia (Disease Ontology:DOID:9655)", "pathway": " (mmu:22059); (R-MMU-2559580); (R-MMU-2559584); (R-MMU-2559585); (R-MMU-2559586); (R-MMU-349425); (R-MMU-5689880); (R-MMU-5689896); (R-MMU-5693565); (R-MMU-6804754); (R-MMU-6804756); (R-MMU-6804757); (R-MMU-6804758); (R-MMU-6804759); (R-MMU-6804760); (R-MMU-6811555); (R-MMU-69473); (R-MMU-69481); (R-MMU-69541); (R-MMU-69895); (R-MMU-8852276); (R-MMU-8941855); (R-MMU-9833482)", "pathway_count": 23, "publication_count": 52, "publication_id_list": "10094408;10403253;10644996;11152481;11560998;11672522;11706030;12494467;12702766;1406686;14719112;15195100;15526030;16717092;17139084;17254968;1766680;17719541;17876829;18022393;18978813;19151705;19556538;20673990;2145148;21750661;221923;22726440;23806337;24051492;24240685;25732823;27581076;28095779;28528544;28751718;29281826;3006031;3023970;31219806;31599954;32927737;33200984;3329909;34203471;34428180;35122041;36210013;36265223;6092064;6379601;6646235", "class_list": "", "function": "Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence. Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Negatively regulates cell division by controlling expression of a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mice deficient for this gene are developmentally normal but are susceptible to spontaneous tumors. Evidence to date shows that this gene contains one promoter, in contrast to alternative promoters of the human gene, and transcribes a few of splice variants which encode different isoforms, although the biological validity or the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 79, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9QUP3", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0003677 DNA binding;GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity;GO:0051087 protein-folding chaperone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:0016032 viral process;GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 5.5, "record_id": "P02340-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A338P6I9-1", "uniprot_id": [ { "id": "A0A338P6I9_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A338P6I9", "type": "external" } ], "mass": 6771.0, "length": 59, "protein_name": "Predicted gene, 56451", "gene_name": "Gm56451", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gm56451", "gene_names_refseq": "", "protein_names_uniprotkb": "Predicted gene, 56451", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A338P6I9-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q921C3-1", "uniprot_id": [ { "id": "BRWD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q921C3", "type": "external" } ], "mass": 259228.0, "length": 2304, "protein_name": "Bromodomain and WD repeat-containing protein 1", "gene_name": "Brwd1", "organism": "Mouse", "refseq_name": "bromodomain and WD repeat-containing protein 1 isoform B", "refseq_ac": [ { "id": "NP_001096649", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096649", "type": "external" } ], "gene_names_uniprotkb": "Brwd1; Wdr9", "gene_names_refseq": "5330419I02Rik; Brwd1; D530019K20Rik; G1-403-16; Wdr9; repro5", "protein_names_uniprotkb": "Bromodomain and WD repeat-containing protein 1; WD repeat-containing protein 9", "protein_names_refseq": "WD repeat domain 9; WD repeat-containing protein 9; bromodomain and WD repeat-containing protein 1 isoform B; bromodomain and WD repeat-containing protein 1", "tax_id": 10090, "disease": "primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": " (mmu:93871); (R-MMU-1266695); (R-MMU-3247509)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "12359327;12889071;15345747;16452087;17242355;17525332;21183079;21750661;34418053", "class_list": "", "function": "May be a transcriptional activator (PubMed:12889071). May be involved in chromatin remodeling (PubMed:12889071). Required for regulation of cell morphology and cytoskeletal organization (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 28, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QAC1;Q921C2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0031514 motile cilium", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007010 cytoskeleton organization;GO:0008360 regulation of cell shape", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q921C3-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A338P6Q3-1", "uniprot_id": [ { "id": "A0A338P6Q3_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A338P6Q3", "type": "external" } ], "mass": 67948.0, "length": 587, "protein_name": "RIKEN cDNA A630089N07 gene", "gene_name": "A630089N07Rik", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC320586 isoform b", "refseq_ac": [ { "id": "NP_001423213", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001423213", "type": "external" } ], "gene_names_uniprotkb": "A630089N07Rik", "gene_names_refseq": "A630089N07Rik", "protein_names_uniprotkb": "RIKEN cDNA A630089N07 gene", "protein_names_refseq": "uncharacterized protein LOC320586 isoform b", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, 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"go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A338P6Q3-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3B2WCP9-1", "uniprot_id": [ { "id": "A0A3B2WCP9_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A3B2WCP9", "type": "external" } ], "mass": 10022.0, "length": 86, "protein_name": "Predicted gene, 49835", "gene_name": "Gm49835", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gm49835", "gene_names_refseq": "", "protein_names_uniprotkb": "Predicted gene, 49835", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005186 pheromone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A3B2WCP9-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3B2WD42-1", "uniprot_id": [ { "id": "A0A3B2WD42_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A3B2WD42", "type": "external" } ], "mass": 7229.0, "length": 68, "protein_name": "Guanine nucleotide-binding protein subunit gamma", "gene_name": "Gng5c", "organism": "Mouse", "refseq_name": "G protein subunit gamma 5C", "refseq_ac": [ { "id": "NP_001423242", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001423242", "type": "external" } ], "gene_names_uniprotkb": "Gng5c; Gm4356", "gene_names_refseq": "100043318; Gm4356; Gng5c", "protein_names_uniprotkb": "Guanine nucleotide-binding protein subunit gamma", "protein_names_refseq": "G protein subunit gamma 5C; guanine nucleotide binding protein (G protein), gamma 5 pseudogene", "tax_id": 10090, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:100043318)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031681 G-protein beta-subunit binding", "go_cellular_component": "GO:0005834 heterotrimeric G-protein complex", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A3B2WD42-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3B2WD63-1", "uniprot_id": [ { "id": "A0A3B2WD63_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A3B2WD63", "type": "external" } ], "mass": 56980.0, "length": 508, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "Gm7356", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gm7356", "gene_names_refseq": "", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May play a role in sperm motility, especially in the regulation of flagellar function., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A3B2WD63-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A668KLA7-1", "uniprot_id": [ { "id": "A0A668KLA7_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A668KLA7", "type": "external" } ], "mass": 32682.0, "length": 296, "protein_name": "Predicted gene 7582", "gene_name": "Gm7582", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gm7582", "gene_names_refseq": "", "protein_names_uniprotkb": "Predicted gene 7582", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A668KLA7-1", "record_type": "protein", "filter_code": "0000000.1000100.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A6I8MX03-1", "uniprot_id": [ { "id": "A0A6I8MX03_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A6I8MX03", "type": "external" } ], "mass": 24213.0, "length": 223, "protein_name": "E2 ubiquitin-conjugating enzyme", "gene_name": "Ube2srt", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ube2srt", "gene_names_refseq": "", "protein_names_uniprotkb": "E2 ubiquitin-conjugating enzyme; 2.3.2.23", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as an E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0004842 ubiquitin-protein transferase activity;GO:0061631 ubiquitin conjugating enzyme activity;GO:0010997 anaphase-promoting complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005680 anaphase-promoting complex", "go_biological_process": "GO:0051301 cell division;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010458 exit from mitosis;GO:0031145 anaphase-promoting complex-dependent catabolic process;GO:0070979 protein K11-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A6I8MX03-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A668KLD8-1", "uniprot_id": [ { "id": "A0A668KLD8_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A668KLD8", "type": "external" } ], "mass": 32609.0, "length": 296, "protein_name": "Predicted pseudogene 15433", "gene_name": "Gm15433", "organism": "Mouse", "refseq_name": "predicted pseudogene 15433", "refseq_ac": [ { "id": "NP_001423007", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001423007", "type": "external" } ], "gene_names_uniprotkb": "Gm15433", "gene_names_refseq": "Gm15433", "protein_names_uniprotkb": "Predicted pseudogene 15433", "protein_names_refseq": "predicted pseudogene 15433", "tax_id": 10090, "disease": "", "pathway": " (mmu:100503433)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A668KLD8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35625-1", "uniprot_id": [ { "id": "AXIN1_MOUSE", "url": "https://www.uniprot.org/uniprot/O35625", "type": "external" } ], "mass": 96276.0, "length": 863, "protein_name": "Axin-1", "gene_name": "Axin1", "organism": "Mouse", "refseq_name": "axin-1 isoform 1", "refseq_ac": [ { "id": "NP_001153070", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153070", "type": "external" } ], "gene_names_uniprotkb": "Axin1; Axin; Fu", "gene_names_refseq": "Axin1; Axin; Fu; Kb; Ki; fused; kinky; knobbly", "protein_names_uniprotkb": "Axin-1; Axis inhibition protein 1; Protein Fused", "protein_names_refseq": "axin-1 isoform 1; axis inhibition protein 1; protein Fused", "tax_id": 10090, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); urinary bladder cancer (Disease Ontology:DOID:11054); lung cancer (Disease Ontology:DOID:1324); cancer (Disease Ontology:DOID:162); colon cancer (Disease Ontology:DOID:219); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:12005); (R-MMU-195253); (R-MMU-196299); (R-MMU-201681); (R-MMU-4641257); (R-MMU-4641262); (R-MMU-5689880)", "pathway_count": 7, "publication_count": 19, "publication_id_list": "10581160;11336703;12183362;12223491;15063782;15262978;15526030;16815997;17681137;18632848;19141611;19581931;21183079;21750661;24093678;25002183;31219806;34428180;9230313", "class_list": "", "function": "Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (By similarity). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway (PubMed:12223491, PubMed:17681137). In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B (By similarity). Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (By similarity). Also a component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development (PubMed:15526030). Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation (PubMed:15526030). Activates the AMP-activated protein kinase (AMPK) in response to calorie restriction by acting as a molecular adapter: recruited to late endosome membrane by the V-ATPase complex downstream of TULP3, and mediates association between STK11 and its AMPK substrates PRKAA1 and/or PRKAA2, leading to AMPK activation (PubMed:24093678, PubMed:25002183)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005102 signaling receptor binding;GO:0019899 enzyme binding;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0001934 positive regulation of protein phosphorylation;GO:0006913 nucleocytoplasmic transport;GO:0010629 negative regulation of gene expression;GO:0046330 positive regulation of JNK cascade", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "O35625-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q148W0-1", "uniprot_id": [ { "id": "AT8B1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q148W0", "type": "external" } ], "mass": 143798.0, "length": 1251, "protein_name": "Phospholipid-transporting ATPase IC", "gene_name": "Atp8b1", "organism": "Mouse", "refseq_name": "phospholipid-transporting ATPase IC", "refseq_ac": [ { "id": "NP_001001488", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001488", "type": "external" } ], "gene_names_uniprotkb": "Atp8b1", "gene_names_refseq": "Atp8b1; FIC1; Ic", "protein_names_uniprotkb": "Phospholipid-transporting ATPase IC; 7.6.2.1; ATPase class I type 8B member 1; P4-ATPase flippase complex alpha subunit ATP8B1", "protein_names_refseq": "ATPase 8B1, p type; ATPase B1, class I; P4-ATPase flippase complex alpha subunit ATP8B1; aminophospholipid translocase; familial intrahepatic cholestasis type I; phospholipid-transporting ATPase IC; probable phospholipid-transporting ATPase IC", "tax_id": 10090, "disease": "progressive familial intrahepatic cholestasis (Disease Ontology:DOID:0070221); progressive familial intrahepatic cholestasis 1 (Disease Ontology:DOID:0070226); intrahepatic cholestasis of pregnancy 1 (Disease Ontology:DOID:0070228); benign recurrent intrahepatic cholestasis 1 (Disease Ontology:DOID:0070231); intrahepatic cholestasis (Disease Ontology:DOID:1852)", "pathway": " (mmu:54670); (R-MMU-936837)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "14976163;15496606;17242355;19478059;20126555;20852622;21183079;21475228;21750661;21820390;21952136;26416959;30018401;33649389;34428180;35204783;36273194", "class_list": "", "function": "Acinar ATP8b1/LPC pathway promotes macrophage efferocytosis and clearance of inflammation during chronic pancreatitis development. Erratum:[Cell Death Dis. 2022 Nov 7;13(11):930. doi: 10.1038/s41419-022-05374-8. PMID: 36344486] Publication Status: Online-Only, [RefSeq, PubMed]; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of phospholipids, in particular phosphatidylcholines (PC), from the outer to the inner leaflet of the plasma membrane (By similarity). May participate in the establishment of the canalicular membrane integrity by ensuring asymmetric distribution of phospholipids in the canicular membrane (PubMed:21820390). Thus may have a role in the regulation of bile acids transport into the canaliculus, uptake of bile acids from intestinal contents into intestinal mucosa or both and protect hepatocytes from bile salts (PubMed:14976163, PubMed:20126555, PubMed:21820390). Involved in the microvillus formation in polarized epithelial cells; the function seems to be independent from its flippase activity (By similarity). Participates in correct apical membrane localization of CDC42, CFTR and SLC10A2 (PubMed:26416959). Enables CDC42 clustering at the apical membrane during enterocyte polarization through the interaction between CDC42 polybasic region and negatively charged membrane lipids provided by ATP8B1 (PubMed:26416959). Together with TMEM30A is involved in uptake of the synthetic drug alkylphospholipid perifosine (By similarity). Required for the preservation of cochlear hair cells in the inner ear (PubMed:19478059). According PubMed:20852622 is proposed to act as cardiolipin transporter during inflammatory injury; the function is questioned by PubMed:21475228 (PubMed:20852622, PubMed:21475228)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Fic1 is expressed in a tissue-specific and developmentally regulated fashion at the apical membranes of epithelial cells, [RefSeq, PubMed]; Matrix Metalloproteinase 7 Expression and Apical Epithelial Defects in Atp8b1 Mutant Mouse Model of Pulmonary Fibrosis. Publication Status: Online-Only, [RefSeq, PubMed]; Mutation disrupts bile salt homeostasis without impairment of canalicular bile secretion, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3U010;Q6R964", "ec_number_list": [ { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005319 lipid transporter activity;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0090554 phosphatidylcholine floppase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0015721 bile acid and bile salt transport;GO:0045892 negative regulation of DNA-templated transcription;GO:0045332 phospholipid translocation;GO:0015711 organic anion transport;GO:0007605 sensory perception of sound", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q148W0-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99ML1-1", "uniprot_id": [ { "id": "BBC3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99ML1", "type": "external" } ], "mass": 20749.0, "length": 193, "protein_name": "Bcl-2-binding component 3", "gene_name": "Bbc3", "organism": "Mouse", "refseq_name": "bcl-2-binding component 3 isoform a", "refseq_ac": [ { "id": "NP_573497", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_573497", "type": "external" } ], "gene_names_uniprotkb": "Bbc3; Puma", "gene_names_refseq": "Bbc3; PUMA/JFY1; PUMA", "protein_names_uniprotkb": "Bcl-2-binding component 3; p53 up-regulated modulator of apoptosis", "protein_names_refseq": "BH3-only; Bcl-2 binding component 3; bcl-2-binding component 3 isoform a; bcl-2-binding component 3; p53 up-regulated modulator of apoptosis", "tax_id": 10090, "disease": "transient cerebral ischemia (Disease Ontology:DOID:224); intermittent claudication (Disease Ontology:DOID:3669); lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (mmu:170770)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "11463391;14500851;14585359;15192153;18462686;18589438;21159964;21750661;22761832;34428180;38110554;38489392", "class_list": "", "function": "Combined absence of TRP53 target genes ZMAT3, PUMA and p21 cause a high incidence of cancer in mice., [RefSeq, PubMed]; Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis (By similarity). Promotes partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53, releasing the bound p53/TP53 to induce apoptosis (By similarity). Regulates ER stress-induced neuronal apoptosis (PubMed:21159964, PubMed:22761832)., [UniProtKB, UniProtKB, PubMed, PubMed]; P53 and BCL-2 family proteins PUMA and NOXA define competitive fitness in pluripotent cell competition. Publication Status: Online-Only, [RefSeq, PubMed]; PUMA shRNAs were unable to cooperate with oncogenic ras in transformation, [RefSeq, PubMed]; Puma and Noxa are critical mediators of the apoptotic responses induced by p53 and other agents, [RefSeq, PubMed]; Puma as a principal mediator of cell death in response to diverse apoptotic signals, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051117 ATPase binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005740 mitochondrial envelope", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0097190 apoptotic signaling pathway;GO:0070245 positive regulation of thymocyte apoptotic process;GO:0071456 cellular response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q99ML1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56480-1", "uniprot_id": [ { "id": "ATPB_MOUSE", "url": "https://www.uniprot.org/uniprot/P56480", "type": "external" } ], "mass": 56300.0, "length": 529, "protein_name": "ATP synthase F(1) complex catalytic subunit beta, mitochondrial", "gene_name": "Atp5f1b", "organism": "Mouse", "refseq_name": "ATP synthase F(1) complex catalytic subunit beta, mitochondrial precursor", "refseq_ac": [ { "id": "NP_058054", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058054", "type": "external" } ], "gene_names_uniprotkb": "Atp5f1b; Atp5b", "gene_names_refseq": "Atp5b; Atp5f1b", "protein_names_uniprotkb": "ATP synthase F(1) complex catalytic subunit beta, mitochondrial; 7.1.2.2; ATP synthase F1 subunit beta", "protein_names_refseq": "ATP synthase F(1) complex catalytic subunit beta, mitochondrial precursor; ATP synthase F(1) complex catalytic subunit beta, mitochondrial; ATP synthase subunit beta, mitochondrial; ATP synthase, H+ transporting mitochondrial F1 complex, alpha subunit; ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit; mitochondrial ATP synthase, H+ transporting F1 complex beta subunit", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); polycystic ovary syndrome (Disease Ontology:DOID:11612); transient cerebral ischemia (Disease Ontology:DOID:224); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:11947); (R-MMU-1268020); (R-MMU-163210); (R-MMU-8949613); (R-MMU-9837999)", "pathway_count": 5, "publication_count": 36, "publication_id_list": "10657236;16075062;16393994;16751257;17208939;17438143;19941651;21183079;21281446;22645316;22872234;23576753;23806337;25605945;26495903;26740625;30084848;30779550;31219806;31599954;31616917;32152506;33300544;33725478;34260942;34428180;35820727;36064721;36210013;36288343;37453647;37507081;39392752;39627609;39927985;40684658", "class_list": "glycogene", "function": "Catalytic subunit beta, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (Probable) (PubMed:21281446). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). With the subunit alpha (ATP5F1A), forms the catalytic core in the F(1) domain (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed]; Mitochondrial MOF regulates energy metabolism in heart failure via ATP5B hyperacetylation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 11, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q0QEP4;Q3TFD7;Q3TIP9;Q3TK44;Q3TWD5;Q3TX28;Q3U6U4;Q3U774;Q3UB69;Q3UF69;Q8CI65;Q8VEJ5;Q9CTI7;Q9CWX7", "ec_number_list": [ { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "2.1.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.3.3", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "2.5.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.39", "type": "external" }, { "id": "1.1.98.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.98.-", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.1.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.38", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "1.1.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.41", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0043531 ADP binding;GO:0005509 calcium ion binding;GO:0043532 angiostatin binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0006629 lipid metabolic process;GO:0006754 ATP biosynthetic process;GO:0006898 receptor-mediated endocytosis;GO:0043536 positive regulation of blood vessel endothelial cell migration", "synthesized_glycan_count": 0, "hit_score": 4.1, "record_id": "P56480-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001001.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BKX1-1", "uniprot_id": [ { "id": "BAIP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BKX1", "type": "external" } ], "mass": 59237.0, "length": 535, "protein_name": "BAR/IMD domain-containing adapter protein 2", "gene_name": "Baiap2", "organism": "Mouse", "refseq_name": "BAR/IMD domain-containing adapter protein 2 isoform c", "refseq_ac": [ { "id": "NP_001032843", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032843", "type": "external" } ], "gene_names_uniprotkb": "Baiap2", "gene_names_refseq": "Baiap2; IRSp53", "protein_names_uniprotkb": "BAR/IMD domain-containing adapter protein 2; BAI-associated protein 2; BAI1-associated protein 2; Brain-specific angiogenesis inhibitor 1-associated protein 2; IRSp53; Insulin receptor substrate p53; Insulin receptor substrate protein of 53 kDa; Insulin receptor tyrosine kinase 53 kDa substrate", "protein_names_refseq": "BAI-associated protein 2; BAI1-associated protein 2; BAR/IMD domain-containing adapter protein 2 isoform c; BAR/IMD domain-containing adapter protein 2; insulin receptor substrate p53; insulin receptor substrate protein of 53 kDa; insulin receptor tyrosine kinase 53 kDa substrate", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); Alzheimer's disease (Disease Ontology:DOID:10652); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); Gilles de la Tourette syndrome (Disease Ontology:DOID:11119)", "pathway": " (mmu:108100); (R-MMU-2029482); (R-MMU-4420097); (R-MMU-5663213); (R-MMU-9013149); (R-MMU-9013423)", "pathway_count": 6, "publication_count": 21, "publication_id_list": "10.1101/2023.09.13.557529;10814512;11514062;12006592;12884081;15592455;16452087;17115031;17242355;21183079;21750661;22645316;25428506;34678516;35822049;37685917;37730842;37828378;38149472;38724689;40885482", "class_list": "", "function": "A lissencephaly-associated BAIAP2 variant causes defects in neuronal migration during brain development., [RefSeq, PubMed]; Adapter protein that links membrane-bound small G proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth, neuronal differentiation and neuronal migration (PubMed:38149472). Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions., [UniProtKB, PubMed, PubMed]; Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions., [UniProtKB, UniProtKB]; BIN1 regulates actin-membrane interactions during IRSp53-dependent filopodia formation. Publication Status: Online-Only, [RefSeq, PubMed]; Molecular Relay Stations in Membrane Nanotubes: IRSp53 Involved in Actin-Based Force Generation. Publication Status: Online-Only, [RefSeq, PubMed]; The PFC-LH-VTA pathway contributes to social deficits in IRSp53-mutant mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q91V97;Q923V9;Q923W0", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0008093 cytoskeletal anchor activity;GO:0070064 proline-rich region binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005874 microtubule;GO:0005886 plasma membrane", "go_biological_process": "GO:0007009 plasma membrane organization;GO:0010976 positive regulation of neuron projection development;GO:0016358 dendrite development;GO:0032956 regulation of actin cytoskeleton organization;GO:0046847 filopodium assembly", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q8BKX1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z277-1", "uniprot_id": [ { "id": "BAZ1B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z277", "type": "external" } ], "mass": 170651.0, "length": 1479, "protein_name": "Tyrosine-protein kinase BAZ1B", "gene_name": "Baz1b", "organism": "Mouse", "refseq_name": "tyrosine-protein kinase BAZ1B", "refseq_ac": [ { "id": "NP_035844", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035844", "type": "external" } ], "gene_names_uniprotkb": "Baz1b; Wbscr9; Wstf", "gene_names_refseq": "Baz1b; WSTF; Wbscr9", "protein_names_uniprotkb": "Tyrosine-protein kinase BAZ1B; 2.7.10.2; Bromodomain adjacent to zinc finger domain protein 1B; Williams syndrome transcription factor homolog; Williams-Beuren syndrome chromosomal region 9 protein homolog", "protein_names_refseq": "Williams-Beuren syndrome chromosome region 9 homolog; bromodomain adjacent to zinc finger domain protein 1B; bromodomain adjacent to zinc finger domain, 1B; tyrosine-protein kinase BAZ1B; williams syndrome transcription factor homolog; williams-Beuren syndrome chromosomal region 9 protein homolog", "tax_id": 10090, "disease": "Williams-Beuren syndrome (Disease Ontology:DOID:1928)", "pathway": " (mmu:22385); (R-MMU-5250924); (R-MMU-5693565)", "pathway_count": 3, "publication_count": 19, "publication_id_list": "11980720;16514417;17242355;19092802;19144319;21183079;22872234;23806337;25428506;28528544;30084848;31219806;34428180;34887587;35723872;36210013;37827362;39627609;9858827", "class_list": "", "function": "Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator (By similarity). Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph) (PubMed:19092802). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19092802). Regulatory subunit of the ATP-dependent WICH-1 and WICH-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:11980720). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:16514417). The WICH-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the WICH-5 ISWI chromatin remodeling complex (By similarity). The WICH-5 ISWI chromatin remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (PubMed:16514417). Within the B-WICH complex has a role in RNA polymerase III transcription (By similarity). Mediates the recruitment of the WICH-5 ISWI chromatin remodeling complex to replication foci during DNA replication (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Baz1b Dosage Influences Cardiovascular Function, Predisposing to Dilated Cardiomyopathy., [RefSeq, PubMed]; Loss of Baz1b in mice causes perinatal lethality, growth failure, and variable multi-system outcomes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9EJ99;Q3URP5;Q3USR7;Q3UVM2;Q8CAU9;Q9CU68", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.3.1.57", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.57", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" } ], "go_molecular_function": "GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0042393 histone binding;GO:0035173 histone kinase activity", "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000793 condensed chromosome", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0043687 post-translational protein modification;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q9Z277-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99PU7-1", "uniprot_id": [ { "id": "BAP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99PU7", "type": "external" } ], "mass": 80492.0, "length": 728, "protein_name": "Ubiquitin carboxyl-terminal hydrolase BAP1", "gene_name": "Bap1", "organism": "Mouse", "refseq_name": "ubiquitin carboxyl-terminal hydrolase BAP1", "refseq_ac": [ { "id": "NP_081364", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081364", "type": "external" } ], "gene_names_uniprotkb": "Bap1; Kiaa0272", "gene_names_refseq": "2300006C11Rik; Bap1; mKIAA0272; uch-x4", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase BAP1; 3.4.19.12; BRCA1-associated protein 1; UCH-X4; Ubiquitin C-terminal hydrolase X4", "protein_names_refseq": "BRCA1-associated protein 1; ubiquitin C-terminal hydrolase X4; ubiquitin carboxyl-terminal hydrolase BAP1", "tax_id": 10090, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); basal cell carcinoma (Disease Ontology:DOID:2513); extrahepatic bile duct adenocarcinoma (Disease Ontology:DOID:3495); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); uveal melanoma (Disease Ontology:DOID:6039); malignant pleural mesothelioma (Disease Ontology:DOID:7474)", "pathway": " (mmu:104416); (R-MMU-5689603); (R-MMU-5693565)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "18757409;19188440;21183079;21750661;22878500;24928783;29187734;30084848;31219806;32747411;34170818;34428180;34887587;35446349;9528852", "class_list": "", "function": "Bap1 helps to control cell proliferation by regulating HCF-1 protein levels and by associating with genes involved in the G(1)-S transition, [RefSeq, PubMed]; Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1 (By similarity) (PubMed:35446349). Catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-120' (H2AK119ub1) (By similarity) (PubMed:32747411, PubMed:35446349). Does not deubiquitinate monoubiquitinated histone H2B (By similarity). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (By similarity) (PubMed:32747411, PubMed:35446349). Antagonizes PRC1 mediated H2AK119ub1 monoubiquitination (By similarity). As part of the PR-DUB complex, associates with chromatin enriched in histone marks H3K4me1, H3K4me3, and H3K27Ac, but not in H3K27me3 (By similarity) (PubMed:32747411). Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Able to mediate autodeubiquitination via intramolecular interactions to counteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (By similarity). Negatively regulates epithelial-mesenchymal transition (EMT) of trophoblast stem cells during placental development by regulating genes involved in epithelial cell integrity, cell adhesion and cytoskeletal organization (PubMed:34170818)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Drawing parallels to human disease, these unbiased genetic findings indicate that BAP1 mutation carriers are predisposed to the tumorigenic effects of asbestos and suggest that high penetrance of mesothelioma requires such environmental exposure., [RefSeq, PubMed]; Results identify a potent tumor suppressor function for BAP1 in myeloid neoplasia; propose that BAP1 forms a core complex with HCF-1 and OGT that can differentially recruit additional histone-modifying enzymes to regulate gene expression and preserve norm, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TCR6;Q6ZQE6", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.4.1.255", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.255", "type": "external" }, { "id": "1.14.99.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.99.66", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0031490 chromatin DNA binding;GO:0004843 cysteine-type deubiquitinase activity;GO:0140950 histone H2A deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005694 chromosome", "go_biological_process": "GO:0030851 granulocyte differentiation;GO:0030223 neutrophil differentiation;GO:0043249 erythrocyte maturation;GO:0000278 mitotic cell cycle;GO:0001701 in utero embryonic development", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q99PU7-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C1Z7-1", "uniprot_id": [ { "id": "BBS4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C1Z7", "type": "external" } ], "mass": 58255.0, "length": 520, "protein_name": "BBSome complex member BBS4", "gene_name": "Bbs4", "organism": "Mouse", "refseq_name": "BBSome complex member BBS4 isoform 1", "refseq_ac": [ { "id": "NP_780534", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780534", "type": "external" } ], "gene_names_uniprotkb": "Bbs4", "gene_names_refseq": "Bbs4; D9Ertd464e", "protein_names_uniprotkb": "BBSome complex member BBS4; Bardet-Biedl syndrome 4 protein homolog", "protein_names_refseq": "BBSome complex member BBS4 isoform 1; BBSome complex member BBS4; Bardet-Biedl syndrome 4 homolog; bardet-Biedl syndrome 4 protein homolog", "tax_id": 10090, "disease": "ciliopathy (Disease Ontology:DOID:0060340); Bardet-Biedl syndrome 4 (Disease Ontology:DOID:0110126); morbid obesity (Disease Ontology:DOID:11981); Bardet-Biedl syndrome (Disease Ontology:DOID:1935); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:102774); (R-MMU-5620922)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "12016587;15107855;15173597;15322545;18317593;21750661;22072986;23943788;24469809;25428506;30084848;30779550;34428180", "class_list": "", "function": "Bbs4-null mice develop both motile and primary cilia, demonstrating that Bbs4 is not required for global cilia formation., [RefSeq, PubMed]; Deletions of Bbs1 or Bbs4 affected the olfactory epithelium, causing severe reduction of the ciliated border, disorganization of the dendritic microtubule network and trapping of olfactory ciliary proteins in dendrites and cell bodies., [RefSeq, PubMed]; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization. Required for microtubule anchoring at the centrosome but not for microtubule nucleation. May be required for the dynein-mediated transport of pericentriolar proteins to the centrosome (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UYF0;Q562E1;Q5EBJ7;Q8CA57", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0048487 beta-tubulin binding;GO:0043014 alpha-tubulin binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0034452 dynactin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005929 cilium;GO:0016020 membrane", "go_biological_process": "GO:0002260 lymphocyte homeostasis;GO:0010629 negative regulation of gene expression;GO:0015031 protein transport;GO:0016358 dendrite development;GO:0030534 adult behavior", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8C1Z7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JM96-1", "uniprot_id": [ { "id": "BORG4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JM96", "type": "external" } ], "mass": 37869.0, "length": 349, "protein_name": "Cdc42 effector protein 4", "gene_name": "Cdc42ep4", "organism": "Mouse", "refseq_name": "cdc42 effector protein 4", "refseq_ac": [ { "id": "NP_001156818", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156818", "type": "external" } ], "gene_names_uniprotkb": "Cdc42ep4; Borg4; Cep4", "gene_names_refseq": "1500041M20Rik; Borg4; CEP4; Cdc42ep4", "protein_names_uniprotkb": "Cdc42 effector protein 4; Binder of Rho GTPases 4", "protein_names_refseq": "CDC42 effector protein (Rho GTPase binding) 4; binder of Rho GTPase 4; binder of Rho GTPases 4; cdc42 effector protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:56699); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013406)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "10490598;11185749;17114649;17242355;19144319;21183079;21750661;25428506;30084848;30779550;34428180;35169866", "class_list": "", "function": "Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts., [UniProtKB]; Regulation of dendrite growth by Cdc42 effector protein4 in hippocampal neurons in vitro., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TNF3;Q9QZT8", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0007266 Rho protein signal transduction;GO:0008360 regulation of cell shape;GO:0031274 positive regulation of pseudopodium assembly;GO:0071346 cellular response to type II interferon;GO:0030838 positive regulation of actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9JM96-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35991-1", "uniprot_id": [ { "id": "BTK_MOUSE", "url": "https://www.uniprot.org/uniprot/P35991", "type": "external" } ], "mass": 76437.0, "length": 659, "protein_name": "Tyrosine-protein kinase BTK", "gene_name": "Btk", "organism": "Mouse", "refseq_name": "tyrosine-protein kinase BTK", "refseq_ac": [ { "id": "NP_038510", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038510", "type": "external" } ], "gene_names_uniprotkb": "Btk; Bpk", "gene_names_refseq": "Btk; xid", "protein_names_uniprotkb": "Tyrosine-protein kinase BTK; 2.7.10.2; ATK; Agammaglobulinemia tyrosine kinase; B-cell progenitor kinase; BPK; Bruton tyrosine kinase; Kinase EMB", "protein_names_refseq": "ATK; B-cell progenitor kinase; BPK; Bruton's tyrosine kinase; Tyrosine-protein kinase BTK (Brutons tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB); X-linked immune deficiency; agammaglobulinaemia tyrosine kinase; agammaglobulinemia tyrosine kinase; bruton tyrosine kinase; kinase EMB; tyrosine-protein kinase BTK", "tax_id": 10090, "disease": "mantle cell lymphoma (Disease Ontology:DOID:0050746); isolated growth hormone deficiency type III (Disease Ontology:DOID:0060875); COVID-19 (Disease Ontology:DOID:0080600); X-linked agammaglobulinemia (Disease Ontology:DOID:14179); arthus reaction (Disease Ontology:DOID:1556); agammaglobulinemia (Disease Ontology:DOID:2583); central nervous system lymphoma (Disease Ontology:DOID:3234); lung adenocarcinoma (Disease Ontology:DOID:3910); B-cell lymphoma (Disease Ontology:DOID:707); Burkitt lymphoma (Disease Ontology:DOID:8584); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:12229); (R-MMU-2029482); (R-MMU-2424491); (R-MMU-2871809); (R-MMU-416476); (R-MMU-416482); (R-MMU-5663213); (R-MMU-8964315); (R-MMU-983695)", "pathway_count": 9, "publication_count": 41, "publication_id_list": "10811867;10852954;11120822;14634110;16738337;17725607;17947660;19290921;21750661;23478294;23544144;26059659;28359287;28368423;29069762;29263930;29348675;30084848;30635655;30646846;30779550;31552054;33162995;33639170;34428180;34554188;37507081;38365047;38507738;39259208;7538439;7626884;7989760;8332901;8425221;8476425;8629002;8630736;9240435;9326643;9751072", "class_list": "", "function": "Bruton Tyrosine Kinase Inhibition Decreases Inflammation and Differentially Impacts Phagocytosis and Cellular Metabolism in Mouse- and Human-derived Myeloid Cells., [RefSeq, PubMed]; Bruton's tyrosine kinase ablation inhibits B cell responses and antibody production for the prevention of chronic rejection in cardiac transplantation., [RefSeq, PubMed]; In BTK, phosphorylated Y223 in the SH3 domain mirrors catalytic activity, but does not influence biological function., [RefSeq, PubMed]; Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling (PubMed:10852954, PubMed:7538439, PubMed:8629002). Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (By similarity). After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members (By similarity). PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK (By similarity). BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways (By similarity). Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway (PubMed:17725607). The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense (By similarity). Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells (By similarity). Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation (By similarity). BTK also plays a critical role in transcription regulation (By similarity). Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes (By similarity). BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B (By similarity). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (PubMed:34554188). Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR (PubMed:11120822, PubMed:16738337). GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression (PubMed:11120822, PubMed:16738337). ARID3A and NFAT are other transcriptional target of BTK (PubMed:11120822, PubMed:16738337). BTK is required for the formation of functional ARID3A DNA-binding complexes (PubMed:11120822, PubMed:16738337). There is however no evidence that BTK itself binds directly to DNA (PubMed:11120822, PubMed:16738337). BTK has a dual role in the regulation of apoptosis (By similarity). Plays a role in STING1-mediated induction of type I interferon (IFN) response by phosphorylating DDX41 (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 15, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 11, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q61365", "ec_number_list": [ { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" } ], "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0045121 membrane raft", "go_biological_process": "GO:0032693 negative regulation of interleukin-10 production;GO:0006351 DNA-templated transcription;GO:0006468 protein phosphorylation;GO:0018108 peptidyl-tyrosine phosphorylation;GO:0032496 response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 4.4, "record_id": "P35991-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36895-1", "uniprot_id": [ { "id": "BMR1A_MOUSE", "url": "https://www.uniprot.org/uniprot/P36895", "type": "external" } ], "mass": 60063.0, "length": 532, "protein_name": "Bone morphogenetic protein receptor type-1A", "gene_name": "Bmpr1a", "organism": "Mouse", "refseq_name": "bone morphogenetic protein receptor type-1A precursor", "refseq_ac": [ { "id": "NP_033888", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033888", "type": "external" } ], "gene_names_uniprotkb": "Bmpr1a; Acvrlk3; Bmpr", "gene_names_refseq": "1110037I22Rik; ALK-3; ALK3; BMPR-1A; BMPR-IA; Bmpr1a; Bmpr; SKR5", "protein_names_uniprotkb": "Bone morphogenetic protein receptor type-1A; 2.7.11.30; ALK-3; Activin receptor-like kinase 3; BMP type-1A receptor; BMP-2/BMP-4 receptor; BMPR-1A; SKR5; Serine/threonine-protein kinase receptor R5", "protein_names_refseq": "BMP type-1A receptor; BMP-2/BMP-4 receptor; activin receptor-like kinase 3; bone morphogenetic protein receptor type-1A precursor; serine/threonine-protein kinase receptor R5", "tax_id": 10090, "disease": "juvenile polyposis syndrome (Disease Ontology:DOID:0050787); chromosome 10q23 deletion syndrome (Disease Ontology:DOID:0060389); hereditary mixed polyposis syndrome 2 (Disease Ontology:DOID:0111686); Ebstein anomaly (Disease Ontology:DOID:14289); hamartoma (Disease Ontology:DOID:3462); Wolff-Parkinson-White syndrome (Disease Ontology:DOID:384); intestinal disease (Disease Ontology:DOID:5295); pulmonary hypertension (Disease Ontology:DOID:6432); osteoarthritis (Disease Ontology:DOID:8398)", "pathway": " (mmu:12166); (R-MMU-201451)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "21750661;23527555;24098149;29415997;31599954;31800957;37828378;38719881;38856718;7750489;7937936;8065329", "class_list": "", "function": "Defective mesenchymal Bmpr1a-mediated BMP signaling causes congenital pulmonary cysts. Publication Status: Online-Only, [RefSeq, PubMed]; Hyperthyroidism-driven bone loss depends on BMP receptor Bmpr1a expression in osteoblasts. Publication Status: Online-Only, [RefSeq, PubMed]; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction (PubMed:24098149). Mediates induction of adipogenesis by GDF6 (PubMed:23527555). May promote the expression of HAMP, potentially via its interaction with BMP2 (PubMed:31800957)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.11.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.30", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0005025 transforming growth factor beta receptor activity, type I", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0043235 receptor complex", "go_biological_process": "GO:0003171 atrioventricular valve development;GO:0001525 angiogenesis;GO:0001701 in utero embryonic development;GO:0006955 immune response;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P36895-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35914-1", "uniprot_id": [ { "id": "BNC1_MOUSE", "url": "https://www.uniprot.org/uniprot/O35914", "type": "external" } ], "mass": 106659.0, "length": 961, "protein_name": "Zinc finger protein basonuclin-1", "gene_name": "Bnc1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Bnc1; Bnc", "gene_names_refseq": "", "protein_names_uniprotkb": "Zinc finger protein basonuclin-1", "protein_names_refseq": "", "tax_id": 10090, "disease": "primary ovarian insufficiency 16 (Disease Ontology:DOID:0080873)", "pathway": " (mmu:12173)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;22266914;23707421;9300825;9687312", "class_list": "", "function": "Transcriptional activator (PubMed:23707421, PubMed:9687312). It is likely involved in the regulation of keratinocytes terminal differentiation in squamous epithelia and hair follicles (By similarity). Required for the maintenance of spermatogenesis (PubMed:22266914). It is involved in the positive regulation of oocyte maturation, probably acting through the control of BMP15 levels and regulation of AKT signaling cascade (By similarity). May also play a role in the early development of embryos (PubMed:9687312)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Transcriptional activator. It is likely involved in the regulation of keratinocytes terminal differentiation in squamous epithelia and hair follicles. Required for the maintenance of spermatogenesis. It is involved in the positive regulation of oocyte maturation, probably acting through the control of BMP15 levels and regulation of AKT signaling cascade. May also play a role in the early development of embryos., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O54886", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000182 rDNA binding;GO:0001216 DNA-binding transcription activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0042060 wound healing", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O35914-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21275-1", "uniprot_id": [ { "id": "BMP4_MOUSE", "url": "https://www.uniprot.org/uniprot/P21275", "type": "external" } ], "mass": 46497.0, "length": 408, "protein_name": "Bone morphogenetic protein 4", "gene_name": "Bmp4", "organism": "Mouse", "refseq_name": "bone morphogenetic protein 4 preproprotein", "refseq_ac": [ { "id": "NP_001303289", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001303289", "type": "external" } ], "gene_names_uniprotkb": "Bmp4; Bmp-4; Dvr-4", "gene_names_refseq": "Bmp-4; Bmp2b-1; Bmp2b1; Bmp2b; Bmp4", "protein_names_uniprotkb": "Bone morphogenetic protein 4; BMP-2B; BMP-4; Bone morphogenetic protein 2B", "protein_names_refseq": "bone morphogenetic protein 2B; bone morphogenetic protein 4 preproprotein", "tax_id": 10090, "disease": "tooth agenesis (Disease Ontology:DOID:0050591); atrioventricular septal defect (Disease Ontology:DOID:0050651); juvenile polyposis syndrome (Disease Ontology:DOID:0050787); stroke (Disease Ontology:DOID:0051061); ossification of the posterior longitudinal ligament of spine (Disease Ontology:DOID:0060887); physical disorder (Disease Ontology:DOID:0080015); congenital anomalies of the kidney and urinary tract (Disease Ontology:DOID:0080205); congenital anomalies of the kidney and urinary tract 2 (Disease Ontology:DOID:0080207); cleft palate-lateral synechia syndrome (Disease Ontology:DOID:0080313); orofacial cleft 11 (Disease Ontology:DOID:0080404); Axenfeld-Rieger syndrome type 3 (Disease Ontology:DOID:0110122); progressive osseous heteroplasia (Disease Ontology:DOID:0111535); syndromic microphthalmia 6 (Disease Ontology:DOID:0111805); keratoconus (Disease Ontology:DOID:10126); prostate carcinoma (Disease Ontology:DOID:10286); esophagitis (Disease Ontology:DOID:11963); otosclerosis (Disease Ontology:DOID:12185); cartilage disease (Disease Ontology:DOID:1222); fibrodysplasia ossificans progressiva (Disease Ontology:DOID:13374); tuberous sclerosis (Disease Ontology:DOID:13515); peptic esophagitis (Disease Ontology:DOID:13976); Marfan syndrome (Disease Ontology:DOID:14323); breast cancer (Disease Ontology:DOID:1612); urinary system disease (Disease Ontology:DOID:18); calcinosis (Disease Ontology:DOID:182); epilepsy (Disease Ontology:DOID:1826); atrial heart septal defect (Disease Ontology:DOID:1882); melanoma (Disease Ontology:DOID:1909); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); macular degeneration (Disease Ontology:DOID:4448); renal cell carcinoma (Disease Ontology:DOID:4450); prolactinoma (Disease Ontology:DOID:5394); strabismus (Disease Ontology:DOID:540); myositis ossificans (Disease Ontology:DOID:668); Barrett's esophagus (Disease Ontology:DOID:9206); cleft lip (Disease Ontology:DOID:9296)", "pathway": " (mmu:12159); (R-MMU-2129379); (R-MMU-381426); (R-MMU-8957275)", "pathway_count": 4, "publication_count": 24, "publication_id_list": "10049358;11260715;14623234;14973287;15039429;15206957;15671031;15975920;16604073;17301089;17472960;1970330;23702483;24028588;27713059;29148101;30084848;32127020;34428180;34995814;7499338;8358941;8507180;8898217", "class_list": "glycogene", "function": "Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including neurogenesis, vascular development, angiogenesis and osteogenesis (PubMed:10049358, PubMed:14973287, PubMed:15206957). Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (PubMed:17301089). Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Positively regulates the expression of odontogenic development regulator MSX1 via inducing the IPO7-mediated import of SMAD1 to the nucleus (PubMed:34995814). Required for MSX1-mediated mesenchymal molar tooth bud development beyond the bud stage, via promoting Wnt signaling (PubMed:27713059, PubMed:8898217). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling (PubMed:29148101). Able to induce its own expression in dental mesenchymal cells and also in the neighboring dental epithelial cells via an MSX1-mediated pathway (PubMed:8898217). Can also signal through non-canonical BMP pathways such as ERK/MAP kinase, PI3K/Akt or SRC cascades. For example, induces SRC phosphorylation which, in turn, activates VEGFR2, leading to an angiogenic response (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Homozygous knockout mice die in utero, while a conditional knockout mouse exhibits defects in heart development. Transgenic mice overexpressing this gene in a neuron-specific manner exhibit a phenotype resembling the rare hereditary connective tissue disease, fibrodysplasia ossificans progressiva. [provided by RefSeq, Jul 2016]., [RefSeq]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 31, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 36, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0042056 chemoattractant activity;GO:0042802 identical protein binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031982 vesicle", "go_biological_process": "GO:0001759 organ induction;GO:0060429 epithelium development;GO:1901331 positive regulation of odontoblast differentiation;GO:1901341 positive regulation of store-operated calcium channel activity;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P21275-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010001.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23359-1", "uniprot_id": [ { "id": "BMP7_MOUSE", "url": "https://www.uniprot.org/uniprot/P23359", "type": "external" } ], "mass": 49199.0, "length": 430, "protein_name": "Bone morphogenetic protein 7", "gene_name": "Bmp7", "organism": "Mouse", "refseq_name": "bone morphogenetic protein 7 preproprotein", "refseq_ac": [ { "id": "NP_031583", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031583", "type": "external" } ], "gene_names_uniprotkb": "Bmp7; Bmp-7; Op1", "gene_names_refseq": "Bmp7; OP1", "protein_names_uniprotkb": "Bone morphogenetic protein 7; BMP-7; OP-1; Osteogenic protein 1", "protein_names_refseq": "bone morphogenetic protein 7 preproprotein; osteogenic protein 1", "tax_id": 10090, "disease": "obstructive sleep apnea (Disease Ontology:DOID:0050848); prostate cancer (Disease Ontology:DOID:10283); pyelonephritis (Disease Ontology:DOID:11400); acute kidney tubular necrosis (Disease Ontology:DOID:12556); Marfan syndrome (Disease Ontology:DOID:14323); breast cancer (Disease Ontology:DOID:1612); nephroblastoma (Disease Ontology:DOID:2154); ovarian carcinoma (Disease Ontology:DOID:4001); renal cell carcinoma (Disease Ontology:DOID:4450); kidney disease (Disease Ontology:DOID:557); osteoarthritis (Disease Ontology:DOID:8398); diabetes mellitus (Disease Ontology:DOID:9351); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:12162); (R-MMU-2129379)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;14623234;15843411;1715687;22461901;30097509;30779550;34428180;35820727;38678558;9013703", "class_list": "", "function": "BMP7 promotes cardiomyocyte regeneration in zebrafish and adult mice., [RefSeq, PubMed]; Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including embryogenesis, hematopoiesis, neurogenesis and skeletal morphogenesis (PubMed:22461901, PubMed:9013703). Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2A. Once all three components are bound together in a complex at the cell surface, ACVR2A phosphorylates and activates ACVR1. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. For specific functions such as growth cone collapse in developing spinal neurons and chemotaxis of monocytes, also uses BMPR2 as type II receptor. Can also signal through non-canonical pathways such as P38 MAP kinase signaling cascade that promotes brown adipocyte differentiation through activation of target genes, including members of the SOX family of transcription factors (By similarity). Promotes the expression of HAMP, this is repressed by its interaction with ERFE (PubMed:30097509)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. Mutation of this gene results in skeletal, kidney, and other developmental defects. [provided by RefSeq, Jul 2016]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 2, "disease_count": 13, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q91XF7", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity;GO:0043539 protein serine/threonine kinase activator activity;GO:0070700 BMP receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0031982 vesicle", "go_biological_process": "GO:0007507 heart development;GO:0008285 negative regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0030855 epithelial cell differentiation;GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P23359-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35564-1", "uniprot_id": [ { "id": "CALX_MOUSE", "url": "https://www.uniprot.org/uniprot/P35564", "type": "external" } ], "mass": 67278.0, "length": 591, "protein_name": "Calnexin", "gene_name": "Canx", "organism": "Mouse", "refseq_name": "calnexin precursor", "refseq_ac": [ { "id": "NP_001103969", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103969", "type": "external" } ], "gene_names_uniprotkb": "Canx", "gene_names_refseq": "1110069N15Rik; Canx; Cnx; D11Ertd153e", "protein_names_uniprotkb": "Calnexin", "protein_names_refseq": "calnexin precursor", "tax_id": 10090, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:12330); (R-MMU-2132295); (R-MMU-8984722); (R-MMU-901042); (R-MMU-9020956); (R-MMU-9768727); (R-MMU-983170)", "pathway_count": 7, "publication_count": 22, "publication_id_list": "10.1101/2023.09.13.557529;17114649;17208939;17622165;18630941;19131326;19144319;20945367;21183079;21747946;22645316;29237092;32783947;34428180;36288343;37453647;37507081;37828378;39627609;7628443;8136357;8148318", "class_list": "glycogene", "function": "Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 31, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0034185 apolipoprotein binding;GO:0051082 unfolded protein binding;GO:0005509 calcium ion binding;GO:0030246 carbohydrate binding;GO:0035255 ionotropic glutamate receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005783 endoplasmic reticulum;GO:0005790 smooth endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0006457 protein folding;GO:0072583 clathrin-dependent endocytosis;GO:0036503 ERAD pathway;GO:0048488 synaptic vesicle endocytosis", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P35564-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UW26-1", "uniprot_id": [ { "id": "BSPH1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UW26", "type": "external" } ], "mass": 16014.0, "length": 133, "protein_name": "Binder of sperm protein homolog 1", "gene_name": "Bsph1", "organism": "Mouse", "refseq_name": "binder of sperm protein homolog 1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001028590", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028590", "type": "external" } ], "gene_names_uniprotkb": "Bsph1; Gm767", "gene_names_refseq": "Bsph1; Gm767", "protein_names_uniprotkb": "Binder of sperm protein homolog 1; Bovine seminal plasma protein homolog 1; Bovine seminal plasma protein-like 1", "protein_names_refseq": "binder of sperm protein homolog 1 isoform 1 precursor; bovine seminal plasma protein homolog 1; bovine seminal plasma protein-like 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:330470)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17085770;17307309;22539676;24307707;25602034;32253033;32488144", "class_list": "", "function": "Binds sperm in vitro and promotes sperm capacitation (PubMed:22539676, PubMed:24307707). Specifically promotes capacitation induced by high density lipoproteins (HDLs) (PubMed:25602034). Also binds heparin, phospholipid liposomes, and weakly to gelatin (PubMed:22539676). Does not bind chondroitin sulfate B (PubMed:22539676)., [UniProtKB, PubMed, PubMed, PubMed]; Both native BSPH1 and recombinant-BSPH1 were detected on the head and the midpiece region of sperm, although a stronger signal was detected on the midpiece region when sperm were incubated in a capacitating media. Publication Status: Online-Only, [RefSeq, PubMed]; Epididymal proteins Binder of SPerm Homologs 1 and 2 (BSPH1/2) are dispensable for male fertility and sperm motility in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Role of Binder of SPerm homolog 1 (BSPH1) protein in mouse sperm-egg interaction and fertilization., [RefSeq, PubMed]; Sperm-binding fibronectin type II-module proteins are genetically linked and functionally related., [RefSeq, PubMed]; This gene encodes a member of the binder of sperm family. The encoded protein may be involved in sperm capacitation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RVZ6", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface", "go_biological_process": "GO:0007338 single fertilization;GO:0048240 sperm capacitation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q3UW26-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3V3N7-1", "uniprot_id": [ { "id": "BBS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3V3N7", "type": "external" } ], "mass": 65094.0, "length": 593, "protein_name": "BBSome complex member BBS1", "gene_name": "Bbs1", "organism": "Mouse", "refseq_name": "BBSome complex member BBS1", "refseq_ac": [ { "id": "NP_001028300", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028300", "type": "external" } ], "gene_names_uniprotkb": "Bbs1", "gene_names_refseq": "Bbs1; D19Ertd609e", "protein_names_uniprotkb": "BBSome complex member BBS1; Bardet-Biedl syndrome 1 protein homolog", "protein_names_refseq": "BBSome complex member BBS1; Bardet-Biedl syndrome 1 homolog; Bardet-Biedl syndrome 1 protein homolog", "tax_id": 10090, "disease": "Bardet-Biedl syndrome 1 (Disease Ontology:DOID:0110123); Bardet-Biedl syndrome (Disease Ontology:DOID:1935); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:52028); (R-MMU-5620922)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;15322545;18032602;21750661;28237838;34428180", "class_list": "", "function": "Deletions of Bbs1 or Bbs4 affected the olfactory epithelium, causing severe reduction of the ciliated border, disorganization of the dendritic microtubule network and trapping of olfactory ciliary proteins in dendrites and cell bodies., [RefSeq, PubMed]; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly (By similarity). Plays a role in olfactory cilium biogenesis/maintenance and trafficking and is essential for the localization of the BBSome complex in the olfactory sensory neurons cilia (PubMed:15322545, PubMed:28237838)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0051219 phosphoprotein binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0005113 patched binding;GO:0005119 smoothened binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005929 cilium;GO:0031514 motile cilium;GO:0005930 axoneme;GO:0034451 centriolar satellite", "go_biological_process": "GO:0042048 olfactory behavior;GO:0006629 lipid metabolic process;GO:0009566 fertilization;GO:0016358 dendrite development;GO:0030534 adult behavior", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q3V3N7-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K2G4-1", "uniprot_id": [ { "id": "BBS7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K2G4", "type": "external" } ], "mass": 80320.0, "length": 715, "protein_name": "BBSome complex member BBS7", "gene_name": "Bbs7", "organism": "Mouse", "refseq_name": "BBSome complex member BBS7", "refseq_ac": [ { "id": "NP_082086", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082086", "type": "external" } ], "gene_names_uniprotkb": "Bbs7; Bbs2l1", "gene_names_refseq": "8430406N16Rik; Bbs7", "protein_names_uniprotkb": "BBSome complex member BBS7; BBS2-like protein 1; Bardet-Biedl syndrome 7 protein homolog", "protein_names_refseq": "BBS2-like protein 1; BBSome complex member BBS7; bardet-Biedl syndrome 7 protein homolog", "tax_id": 10090, "disease": "Bardet-Biedl syndrome 7 (Disease Ontology:DOID:0110129); Bardet-Biedl syndrome (Disease Ontology:DOID:1935)", "pathway": " (mmu:71492); (R-MMU-5620922)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "12567324;21750661;22072986;23807208;25428506;34428180;34910225", "class_list": "", "function": "A deletion containing a CTCF-element in intron 8 of the Bbs7 gene is partially responsible for juvenile obesity in the Berlin Fat Mouse., [RefSeq, PubMed]; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C7G3;Q8CH00;Q9CXC2", "ec_number_list": [], "go_molecular_function": "GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0016020 membrane;GO:0043005 neuron projection;GO:0005930 axoneme", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0007507 heart development;GO:0015031 protein transport;GO:0007420 brain development;GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8K2G4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CWI3-1", "uniprot_id": [ { "id": "BCCIP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CWI3", "type": "external" } ], "mass": 35942.0, "length": 316, "protein_name": "BRCA2 and CDKN1A-interacting protein", "gene_name": "Bccip", "organism": "Mouse", "refseq_name": "BRCA2 and CDKN1A-interacting protein", "refseq_ac": [ { "id": "NP_079668", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079668", "type": "external" } ], "gene_names_uniprotkb": "Bccip", "gene_names_refseq": "1110013J05Rik; Bccip; TOK-1", "protein_names_uniprotkb": "BRCA2 and CDKN1A-interacting protein", "protein_names_refseq": "BRCA2 and CDKN1A-interacting protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:66165)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;18299400;21183079;21966279;22292003;24145349;25428506;26495903;28394342;30084848;33039352;33245766;34428180;35547804", "class_list": "", "function": "BCCIP and its anti-replication stress functions are essential for normal neural development by maintaining an orderly proliferation of neural progenitors., [RefSeq, PubMed]; BCCIP is required for nucleolar recruitment of eIF6 and 12S pre-rRNA production during 60S ribosome biogenesis., [RefSeq, PubMed]; BCCIP represents a paradoxical class of modulators for tumorigenesis as a suppressor for initiation but a requisite for progression., [RefSeq, PubMed]; During interphase, required for microtubule organizing and anchoring activities. During mitosis, required for the organization and stabilization of the spindle pole (PubMed:28394342). May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ) (By similarity)., [UniProtKB, PubMed, UniProtKB]; Requirement of Bccip for the Regeneration of Intestinal Progenitors., [RefSeq, PubMed]; These data suggest a unique function of BCCIP, not only in repair of DNA damage, but also in resolving stalled replication forks and prevention of replication stress, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9D1E0", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0042802 identical protein binding;GO:0015631 tubulin binding;GO:0019207 kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005814 centriole", "go_biological_process": "GO:0006281 DNA repair;GO:0090307 mitotic spindle assembly;GO:0006974 DNA damage response;GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9CWI3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DBJ3-1", "uniprot_id": [ { "id": "BI2L1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DBJ3", "type": "external" } ], "mass": 57188.0, "length": 514, "protein_name": "BAR/IMD domain-containing adapter protein 2-like 1", "gene_name": "Baiap2l1", "organism": "Mouse", "refseq_name": "BAR/IMD domain-containing adapter protein 2-like 1", "refseq_ac": [ { "id": "NP_080109", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080109", "type": "external" } ], "gene_names_uniprotkb": "Baiap2l1; Irtks", "gene_names_refseq": "1300006M19Rik; Baiap2l1; IRTKS", "protein_names_uniprotkb": "BAR/IMD domain-containing adapter protein 2-like 1; BAI1-associated protein 2-like protein 1; Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1; Insulin receptor tyrosine kinase substrate", "protein_names_refseq": "BAI1-associated protein 2-like protein 1; BAR/IMD domain-containing adapter protein 2-like 1; brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1; insulin receptor tyrosine kinase substrate", "tax_id": 10090, "disease": "", "pathway": " (mmu:66898); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013423); (R-MMU-9035034)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "17242355;17430976;21183079;23896986;26348439;27278019;28067313;30197089;34428180;39093051;39192031", "class_list": "", "function": "BAIAP2L1 and BAIAP2L2 differently regulate hair cell stereocilia morphology., [RefSeq, PubMed]; Double knockout of IRSp53 and its closest family member, IRTKS, resulted in exacerbated placental abnormalities, particularly in spongiotrophoblast differentiation and development, giving rise to complete embryonic lethality. Publication Status: Online-Only, [RefSeq, PubMed]; Heterochromatin formation and remodeling by IRTKS condensates counteract cellular senescence., [RefSeq, PubMed]; IRTKS functions as a negative modulator of excessive inflammation in viral infections. Publication Status: Online-Only, [RefSeq, PubMed]; IRTKS localizes to the distal tips of actively growing microvilli via a mechanism that requires its N-terminal I-BAR domain. At microvillar tips, IRTKS promotes elongation through a mechanism involving its C-terminal actin-binding WH2 domain., [RefSeq, PubMed]; May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection (By similarity)., [UniProtKB]; Rho family GTPases use the I-BAR proteins, IRSp53 (also known as BAIAP2), IRTKS and Pinkbar, as a central mechanism to modulate cell morphology., [RefSeq, PubMed]; The IRTKS, as an adaptor of the insulin receptor (IR), modulates IR-IRS1-PI3K-AKT signaling via regulating the phosphorylation of IR., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0070064 proline-rich region binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0007009 plasma membrane organization;GO:0032956 regulation of actin cytoskeleton organization;GO:0051017 actin filament bundle assembly;GO:0051764 actin crosslink formation;GO:0030838 positive regulation of actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9DBJ3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JLV1-1", "uniprot_id": [ { "id": "BAG3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JLV1", "type": "external" } ], "mass": 61860.0, "length": 577, "protein_name": "BAG family molecular chaperone regulator 3", "gene_name": "Bag3", "organism": "Mouse", "refseq_name": "BAG family molecular chaperone regulator 3", "refseq_ac": [ { "id": "NP_038891", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038891", "type": "external" } ], "gene_names_uniprotkb": "Bag3; Bis; MNCb-2243", "gene_names_refseq": "Bag3; Bis; mg638", "protein_names_uniprotkb": "BAG family molecular chaperone regulator 3; BAG-3; Bcl-2-associated athanogene 3; Bcl-2-binding protein Bis", "protein_names_refseq": "BAG family molecular chaperone regulator 3; BAG-3; Bcl-2-binding protein Bis; Bcl-2-interacting death suppressor; bcl-2-associated athanogene 3", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); autosomal dominant distal hereditary motor neuronopathy 15 (Disease Ontology:DOID:0051042); Charcot-Marie-Tooth disease axonal type 2JJ (Disease Ontology:DOID:0051043); myofibrillar myopathy 6 (Disease Ontology:DOID:0080097); dilated cardiomyopathy 1HH (Disease Ontology:DOID:0110448); dilated cardiomyopathy (Disease Ontology:DOID:12930); pancreatic cancer (Disease Ontology:DOID:1793); glioblastoma (Disease Ontology:DOID:3068)", "pathway": " (mmu:29810); (R-MMU-3371453)", "pathway_count": 2, "publication_count": 23, "publication_id_list": "10.1101/2023.09.13.557529;10597216;16936253;17242355;20060297;21183079;22645316;24129315;25153642;26495903;28135057;28528544;30016717;30059200;31219806;32782141;34428180;36288343;36852467;37899687;38664681;40021952;40885482", "class_list": "", "function": "BAG3 is not required for muscle development, this co-chaperone appears to be critically important for maintenance of mature skeletal muscle., [RefSeq, PubMed]; BAG3 promotes proliferation and migration of arterial smooth muscle cells by regulating STAT3 phosphorylation in diabetic vascular remodeling. Publication Status: Online-Only, [RefSeq, PubMed]; BAG3 regulates the specificity of the recognition of specific MAPT species by NBR1 and SQSTM1., [RefSeq, PubMed]; Co-chaperone and adapter protein that connects different classes of molecular chaperones including heat shock proteins 70 (HSP70s), e.g. HSPA1A/HSP70 or HSPA8/HSC70, and small heat shock proteins (sHSPs), e.g. HSPB8. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from HSP70s, thereby triggering client protein release. Nucleotide release is mediated via BAG3 binding to the nucleotide-binding domain (NBD) of HSP70s, whereas client release is mediated via its binding to the substrate-binding domain (SBD). Has anti-apoptotic activity. Plays a role in the HSF1 nucleocytoplasmic transport., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 15, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 15, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 15, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 8, "glyco_site_count": 16, "binding_glycan_count": 0, "secondary_ac_list": "Q9CQL3;Q9JJC7", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0051087 protein-folding chaperone binding;GO:0044877 protein-containing complex binding;GO:0000774 adenyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0061684 chaperone-mediated autophagy;GO:0000045 autophagosome assembly;GO:0021510 spinal cord development;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 4.2, "record_id": "Q9JLV1-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZK2-1", "uniprot_id": [ { "id": "BCAR3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QZK2", "type": "external" } ], "mass": 92263.0, "length": 820, "protein_name": "Breast cancer anti-estrogen resistance protein 3 homolog", "gene_name": "Bcar3", "organism": "Mouse", "refseq_name": "breast cancer anti-estrogen resistance protein 3 homolog isoform 1", "refseq_ac": [ { "id": "NP_038895", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038895", "type": "external" } ], "gene_names_uniprotkb": "Bcar3; And34", "gene_names_refseq": "AND-34; Bcar3", "protein_names_uniprotkb": "Breast cancer anti-estrogen resistance protein 3 homolog; p130Cas-binding protein AND-34", "protein_names_refseq": "breast cancer anti-estrogen resistance protein 3 homolog isoform 1; breast cancer anti-estrogen resistance protein 3 homolog; p130Cas-binding protein AND-34", "tax_id": 10090, "disease": "", "pathway": " (mmu:29815)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;10438950;10896938;12517963;19103205;19365570;21183079;21750661;21913724;22801373;25499443;27364350;30084848;30779550;31219806;34428180;36210013;38414524", "class_list": "", "function": "AND-34-mediated signaling is required for maintenance of the structural integrity of the adult ocular lens., [RefSeq, PubMed]; Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers (PubMed:12517963). Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis (By similarity). Promotes insulin-mediated membrane ruffling (By similarity). In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1 (PubMed:10896938). Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity (PubMed:25499443). May inhibit TGFB-SMAD signaling, via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction (PubMed:25499443). Regulates EGF-induced DNA synthesis (By similarity). Required for the maintenance of ocular lens morphology and structural integrity, potentially via regulation of focal adhesion complex signaling (PubMed:19365570). Acts upstream of PTPRA to regulate the localization of BCAR1 and PTPRA to focal adhesions, via regulation of SRC-mediated phosphorylation of PTPRA (PubMed:22801373). Positively regulates integrin-induced tyrosine phosphorylation of BCAR1 (PubMed:22801373). Acts as a guanine nucleotide exchange factor (GEF) for small GTPases RALA, RAP1A and RRAS (PubMed:10896938). However, in a contrasting study, lacks GEF activity towards RAP1 (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Localized Administration of Bcar3 siRNA via Nano-Self-Assembly to Treat Idiopathic Pulmonary Fibrosis by Disrupting Macrophage-Fibroblast Crosstalk. Publication Status: Online-Only, [RefSeq, PubMed]; P130Cas- and HEF1-associated AND-34 may regulate B cell adhesion and motility through a Cdc42-mediated signaling pathway., [RefSeq, PubMed]; Study presents a pluridisciplinary approach, including small-angle X-ray scattering, that provides first insights into the structure of the complex formed between BCAR3 and human enhancer of filamentation 1 (HEF1), [RefSeq, PubMed]; The first spontaneous mutation in the Bcar3 gene associated with lens extrusion cataracts., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TNC9;Q3UP10", "ec_number_list": [], "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0019900 kinase binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005925 focal adhesion;GO:0016020 membrane", "go_biological_process": "GO:0086100 endothelin receptor signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0033138 positive regulation of peptidyl-serine phosphorylation;GO:0043410 positive regulation of MAPK cascade;GO:0043547 positive regulation of GTPase activity", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q9QZK2-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60809-1", "uniprot_id": [ { "id": "CNOT7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60809", "type": "external" } ], "mass": 32718.0, "length": 285, "protein_name": "CCR4-NOT transcription complex subunit 7", "gene_name": "Cnot7", "organism": "Mouse", "refseq_name": "CCR4-NOT transcription complex subunit 7 isoform 1", "refseq_ac": [ { "id": "NP_001258471", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258471", "type": "external" } ], "gene_names_uniprotkb": "Cnot7; Caf1", "gene_names_refseq": "CAF-1; Caf1; Cnot7; Pop2", "protein_names_uniprotkb": "CCR4-NOT transcription complex subunit 7; 3.1.13.4; CAF-1; CCR4-associated factor 1", "protein_names_refseq": "CCR4-NOT transcription complex subunit 7 isoform 1; CCR4-associated factor 1; POP2 homolog; catabolite repressor protein (CCR4)-associative factor 1", "tax_id": 10090, "disease": "heart disease (Disease Ontology:DOID:114); male infertility (Disease Ontology:DOID:12336)", "pathway": " (mmu:18983); (R-MMU-429947); (R-MMU-6804115)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "19716330;20133598;22367759;27065194;7791755;9712883", "class_list": "", "function": "Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex also seems to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for miRNA-mediated mRNA deadenylation. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.1.13.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.4", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0003714 transcription corepressor activity;GO:0000175 3'-5'-RNA exonuclease activity;GO:0004532 RNA exonuclease activity;GO:0004535 poly(A)-specific ribonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0016604 nuclear body", "go_biological_process": "GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:0006351 DNA-templated transcription;GO:0006417 regulation of translation;GO:0007283 spermatogenesis;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q60809-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D4J3-1", "uniprot_id": [ { "id": "DCBD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D4J3", "type": "external" } ], "mass": 54518.0, "length": 503, "protein_name": "Discoidin, CUB and LCCL domain-containing protein 1", "gene_name": "Dcbld1", "organism": "Mouse", "refseq_name": "discoidin, CUB and LCCL domain-containing protein 1 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001334373", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334373", "type": "external" } ], "gene_names_uniprotkb": "Dcbld1", "gene_names_refseq": "4631413K11Rik; Dcbld1", "protein_names_uniprotkb": "Discoidin, CUB and LCCL domain-containing protein 1", "protein_names_refseq": "discoidin, CUB and LCCL domain-containing protein 1 isoform 2 precursor; discoidin, CUB and LCCL domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66686)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21183079;26495903", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8R327;Q9D696", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D4J3-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62371-1", "uniprot_id": [ { "id": "DDR2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62371", "type": "external" } ], "mass": 96482.0, "length": 854, "protein_name": "Discoidin domain-containing receptor 2", "gene_name": "Ddr2", "organism": "Mouse", "refseq_name": "discoidin domain-containing receptor 2 precursor", "refseq_ac": [ { "id": "NP_072075", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_072075", "type": "external" } ], "gene_names_uniprotkb": "Ddr2; Ntrkr3; Tkt; Tyro10", "gene_names_refseq": "Ddr2; Ntrkr3; tyro10", "protein_names_uniprotkb": "Discoidin domain-containing receptor 2; 2.7.10.1; CD167 antigen-like family member B; Discoidin domain receptor 2; Neurotrophic tyrosine kinase, receptor-related 3; Receptor protein-tyrosine kinase TKT; Tyrosine-protein kinase TYRO10", "protein_names_refseq": "CD167 antigen-like family member B; discoidin domain receptor 2; discoidin domain-containing receptor 2 precursor; discoidin domain-containing receptor 2; neurotrophic tyrosine kinase, receptor-related 3; receptor protein-tyrosine kinase TKT; tyrosine-protein kinase TYRO10", "tax_id": 10090, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); spondylometaepiphyseal dysplasia, short limb-hand type (Disease Ontology:DOID:0112196); stomach cancer (Disease Ontology:DOID:10534); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); gallbladder adenocarcinoma (Disease Ontology:DOID:3500); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); adenosquamous gallbladder carcinoma (Disease Ontology:DOID:5627); hepatocellular carcinoma (Disease Ontology:DOID:684); osteoarthritis (Disease Ontology:DOID:8398); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (mmu:18214); (R-MMU-3000171)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "11375938;11723120;11884411;15509586;18483174;19681157;21750661;25428506;30084848;30779550;31219806;34428180;36210013;36745969;37583038;37828378;37996700;38332727;8108131;8247548", "class_list": "", "function": "Ablation of myeloid discoidin domain receptor 2 exacerbates arthritis and high fat diet induced inflammation., [RefSeq, PubMed]; DDR2-regulated arginase activity in ovarian cancer-associated fibroblasts promotes collagen production and tumor progression., [RefSeq, PubMed]; Discoidin domain receptor 2 signaling through PIK3C2alpha in fibroblasts promotes lung fibrosis., [RefSeq, PubMed]; Tyrosine kinase that functions as a cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; [Application of precision-cut lung slice technology to study the role of DDR2 in pulmonary fibrosis]., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "B2RSD7", "ec_number_list": [ { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0005518 collagen binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity;GO:0038062 protein tyrosine kinase collagen receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton;GO:0043235 receptor complex;GO:0016324 apical plasma membrane", "go_biological_process": "GO:1904385 cellular response to angiotensin;GO:2000491 positive regulation of hepatic stellate cell activation;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0010976 positive regulation of neuron projection development", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q62371-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2RSQ0-1", "uniprot_id": [ { "id": "DEN5B_MOUSE", "url": "https://www.uniprot.org/uniprot/A2RSQ0", "type": "external" } ], "mass": 144629.0, "length": 1274, "protein_name": "DENN domain-containing protein 5B", "gene_name": "Dennd5b", "organism": "Mouse", "refseq_name": "DENN domain-containing protein 5B", "refseq_ac": [ { "id": "NP_796166", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796166", "type": "external" } ], "gene_names_uniprotkb": "Dennd5b", "gene_names_refseq": "9330160C06Rik; D030011O10Rik; Dennd5b; Gm17524", "protein_names_uniprotkb": "DENN domain-containing protein 5B; Rab6IP1-like protein", "protein_names_refseq": "DENN domain-containing protein 5B; DENN/MADD domain containing 5B; RAB6IP1-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:320560); (R-MMU-8876198)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "17242355;21183079;21750661;30084848;30837651;34428180;35820727;36243100", "class_list": "", "function": "DENND5B Regulates Intestinal Triglyceride Absorption and Body Mass. Publication Status: Online-Only, [RefSeq, PubMed]; Dennd5b-Deficient Mice are Resistant to PCSK9-Induced Hypercholesterolemia and Diet-Induced Hepatic Steatosis., [RefSeq, PubMed]; Guanine nucleotide exchange factor (GEF) which may activate RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BII7;Q8BWK2", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:1905885 positive regulation of triglyceride transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A2RSQ0-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q557-1", "uniprot_id": [ { "id": "DESP_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q557", "type": "external" } ], "mass": 332912.0, "length": 2883, "protein_name": "Desmoplakin", "gene_name": "Dsp", "organism": "Mouse", "refseq_name": "desmoplakin isoform 1", "refseq_ac": [ { "id": "NP_076331", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076331", "type": "external" } ], "gene_names_uniprotkb": "Dsp", "gene_names_refseq": "2300002E22Rik; 5730453H04Rik; DP; Dsp; rul", "protein_names_uniprotkb": "Desmoplakin; DP", "protein_names_refseq": "desmoplakin I/II; desmoplakin isoform 1; desmosomal cytoskeletal connector molecule", "tax_id": 10090, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); keratosis palmoplantaris striata 2 (Disease Ontology:DOID:0081109); Carvajal syndrome (Disease Ontology:DOID:0090128); arrhythmogenic right ventricular dysplasia 8 (Disease Ontology:DOID:0110076); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (mmu:109620); (R-MMU-351906); (R-MMU-6798695); (R-MMU-6805567); (R-MMU-6809371); (R-MMU-9696264); (R-MMU-9696273)", "pathway_count": 7, "publication_count": 37, "publication_id_list": "11222147;12494996;15479741;16917092;17227889;17242355;18079750;21183079;21285247;21750661;22515648;24129315;25428506;25496840;25733715;26403541;27033150;27097650;27375112;28011936;28507225;29959233;30084848;30389720;31219806;32069316;32152506;34428180;34887587;35119382;35820727;36064721;36210013;37507081;38395410;39627609;9864371", "class_list": "", "function": "A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (By similarity). Critical for cell-cell adhesion in early stage blastocysts and progression through proamniotic cavity formation (PubMed:9864371). Not required for preimplantation morphogenic process in blastocysts (PubMed:9864371). Required for keratin filament anchoring at the desmosome junction and subsequent organization of the keratin intermediate filament network within the cytoplasm (PubMed:9864371). Required for anchoring of desmosomes to the microtubule architecture, via its interaction with NIN (PubMed:17227889). Promotes microtubule-mediated GJA1/CX43 trafficking to cell membranes via its interaction with MAPRE1/EB1, thereby facilitating gap junction intracellular communication (By similarity). Plays a key role in adhesion and organization of the dermal epithelial barrier (PubMed:11222147). Critical for the maintenance of the neural tube structure following formation and organization of the neuroepithelium (PubMed:11222147). Facilitates outgrowth and repair of motor neuron fibers in regenerating axons following injury, probably by promoting recruitment of a complex containing DSP, CDH2, VIM and JUP to the outgrowth tips (PubMed:25496840). Critical for the normal formation of heart and myocardial tissue during early embryogenesis (PubMed:11222147, PubMed:16917092). Also required for development of vascular capillary structures and intact endothelial cell barriers (PubMed:11222147). Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). Maintains cardiac rhythmicity by ensuring correct cell-cell adhesion within the sinoatrial node, via stabilization of protein components of both desmosome and Gap junctions (PubMed:27097650). Involved in maintaining the protein stability and recruitment of GJA1 to functional gap junctions, via inhibition of KRAS-mediated MAPK1/MAPK3 phosphorylation of GJA1 (PubMed:29959233). Negative regulator of cell cycle progression and differentiation in keratinocytes, potentially via inhibition of MAPK and phosphoinositide-3-kinase (PI3K) signaling pathways (By similarity). Mediates the interaction between the desmosome and COP9 signalosome complex (CSN) protein complex (By similarity). As a result of this interaction, promotes keratinocyte differentiation via deneddylation of EGFR resulting in a reduction in EGFR protein stabilization and translocation away from the cell membrane (By similarity). Required for the maintenance of protein abundance of desmosome junction components DSG1, DSG2, DSC2, DSC3, PKP1, PKP2 and PKP3 (By similarity). Required for the survival and maintenance of germ cells in the gonads during embryonic development (PubMed:35119382). Binds to telomere DNA (via C-terminus) and acts to prevent telomere damage and maintain telomere length via its interaction with TRF2 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 29, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0005080 protein kinase C binding;GO:0005198 structural molecule activity;GO:0097110 scaffold protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0150105 protein localization to cell-cell junction;GO:0086091 regulation of heart rate by cardiac conduction;GO:0030216 keratinocyte differentiation;GO:0098609 cell-cell adhesion;GO:0018149 peptide cross-linking", "synthesized_glycan_count": 0, "hit_score": 4.0, "record_id": "E9Q557-1", "record_type": "protein", "filter_code": "0000000.0100111.001000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62167-1", "uniprot_id": [ { "id": "DDX3X_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62167", "type": "external" } ], "mass": 73101.0, "length": 662, "protein_name": "ATP-dependent RNA helicase DDX3X", "gene_name": "Ddx3x", "organism": "Mouse", "refseq_name": "ATP-dependent RNA helicase DDX3X", "refseq_ac": [ { "id": "NP_034158", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034158", "type": "external" } ], "gene_names_uniprotkb": "Ddx3x; D1Pas1-rs2; Ddx3; Dead3; Erh", "gene_names_refseq": "D1Pas1-rs2; Ddx3x; Ddx3; Fin14", "protein_names_uniprotkb": "ATP-dependent RNA helicase DDX3X; 3.6.4.13; D1Pas1-related sequence 2; DEAD box RNA helicase DEAD3; DEAD box protein 3, X-chromosomal; Embryonic RNA helicase; mDEAD3", "protein_names_refseq": "ATP-dependent RNA helicase DDX3X; D-E-A-D (aspartate-glutamate-alanine-aspartate) box polypeptide 3; D1Pas1-related sequence 2; DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 3; DEAD box RNA helicase DEAD3; DEAD box protein 3, X-chromosomal; DEAD-box protein 3 (DEAD-box RNA helicase DEAD3) (mDEAD3) (Embryonic RNA helicase) (D1PAS1 related sequence 2); DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked; embryonic RNA helicase; fibroblast growth factor inducible 14; mDEAD3", "tax_id": 10090, "disease": "Sertoli cell-only syndrome (Disease Ontology:DOID:0050457); syndromic X-linked intellectual disability (Disease Ontology:DOID:0060309); childhood medulloblastoma (Disease Ontology:DOID:3869); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:13205); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 22, "publication_id_list": "10859333;15592455;17242355;18583960;23806337;24129315;25050112;25153642;25605945;27179789;28528544;30475900;30613052;31511697;33300544;34428180;34887587;37453647;39627609;39927985;8144024;8948440", "class_list": "", "function": "Multifunctional ATP-dependent RNA helicase. The ATPase activity can be stimulated by various ribo-and deoxynucleic acids indicative for a relaxed substrate specificity. In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs. Binds RNA G-quadruplex (rG4s) structures, including those located in the 5'-UTR of NRAS mRNA. Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities. Involved in transcription regulation. Positively regulates CDKN1A/WAF1/CIP1 transcription in an SP1-dependent manner, hence inhibits cell growth. This function requires its ATPase, but not helicase activity. CDKN1A up-regulation may be cell-type specific. Binds CDH1/E-cadherin promoter and represses its transcription. Potentiates HNF4A-mediated MTTP transcriptional activation; this function requires ATPase, but not helicase activity. Facilitates HNF4A acetylation, possibly catalyzed by CREBBP/EP300, thereby increasing the DNA-binding affinity of HNF4 to its response element. In addition, disrupts the interaction between HNF4 and SHP that forms inactive heterodimers and enhances the formation of active HNF4 homodimers. By promoting HNF4A-induced MTTP expression, may play a role in lipid homeostasis. May positively regulate TP53 transcription. Associates with mRNPs, predominantly with spliced mRNAs carrying an exon junction complex (EJC). Involved in the regulation of translation initiation. Not involved in the general process of translation, but promotes efficient translation of selected complex mRNAs, containing highly structured 5'-untranslated regions (UTR). This function depends on helicase activity. Might facilitate translation by resolving secondary structures of 5'-UTRs during ribosome scanning. Alternatively, may act prior to 43S ribosomal scanning and promote 43S pre-initiation complex entry to mRNAs exhibiting specific RNA motifs, by performing local remodeling of transcript structures located close to the cap moiety. Independently of its ATPase activity, promotes the assembly of functional 80S ribosomes and disassembles from ribosomes prior to the translation elongation process. Positively regulates the translation of cyclin E1/CCNE1 mRNA and consequently promotes G1/S-phase transition during the cell cycle. May activate TP53 translation. Required for endoplasmic reticulum stress-induced ATF4 mRNA translation. Independently of its ATPase/helicase activity, enhances IRES-mediated translation; this activity requires interaction with EIF4E. Independently of its ATPase/helicase activity, has also been shown specifically repress cap-dependent translation, possibly by acting on translation initiation factor EIF4E. Involved in innate immunity, acting as a viral RNA sensor. Binds viral RNAs and promotes the production of type I interferon (IFN-alpha and IFN-beta). Potentiate MAVS/RIGI-mediated induction of IFNB in early stages of infection (By similarity). Enhances IFNB1 expression via IRF3/IRF7 pathway and participates in NFKB activation in the presence of MAVS and TBK1 (PubMed:30475900). Involved in TBK1 and IKBKE-dependent IRF3 activation leading to IFNB induction, acts as a scaffolding adapter that links IKBKE and IRF3 and coordinates their activation. Involved in the TLR7/TLR8 signaling pathway leading to type I interferon induction, including IFNA4 production. In this context, acts as an upstream regulator of IRF7 activation by MAP3K14/NIK and CHUK/IKKA. Stimulates CHUK autophosphorylation and activation following physiological activation of the TLR7 and TLR8 pathways, leading to MAP3K14/CHUK-mediated activatory phosphorylation of IRF7. Also stimulates MAP3K14/CHUK-dependent NF-kappa-B signaling. Negatively regulates TNF-induced IL6 and IL8 expression, via the NF-kappa-B pathway. May act by interacting with RELA/p65 and trapping it in the cytoplasm. May also bind IFNB promoter; the function is independent of IRF3 (By similarity). Involved in both stress and inflammatory responses (PubMed:31511697). Independently of its ATPase/helicase activity, required for efficient stress granule assembly through its interaction with EIF4E, hence promotes survival in stressed cells (By similarity). Independently of its helicase activity, regulates NLRP3 inflammasome assembly through interaction with NLRP3 and hence promotes cell death by pyroptosis during inflammation. This function is independent of helicase activity. Therefore DDX3X availability may be used to interpret stress signals and choose between pro-survival stress granules and pyroptotic NLRP3 inflammasomes and serve as a live-or-die checkpoint in stressed cells (PubMed:31511697). In association with GSK3A/B, negatively regulates extrinsic apoptotic signaling pathway via death domain receptors, including TNFRSF10B, slowing down the rate of CASP3 activation following death receptor stimulation. Cleavage by caspases may inactivate DDX3X and relieve the inhibition. Independently of its ATPase/helicase activity, allosteric activator of CSNK1E. Stimulates CSNK1E-mediated phosphorylation of DVL2, thereby involved in the positive regulation of Wnt/beta-catenin signaling pathway. Also activates CSNK1A1 and CSNK1D in vitro, but it is uncertain if these targets are physiologically relevant. ATPase and casein kinase-activating functions are mutually exclusive. May be involved in mitotic chromosome segregation (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O09060;O09143", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": 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"url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "5.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0003924 GTPase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005813 centrosome", "go_biological_process": "GO:0032727 positive regulation of interferon-alpha production;GO:1903608 protein localization to cytoplasmic stress granule;GO:0006351 DNA-templated transcription;GO:0006954 inflammatory response;GO:0007059 chromosome segregation", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q62167-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62418-1", "uniprot_id": [ { "id": "DBNL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62418", "type": "external" } ], "mass": 48700.0, "length": 436, "protein_name": "Drebrin-like protein", "gene_name": "Dbnl", "organism": "Mouse", "refseq_name": "drebrin-like protein isoform 1", "refseq_ac": [ { "id": "NP_001139780", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139780", "type": "external" } ], "gene_names_uniprotkb": "Dbnl; Abp1; Sh3p7", "gene_names_refseq": "Abp1; Dbnl; SH3P7; mAbp1", "protein_names_uniprotkb": "Drebrin-like protein; Actin-binding protein 1; SH3 domain-containing protein 7", "protein_names_refseq": "SH3 domain-containing protein 7; actin-binding protein 1; drebrin-like protein isoform 1; drebrin-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:13169)", "pathway_count": 1, "publication_count": 29, "publication_id_list": "10.1101/2023.09.13.557529;10637315;11309416;12913069;16452483;17242355;17476322;18829961;19064729;21183079;22303001;22645316;22872234;23223303;25153642;25428506;26495903;28135057;28528544;30016717;30504273;32848054;34428180;35822049;36288343;40021952;40885482;9630982;9891087", "class_list": "", "function": "Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes. May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; The novel protein Dbnl, an actin-binding protein, controls multiple events during neuronal migration in the developing mouse cerebral cortex, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q3TG34;Q3U5X3;Q3U8I5;Q3UZ33;Q5NCI5;Q5NCI6;Q5NCI7;Q80WP1;Q8BH56", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0019904 protein domain specific binding;GO:0051015 actin filament binding;GO:0098973 structural constituent of postsynaptic actin cytoskeleton", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005829 cytosol", "go_biological_process": "GO:0006897 endocytosis;GO:0048812 neuron projection morphogenesis;GO:0007416 synapse assembly;GO:0016601 Rac protein signal transduction;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 3.9, "record_id": "Q62418-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R2F2-1", "uniprot_id": [ { "id": "DEGS2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R2F2", "type": "external" } ], "mass": 37491.0, "length": 323, "protein_name": "Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2", "gene_name": "Degs2", "organism": "Mouse", "refseq_name": "sphingolipid delta(4)-desaturase/C4-monooxygenase DES2 isoform 2", "refseq_ac": [ { "id": "NP_001164473", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164473", "type": "external" } ], "gene_names_uniprotkb": "Degs2", "gene_names_refseq": "2210008A03Rik; DES2; Degs2", "protein_names_uniprotkb": "Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2; 1.14.18.5; 1.14.19.17; Degenerative spermatocyte homolog 2; Sphingolipid 4-desaturase; Sphingolipid C4-monooxygenase", "protein_names_refseq": "degenerative spermatocyte homolog 2, lipid desaturase; sphingolipid 4-desaturase; sphingolipid C4-monooxygenase; sphingolipid delta 4 desaturase/C-4 hydroxylase; sphingolipid delta(4)-desaturase/C4-hydroxylase DES2; sphingolipid delta(4)-desaturase/C4-monooxygenase DES2 isoform 2; sphingolipid delta(4)-desaturase/C4-monooxygenase DES2", "tax_id": 10090, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:70059); (R-MMU-1660661)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "11937514;14731113;15474011;16571104;21750661;30084848;34428180;36907437", "class_list": "glycogene", "function": "Bifunctional DEGS2 has higher hydroxylase activity toward substrates with very-long-chain fatty acids in the production of phytosphingosine ceramides., [RefSeq, PubMed]; Bifunctional enzyme which acts both as a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase., [UniProtKB, PubMed, PubMed, PubMed]; DES2 is the dihydroceramide C-4 hydroxylase responsible for the biosynthesis of enriched phytosphingoglycolipids in the microvillous membranes of intestinal epithelial cells, [RefSeq, PubMed]; The hydroxylation of dihydroceramide: sphinganine C-4 requires complex formation between Des2 and mb5 via their membrane-spanning domains and electron transfer from NADH to the substrate via the reduction of mb5 by b5R, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 11, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TR85;Q78JJ1", "ec_number_list": [ { "id": "1.14.19.17", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.17", "type": "external" }, { "id": "5.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.-", "type": "external" }, { "id": "1.14.18.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.18.5", "type": "external" } ], "go_molecular_function": "GO:0042284 sphingolipid delta-4 desaturase activity;GO:0102772 sphingolipid C4-monooxygenase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0046513 ceramide biosynthetic process;GO:0030148 sphingolipid biosynthetic process;GO:0006667 sphinganine metabolic process;GO:0008610 lipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8R2F2-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000000000.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2A7-1", "uniprot_id": [ { "id": "DGAT1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z2A7", "type": "external" } ], "mass": 56790.0, "length": 498, "protein_name": "Diacylglycerol O-acyltransferase 1", "gene_name": "Dgat1", "organism": "Mouse", "refseq_name": "diacylglycerol O-acyltransferase 1", "refseq_ac": [ { "id": "NP_034176", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034176", "type": "external" } ], "gene_names_uniprotkb": "Dgat1; Dgat", "gene_names_refseq": "ARAT; D15Ertd23e; Dgat1; Dgat", "protein_names_uniprotkb": "Diacylglycerol O-acyltransferase 1; 2.3.1.20; 2.3.1.76; ARAT; Acyl-CoA retinol O-fatty-acyltransferase; Diglyceride acyltransferase; Retinol O-fatty-acyltransferase", "protein_names_refseq": "acyl-CoA retinol O-fatty-acyltransferase; diacylglycerol O-acyltransferase 1; diglyceride acyltransferase", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); congenital diarrhea 7 with exudative enteropathy (Disease Ontology:DOID:0060778); nephrotic syndrome (Disease Ontology:DOID:1184); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (mmu:13350); (R-MMU-1482883); (R-MMU-6798695); (R-MMU-75109)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "10802663;11956242;11959864;15834126;16106050;19028692;20876538;22493088;23066022;26942218;28420705;34428180;9789033", "class_list": "", "function": "Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates (PubMed:15834126, PubMed:19028692, PubMed:20876538, PubMed:22493088, PubMed:28420705). Highly expressed in epithelial cells of the small intestine and its activity is essential for the absorption of dietary fats (By similarity). In liver, plays a role in esterifying exogenous fatty acids to glycerol, and is required to synthesize fat for storage (PubMed:15834126). Also present in female mammary glands, where it produces fat in the milk (By similarity). May be involved in VLDL (very low density lipoprotein) assembly (By similarity). In contrast to DGAT2 it is not essential for survival (PubMed:11959864). Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders (PubMed:19028692). Exhibits additional acyltransferase activities, includin acyl CoA:monoacylglycerol acyltransferase (MGAT), wax monoester and wax diester synthases (PubMed:15834126). Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (PubMed:28420705)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D7Q5", "ec_number_list": [ { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.75", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.75", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "1.14.19.17", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.17", "type": "external" }, { "id": "5.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.-", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "3.4.21.73", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.73", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "2.3.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.78", "type": "external" }, { "id": "1.6.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.-", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "2.3.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.20", "type": "external" }, { "id": "2.3.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.76", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "2.3.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.22", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" } ], "go_molecular_function": "GO:0005504 fatty acid binding;GO:0042802 identical protein binding;GO:0004144 diacylglycerol O-acyltransferase activity;GO:0019992 diacylglycerol binding;GO:0016746 acyltransferase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0046339 diacylglycerol metabolic process;GO:2000491 positive regulation of hepatic stellate cell activation;GO:1903998 regulation of eating behavior;GO:1904729 regulation of intestinal lipid absorption;GO:0001523 retinoid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9Z2A7-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08808-1", "uniprot_id": [ { "id": "DIAP1_MOUSE", "url": "https://www.uniprot.org/uniprot/O08808", "type": "external" } ], "mass": 139343.0, "length": 1255, "protein_name": "Protein diaphanous homolog 1", "gene_name": "Diaph1", "organism": "Mouse", "refseq_name": "protein diaphanous homolog 1 isoform 2", "refseq_ac": [ { "id": "NP_031884", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031884", "type": "external" } ], "gene_names_uniprotkb": "Diaph1; Diap1", "gene_names_refseq": "D18Wsu154e; Dia1; Diap1; Diaph1; Drf1; p140mDia", "protein_names_uniprotkb": "Protein diaphanous homolog 1; DRF1; Diaphanous-related formin-1; mDIA1; p140mDIA", "protein_names_refseq": "protein diaphanous homolog 1 isoform 2; protein diaphanous homolog 1", "tax_id": 10090, "disease": "autosomal dominant auditory neuropathy 1 (Disease Ontology:DOID:0060690); autosomal dominant nonsyndromic deafness 1 (Disease Ontology:DOID:0110541); sensorineural hearing loss (Disease Ontology:DOID:10003); microcephaly (Disease Ontology:DOID:10907)", "pathway": " (mmu:13367); (R-MMU-5663220); (R-MMU-6785631); (R-MMU-6798695); (R-MMU-8980692); (R-MMU-9013026); (R-MMU-9013106); (R-MMU-9035034)", "pathway_count": 8, "publication_count": 23, "publication_id_list": "10.1101/2023.09.13.557529;10678165;10814512;14992721;15044801;15311282;15864301;16292343;16452087;17947660;18572016;19350017;21750661;23558171;24781755;25428506;27808407;30084848;31219806;34428180;38843827;39627609;9214622", "class_list": "", "function": "Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers (PubMed:10678165, PubMed:15044801, PubMed:18572016, PubMed:23558171). Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization (PubMed:10678165, PubMed:15044801, PubMed:18572016). Required for cytokinesis, and transcriptional activation of the serum response factor (PubMed:10678165, PubMed:15044801, PubMed:18572016). DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics (PubMed:10678165, PubMed:15044801, PubMed:18572016). Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration (PubMed:15311282). Has neurite outgrowth promoting activity (PubMed:10678165, PubMed:15044801, PubMed:18572016). Acts in a Rho-dependent manner to recruit PFY1 to the membrane (PubMed:9214622). The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (By similarity). It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity (By similarity). In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). Required in the control of cell shape (By similarity). Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity (PubMed:23558171)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Mechanisms of actin filament severing and elongation by formins., [RefSeq, PubMed]; This gene encodes a member of the formin family of proteins that play important roles in cytoskeletal rearragnement by nucleation of actin filaments. Mice lacking the encoded protein develop age-dependent myeloproliferative defects resembling human myeloproliferative syndrome and myelodysplastic syndromes. Trafficking of T lymphocytes to secondary lymphoid organs and egression of thymocytes from the thymus are impaired in these animals. Lack of the encoded protein in T lymphocytes and thymocytes also reduces chemotaxis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0042802 identical protein binding;GO:0044325 transmembrane transporter binding;GO:0031267 small GTPase binding;GO:0005522 profilin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005884 actin filament;GO:0005903 brush border", "go_biological_process": "GO:0016199 axon midline choice point recognition;GO:0030335 positive regulation of cell migration;GO:0031175 neuron projection development;GO:0048013 ephrin receptor signaling pathway;GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "O08808-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62356-1", "uniprot_id": [ { "id": "FSTL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62356", "type": "external" } ], "mass": 34554.0, "length": 306, "protein_name": "Follistatin-related protein 1", "gene_name": "Fstl1", "organism": "Mouse", "refseq_name": "follistatin-related protein 1 precursor", "refseq_ac": [ { "id": "NP_032073", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032073", "type": "external" } ], "gene_names_uniprotkb": "Fstl1; Frp; Fstl; Tsc36", "gene_names_refseq": "Fstl1; Fstl; TSC-36", "protein_names_uniprotkb": "Follistatin-related protein 1; Follistatin-like protein 1; TGF-beta-inducible protein TSC-36", "protein_names_refseq": "TGF-beta-inducible protein TSC-36; follistatin-like protein 1; follistatin-related protein 1 precursor; follistatin-related protein 1", "tax_id": 10090, "disease": "pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (mmu:14314); (R-MMU-201451); (R-MMU-381426); (R-MMU-8957275)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;16944957;19595790;20054002;21826198;31351024;35820727;38436106;7901004", "class_list": "", "function": "Follistatin-like 1 protects against doxorubicin-induced cardiotoxicity by preventing mitochondrial dysfunction through the SIRT6/Nrf2 signaling pathway., [RefSeq, PubMed]; Secreted glycoprotein that is involved in various physiological processes, such as angiogenesis, regulation of the immune response, cell proliferation and differentiation (By similarity). Plays a role in the development of the central nervous system, skeletal system, lungs, and ureter (PubMed:19595790, PubMed:21826198). Promotes endothelial cell survival, migration and differentiation into network structures in an AKT-dependent manner. Also promotes survival of cardiac myocytes (PubMed:20054002). Initiates various signaling cascades by activating different receptors on the cell surface such as DIP2A, TLR4 or BMP receptors (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9452, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q6GTX2;Q99JI9", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0030154 cell differentiation;GO:0043066 negative regulation of apoptotic process;GO:0043542 endothelial cell migration;GO:0030510 regulation of BMP signaling pathway;GO:0061484 hematopoietic stem cell homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q62356-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88904-1", "uniprot_id": [ { "id": "HIPK1_MOUSE", "url": "https://www.uniprot.org/uniprot/O88904", "type": "external" } ], "mass": 130723.0, "length": 1210, "protein_name": "Homeodomain-interacting protein kinase 1", "gene_name": "Hipk1", "organism": "Mouse", "refseq_name": "homeodomain-interacting protein kinase 1 isoform 1", "refseq_ac": [ { "id": "NP_001288233", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001288233", "type": "external" } ], "gene_names_uniprotkb": "Hipk1; Kiaa0630; Myak; Nbak2", "gene_names_refseq": "1110062K04Rik; Hipk1; Myak", "protein_names_uniprotkb": "Homeodomain-interacting protein kinase 1; 2.7.11.1; Nuclear body-associated kinase 2; Protein kinase Myak", "protein_names_refseq": "homeodomain-interacting protein kinase 1 isoform 1; nuclear body-associated kinase 2; protein kinase Myak", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330); depressive disorder (Disease Ontology:DOID:1596); cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:15257); (R-MMU-6804756)", "pathway_count": 2, "publication_count": 32, "publication_id_list": "10.1101/2023.09.13.557529;10694743;12529400;12702766;16917507;17114649;18219322;18299400;19224205;20173027;20231426;20579985;21750661;21952136;22095214;22545114;22645316;25428506;30084848;30613263;30779550;31219806;32782141;32848054;34428180;34887587;35820727;36084651;36210013;36852467;40885482;9748262", "class_list": "", "function": "Despite the expanded marginal zone B cell population in the HIPK1(-/-) mice, the T-independent type 2 humoral response was impaired., [RefSeq, PubMed]; HIPK1 and Daxx collaborate in regulating transcription., [RefSeq, PubMed]; Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation. Phosphorylates PAGE4 at 'Thr-51' which is critical for the ability of PAGE4 to potentiate the transcriptional activator activity of JUN (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]; The miR-200c/141 cluster regulated breast cancer stem cells heterogeneity and promoted the epithelial-mesenchymal transformation-like breast cancer stem cells generation, which resulted in increased tumor metastasis and inhibited tumor growth by directly upregulating the target gene homeodomain-interacting protein kinase 1 (HIPK1) and sequential beta-catenin activation. Publication Status: Online-Only, [RefSeq, PubMed]; Therefore, our data confirm that the beta-Catenin signaling plays a dual role in controlling cell proliferation/differentiation in the brain and indicate that Hipk1 is the crucial interactor able to revert the outcome of beta-Catenin signaling in cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A6H5Z7;Q80TV5;Q9QUQ8;Q9QZR3;Q9WVN7", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0060059 embryonic retina morphogenesis in camera-type eye;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006468 protein phosphorylation;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 4.0, "record_id": "O88904-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11881-1", "uniprot_id": [ { "id": "ITPR1_MOUSE", "url": "https://www.uniprot.org/uniprot/P11881", "type": "external" } ], "mass": 313167.0, "length": 2749, "protein_name": "Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1", "gene_name": "Itpr1", "organism": "Mouse", "refseq_name": "inositol 1,4,5-trisphosphate-gated calcium channel ITPR1", "refseq_ac": [ { "id": "NP_034715", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034715", "type": "external" } ], "gene_names_uniprotkb": "Itpr1; Insp3r; Pcd6; Pcp1", "gene_names_refseq": "D6Pas2; Gm10429; IP3R 1; IP3R1; InsP3R; Ip3r; Itpr-1; Itpr1; P400; Pcp-1; Pcp1; insP3R1; opt; wblo", "protein_names_uniprotkb": "Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1; IP3 receptor isoform 1; IP3R 1; Inositol 1,4,5 trisphosphate receptor; Inositol 1,4,5-trisphosphate receptor type 1; Inositol 1,4,5-trisphosphate-binding protein P400; InsP3R1; Protein PCD-6; Purkinje cell protein 1; Type 1 InsP3 receptor; Type 1 inositol 1,4,5-trisphosphate receptor", "protein_names_refseq": "IP3 receptor; InsP>34) linkage to the non-reducing terminal N-acetylglucosamine (GlcNAc) moieties of glycolipids and complex-type N-linked glycans (By similarity). Adds one Gal residue to both GlcNAc beta(1->2)-linked to the alpha(1->3) and alpha(1->6) mannose antennae of complex-type N-glycans, enabling the formation of mono- and di-galactosylated glycoforms (By similarity). Galactosylates complex-type N-glycans attached on the fragment crystallizable (Fc) of immunoglobulin-gamma isotypes (IgGs), a prerequisite for antibody glycan sialylation and related anti-inflammatory effector functions (By similarity). Can also transfer a Gal residue to free GlcNAc to form N-acetyllactosamine (By similarity). With LALBA/alpha-lactalbumin forms the lactose synthase complex responsible for production of large amounts of lactose in the lactating mammary gland. Interaction with LALBA alters the sugar substrate specificity of the catalytic domain, enabling high affinity binding of glucose and its transformation to lactose (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; MicroRNA-15a/beta1,4-GalT-I axis contributes to cartilage degeneration via NF-kappaB signaling in osteoarthritis. Publication Status: Online-Only, [RefSeq, PubMed]; The cell surface form functions as a recognition molecule during a variety of cell to cell and cell to matrix interactions, like those occurring during development and egg fertilization, by binding to specific oligosaccharide ligands on opposing cells or in the extracellular matrix. Acts as a sperm receptor for ZP3 O-linked glycans on the zona pellucida leading to activation of G protein signaling and acrosome reaction., [UniProtKB, PubMed]; The secreted form is proficient in galactosyltransferase activity and could be involved in glycan remodeling in biological fluids., [UniProtKB, UniProtKB]; This gene encodes two distinct enzyme isoforms, a long membrane-bound form and a short soluble form. These alternate isoforms are thought to be produced through alternative nested transcription initiation and different in-frame start codon usage. These enzymes catalyze the transfer of galactose to acceptor sugars, such as N-acetylglucosamine and glucose. The long form of this enzyme is localized to the trans-Golgi membrane and is involved in glycoconjugate biosynthesis. The short form functions in lactose biosynthesis though formation of a heterodimer with alpha-lactalbumin. [provided by RefSeq, Nov 2012]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 20, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.275", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.275", "type": "external" }, { "id": "2.4.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.22", "type": "external" }, { "id": "2.4.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.38", "type": "external" }, { "id": "2.4.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.90", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.4.23.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.-", "type": "external" }, { "id": "3.2.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.20", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.4.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.2", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67", "type": "external" }, { "id": "2.3.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "3.4.24.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.11", "type": "external" }, { "id": "3.4.16.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.2", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.2.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.25", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "2.4.1.274", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.274", "type": "external" }, { "id": "3.5.1.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.92", "type": "external" } ], "go_molecular_function": "GO:0008378 galactosyltransferase activity;GO:0030145 manganese ion binding;GO:0042802 identical protein binding;GO:0043236 laminin binding;GO:0008092 cytoskeletal protein binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0007155 cell adhesion;GO:0007339 binding of sperm to zona pellucida;GO:0008285 negative regulation of cell population proliferation;GO:0030198 extracellular matrix organization", "synthesized_glycan_count": 10444, "hit_score": 2.2, "record_id": "P15535-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0100000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21274-1", "uniprot_id": [ { "id": "BMP2_MOUSE", "url": "https://www.uniprot.org/uniprot/P21274", "type": "external" } ], "mass": 44525.0, "length": 394, "protein_name": "Bone morphogenetic protein 2", "gene_name": "Bmp2", "organism": "Mouse", "refseq_name": "bone morphogenetic protein 2 preproprotein", "refseq_ac": [ { "id": "NP_031579", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031579", "type": "external" } ], "gene_names_uniprotkb": "Bmp2; Bmp-2", "gene_names_refseq": "Bmp2a; Bmp2", "protein_names_uniprotkb": "Bone morphogenetic protein 2; BMP-2A; BMP-2; Bone morphogenetic protein 2A", "protein_names_refseq": "bone morphogenetic protein 2 preproprotein; bone morphogenetic protein 2A", "tax_id": 10090, "disease": "tooth agenesis (Disease Ontology:DOID:0050591); juvenile polyposis syndrome (Disease Ontology:DOID:0050787); short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 1 (Disease Ontology:DOID:0060989); brachydactyly type A2 (Disease Ontology:DOID:0110965); hemochromatosis type 1 (Disease Ontology:DOID:0111029); prostate cancer (Disease Ontology:DOID:10283); prostate carcinoma (Disease Ontology:DOID:10286); hypertension (Disease Ontology:DOID:10763); osteoporosis (Disease Ontology:DOID:11476); otosclerosis (Disease Ontology:DOID:12185); Marfan syndrome (Disease Ontology:DOID:14323); osteoarthritis (Disease Ontology:DOID:8398)", "pathway": " (mmu:12156); (R-MMU-201451); (R-MMU-2129379)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;14623234;15039429;15671031;15975920;16604073;17472960;17522060;1970330;23963447;24028588;29148101;29198724;31800957;8018727", "class_list": "", "function": "Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cardiogenesis, neurogenesis, and osteogenesis. Induces cartilage and bone formation. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Also acts to promote expression of HAMP, via the interaction with its receptor BMPR1A/ALK3 (PubMed:31800957). Can also signal through non-canonical pathways such as ERK/MAP kinase signaling cascade that regulates osteoblast differentiation. Also stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A-ATF4 pathway by stimulating EIF2A phosphorylation which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling (PubMed:29148101)., [UniProtKB, UniProtKB, PubMed, PubMed]; This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. While a homozygous knockout mouse for this gene exhibits embryonic lethality, conditional knockout mice have defects in bone, cartilage and heart development. [provided by RefSeq, Jul 2016]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9577, "biomarker_type": "", "glycan_count": 3, "disease_count": 12, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q497W8", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity;GO:0043539 protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005929 cilium;GO:0009986 cell surface", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:1901331 positive regulation of odontoblast differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0001934 positive regulation of protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P21274-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27038-1", "uniprot_id": [ { "id": "AVR2A_MOUSE", "url": "https://www.uniprot.org/uniprot/P27038", "type": "external" } ], "mass": 57890.0, "length": 513, "protein_name": "Activin receptor type-2A", "gene_name": "Acvr2a", "organism": "Mouse", "refseq_name": "activin receptor type-2A precursor", "refseq_ac": [ { "id": "NP_031422", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031422", "type": "external" } ], "gene_names_uniprotkb": "Acvr2a; Acvr2", "gene_names_refseq": "ActrIIa; Acvr2a; Acvr2; TactrII", "protein_names_uniprotkb": "Activin receptor type-2A; 2.7.11.30; ACTR-IIA; Activin receptor type IIA", "protein_names_refseq": "ACTR-IIA; activin receptor type IIA; activin receptor type-2A precursor", "tax_id": 10090, "disease": "juvenile polyposis syndrome (Disease Ontology:DOID:0050787); Marfan syndrome (Disease Ontology:DOID:14323); pancreatic cancer (Disease Ontology:DOID:1793); colon cancer (Disease Ontology:DOID:219); Lynch syndrome (Disease Ontology:DOID:3883); Weissenbacher-Zweymuller syndrome (Disease Ontology:DOID:4258); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (mmu:11480); (R-MMU-1502540); (R-MMU-201451); (R-MMU-9839406)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;10449041;10681527;1646080;23527555;25428506;35013323;37378449;37828378;8395525;9886286", "class_list": "", "function": "Activin A/ACVR2A axis inhibits epithelial-to-mesenchymal transition in colon cancer by activating SMAD2., [RefSeq, PubMed]; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6 (PubMed:23527555)., [UniProtKB, PubMed, PubMed, PubMed]; The m(6)A methyltransferase METTL3 regulates muscle maintenance and growth in mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9696, "biomarker_type": "", "glycan_count": 3, "disease_count": 7, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.11.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.30", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0015026 coreceptor activity;GO:0019838 growth factor binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0043235 receptor complex;GO:0048179 activin receptor complex", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0007283 spermatogenesis;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0008584 male gonad development;GO:0071363 cellular response to growth factor stimulus", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P27038-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64518-2", "uniprot_id": [ { "id": "AT2A3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64518", "type": "external" } ], "mass": 109530.0, "length": 999, "protein_name": "Sarcoplasmic/endoplasmic reticulum calcium ATPase 3", "gene_name": "Atp2a3", "organism": "Mouse", "refseq_name": "sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform c", "refseq_ac": [ { "id": "NP_001156809", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156809", "type": "external" } ], "gene_names_uniprotkb": "Atp2a3", "gene_names_refseq": "Atp2a3; SERCA3b; Serca3", "protein_names_uniprotkb": "Sarcoplasmic/endoplasmic reticulum calcium ATPase 3; 7.2.2.10; Calcium pump 3; SERCA3; SR Ca(2+)-ATPase 3", "protein_names_refseq": "SR Ca(2+)-ATPase 3; calcium pump 3; sarco /endoplasmic reticulum Ca2+ -ATPase; sarcoendoplasmic reticulum Ca2+ ATPase type 3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform c; sarcoplasmic/endoplasmic reticulum calcium ATPase 3", "tax_id": 10090, "disease": "Brody myopathy (Disease Ontology:DOID:0050692); hypertension (Disease Ontology:DOID:10763); heart disease (Disease Ontology:DOID:114)", "pathway": " (mmu:53313); (R-MMU-418359); (R-MMU-5578775); (R-MMU-936837)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "21183079;25428506;27301859;27923914;32152506;32588751;34428180;35469018;39627609;39927985;9593748", "class_list": "", "function": "NAADP/SERCA3-Dependent Ca(2+) Stores Pathway Specifically Controls Early Autocrine ADP Secretion Potentiating Platelet Activation., [RefSeq, PubMed]; SERCA3-dependent Ca(2+) stores control a specific ADP secretion pathway., [RefSeq, PubMed]; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen (PubMed:27923914). Contributes to calcium sequestration involved in muscular excitation/contraction., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O70625;Q64517;Q8VD16", "ec_number_list": [ { "id": "7.2.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.10", "type": "external" }, { "id": "7.2.2.8", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.8", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0005246 calcium channel regulator activity;GO:0016887 ATP hydrolysis activity;GO:0044325 transmembrane transporter binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0031090 organelle membrane;GO:0016529 sarcoplasmic reticulum;GO:0033017 sarcoplasmic reticulum membrane", "go_biological_process": "GO:0006874 intracellular calcium ion homeostasis;GO:0070588 calcium ion transmembrane transport;GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0032469 endoplasmic reticulum calcium ion homeostasis;GO:1903515 calcium ion transport from cytosol to endoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q64518-2", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q67FY2-1", "uniprot_id": [ { "id": "BCL9L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q67FY2", "type": "external" } ], "mass": 156680.0, "length": 1494, "protein_name": "B-cell CLL/lymphoma 9-like protein", "gene_name": "Bcl9l", "organism": "Mouse", "refseq_name": "B-cell CLL/lymphoma 9-like protein isoform 1", "refseq_ac": [ { "id": "NP_084532", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084532", "type": "external" } ], "gene_names_uniprotkb": "Bcl9l; B9l", "gene_names_refseq": "B9L; BCL9-2; Bcl9l; DLNB11", "protein_names_uniprotkb": "B-cell CLL/lymphoma 9-like protein; B-cell lymphoma 9-like protein; BCL9-like protein; BCL9-related beta-catenin-binding protein; Protein BCL9-2", "protein_names_refseq": "B-cell CLL/lymphoma 9-like protein isoform 1; B-cell CLL/lymphoma 9-like protein; B-cell lymphoma 9-like protein; BCL9-like protein; BCL9-related beta-catenin-binding protein; nuclear co-factor of beta-catenin signalling; protein BCL9-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:80288); (R-MMU-201722)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "15371335;15574752;17052462;17242355;21183079;21750661;23806337;24129315;31219806;32782141;36852467;38811552", "class_list": "", "function": "Targeting BCL9/BCL9L enhances antigen presentation by promoting conventional type 1 dendritic cell (cDC1) activation and tumor infiltration. Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1., [UniProtKB, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 21, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q641L9;Q6GQY0;Q6I7B5", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0001650 fibrillar center;GO:1990907 beta-catenin-TCF complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0060070 canonical Wnt signaling pathway;GO:0022604 regulation of cell morphogenesis;GO:0035914 skeletal muscle cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q67FY2-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99PV8-1", "uniprot_id": [ { "id": "BC11B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99PV8", "type": "external" } ], "mass": 94566.0, "length": 884, "protein_name": "B-cell lymphoma/leukemia 11B", "gene_name": "Bcl11b", "organism": "Mouse", "refseq_name": "B-cell lymphoma/leukemia 11B isoform a", "refseq_ac": [ { "id": "NP_001073352", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073352", "type": "external" } ], "gene_names_uniprotkb": "Bcl11b; Ctip2; Rit1", "gene_names_refseq": "9130430L19Rik; B630002E05Rik; BCL-11B; Bcl11b; Ctip2; Rit1", "protein_names_uniprotkb": "B-cell lymphoma/leukemia 11B; B-cell CLL/lymphoma 11B; BCL-11B; COUP-TF-interacting protein 2; Radiation-induced tumor suppressor gene 1 protein; mRit1", "protein_names_refseq": "B-cell CLL/lymphoma 11B; B-cell lymphoma/leukaemia 11B; B-cell lymphoma/leukemia 11B isoform a; B-cell lymphoma/leukemia 11B; COUP-TF-interacting protein 2; mRit1; radiation-induced tumor suppressor gene 1 protein", "tax_id": 10090, "disease": "specific developmental disorder (Disease Ontology:DOID:0060038); immunodeficiency 49 (Disease Ontology:DOID:0111979); neurodegenerative disease (Disease Ontology:DOID:1289); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:58208); (R-MMU-9933946); (R-MMU-9934037)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;10744719;12565905;12717433;12930829;16809611;21183079;21750661;23213215;24129315;25423098;34428180", "class_list": "", "function": "Bcl11b is a key regulator of both differentiation and survival during thymocyte development., [RefSeq, PubMed]; Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals (PubMed:12717433). Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (By similarity). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor protein involved in T-cell lymphomas. May function on the P53-signaling pathway. Repress transcription through direct, TFCOUP2-independent binding to a GC-rich response element., [UniProtKB, UniProtKB, PubMed, PubMed]; These results indicate that loss-of-function mutations of Rit1 contribute to mouse lymphomagenesis and possibly to human cancer development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 23, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C2I1;Q99PV6;Q99PV7;Q9JLF8", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016514 SWI/SNF complex;GO:0043005 neuron projection", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007409 axonogenesis;GO:0008285 negative regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q99PV8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D219-1", "uniprot_id": [ { "id": "BCL9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D219", "type": "external" } ], "mass": 148971.0, "length": 1425, "protein_name": "B-cell CLL/lymphoma 9 protein", "gene_name": "Bcl9", "organism": "Mouse", "refseq_name": "B-cell CLL/lymphoma 9 protein isoform 2", "refseq_ac": [ { "id": "NP_084209", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084209", "type": "external" } ], "gene_names_uniprotkb": "Bcl9", "gene_names_refseq": "2610202E01Rik; 8030475K17Rik; A330041G23Rik; Bcl9; Gm130", "protein_names_uniprotkb": "B-cell CLL/lymphoma 9 protein; B-cell lymphoma 9 protein; Bcl-9", "protein_names_refseq": "B-cell CLL/lymphoma 9 protein isoform 2; B-cell CLL/lymphoma 9 protein; B-cell lymphoma 9 protein; bcl-9; nuclear co-factor of beta-catenin signalling", "tax_id": 10090, "disease": "", "pathway": " (mmu:77578); (R-MMU-201722)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "15371335;17525332;19144319;22872234;23806337;24129315;25428506;30084848;30779550;34428180;35229987;35820727;36852467;38811552", "class_list": "", "function": "MiRNA-122-5p in POI ovarian-derived exosomes promotes granulosa cell apoptosis by regulating BCL9., [RefSeq, PubMed]; Promotes beta-catenin's transcriptional activity. Involved in signal transduction through the Wnt pathway (By similarity)., [UniProtKB, PubMed]; Targeting BCL9/BCL9L enhances antigen presentation by promoting conventional type 1 dendritic cell (cDC1) activation and tumor infiltration. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "B2RQC0;Q67FX9;Q8BUJ8;Q8VE74", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005801 cis-Golgi network;GO:1990907 beta-catenin-TCF complex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0060070 canonical Wnt signaling pathway;GO:0035914 skeletal muscle cell differentiation;GO:0035019 somatic stem cell population maintenance;GO:0014908 myotube differentiation involved in skeletal muscle regeneration", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9D219-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTZ8-1", "uniprot_id": [ { "id": "BEX2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WTZ8", "type": "external" } ], "mass": 15452.0, "length": 129, "protein_name": "Protein BEX2", "gene_name": "Bex2", "organism": "Mouse", "refseq_name": "protein BEX2", "refseq_ac": [ { "id": "NP_033879", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033879", "type": "external" } ], "gene_names_uniprotkb": "Bex2", "gene_names_refseq": "Bex1; Bex2; REX-3", "protein_names_uniprotkb": "Protein BEX2; Brain-expressed X-linked protein 2 homolog", "protein_names_refseq": "brain-expressed X-linked protein 1 homolog; brain-expressed X-linked protein 2 homolog; protein BEX1; protein BEX2; reduced expression protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:12069)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10072429;12911636;15198671;15861462;24129315;34562363", "class_list": "", "function": "Regulator of mitochondrial apoptosis and G1 cell cycle (By similarity). Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity (By similarity). In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (PubMed:34562363)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0046872 metal ion binding;GO:0035591 signaling adaptor activity;GO:0001223 transcription coactivator binding;GO:0140678 molecular function inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0007165 signal transduction;GO:0006915 apoptotic process;GO:0031397 negative regulation of protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9WTZ8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15116-1", "uniprot_id": [ { "id": "CADH2_MOUSE", "url": "https://www.uniprot.org/uniprot/P15116", "type": "external" } ], "mass": 99796.0, "length": 906, "protein_name": "Cadherin-2", "gene_name": "Cdh2", "organism": "Mouse", "refseq_name": "cadherin-2 preproprotein", "refseq_ac": [ { "id": "NP_031690", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031690", "type": "external" } ], "gene_names_uniprotkb": "Cdh2", "gene_names_refseq": "CDHN; Cdh2; N-CAD; Ncad", "protein_names_uniprotkb": "Cadherin-2; N-cadherin; Neural cadherin", "protein_names_refseq": "N-cadherin; cadherin-2 preproprotein; neural cadherin", "tax_id": 10090, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); agenesis of corpus callosum, cardiac, ocular, and genital syndrome (Disease Ontology:DOID:0080948); arrhythmogenic right ventricular dysplasia 14 (Disease Ontology:DOID:0080959); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094)", "pathway": " (mmu:12558); (R-MMU-381426); (R-MMU-418990); (R-MMU-525793); (R-MMU-8957275)", "pathway_count": 5, "publication_count": 32, "publication_id_list": "10.1101/2023.09.13.557529;11433297;1528849;15479741;17988630;19805319;21300292;21366346;21750661;23001562;23392350;24254198;24952463;25232112;25253890;25496840;26403541;26495903;26750727;2762814;28011936;30899004;31650526;32859226;33300544;34428180;34702855;34887587;37828378;7885471;8879495;9655503", "class_list": "", "function": "Cadherins are calcium-dependent cell adhesion proteins., [UniProtKB, UniProtKB]; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. Plays a role in cell-to-cell junction formation between pancreatic beta cells and neural crest stem (NCS) cells, promoting the formation of processes by NCS cells. Required for proper neurite branching. Required for pre- and postsynaptic organization. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. May promote axon outgrowth and motor fiber repair via DSP-mediated recruitment to outgrowth tips., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion. The encoded preproprotein undergoes proteolytic processing to generate a mature protein. Mice lacking the encoded protein exhibit severe developmental defects resulting in embryonic death. [provided by RefSeq, Oct 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 7, "reported_o_glycosites": 9, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 8, "total_reported_o_glycosites": 10, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 8, "total_o_glycosites": 10, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 13, "disease_count": 4, "glyco_site_count": 18, "binding_glycan_count": 0, "secondary_ac_list": "Q64260;Q6GU11", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0019899 enzyme binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005912 adherens junction", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0097091 synaptic vesicle clustering;GO:0007155 cell adhesion;GO:0016477 cell migration;GO:0043410 positive regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 6.4, "record_id": "P15116-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60865-1", "uniprot_id": [ { "id": "CAPR1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60865", "type": "external" } ], "mass": 78169.0, "length": 707, "protein_name": "Caprin-1", "gene_name": "Caprin1", "organism": "Mouse", "refseq_name": "caprin-1 isoform a", "refseq_ac": [ { "id": "NP_001104759", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104759", "type": "external" } ], "gene_names_uniprotkb": "Caprin1; G5E5; Gpiap1; Gpiap; Gpip137; M11s1; Rng105", "gene_names_refseq": "Caprin-1; Caprin1; Gpiap1; Gpiap; Mmgpip137; P137; rng105", "protein_names_uniprotkb": "Caprin-1; Cytoplasmic activation- and proliferation-associated protein 1; GPI-anchored membrane protein 1; GPI-anchored protein p137; GPI-p137; Membrane component chromosome 11 surface marker 1; RNA granule protein 105; p137GPI", "protein_names_refseq": "GPI-anchored membrane protein 1; GPI-anchored protein p137; GPI-p137; RNA granule protein 105; caprin-1 isoform a; cytoplasmic activation- and proliferation-associated protein 1; cytoplasmic activation/proliferation-associated protein 1; membrane component chromosome 11 surface marker 1; p137GPI", "tax_id": 10090, "disease": "", "pathway": " (mmu:53872)", "pathway_count": 1, "publication_count": 31, "publication_id_list": "14764709;16479539;17210633;20516077;21750661;22872234;24129315;25153642;25428506;26495903;28135057;28528544;29157358;29187734;30084848;31219806;32152506;33725478;34203471;34428180;34678516;34887587;35165318;35820727;36210013;36495875;37453647;39950214;40885482;40997131;8786113", "class_list": "", "function": "Overexpression of a fusion protein of enhanced green fluorescent protein and caprin-1 induces dose-dependent suppression of the proliferation of NIH-3T3 cells, consistent with the notion that caprin-1 plays a role in cellular activation or proliferation., [RefSeq, PubMed]; RNA degradation eliminates developmental transcripts during murine embryonic stem cell differentiation via CAPRIN1-XRN2., [RefSeq, PubMed]; Targeted deletion of the RNA-binding protein Caprin1 leads to progressive hearing loss and impairs recovery from noise exposure in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Thus, RNG105 has an essential role, as a key regulator of dendritic mRNA localization, in long-term memory formation. Publication Status: Online-Only, [RefSeq, PubMed]; mRNA-binding protein that acts as a regulator of mRNAs transport, translation and/or stability, and which is involved in neurogenesis, synaptic plasticity in neurons and cell proliferation and migration in multiple cell types (PubMed:20516077). Plays an essential role in cytoplasmic stress granule formation (By similarity). Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (By similarity). Undergoes liquid-liquid phase separation following phosphorylation and interaction with FMR1, promoting formation of cytoplasmic ribonucleoprotein granules that concentrate mRNAs with factors that inhibit translation and mediate deadenylation of target mRNAs (By similarity). In these cytoplasmic ribonucleoprotein granules, CAPRIN1 mediates recruitment of CNOT7 deadenylase, leading to mRNA deadenylation and degradation (By similarity). Binds directly and selectively to MYC and CCND2 mRNAs (By similarity). In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q60758;Q61620;Q6IMN3;Q7TT26", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0035591 signaling adaptor activity;GO:0140693 molecular condensate scaffold activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030027 lamellipodium;GO:0030425 dendrite", "go_biological_process": "GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:0007399 nervous system development;GO:0050808 synapse organization;GO:0007416 synapse assembly;GO:0017148 negative regulation of translation", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "Q60865-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08529-1", "uniprot_id": [ { "id": "CAN2_MOUSE", "url": "https://www.uniprot.org/uniprot/O08529", "type": "external" } ], "mass": 79872.0, "length": 700, "protein_name": "Calpain-2 catalytic subunit", "gene_name": "Capn2", "organism": "Mouse", "refseq_name": "calpain-2 catalytic subunit", "refseq_ac": [ { "id": "NP_033924", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033924", "type": "external" } ], "gene_names_uniprotkb": "Capn2", "gene_names_refseq": "CALP80; Capa-2; Capa2; Capn2; m-calpain; m-calpin", "protein_names_uniprotkb": "Calpain-2 catalytic subunit; 3.4.22.53; 80 kDa M-calpain subunit; CALP80; CANP 2; Calcium-activated neutral proteinase 2; Calpain M-type; Calpain-2 large subunit; M-calpain; Millimolar-calpain", "protein_names_refseq": "80 kDa M-calpain subunit; CANP 2; calcium-activated neutral proteinase 2; calpain M-type; calpain-2 catalytic subunit; calpain-2 large subunit; cysteine proteinase; m-calpain 80 kDa large subunit; m-calpain large subunit; millimolar-calpain", "tax_id": 10090, "disease": "traumatic brain injury (Disease Ontology:DOID:0081292); hereditary spastic paraplegia 76 (Disease Ontology:DOID:0110821); intellectual disability (Disease Ontology:DOID:1059); Alzheimer's disease (Disease Ontology:DOID:10652); sciatic neuropathy (Disease Ontology:DOID:11446); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); hereditary spastic paraplegia (Disease Ontology:DOID:2476); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:12334); (R-MMU-1474228); (R-MMU-9856530); (R-MMU-9860927)", "pathway_count": 4, "publication_count": 15, "publication_id_list": "22645316;22711986;24788674;25153642;31219806;34428180;34887587;35606145;35820727;36210013;37507081;38305737;38960317;9339374;9669314", "class_list": "", "function": "Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226' (By similarity). Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs (PubMed:22711986)., [UniProtKB, UniProtKB, PubMed]; Calpain-2 Mediates MBNL2 Degradation and a Developmental RNA Processing Program in Neurodegeneration., [RefSeq, PubMed]; Targeting calpain-2-mediated junctophilin-2 cleavage delays heart failure progression following myocardial infarction., [RefSeq, PubMed]; The neuronal transcription factor MEIS2 is a calpain-2 protease target., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35518;O54843", "ec_number_list": [ { "id": "3.4.22.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.53", "type": "external" }, { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.22.54", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.54", "type": "external" } ], "go_molecular_function": "GO:0004198 calcium-dependent cysteine-type endopeptidase activity;GO:0019899 enzyme binding;GO:0005509 calcium ion binding;GO:0044877 protein-containing complex binding;GO:0008092 cytoskeletal protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0001666 response to hypoxia;GO:0042542 response to hydrogen peroxide;GO:0071222 cellular response to lipopolysaccharide;GO:0007565 female pregnancy", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "O08529-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55288-1", "uniprot_id": [ { "id": "CAD11_MOUSE", "url": "https://www.uniprot.org/uniprot/P55288", "type": "external" } ], "mass": 88112.0, "length": 796, "protein_name": "Cadherin-11", "gene_name": "Cdh11", "organism": "Mouse", "refseq_name": "cadherin-11 preproprotein", "refseq_ac": [ { "id": "NP_033996", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033996", "type": "external" } ], "gene_names_uniprotkb": "Cdh11; Cad-11", "gene_names_refseq": "Cad11; Cdh11; OSF-4", "protein_names_uniprotkb": "Cadherin-11; OB-cadherin; OSF-4; Osteoblast cadherin", "protein_names_refseq": "OB-cadherin; cadherin-11 preproprotein; osteoblast cadherin", "tax_id": 10090, "disease": "Elsahy-Waters syndrome (Disease Ontology:DOID:0080631); Teebi hypertelorism syndrome 2 (Disease Ontology:DOID:0081074)", "pathway": " (mmu:12552); (R-MMU-418990); (R-MMU-9762292); (R-MMU-9958825)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;21183079;30899004;37171723;38447248;7750649;7750650;8163513;8879495", "class_list": "", "function": "CADHERIN-11 regulation of myeloid phagocytes and autoimmune inflammation in murine lupus., [RefSeq, PubMed]; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Required for proper focal adhesion assembly. Involved in the regulation of cell migration., [UniProtKB, UniProtKB]; Let-7c-3p suppresses lens epithelial-mesenchymal transition by inhibiting cadherin-11 expression in fibrotic cataract., [RefSeq, PubMed]; This gene encodes a type II classical cadherin and preproprotein that is proteolytically processed to generate a mature protein product. This protein product is an integral membrane protein that mediates calcium-dependent cell-cell adhesion, specifically in the context of bone development. Homozygous knockout mice for this gene exhibit impaired synovium development and reduced bone density. Multiple pseudogenes of this gene have been identified in the genome. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 7, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0045202 synapse", "go_biological_process": "GO:0016477 cell migration;GO:0030336 negative regulation of cell migration;GO:0000902 cell morphogenesis;GO:0048041 focal adhesion assembly;GO:0050804 modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P55288-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31001-1", "uniprot_id": [ { "id": "DESM_MOUSE", "url": "https://www.uniprot.org/uniprot/P31001", "type": "external" } ], "mass": 53498.0, "length": 469, "protein_name": "Desmin", "gene_name": "Des", "organism": "Mouse", "refseq_name": "desmin", "refseq_ac": [ { "id": "NP_034173", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034173", "type": "external" } ], "gene_names_uniprotkb": "Des", "gene_names_refseq": "Des", "protein_names_uniprotkb": "Desmin", "protein_names_refseq": "desmin", "tax_id": 10090, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); cardiomyopathy (Disease Ontology:DOID:0050700); myofibrillar myopathy 1 (Disease Ontology:DOID:0080092); dilated cardiomyopathy 1I (Disease Ontology:DOID:0110431); neurogenic scapuloperoneal syndrome Kaeser type (Disease Ontology:DOID:0111551); dilated cardiomyopathy (Disease Ontology:DOID:12930); restrictive cardiomyopathy (Disease Ontology:DOID:397); mitral valve prolapse (Disease Ontology:DOID:988)", "pathway": " (mmu:13346); (R-MMU-390522)", "pathway_count": 2, "publication_count": 27, "publication_id_list": "10357897;10852826;17242355;21183079;24129315;24940650;25394388;25733715;26343497;26787680;27102488;27301331;27565725;27733623;28469177;30016717;30084848;30779550;32042098;34428180;35959657;36288343;37126682;37507081;39927985;8120103;8382796", "class_list": "", "function": "Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (By similarity). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:25394388). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction (PubMed:27102488). Required for nuclear membrane integrity, via anchoring at the cell tip and nuclear envelope, resulting in maintenance of microtubule-derived intracellular mechanical forces (PubMed:35959657). Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (PubMed:27733623)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]; This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane and are essential for maintaining the strength and integrity of skeletal, cardiac and smooth muscle fibers. Mutations in this gene affect assembly of intermediate filaments. Mice lacking this gene are able to develop and reproduce but exhibit abnormal muscle fibers. Mutations in the human gene are associated with myofibrillar myopathy, dilated cardiomyopathy, neurogenic scapuloperoneal syndrome and autosomal recessive limb-girdle muscular dystrophy, type 2R. [provided by RefSeq, Jan 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 17, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0042802 identical protein binding;GO:0008092 cytoskeletal protein binding", "go_cellular_component": "GO:0051286 cell tip;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005856 cytoskeleton", "go_biological_process": "GO:0060538 skeletal muscle organ development;GO:0007517 muscle organ development;GO:0045109 intermediate filament organization;GO:0006998 nuclear envelope organization", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P31001-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91VN6-1", "uniprot_id": [ { "id": "DDX41_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91VN6", "type": "external" } ], "mass": 69820.0, "length": 622, "protein_name": "Probable ATP-dependent RNA helicase DDX41", "gene_name": "Ddx41", "organism": "Mouse", "refseq_name": "probable ATP-dependent RNA helicase DDX41", "refseq_ac": [ { "id": "NP_598820", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598820", "type": "external" } ], "gene_names_uniprotkb": "Ddx41", "gene_names_refseq": "2900024F02Rik; ABS; Ddx41", "protein_names_uniprotkb": "Probable ATP-dependent RNA helicase DDX41; 3.6.4.13; DEAD box protein 41", "protein_names_refseq": "DEAD (Asp-Glu-Ala-Asp) box polypeptide 41; DEAD box protein 41; DEAD-box protein abstrakt; probable ATP-dependent RNA helicase DDX41", "tax_id": 10090, "disease": "myeloproliferative neoplasm (Disease Ontology:DOID:2226)", "pathway": " (mmu:72935); (R-MMU-1834941); (R-MMU-3134975); (R-MMU-72163)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "17242355;21183079;21892174;23222971;29871919;31219806;34428180;35303436;38937548", "class_list": "", "function": "DDX41 haploinsufficiency causes inefficient hematopoiesis under stress and cooperates with p53 mutations to cause hematologic malignancy., [RefSeq, PubMed]; DDX41 is an additional DNA sensor that depends on STING to sense pathogenic DNA. Erratum:[Nat Immunol. 2012 Feb;13(2):196] Publication Status: Online-Only, [RefSeq, PubMed]; Multifunctional protein that participates in many aspects of cellular RNA metabolism. Plays pivotal roles in innate immune sensing and hematopoietic homeostasis (PubMed:35303436). Recognizes foreign or self-nucleic acids generated during microbial infection, thereby initiating anti-pathogen responses. Mechanistically, phosphorylation by BTK allows binding to dsDNA leading to interaction with STING1. Modulates the homeostasis of dsDNA through its ATP-dependent DNA-unwinding activity and ATP-independent strand-annealing activity. In turn, induces STING1-mediated type I interferon and cytokine responses to DNA and DNA viruses (PubMed:21892174). During murine leukemia virus infection, primarily senses the DNA/RNA hybrid generated at the first step of reverse transcription, while cGAS recognizes dsDNA generated at the next step and both are needed for the antiretroviral innate immune response (PubMed:29871919). Selectively modulates the transcription of certain immunity-associated genes by regulating their alternative splicing. Binds to RNA (R)-loops, structures consisting of DNA/RNA hybrids and a displaced strand of DNA that occur during transcription, and prevents their accumulation, thereby maintaining genome stability. Also participates in pre-mRNA splicing, translational regulation and snoRNA processing, which is essential for ribosome biogenesis., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; TRIM21 is an interferon-inducible E3 ligase that induces the Lys48-linked ubiquitination and degradation of DDX41 and negatively regulates the innate immune response to intracellular double-stranded DNA., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U0E0", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0008283 cell population proliferation;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051607 defense response to virus;GO:0035458 cellular response to interferon-beta", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q91VN6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QY15-1", "uniprot_id": [ { "id": "DDX25_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QY15", "type": "external" } ], "mass": 54876.0, "length": 484, "protein_name": "ATP-dependent RNA helicase DDX25", "gene_name": "Ddx25", "organism": "Mouse", "refseq_name": "ATP-dependent RNA helicase DDX25", "refseq_ac": [ { "id": "NP_038960", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038960", "type": "external" } ], "gene_names_uniprotkb": "Ddx25; Grth", "gene_names_refseq": "Ddx25; GRTH", "protein_names_uniprotkb": "ATP-dependent RNA helicase DDX25; 3.6.4.13; DEAD box protein 25; Gonadotropin-regulated testicular RNA helicase", "protein_names_refseq": "ATP-dependent RNA helicase DDX25; DEAD (Asp-Glu-Ala-Asp) box polypeptide 25; DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 25; DEAD box protein 25; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 25; gonadotropin-regulated testicular RNA helicase", "tax_id": 10090, "disease": "", "pathway": " (mmu:30959)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10608860;15096601;16968703;18430733;21183079;31219806;32665638;36834539;36899892", "class_list": "", "function": "ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development., [UniProtKB, PubMed]; Demonstrates that GRTH is essential for completion of spermatogenesis, (ii) provides insights into intrinsic requirements for spermiogenesis, and (iii) establishes a model for studies of male infertility and contraception, [RefSeq, PubMed]; GRTH, as a component of mRNP particles, acts as a negative regulator of the tumor necrosis factor receptor 1 and caspase pathways and promotes NF-kappaB function to control apoptosis in spermatocytes of adult mice, [RefSeq, PubMed]; MiRNA Expression Profiles of Mouse Round Spermatids in GRTH/DDX25-Mediated Spermiogenesis: mRNA-miRNA Network Analysis. Publication Status: Online-Only, [RefSeq, PubMed]; Single-Cell Transcriptomic Profiling of the Mouse Testicular Germ Cells Reveals Important Role of Phosphorylated GRTH/DDX25 in Round Spermatid Differentiation and Acrosome Biogenesis during Spermiogenesis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q53Z03;Q7TMB5;Q8R1B6", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0010494 cytoplasmic stress granule;GO:0033391 chromatoid body", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0006406 mRNA export from nucleus;GO:0006417 regulation of translation;GO:0007286 spermatid development", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9QY15-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q8T7-1", "uniprot_id": [ { "id": "DYH1_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q8T7", "type": "external" } ], "mass": 487070.0, "length": 4250, "protein_name": "Dynein axonemal heavy chain 1", "gene_name": "Dnah1", "organism": "Mouse", "refseq_name": "dynein axonemal heavy chain 1", "refseq_ac": [ { "id": "NP_001028840", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028840", "type": "external" } ], "gene_names_uniprotkb": "Dnah1; Dhc7; Dnahc1", "gene_names_refseq": "B230373P09Rik; Dnah1; Dnahc1; E030034C22Rik; G1-415-19; MDHC7; ferf1", "protein_names_uniprotkb": "Dynein axonemal heavy chain 1; Axonemal beta dynein heavy chain 1; Ciliary dynein heavy chain 1; mDHC7", "protein_names_refseq": "axonemal beta dynein heavy chain 1; ciliary dynein heavy chain 1; dynein axonemal heavy chain 1; dynein heavy chain 1, axonemal; dynein, axon, heavy chain 1; dynein, axonemal, heavy polypeptide 1", "tax_id": 10090, "disease": "spermatogenic failure 18 (Disease Ontology:DOID:0070165); primary ciliary dyskinesia 37 (Disease Ontology:DOID:0080266)", "pathway": " (mmu:110084)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11371505;15455100;25428506;35820727;9373155", "class_list": "", "function": "Force generating protein of cilia required for sperm flagellum motility (PubMed:11371505). Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity). Required in spermatozoa for the formation of the inner dynein arms and biogenesis of the axoneme (By similarity)., [UniProtKB, PubMed, UniProtKB]; Results could find no significant differences or typical disorders in the outer or inner dynein arms of mice deficient in dynein heavy chains., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "O08828;Q8R584", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0003777 microtubule motor activity;GO:0008569 minus-end-directed microtubule motor activity;GO:0051959 dynein light intermediate chain binding;GO:0045505 dynein intermediate chain binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005874 microtubule;GO:0036126 sperm flagellum;GO:0005930 axoneme;GO:0030286 dynein complex", "go_biological_process": "GO:0060294 cilium movement involved in cell motility;GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0030317 flagellated sperm motility;GO:0007288 sperm axoneme assembly;GO:0036159 inner dynein arm assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "E9Q8T7-1", "record_type": "protein", "filter_code": "0000000.1000111.001000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QUM4-1", "uniprot_id": [ { "id": "SLAF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QUM4", "type": "external" } ], "mass": 38094.0, "length": 343, "protein_name": "Signaling lymphocytic activation molecule", "gene_name": "Slamf1", "organism": "Mouse", "refseq_name": "signaling lymphocytic activation molecule isoform 1 precursor", "refseq_ac": [ { "id": "NP_038758", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038758", "type": "external" } ], "gene_names_uniprotkb": "Slamf1; Slam", "gene_names_refseq": "4933415F16; CD150; CDw150; ESTM51; IPO-3; Slamf1; Slam", "protein_names_uniprotkb": "Signaling lymphocytic activation molecule; SLAM family member 1", "protein_names_refseq": "SLAM family member 1; signaling lymphocyte activation molecule; signaling lymphocytic activation molecule isoform 1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:27218)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10570270;11477403;11689425;12351401;15123745;15315965;15539155;16528012;16847311;18031695;18606638;20525889;20818396;22493499;25926831;29187734;35217584;36110846;9126961;9774102", "class_list": "", "function": "(Microbial infection) Involved in innate immune response against Gram-negative bacteria in macrophages; probably recognizes OmpC and/or OmpF on the bacterial surface, regulates phagosome maturation and recruitment of the PI3K complex II (PI3KC3-C2) leading to accumulated of PdtIns(3)P and NOX2 activity in the phagosomes (PubMed:20818396, PubMed:22493499)., [UniProtKB, PubMed, PubMed]; Identification of SLAMF1 as an immune-related key gene associated with rheumatoid arthritis and verified in mice collagen-induced arthritis model. Publication Status: Online-Only, [RefSeq, PubMed]; SLAMF1 Is Dispensable for Vaccine-Induced T Cell Development but Required for Resistance to Fungal Infection., [RefSeq, PubMed]; Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. SLAMF1-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAMF1 signaling seem to exist: one depending on SH2D1A (and perhaps SH2D1B) and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates. Initially it has been proposed that association with SH2D1A prevents binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2 (By similarity). However, signaling is also regulated by SH2D1A which can simultaneously interact with and recruit FYN which subsequently phosphorylates and activates SLAMF1 (By similarity). Mediates IL-2-independent proliferation of activated T-cells during immune responses and induces IFN-gamma production (PubMed:12351401, PubMed:9126961). Downstreaming signaling involves INPP5D, DOK1 and DOK2 leading to inhibited IFN-gamma production in T-cells, and PRKCQ, BCL10 and NFKB1 leading to increased T-cell activation and Th2 cytokine production (PubMed:11477403, PubMed:15539155, PubMed:16847311). Promotes T-cell receptor-induced IL-4 secretion by CD4(+) cells (PubMed:15123745). Inhibits antigen receptor-mediated production of IFN-gamma, but not IL-2, in CD4(-)/CD8(-) T-cells (PubMed:11477403). Required for IL-4 production by germinal centers T follicular helper (T(Fh))cells (PubMed:20525889). May inhibit CD40-induced signal transduction in monocyte-derived dendritic cells (By similarity). May play a role in allergic responses and may regulate allergen-induced Th2 cytokine and Th1 cytokine secretion (PubMed:16528012). In conjunction with SLAMF6 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage (PubMed:18031695). Involved in the peripheral differentiation of indifferent natural killer T (iNKT) cells toward a regulatory NKT2 type (PubMed:18606638). In macrophages involved in down-regulation of IL-12, TNF and nitric oxide in response to lipopolysaccharide (LPS) (PubMed:15123745). In B-cells activates the ERK signaling pathway independently of SH2D1A but implicating both, SYK and INPP5D, and activates Akt signaling dependent on SYK and SH2D1A (PubMed:15315965). In conjunction with CD84/SLAMF5 and SLAMF6 may be a negative regulator of the humoral immune response (PubMed:25926831)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q9QXZ3", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042169 SH2 domain binding;GO:0001618 virus receptor activity;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane;GO:0045335 phagocytic vesicle", "go_biological_process": "GO:0001779 natural killer cell differentiation;GO:0002725 negative regulation of T cell cytokine production;GO:0006955 immune response;GO:0007155 cell adhesion;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q9QUM4-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.0100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q923J1-1", "uniprot_id": [ { "id": "TRPM7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q923J1", "type": "external" } ], "mass": 212399.0, "length": 1863, "protein_name": "Transient receptor potential cation channel subfamily M member 7", "gene_name": "Trpm7", "organism": "Mouse", "refseq_name": "transient receptor potential cation channel subfamily M member 7 isoform 2", "refseq_ac": [ { "id": "NP_001157797", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157797", "type": "external" } ], "gene_names_uniprotkb": "Trpm7; Chak; Ltrpc7", "gene_names_refseq": "2310022G15Rik; 4833414K03Rik; 5033407O22Rik; CHAK1; CHAK; LTrpC-7; Ltpr7; Ltrpc7; TRPPLIK; Trpm7", "protein_names_uniprotkb": "Transient receptor potential cation channel subfamily M member 7; 2.7.11.1; Channel-kinase 1; LTrpC-7; LTrpC7; Long transient receptor potential channel 7; TRP-PLIK; Transient receptor potential-phospholipase C-interacting kinase", "protein_names_refseq": "channel-kinase 1; long transient receptor potential channel 7; transient receptor potential M7; transient receptor potential cation channel subfamily M member 7 isoform 2; transient receptor potential-phospholipase C-interacting kinase; transient receptor potential-related protein, ChaK", "tax_id": 10090, "disease": "sinoatrial node disease (Disease Ontology:DOID:0050824); MASA syndrome (Disease Ontology:DOID:0060246); chromosome 15q13.3 microdeletion syndrome (Disease Ontology:DOID:0060394); amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 (Disease Ontology:DOID:0111246)", "pathway": " (mmu:58800); (R-MMU-3295583)", "pathway_count": 2, "publication_count": 30, "publication_id_list": "11161216;11385574;11389851;12508053;16260839;18974357;19144319;21045827;21183079;21750661;22203997;22222377;22698280;23878236;24855944;25030553;25605945;28696294;28821869;29203869;29343440;30108148;30770447;31219806;34428180;34686339;35389104;35820727;36210013;37156763", "class_list": "", "function": "Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11161216, PubMed:11385574, PubMed:28696294, PubMed:29343440). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (PubMed:18974357, PubMed:21045827, PubMed:22203997, PubMed:23878236, PubMed:28696294, PubMed:29203869, PubMed:29343440, PubMed:30770447). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:22222377). TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways (PubMed:29203869). In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development., [UniProtKB, PubMed, PubMed]; The Trpm7 ion channel possesses the unique ability to efficiently conduct many essential trace metal ions such as Zn2+, Fe2+, Cu2+, Mn2+, and Co2+ into cells, along with several toxic metal ions such as Cd2+, Ba2+, and Sr2+ as well., [RefSeq, PubMed]; The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 45, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AI58;Q8C7S7;Q8CE54;Q921Y5;Q925B2;Q9CUT2;Q9JLQ1", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0003779 actin binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005262 calcium channel activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0043025 neuronal cell body;GO:0031410 cytoplasmic vesicle;GO:0030672 synaptic vesicle membrane", "go_biological_process": "GO:0015693 magnesium ion transport;GO:0006829 zinc ion transport;GO:1903830 magnesium ion transmembrane transport;GO:0006468 protein phosphorylation;GO:0007613 memory", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "Q923J1-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "K7N6G4-1", "uniprot_id": [ { "id": "K7N6G4_MOUSE", "url": "https://www.uniprot.org/uniprot/K7N6G4", "type": "external" } ], "mass": 24217.0, "length": 205, "protein_name": "Predicted gene 16434; Predicted gene 6676", "gene_name": "Gm16434", "organism": "Mouse", "refseq_name": "uncharacterized protein Gm16434", "refseq_ac": [ { "id": "XP_011243125", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_011243125", "type": "external" } ], "gene_names_uniprotkb": "Gm16434; Gm6676", "gene_names_refseq": "Gm16434", "protein_names_uniprotkb": "Predicted gene 16434; Predicted gene 6676", "protein_names_refseq": "uncharacterized protein Gm16434", "tax_id": 10090, "disease": "", "pathway": " (mmu:100042182); (mmu:105245673)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "K7N6G4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D5T0-1", "uniprot_id": [ { "id": "ATAD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D5T0", "type": "external" } ], "mass": 40744.0, "length": 361, "protein_name": "Outer mitochondrial transmembrane helix translocase", "gene_name": "Atad1", "organism": "Mouse", "refseq_name": "outer mitochondrial transmembrane helix translocase", "refseq_ac": [ { "id": "NP_080763", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080763", "type": "external" } ], "gene_names_uniprotkb": "Atad1", "gene_names_refseq": "4921525H23Rik; Atad1; Thorase", "protein_names_uniprotkb": "Outer mitochondrial transmembrane helix translocase; 7.4.2.-; ATPase family AAA domain-containing protein 1; Thorase", "protein_names_refseq": "ATPase family AAA domain-containing protein 1; outer mitochondrial transmembrane helix translocase", "tax_id": 10090, "disease": "hyperekplexia 4 (Disease Ontology:DOID:0080581)", "pathway": " (mmu:67979); (R-MMU-9603798)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;17208939;17242355;17768142;21496646;21750661;24843043;28135057;28528544;30899004;33300544;34428180;37626842", "class_list": "", "function": "Genetic Deletion of Thorase Causes Purkinje Cell Loss and Impaired Motor Coordination Behavior. Publication Status: Online-Only, [RefSeq, PubMed]; Outer mitochondrial translocase required to remove mislocalized tail-anchored transmembrane proteins on mitochondria (By similarity). Specifically recognizes and binds tail-anchored transmembrane proteins: acts as a dislocase that mediates the ATP-dependent extraction of mistargeted tail-anchored transmembrane proteins from the mitochondrion outer membrane (By similarity). Also plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory (PubMed:21496646). Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (PubMed:21496646)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Yeast Msp1 and mammalian ATAD1 are conserved members of the mitochondrial protein quality control system that might promote the extraction and degradation of mislocalized TA proteins to maintain mitochondrial integrity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U8V2;Q9D7A4", "ec_number_list": [ { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "1.2.1.94", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.94", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "7.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.4.2.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0140567 membrane protein dislocase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005778 peroxisomal membrane;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0007612 learning;GO:0007613 memory;GO:0051967 negative regulation of synaptic transmission, glutamatergic;GO:0002092 positive regulation of receptor internalization;GO:0099149 regulation of postsynaptic neurotransmitter receptor internalization", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9D5T0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U182-1", "uniprot_id": [ { "id": "CRTC2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U182", "type": "external" } ], "mass": 73216.0, "length": 692, "protein_name": "CREB-regulated transcription coactivator 2", "gene_name": "Crtc2", "organism": "Mouse", "refseq_name": "CREB-regulated transcription coactivator 2 isoform 1", "refseq_ac": [ { "id": "NP_083157", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083157", "type": "external" } ], "gene_names_uniprotkb": "Crtc2; Torc2", "gene_names_refseq": "4632407F12Rik; Crtc2; Torc2", "protein_names_uniprotkb": "CREB-regulated transcription coactivator 2; TORC-2; Transducer of CREB protein 2; Transducer of regulated cAMP response element-binding protein 2", "protein_names_refseq": "CREB-regulated transcription coactivator 2 isoform 1; TORC-2; transducer of CREB protein 2; transducer of regulated cAMP response element-binding protein 2", "tax_id": 10090, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:74343)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "16148943;16308421;16684769;17242355;17805301;18323454;19144319;20551288;21183079;21750661;23699513;24129315;24570487;25088745;27239959;28235073;28589878;29211348;30232001;30337688;30611118;33434948;38878857", "class_list": "", "function": "Hepatic noradrenergic innervation acts via CREB/CRTC2 to activate gluconeogenesis during cold., [RefSeq, PubMed]; Hormonal and energy-sensing pathways converge on the coactivator TORC2 (transducer of regulated CREB activity 2) to modulate glucose output, [RefSeq, PubMed]; Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites (PubMed:29211348). Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated (PubMed:29211348). Acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 24, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q3TA52;Q8BH09", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0008140 cAMP response element binding protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051289 protein homotetramerization;GO:0071320 cellular response to cAMP;GO:0006094 gluconeogenesis", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "Q3U182-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35696-1", "uniprot_id": [ { "id": "SIA8B_MOUSE", "url": "https://www.uniprot.org/uniprot/O35696", "type": "external" } ], "mass": 42411.0, "length": 375, "protein_name": "Alpha-2,8-sialyltransferase 8B", "gene_name": "St8sia2", "organism": "Mouse", "refseq_name": "alpha-2,8-sialyltransferase 8B isoform 1 precursor", "refseq_ac": [ { "id": "NP_033207", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033207", "type": "external" } ], "gene_names_uniprotkb": "St8sia2; Siat8b; Stx", "gene_names_refseq": "ST8SiaII; STX; Siat8b; St8sia2", "protein_names_uniprotkb": "Alpha-2,8-sialyltransferase 8B; 2.4.3.-; Polysialic acid synthase; SIAT8-B; ST8SiaII; STX; Sialyltransferase 8B; Sialyltransferase St8Sia II; Sialyltransferase X", "protein_names_refseq": "SIAT8-B; alpha-2,8-sialyltransferase 8B isoform 1 precursor; alpha-2,8-sialyltransferase 8B; polysialic acid synthase; sialyltransferase 8 (alpha-2, 8-sialyltransferase) B; sialyltransferase St8Sia II; sialyltransferase X; sialytransferase St8Sia II", "tax_id": 10090, "disease": "", "pathway": " (mmu:20450); (R-MMU-4085001); (R-MMU-419037); (R-MMU-975577)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;21750661;27534376;31599954;35115485;7875291;8939967", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the transfer of a sialic acid from a CMP-linked sialic acid donor onto a terminal alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid of an N-linked glycan acceptor through alpha-2,8-linkages (PubMed:7875291). Therefore, participates in polysialic acid synthesis on various sialylated N-acetyllactosaminyl oligosaccharides (alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid), including NCAM1, NCAM1 N-glycans, FETUB N-glycans, and to a lesser extent sialylparagloboside (SPG) and AHSG, which does not require the initial addition of an alpha 2,8-sialic acid (By similarity). However, does not exhibit sialic acid-polymerase activity (PubMed:7875291). Catalyzes polysialic acid synthesis in the hippocampal on NCAM1 and supports neurite outgrowth (PubMed:7875291). ST8SIA2-mediated polysialylation influences on oligodendrocyte differentiation and may promote the integrity of myelin and axons (PubMed:27534376)., [UniProtKB, UniProtKB, PubMed, PubMed]; Compromised mammillary body connectivity and psychotic symptoms in mice with di- and mesencephalic ablation of ST8SIA2. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 21, "reported_interactions": 0, "missing_score": 9462, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q4VA47", "ec_number_list": [ { "id": "2.4.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.-", "type": "external" }, { "id": "2.4.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.-", "type": "external" }, { "id": "2.4.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.8", "type": "external" } ], "go_molecular_function": "GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity;GO:0000166 nucleotide binding;GO:0008373 sialyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005654 nucleoplasm;GO:0005769 early endosome;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0042220 response to cocaine;GO:0051965 positive regulation of synapse assembly;GO:0043525 positive regulation of neuron apoptotic process;GO:0009311 oligosaccharide metabolic process", "synthesized_glycan_count": 21, "hit_score": 1.4, "record_id": "O35696-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000010000.101.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P25446-1", "uniprot_id": [ { "id": "TNR6_MOUSE", "url": "https://www.uniprot.org/uniprot/P25446", "type": "external" } ], "mass": 37437.0, "length": 327, "protein_name": "Tumor necrosis factor receptor superfamily member 6", "gene_name": "Fas", "organism": "Mouse", "refseq_name": "tumor necrosis factor receptor superfamily member 6 isoform 1 precursor", "refseq_ac": [ { "id": "NP_032013", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032013", "type": "external" } ], "gene_names_uniprotkb": "Fas; Apt1; Tnfrsf6", "gene_names_refseq": "APO1; APT1; CD95; Fas; TNFR6; Tnfrsf6; lpr", "protein_names_uniprotkb": "Tumor necrosis factor receptor superfamily member 6; Apo-1 antigen; Apoptosis-mediating surface antigen FAS; FASLG receptor", "protein_names_refseq": "FASLG receptor; Fas (TNF receptor superfamily member 6); Fas (TNF receptor superfamily member); Fas antigen; apo-1 antigen; apoptosis-mediating surface antigen FAS; lymphoproliferation; tumor necrosis factor receptor superfamily member 6 isoform 1 precursor", "tax_id": 10090, "disease": "adult T-cell leukemia/lymphoma (Disease Ontology:DOID:0050523); chorioamnionitis (Disease Ontology:DOID:0050697); myelodysplastic syndrome (Disease Ontology:DOID:0050908); pre-malignant neoplasm (Disease Ontology:DOID:0060071); brain glioma (Disease Ontology:DOID:0060108); lymphoproliferative syndrome (Disease Ontology:DOID:0060704); alcohol-associated liver disease (Disease Ontology:DOID:0070658); nasal type extranodal NK/T-cell lymphoma (Disease Ontology:DOID:0080797); graft-versus-host disease (Disease Ontology:DOID:0081267); dermatomyositis (Disease Ontology:DOID:10223); prostate cancer (Disease Ontology:DOID:10283); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); gastric ulcer (Disease Ontology:DOID:10808); urinary bladder cancer (Disease Ontology:DOID:11054); cryptorchidism (Disease Ontology:DOID:11383); sciatic neuropathy (Disease Ontology:DOID:11446); diabetic angiopathy (Disease Ontology:DOID:11713); primary biliary cholangitis (Disease Ontology:DOID:12236); male infertility (Disease Ontology:DOID:12336); varicocele (Disease Ontology:DOID:12337); alcoholic hepatitis (Disease Ontology:DOID:12351); Graves' disease (Disease Ontology:DOID:12361); aplastic anemia (Disease Ontology:DOID:12449); Huntington's disease (Disease Ontology:DOID:12858); Sjogren's syndrome (Disease Ontology:DOID:12894); dilated cardiomyopathy (Disease Ontology:DOID:12930); HELLP syndrome (Disease Ontology:DOID:13133); Behcet's disease (Disease Ontology:DOID:13241); clonorchiasis (Disease Ontology:DOID:13767); abdominal obesity-metabolic syndrome 1 (Disease Ontology:DOID:14221); Parkinson's disease (Disease Ontology:DOID:14330); cystic fibrosis (Disease Ontology:DOID:1485); breast cancer (Disease Ontology:DOID:1612); glaucoma (Disease Ontology:DOID:1686); melanoma (Disease Ontology:DOID:1909); atherosclerosis (Disease Ontology:DOID:1936); hepatitis B (Disease Ontology:DOID:2043); autoimmune hepatitis (Disease Ontology:DOID:2048); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); multiple sclerosis (Disease Ontology:DOID:2377); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); ovarian cancer (Disease Ontology:DOID:2394); chronic conjunctivitis (Disease Ontology:DOID:2475); transitional cell carcinoma (Disease Ontology:DOID:2671); asthma (Disease Ontology:DOID:2841); IgA glomerulonephritis (Disease Ontology:DOID:2986); acute kidney failure (Disease Ontology:DOID:3021); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); peripheral vascular disease (Disease Ontology:DOID:341); inclusion body myositis (Disease Ontology:DOID:3429); breast carcinoma (Disease Ontology:DOID:3459); mixed connective tissue disease (Disease Ontology:DOID:3492); lung adenocarcinoma (Disease Ontology:DOID:3910); liver disease (Disease Ontology:DOID:409); myasthenia gravis (Disease Ontology:DOID:437); seminoma (Disease Ontology:DOID:4440); macular degeneration (Disease Ontology:DOID:4448); renal cell carcinoma (Disease Ontology:DOID:4450); endophthalmitis (Disease Ontology:DOID:4692); multiple system atrophy (Disease Ontology:DOID:4752); esophagus adenocarcinoma (Disease Ontology:DOID:4914); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); retinal detachment (Disease Ontology:DOID:5327); congestive heart failure (Disease Ontology:DOID:6000); autoimmune lymphoproliferative syndrome (Disease Ontology:DOID:6688); hepatocellular carcinoma (Disease Ontology:DOID:684); hepatoblastoma (Disease Ontology:DOID:687); rheumatoid arthritis (Disease Ontology:DOID:7148); retinoblastoma (Disease Ontology:DOID:768); cataract (Disease Ontology:DOID:83); chronic myeloid leukemia (Disease Ontology:DOID:8552); infectious mononucleosis (Disease Ontology:DOID:8568); ulcerative colitis (Disease Ontology:DOID:8577); autoimmune thrombocytopenic purpura (Disease Ontology:DOID:8924); systemic lupus erythematosus (Disease Ontology:DOID:9074); acute myeloid leukemia (Disease Ontology:DOID:9119); Barrett's esophagus (Disease Ontology:DOID:9206); ocular hypertension (Disease Ontology:DOID:9282); type 1 diabetes mellitus (Disease Ontology:DOID:9744); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:14102); (R-MMU-3371378); (R-MMU-5218900); (R-MMU-69416); (R-MMU-75157)", "pathway_count": 5, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;11034606;1371136;1372394;15383280;17242355;17545588;19144319;21183079;21750661;23785138;25428506;30016717;7680478;9215629", "class_list": "", "function": "Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase CASP8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs CASP8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 84, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q6GT31;Q9DCQ1", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0005516 calmodulin binding;GO:0042802 identical protein binding;GO:0019900 kinase binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0042127 regulation of cell population proliferation;GO:0043065 positive regulation of apoptotic process;GO:0043066 negative regulation of apoptotic process;GO:0051402 neuron apoptotic process;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P25446-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "L7N465-1", "uniprot_id": [ { "id": "L7N465_MOUSE", "url": "https://www.uniprot.org/uniprot/L7N465", "type": "external" } ], "mass": 26228.0, "length": 225, "protein_name": "Predicted gene 10413; Predicted gene 3012", "gene_name": "Gm3012", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gm3012; Gm10413", "gene_names_refseq": "", "protein_names_uniprotkb": "Predicted gene 10413; Predicted gene 3012", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "L7N465-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1W2P884-1", "uniprot_id": [ { "id": "CE85L_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A1W2P884", "type": "external" } ], "mass": 91831.0, "length": 806, "protein_name": "Centrosomal protein of 85 kDa-like", "gene_name": "Cep85l", "organism": "Mouse", "refseq_name": "centrosomal protein of 85 kDa-like", "refseq_ac": [ { "id": "NP_001191912", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001191912", "type": "external" } ], "gene_names_uniprotkb": "Cep85l; Gm9766", "gene_names_refseq": "1700003O08Rik; Cep85l; Gm9766", "protein_names_uniprotkb": "Centrosomal protein of 85 kDa-like", "protein_names_refseq": "centrosomal protein of 85 kDa-like", "tax_id": 10090, "disease": "lissencephaly 10 (Disease Ontology:DOID:0112229)", "pathway": " (mmu:100038725)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;32097630", "class_list": "", "function": "Plays an essential role in neuronal cell migration., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0000242 pericentriolar material", "go_biological_process": "GO:0001764 neuron migration", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A1W2P884-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VIE6-1", "uniprot_id": [ { "id": "S7A12_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VIE6", "type": "external" } ], "mass": 50947.0, "length": 465, "protein_name": "Solute carrier family 7 member 12", "gene_name": "Slc7a12", "organism": "Mouse", "refseq_name": "solute carrier family 7 member 12", "refseq_ac": [ { "id": "NP_543128", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_543128", "type": "external" } ], "gene_names_uniprotkb": "Slc7a12", "gene_names_refseq": "Asc-2; Slc7a12; XAT-1; XAT1", "protein_names_uniprotkb": "Solute carrier family 7 member 12; Asc-2; Asc-type amino acid transporter 2; X-amino acid transporter 1; XAT-1", "protein_names_refseq": "Asc-2,asc-type amino acid transporter 2; X-amino acid transporter 1; solute carrier family 7 member 12", "tax_id": 10090, "disease": "", "pathway": " (mmu:140918)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11591708;11943479;21750661;31599954", "class_list": "", "function": "Probably mediates sodium- and chloride-independent uptake of neutral amino acids., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R2J1", "ec_number_list": [], "go_molecular_function": "GO:0015179 L-amino acid transmembrane transporter activity;GO:0015171 amino acid transmembrane transporter activity;GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0009925 basal plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006865 amino acid transport;GO:0003333 amino acid transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8VIE6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D011-1", "uniprot_id": [ { "id": "MPLKI_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D011", "type": "external" } ], "mass": 19060.0, "length": 178, "protein_name": "M-phase-specific PLK1-interacting protein", "gene_name": "Mplkip", "organism": "Mouse", "refseq_name": "M-phase-specific PLK1-interacting protein", "refseq_ac": [ { "id": "NP_079755", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079755", "type": "external" } ], "gene_names_uniprotkb": "Mplkip; Ttdn1", "gene_names_refseq": "2810021B07Rik; C330007M08Rik; Mplkip; Ttdn1", "protein_names_uniprotkb": "M-phase-specific PLK1-interacting protein; TTD non-photosensitive 1 protein homolog", "protein_names_refseq": "M-phase-specific PLK1-interacting protein; TTD non-photosensitive 1 protein homolog", "tax_id": 10090, "disease": "nonphotosensitive trichothiodystrophy 4 (Disease Ontology:DOID:0050528)", "pathway": " (mmu:66308)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;24129315", "class_list": "", "function": "May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005813 centrosome", "go_biological_process": "GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D011-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63030-1", "uniprot_id": [ { "id": "MPC1_MOUSE", "url": "https://www.uniprot.org/uniprot/P63030", "type": "external" } ], "mass": 12455.0, "length": 109, "protein_name": "Mitochondrial pyruvate carrier 1", "gene_name": "Mpc1", "organism": "Mouse", "refseq_name": "mitochondrial pyruvate carrier 1 isoform 1", "refseq_ac": [ { "id": "NP_061289", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061289", "type": "external" } ], "gene_names_uniprotkb": "Mpc1; Brp44l", "gene_names_refseq": "0610006G08Rik; 3830411I18Rik; Brp44l; Mpc1", "protein_names_uniprotkb": "Mitochondrial pyruvate carrier 1; Brain protein 44-like protein", "protein_names_refseq": "apoptosis-regulating basic protein; brain protein 44-like protein; mitochondrial pyruvate carrier 1 isoform 1", "tax_id": 10090, "disease": "mitochondrial pyruvate carrier deficiency (Disease Ontology:DOID:0080363); intestinal cancer (Disease Ontology:DOID:10155); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (mmu:55951)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11252172;21750661;22628554;23576753;25458843;34428180;36288343", "class_list": "", "function": "Mediates the uptake of pyruvate into mitochondria to maintain the balance between glycolysis and oxidative phosphorylation (PubMed:22628554). Plays an essential role in cellular metabolism (By similarity)., [UniProtKB, PubMed, UniProtKB]; Mediates the uptake of pyruvate into mitochondria., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Oxidative glutaminolysis supports the TCA cycle in mouse cells lacking MPC1/2., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D6C0;Q9JLG5", "ec_number_list": [], "go_molecular_function": "GO:0050833 pyruvate transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0097228 sperm principal piece", "go_biological_process": "GO:1990830 cellular response to leukemia inhibitory factor;GO:0006086 pyruvate decarboxylation to acetyl-CoA;GO:0006850 pyruvate import into mitochondria", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P63030-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VHK5-1", "uniprot_id": [ { "id": "MLC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VHK5", "type": "external" } ], "mass": 41596.0, "length": 382, "protein_name": "Membrane protein MLC1", "gene_name": "Mlc1", "organism": "Mouse", "refseq_name": "membrane protein MLC1 isoform 1", "refseq_ac": [ { "id": "NP_573504", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_573504", "type": "external" } ], "gene_names_uniprotkb": "Mlc1", "gene_names_refseq": "Kiaa0027-hp; LVM; MLC; Mlc1; VL; WKL1", "protein_names_uniprotkb": "Membrane protein MLC1", "protein_names_refseq": "membrane protein MLC1 isoform 1; membrane protein MLC1", "tax_id": 10090, "disease": "megalencephalic leukoencephalopathy with subcortical cysts 1 (Disease Ontology:DOID:0080316)", "pathway": " (mmu:170790)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12658361;14603469;14755440;15367490;21183079;21750661;34428180;38141856", "class_list": "", "function": "Because the temporal expression of Mlc1 indicates that, in contrast to developing and mature astrocytes, oligodendrocytes are devoid of Mlc1 expression, white matter tract abnormalities in these disorders may result from a primary astrocytic defect., [RefSeq, PubMed]; Localization and functional analysis of Mlc1 were done in megalocephalic leukoencephalopathy with subcortical cysts., [RefSeq, PubMed]; Megalencephalic leukoencephalopathy with subcortical cysts protein-1: A new calcium-sensitive protein functionally activated by endoplasmic reticulum calcium release and calmodulin binding in astrocytes., [RefSeq, PubMed]; The complete cDNA sequence, exon-intron organization, and 5'-flanking regulatory region of murine Mlc1 have been reported., [RefSeq, PubMed]; Transmembrane protein mainly expressed in brain astrocytes that may play a role in transport across the blood-brain and brain-cerebrospinal fluid barriers. Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx. May function as regulatory protein of membrane protein complexes such as ion channels., [UniProtKB, UniProtKB]; Wkl1 is not associated with schizophrenia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0072584 caveolin-mediated endocytosis;GO:0015031 protein transport;GO:0071397 cellular response to cholesterol;GO:0016192 vesicle-mediated transport;GO:0032388 positive regulation of intracellular transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8VHK5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16332-1", "uniprot_id": [ { "id": "MUTA_MOUSE", "url": "https://www.uniprot.org/uniprot/P16332", "type": "external" } ], "mass": 82844.0, "length": 748, "protein_name": "Methylmalonyl-CoA mutase, mitochondrial", "gene_name": "Mmut", "organism": "Mouse", "refseq_name": "methylmalonyl-CoA mutase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_032676", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032676", "type": "external" } ], "gene_names_uniprotkb": "Mmut; Mut", "gene_names_refseq": "D230010K02Rik; Mcm; Mmut; Mut", "protein_names_uniprotkb": "Methylmalonyl-CoA mutase, mitochondrial; 5.4.99.2; MCM; Methylmalonyl-CoA isomerase", "protein_names_refseq": "methylmalonyl-CoA isomerase; methylmalonyl-CoA mutase, mitochondrial precursor; methylmalonyl-CoA mutase, mitochondrial", "tax_id": 10090, "disease": "methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency (Disease Ontology:DOID:0060740); methylmalonic acidemia (Disease Ontology:DOID:14749)", "pathway": " (mmu:17850); (R-MMU-71032); (R-MMU-9759218)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;19372376;1978672;21750661;23576753;23806337;25428506;35820727;36717752;37453647", "class_list": "", "function": "Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle., [UniProtKB, PubMed]; Includes the study of an upstream ORF in this gene, and shows that it functions to reduce protein levels by ~61%., [RefSeq, PubMed]; Integrated multi-omics reveals anaplerotic rewiring in methylmalonyl-CoA mutase deficiency., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UJU1", "ec_number_list": [ { "id": "5.4.99.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.2", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0031419 cobalamin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0043547 positive regulation of GTPase activity;GO:0009791 post-embryonic development;GO:0050667 homocysteine metabolic process;GO:1901290 succinyl-CoA biosynthetic process;GO:0019678 propionate metabolic process, methylmalonyl pathway", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P16332-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20357-1", "uniprot_id": [ { "id": "MTAP2_MOUSE", "url": "https://www.uniprot.org/uniprot/P20357", "type": "external" } ], "mass": 199132.0, "length": 1828, "protein_name": "Microtubule-associated protein 2", "gene_name": "Map2", "organism": "Mouse", "refseq_name": "microtubule-associated protein 2 isoform 3", "refseq_ac": [ { "id": "NP_001297563", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297563", "type": "external" } ], "gene_names_uniprotkb": "Map2; Mtap2", "gene_names_refseq": "G1-397-34; MAP-2; Map2; Mtap-2; Mtap2; repro4", "protein_names_uniprotkb": "Microtubule-associated protein 2; MAP-2", "protein_names_refseq": "microtubule-associated protein 2 isoform 3", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); asphyxia neonatorum (Disease Ontology:DOID:11088); arteriovenous malformation (Disease Ontology:DOID:11294); sciatic neuropathy (Disease Ontology:DOID:11446); Lewy body dementia (Disease Ontology:DOID:12217); Huntington's disease (Disease Ontology:DOID:12858); brain ischemia (Disease Ontology:DOID:2316); temporal lobe epilepsy (Disease Ontology:DOID:3328); cerebral infarction (Disease Ontology:DOID:3526); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:17756)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;10.3389/fragi.2021.757801;15345747;16452087;17114649;17984326;21183079;21385318;21750661;22645316;27074656;30059200;3142041;3205744;32848054;33300544;35822049;37828378;40021952;40885482", "class_list": "", "function": "The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 23, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 23, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 23, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 50, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 10, "glyco_site_count": 27, "binding_glycan_count": 0, "secondary_ac_list": "E9QLE1", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005516 calmodulin binding;GO:0008017 microtubule binding;GO:0019901 protein kinase binding;GO:0002162 dystroglycan binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule;GO:0005886 plasma membrane", "go_biological_process": "GO:0007409 axonogenesis;GO:0016358 dendrite development;GO:0031175 neuron projection development;GO:0032880 regulation of protein localization;GO:0007026 negative regulation of microtubule depolymerization", "synthesized_glycan_count": 0, "hit_score": 4.9, "record_id": "P20357-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31938-1", "uniprot_id": [ { "id": "MP2K1_MOUSE", "url": "https://www.uniprot.org/uniprot/P31938", "type": "external" } ], "mass": 43474.0, "length": 393, "protein_name": "Dual specificity mitogen-activated protein kinase kinase 1", "gene_name": "Map2k1", "organism": "Mouse", "refseq_name": "dual specificity mitogen-activated protein kinase kinase 1 isoform 1", "refseq_ac": [ { "id": "NP_032953", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032953", "type": "external" } ], "gene_names_uniprotkb": "Map2k1; Mek1; Prkmk1", "gene_names_refseq": "MAPKK1; MEKK1; Map2k1; Mek1; Prkmk1", "protein_names_uniprotkb": "Dual specificity mitogen-activated protein kinase kinase 1; 2.7.12.2; ERK activator kinase 1; MAP kinase kinase 1; MAPK/ERK kinase 1; MAPKK 1; MEK 1", "protein_names_refseq": "ERK activator kinase 1; MAP kinase kinase 1; MAPK/ERK kinase 1; dual specificity mitogen-activated protein kinase kinase 1 isoform 1; dual specificity mitogen-activated protein kinase kinase 1; protein kinase, mitogen activated, kinase 1, p45", "tax_id": 10090, "disease": "cardiofaciocutaneous syndrome (Disease Ontology:DOID:0060233); RASopathy (Disease Ontology:DOID:0080690); cardiofaciocutaneous syndrome 3 (Disease Ontology:DOID:0111462); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); prostate adenocarcinoma (Disease Ontology:DOID:2526); high grade glioma (Disease Ontology:DOID:3070); lung adenocarcinoma (Disease Ontology:DOID:3910); ovarian carcinoma (Disease Ontology:DOID:4001); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); melorheostosis (Disease Ontology:DOID:4253); renal cell carcinoma (Disease Ontology:DOID:4450); small intestine adenocarcinoma (Disease Ontology:DOID:4906); cataract (Disease Ontology:DOID:83)", "pathway": " (mmu:26395); (R-MMU-110056); (R-MMU-170968); (R-MMU-445144); (R-MMU-5673000); (R-MMU-5674135); (R-MMU-5674499)", "pathway_count": 7, "publication_count": 34, "publication_id_list": "10.1101/2023.09.13.557529;10409742;10749122;1381507;1411546;15118098;15520807;19219045;19565474;19607848;21183079;21779493;23319590;25153642;25428506;25971971;28135057;28225038;28528544;30084848;30862120;31219806;33300544;34428180;36210013;37507081;38826084;7648369;7731726;8131746;8385802;8940180;9563949;9779990", "class_list": "", "function": "Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (By similarity). Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis., [UniProtKB, UniProtKB, PubMed]; Hyperactivation of MEK1 in cortical glutamatergic neurons results in projection axon deficits and aberrant motor learning., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 14, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:2000641 regulation of early endosome to late endosome transport;GO:0030878 thyroid gland development;GO:0046579 positive regulation of Ras protein signal transduction;GO:0045933 positive regulation of muscle contraction;GO:2001171 positive regulation of ATP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 3.9, "record_id": "P31938-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3KNA1-1", "uniprot_id": [ { "id": "MRGB2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3KNA1", "type": "external" } ], "mass": 38832.0, "length": 338, "protein_name": "Mas-related G protein-coupled receptor member B2", "gene_name": "Mrgprb2", "organism": "Mouse", "refseq_name": "mas-related G-protein coupled receptor member B2", "refseq_ac": [ { "id": "NP_780740", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780740", "type": "external" } ], "gene_names_uniprotkb": "Mrgprb2; Mrgb2", "gene_names_refseq": "4833406I20Rik; Mgrg14; Mrgprb2", "protein_names_uniprotkb": "Mas-related G protein-coupled receptor member B2", "protein_names_refseq": "Mas-related G protein-coupled receptor g14; mas-related G-protein coupled receptor member B2", "tax_id": 10090, "disease": "", "pathway": " (mmu:243979)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11551509;25517090;30686732;38689089", "class_list": "", "function": "Basic secretagogues activate mouse mast cells in vitro and in vivo through a single receptor, Mrgprb2, the orthologue of the human G-protein-coupled receptor MRGPRX2, [RefSeq, PubMed]; Mast cell-specific G protein-coupled receptor for basic secretagogues, which regulates mast cell degranulation and itch-related hypersensitivity reactions (PubMed:25517090). A secretagogue is an agent that promotes the secretion of hormones, neurohormones, chemical neurotransmitters or other compounds synthesized and secreted by cells (PubMed:25517090). Basic secretagogues comprise a set of cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core (PubMed:25517090). Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction (PubMed:25517090). Acts as a receptor for substance P, a basic secretagogue neuropeptide released from the terminals of specific sensory nerves, initiating a signaling that mediates neurogenic inflammation and pain (PubMed:30686732). Neurogenic inflammation includes mast cell activation, recruitment of immune cells and release of inflammatory mediators, such as cytokines and chemokines (PubMed:30686732)., [UniProtKB, PubMed, PubMed]; Mrgprb2-mediated mast cell activation exacerbates Modic changes by regulating immune niches., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8CDY4;Q91ZC2", "ec_number_list": [], "go_molecular_function": "GO:0004985 G protein-coupled opioid receptor activity;GO:0004930 G protein-coupled receptor activity;GO:0016493 C-C chemokine receptor activity;GO:1990595 mast cell secretagogue receptor activity;GO:0042923 neuropeptide binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0016477 cell migration;GO:0032722 positive regulation of chemokine production;GO:0001819 positive regulation of cytokine production", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3KNA1-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UU96-1", "uniprot_id": [ { "id": "MRCKA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UU96", "type": "external" } ], "mass": 195536.0, "length": 1719, "protein_name": "Serine/threonine-protein kinase MRCK alpha", "gene_name": "Cdc42bpa", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase MRCK alpha isoform 2", "refseq_ac": [ { "id": "NP_001333733", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333733", "type": "external" } ], "gene_names_uniprotkb": "Cdc42bpa; Kiaa0451", "gene_names_refseq": "A930014J19Rik; Cdc42bpa; DMPK-like", "protein_names_uniprotkb": "Serine/threonine-protein kinase MRCK alpha; 2.7.11.1; CDC42-binding protein kinase alpha", "protein_names_refseq": "myotonic dystrophy kinase-related CDC-42-binding kinase-alpha; serine/threonine-protein kinase MRCK alpha isoform 2; serine/threonine-protein kinase MRCK alpha", "tax_id": 10090, "disease": "cerebral cavernous malformation (Disease Ontology:DOID:0060669); azoospermia (Disease Ontology:DOID:14227)", "pathway": " (mmu:226751); (R-MMU-9013149); (R-MMU-9013406)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;21750661;22645316;25107909;30084848;31219806;33476437;34428180;37651121;40885482", "class_list": "", "function": "MRCK activates mouse oocyte myosin II for spindle rotation and male pronucleus centration., [RefSeq, PubMed]; Myotonic dystrophy kinase-related CDC42-binding kinase alpha, a new transferrin receptor type 2-binding partner, is a regulator of erythropoiesis., [RefSeq, PubMed]; Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LRP35A, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A and LIMK2. May play a role in TFRC-mediated iron uptake (By similarity). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (PubMed:25107909). Triggers the formation of an extrusion apical actin ring required for epithelial extrusion of apoptotic cells (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B2RY49;Q4V9U7;Q6ZQA9;Q8R495", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "1.6.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "1.16.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.1.-", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005911 cell-cell junction;GO:0030027 lamellipodium;GO:0031252 cell leading edge", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0016477 cell migration;GO:0051056 regulation of small GTPase mediated signal transduction;GO:0030036 actin cytoskeleton organization;GO:0007010 cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q3UU96-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0H2-1", "uniprot_id": [ { "id": "MUCEN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R0H2", "type": "external" } ], "mass": 27756.0, "length": 261, "protein_name": "Endomucin", "gene_name": "Emcn", "organism": "Mouse", "refseq_name": "endomucin isoform 1 precursor", "refseq_ac": [ { "id": "NP_001156994", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156994", "type": "external" } ], "gene_names_uniprotkb": "Emcn; Muc14", "gene_names_refseq": "0610012K22Rik; Emcn; Muc14", "protein_names_uniprotkb": "Endomucin; Endomucin-1/2; MUC-14; Mucin-14", "protein_names_refseq": "MUC-14; endomucin isoform 1 precursor; endomucin-1/2; endomucin-1; mucin 14, endothelial; mucin-14", "tax_id": 10090, "disease": "thyroid gland carcinoma (Disease Ontology:DOID:3963)", "pathway": " (mmu:59308)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11418125;11554756;21183079;21750661;9864158", "class_list": "", "function": "Endothelial sialomucin, also called endomucin or mucin-like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q78KL2;Q9DCN9;Q9ULC1;Q9Z2I1", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0030155 regulation of cell adhesion;GO:0098609 cell-cell adhesion;GO:0061484 hematopoietic stem cell homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9R0H2-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WV34-1", "uniprot_id": [ { "id": "MPP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WV34", "type": "external" } ], "mass": 61555.0, "length": 552, "protein_name": "MAGUK p55 subfamily member 2", "gene_name": "Mpp2", "organism": "Mouse", "refseq_name": "MAGUK p55 subfamily member 2 isoform 2", "refseq_ac": [ { "id": "NP_057904", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_057904", "type": "external" } ], "gene_names_uniprotkb": "Mpp2; Dlgh2", "gene_names_refseq": "D11Bwg0652e; Dlg2; Dlgh2; Mpp2; Pals4", "protein_names_uniprotkb": "MAGUK p55 subfamily member 2; Discs large homolog 2; Protein MPP2", "protein_names_refseq": "MAGUK p55 subfamily member 2 isoform 2; MAGUK p55 subfamily member 2; discs large homolog 2; p55 subfamily member of MAGUK family", "tax_id": 10090, "disease": "", "pathway": " (mmu:50997)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15345747;21183079;22645316;26880549;32848054;34428180;35854144;37469037", "class_list": "", "function": "Involvement of membrane palmitoylated protein 2 (MPP2) in the synaptic molecular complex at the mouse cerebellar glomerulus., [RefSeq, PubMed]; MPP2 interacts with SK2 to rescue the excitability of glutamatergic neurons in the BLA and facilitate the extinction of conditioned fear in mice., [RefSeq, PubMed]; Postsynaptic MAGUK scaffold protein that links CADM1 cell adhesion molecules to core components of the postsynaptic density (By similarity). In CA1 pyramidal neurons, required for synaptic KCNN2-containing channel function and long-term potentiation expression (PubMed:26880549). Seems to negatively regulate SRC function in epithelial cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Thus, MPP2 is a novel synaptic scaffold that is required for proper synaptic localization and function of SK2-containing channels. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B1AQF8;Q3T9W1;Q3TT52;Q3URK8", "ec_number_list": [], "go_molecular_function": "GO:0044325 transmembrane transporter binding;GO:0030165 PDZ domain binding;GO:0098919 structural constituent of postsynaptic density", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0014069 postsynaptic density", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0060079 excitatory postsynaptic potential;GO:0060291 long-term synaptic potentiation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9WV34-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70145-1", "uniprot_id": [ { "id": "NCF2_MOUSE", "url": "https://www.uniprot.org/uniprot/O70145", "type": "external" } ], "mass": 59485.0, "length": 525, "protein_name": "Neutrophil cytosol factor 2", "gene_name": "Ncf2", "organism": "Mouse", "refseq_name": "neutrophil cytosol factor 2 isoform 1", "refseq_ac": [ { "id": "NP_035007", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035007", "type": "external" } ], "gene_names_uniprotkb": "Ncf2; Noxa2; P67phox", "gene_names_refseq": "NOXA2; Ncf-2; Ncf2; p67phox", "protein_names_uniprotkb": "Neutrophil cytosol factor 2; 67 kDa neutrophil oxidase factor; NADPH oxidase activator 2; NCF-2; Neutrophil NADPH oxidase factor 2; p67-phox", "protein_names_refseq": "67 kDa neutrophil oxidase factor; NADPH oxidase activator 2; NADPH oxidase subunit (67kDa); neutrophil NADPH oxidase factor 2; neutrophil cytosol factor 2 isoform 1; neutrophil cytosol factor 2", "tax_id": 10090, "disease": "renal fibrosis (Disease Ontology:DOID:0050855); autosomal recessive chronic granulomatous disease 2 (Disease Ontology:DOID:0070191); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); status epilepticus (Disease Ontology:DOID:1824); proteinuria (Disease Ontology:DOID:576); rheumatoid arthritis (Disease Ontology:DOID:7148); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:17970); (R-MMU-1222556); (R-MMU-1236973); (R-MMU-3299685); (R-MMU-4420097); (R-MMU-5668599); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013423)", "pathway_count": 9, "publication_count": 11, "publication_id_list": "19144319;21183079;21551061;21750661;26740625;28315936;30084848;30779550;34428180;35820727;9490028", "class_list": "", "function": "NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production)., [UniProtKB, UniProtKB]; Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction. Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane (By similarity). This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TC92;Q3U5S4", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding;GO:0016176 superoxide-generating NADPH oxidase activator activity", "go_cellular_component": "GO:0043020 NADPH oxidase complex;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0032496 response to lipopolysaccharide;GO:0045777 positive regulation of blood pressure;GO:0006909 phagocytosis;GO:0032870 cellular response to hormone stimulus;GO:0009749 response to glucose", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O70145-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61122-1", "uniprot_id": [ { "id": "NAB1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61122", "type": "external" } ], "mass": 54010.0, "length": 486, "protein_name": "NGFI-A-binding protein 1", "gene_name": "Nab1", "organism": "Mouse", "refseq_name": "NGFI-A-binding protein 1 isoform 1", "refseq_ac": [ { "id": "NP_032693", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032693", "type": "external" } ], "gene_names_uniprotkb": "Nab1", "gene_names_refseq": "Nab1", "protein_names_uniprotkb": "NGFI-A-binding protein 1; EGR-1-binding protein 1", "protein_names_refseq": "EGR-1-binding protein 1; NGFI-A-binding protein 1 isoform 1; NGFI-A-binding protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:17936)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "17242355;21183079;21750661;23935197;40885482;7624335;8668170;9774344", "class_list": "", "function": "Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2., [UniProtKB, PubMed]; These data suggest that type I IFN stimulation induces a rapid recruitment of a repressive Egr3/Nab1 complex that silences transcription from the ifngr1 promoter., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q99J24", "ec_number_list": [], "go_molecular_function": "GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0042552 myelination;GO:0045892 negative regulation of DNA-templated transcription;GO:0014037 Schwann cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q61122-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D1N4-1", "uniprot_id": [ { "id": "MYMK_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D1N4", "type": "external" } ], "mass": 24792.0, "length": 221, "protein_name": "Protein myomaker", "gene_name": "Mymk", "organism": "Mouse", "refseq_name": "protein myomaker isoform 2", "refseq_ac": [ { "id": "NP_001153074", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153074", "type": "external" } ], "gene_names_uniprotkb": "Mymk; Tmem8c", "gene_names_refseq": "1110002H13Rik; Mymk; Tmem8c; myomaker", "protein_names_uniprotkb": "Protein myomaker; Myoblast fusion maker; Transmembrane protein 8C", "protein_names_refseq": "myoblast fusion maker; protein myomaker isoform 2; protein myomaker; transmembrane protein 8C", "tax_id": 10090, "disease": "Carey-Fineman-Ziter syndrome 1 (Disease Ontology:DOID:0061115); Carey-Fineman-Ziter syndrome (Disease Ontology:DOID:0080194)", "pathway": " (mmu:66139)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "21750661;23868259;25085416;26858401;28186492;28386024;28579197;28681861;28860190;30197239", "class_list": "", "function": "Data indicate that the majority of myomaker is embedded in the plasma membrane with seven membrane-spanning regions and a required intracellular C-terminal tail., [RefSeq, PubMed]; Myoblast-specific protein that mediates myoblast fusion, an essential step for the formation of multi-nucleated muscle fibers (PubMed:23868259, PubMed:28386024, PubMed:28681861, PubMed:30197239). Actively participates in the membrane fusion reaction by mediating the mixing of cell membrane lipids (hemifusion) upstream of MYMX (PubMed:30197239). Acts independently of MYMX (PubMed:30197239). Involved in skeletal muscle regeneration in response to injury by mediating the fusion of satellite cells, a population of muscle stem cells, with injured myofibers (PubMed:25085416). Also involved in skeletal muscle hypertrophy, probably by mediating the fusion of satellite cells with myofibers (PubMed:28186492)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Myogenic basic helix-loop-helix (bHLH) transcription factors induce myomaker expression in satellite cells during acute and chronic muscle regeneration., [RefSeq, PubMed]; The findings reveal myomaker (transmembrane protein 8c) as a long-sought myogenic fusion protein that controls mammalian myoblast fusion., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0043403 skeletal muscle tissue regeneration;GO:0007517 muscle organ development;GO:0007520 myoblast fusion;GO:1904206 positive regulation of skeletal muscle hypertrophy;GO:0014905 myoblast fusion involved in skeletal muscle regeneration", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9D1N4-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VDD5-1", "uniprot_id": [ { "id": "MYH9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VDD5", "type": "external" } ], "mass": 226372.0, "length": 1960, "protein_name": "Myosin-9", "gene_name": "Myh9", "organism": "Mouse", "refseq_name": "myosin-9", "refseq_ac": [ { "id": "NP_071855", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071855", "type": "external" } ], "gene_names_uniprotkb": "Myh9", "gene_names_refseq": "Fltn; Myh9; Myhn-1; Myhn1; NMHC II-A; NMHCIIA; NMMHC-A; NMMHC-IIA; TU72.6", "protein_names_uniprotkb": "Myosin-9; Cellular myosin heavy chain, type A; Myosin heavy chain 9; Myosin heavy chain, non-muscle IIa; NMMHC II-a; NMMHC-A; NMMHC-IIA; Non-muscle myosin heavy chain A; Non-muscle myosin heavy chain IIa", "protein_names_refseq": "cellular myosin heavy chain, type A; flectin; myosin IIA; myosin heavy chain IX; myosin-9; non-muscle myosin heavy chain IIa", "tax_id": 10090, "disease": "orofacial cleft (Disease Ontology:DOID:0050567); metabolic acidosis (Disease Ontology:DOID:0050758); MYH-9 related disease (Disease Ontology:DOID:0060651); Alport syndrome 3A (Disease Ontology:DOID:0110032); autosomal dominant nonsyndromic deafness 17 (Disease Ontology:DOID:0110548); sensorineural hearing loss (Disease Ontology:DOID:10003); thrombocytopenia (Disease Ontology:DOID:1588); kidney disease (Disease Ontology:DOID:557); proteinuria (Disease Ontology:DOID:576); end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (mmu:17886); (R-MMU-2029482); (R-MMU-5627123)", "pathway_count": 3, "publication_count": 52, "publication_id_list": "10.1101/2023.09.13.557529;11943476;16139798;16452087;17208939;17242355;17947660;18299400;18630941;19131326;19144319;19401332;20173027;20484733;21183079;21396893;21540332;21750661;21952136;22645316;23806337;24788674;25428506;25428507;25605945;26495903;26740625;27331610;27802388;28011936;29187734;30084848;30389720;30779550;30899004;31118423;31219806;31599954;32152506;32685004;34428180;34716313;34887587;35820727;36064721;36210013;36288343;37453647;37507081;37828378;39627609;39927985", "class_list": "", "function": "Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping (PubMed:19401332). Required for cortical actin clearance prior to oocyte exocytosis (PubMed:31118423). Promotes cell motility in conjunction with S100A4 (By similarity). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 10, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UHT9;Q3UHU4;Q6KAN6;Q811I2", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005178 integrin binding;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005819 spindle", "go_biological_process": "GO:0001778 plasma membrane repair;GO:1903923 positive regulation of protein processing in phagocytic vesicle;GO:0060327 cytoplasmic actin-based contraction involved in cell motility;GO:0032962 positive regulation of inositol trisphosphate biosynthetic process;GO:0001525 angiogenesis", "synthesized_glycan_count": 0, "hit_score": 6.0, "record_id": "Q8VDD5-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08638-1", "uniprot_id": [ { "id": "MYH11_MOUSE", "url": "https://www.uniprot.org/uniprot/O08638", "type": "external" } ], "mass": 227028.0, "length": 1972, "protein_name": "Myosin-11", "gene_name": "Myh11", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Myh11", "gene_names_refseq": "", "protein_names_uniprotkb": "Myosin-11; Myosin heavy chain 11; Myosin heavy chain, smooth muscle isoform; SMMHC", "protein_names_refseq": "", "tax_id": 10090, "disease": "megacystis-microcolon-intestinal hypoperistalsis syndrome (Disease Ontology:DOID:0060610); MYH-9 related disease (Disease Ontology:DOID:0060651); patent ductus arteriosus (Disease Ontology:DOID:13832); thoracic aortic aneurysm (Disease Ontology:DOID:14004); abdominal aortic aneurysm (Disease Ontology:DOID:7693)", "pathway": " (mmu:17880); (R-MMU-445355); (R-MMU-5627123)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;17242355;21183079;21750661;34428180;34887587;36064721;36288343;37453647;37507081;7923625;8593698;9125171", "class_list": "", "function": "Muscle contraction., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O08639;Q62462;Q64195", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0008307 structural constituent of muscle;GO:0003774 cytoskeletal motor activity", "go_cellular_component": "GO:0005859 muscle myosin complex;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005903 brush border", "go_biological_process": "GO:0006939 smooth muscle contraction;GO:0031032 actomyosin structure organization;GO:0055013 cardiac muscle cell development;GO:0048251 elastic fiber assembly;GO:0030241 skeletal muscle myosin thick filament assembly", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "O08638-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70624-1", "uniprot_id": [ { "id": "MYOC_MOUSE", "url": "https://www.uniprot.org/uniprot/O70624", "type": "external" } ], "mass": 55314.0, "length": 490, "protein_name": "Myocilin", "gene_name": "Myoc", "organism": "Mouse", "refseq_name": "myocilin precursor", "refseq_ac": [ { "id": "NP_034995", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034995", "type": "external" } ], "gene_names_uniprotkb": "Myoc; Tigr", "gene_names_refseq": "GLC1A; Myoc; TIGR", "protein_names_uniprotkb": "Myocilin; Myocilin 20 kDa N-terminal fragment; Myocilin 35 kDa N-terminal fragment; Trabecular meshwork-induced glucocorticoid response protein", "protein_names_refseq": "myocilin precursor; trabecular meshwork-induced glucocorticoid response protein", "tax_id": 10090, "disease": "open-angle glaucoma (Disease Ontology:DOID:1067); juvenile glaucoma (Disease Ontology:DOID:1068); primary open angle glaucoma (Disease Ontology:DOID:1070); low tension glaucoma (Disease Ontology:DOID:13544); membranoproliferative glomerulonephritis (Disease Ontology:DOID:2920); ocular hypertension (Disease Ontology:DOID:9282)", "pathway": " (mmu:17926)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "12019210;16392033;19188438;22371502;23629661;23897819;32132110;38453040;9548973;9588210;9675094;9680392", "class_list": "", "function": "Intraocular pressure across the lifespan of Tg-MYOC[Y437H] mice., [RefSeq, PubMed]; MEF2c-Dependent Downregulation of Myocilin Mediates Cancer-Induced Muscle Wasting and Associates with Cachexia in Patients with Cancer., [RefSeq, PubMed]; Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. Promotes cell migration through activation of PTK2 and the downstream phosphatidylinositol 3-kinase signaling (By similarity). Plays a role in bone formation and promotes osteoblast differentiation in a dose-dependent manner through mitogen-activated protein kinase signaling (PubMed:23629661). Mediates myelination in the peripheral nervous system through ERBB2/ERBB3 signaling (PubMed:23897819). Plays a role as a regulator of muscle hypertrophy through the components of dystrophin-associated protein complex (PubMed:22371502). Involved in positive regulation of mitochondrial depolarization. Plays a role in neurite outgrowth. May participate in the obstruction of fluid outflow in the trabecular meshwork (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O70289", "ec_number_list": [], "go_molecular_function": "GO:0005109 frizzled binding;GO:0046872 metal ion binding;GO:0030971 receptor tyrosine kinase binding;GO:0001968 fibronectin binding;GO:0032027 myosin light chain binding", "go_cellular_component": "GO:0035748 myelin sheath abaxonal region;GO:0005615 extracellular space;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0007165 signal transduction;GO:0030335 positive regulation of cell migration;GO:0031175 neuron projection development;GO:0046330 positive regulation of JNK cascade;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O70624-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97500-1", "uniprot_id": [ { "id": "MYT1L_MOUSE", "url": "https://www.uniprot.org/uniprot/P97500", "type": "external" } ], "mass": 132945.0, "length": 1187, "protein_name": "Myelin transcription factor 1-like protein", "gene_name": "Myt1l", "organism": "Mouse", "refseq_name": "myelin transcription factor 1-like protein isoform 1", "refseq_ac": [ { "id": "NP_001087244", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001087244", "type": "external" } ], "gene_names_uniprotkb": "Myt1l; Kiaa1106; Nzf1; Png1", "gene_names_refseq": "2900046C06Rik; 2900093J19Rik; C630034G21Rik; Myt1l; Myt2; Nztf1; Pmng1; Png-1; mKIAA1106", "protein_names_uniprotkb": "Myelin transcription factor 1-like protein; MyT1-L; MyT1L; NZF-1; Neural zinc finger factor 1; Postmitotic neural gene 1 protein; Zinc finger protein Png-1", "protein_names_refseq": "myT1-L; myelin transcription factor 1-like protein isoform 1; myelin transcription factor 1-like protein; neural zinc finger factor 1; neural zinc finger protein NZF-1; neural zinc finger transcription factor 1; postmeiotic neural gene 1; postmitotic neural gene 1 protein; zinc finger protein Png-1", "tax_id": 10090, "disease": "autosomal dominant intellectual developmental disorder 39 (Disease Ontology:DOID:0070069)", "pathway": " (mmu:17933)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;20107439;21183079;21540077;21750661;24243019;27281220;28379941;30059200;9130664;9373037", "class_list": "", "function": "Transcription factor that plays a key role in neuronal differentiation by specifically repressing expression of non-neuronal genes during neuron differentiation (PubMed:28379941). In contrast to other transcription repressors that inhibit specific lineages, mediates repression of multiple differentiation programs (PubMed:28379941). Also represses expression of negative regulators of neurogenesis, such as members of the Notch signaling pathway, including HES1 (PubMed:28379941). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro (PubMed:20107439, PubMed:24243019, PubMed:27281220). Directly binds the 5'-AAGTT-3' core motif present on the promoter of target genes and represses transcription by recruiting a multiprotein complex containing SIN3B (PubMed:28379941). The 5'-AAGTT-3' core motif is absent from the promoter of neural genes (PubMed:28379941)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "A2RRK5;D3Z1P7;O08996;Q33DP0;Q8C643;Q8C7L4;Q8CHB4", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005694 chromosome", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P97500-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02566-1", "uniprot_id": [ { "id": "MYH6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q02566", "type": "external" } ], "mass": 223565.0, "length": 1938, "protein_name": "Myosin-6", "gene_name": "Myh6", "organism": "Mouse", "refseq_name": "myosin-6", "refseq_ac": [ { "id": "NP_001157643", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157643", "type": "external" } ], "gene_names_uniprotkb": "Myh6; Myhca", "gene_names_refseq": "A830009F23Rik; Myh6; Myhc-a; Myhca; alpha-MHC; alphaMHC", "protein_names_uniprotkb": "Myosin-6; MyHC-alpha; Myosin heavy chain 6; Myosin heavy chain, cardiac muscle alpha isoform", "protein_names_refseq": "alpha cardiac MHC; alpha myosin; cardiomyopathy, hypertrophic 1; myHC-alpha; myosin heavy chain 6; myosin heavy chain, cardiac muscle, adult; myosin-6", "tax_id": 10090, "disease": "distal arthrogryposis (Disease Ontology:DOID:0050646); cardiomyopathy (Disease Ontology:DOID:0050700); familial hypertrophic cardiomyopathy (Disease Ontology:DOID:0080326); congenital myopathy 6 (Disease Ontology:DOID:0080719); spondylocarpotarsal synostosis syndrome (Disease Ontology:DOID:0090116); atrial heart septal defect 3 (Disease Ontology:DOID:0110108); hypertrophic cardiomyopathy 1 (Disease Ontology:DOID:0110307); hypertrophic cardiomyopathy 14 (Disease Ontology:DOID:0110320); dilated cardiomyopathy 1EE (Disease Ontology:DOID:0110453); dilated cardiomyopathy 1S (Disease Ontology:DOID:0110454); autosomal dominant hyaline body myopathy (Disease Ontology:DOID:0111269); distal arthrogryposis type 1 (Disease Ontology:DOID:0111596); distal arthrogryposis type 2B3 (Disease Ontology:DOID:0111602); distal arthrogryposis type 2A (Disease Ontology:DOID:0111605); distal myopathy (Disease Ontology:DOID:11720); dilated cardiomyopathy (Disease Ontology:DOID:12930); sick sinus syndrome (Disease Ontology:DOID:13884); hypothyroidism (Disease Ontology:DOID:1459); atrial heart septal defect (Disease Ontology:DOID:1882); myotonia congenita (Disease Ontology:DOID:2106); inclusion body myositis (Disease Ontology:DOID:3429); Wolff-Parkinson-White syndrome (Disease Ontology:DOID:384); restrictive cardiomyopathy (Disease Ontology:DOID:397); myopathy (Disease Ontology:DOID:423); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (mmu:17888); (R-MMU-390522)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "1577481;2026617;21183079;21750661;25428506;31408441;33725478;36288343;36385524;37507081;37830560", "class_list": "", "function": "Muscle contraction., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 26, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q64258;Q64738", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005859 muscle myosin complex;GO:0005737 cytoplasm;GO:0001725 stress fiber;GO:0032982 myosin filament;GO:0030018 Z disc", "go_biological_process": "GO:0060420 regulation of heart growth;GO:0001701 in utero embryonic development;GO:0006936 muscle contraction;GO:0008217 regulation of blood pressure;GO:0008016 regulation of heart contraction", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q02566-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61006-1", "uniprot_id": [ { "id": "MUSK_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61006", "type": "external" } ], "mass": 96693.0, "length": 868, "protein_name": "Muscle, skeletal receptor tyrosine-protein kinase", "gene_name": "Musk", "organism": "Mouse", "refseq_name": "muscle, skeletal receptor tyrosine-protein kinase isoform 2", "refseq_ac": [ { "id": "NP_001032205", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032205", "type": "external" } ], "gene_names_uniprotkb": "Musk; Nsk2", "gene_names_refseq": "Mdk4; Mlk; Musk; Nsk1; Nsk2; Nsk3", "protein_names_uniprotkb": "Muscle, skeletal receptor tyrosine-protein kinase; 2.7.10.1; MuSK; Muscle-specific kinase receptor; Muscle-specific tyrosine-protein kinase receptor", "protein_names_refseq": "muscle localized kinase 2; muscle, skeletal receptor tyrosine-protein kinase isoform 2; muscle, skeletal receptor tyrosine-protein kinase; muscle-specific kinase receptor; muscle-specific tyrosine-protein kinase receptor", "tax_id": 10090, "disease": "congenital myasthenic syndrome 9 (Disease Ontology:DOID:0110670); fetal akinesia deformation sequence syndrome 1 (Disease Ontology:DOID:0111377); myasthenia gravis (Disease Ontology:DOID:437)", "pathway": " (mmu:18198)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "11323662;12165471;12756238;14622576;14678832;15340048;16794080;16818610;17576800;18272689;18848351;19038220;19940021;20603078;34428180;36525997;7624144;8653786;8653787", "class_list": "", "function": "Proteolytic ectodomain shedding of muscle-specific tyrosine kinase in myasthenia gravis., [RefSeq, PubMed]; Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role in acetylcholinesterase (AChE) localization at the neuromuscular junctions (NMJ) via its interaction wit COLQ (By similarity). May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; This gene encodes a member of the protein tyrosine kinase family. The encoded protein is a type 1 receptor-like protein located in muscle membrane that is activated by the heparan sulfate proteoglycan agrin released by nerve cells. The encoded protein activates signaling cascades responsible for multiple aspects of motor neuron and muscle development, including organization of the postsynaptic membrane, synaptic gene transcription, patterning of skeletal muscle, anchoring of acetylcholinesterase, and guidance of motor axons. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q61005;Q61987;Q61988", "ec_number_list": [ { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" } ], "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0046872 metal ion binding;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0031594 neuromuscular junction;GO:0043235 receptor complex;GO:0045202 synapse", "go_biological_process": "GO:0032224 positive regulation of synaptic transmission, cholinergic;GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering;GO:0001934 positive regulation of protein phosphorylation;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007528 neuromuscular junction development", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q61006-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61127-1", "uniprot_id": [ { "id": "NAB2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61127", "type": "external" } ], "mass": 56577.0, "length": 525, "protein_name": "NGFI-A-binding protein 2", "gene_name": "Nab2", "organism": "Mouse", "refseq_name": "NGFI-A-binding protein 2 isoform 2", "refseq_ac": [ { "id": "NP_001116367", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116367", "type": "external" } ], "gene_names_uniprotkb": "Nab2", "gene_names_refseq": "Nab2", "protein_names_uniprotkb": "NGFI-A-binding protein 2; EGR-1-binding protein 2", "protein_names_refseq": "EGR-1-binding protein 2; NGFI-A binding protein 2 (EGR-1 binding protein 2); NGFI-A-binding protein 2 isoform 2; NGFI-A-binding protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:17937); (R-MMU-9031628)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "16136673;19131326;21183079;21750661;28282643;30411343;31219806;34428180;35218524;36210013;8668170;9126479", "class_list": "", "function": "Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability., [UniProtKB]; Loss of Neuron Navigator 2 Impairs Brain and Cerebellar Development., [RefSeq, PubMed]; Nab1 and Nab2 proteins are necessary for Schwann cells to exit the cell cycle, downregulate suppressed cAMP-inducible protein (SCIP) expression and upregulate expression of critical myelination genes., [RefSeq, PubMed]; Study characterized sequences in NAB2 that mediate its nuclear localization and determined that the KKXK motif that aligns with the NAB1 KRXK motif is necessary for NAB2 nuclear localization, while the K(X2)R motif situated 11 residues upstream is not., [RefSeq, PubMed]; These findings indicate a requirement for Nab2 in maintaining thymocyte number in male mice with age and in response to stress., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q80VR9", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0042552 myelination;GO:0014037 Schwann cell differentiation;GO:0001958 endochondral ossification", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q61127-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61879-1", "uniprot_id": [ { "id": "MYH10_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61879", "type": "external" } ], "mass": 228996.0, "length": 1976, "protein_name": "Myosin-10", "gene_name": "Myh10", "organism": "Mouse", "refseq_name": "myosin-10", "refseq_ac": [ { "id": "NP_780469", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780469", "type": "external" } ], "gene_names_uniprotkb": "Myh10", "gene_names_refseq": "5730504C04Rik; 9330167F11Rik; Fltn; Myh10; Myhn-2; Myhn2; NM2B; NMHC II-B; NMHC-B; NMHCII-B; NMMHC II-b; NMMHC-B; NMMHC-IIB; SMemb; mKIAA3005", "protein_names_uniprotkb": "Myosin-10; Cellular myosin heavy chain, type B; Myosin heavy chain 10; Myosin heavy chain, non-muscle IIb; NMMHC II-b; NMMHC-B; NMMHC-IIB; Non-muscle myosin heavy chain B; Non-muscle myosin heavy chain IIb", "protein_names_refseq": "cellular myosin heavy chain, type B; flectin; myosin IIB; myosin heavy chain 10, non-muscle; myosin heavy chain, non-muscle IIb; myosin heavy chain, nonmuscular, type B; myosin-10; non-muscle myosin heavy chain B; non-muscle myosin heavy chain IIb; nonmuscle myosin heavy chain II-B", "tax_id": 10090, "disease": "MYH-9 related disease (Disease Ontology:DOID:0060651)", "pathway": " (mmu:77579); (R-MMU-5627123)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;16452087;16479539;17242355;17892306;19131326;20439720;21183079;21750661;22872234;23806337;24129315;30084848;33300544;34428180;34887587;36064721;36210013;39627609;8931991", "class_list": "", "function": "Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9 (By similarity). Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5SV63", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0051015 actin filament binding;GO:0043531 ADP binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098871 postsynaptic actin cytoskeleton;GO:0005737 cytoplasm;GO:0005819 spindle;GO:0005829 cytosol", "go_biological_process": "GO:0001778 plasma membrane repair;GO:0021592 fourth ventricle development;GO:0001701 in utero embryonic development;GO:0007155 cell adhesion;GO:0007409 axonogenesis", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q61879-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62234-1", "uniprot_id": [ { "id": "MYOM1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62234", "type": "external" } ], "mass": 185464.0, "length": 1667, "protein_name": "Myomesin-1", "gene_name": "Myom1", "organism": "Mouse", "refseq_name": "myomesin-1 isoform 2", "refseq_ac": [ { "id": "NP_001077403", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077403", "type": "external" } ], "gene_names_uniprotkb": "Myom1", "gene_names_refseq": "D430047A17Rik; Myom1", "protein_names_uniprotkb": "Myomesin-1; Myomesin family member 1; Skelemin", "protein_names_refseq": "myomesin family member 1; myomesin-1 isoform 2; skelemin", "tax_id": 10090, "disease": "", "pathway": " (mmu:17929)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10036188;18177667;21183079;21750661;22562206;30084848;34428180;37507081;39927985;8408035;9857037", "class_list": "", "function": "May link the intermediate filament cytoskeleton to the M-disk of the myofibrils in striated muscle. May also contact myosin filaments. Also binds beta-integrins., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q546T8;Q6PAC0", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0019900 kinase binding;GO:0008307 structural constituent of muscle", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0030017 sarcomere;GO:0032982 myosin filament;GO:0031430 M band", "go_biological_process": "GO:0006936 muscle contraction;GO:0010628 positive regulation of gene expression;GO:0050714 positive regulation of protein secretion;GO:0045214 sarcomere organization;GO:0002074 extraocular skeletal muscle development", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q62234-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PDN3-1", "uniprot_id": [ { "id": "MYLK_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PDN3", "type": "external" } ], "mass": 212925.0, "length": 1941, "protein_name": "Myosin light chain kinase, smooth muscle", "gene_name": "Mylk", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mylk", "gene_names_refseq": "", "protein_names_uniprotkb": "Myosin light chain kinase, smooth muscle; 2.7.11.18; KRP; Kinase-related protein; MLCK; Telokin; smMLCK", "protein_names_refseq": "", "tax_id": 10090, "disease": "megacystis-microcolon-intestinal hypoperistalsis syndrome (Disease Ontology:DOID:0060610); adult respiratory distress syndrome (Disease Ontology:DOID:11394); thoracic aortic aneurysm (Disease Ontology:DOID:14004); asthma (Disease Ontology:DOID:2841); coronary artery disease (Disease Ontology:DOID:3393)", "pathway": " (R-MMU-445355); (R-MMU-5627123)", "pathway_count": 2, "publication_count": 23, "publication_id_list": "10.1101/2023.09.13.557529;11029314;11121372;11472067;11832329;12360480;16055522;16184195;16393994;17242355;17577141;17925381;18586037;18587400;20018858;20404178;21074048;21183079;21750661;26495903;34428180;35820727;8764148", "class_list": "", "function": "Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for physiological and asthmatic airway resistance. Necessary for gastrointestinal motility. Implicated in the regulation of endothelial as well as vascular permeability, probably via the regulation of cytoskeletal rearrangements. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences that result in fibroblast apoptosis. Plays a role in the regulation of epithelial cell survival. Required for epithelial wound healing, especially during actomyosin ring contraction during purse-string wound closure. Mediates RhoA-dependent membrane blebbing. Triggers TRPC5 channel activity in a calcium-dependent signaling, by inducing its subcellular localization at the plasma membrane. Promotes cell migration (including tumor cells) and tumor metastasis. PTK2B/PYK2 activation by phosphorylation mediates ITGB2 activation and is thus essential to trigger neutrophil transmigration during acute lung injury (ALI). May regulate optic nerve head astrocyte migration. Probably involved in mitotic cytoskeletal regulation. Regulates tight junction probably by modulating ZO-1 exchange in the perijunctional actomyosin ring. Mediates burn-induced microvascular barrier injury; triggers endothelial contraction in the development of microvascular hyperpermeability by phosphorylating MLC. Essential for intestinal barrier dysfunction. Mediates Giardia spp.-mediated reduced epithelial barrier function during giardiasis intestinal infection via reorganization of cytoskeletal F-actin and tight junctional ZO-1. Necessary for hypotonicity-induced Ca(2+) entry and subsequent activation of volume-sensitive organic osmolyte/anion channels (VSOAC) in cervical cancer cells., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9820, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TSJ7;Q80UX0;Q80YN7;Q80YN8;Q8K026;Q924D2;Q9ERD3", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.18", "type": "external" } ], "go_molecular_function": "GO:0003779 actin binding;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0015629 actin cytoskeleton;GO:0030027 lamellipodium", "go_biological_process": "GO:0071476 cellular hypotonic response;GO:0098969 neurotransmitter receptor transport to postsynaptic membrane;GO:0006939 smooth muscle contraction;GO:0030335 positive regulation of cell migration;GO:0071466 cellular response to xenobiotic stimulus", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q6PDN3-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BG95-1", "uniprot_id": [ { "id": "MYPT2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BG95", "type": "external" } ], "mass": 109049.0, "length": 976, "protein_name": "Protein phosphatase 1 regulatory subunit 12B", "gene_name": "Ppp1r12b", "organism": "Mouse", "refseq_name": "protein phosphatase 1 regulatory subunit 12B isoform 2", "refseq_ac": [ { "id": "NP_001355756", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001355756", "type": "external" } ], "gene_names_uniprotkb": "Ppp1r12b; Mypt2", "gene_names_refseq": "1810037O03Rik; 9530009M10Rik; Mypt2; Ppp1r12b", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 12B; Myosin phosphatase target subunit 2; Myosin phosphatase-targeting subunit 2", "protein_names_refseq": "myosin phosphatase target subunit 2; myosin phosphatase-targeting subunit 2; protein phosphatase 1 regulatory subunit 12B isoform 2; protein phosphatase 1, regulatory (inhibitor) subunit 12B", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-2565942); (R-MMU-5625740); (R-MMU-5627123)", "pathway_count": 3, "publication_count": 21, "publication_id_list": "10.1101/2023.09.13.557529;17242355;19966500;21183079;21750661;22517741;22645316;30016717;32848054;33096475;34428180;34887587;35822049;36288343;36852467;36889588;37507081;38224947;38420846;40021952;40885482", "class_list": "", "function": "Epistatic evidence for gender-dependant slow neurotransmission signalling in substance use disorders: PPP1R12B versus PPP1R1B., [RefSeq, PubMed]; MYPT2 is truly the regulatory subunit of cardiac myosin phosphatase in-vivo and plays a significant role in modulating cardiac function., [RefSeq, PubMed]; Myosin Light Chain Phosphatase Plays an Important Role in Cardiac Fibrosis in a Model of Mineralocorticoid Receptor-Associated Hypertension., [RefSeq, PubMed]; Phosphatase regulatory subunit MYPT2 knockout partially compensates for the cardiac dysfunction in mice caused by lack of myosin light chain kinase 3., [RefSeq, PubMed]; Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus (By similarity)., [UniProtKB]; The MYPT2-regulated striated muscle-specific myosin light chain phosphatase limits cardiac myosin phosphorylation in vivo., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q8BXY7;Q9D8S6", "ec_number_list": [], "go_molecular_function": "GO:0017020 myosin phosphatase regulator activity;GO:0004857 enzyme inhibitor activity;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0001725 stress fiber;GO:0030018 Z disc;GO:0031672 A band", "go_biological_process": "GO:0007165 signal transduction;GO:0048812 neuron projection morphogenesis", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "Q8BG95-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R1S4-1", "uniprot_id": [ { "id": "MTSS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R1S4", "type": "external" } ], "mass": 82408.0, "length": 759, "protein_name": "Protein MTSS 1", "gene_name": "Mtss1", "organism": "Mouse", "refseq_name": "protein MTSS 1 isoform 1", "refseq_ac": [ { "id": "NP_659049", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659049", "type": "external" } ], "gene_names_uniprotkb": "Mtss1; Mim", "gene_names_refseq": "2310003N14Rik; D130001D01Rik; Mim; Mtss1; mKIAA0429", "protein_names_uniprotkb": "Protein MTSS 1; Metastasis suppressor protein 1; Missing in metastasis protein", "protein_names_refseq": "actin monomer-binding protein; metastasis suppressor 1; metastasis suppressor protein 1; missing in metastasis protein; protein MTSS 1 isoform 1; protein MTSS 1", "tax_id": 10090, "disease": "non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); intellectual developmental disorder with ocular anomalies and distinctive facial features (Disease Ontology:DOID:0081301)", "pathway": " (mmu:211401)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "12482861;17224454;17242355;20173027;21183079;21750661;25428506;30016717;30059200;30084848;32442560;32782141;33782537;34428180;34678516;35094173;36852467;38526535;40021952;40885482;40997131", "class_list": "", "function": "Downregulation of MTSS1 in acute myeloid leukemia is associated with a poor prognosis, chemotherapy resistance, and disease aggressiveness., [RefSeq, PubMed]; Inhibits the nucleation of actin filaments in vitro., [UniProtKB, PubMed]; LncRNA Mtss1 promotes inflammatory responses and secondary brain injury after intracerebral hemorrhage by targeting miR-709 in mice., [RefSeq, PubMed]; Metastasis suppressor 1 controls osteoblast differentiation and bone homeostasis through regulating Src-Wnt/beta-catenin signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Repulsive Sema3E-Plexin-D1 signaling coordinates both axonal extension and steering via activating an autoregulatory factor, Mtss1. Publication Status: Online-Only, [RefSeq, PubMed]; Tissue-specific regulator of cytoskeletal dynamics that interacts with ATP-actin monomers through its C-terminal WH2 domain, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q8BMM3;Q99LB3", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0003785 actin monomer binding;GO:0005102 signaling receptor binding;GO:0005543 phospholipid binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005912 adherens junction;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0032233 positive regulation of actin filament bundle assembly;GO:0001701 in utero embryonic development;GO:0007009 plasma membrane organization;GO:0007015 actin filament organization;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q8R1S4-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VCR8-1", "uniprot_id": [ { "id": "MYLK2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VCR8", "type": "external" } ], "mass": 65990.0, "length": 613, "protein_name": "Myosin light chain kinase 2, skeletal/cardiac muscle", "gene_name": "Mylk2", "organism": "Mouse", "refseq_name": "myosin light chain kinase 2, skeletal/cardiac muscle", "refseq_ac": [ { "id": "NP_001074513", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074513", "type": "external" } ], "gene_names_uniprotkb": "Mylk2", "gene_names_refseq": "9830004H17Rik; Mylk2", "protein_names_uniprotkb": "Myosin light chain kinase 2, skeletal/cardiac muscle; 2.7.11.18; MLCK2", "protein_names_refseq": "MLCK2; myosin light chain kinase 2, skeletal/cardiac muscle", "tax_id": 10090, "disease": "hypertrophic cardiomyopathy 1 (Disease Ontology:DOID:0110307)", "pathway": " (mmu:228785)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16299103;18279813;21183079;39927985", "class_list": "", "function": "Ca(2+)/calmodulin-dependent kinase that phosphorylates the regulatory light chain (RLC) of sarcomeric myosin in skeletal and cardiac muscle. Phosphorylation of RLC promotes displacement of myosin cross-bridges from the thick filament backbone toward actin-containing thin filaments, increasing the probability of cross-bridge entry into force-generating states and thereby potentiating contractile force at submaximal Ca(2+) concentrations., [UniProtKB, PubMed]; These data reveal that nmMLCK2 overexpression in the endothelium exacerbates lung injury in vivo in a sexually dimorphic and age-dependent manner., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2APB9", "ec_number_list": [ { "id": "2.7.11.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.18", "type": "external" } ], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0032027 myosin light chain binding;GO:0004687 myosin light chain kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0014816 skeletal muscle satellite cell differentiation;GO:0006468 protein phosphorylation;GO:0007165 signal transduction;GO:0007274 neuromuscular synaptic transmission;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8VCR8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQ19-1", "uniprot_id": [ { "id": "MYL9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQ19", "type": "external" } ], "mass": 19854.0, "length": 172, "protein_name": "Myosin regulatory light polypeptide 9", "gene_name": "Myl9", "organism": "Mouse", "refseq_name": "myosin regulatory light polypeptide 9 isoform a", "refseq_ac": [ { "id": "NP_742116", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742116", "type": "external" } ], "gene_names_uniprotkb": "Myl9; Myrl2", "gene_names_refseq": "MLC20; Myl9; Mylc2c; RLC-C", "protein_names_uniprotkb": "Myosin regulatory light polypeptide 9; Myosin regulatory light chain 2, smooth muscle isoform; Myosin regulatory light chain 9", "protein_names_refseq": "myosin light chain, regulatory C; myosin regulatory light chain 9; myosin regulatory light polypeptide 9 isoform a; myosin regulatory light polypeptide 9", "tax_id": 10090, "disease": "megacystis-microcolon-intestinal hypoperistalsis syndrome (Disease Ontology:DOID:0060610); familial hypertrophic cardiomyopathy (Disease Ontology:DOID:0080326)", "pathway": " (mmu:98932); (R-MMU-445355); (R-MMU-5627123)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "17015463;20956536;24825904;29799007;37507081;37828378", "class_list": "", "function": "Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity). In myoblasts, regulates PIEZO1-dependent cortical actomyosin assembly involved in myotube formation (PubMed:29799007)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TW15;Q80X77", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005509 calcium ion binding;GO:0032036 myosin heavy chain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005938 cell cortex;GO:0001725 stress fiber;GO:0030018 Z disc;GO:0030016 myofibril", "go_biological_process": "GO:0043149 stress fiber assembly;GO:0030239 myofibril assembly", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9CQ19-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CZH7-1", "uniprot_id": [ { "id": "MXRA7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CZH7", "type": "external" } ], "mass": 19458.0, "length": 178, "protein_name": "Matrix-remodeling-associated protein 7", "gene_name": "Mxra7", "organism": "Mouse", "refseq_name": "matrix-remodeling-associated protein 7 isoform 1", "refseq_ac": [ { "id": "NP_080556", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080556", "type": "external" } ], "gene_names_uniprotkb": "Mxra7", "gene_names_refseq": "1810057P16Rik; E130302J09Rik; Mxra7", "protein_names_uniprotkb": "Matrix-remodeling-associated protein 7", "protein_names_refseq": "matrix-remodeling-associated protein 7 isoform 1; matrix-remodeling-associated protein 7; transmembrane anchor protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67622)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15345747;17114649;17242355;18630941;21183079;28847716;30843215;35680791", "class_list": "", "function": "MXRA7 influences bone formation by regulating the balance between osteogenesis and adipogenesis in bone marrow mesenchymal stem cells. GeneRIF: MXRA7 influences bone formation via regulating the balance between osteogenesis and adipogenesis in bone marrow mesenchymal stem cells. Deficiency of MXRA7 in mice leads to shorter tibia., [RefSeq, PubMed]; MXRA7 is under-expressed during corneal infection and neovascularization., [RefSeq, PubMed]; [The Effect of Matrix Remodeling Associated 7 (MXRA7) Expression on the Biological Function of SHI-1 Cells]., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AA24;B2RVR9;Q8C6F8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0030219 megakaryocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9CZH7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JMH9-3", "uniprot_id": [ { "id": "MY18A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JMH9", "type": "external" } ], "mass": 232755.0, "length": 2050, "protein_name": "Unconventional myosin-XVIIIa", "gene_name": "Myo18a", "organism": "Mouse", "refseq_name": "unconventional myosin-XVIIIa isoform 3", "refseq_ac": [ { "id": "NP_001278141", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278141", "type": "external" } ], "gene_names_uniprotkb": "Myo18a; Myspdz", "gene_names_refseq": "MAJN; Myo18a; MyoPDZ; MysPDZ; SP-R210", "protein_names_uniprotkb": "Unconventional myosin-XVIIIa; MAJN; Molecule associated with JAK3 N-terminus; Myosin containing a PDZ domain; SP-R210; Surfactant protein receptor SP-R210", "protein_names_refseq": "molecule associated with JAK3 N-terminus; myosin XVIIIb; myosin containing a PDZ domain; surfactant protein receptor SP-R210; unconventional myosin-XVIIIa isoform 3; unconventional myosin-XVIIIa", "tax_id": 10090, "disease": "", "pathway": " (mmu:360013)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "10.1101/2023.09.13.557529;10733906;10733938;12761286;14969583;15582604;16087679;16452087;17242355;18630941;19837035;21123169;21183079;25428506;25965346;30084848;31599954;34001658;34428180;34735924;38092135;38349123;39627609", "class_list": "", "function": "Cutting Edge: Myosin 18A Is a Novel Checkpoint Regulator in B Cell Differentiation and Antibody-Mediated Immunity., [RefSeq, PubMed]; Disruption of the SP-A/SP-R210L (MYO18Aalpha) pathway prolongs gestation and reduces fetal survival during lipopolysaccharide-induced parturition in late gestation., [RefSeq, PubMed]; Genomic and epigenomic adaptation in SP-R210 (Myo18A) isoform-deficient macrophages., [RefSeq, PubMed]; May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (By similarity). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (PubMed:10733906). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Tanc1/2 TPR domain interacts with Myo18a C-terminus and undergoes liquid-liquid phase separation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 33, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TBB2;Q3UH48;Q3UV60;Q5QD54;Q5QD55;Q5QD56;Q5SYN8;Q5SYN9;Q5SYP0;Q5SYP1;Q811D7", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0043531 ADP binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005903 brush border;GO:0005815 microtubule organizing center", "go_biological_process": "GO:0090164 asymmetric Golgi ribbon formation;GO:0016477 cell migration;GO:0043066 negative regulation of apoptotic process;GO:0050714 positive regulation of protein secretion;GO:0031032 actomyosin structure organization", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q9JMH9-3", "record_type": "protein", "filter_code": "0000000.1100101.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80XJ3-1", "uniprot_id": [ { "id": "TTC28_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80XJ3", "type": "external" } ], "mass": 267459.0, "length": 2450, "protein_name": "Tetratricopeptide repeat protein 28", "gene_name": "Ttc28", "organism": "Mouse", "refseq_name": "tetratricopeptide repeat protein 28", "refseq_ac": [ { "id": "NP_001254551", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001254551", "type": "external" } ], "gene_names_uniprotkb": "Ttc28; Kiaa1043; Tprbk", "gene_names_refseq": "2310015L07Rik; 6030435N04; TPRBK; Ttc28", "protein_names_uniprotkb": "Tetratricopeptide repeat protein 28; TPR repeat protein 28", "protein_names_refseq": "TPR repeat protein 28; tetratricopeptide repeat protein 28", "tax_id": 10090, "disease": "", "pathway": " (mmu:209683)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "21183079;21750661;22872234;23036704;25428506;30084848;32782141;34428180", "class_list": "", "function": "During mitosis, may be involved in the condensation of spindle midzone microtubules, leading to the formation of midbody., [UniProtKB, UniProtKB, UniProtKB]; Essential for the formation and integrity of the midbody. Max play a critical role in the progress of mitosis and cytokinesis during cell cycle (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "J3QM46;J3QQ36;Q6P9J6;Q80TL5;Q8BV10;Q8C0F2", "ec_number_list": [], "go_molecular_function": "GO:0019900 kinase binding", "go_cellular_component": "GO:0005813 centrosome;GO:0030496 midbody;GO:0097431 mitotic spindle pole;GO:0072686 mitotic spindle;GO:1990023 mitotic spindle midzone", "go_biological_process": "GO:0051301 cell division;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q80XJ3-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80UG8-1", "uniprot_id": [ { "id": "TTLL4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80UG8", "type": "external" } ], "mass": 132530.0, "length": 1193, "protein_name": "Tubulin monoglutamylase TTLL4", "gene_name": "Ttll4", "organism": "Mouse", "refseq_name": "tubulin monoglutamylase TTLL4", "refseq_ac": [ { "id": "NP_001014974", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014974", "type": "external" } ], "gene_names_uniprotkb": "Ttll4; Kiaa0173", "gene_names_refseq": "4632407P03Rik; Ttll4; mKIAA0173", "protein_names_uniprotkb": "Tubulin monoglutamylase TTLL4; 6.3.2.-; Protein monoglutamylase TTLL4; Tubulin--tyrosine ligase-like protein 4", "protein_names_refseq": "protein monoglutamylase TTLL4; tubulin monoglutamylase TTLL4; tubulin polyglutamylase TTLL4; tubulin--tyrosine ligase-like protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:67534); (R-MMU-8955332)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "17499049;20530212;21074048;21750661;23897886;25428506;26829768;29593216", "class_list": "", "function": "Monoglutamylase which modifies both tubulin and non-tubulin proteins, adding a single glutamate on the gamma-carboxyl group of specific glutamate residues of target proteins (PubMed:17499049, PubMed:20530212, PubMed:21074048, PubMed:26829768). Involved in the side-chain initiation step of the polyglutamylation reaction but not in the elongation step (PubMed:17499049, PubMed:21074048). Preferentially modifies beta-tail tubulin over the alpha-tubulin (PubMed:17499049). Monoglutamylates nucleosome assembly proteins NAP1L1 and NAP1L4 (PubMed:17499049). Monoglutamylates nucleotidyltransferase CGAS, leading to inhibition of CGAS catalytic activity, thereby preventing antiviral defense function (PubMed:26829768). Involved in KLF4 glutamylation which impedes its ubiquitination, thereby leading to somatic cell reprogramming, pluripotency maintenance and embryogenesis (PubMed:29593216)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A4Q9E6;Q5U4C4", "ec_number_list": [ { "id": "6.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.-", "type": "external" }, { "id": "6.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.-.-.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" } ], "go_molecular_function": "GO:0070740 tubulin-glutamic acid ligase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0015631 tubulin binding;GO:0070739 protein-glutamic acid ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0036064 ciliary basal body;GO:0097731 9+0 non-motile cilium", "go_biological_process": "GO:0000226 microtubule cytoskeleton organization;GO:0018095 protein polyglutamylation;GO:0018200 peptidyl-glutamic acid modification;GO:0120222 regulation of blastocyst development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q80UG8-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08970-1", "uniprot_id": [ { "id": "TUFT1_MOUSE", "url": "https://www.uniprot.org/uniprot/O08970", "type": "external" } ], "mass": 44576.0, "length": 390, "protein_name": "Tuftelin", "gene_name": "Tuft1", "organism": "Mouse", "refseq_name": "tuftelin isoform 1", "refseq_ac": [ { "id": "NP_035786", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035786", "type": "external" } ], "gene_names_uniprotkb": "Tuft1", "gene_names_refseq": "Tuft1", "protein_names_uniprotkb": "Tuftelin", "protein_names_refseq": "tuftelin isoform 1", "tax_id": 10090, "disease": "palmoplantar keratosis (Disease Ontology:DOID:3390)", "pathway": " (mmu:22156)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10806191;11733143;21285247;21750661;34428180;35820561;36689522;37716648;38105232;9074935;9839784", "class_list": "", "function": "Biallelic TUFT1 variants cause woolly hair, superficial skin fragility and desmosomal defects., [RefSeq, PubMed]; Disruption of TUFT1, a Desmosome-Associated Protein, Causes Skin Fragility, Woolly Hair, and Palmoplantar Keratoderma., [RefSeq, PubMed]; Involved in the structural organization of the epidermis (By similarity). Involved in the mineralization and structural organization of enamel., [UniProtKB, UniProtKB, UniProtKB]; The phosphorylation of serine(55) in enamelin is essential for murine amelogenesis., [RefSeq, PubMed]; Tuftelin is an acidic protein that is thought to play a role in dental enamel mineralization and is implicated in caries susceptibility. It is also thought to be involved with adaptation to hypoxia, mesenchymal stem cell function, and neurotrophin nerve growth factor mediated neuronal differentiation. [provided by RefSeq, Aug 2014]., [RefSeq]; Tuftelin1 drives experimental pulmonary fibrosis progression by facilitating stress fiber assembly. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0031674 I band;GO:0005665 RNA polymerase II, core complex", "go_biological_process": "GO:0031214 biomineral tissue development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O08970-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88196-1", "uniprot_id": [ { "id": "TTC3_MOUSE", "url": "https://www.uniprot.org/uniprot/O88196", "type": "external" } ], "mass": 223931.0, "length": 1979, "protein_name": "E3 ubiquitin-protein ligase TTC3", "gene_name": "Ttc3", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ttc3; Kiaa4119", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TTC3; 2.3.2.27; Mtprd; RING-type E3 ubiquitin transferase TTC3; TPR repeat protein D", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:22129)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;22872234;25428506;30084848;30899004;31219806;34428180;9603993", "class_list": "", "function": "E3 ubiquitin-protein ligase which catalyzes the formation of 'Lys-48'-polyubiquitin chains (By similarity). Mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus (By similarity). Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation (By similarity). Positively regulates TGFB1-induced epithelial-mesenchymal transition and myofibroblast differentiation by mediating the ubiquitination and subsequent degradation of SMURF2 (By similarity). Regulates neuronal differentiation by regulating actin remodeling and Golgi organization via a signaling cascade involving RHOA, CIT and ROCK (By similarity). Inhibits cell proliferation (By similarity)., [UniProtKB, UniProtKB]; E3 ubiquitin-protein ligase which catalyzes the formation of 'Lys-48'-polyubiquitin chains. Mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus. Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation. Positively regulates TGFB1-induced epithelial-mesenchymal transition and myofibroblast differentiation by mediating the ubiquitination and subsequent degradation of SMURF2. Regulates neuronal differentiation by regulating actin remodeling and Golgi organization via a signaling cascade involving RHOA, CIT and ROCK. Inhibits cell proliferation., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q05D15;Q3TMM9;Q3TPC8;Q3TPV5;Q3TQL0;Q3TSK0;Q3UFH5;Q5DTM5;Q6PG61;Q8BPM4;Q8C2N6", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0006511 ubiquitin-dependent protein catabolic process;GO:0070936 protein K48-linked ubiquitination;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "O88196-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TH73-1", "uniprot_id": [ { "id": "TTYH2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TH73", "type": "external" } ], "mass": 59008.0, "length": 532, "protein_name": "Protein tweety homolog 2", "gene_name": "Ttyh2", "organism": "Mouse", "refseq_name": "protein tweety homolog 2", "refseq_ac": [ { "id": "NP_444503", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444503", "type": "external" } ], "gene_names_uniprotkb": "Ttyh2", "gene_names_refseq": "1110001A03Rik; Ttyh2", "protein_names_uniprotkb": "Protein tweety homolog 2; Volume-regulated anion channel subunit Ttyh2; mTTY2", "protein_names_refseq": "mTTY2; protein tweety homolog 2; tweety homolog 2; volume-regulated anion channel subunit Ttyh2", "tax_id": 10090, "disease": "", "pathway": " (mmu:117160); (R-MMU-2672351)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "11597145;21183079;26740625;30084848;31138989;31219806;34824283;35820727", "class_list": "", "function": "Calcium-independent, swelling-dependent volume-regulated anion channel (VRAC-swell) which plays a pivotal role in the process of regulatory volume decrease (RVD) in the brain through the efflux of anions like chloride and organic osmolytes like glutamate (PubMed:31138989). Probable large-conductance Ca(2+)-activated chloride channel (By similarity)., [UniProtKB, UniProtKB, PubMed]; Structures of tweety homolog proteins TTYH2 and TTYH3 reveal a Ca(2+)-dependent switch from intra- to intermembrane dimerization. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3U103;Q3U8L3;Q6P9J3;Q920A8", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0072320 volume-sensitive chloride channel activity;GO:0005509 calcium ion binding;GO:0005229 intracellularly calcium-gated chloride channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0034707 chloride channel complex", "go_biological_process": "GO:0015813 L-glutamate transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q3TH73-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61037-1", "uniprot_id": [ { "id": "TSC2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61037", "type": "external" } ], "mass": 202071.0, "length": 1814, "protein_name": "Tuberin", "gene_name": "Tsc2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Tsc2", "gene_names_refseq": "", "protein_names_uniprotkb": "Tuberin; Tuberous sclerosis 2 protein homolog", "protein_names_refseq": "", "tax_id": 10090, "disease": "medulloblastoma (Disease Ontology:DOID:0050902); autism spectrum disorder (Disease Ontology:DOID:0060041); tuberous sclerosis 2 (Disease Ontology:DOID:0080325); Alzheimer's disease (Disease Ontology:DOID:10652); leiomyoma (Disease Ontology:DOID:127); uterine fibroid (Disease Ontology:DOID:13223); tuberous sclerosis (Disease Ontology:DOID:13515); breast cancer (Disease Ontology:DOID:1612); anxiety disorder (Disease Ontology:DOID:2030); angiomyolipoma (Disease Ontology:DOID:3314); hepatic angiomyolipoma (Disease Ontology:DOID:3317); lymphangioleiomyomatosis (Disease Ontology:DOID:3319); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (R-MMU-1632852); (R-MMU-165181); (R-MMU-198323); (R-MMU-380972); (R-MMU-5628897); (R-MMU-8854214)", "pathway_count": 6, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;10584558;12150915;12820960;15851026;16707451;17242355;20412061;21183079;21750661;24529379;26495903;31219806;34203471;34428180;36210013;8777431;8833243;9743625", "class_list": "", "function": "Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12820960, PubMed:24529379). Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12820960, PubMed:24529379). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12820960, PubMed:24529379). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:24529379). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (PubMed:16707451). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 27, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 15, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "P97723;P97724;P97725;P97727;Q61007;Q61008;Q9WUF6", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0042803 protein homodimerization activity;GO:0044877 protein-containing complex binding;GO:0031267 small GTPase binding;GO:0071889 14-3-3 protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0033596 TSC1-TSC2 complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0048550 negative regulation of pinocytosis;GO:1904263 positive regulation of TORC1 signaling;GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0098976 excitatory chemical synaptic transmission;GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q61037-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P5F7-1", "uniprot_id": [ { "id": "TTYH3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P5F7", "type": "external" } ], "mass": 57714.0, "length": 524, "protein_name": "Protein tweety homolog 3", "gene_name": "Ttyh3", "organism": "Mouse", "refseq_name": "protein tweety homolog 3 isoform 3", "refseq_ac": [ { "id": "NP_001294969", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001294969", "type": "external" } ], "gene_names_uniprotkb": "Ttyh3; Kiaa1691", "gene_names_refseq": "2900029G13Rik; TTY3; Ttyh3; mTTY3", "protein_names_uniprotkb": "Protein tweety homolog 3; Volume-regulated anion channel subunit Ttyh3; mTTY3", "protein_names_refseq": "protein tweety homolog 3 isoform 3; protein tweety homolog 3; volume-regulated anion channel subunit Ttyh3", "tax_id": 10090, "disease": "", "pathway": " (mmu:78339); (R-MMU-2672351)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;15010458;19144319;20624691;21183079;21750661;22534482;26495903;26740625;28011936;30899004;31138989;33300544;34428180;34824283;36042377", "class_list": "", "function": "Calcium-independent, swelling-dependent volume-regulated anion channel (VRAC-swell) which plays a pivotal role in the process of regulatory volume decrease (RVD) in the brain through the efflux of anions like chloride and organic osmolytes like glutamate (PubMed:31138989). Probable large-conductance Ca(2+)-activated chloride channel (By similarity)., [UniProtKB, UniProtKB, PubMed]; Down-regulation of mTTYH3 may point towards its involvement in complex cystic fibrosis pathology. However, markedly reduced expression argues against direct compensatory action as alternative anion conductance., [RefSeq, PubMed]; Structures of tweety homolog proteins TTYH2 and TTYH3 reveal a Ca(2+)-dependent switch from intra- to intermembrane dimerization. Publication Status: Online-Only, [RefSeq, PubMed]; This study demonistrated that Ttyh3 gene expression in mouse dorsal raphe nucleus, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q69ZD3;Q6PCX0;Q8C789", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0072320 volume-sensitive chloride channel activity;GO:0005509 calcium ion binding;GO:0005229 intracellularly calcium-gated chloride channel activity;GO:0005254 chloride channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0034707 chloride channel complex", "go_biological_process": "GO:0006821 chloride transport;GO:0015813 L-glutamate transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q6P5F7-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.1100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CEG8-1", "uniprot_id": [ { "id": "UBP27_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CEG8", "type": "external" } ], "mass": 49599.0, "length": 438, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 27", "gene_name": "Usp27x", "organism": "Mouse", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 27", "refseq_ac": [ { "id": "NP_062334", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062334", "type": "external" } ], "gene_names_uniprotkb": "Usp27x; Usp27", "gene_names_refseq": "Sfc11; Usp27x; Usp27", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 27; 3.4.19.12; Deubiquitinating enzyme 27; Ubiquitin thioesterase 27; Ubiquitin-specific-processing protease 27; X-linked ubiquitin carboxyl-terminal hydrolase 27", "protein_names_refseq": "X-linked ubiquitin carboxyl-terminal hydrolase 27; X-linked ubiquitin thioesterase 27; deubiquitinating enzyme 27; ubiquitin carboxyl-terminal hydrolase 27; ubiquitin specific protease 27, X chromosome; ubiquitin thiolesterase 27; ubiquitin-specific-processing protease 27", "tax_id": 10090, "disease": "non-syndromic X-linked intellectual disability 105 (Disease Ontology:DOID:0112036); glioblastoma (Disease Ontology:DOID:3068)", "pathway": " (mmu:54651)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10857745;20484733;27013495;31219806;31534008;32027733;34203471;34428180;36210013", "class_list": "", "function": "Deubiquitinase involved in innate antiviral immunity by mediating deubiquitination of CGAS and RIGI (PubMed:31534008). Negatively regulates RIGI by mediating 'Lys-63'-linked deubiquitination of RIGI, inhibiting type I interferon signaling (By similarity). Also regulates 'Lys-63'-linked ubiquitination level of MDA5/IFIH1 (By similarity). Acts as a positive regulator of the cGAS-STING pathway by catalyzing 'Lys-48'-linked deubiquitination of CGAS, thereby promoting its stabilization (PubMed:31534008). Can reduce the levels of BCL2L11/BIM ubiquitination and stabilize BCL2L11 in response to the RAF-MAPK-degradation signal (PubMed:27013495). By acting on BCL2L11 levels, may counteract the anti-apoptotic effects of MAPK activity (PubMed:27013495)., [UniProtKB, PubMed, UniProtKB, PubMed]; These studies uncover a novel negative regulatory role of USP27X in targeting RIG-I to balance innate immune responses. Publication Status: Online-Only, [RefSeq, PubMed]; Usp27x can trigger via its proteolytic activity the deubiquitination of Bim and enhance its levels, counteracting the anti-apoptotic effects of ERK activity, and therefore acts as a tumour suppressor., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1ATV2;Q8BSW2;Q9JIG5", "ec_number_list": [], "go_molecular_function": "GO:0004197 cysteine-type endopeptidase activity;GO:0004843 cysteine-type deubiquitinase activity;GO:0061578 K63-linked deubiquitinase activity;GO:1990380 K48-linked deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0043065 positive regulation of apoptotic process;GO:0045087 innate immune response;GO:0051607 defense response to virus", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8CEG8-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K387-1", "uniprot_id": [ { "id": "UBP45_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K387", "type": "external" } ], "mass": 90361.0, "length": 813, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 45", "gene_name": "Usp45", "organism": "Mouse", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 45 isoform 2", "refseq_ac": [ { "id": "NP_001277354", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277354", "type": "external" } ], "gene_names_uniprotkb": "Usp45", "gene_names_refseq": "3110003C05Rik; 4930550B20Rik; Gcap7; Usp45", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 45; 3.4.19.12; Deubiquitinating enzyme 45; Ubiquitin thioesterase 45; Ubiquitin-specific-processing protease 45", "protein_names_refseq": "deubiquitinating enzyme 45; granule cell antiserum positive 7; ubiquitin carboxyl-terminal hydrolase 45 isoform 2; ubiquitin carboxyl-terminal hydrolase 45; ubiquitin specific protease 45; ubiquitin thioesterase 45; ubiquitin thiolesterase 45; ubiquitin-specific-processing protease 45", "tax_id": 10090, "disease": "Leber congenital amaurosis 19 (Disease Ontology:DOID:0081169)", "pathway": " (mmu:77593); (R-MMU-5696395)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "21183079;21750661;25538220;27613029;30573563;31219806;34203471;34418053;34428180;36210013", "class_list": "", "function": "Catalyzes the deubiquitination of SPDL1 (By similarity). Plays a role in the repair of UV-induced DNA damage via deubiquitination of ERCC1, promoting its recruitment to DNA damage sites (By similarity). May be involved in the maintenance of photoreceptor function (PubMed:30573563). May play a role in normal retinal development (By similarity). Plays a role in cell migration (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; These results establish USP45 as a new regulator of XPF-ERCC1 crucial for efficient DNA repair, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AJT1;Q8BU19;Q8BZ19", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0001917 photoreceptor inner segment", "go_biological_process": "GO:0003407 neural retina development;GO:0006281 DNA repair;GO:0006508 proteolysis;GO:0016477 cell migration;GO:0016579 protein deubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8K387-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VD72-1", "uniprot_id": [ { "id": "TTC8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VD72", "type": "external" } ], "mass": 58440.0, "length": 515, "protein_name": "Tetratricopeptide repeat protein 8", "gene_name": "Ttc8", "organism": "Mouse", "refseq_name": "tetratricopeptide repeat protein 8 isoform 2", "refseq_ac": [ { "id": "NP_083829", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083829", "type": "external" } ], "gene_names_uniprotkb": "Ttc8; Bbs8", "gene_names_refseq": "0610012F22Rik; BBS8; Ttc8", "protein_names_uniprotkb": "Tetratricopeptide repeat protein 8; Bardet-Biedl syndrome 8 protein homolog; TPR repeat protein 8", "protein_names_refseq": "TPR repeat protein 8; bardet-Biedl syndrome 8 protein homolog; tetratricopeptide repeat protein 8 isoform 2; tetratricopeptide repeat protein 8", "tax_id": 10090, "disease": "ciliopathy (Disease Ontology:DOID:0060340); Bardet-Biedl syndrome 8 (Disease Ontology:DOID:0110130); retinitis pigmentosa 51 (Disease Ontology:DOID:0110398); Bardet-Biedl syndrome (Disease Ontology:DOID:1935)", "pathway": " (mmu:76260); (R-MMU-5620922)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "14520415;20451172;21750661;22072986;25243405", "class_list": "", "function": "The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9DCP7", "ec_number_list": [], "go_molecular_function": "GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005929 cilium;GO:0016020 membrane;GO:0001650 fibrillar center;GO:0005814 centriole", "go_biological_process": "GO:1903251 multi-ciliated epithelial cell differentiation;GO:0061326 renal tubule development;GO:0015031 protein transport;GO:0045198 establishment of epithelial cell apical/basal polarity;GO:0072659 protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8VD72-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D2E1-1", "uniprot_id": [ { "id": "TSSK3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D2E1", "type": "external" } ], "mass": 30209.0, "length": 268, "protein_name": "Testis-specific serine/threonine-protein kinase 3", "gene_name": "Tssk3", "organism": "Mouse", "refseq_name": "testis-specific serine/threonine-protein kinase 3", "refseq_ac": [ { "id": "NP_536690", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_536690", "type": "external" } ], "gene_names_uniprotkb": "Tssk3; Stk22c; Stk22d", "gene_names_refseq": "1700014N07Rik; 4930594I21Rik; Stk22c; Stk22d; Tsk-3; Tssk-3; Tssk3b; Tssk3", "protein_names_uniprotkb": "Testis-specific serine/threonine-protein kinase 3; 2.7.11.1; Serine/threonine-protein kinase 22C; TSK-3; TSSK-3; Testis-specific kinase 3", "protein_names_refseq": "serine/threonine kinase 22C (spermiogenesis associated); serine/threonine-protein kinase 22C; spermiogenesis associated serine/threonine kinase 22D; testis-specific kinase 3; testis-specific serine/threonine kinase 3b; testis-specific serine/threonine-protein kinase 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:58864)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10781952;11597141;16336268;34623009;36306217", "class_list": "", "function": "PDK1-induced phosphorylation increased in vitro TSSK3 kinase activity, suggesting that TSSK3 can be regulated in the same way as AGC kinase family members. The peptide sequence RRSSSY containing Ser5 is identified as a target for TSSK3 phosphorylation, [RefSeq, PubMed]; Serine/threonine protein kinase required for spermatid development and male fertility., [UniProtKB, PubMed, PubMed]; Testis-specific serine kinase 3 is required for sperm morphogenesis and male fertility., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JL98", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0030145 manganese ion binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0036126 sperm flagellum", "go_biological_process": "GO:0007283 spermatogenesis;GO:0035556 intracellular signal transduction;GO:0007286 spermatid development;GO:0048240 sperm capacitation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9D2E1-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70480-1", "uniprot_id": [ { "id": "VAMP4_MOUSE", "url": "https://www.uniprot.org/uniprot/O70480", "type": "external" } ], "mass": 16353.0, "length": 141, "protein_name": "Vesicle-associated membrane protein 4", "gene_name": "Vamp4", "organism": "Mouse", "refseq_name": "vesicle-associated membrane protein 4 isoform 2", "refseq_ac": [ { "id": "NP_001334054", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334054", "type": "external" } ], "gene_names_uniprotkb": "Vamp4", "gene_names_refseq": "D1Ertd147e; Vamp-4; Vamp4", "protein_names_uniprotkb": "Vesicle-associated membrane protein 4; VAMP-4", "protein_names_refseq": "vesicle-associated membrane protein 4 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:53330); (R-MMU-6811440); (R-MMU-8856825); (R-MMU-8856828)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "12682051;15345747;17159904;17242355;18630941;19131326;19144319;21183079;21750661;25428506;28770820;38198890", "class_list": "", "function": "SNAREs (soluble N-ethylmaleimide-sensitive factor-attachment protein receptors) are essential proteins for intracellular membrane fusion. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four-helix bundle whose assembly releases energy that drives membrane fusion. The core SNARE complex typically consists of four alpha-helical domains, three from target membrane SNAREs (t-SNAREs) and one from a vesicle SNARE (v-SNARE) (PubMed:17159904, PubMed:38198890). VAMP4 is a v-SNARE that functions in vesicle fusion with the plasma membrane. In skeletal muscle satellite cells, VAMP4 cooperates with its cognate SNAREs STX11 and SNAP23 to facilitate CD36 vesicular transport from endosomes to the plasma membrane, an essential step in muscle regeneration (PubMed:38198890)., [UniProtKB, PubMed, PubMed]; The cytoplasmic domain of this protein is responsible for its correct subcellular targeting, the N-terminal extension contains a dominant autonomous targeting signal for the trans-golgi network, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D095", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005794 Golgi apparatus;GO:0009986 cell surface;GO:0045335 phagocytic vesicle;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0042996 regulation of Golgi to plasma membrane protein transport;GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane;GO:0043001 Golgi to plasma membrane protein transport;GO:0071346 cellular response to type II interferon;GO:0090161 Golgi ribbon formation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O70480-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80Z96-1", "uniprot_id": [ { "id": "VANG1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80Z96", "type": "external" } ], "mass": 60064.0, "length": 526, "protein_name": "Vang-like protein 1", "gene_name": "Vangl1", "organism": "Mouse", "refseq_name": "vang-like protein 1", "refseq_ac": [ { "id": "NP_808213", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808213", "type": "external" } ], "gene_names_uniprotkb": "Vangl1; Lpp2", "gene_names_refseq": "Kitenin; Lpp2; Stb2; Stbm; Vangl1", "protein_names_uniprotkb": "Vang-like protein 1; Loop-tail protein 2; Van Gogh-like protein 1", "protein_names_refseq": "KAI1 COOH-terminal interacting tetraspanin; loop-tail protein 2; strabismus; van Gogh-like protein 1; vang, van gogh-like 1; vang-like 1 (van gogh, Drosophila); vang-like protein 1", "tax_id": 10090, "disease": "neural tube defect (Disease Ontology:DOID:0080074); caudal regression syndrome (Disease Ontology:DOID:0080700)", "pathway": " (mmu:229658); (R-MMU-8980692); (R-MMU-9013026); (R-MMU-9013106); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013406); (R-MMU-9013407); (R-MMU-9013408); (R-MMU-9013420); (R-MMU-9013423); (R-MMU-9013424); (R-MMU-9035034); (R-MMU-9696264); (R-MMU-9696270); (R-MMU-9696273)", "pathway_count": 16, "publication_count": 6, "publication_id_list": "15456783;21183079;21750661;23029439;38569553;39225402", "class_list": "", "function": "Mesenchymal Vangl1 and Vangl2 facilitate airway elongation and widening independently of the planar cell polarity complex., [RefSeq, PubMed]; Vangl-dependent mesenchymal thinning shapes the distal lung during murine sacculation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RRP5;Q8QZT3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016328 lateral plasma membrane", "go_biological_process": "GO:0043473 pigmentation;GO:0120197 mucociliary clearance", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q80Z96-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BLE7-1", "uniprot_id": [ { "id": "VGLU2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BLE7", "type": "external" } ], "mass": 64561.0, "length": 582, "protein_name": "Vesicular glutamate transporter 2", "gene_name": "Slc17a6", "organism": "Mouse", "refseq_name": "vesicular glutamate transporter 2 isoform 1", "refseq_ac": [ { "id": "NP_543129", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_543129", "type": "external" } ], "gene_names_uniprotkb": "Slc17a6; Dnpi; Vglut2", "gene_names_refseq": "2900073D12Rik; DNPI; Slc17a6; VGLUT2", "protein_names_uniprotkb": "Vesicular glutamate transporter 2; Differentiation-associated BNPI; Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter; Solute carrier family 17 member 6; VGluT2", "protein_names_refseq": "differentiation-associated BNPI; differentiation-associated Na(+)-dependent inorganic phosphate cotransporter; solute carrier family 17 (vesicular glutamate transporter), member 6; solute carrier family 17 member 6; vesicular glutamate transporter 2 isoform 1; vesicular glutamate transporter 2", "tax_id": 10090, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330); transient cerebral ischemia (Disease Ontology:DOID:224)", "pathway": " (mmu:140919); (R-MMU-442660)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;11432869;12384506;12698357;12823463;14614902;15103023;15118123;16942593;17108179;21750661;25433636;30936473;33440152", "class_list": "", "function": "Mossy terminals of unipolar brush cells are immunoreactive for VGLUT2; moreover, dendritic brushes are contacted by mossy terminals expressing VGLUT2 in organotypic cultures of mouse vestibulocerebellum., [RefSeq, PubMed]; Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, proton, potassium, sodium and phosphate (PubMed:11432869, PubMed:17108179, PubMed:25433636, PubMed:33440152). At the synaptic vesicle membrane, mainly functions as a uniporter which transports preferentially L-glutamate but also, phosphate from the cytoplasm into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells (PubMed:11432869, PubMed:17108179). The L-glutamate or phosphate uniporter activity is electrogenic and is driven by the proton electrochemical gradient, mainly by the electrical gradient established by the vacuolar H(+)-ATPase across the synaptic vesicle membrane (PubMed:11432869). In addition, functions as a chloride channel that allows a chloride permeation through the synaptic vesicle membrane therefore affects the proton electrochemical gradient and promotes synaptic vesicles acidification (By similarity). Moreover, functions as a vesicular K(+)/H(+) antiport allowing to maintain the electrical gradient and to decrease chemical gradient and therefore sustain vesicular glutamate uptake (PubMed:25433636). The vesicular H(+)/H(+) antiport activity is electroneutral (PubMed:25433636). At the plasma membrane, following exocytosis, functions as a symporter of Na(+) and phosphate from the extracellular space to the cytoplasm allowing synaptic phosphate homeostasis regulation (PubMed:33440152). The symporter activity is driven by an inside negative membrane potential and is electrogenic (PubMed:33440152). Also involved in the regulation of retinal hyaloid vessel regression during postnatal development (PubMed:30936473). May also play a role in the endocrine glutamatergic system of other tissues such as pineal gland and pancreas (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Subtype switching of vesicular glutamate transporters at parallel fibre-Purkinje cell synapses in developing mouse cerebellum., [RefSeq, PubMed]; VGLUT2 is found in vagal afferent endings in the esophagus, suggesting that glutamate is contained in, and probably released from, synaptic vesicles previously described in intraganglionic laminar endings, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q920B7", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0005326 neurotransmitter transmembrane transporter activity;GO:0015386 potassium:proton antiporter activity;GO:0005254 chloride channel activity;GO:0005313 L-glutamate transmembrane transporter activity;GO:0005436 sodium:phosphate symporter activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0043005 neuron projection;GO:0030672 synaptic vesicle membrane;GO:0034707 chloride channel complex", "go_biological_process": "GO:1990384 hyaloid vascular plexus regression;GO:0050803 regulation of synapse structure or activity;GO:0035249 synaptic transmission, glutamatergic;GO:0055062 phosphate ion homeostasis;GO:0001504 neurotransmitter uptake", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q8BLE7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70404-1", "uniprot_id": [ { "id": "VAMP8_MOUSE", "url": "https://www.uniprot.org/uniprot/O70404", "type": "external" } ], "mass": 11451.0, "length": 101, "protein_name": "Vesicle-associated membrane protein 8", "gene_name": "Vamp8", "organism": "Mouse", "refseq_name": "vesicle-associated membrane protein 8", "refseq_ac": [ { "id": "NP_058074", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058074", "type": "external" } ], "gene_names_uniprotkb": "Vamp8", "gene_names_refseq": "Edb; Vamp8; endobrevin", "protein_names_uniprotkb": "Vesicle-associated membrane protein 8; Edb; Endobrevin; VAMP-8", "protein_names_refseq": "VAMP-8; vesicle-associated membrane protein 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:22320); (R-MMU-1236974); (R-MMU-199992); (R-MMU-432720); (R-MMU-432722); (R-MMU-6798695); (R-MMU-8856825); (R-MMU-8856828)", "pathway_count": 8, "publication_count": 12, "publication_id_list": "15363411;19144319;21750661;22118466;27628032;32152506;33454017;33641252;34428180;35174767;9553086;9614193", "class_list": "", "function": "Clearance of intracellular tau protein from neuronal cells via VAMP8-induced secretion., [RefSeq, PubMed]; SNAREs (soluble N-ethylmaleimide-sensitive factor-attachment protein receptors) are essential proteins for intracellular membrane fusion. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four-helix bundle whose assembly releases energy that drives membrane fusion. The core SNARE complex typically consists of four alpha-helical domains, three from target membrane SNAREs (t-SNAREs) and one from a vesicle SNARE (v-SNARE). VAMP8 is a v-SNARE that forms a SNARE complex with the t-SNARE STX11 and SNAP23. This SNARE complex plays a critical role in the regulated exocytosis of cytotoxic granules by natural killer (NK) cells and cytotoxic T-lymphocytes. VAMP8 plays a role in autophagy where it controls organelle-organelle membrane fusion through a VAMP8, SNAP29 and STX17 SNARE complex that mediates the fusion of autophagosome and lysososome membranes (By similarity). VAMP8 is required for dense-granule secretion in platelets (By similarity). Also plays a role in regulated enzyme secretion in pancreatic acinar cells (PubMed:15363411). Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells (By similarity). Involved in the homotypic fusion of early and late endosomes (By similarity). Also participates in the activation of type I interferon antiviral response through a TRIM6-dependent mechanism (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t-SNARE complex. Also required for dense-granule secretion in platelets. Also plays a role in regulated enzyme secretion in pancreatic acinar cells. Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells. Involved in the homotypic fusion of early and late endosomes. Also participates in the activation of type I interferon antiviral response through a TRIM6-dependent mechanism., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CRA3", "ec_number_list": [], "go_molecular_function": "GO:0019869 chloride channel inhibitor activity;GO:0019905 syntaxin binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0042588 zymogen granule;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005769 early endosome;GO:0005829 cytosol", "go_biological_process": "GO:0097352 autophagosome maturation;GO:1902278 positive regulation of pancreatic amylase secretion;GO:0015031 protein transport;GO:0030100 regulation of endocytosis;GO:0051607 defense response to virus", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O70404-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TXX4-1", "uniprot_id": [ { "id": "VGLU1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TXX4", "type": "external" } ], "mass": 61637.0, "length": 560, "protein_name": "Vesicular glutamate transporter 1", "gene_name": "Slc17a7", "organism": "Mouse", "refseq_name": "vesicular glutamate transporter 1", "refseq_ac": [ { "id": "NP_892038", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_892038", "type": "external" } ], "gene_names_uniprotkb": "Slc17a7; Bnpi; Vglut1", "gene_names_refseq": "2900052E22Rik; Slc17a7; Vglut1", "protein_names_uniprotkb": "Vesicular glutamate transporter 1; Brain-specific Na(+)-dependent inorganic phosphate cotransporter; Solute carrier family 17 member 7; VGluT1", "protein_names_refseq": "brain-specific Na(+)-dependent inorganic phosphate cotransporter; solute carrier family 17 member 7; vesicular glutamate transporter 1", "tax_id": 10090, "disease": "sciatic neuropathy (Disease Ontology:DOID:11446); neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330); transient cerebral ischemia (Disease Ontology:DOID:224)", "pathway": " (mmu:72961); (R-MMU-210500); (R-MMU-442660)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;12384506;15103023;15118123;16595674;16942593;17611277;21750661;24153177;25433636;29273736;29642010;33300544;33440152", "class_list": "", "function": "Developing hippocampal neurons transiently coexpressed VGLUT2 and VGLUT1 at distinct synaptic sites with different short-term plasticity; the loss of VGLUT1 reduced the reserve pool of synaptic vesicles [vglut1], [RefSeq, PubMed]; Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, proton, potassium, sodium and phosphate (PubMed:25433636, PubMed:29273736, PubMed:29642010, PubMed:33440152). At the synaptic vesicle membrane, mainly functions as an uniporter which transports preferentially L-glutamate but also phosphate from the cytoplasm into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells (PubMed:15103023, PubMed:15118123, PubMed:25433636, PubMed:29642010). The L-glutamate or phosphate uniporter activity is electrogenic and is driven by the proton electrochemical gradient, mainly by the electrical gradient established by the vacuolar H(+)-ATPase across the synaptic vesicle membrane (PubMed:29642010). In addition, functions as a chloride channel that allows a chloride permeation through the synaptic vesicle membrane that affects the proton electrochemical gradient and promotes synaptic vesicles acidification (PubMed:25433636, PubMed:29273736, PubMed:29642010). Moreover, may function as a K(+)/H(+) antiport allowing to maintain the electrical gradient and to decrease chemical gradient and therefore sustain vesicular glutamate uptake (By similarity). The vesicular K(+)/H(+) antiport activity is electroneutral (By similarity). At the plasma membrane, following exocytosis, functions as a symporter of Na(+) and phosphate from the extracellular space to the cytoplasm allowing synaptic phosphate homeostasis regulation (PubMed:29642010, PubMed:33440152). The symporter activity is driven by an inside negative membrane potential and is electrogenic (PubMed:29642010). Is necessary for synaptic signaling of visual-evoked responses from photoreceptors (PubMed:17611277)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9QMT8", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0005326 neurotransmitter transmembrane transporter activity;GO:0015386 potassium:proton antiporter activity;GO:0005254 chloride channel activity;GO:0008068 extracellularly glutamate-gated chloride channel activity;GO:0005313 L-glutamate transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0045202 synapse;GO:0048786 presynaptic active zone;GO:0098794 postsynapse", "go_biological_process": "GO:0050803 regulation of synapse structure or activity;GO:0060079 excitatory postsynaptic potential;GO:0007268 chemical synaptic transmission;GO:0035249 synaptic transmission, glutamatergic;GO:0006813 potassium ion transport", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q3TXX4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91ZD4-1", "uniprot_id": [ { "id": "VANG2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91ZD4", "type": "external" } ], "mass": 59771.0, "length": 521, "protein_name": "Vang-like protein 2", "gene_name": "Vangl2", "organism": "Mouse", "refseq_name": "vang-like protein 2", "refseq_ac": [ { "id": "NP_277044", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_277044", "type": "external" } ], "gene_names_uniprotkb": "Vangl2; Lpp1; Ltap", "gene_names_refseq": "C530001F03Rik; Lootl; Lpp1; Lp; Ltap; Vang1l2; Vangl2; loop-tail; ska17; ska; stbm; strabismus", "protein_names_uniprotkb": "Vang-like protein 2; Loop-tail protein 1; Loop-tail-associated protein; Van Gogh-like protein 2", "protein_names_refseq": "loop tail associated protein; loop-tail protein 1; van Gogh-like protein 2; vang-like 2 (van gogh, Drosophila); vang-like protein 2", "tax_id": 10090, "disease": "ciliopathy (Disease Ontology:DOID:0060340); neural tube defect (Disease Ontology:DOID:0080074)", "pathway": " (mmu:93840); (R-MMU-9696264); (R-MMU-9696270); (R-MMU-9696273)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "11431695;11440971;11709546;12724779;15195140;15456783;15637299;16495441;16687519;21750661;23029439;34428180", "class_list": "", "function": "Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear (PubMed:16495441)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q923Z8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0016020 membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0060993 kidney morphogenesis;GO:0032956 regulation of actin cytoskeleton organization;GO:0007266 Rho protein signal transduction;GO:0001843 neural tube closure;GO:0009952 anterior/posterior pattern specification", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q91ZD4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BX70-1", "uniprot_id": [ { "id": "VP13C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BX70", "type": "external" } ], "mass": 420089.0, "length": 3748, "protein_name": "Intermembrane lipid transfer protein VPS13C", "gene_name": "Vps13c", "organism": "Mouse", "refseq_name": "intermembrane lipid transfer protein VPS13C", "refseq_ac": [ { "id": "NP_796158", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796158", "type": "external" } ], "gene_names_uniprotkb": "Vps13c; Kiaa3021", "gene_names_refseq": "C230055H22Rik; Vps13c; chorein", "protein_names_uniprotkb": "Intermembrane lipid transfer protein VPS13C; Vacuolar protein sorting-associated protein 13C", "protein_names_refseq": "intermembrane lipid transfer protein VPS13C; vacuolar protein sorting-associated protein 13C", "tax_id": 10090, "disease": "cerebellar ataxia (Disease Ontology:DOID:0050753); choreaacanthocytosis (Disease Ontology:DOID:0050766); Parkinson's disease 23 (Disease Ontology:DOID:0060896); Cohen syndrome (Disease Ontology:DOID:0111590); autosomal recessive spinocerebellar ataxia 4 (Disease Ontology:DOID:0111611); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:320528)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;17188237;17196930;17242355;19131326;19144319;21183079;21750661;24129315;26740625;27329800;31219806;34428180;37507081", "class_list": "", "function": "Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Necessary for proper mitochondrial function and maintenance of mitochondrial transmembrane potential (By similarity). Involved in the regulation of PINK1/PRKN-mediated mitophagy in response to mitochondrial depolarization (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Our findings provide basic information on chorein in vivo and may contribute to taking the first step toward understanding molecular pathogenesis of ChAc., [RefSeq, PubMed]; The present data thus provide evidence for a limited role for changes in VPS13C expression in conferring altered type 2 diabetes risk at this locus, particularly in females, and suggest that C2CD4A, but not C2CD4B, may also be involved., [RefSeq, PubMed]; VPS13C cDNA sequences and brain-specific variants of VPS13C were identified., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3V3W5;Q6ZPE1;Q8BLB1;Q8BQI7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0005764 lysosome;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0045053 protein retention in Golgi apparatus;GO:0006869 lipid transport;GO:0032868 response to insulin;GO:0007005 mitochondrion organization;GO:1905090 negative regulation of type 2 mitophagy", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q8BX70-1", "record_type": "protein", "filter_code": "0000000.1000111.001000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VDF2-1", "uniprot_id": [ { "id": "UHRF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VDF2", "type": "external" } ], "mass": 88304.0, "length": 782, "protein_name": "E3 ubiquitin-protein ligase UHRF1", "gene_name": "Uhrf1", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase UHRF1 isoform A", "refseq_ac": [ { "id": "NP_001104548", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104548", "type": "external" } ], "gene_names_uniprotkb": "Uhrf1; Np95", "gene_names_refseq": "ICBP90; Np95; RNF106; Uhrf1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase UHRF1; 2.3.2.27; Nuclear protein 95; Nuclear zinc finger protein Np95; Ubiquitin-like PHD and RING finger domain-containing protein 1; Ubiquitin-like-containing PHD and RING finger domains protein 1; mUhrf1", "protein_names_refseq": "E3 ubiquitin-protein ligase UHRF1 isoform A; E3 ubiquitin-protein ligase UHRF1; RING-type E3 ubiquitin transferase UHRF1; mUhrf1; nuclear protein 95; nuclear zinc finger protein Np95; ubiquitin-like PHD and RING finger domain-containing protein 1; ubiquitin-like-containing PHD and RING finger domains protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:18140)", "pathway_count": 1, "publication_count": 34, "publication_id_list": "10984098;11161719;12058012;12084726;14993289;15361834;17673620;17994007;18772888;18772891;19056828;19077538;19144319;19798101;20026581;21183079;21268065;21489993;21750661;26065575;28604677;29053958;30392929;31219806;31599954;34428180;34887587;36056023;36210013;38789534;39362877;39627609;8634372;9880673", "class_list": "", "function": "Aberrant cytoplasmic expression of UHRF1 restrains the MHC-I-mediated anti-tumor immune response. Publication Status: Online-Only, [RefSeq, PubMed]; E3 ubiquitin-protein ligase that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification (PubMed:12058012, PubMed:12084726, PubMed:14993289, PubMed:17673620, PubMed:26065575, PubMed:30392929). Plays a key role in DNA methylation inheritance by promoting recruitment of DNMT1 to hemimethylated DNA and ensure faithful propagation of the DNA methylation patterns through DNA replication (PubMed:17673620, PubMed:21268065, PubMed:26065575). Acts both as a histone reader and writer: specifically recognizes and binds (1) hemimethylated DNA at replication forks and (2) histone H3 trimethylated at 'Lys-9' and unmethylated at 'Arg-2' (H3K9me3 and H3R2me0, respectively), thereby activating its E3 ubiquitin-protein ligase activity (PubMed:15361834, PubMed:17994007, PubMed:18772888, PubMed:18772891, PubMed:21489993, PubMed:26065575). UHRF1 then mediates histone H3 'Lys-18' monoubiquitination (H3K18ub), a docking site for DNMT1, leading to DNMT1 recruitment and replication-coupled DNA methylation maintenance (PubMed:26065575, PubMed:29053958, PubMed:30392929). Also mediates histone H3 'Lys-14' and 'Lys-23' ubiquitination (H3K14ub and H3K23ub) at lower level (PubMed:29053958). Histone ubiquitin ligase activity also stimulates the methyltransferase activity of SUV39H1 and/or SUV39H2, promoting accumulation of H3K9me3 histone mark to reinformce heterochromatin state (By similarity). Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication (By similarity). Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications (By similarity). Plays a role in DNA repair by cooperating with UHRF2 to ensure recruitment of FANCD2 to interstrand cross-links (ICLs) leading to FANCD2 activation (By similarity). Also ubiquitinates non-histone proteins, such as histone H3, KIF11 and PML (By similarity). Acts as a critical player of proper spindle architecture by catalyzing the 'Lys-63'-linked ubiquitination of KIF11, thereby controlling KIF11 localization on the spindle (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The E3 ubiquitin-protein ligase UHRF1 promotes adipogenesis and limits fibrosis by suppressing GPNMB-mediated TGF-beta signaling. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U9D7;Q3U9P2;Q3UI74;Q3UIE6;Q3ULF2;Q3ULQ0;Q8C6F1;Q8VIA1;Q9Z1H6", "ec_number_list": [ { "id": "2.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.37", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0003676 nucleic acid binding;GO:0061630 ubiquitin protein ligase activity;GO:0000987 cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016363 nuclear matrix;GO:0000785 chromatin", "go_biological_process": "GO:0050678 regulation of epithelial cell proliferation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "Q8VDF2-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P39447-1", "uniprot_id": [ { "id": "ZO1_MOUSE", "url": "https://www.uniprot.org/uniprot/P39447", "type": "external" } ], "mass": 194742.0, "length": 1745, "protein_name": "Tight junction protein 1", "gene_name": "Tjp1", "organism": "Mouse", "refseq_name": "tight junction protein 1 isoform 1", "refseq_ac": [ { "id": "NP_033412", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033412", "type": "external" } ], "gene_names_uniprotkb": "Tjp1; Zo1", "gene_names_refseq": "Tjp1; ZO1", "protein_names_uniprotkb": "Tight junction protein 1; Tight junction protein ZO-1; Zona occludens protein 1; Zonula occludens protein 1", "protein_names_refseq": "tight junction protein 1 isoform 1; tight junction protein ZO-1; zona occludens protein 1; zonula occludens protein 1", "tax_id": 10090, "disease": "metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); uveitis (Disease Ontology:DOID:13141); cholestasis (Disease Ontology:DOID:13580); peptic esophagitis (Disease Ontology:DOID:13976); brain ischemia (Disease Ontology:DOID:2316); bile duct cancer (Disease Ontology:DOID:4606); gallbladder carcinoma (Disease Ontology:DOID:4948); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677); brain disease (Disease Ontology:DOID:936)", "pathway": " (mmu:21872); (R-MMU-191650); (R-MMU-2028269); (R-MMU-351906)", "pathway_count": 4, "publication_count": 30, "publication_id_list": "10.1101/2023.09.13.557529;10026224;10601346;12424224;15183511;15592455;16188940;16452087;17242355;17947660;18515860;18630941;19131326;20093627;21183079;21431884;21750661;24338688;24588076;24715457;26609154;27015268;29400695;31219806;34418053;34428180;3528172;36210013;37507081;8486731", "class_list": "", "function": "Tjp1, TjpP2, and Tjp3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (By similarity). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting Cdc42bpb to the leading edge of migrating cells (By similarity). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (By similarity). With Tjp2 and TJjp3, participates in the junctional retention and stability of the transcription factor Dbpa, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (PubMed:27015268)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 49, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 9, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "E9QK00", "ec_number_list": [], "go_molecular_function": "GO:0071253 connexin binding;GO:0005516 calmodulin binding;GO:0019904 protein domain specific binding;GO:0044325 transmembrane transporter binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:1903672 positive regulation of sprouting angiogenesis;GO:0150105 protein localization to cell-cell junction;GO:0008284 positive regulation of cell population proliferation;GO:0030335 positive regulation of cell migration;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 3.9, "record_id": "P39447-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q571J5-1", "uniprot_id": [ { "id": "Z354C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q571J5", "type": "external" } ], "mass": 64065.0, "length": 560, "protein_name": "Zinc finger protein 354C", "gene_name": "Znf354c", "organism": "Mouse", "refseq_name": "zinc finger protein 354C", "refseq_ac": [ { "id": "NP_038950", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038950", "type": "external" } ], "gene_names_uniprotkb": "Znf354c; Kiaa4218; Kid3; Zfp354c", "gene_names_refseq": "5330421P20Rik; AJ18; Kid3; Tcf17l2; Zfp354c; Znf354c; mKIAA4218", "protein_names_uniprotkb": "Zinc finger protein 354C; Kidney, ischemia, and developmentally-regulated protein 3", "protein_names_refseq": "kidney, ischemia, and developmentally-regulated protein 3; transcription factor 17-like 2; zinc finger protein 354C", "tax_id": 10090, "disease": "", "pathway": " (mmu:30944); (R-MMU-212436)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10786630;27446912", "class_list": "", "function": "Transcriptional repressor that inhibits endothelial angiogenic sprouting (By similarity). Suppresses osteogenic effects of RUNX2 and may be involved in osteoblastic differentiation (By similarity). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (PubMed:27446912)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UKS9;Q8C365;Q9JLD3", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0031965 nuclear membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:1903671 negative regulation of sprouting angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q571J5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6X786-1", "uniprot_id": [ { "id": "ZPBP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6X786", "type": "external" } ], "mass": 37116.0, "length": 326, "protein_name": "Zona pellucida-binding protein 2", "gene_name": "Zpbp2", "organism": "Mouse", "refseq_name": "zona pellucida-binding protein 2 isoform 3", "refseq_ac": [ { "id": "NP_001159966", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159966", "type": "external" } ], "gene_names_uniprotkb": "Zpbp2", "gene_names_refseq": "1700017D11Rik; 2610022C02Rik; ZPBPL; Zpbp2", "protein_names_uniprotkb": "Zona pellucida-binding protein 2", "protein_names_refseq": "zona pellucida-binding protein 2 isoform 3", "tax_id": 10090, "disease": "childhood-onset asthma (Disease Ontology:DOID:0080815); asthma (Disease Ontology:DOID:2841); lung squamous cell carcinoma (Disease Ontology:DOID:3907); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:69376)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17664285;21750661;29536159;31560728", "class_list": "", "function": "Is implicated in sperm-oocyte interaction during fertilization., [UniProtKB, PubMed]; Study of diurnal expression profiles of ZPBP2/Zpbp2, gasdermin B, and ORMDL3/Ormdl3 in human and mouse tissues revealed that Ormdl3 and Zpbp2 were controlled by the circadian clock in a tissue-specific fashion provided the first evidence that disease-associated genes Zpbp2 and Ormdl3 are regulated by circadian rhythms and the Zpbp2 region influences expression of the core clock gene Nr1d1. Publication Status: Online-Only, [RefSeq, PubMed]; The mouse ortholog of ZPBP2 has a role in controlling airway hypersensitivity in female mice., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A2A4Y0;Q6X785;Q9DA91", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0016020 membrane;GO:0001669 acrosomal vesicle;GO:0044297 cell body;GO:0002199 zona pellucida receptor complex", "go_biological_process": "GO:0007339 binding of sperm to zona pellucida;GO:0006665 sphingolipid metabolic process;GO:0001675 acrosome assembly;GO:0032922 circadian regulation of gene expression;GO:0046466 membrane lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6X786-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RR83-1", "uniprot_id": [ { "id": "YTDC2_MOUSE", "url": "https://www.uniprot.org/uniprot/B2RR83", "type": "external" } ], "mass": 161092.0, "length": 1445, "protein_name": "3'-5' RNA helicase YTHDC2", "gene_name": "Ythdc2", "organism": "Mouse", "refseq_name": "3'-5' RNA helicase YTHDC2", "refseq_ac": [ { "id": "NP_001156485", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156485", "type": "external" } ], "gene_names_uniprotkb": "Ythdc2", "gene_names_refseq": "3010002F02Rik; Ythdc2; mYTHDC2", "protein_names_uniprotkb": "3'-5' RNA helicase YTHDC2; 3.6.4.13; Keen to exit meiosis leaving testes under-populated protein; Ketu; YTH domain-containing protein C2; mYTHDC2", "protein_names_refseq": "3'-5' RNA helicase YTHDC2; YTH domain-containing protein C2; keen to exit meiosis leaving testes under-populated protein; ketu; probable ATP-dependent RNA helicase YTHDC2", "tax_id": 10090, "disease": "", "pathway": " (mmu:240255); (R-MMU-9930044)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;17242355;21183079;21750661;28380054;28809393;29033321;29087293;29360036;31219806;32470506;36001654;38157933;39627609", "class_list": "", "function": "3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells (PubMed:28380054, PubMed:28809393, PubMed:29033321, PubMed:29087293, PubMed:29360036, PubMed:32470506). Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs that plays a role in the efficiency of RNA processing and stability (PubMed:29360036). Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs (PubMed:29033321). Acts by binding and promoting degradation of m6A-containing mRNAs: the 3'-5' RNA helicase activity is required for this process and RNA degradation may be mediated by XRN1 exoribonuclease (PubMed:29033321). Required for both spermatogenesis and oogenesis (PubMed:28809393, PubMed:29033321)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Studies reveal a role for YTHDC2 in modulating the levels of m(6)A-modified germline transcripts to maintain a gene expression program that is conducive for progression through meiosis., [RefSeq, PubMed]; The m[6]A reader YTHDC2 maintains visual function and retinal photoreceptor survival through modulating translation of PPEF2 and PDE6B., [RefSeq, PubMed]; We conclude that when the meiotic chromosomal program is initiated, Meioc is simultaneously induced so as to extend meiotic prophase. Specifically, MEIOC, together with YTHDC2, promotes a meiotic (as opposed to mitotic) cell cycle program via post-transcriptional control of their target transcripts. Publication Status: Online-Only, [RefSeq, PubMed]; YTHDC2 is an N(6)-methyladenosine-binding protein that plays critical roles during spermatogenesis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "2.7.7.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.19", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0070063 RNA polymerase binding;GO:0004386 helicase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0048471 perinuclear region of cytoplasm;GO:0035770 ribonucleoprotein granule", "go_biological_process": "GO:0044829 host-mediated activation of viral genome replication;GO:0034612 response to tumor necrosis factor;GO:0007286 spermatid development;GO:0070555 response to interleukin-1;GO:0048599 oocyte development", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "B2RR83-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R0T2-1", "uniprot_id": [ { "id": "ZN768_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R0T2", "type": "external" } ], "mass": 62711.0, "length": 568, "protein_name": "Zinc finger protein 768", "gene_name": "Zfp768; Znf768", "organism": "Mouse", "refseq_name": "zinc finger protein 768", "refseq_ac": [ { "id": "NP_666314", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666314", "type": "external" } ], "gene_names_uniprotkb": "Zfp768; Znf768; Zfp768", "gene_names_refseq": "Zfp768; Znf768", "protein_names_uniprotkb": "Zinc finger protein 768", "protein_names_refseq": "zinc finger protein 768", "tax_id": 10090, "disease": "", "pathway": " (mmu:233890)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21183079;21750661", "class_list": "", "function": "Binds to mammalian-wide interspersed repeat (MIRs) sequences in euchromatin and promoter regions of genes at the consensus sequence 5'-GCTGTGTG-[N20]-CCTCTCTG-3', consisting of two anchor regions connected by a linker region; the linker region probably does not contribute to the binding specificity (By similarity). Required for cell homeostasis (By similarity). May be involved in transcriptional regulation (Probable)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 27, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005694 chromosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8R0T2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43404-1", "uniprot_id": [ { "id": "ZAP70_MOUSE", "url": "https://www.uniprot.org/uniprot/P43404", "type": "external" } ], "mass": 70112.0, "length": 618, "protein_name": "Tyrosine-protein kinase ZAP-70", "gene_name": "Zap70", "organism": "Mouse", "refseq_name": "tyrosine-protein kinase ZAP-70 isoform TZK", "refseq_ac": [ { "id": "NP_001276541", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276541", "type": "external" } ], "gene_names_uniprotkb": "Zap70; Srk; Zap-70", "gene_names_refseq": "Srk; ZAP-70; Zap70; mrtle; mur", "protein_names_uniprotkb": "Tyrosine-protein kinase ZAP-70; 2.7.10.2; 70 kDa zeta-chain associated protein; Syk-related tyrosine kinase", "protein_names_refseq": "70 kDa zeta-chain associated protein; syk-related tyrosine kinase; tyrosine-protein kinase ZAP-70 isoform TZK; tyrosine-protein kinase ZAP-70", "tax_id": 10090, "disease": "infantile onset multisystem autoimmune disease 2 (Disease Ontology:DOID:0061161); immunodeficiency 48 (Disease Ontology:DOID:0111943); severe combined immunodeficiency (Disease Ontology:DOID:627); rheumatoid arthritis (Disease Ontology:DOID:7148)", "pathway": " (mmu:22637); (R-MMU-202430); (R-MMU-202433); (R-MMU-9013407)", "pathway_count": 4, "publication_count": 19, "publication_id_list": "10037717;10646608;10662792;10952314;11891219;12648457;12705855;14985102;15143214;17028588;17606633;21750661;26903241;30084848;30779550;35820727;7630421;8196616;9208839", "class_list": "", "function": "This gene encodes a member of the protein tyrosine kinase family. The encoded protein is essential for development of T lymphocytes and thymocytes, and functions in the initial step of T lymphocyte receptor-mediated signal transduction. A mutation in this gene causes chronic autoimmune arthritis, similar to rheumatoid arthritis in humans. Mice lacking this gene are deficient in alpha-beta T lymphocytes in the thymus. In humans, mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T lymphocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]., [RefSeq]; Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Also contributes to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the phosphorylated TCR components CD3E and CD247/CD3Z through ITAM motif at the plasma membrane (PubMed:10952314). This recruitment serves to localization to the stimulated TCR and to relieve its autoinhibited conformation. Release of ZAP70 active conformation is further stabilized by phosphorylation mediated by LCK. Subsequently, ZAP70 phosphorylates at least 2 essential adapter proteins: LAT and LCP2. In turn, a large number of signaling molecules are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation. Furthermore, ZAP70 controls cytoskeleton modifications, adhesion and mobility of T-lymphocytes, thus ensuring correct delivery of effectors to the APC. ZAP70 is also required for TCR-CD3Z internalization and degradation through interaction with the E3 ubiquitin-protein ligase CBL and adapter proteins SLA and SLA2. Thus, ZAP70 regulates both T-cell activation switch on and switch off by modulating TCR expression at the T-cell surface. During thymocyte development, ZAP70 promotes survival and cell-cycle progression of developing thymocytes before positive selection (when cells are still CD4/CD8 double negative). Additionally, ZAP70-dependent signaling pathway may also contribute to primary B-cells formation and activation through B-cell receptor (BCR)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P97455;Q80VV2;Q8CHJ3", "ec_number_list": [ { "id": "2.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.13", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" } ], "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0004672 protein kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0016020 membrane", "go_biological_process": "GO:0045061 thymic T cell selection;GO:0006468 protein phosphorylation;GO:0006955 immune response;GO:0018108 peptidyl-tyrosine phosphorylation;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P43404-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3US17-1", "uniprot_id": [ { "id": "ZNF48_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3US17", "type": "external" } ], "mass": 64599.0, "length": 591, "protein_name": "Zinc finger protein 48", "gene_name": "Znf48", "organism": "Mouse", "refseq_name": "zinc finger protein 48", "refseq_ac": [ { "id": "NP_666313", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666313", "type": "external" } ], "gene_names_uniprotkb": "Znf48; Zfp48; Zfp553; Znf553", "gene_names_refseq": "2600009K23Rik; C330013F15Rik; Zfp553; Znf48", "protein_names_uniprotkb": "Zinc finger protein 48; Zinc finger protein 553", "protein_names_refseq": "zinc finger protein 48", "tax_id": 10090, "disease": "", "pathway": " (mmu:233887)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17242355;26423361", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB]; Novel insights to a newly identified pluripotency factor Zfp553 and its role in pluripotency regulation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UFP3;Q8R0V0;Q921H7", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3US17-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JMD0-1", "uniprot_id": [ { "id": "ZN207_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JMD0", "type": "external" } ], "mass": 52793.0, "length": 495, "protein_name": "BUB3-interacting and GLEBS motif-containing protein ZNF207", "gene_name": "Zfp207; Znf207", "organism": "Mouse", "refseq_name": "BUB3-interacting and GLEBS motif-containing protein ZNF207 isoform 1", "refseq_ac": [ { "id": "NP_001123641", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123641", "type": "external" } ], "gene_names_uniprotkb": "Zfp207; Znf207; Bugz; Zep; Zfp207", "gene_names_refseq": "8430401D15Rik; BuGZ; Zep; Zfp207; Znf207", "protein_names_uniprotkb": "BUB3-interacting and GLEBS motif-containing protein ZNF207; 49 kDa zinc finger protein; BuGZ; Zinc finger protein 207", "protein_names_refseq": "49 kDa zinc finger protein; BUB3-interacting and GLEBS motif-containing protein ZNF207 isoform 1; BUB3-interacting and GLEBS motif-containing protein ZNF207", "tax_id": 10090, "disease": "", "pathway": " (mmu:22680)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;21750661;26388440;28528544;29187734;30779550;33300544;34678516;35037361;36852467;40021952;40885482;40997131;9832628", "class_list": "", "function": "Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly. ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks (PubMed:26388440). Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3. Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3. According to another report, the stabilization is independent of the proteasome (By similarity)., [UniProtKB, UniProtKB, PubMed]; ZFP207 sustains pluripotency by coordinating OCT4 stability, alternative splicing and RNA export., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 11, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 11, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 11, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "E9PW12;Q99LA2;Q9Z326", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005819 spindle;GO:0005874 microtubule;GO:0000776 kinetochore", "go_biological_process": "GO:0046785 microtubule polymerization;GO:0008608 attachment of spindle microtubules to kinetochore;GO:0051301 cell division;GO:0090307 mitotic spindle assembly;GO:0050821 protein stabilization", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q9JMD0-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.1100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49282-1", "uniprot_id": [ { "id": "NRAM2_MOUSE", "url": "https://www.uniprot.org/uniprot/P49282", "type": "external" } ], "mass": 62368.0, "length": 568, "protein_name": "Natural resistance-associated macrophage protein 2", "gene_name": "Slc11a2", "organism": "Mouse", "refseq_name": "natural resistance-associated macrophage protein 2 isoform 1", "refseq_ac": [ { "id": "NP_001139633", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139633", "type": "external" } ], "gene_names_uniprotkb": "Slc11a2; Dct1; Dmt1; Nramp2", "gene_names_refseq": "DCT1; DMT1; Nramp2; Slc11a2; mk; van", "protein_names_uniprotkb": "Natural resistance-associated macrophage protein 2; DMT-1; Divalent cation transporter 1; Divalent metal transporter 1; NRAMP 2; Solute carrier family 11 member 2", "protein_names_refseq": "DMT-1; NRAMP 2; divalent cation transporter 1; divalent metal transporter 1; microcytic anemia, viable anaemia; natural resistance-associated macrophage protein 2 isoform 1; natural resistance-associated macrophage protein 2; solute carrier family 11 member 2", "tax_id": 10090, "disease": "restless legs syndrome (Disease Ontology:DOID:0050425); Parkinsonism (Disease Ontology:DOID:0080855); iron deficiency anemia (Disease Ontology:DOID:11758); hypochromic anemia (Disease Ontology:DOID:11759); Parkinson's disease (Disease Ontology:DOID:14330); duodenal ulcer (Disease Ontology:DOID:1724); brain ischemia (Disease Ontology:DOID:2316); anemia (Disease Ontology:DOID:2355); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); pneumonia (Disease Ontology:DOID:552)", "pathway": " (mmu:18174); (R-MMU-425410); (R-MMU-917937)", "pathway_count": 3, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;10361139;11739192;12209011;15849611;16475818;17293870;18776082;19144319;21183079;21750661;25428506;27462458;34428180;38331112;38634270;39062570;7789986;9241278", "class_list": "", "function": "DMT1 ubiquitination by Nedd4 protects against ferroptosis after intracerebral hemorrhage., [RefSeq, PubMed]; DMT1-mediated iron overload accelerates cartilage degeneration in Hemophilic Arthropathy through the mtDNA-cGAS-STING axis., [RefSeq, PubMed]; Ischemic Neuroprotection by Insulin with Down-Regulation of Divalent Metal Transporter 1 (DMT1) Expression and Ferrous Iron-Dependent Cell Death. Publication Status: Online-Only, [RefSeq, PubMed]; Proton-coupled metal ion symporter operating with a proton to metal ion stoichiometry of 1:1 (PubMed:16475818). Selectively transports various divalent metal cations, in decreasing affinity: Cd(2+) > Fe(2+) > Co(2+), Mn(2+) >> Zn(2+), Ni(2+), VO(2+) (By similarity) (PubMed:16475818). Essential for maintenance of iron homeostasis by modulating intestinal absorption of dietary Fe(2+) and TF-associated endosomal Fe(2+) transport in erythroid precursors and other cells (PubMed:11739192). Enables Fe(2+) and Mn(2+) ion entry into mitochondria, and is thus expected to promote mitochondrial heme synthesis, iron-sulfur cluster biogenesis and antioxidant defense (By similarity). Can mediate uncoupled fluxes of either protons or metal ions., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9452, "biomarker_type": "", "glycan_count": 2, "disease_count": 10, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O54903;Q3UFV5;Q8BJL2;Q8BWV3;Q8CFA0;Q8VCU6", "ec_number_list": [], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0046870 cadmium ion binding;GO:0005506 iron ion binding;GO:0008270 zinc ion binding;GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005768 endosome", "go_biological_process": "GO:0034755 iron ion transmembrane transport;GO:0007611 learning or memory;GO:0006879 intracellular iron ion homeostasis;GO:0010042 response to manganese ion;GO:0034599 cellular response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P49282-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U3T8-1", "uniprot_id": [ { "id": "WDR62_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U3T8", "type": "external" } ], "mass": 167283.0, "length": 1523, "protein_name": "WD repeat-containing protein 62", "gene_name": "Wdr62", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Wdr62", "gene_names_refseq": "", "protein_names_uniprotkb": "WD repeat-containing protein 62", "protein_names_refseq": "", "tax_id": 10090, "disease": "primary autosomal recessive microcephaly 2 with or without cortical malformations (Disease Ontology:DOID:0070293); autosomal recessive primary microcephaly (Disease Ontology:DOID:0070296); polymicrogyria (Disease Ontology:DOID:0080918); intellectual disability (Disease Ontology:DOID:1059); microcephaly (Disease Ontology:DOID:10907); high grade glioma (Disease Ontology:DOID:3070)", "pathway": "", "pathway_count": 0, "publication_count": 10, "publication_id_list": "20729831;21183079;21750661;22872234;31219806;31599954;32782141;34428180;36852467;40885482", "class_list": "", "function": "Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (By similarity). Plays a role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 13, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 13, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 13, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 17, "binding_glycan_count": 0, "secondary_ac_list": "Q6PGG0;Q7TQE9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005814 centriole", "go_biological_process": "GO:0021987 cerebral cortex development;GO:0045664 regulation of neuron differentiation;GO:0022008 neurogenesis;GO:0002052 positive regulation of neuroblast proliferation;GO:0097150 neuronal stem cell population maintenance", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q3U3T8-1", "record_type": "protein", "filter_code": "0000000.0000110.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0J4-1", "uniprot_id": [ { "id": "NOS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z0J4", "type": "external" } ], "mass": 160472.0, "length": 1429, "protein_name": "Nitric oxide synthase 1", "gene_name": "Nos1", "organism": "Mouse", "refseq_name": "nitric oxide synthase 1 isoform 2", "refseq_ac": [ { "id": "NP_032738", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032738", "type": "external" } ], "gene_names_uniprotkb": "Nos1", "gene_names_refseq": "2310005C01Rik; N-NOS; NC-NOS; NOS-I; NOS; NO; Nos-1; Nos1; bNOS; nNOS", "protein_names_uniprotkb": "Nitric oxide synthase 1; 1.14.13.39; Constitutive NOS; N-NOS; NC-NOS; NOS type I; Neuronal NOS; Nitric oxide synthase, brain; Peptidyl-cysteine S-nitrosylase NOS1; bNOS; nNOS", "protein_names_refseq": "NOS type I; constitutive NOS; neuronal NOS; neuronal nitric oxide synthase; nitric oxide synthase 1 isoform 2; nitric oxide synthase, brain; peptidyl-cysteine S-nitrosylase NOS1", "tax_id": 10090, "disease": "lissencephaly (Disease Ontology:DOID:0050453); cardiomyopathy (Disease Ontology:DOID:0050700); stroke (Disease Ontology:DOID:0051061); Parkinsonism (Disease Ontology:DOID:0080855); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); Alzheimer's disease (Disease Ontology:DOID:10652); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); nephrotic syndrome (Disease Ontology:DOID:1184); urethral obstruction (Disease Ontology:DOID:12577); hypertrophic pyloric stenosis (Disease Ontology:DOID:12638); alcoholic cardiomyopathy (Disease Ontology:DOID:12935); retinopathy of prematurity (Disease Ontology:DOID:13025); hepatic encephalopathy (Disease Ontology:DOID:13413); Parkinson's disease (Disease Ontology:DOID:14330); major depressive disorder (Disease Ontology:DOID:1470); cystic fibrosis (Disease Ontology:DOID:1485); renovascular hypertension (Disease Ontology:DOID:1591); depressive disorder (Disease Ontology:DOID:1596); epilepsy (Disease Ontology:DOID:1826); impotence (Disease Ontology:DOID:1875); transient cerebral ischemia (Disease Ontology:DOID:224); motor neuron disease (Disease Ontology:DOID:231); brain ischemia (Disease Ontology:DOID:2316); asthma (Disease Ontology:DOID:2841); acute kidney failure (Disease Ontology:DOID:3021); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); temporal lobe epilepsy (Disease Ontology:DOID:3328); schizophrenia (Disease Ontology:DOID:5419); congestive heart failure (Disease Ontology:DOID:6000); end stage renal disease (Disease Ontology:DOID:783); diabetic retinopathy (Disease Ontology:DOID:8947); achalasia (Disease Ontology:DOID:9164); type 2 diabetes mellitus (Disease Ontology:DOID:9352); allergic asthma (Disease Ontology:DOID:9415); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:18125); (R-MMU-1222556); (R-MMU-392154); (R-MMU-5578775)", "pathway_count": 4, "publication_count": 25, "publication_id_list": "10.1101/2023.09.13.557529;10623522;10874031;11086993;15466885;16214135;17258865;17293453;17452640;18096606;18635601;21183079;21750661;22081021;22209711;25025574;26324446;28066266;29577226;29905797;36470319;7545544;7686743;8626668;9208206", "class_list": "", "function": "Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Isoform NNOS Mu may be an effector enzyme for the dystrophin complex., [UniProtKB, PubMed]; Produces nitric oxide (NO) which is a messenger molecule with diverse functions., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 9577, "biomarker_type": "", "glycan_count": 3, "disease_count": 37, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3UR10;Q64208", "ec_number_list": [ { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "7.2.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.10", "type": "external" } ], "go_molecular_function": "GO:0004517 nitric-oxide synthase activity;GO:0046870 cadmium ion binding;GO:0005516 calmodulin binding;GO:0008270 zinc ion binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0044305 calyx of Held;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0018119 peptidyl-cysteine S-nitrosylation;GO:0032496 response to lipopolysaccharide;GO:0043066 negative regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "Q9Z0J4-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q09014-1", "uniprot_id": [ { "id": "NCF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q09014", "type": "external" } ], "mass": 44667.0, "length": 390, "protein_name": "Neutrophil cytosol factor 1", "gene_name": "Ncf1", "organism": "Mouse", "refseq_name": "neutrophil cytosol factor 1 isoform a", "refseq_ac": [ { "id": "NP_001272966", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001272966", "type": "external" } ], "gene_names_uniprotkb": "Ncf1", "gene_names_refseq": "NCF-47K; NOXO2; Ncf-1; Ncf1; p47-phox; p47; p47phox", "protein_names_uniprotkb": "Neutrophil cytosol factor 1; 47 kDa neutrophil oxidase factor; NCF-1; NCF-47K; Neutrophil NADPH oxidase factor 1; p47-phox", "protein_names_refseq": "47 kDa neutrophil oxidase factor; NADPH oxidase subunit (47 kD); NADPH oxidase subunit (47kDa); neutrophil NADPH oxidase factor 1; neutrophil cytosol factor 1 isoform a; neutrophil cytosol factor 1", "tax_id": 10090, "disease": "autosomal recessive chronic granulomatous disease 1 (Disease Ontology:DOID:0070192); Williams-Beuren syndrome (Disease Ontology:DOID:1928); chronic granulomatous disease (Disease Ontology:DOID:3265); rheumatoid arthritis (Disease Ontology:DOID:7148)", "pathway": " (mmu:17969); (R-MMU-1222556); (R-MMU-1236973); (R-MMU-3299685); (R-MMU-4420097); (R-MMU-5668599); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013423)", "pathway_count": 9, "publication_count": 15, "publication_id_list": "16814099;19224205;20173027;20484733;21750661;26021615;27802388;30483268;31219806;34428180;35820727;36210013;39357591;8119734;9490028", "class_list": "", "function": "Knockout of neutrophil cytosolic factor 1 ameliorates neuroinflammation and motor deficit after traumatic brain injury., [RefSeq, PubMed]; Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction. Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane. This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O70144;Q3UE58;Q9JI34", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0043325 phosphatidylinositol-3,4-bisphosphate binding;GO:0035091 phosphatidylinositol binding;GO:0016176 superoxide-generating NADPH oxidase activator activity;GO:0016175 superoxide-generating NAD(P)H oxidase activity", "go_cellular_component": "GO:0043020 NADPH oxidase complex;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0070947 neutrophil-mediated killing of fungus;GO:1903409 reactive oxygen species biosynthetic process;GO:0001878 response to yeast;GO:0006954 inflammatory response;GO:0008283 cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q09014-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91ZV0-1", "uniprot_id": [ { "id": "MIA2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91ZV0", "type": "external" } ], "mass": 156461.0, "length": 1396, "protein_name": "Melanoma inhibitory activity protein 2", "gene_name": "Mia2", "organism": "Mouse", "refseq_name": "melanoma inhibitory activity protein 2 isoform 6 precursor", "refseq_ac": [ { "id": "NP_001355768", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001355768", "type": "external" } ], "gene_names_uniprotkb": "Mia2; Ctage5", "gene_names_refseq": "Ctage5; D12Bwg0579e; Mea6; Mgea6; Mgea; Mia2", "protein_names_uniprotkb": "Melanoma inhibitory activity protein 2; CTAGE family member 5 ER export factor", "protein_names_refseq": "CTAGE family member 5 ER export factor; CTAGE family, member 5; cutaneous T-cell lymphoma-associated antigen 5 homolog; melanoma inhibitory activity 2; melanoma inhibitory activity protein 2 isoform 6 precursor; melanoma inhibitory activity protein 2; meningioma expressed antigen 6 (coiled-coil proline-rich); protein cTAGE-5", "tax_id": 10090, "disease": "", "pathway": " (mmu:338320); (R-MMU-5694530)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "12586826;18630941;19144319;21750661;21807889;24129315;30779550;34428180", "class_list": "", "function": "Mia2 is a novel, hepatic, endoplasmic reticulum-to-Golgi trafficking protein that regulates cholesterol metabolism., [RefSeq, PubMed]; Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. Plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum (By similarity). Thereby, may play a role in cholesterol and triglyceride homeostasis (PubMed:21807889). Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; This gene encodes a protein that is involved in endoplasmic reticulum-to-Golgi trafficking and regulation of cholesterol metabolism. Three major classes of transcripts are generated from this gene- melanoma inhibitory activity 2-specific transcripts, cTAGE family member 5-specific transcripts and transcripts that include exons from both these transcript species. Additionally, alternative splicing in these transcripts results in multiple transcript variants encoding diverse isoforms. A mutation in this gene (couch-potato or cpto) may result in low levels of plasma cholesterol and triglycerides. [provided by RefSeq, Sep 2016]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8CIE3;Q8R311", "ec_number_list": [], "go_molecular_function": "GO:0038024 cargo receptor activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0070971 endoplasmic reticulum exit site;GO:0016020 membrane", "go_biological_process": "GO:0042953 lipoprotein transport;GO:0042632 cholesterol homeostasis;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0009306 protein secretion;GO:0070328 triglyceride homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q91ZV0-1", "record_type": "protein", "filter_code": "0000000.1100101.010000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80Z38-1", "uniprot_id": [ { "id": "SHAN2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80Z38", "type": "external" } ], "mass": 158969.0, "length": 1476, "protein_name": "SH3 and multiple ankyrin repeat domains protein 2", "gene_name": "Shank2", "organism": "Mouse", "refseq_name": "SH3 and multiple ankyrin repeat domains protein 2 isoform a", "refseq_ac": [ { "id": "NP_001074839", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074839", "type": "external" } ], "gene_names_uniprotkb": "Shank2; Cortbp1; Kiaa1022", "gene_names_refseq": "ProSAP1; Shank2; mKIAA1022", "protein_names_uniprotkb": "SH3 and multiple ankyrin repeat domains protein 2; CortBP1; Cortactin-binding protein 1; Shank2", "protein_names_refseq": "SH3 and multiple ankyrin repeat domains protein 2 isoform a; SH3 and multiple ankyrin repeat domains protein 2; SH3/ankyrin domain gene 2; cortBP1; cortactin-binding protein 1", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autistic disorder (Disease Ontology:DOID:12849)", "pathway": " (mmu:210274)", "pathway_count": 1, "publication_count": 24, "publication_id_list": "14679199;15207857;16452087;16452088;17244609;21183079;21423165;21750661;22517741;22645316;22699619;22826440;30059200;32782141;32848054;34678516;35822049;36757814;36852467;38369099;38704506;40021952;40885482;9742101", "class_list": "", "function": "Autism patient-derived SHANK2B[Y29X] mutation affects the development of ALDH1A1 negative dopamine neuron., [RefSeq, PubMed]; Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction (By similarity)., [UniProtKB]; Sex-specific modulation of safety learning in Shank2-deficient mice., [RefSeq, PubMed]; Shank2 negatively regulates CFTR and this may play a significant role in maintaining epithelial homeostasis, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 21, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 21, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 21, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 23, "binding_glycan_count": 0, "secondary_ac_list": "E9QPH7;Q3UTK4;Q5DU07", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0035255 ionotropic glutamate receptor binding;GO:0098919 structural constituent of postsynaptic density", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0030426 growth cone;GO:0032279 asymmetric synapse", "go_biological_process": "GO:0007612 learning;GO:0007613 memory;GO:0008284 positive regulation of cell population proliferation;GO:0008306 associative learning;GO:0008344 adult locomotory behavior", "synthesized_glycan_count": 0, "hit_score": 4.7, "record_id": "Q80Z38-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91VW9-1", "uniprot_id": [ { "id": "ZKSC3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91VW9", "type": "external" } ], "mass": 62642.0, "length": 553, "protein_name": "Zinc finger protein with KRAB and SCAN domains 3", "gene_name": "Zkscan3", "organism": "Mouse", "refseq_name": "zinc finger protein with KRAB and SCAN domains 3 isoform a", "refseq_ac": [ { "id": "NP_001139250", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139250", "type": "external" } ], "gene_names_uniprotkb": "Zkscan3; Skz1; Zfp306; Zfp307; Zfp47", "gene_names_refseq": "2810435N07Rik; Skz1; Zf47; Zfp-47; Zfp306; Zfp307; Zkscan3; mszf35", "protein_names_uniprotkb": "Zinc finger protein with KRAB and SCAN domains 3; SCAN-KRAB-zinc finger protein; Zf47; Zfp-47; Zinc finger protein 306; Zinc finger protein 307; Zinc finger protein 47 homolog", "protein_names_refseq": "SCAN-KRAB-zinc finger gene 1; SCAN-KRAB-zinc finger protein; zinc finger protein 306; zinc finger protein 307; zinc finger protein 47 homolog; zinc finger protein with KRAB and SCAN domains 3 isoform a; zinc finger protein with KRAB and SCAN domains 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:72739); (R-MMU-212436)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "11342224;18940803;21183079;21750661;31219806;35124181;35841832;37144628;37175493;38617741", "class_list": "", "function": "ALKBH5 suppresses autophagic flux via N6-methyladenosine demethylation of ZKSCAN3 mRNA in acute pancreatitis., [RefSeq, PubMed]; Cardiomyocyte ZKSCAN3 regulates remodeling following pressure-overload., [RefSeq, PubMed]; Deacetylation of ZKSCAN3 by SIRT1 induces autophagy and protects SN4741 cells against MPP(+)-induced oxidative stress., [RefSeq, PubMed]; Effect of Lacking ZKSCAN3 on Autophagy, Lysosomal Biogenesis and Senescence. Publication Status: Online-Only, [RefSeq, PubMed]; May be involved in transcriptional regulation., [UniProtKB, UniProtKB]; The kidney-expressed transcription factor ZKSCAN3 is dispensable for autophagy transcriptional regulation and AKI progression in mouse., [RefSeq, PubMed]; Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters (By similarity)., [UniProtKB]; ZKSCAN3 regulates the expression of several genes favoring tumor progression including integrin beta 4 and VEGF, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3V3Z2;Q8CD81;Q9ESY5", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q91VW9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BG51-1", "uniprot_id": [ { "id": "MIRO1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BG51", "type": "external" } ], "mass": 72242.0, "length": 631, "protein_name": "Mitochondrial Rho GTPase 1", "gene_name": "Rhot1", "organism": "Mouse", "refseq_name": "mitochondrial Rho GTPase 1 isoform 2", "refseq_ac": [ { "id": "NP_001156826", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156826", "type": "external" } ], "gene_names_uniprotkb": "Rhot1; Arht1", "gene_names_refseq": "2210403N23Rik; Arht1; C430039G08Rik; Miro1; Rhot1", "protein_names_uniprotkb": "Mitochondrial Rho GTPase 1; 3.6.5.-; MIRO-1; Ras homolog gene family member T1", "protein_names_refseq": "mitochondrial Rho GTPase 1 isoform 2; mitochondrial Rho GTPase 1; ras homolog gene family, member T1", "tax_id": 10090, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330); motor neuron disease (Disease Ontology:DOID:231)", "pathway": " (mmu:59040); (R-MMU-5689880); (R-MMU-9013425)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "21750661;22569362;24431222;28009275;33300544;34428180;37507081", "class_list": "", "function": "Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro 1/2 and Trak2. Publication Status: Online-Only, [RefSeq, PubMed]; Atypical mitochondrial nucleoside-triphosphatase (NTPase) involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution. Promotes mitochondrial fission during high calcium conditions. Can hydrolyze GTP, ATP and UTP (By similarity)., [UniProtKB, UniProtKB]; Miro1 overexpression leads to increased stem cell repair., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJB7;Q3UGU4;Q5SYC3;Q5SYC6;Q8BLW3;Q8BMH1;Q922N0;Q9D2R1;Q9JKB9", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.29", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.6.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.42", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0016887 ATP hydrolysis activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0047497 mitochondrion transport along microtubule;GO:0019725 cellular homeostasis;GO:0007005 mitochondrion organization;GO:0010821 regulation of mitochondrion organization;GO:0097345 mitochondrial outer membrane permeabilization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BG51-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88466-1", "uniprot_id": [ { "id": "ZN106_MOUSE", "url": "https://www.uniprot.org/uniprot/O88466", "type": "external" } ], "mass": 208964.0, "length": 1888, "protein_name": "Zinc finger protein 106", "gene_name": "Zfp106; Znf106", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Zfp106; Znf106; H3a; Sh3bp3; Sirm; Zfp106; Znf474", "gene_names_refseq": "", "protein_names_uniprotkb": "Zinc finger protein 106; H3a minor histocompatibility antigen; Son of insulin receptor mutant; Zfp-106; Zinc finger protein 474", "protein_names_refseq": "", "tax_id": 10090, "disease": "amyotrophic lateral sclerosis (Disease Ontology:DOID:332)", "pathway": "", "pathway_count": 0, "publication_count": 18, "publication_id_list": "15833274;17242355;21183079;21750661;25428506;26604141;27418600;28072389;30084848;31219806;34428180;36210013;36852467;40021952;40885482;40997131;9507006;9846490", "class_list": "", "function": "RNA-binding protein (PubMed:27418600, PubMed:28072389). Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA (PubMed:28072389). Essential for maintenance of peripheral motor neuron and skeletal muscle function (PubMed:26604141, PubMed:27418600, PubMed:28072389). Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4 (PubMed:26604141, PubMed:27418600). Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism (PubMed:26604141)., [UniProtKB, PubMed, PubMed, PubMed]; RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2AKH3;O55185;O88465;O88467;Q792M1;Q792P4;Q8CDZ8;Q8R3I4;Q9ESU3", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005829 cytosol;GO:0016020 membrane;GO:0016607 nuclear speck", "go_biological_process": "GO:0008286 insulin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "O88466-1", "record_type": "protein", "filter_code": "0000000.1000110.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P9S0-1", "uniprot_id": [ { "id": "MTSS2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P9S0", "type": "external" } ], "mass": 76844.0, "length": 715, "protein_name": "Protein MTSS 2", "gene_name": "Mtss2", "organism": "Mouse", "refseq_name": "protein MTSS 2 isoform 2", "refseq_ac": [ { "id": "NP_001297520", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297520", "type": "external" } ], "gene_names_uniprotkb": "Mtss2; Mtss1l", "gene_names_refseq": "ABBA; Mtss1l; Mtss2", "protein_names_uniprotkb": "Protein MTSS 2; MTSS1-like protein", "protein_names_refseq": "MTSS1-like protein; metastasis suppressor 1-like; protein MTSS 2 isoform 2; protein MTSS 2", "tax_id": 10090, "disease": "intellectual developmental disorder with ocular anomalies and distinctive facial features (Disease Ontology:DOID:0081301)", "pathway": " (mmu:244654)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "15345747;16452087;18413296;21183079;21750661;22645316;23060091;30016717;30084848;31232686;34428180;40885482", "class_list": "", "function": "ABBA promotes cell spreading., [RefSeq, PubMed]; Involved in plasma membrane dynamics. Potentiated PDGF-mediated formation of membrane ruffles and lamellipodia in fibroblasts, acting via RAC1 activation. May function in actin bundling., [UniProtKB, UniProtKB]; These results link short-term effects of exercise to activity-dependent expression of Mtss1L, which we propose as a novel effector of activity-dependent rearrangement of synapses. Publication Status: Online-Only, [RefSeq, PubMed]; This study identifies ABBA as a novel regulator of actin and plasma membrane dynamics in radial glial cells., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q8C7B7", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0003785 actin monomer binding;GO:0005096 GTPase activator activity;GO:0005543 phospholipid binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0015629 actin cytoskeleton;GO:0030027 lamellipodium;GO:0032587 ruffle membrane", "go_biological_process": "GO:0007009 plasma membrane organization;GO:0061024 membrane organization;GO:0090630 activation of GTPase activity;GO:0036120 cellular response to platelet-derived growth factor stimulus;GO:0097581 lamellipodium organization", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q6P9S0-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61070-1", "uniprot_id": [ { "id": "EI24_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61070", "type": "external" } ], "mass": 38933.0, "length": 340, "protein_name": "Etoposide-induced protein 2.4", "gene_name": "Ei24", "organism": "Mouse", "refseq_name": "etoposide-induced protein 2.4 isoform 1", "refseq_ac": [ { "id": "NP_001186423", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186423", "type": "external" } ], "gene_names_uniprotkb": "Ei24; Pig8", "gene_names_refseq": "Ei24; PIG8", "protein_names_uniprotkb": "Etoposide-induced protein 2.4; p53-induced gene 8 protein", "protein_names_refseq": "etoposide-induced protein 2.4 isoform 1; etoposide-induced protein 2.4; p53-induced gene 8 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:13663)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10594026;15781622;17208939;17242355;21183079;21750661;29769309;31097220;31332481;33127511;33368642;34428180;8649819", "class_list": "", "function": "Acts as a negative growth regulator via p53-mediated apoptosis pathway. Regulates formation of degradative autolysosomes during autophagy (By similarity)., [UniProtKB, PubMed, PubMed]; Autophagy-related protein EI24 delays the development of pulmonary fibrosis by promoting autophagy., [RefSeq, PubMed]; EI24 alleviates renal interstitial fibrosis through inhibition of epithelial-mesenchymal transition and fibroblast activation., [RefSeq, PubMed]; Etoposide-induced protein 2.4 functions as a regulator of the calcium ATPase and protects pancreatic beta-cell survival, [RefSeq, PubMed]; The Ei24 plays no significant role in colon cancer caused by the substitutional mutation of Apc in mice., [RefSeq, PubMed]; This study shows that the autophagy process is inhibited in EI24-deficient primary pancreatic beta cells. Erratum:[Cell Mol Life Sci. 2020 Jun;77(11):2255-2256. doi: 10.1007/s00018-019-03355-3. PMID: 31754725], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T9X1;Q3TVX9;Q3UGS7", "ec_number_list": [], "go_molecular_function": "GO:0061676 importin-alpha family protein binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0050885 neuromuscular process controlling balance;GO:0016236 macroautophagy;GO:0006914 autophagy;GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage;GO:0030308 negative regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q61070-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ES64-1", "uniprot_id": [ { "id": "USH1C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ES64", "type": "external" } ], "mass": 102285.0, "length": 910, "protein_name": "Harmonin", "gene_name": "Ush1c", "organism": "Mouse", "refseq_name": "harmonin isoform b4", "refseq_ac": [ { "id": "NP_001157205", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157205", "type": "external" } ], "gene_names_uniprotkb": "Ush1c", "gene_names_refseq": "2010016F01Rik; Ush1c; harmonin", "protein_names_uniprotkb": "Harmonin; PDZ domain-containing protein; Usher syndrome type-1C protein homolog", "protein_names_refseq": "PDZ domain-containing protein; Usher syndrome 1C homolog; harmonin isoform b4; usher syndrome type-1C protein homolog", "tax_id": 10090, "disease": "Usher syndrome (Disease Ontology:DOID:0050439); autosomal recessive nonsyndromic deafness 18A (Disease Ontology:DOID:0110473); Usher syndrome type 1 (Disease Ontology:DOID:0110826); Usher syndrome type 1C (Disease Ontology:DOID:0110830)", "pathway": " (mmu:72088)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10973247;12407180;12485990;12588794;15461667;16301216;16301217;19447093;21183079;21750661;24725409;26812017;26812018", "class_list": "", "function": "Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal development and maintenance of cochlear hair cell bundles (PubMed:19447093). As part of the intermicrovillar adhesion complex/IMAC plays a role in brush border differentiation, controlling microvilli organization and length. Probably plays a central regulatory role in the assembly of the complex, recruiting CDHR2, CDHR5 and MYO7B to the microvilli tips (PubMed:24725409, PubMed:26812018)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Forms a complex with cadherin 23 by means of PDZ-domain interactions, [RefSeq, PubMed]; The shaping of the hair bundle relies on a functional unit composed of myosin VIIa, harmonin b and cadherin 23 that is essential to ensure the cohesion of the stereocilia, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91XD1;Q9CVG7;Q9ES65", "ec_number_list": [], "go_molecular_function": "GO:0032029 myosin tail binding;GO:0030507 spectrin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005903 brush border", "go_biological_process": "GO:0042491 inner ear auditory receptor cell differentiation;GO:0030046 parallel actin filament bundle assembly;GO:0042472 inner ear morphogenesis;GO:0050885 neuromuscular process controlling balance;GO:0000086 G2/M transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9ES64-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80X50-1", "uniprot_id": [ { "id": "UBP2L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80X50", "type": "external" } ], "mass": 116799.0, "length": 1107, "protein_name": "Ubiquitin-associated protein 2-like", "gene_name": "Ubap2l", "organism": "Mouse", "refseq_name": "ubiquitin-associated protein 2-like isoform 3", "refseq_ac": [ { "id": "NP_001159455", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159455", "type": "external" } ], "gene_names_uniprotkb": "Ubap2l", "gene_names_refseq": "3110083O19Rik; 4932431F02Rik; A430103N23Rik; Nice-4; Ubap2l; mKIAA0144", "protein_names_uniprotkb": "Ubiquitin-associated protein 2-like; RNA polymerase II degradation factor Ubap2l", "protein_names_refseq": "Nice-4 protein homolog; RNA polymerase II degradation factor Ubap2l; ubiquitin-associated protein 2-like isoform 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:74383)", "pathway_count": 1, "publication_count": 27, "publication_id_list": "10.1101/2023.09.13.557529;15592455;17242355;18250455;19131326;19144319;21183079;21750661;22517741;22645316;23443134;25185265;25605945;27669760;29237092;30059200;31219806;31616917;32782141;32848054;34428180;34678516;34887587;35820727;35977029;36852467;40997131", "class_list": "", "function": "Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (By similarity). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs) (PubMed:25185265). Is a regulator of stress granule assembly, required for their efficient formation (PubMed:35977029). Required for proper brain development and neocortex lamination (PubMed:35977029)., [UniProtKB, PubMed, UniProtKB, PubMed]; Two different BMI1-containing PcG complexes regulate hematopoietic stem cell activity, which are distinguishable by the presence of UBAP2L., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 49, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 49, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 49, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 52, "binding_glycan_count": 0, "secondary_ac_list": "Q8BIT6;Q8BIW4;Q8BJ01;Q8CIG7;Q8K102;Q9CRT6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005694 chromosome;GO:0010494 cytoplasmic stress granule;GO:0031519 PcG protein complex", "go_biological_process": "GO:0007339 binding of sperm to zona pellucida;GO:0034063 stress granule assembly;GO:0061484 hematopoietic stem cell homeostasis;GO:0062029 positive regulation of stress granule assembly", "synthesized_glycan_count": 0, "hit_score": 8.2, "record_id": "Q80X50-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60605-1", "uniprot_id": [ { "id": "MYL6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60605", "type": "external" } ], "mass": 16930.0, "length": 151, "protein_name": "Myosin light polypeptide 6", "gene_name": "Myl6", "organism": "Mouse", "refseq_name": "myosin light polypeptide 6 isoform MLC3nm", "refseq_ac": [ { "id": "NP_001304147", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001304147", "type": "external" } ], "gene_names_uniprotkb": "Myl6; Myln", "gene_names_refseq": "ESMLC; LC17-GI; LC17; MLC-3; MLC1SM; Myl6; Myln", "protein_names_uniprotkb": "Myosin light polypeptide 6; 17 kDa myosin light chain; LC17; MLC-3; Myosin light chain 3; Myosin light chain A3; Myosin light chain alkali 3; Smooth muscle and nonmuscle myosin light chain alkali 6", "protein_names_refseq": "17 kDa myosin light chain; myosin light chain A3; myosin light chain alkali 3; myosin light chain, alkali, nonmuscle; myosin light polypeptide 6 isoform MLC3nm; myosin light polypeptide 6; smooth muscle and nonmuscle myosin light chain alkali 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:17904); (R-MMU-445355); (R-MMU-5627123)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "19144319;21183079;21540332;21750661;22645316;23806337;24788674;25428506;25605924;31219806;34203471;34428180;34887587;36210013;37453647;7804326", "class_list": "", "function": "Regulatory light chain of myosin. Does not bind calcium., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0008307 structural constituent of muscle;GO:0003774 cytoskeletal motor activity;GO:0000146 microfilament motor activity", "go_cellular_component": "GO:0005903 brush border;GO:0016459 myosin complex;GO:0016460 myosin II complex;GO:0016461 unconventional myosin complex", "go_biological_process": "GO:0006936 muscle contraction;GO:0030049 muscle filament sliding;GO:0007519 skeletal muscle tissue development", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q60605-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54265-1", "uniprot_id": [ { "id": "DMPK_MOUSE", "url": "https://www.uniprot.org/uniprot/P54265", "type": "external" } ], "mass": 69602.0, "length": 631, "protein_name": "Myotonin-protein kinase", "gene_name": "Dmpk", "organism": "Mouse", "refseq_name": "myotonin-protein kinase isoform 3", "refseq_ac": [ { "id": "NP_001177420", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001177420", "type": "external" } ], "gene_names_uniprotkb": "Dmpk; Dm15; Mdpk", "gene_names_refseq": "DMK; DM; Dm15; Dmpk; MDPK; MT-PK", "protein_names_uniprotkb": "Myotonin-protein kinase; 2.7.11.1; DM-kinase; DMK; DMPK; MDPK; MT-PK; Myotonic dystrophy protein kinase", "protein_names_refseq": "DM-kinase; dystrophia myotonica kinase, B15; myotonic dystrophy protein kinase; myotonin-protein kinase isoform 3; myotonin-protein kinase", "tax_id": 10090, "disease": "myotonic dystrophy type 1 (Disease Ontology:DOID:11722)", "pathway": " (mmu:13400); (R-MMU-5578775)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "10699184;10936001;12612014;1302022;15557165;15598648;15684391;18439618;18729234;21295081;21750661;21949239;22190319;25063871;34428180;35054778;8401505;8499920;8673132;9294109", "class_list": "", "function": "Cytosolic DMPK participates in remodeling of the actomyosin cytoskeleton in developing skeletal muscle cells., [RefSeq, PubMed]; DM1 Transgenic Mice Exhibit Abnormal Neurotransmitter Homeostasis and Synaptic Plasticity in Association with RNA Foci and Mis-Splicing in the Hippocampus. Publication Status: Online-Only, [RefSeq, PubMed]; Data show that during cardiac myocyte maturation, DMPK migrates from perinuclear to cellular membrane localization. Manipulating DMPK levels in cultured cardiac and skeletal myocytes has revealed a key role for DMPK in myocyte differentiation., [RefSeq, PubMed]; Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; The data of this study demonstrated that DMPK knockout mice present altered beta-agonist-induced responses and suggest that this is due, at least in part, to a reduced density of beta(1)-adrenergic receptors in cardiac plasma membranes., [RefSeq, PubMed]; The protein encoded by this gene is a serine/threonine protein kinase that contains coiled-coil and C-terminal membrane association domains. In the embryonic mouse, it is found in cardiac and skeletal myocytes where it appears to play a role in myogenesis. In adults, the transcript is localized to several tissues including brain, heart, and skeletal and smooth muscle, and a function in cytoskeletal remodeling has been described. Transcripts with expanded CUG repeats in the 3' untranslated region mediate alternative splicing of several genes and sequester RNA binding proteins and RNA transcripts that contain CAG repeats, resulting in myotonic dystrophy, an autosomal dominant neuromuscular disorder. Alternative splicing results in multiple protein coding and non-coding transcript variants. [provided by RefSeq, Oct 2014]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0017020 myosin phosphatase regulator activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0010657 muscle cell apoptotic process;GO:0010830 regulation of myotube differentiation;GO:0014722 regulation of skeletal muscle contraction by calcium ion signaling;GO:0014853 regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction;GO:0006468 protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P54265-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CR48-1", "uniprot_id": [ { "id": "DRAM2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CR48", "type": "external" } ], "mass": 30228.0, "length": 267, "protein_name": "DNA damage-regulated autophagy modulator protein 2", "gene_name": "Dram2", "organism": "Mouse", "refseq_name": "DNA damage-regulated autophagy modulator protein 2 isoform 2", "refseq_ac": [ { "id": "NP_001273915", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273915", "type": "external" } ], "gene_names_uniprotkb": "Dram2; Tmem77", "gene_names_refseq": "2010305N14Rik; 2610318G18Rik; Dram2; Tmem77", "protein_names_uniprotkb": "DNA damage-regulated autophagy modulator protein 2; Transmembrane protein 77", "protein_names_refseq": "DNA damage-regulated autophagy modulator protein 2 isoform 2; DNA damage-regulated autophagy modulator protein 2; VDNA-damage regulated autophagy modulator 2; transmembrane protein 77", "tax_id": 10090, "disease": "cone-rod dystrophy 21 (Disease Ontology:DOID:0081447)", "pathway": " (mmu:67171)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;25983245", "class_list": "", "function": "Plays a role in the initiation of autophagy. In the retina, might be involved in the process of photoreceptor cells renewal and recycling to preserve visual function. Induces apoptotic cell death when coexpressed with DRAM1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D520", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0008283 cell population proliferation;GO:0010506 regulation of autophagy;GO:0006915 apoptotic process;GO:0007601 visual perception;GO:0045494 photoreceptor cell maintenance", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CR48-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97427-1", "uniprot_id": [ { "id": "DPYL1_MOUSE", "url": "https://www.uniprot.org/uniprot/P97427", "type": "external" } ], "mass": 62168.0, "length": 572, "protein_name": "Dihydropyrimidinase-related protein 1", "gene_name": "Crmp1", "organism": "Mouse", "refseq_name": "dihydropyrimidinase-related protein 1 isoform 2", "refseq_ac": [ { "id": "NP_031791", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031791", "type": "external" } ], "gene_names_uniprotkb": "Crmp1; Dpysl1; Ulip3", "gene_names_refseq": "CRMP-1; Crmp1; DRP-1; Dpysl1; ULIP-3; Ulip3", "protein_names_uniprotkb": "Dihydropyrimidinase-related protein 1; CRMP-1; Collapsin response mediator protein 1; DRP-1; Inactive dihydropyrimidinase; ULIP-3; Unc-33-like phosphoprotein 3", "protein_names_refseq": "dihydropyrimidinase-related protein 1 isoform 2; dihydropyrimidinase-related protein 1; inactive dihydropyrimidinase; unc-33-like phosphoprotein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:12933); (R-MMU-399956)", "pathway_count": 2, "publication_count": 25, "publication_id_list": "10.1101/2023.09.13.557529;10956643;14685275;15345747;16800626;17121542;17344389;18034455;18250455;20506281;21183079;21750661;22279220;22645316;25358863;26740625;33300544;33449368;34428180;38176125;38430221;38480688;40684658;9107681;9652388", "class_list": "", "function": "CRMP-1 may be involved in proper neurite outgrowth in the adult hippocampus. Loss of CRMP-1 may affect LTP maintenance and spatial learning and memory., [RefSeq, PubMed]; Fat mass and obesity associated protein inhibits neuronal ferroptosis via the FYN/Drp1 axis and alleviate cerebral ischemia/reperfusion injury., [RefSeq, PubMed]; Imbalance of synaptic and extrasynaptic NMDA receptors induced by the deletion of CRMP1 accelerates age-related cognitive decline in mice., [RefSeq, PubMed]; Mice lacking Crmp1 showed a decrease in the number of granule cells migrating out of explants of developing cerebellum., [RefSeq, PubMed]; NME3 is a gatekeeper for DRP1-dependent mitophagy in hypoxia. Publication Status: Online-Only, [RefSeq, PubMed]; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (PubMed:14685275, PubMed:25358863). Plays a role in axon guidance (PubMed:14685275). During the axon guidance process, acts downstream of SEMA3A to promote FLNA dissociation from F-actin which results in the rearrangement of the actin cytoskeleton and the collapse of the growth cone (PubMed:25358863). Involved in invasive growth and cell migration (By similarity). May participate in cytokinesis (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; This gene encodes a protein that is part of the collapsin response mediator protein family. The family is comprised of five, homologous cytosolic phosphoproteins that are expressed in developing and adult nervous tissue and mediate signaling to transduce responses to extracellular cues. This protein is a Semaphorin 3A signaling molecule that regulates collapse of the growth cone. The growth cone mediates axonal pathfinding in neurons. This protein is reported to represent a new class of microtubule-associated proteins. In humans this protein is reported to inhibit cancer cell invasion. In mouse deficiency of this gene may be associated with impaired spatial memory performance. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "O08554;O35097", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0051219 phosphoprotein binding;GO:0031005 filamin binding;GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005813 centrosome;GO:0005819 spindle;GO:0005829 cytosol;GO:0015629 actin cytoskeleton;GO:0030425 dendrite", "go_biological_process": "GO:0071526 semaphorin-plexin signaling pathway;GO:0010977 negative regulation of neuron projection development;GO:0150052 regulation of postsynapse assembly", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "P97427-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TLP5-1", "uniprot_id": [ { "id": "ECHD2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TLP5", "type": "external" } ], "mass": 31852.0, "length": 296, "protein_name": "Enoyl-CoA hydratase domain-containing protein 2, mitochondrial", "gene_name": "Echdc2", "organism": "Mouse", "refseq_name": "enoyl-CoA hydratase domain-containing protein 2, mitochondrial isoform 2", "refseq_ac": [ { "id": "NP_001241683", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001241683", "type": "external" } ], "gene_names_uniprotkb": "Echdc2; D4Ertd765e", "gene_names_refseq": "1300017C12Rik; 2610009M20Rik; D4Ertd765e; Echdc2", "protein_names_uniprotkb": "Enoyl-CoA hydratase domain-containing protein 2, mitochondrial", "protein_names_refseq": "enoyl-CoA hydratase domain-containing protein 2, mitochondrial isoform 2; enoyl-CoA hydratase domain-containing protein 2, mitochondrial", "tax_id": 10090, "disease": "3-methylglutaconic aciduria type 1 (Disease Ontology:DOID:0110002)", "pathway": " (mmu:52430)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;23576753;23806337;25428506;35820727", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2APS6;Q3TKJ7;Q3TV08;Q3U553;Q8R3K4;Q9DBD3", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0004300 enoyl-CoA hydratase activity;GO:0016829 lyase activity;GO:0003824 catalytic activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006635 fatty acid beta-oxidation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3TLP5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TT37-1", "uniprot_id": [ { "id": "ELP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TT37", "type": "external" } ], "mass": 149584.0, "length": 1333, "protein_name": "Elongator complex protein 1", "gene_name": "Elp1", "organism": "Mouse", "refseq_name": "elongator complex protein 1", "refseq_ac": [ { "id": "NP_080355", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080355", "type": "external" } ], "gene_names_uniprotkb": "Elp1; Ikap; Ikbkap", "gene_names_refseq": "3110040G09Rik; 6030413P05; Elp1; IKAP; Ikbkap", "protein_names_uniprotkb": "Elongator complex protein 1; ELP1; IKK complex-associated protein; IkappaB kinase complex-associated protein", "protein_names_refseq": "IKK complex-associated protein; IKK-complex-associated protein IKAP; elongator complex protein 1; ikappaB kinase complex-associated protein; inhibitor of kappa light polypeptide enhancer in B cells, kinase complex-associated protein", "tax_id": 10090, "disease": "hemophagocytic lymphohistiocytosis (Disease Ontology:DOID:0050120); medulloblastoma (Disease Ontology:DOID:0050902); scoliosis (Disease Ontology:DOID:0060249); familial dysautonomia (Disease Ontology:DOID:11589); asthma (Disease Ontology:DOID:2841); kyphosis (Disease Ontology:DOID:4667)", "pathway": " (mmu:230233)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "11722848;11747609;17644305;19185337;22645316;22854966;23717213;28135057;31219806;31827135;33300544;34428180;37507081;39627609", "class_list": "", "function": "Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:23717213). Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (PubMed:22854966). ELP1 binds to tRNA, mediating interaction of the elongator complex with tRNA (By similarity). May act as a scaffold protein that assembles active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK) (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; Description of a humanized IKBKAP transgenic mouse that models a tissue-specific human splicing defect, [RefSeq, PubMed]; Mutations in the human I-kappaB kinase-associated protein (IKBKAP) gene are responsible for familial dysautonomia (FD).no animal model of FD currently exists, cloning of the mouse Ikbkap gene is an important step toward creating a mouse model for FD, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UHY6;Q7TQH1;Q8C6B3;Q8CBI3;Q8CH82;Q8VHU5;Q8VHV9;Q9CT81", "ec_number_list": [], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0000049 tRNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0033588 elongator holoenzyme complex", "go_biological_process": "GO:0002098 tRNA wobble uridine modification;GO:0007252 I-kappaB phosphorylation;GO:0002926 tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q7TT37-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BFR5-1", "uniprot_id": [ { "id": "EFTU_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BFR5", "type": "external" } ], "mass": 49508.0, "length": 452, "protein_name": "Elongation factor Tu, mitochondrial", "gene_name": "Tufm", "organism": "Mouse", "refseq_name": "elongation factor Tu, mitochondrial isoform 2", "refseq_ac": [ { "id": "NP_001157185", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157185", "type": "external" } ], "gene_names_uniprotkb": "Tufm", "gene_names_refseq": "2300002G02Rik; EF-TuMT; EFTU; Tufm", "protein_names_uniprotkb": "Elongation factor Tu, mitochondrial; 3.6.5.3", "protein_names_refseq": "elongation factor Tu, mitochondrial isoform 2; elongation factor Tu, mitochondrial", "tax_id": 10090, "disease": "chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515); combined oxidative phosphorylation deficiency 4 (Disease Ontology:DOID:0111494)", "pathway": " (mmu:233870)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;22749352;23576753;23806337;25428506;26495903;30084848;33300544;33398033;33774866;34428180;35820727;36288343;36470869;37453647;37507081;39627609;39927985;40684658", "class_list": "", "function": "Activation of mitochondrial TUFM ameliorates metabolic dysregulation through coordinating autophagy induction. Publication Status: Online-Only, [RefSeq, PubMed]; By recruiting Atg5-Atg12 and NLRX1, TUFM serves as a nodal checkpoint of the RIG-I-MAVS axis. It acts similarly to NLRX1 by inhibiting RigI-like-receptor-induced IFN-I but promoting autophagy., [RefSeq, PubMed]; FUNDC1 protects against doxorubicin-induced cardiomyocyte PANoptosis through stabilizing mtDNA via interaction with TUFM. Publication Status: Online-Only, [RefSeq, PubMed]; GTP hydrolase that promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Participates in mitochondrial translation (By similarity). Also plays a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIGI-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; TUFM is involved in Alzheimer's disease-like pathologies that are associated with ROS., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q497E7;Q6P919", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0003746 translation elongation factor activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0042645 mitochondrial nucleoid;GO:0043209 myelin sheath;GO:0045202 synapse", "go_biological_process": "GO:0070125 mitochondrial translational elongation;GO:0006414 translational elongation;GO:1902775 mitochondrial large ribosomal subunit assembly;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q8BFR5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99MS7-1", "uniprot_id": [ { "id": "EH1L1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99MS7", "type": "external" } ], "mass": 184834.0, "length": 1716, "protein_name": "EH domain-binding protein 1-like protein 1", "gene_name": "Ehbp1l1", "organism": "Mouse", "refseq_name": "EH domain-binding protein 1-like protein 1 isoform B", "refseq_ac": [ { "id": "NP_444482", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444482", "type": "external" } ], "gene_names_uniprotkb": "Ehbp1l1", "gene_names_refseq": "Ehbp1l1; G430002G23Rik", "protein_names_uniprotkb": "EH domain-binding protein 1-like protein 1; Tangerin", "protein_names_refseq": "EH domain-binding protein 1-like protein 1 isoform B; EH domain-binding protein 1-like protein 1; tangerin", "tax_id": 10090, "disease": "", "pathway": " (mmu:114601)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "19144319;21183079;21750661;26495903;26833786;28528544;33725478;36288343;37042948", "class_list": "", "function": "Data demonstrate that EHBP1L1 links Rab8 and the Bin1-dynamin complex, which generates membrane curvature and excises the vesicle at the endocytic recycling compartment for apical transport., [RefSeq, PubMed]; EHBP1L1, an apicobasal polarity regulator, is critical for nuclear polarization during enucleation of erythroblasts. Erratum:[Blood Adv. 2024 Mar 12;8(5):1151. doi: 10.1182/bloodadvances.2023011838. PMID: 38421726], [RefSeq, PubMed]; May act as Rab effector protein and play a role in vesicle trafficking (By similarity). Involved in apical-directed transport in polarized epithelial cells; the functions seems to implicate Rab8, BIN1 and possibly DNM1 (PubMed:26833786)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3V443;Q8C2W6;Q99J97;Q99MS5;Q99MS6", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0055037 recycling endosome;GO:0005768 endosome", "go_biological_process": "GO:0000902 cell morphogenesis;GO:0030036 actin cytoskeleton organization;GO:0030218 erythrocyte differentiation;GO:0032880 regulation of protein localization;GO:0009791 post-embryonic development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q99MS7-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CZR8-1", "uniprot_id": [ { "id": "EFTS_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CZR8", "type": "external" } ], "mass": 35334.0, "length": 324, "protein_name": "Elongation factor Ts, mitochondrial", "gene_name": "Tsfm", "organism": "Mouse", "refseq_name": "elongation factor Ts, mitochondrial precursor", "refseq_ac": [ { "id": "NP_079813", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079813", "type": "external" } ], "gene_names_uniprotkb": "Tsfm", "gene_names_refseq": "2310050B20Rik; 9430024O13Rik; EF-TS; EF-Tsmt; Tsfm", "protein_names_uniprotkb": "Elongation factor Ts, mitochondrial; EF-TsMt; EF-Ts", "protein_names_refseq": "elongation factor Ts, mitochondrial precursor; elongation factor Ts, mitochondrial", "tax_id": 10090, "disease": "combined oxidative phosphorylation deficiency 3 (Disease Ontology:DOID:0111486)", "pathway": " (mmu:66399)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;23806337;31219806;37507081", "class_list": "", "function": "Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Participates in mitochondrial translation., [UniProtKB, UniProtKB, UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TFF5", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0003746 translation elongation factor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0070125 mitochondrial translational elongation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9CZR8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQP2-1", "uniprot_id": [ { "id": "EHD4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EQP2", "type": "external" } ], "mass": 61481.0, "length": 541, "protein_name": "EH domain-containing protein 4", "gene_name": "Ehd4", "organism": "Mouse", "refseq_name": "EH domain-containing protein 4 isoform 1", "refseq_ac": [ { "id": "NP_598599", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598599", "type": "external" } ], "gene_names_uniprotkb": "Ehd4; Past2", "gene_names_refseq": "2210022F10Rik; Ehd4; Past2", "protein_names_uniprotkb": "EH domain-containing protein 4; PAST homolog 2; mPAST2", "protein_names_refseq": "EH domain containing protein MPAST2; EH domain-containing protein 4 isoform 1; EH domain-containing protein 4; PAST homolog 2; mPAST2", "tax_id": 10090, "disease": "", "pathway": " (mmu:98878)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "15930129;19487694;20213691;21177873;21183079;26495903;26740625;28943089;30084848;33972531;34428180;36288343;37507081;37828378;39627609", "class_list": "", "function": "ATP- and membrane-binding protein that probably controls membrane reorganization/tubulation upon ATP hydrolysis. Plays a role in early endosomal transport (PubMed:15930129). During sprouting angiogenesis, in complex with PACSIN2 and MICALL1, forms recycling endosome-like tubular structure at asymmetric adherens junctions to control CDH5 trafficking (PubMed:33972531)., [UniProtKB, PubMed, PubMed]; EHD1, EHD2, and EHD4 are recruited to caveolae. Recruitment of the other EHDs increases markedly when EHD2, which has been previously detected at caveolae, is absent. Construction of knockout cell lines lacking EHDs 1, 2, and 4 confirms this apparent functional redundancy., [RefSeq, PubMed]; EHD4 is a novel CDH23-interacting protein that could regulate CDH23 trafficking/localization in a calcium-sensitive manner., [RefSeq, PubMed]; Results suggest a role for EHD4 in the proper development of postmitotic and postmeiotic germ cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0030674 protein-macromolecule adaptor activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005912 adherens junction", "go_biological_process": "GO:0006897 endocytosis;GO:0030100 regulation of endocytosis;GO:0051260 protein homooligomerization;GO:0072659 protein localization to plasma membrane;GO:0071363 cellular response to growth factor stimulus", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9EQP2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QXY6-1", "uniprot_id": [ { "id": "EHD3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QXY6", "type": "external" } ], "mass": 60821.0, "length": 535, "protein_name": "EH domain-containing protein 3", "gene_name": "Ehd3", "organism": "Mouse", "refseq_name": "EH domain-containing protein 3", "refseq_ac": [ { "id": "NP_065603", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065603", "type": "external" } ], "gene_names_uniprotkb": "Ehd3; Ehd2", "gene_names_refseq": "Ehd2; Ehd3", "protein_names_uniprotkb": "EH domain-containing protein 3", "protein_names_refseq": "EH domain-containing protein 3; EH-domain containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:57440); (R-MMU-983231)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "12121420;15930129;17251388;17507647;20484733;20489164;21183079;21408024;22974368;24373286;24759929;25605945;25686250;25825486;26896729;30084848;33300544;33964295;34428180", "class_list": "", "function": "ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes tubulation of endocytic membranes (By similarity). Binding to phosphatidic acid induces its membrane tubulation activity (PubMed:26896729). Plays a role in endocytic transport. Involved in early endosome to recycling endosome compartment (ERC), retrograde early endosome to Golgi, and endosome to plasma membrane (rapid recycling) protein transport. Involved in the regulation of Golgi maintenance and morphology (By similarity). Involved in the recycling of internalized D1 dopamine receptor (By similarity). Plays a role in cardiac protein trafficking probably implicating ANK2. Involved in the ventricular membrane targeting of SLC8A1 and CACNA1C and probably the atrial membrane localization of CACNA1GG and CACNA1H implicated in the regulation of atrial myocyte excitability and cardiac conduction (PubMed:20489164, PubMed:24759929, PubMed:25825486). In conjunction with EHD4 may be involved in endocytic trafficking of KDR/VEGFR2 implicated in control of glomerular function (PubMed:21408024). Involved in the rapid recycling of integrin beta-3 implicated in cell adhesion maintenance (By similarity). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing. Plays a role in the formation of the ciliary vesicle, an early step in cilium biogenesis; possibly sharing redundant functions with Ehd1 (PubMed:25686250)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; EHD3 positively regulated by NR5A1 participates in testosterone synthesis via endocytosis., [RefSeq, PubMed]; EHD3: a protein that resides in recycling tubular and vesicular membrane structures and interacts with EHD1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K590", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0030674 protein-macromolecule adaptor activity;GO:0005509 calcium ion binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005929 cilium", "go_biological_process": "GO:0006897 endocytosis;GO:0015031 protein transport;GO:0051260 protein homooligomerization;GO:0072659 protein localization to plasma membrane;GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q9QXY6-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WVK4-1", "uniprot_id": [ { "id": "EHD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WVK4", "type": "external" } ], "mass": 60603.0, "length": 534, "protein_name": "EH domain-containing protein 1", "gene_name": "Ehd1", "organism": "Mouse", "refseq_name": "EH domain-containing protein 1", "refseq_ac": [ { "id": "NP_034249", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034249", "type": "external" } ], "gene_names_uniprotkb": "Ehd1; Past1", "gene_names_refseq": "Ehd1; Past1; RME-1", "protein_names_uniprotkb": "EH domain-containing protein 1; PAST homolog 1; mPAST1", "protein_names_refseq": "EH domain-containing protein 1; PAST homolog 1; mPAST1", "tax_id": 10090, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:13660); (R-MMU-983231)", "pathway_count": 2, "publication_count": 22, "publication_id_list": "10395801;12121420;15247266;15592455;15930129;20159556;20173027;21177873;21183079;23572513;24373286;26740625;29187734;31219806;34203471;34428180;34887587;36288343;37453647;37474760;37507081;37828378", "class_list": "", "function": "ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes vesiculation of endocytic membranes (By similarity). Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes (PubMed:15930129, PubMed:20159556). Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth (By similarity). Plays a role in myoblast fusion (PubMed:21177873). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing (PubMed:24373286). Plays a role in the formation of the ciliary vesicle (CV), an early step in cilium biogenesis. Proposed to be required for the fusion of distal appendage vesicles (DAVs) to form the CV by recruiting SNARE complex component SNAP29. Is required for recruitment of transition zone proteins CEP290, RPGRIP1L, TMEM67 and B9D2, and of IFT20 following DAV reorganization before Rab8-dependent ciliary membrane extension. Required for the loss of CCP110 form the mother centriole essential for the maturation of the basal body during ciliogenesis (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; EHD1 and EHBP1, but not EHD2, are required for perinuclear localization of GLUT4 and reveal that loss of EHBP1 disrupts insulin-regulated GLUT4 recycling in cultured adipocytes., [RefSeq, PubMed]; EHD1-dependent traffic of IGF-1 receptor to the cell surface is essential for Ewing sarcoma tumorigenesis and metastasis. Publication Status: Online-Only, [RefSeq, PubMed]; EHD3: a protein that resides in recycling tubular and vesicular membrane structures and interacts with EHD1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome;GO:0005811 lipid droplet", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006897 endocytosis;GO:0010976 positive regulation of neuron projection development;GO:0031175 neuron projection development;GO:0051260 protein homooligomerization", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q9WVK4-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z148-1", "uniprot_id": [ { "id": "EHMT2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z148", "type": "external" } ], "mass": 138039.0, "length": 1263, "protein_name": "Histone-lysine N-methyltransferase EHMT2", "gene_name": "Ehmt2", "organism": "Mouse", "refseq_name": "histone-lysine N-methyltransferase EHMT2 isoform c", "refseq_ac": [ { "id": "NP_001273502", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273502", "type": "external" } ], "gene_names_uniprotkb": "Ehmt2; Bat8; G9a; Ng36", "gene_names_refseq": "Bat8; D17Ertd710e; Ehmt2; G9a; KMT1C; NG36", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase EHMT2; 2.1.1.-; 2.1.1.367; Euchromatic histone-lysine N-methyltransferase 2; H3-K9-HMTase 3; HLA-B-associated transcript 8; Histone H3-K9 methyltransferase 3; Protein G9a", "protein_names_refseq": "H3-K9-HMTase 3; HLA-B associated transcript 8; histone H3-K9 methyltransferase 3; histone-lysine N-methyltransferase EHMT2 isoform c; histone-lysine N-methyltransferase EHMT2; histone-lysine N-methyltransferase, H3 lysine-9 specific 3; protein G9a", "tax_id": 10090, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); Kleefstra syndrome 1 (Disease Ontology:DOID:0060352); melanoma (Disease Ontology:DOID:1909); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung adenocarcinoma (Disease Ontology:DOID:3910); viral infectious disease (Disease Ontology:DOID:934); alopecia areata (Disease Ontology:DOID:986)", "pathway": " (mmu:110147); (R-MMU-2559582); (R-MMU-3214841); (R-MMU-6804760); (R-MMU-73762); (R-MMU-8953750)", "pathway_count": 6, "publication_count": 17, "publication_id_list": "11316813;11707778;12130538;14656967;15774718;16702210;18818694;19056828;21183079;21750661;22387026;22629437;24129315;27932493;28250819;38967255;39237663", "class_list": "", "function": "Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones (PubMed:11316813, PubMed:12130538, PubMed:15774718, PubMed:18818694). Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication (PubMed:22387026). Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. Also able to mono- and dimethylate histone H1-4 at 'Lys-26' (H1.4K26me1 and H1.4K26me2, respectively). In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Results indicate that euchromatic Histone H3 lysine 9 (H3-K9) methylation regulated by G9a is essential for early embryogenesis and is involved in the transcriptional repression of developmental genes., [RefSeq, PubMed]; The G9a histone methyltransferase represses osteoclastogenesis and bone resorption by regulating NFATc1 function., [RefSeq, PubMed]; The histone H3K9 methyltransferase G9a regulates tendon formation during development. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2CG75;Q6PE08;Q8K4R6;Q8K4R7;Q9Z149", "ec_number_list": [ { "id": "2.1.1.367", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.367", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.366", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.366", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.1.1.359", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0002039 p53 binding;GO:0016279 protein-lysine N-methyltransferase activity;GO:1990841 promoter-specific chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0000785 chromatin;GO:0005694 chromosome", "go_biological_process": "GO:1902902 negative regulation of autophagosome assembly;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0009566 fertilization;GO:0007286 spermatid development", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9Z148-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09542-1", "uniprot_id": [ { "id": "MYL3_MOUSE", "url": "https://www.uniprot.org/uniprot/P09542", "type": "external" } ], "mass": 22422.0, "length": 204, "protein_name": "Myosin light chain 3", "gene_name": "Myl3", "organism": "Mouse", "refseq_name": "myosin light chain 3", "refseq_ac": [ { "id": "NP_034989", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034989", "type": "external" } ], "gene_names_uniprotkb": "Myl3; Mlc1v; Mylc", "gene_names_refseq": "MLC1SB; MLC1s; MLC1v; Myl3; Mylc; VLC1", "protein_names_uniprotkb": "Myosin light chain 3; MLC1SB; Myosin alkali light chain 1, ventricular/slow skeletal muscle isoform; Myosin light chain 1, slow-twitch muscle B/ventricular isoform", "protein_names_refseq": "myosin light chain 3; myosin light chain, alkali, cardiac ventricles; myosin, light polypeptide 3, alkali; ventricular, skeletal, slow", "tax_id": 10090, "disease": "hypertrophic cardiomyopathy 8 (Disease Ontology:DOID:0110314); osteoarthritis (Disease Ontology:DOID:8398)", "pathway": " (mmu:17897); (R-MMU-390522)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "20668449;21183079;21750661;25428506;3194193;36288343;37507081;37794006;39927985", "class_list": "", "function": "MYL3 protects chondrocytes from senescence by inhibiting clathrin-mediated endocytosis and activating of Notch signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Regulatory light chain of myosin. Does not bind calcium., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UIF4;Q9CQZ2", "ec_number_list": [], "go_molecular_function": "GO:0003785 actin monomer binding;GO:0005509 calcium ion binding;GO:0003774 cytoskeletal motor activity", "go_cellular_component": "GO:0031674 I band;GO:0031672 A band;GO:0016459 myosin complex;GO:0016460 myosin II complex;GO:0016461 unconventional myosin complex", "go_biological_process": "GO:0030049 muscle filament sliding;GO:0060048 cardiac muscle contraction;GO:0002026 regulation of the force of heart contraction;GO:0006942 regulation of striated muscle contraction;GO:0055010 ventricular cardiac muscle tissue morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P09542-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TT50-1", "uniprot_id": [ { "id": "MRCKB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TT50", "type": "external" } ], "mass": 194753.0, "length": 1713, "protein_name": "Serine/threonine-protein kinase MRCK beta", "gene_name": "Cdc42bpb", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase MRCK beta", "refseq_ac": [ { "id": "NP_898837", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_898837", "type": "external" } ], "gene_names_uniprotkb": "Cdc42bpb; Kiaa1124", "gene_names_refseq": "Cdc42bpb; MRCKb", "protein_names_uniprotkb": "Serine/threonine-protein kinase MRCK beta; 2.7.11.1; CDC42-binding protein kinase beta; DMPK-like beta; MRCK beta; Myotonic dystrophy kinase-related CDC42-binding kinase beta; Myotonic dystrophy protein kinase-like beta", "protein_names_refseq": "DMPK-like beta; MRCK beta; myotonic dystrophy kinase related CDC42 binding kinase beta; myotonic dystrophy protein kinase like beta; serine/threonine-protein kinase MRCK beta", "tax_id": 10090, "disease": "cerebral cavernous malformation (Disease Ontology:DOID:0060669); azoospermia (Disease Ontology:DOID:14227)", "pathway": " (mmu:217866); (R-MMU-9013406)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "12522145;15289607;15592455;17242355;19144319;21183079;21750661;25107909;25428506;30084848;32848054;33300544;33933448;34428180;35820727", "class_list": "", "function": "First identified and named MRCKb based on sequence similarity to MRCKa (CDC42bpa) and orthology to human MRCKb/CDC42bpb, [RefSeq, PubMed]; MRCKbeta links Dasm1 to actin rearrangements to promote dendrite development., [RefSeq, PubMed]; Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A (By similarity). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (PubMed:25107909)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "E9QK15;Q69ZR5;Q80W33", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "1.16.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.1.-", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0030027 lamellipodium", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0016477 cell migration;GO:0030036 actin cytoskeleton organization;GO:0031032 actomyosin structure organization", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q7TT50-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99P21-1", "uniprot_id": [ { "id": "MUTYH_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99P21", "type": "external" } ], "mass": 57723.0, "length": 515, "protein_name": "Adenine DNA glycosylase", "gene_name": "Mutyh", "organism": "Mouse", "refseq_name": "adenine DNA glycosylase isoform a", "refseq_ac": [ { "id": "NP_001153053", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153053", "type": "external" } ], "gene_names_uniprotkb": "Mutyh; Myh", "gene_names_refseq": "5730495A01Rik; Mutyhalpha; Mutyha; Mutyhbeta; Mutyhb; Mutyhc; Mutyh; Myh", "protein_names_uniprotkb": "Adenine DNA glycosylase; 3.2.2.31; MutY homolog; mMYH", "protein_names_refseq": "a/G-specific adenine DNA glycosylase; adenine DNA glycosylase isoform a; mMYH; mutY homolog alpha", "tax_id": 10090, "disease": "familial adenomatous polyposis (Disease Ontology:DOID:0050424); familial adenomatous polyposis 2 (Disease Ontology:DOID:0080410); stomach cancer (Disease Ontology:DOID:10534); stomach carcinoma (Disease Ontology:DOID:5517)", "pathway": " (mmu:70603); (R-MMU-110331); (R-MMU-110357)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "11160897;11864576;14742662;21750661;25605945;30084848;30779550;33149810;33574380;34142156;34232996;34428180", "class_list": "", "function": "Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities., [UniProtKB, PubMed, PubMed]; MUTYH Deficiency Is Associated with Attenuated Pulmonary Fibrosis in a Bleomycin-Induced Model. Publication Status: Online-Only, [RefSeq, PubMed]; MUTYH is associated with hepatocarcinogenesis in a non-alcoholic steatohepatitis mouse model. Publication Status: Online-Only, [RefSeq, PubMed]; Replication-associated repair of adenine:8-oxoguanine mispairs by MYH, [RefSeq, PubMed]; Single molecule analysis indicates stimulation of MUTYH by UV-DDB through enzyme turnover., [RefSeq, PubMed]; Structure of the mammalian adenine DNA glycosylase MUTYH: insights into the base excision repair pathway and cancer., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AGE3", "ec_number_list": [ { "id": "3.1.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.2", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "3.2.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.31", "type": "external" } ], "go_molecular_function": "GO:0032357 oxidized purine DNA binding;GO:0034039 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0019104 DNA N-glycosylase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006281 DNA repair;GO:0006979 response to oxidative stress;GO:0006284 base-excision repair;GO:0006298 mismatch repair;GO:0060546 negative regulation of necroptotic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q99P21-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4VA55-1", "uniprot_id": [ { "id": "PWP3B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q4VA55", "type": "external" } ], "mass": 76989.0, "length": 681, "protein_name": "PWWP domain-containing DNA repair factor 3B", "gene_name": "Pwwp3b", "organism": "Mouse", "refseq_name": "PWWP domain-containing DNA repair factor 3B", "refseq_ac": [ { "id": "NP_001158102", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158102", "type": "external" } ], "gene_names_uniprotkb": "Pwwp3b; Mum1l1", "gene_names_refseq": "9430086K21Rik; Mum1l1; Pwwp3b", "protein_names_uniprotkb": "PWWP domain-containing DNA repair factor 3B; MUM1-like protein 1; Mutated melanoma-associated antigen 1-like protein 1; PWWP domain-containing protein MUM1L1; PWWP3B", "protein_names_refseq": "MUM1-like protein 1; PWWP domain-containing DNA repair factor 3B; PWWP domain-containing protein MUM1L1; melanoma associated antigen (mutated) 1-like 1; mutated melanoma-associated antigen 1-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:245631)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21183079;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AW67;Q0VBL8;Q7TSI2;Q8BS63", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4VA55-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13595-1", "uniprot_id": [ { "id": "NCAM1_MOUSE", "url": "https://www.uniprot.org/uniprot/P13595", "type": "external" } ], "mass": 119427.0, "length": 1115, "protein_name": "Neural cell adhesion molecule 1", "gene_name": "Ncam1", "organism": "Mouse", "refseq_name": "neural cell adhesion molecule 1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001074914", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074914", "type": "external" } ], "gene_names_uniprotkb": "Ncam1; Ncam", "gene_names_refseq": "CD56; E-NCAM; NCAM-1; Ncam1; Ncam", "protein_names_uniprotkb": "Neural cell adhesion molecule 1; N-CAM-1; NCAM-1", "protein_names_refseq": "N-CAM-1; neural cell adhesion molecule 1 isoform 1 precursor", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); ovarian serous carcinoma (Disease Ontology:DOID:0050933); acute promyelocytic leukemia (Disease Ontology:DOID:0060318); Alzheimer's disease (Disease Ontology:DOID:10652); opioid abuse (Disease Ontology:DOID:11206); hypothyroidism (Disease Ontology:DOID:1459); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); pancreatic cancer (Disease Ontology:DOID:1793); morphine dependence (Disease Ontology:DOID:2560); brain glioblastoma multiforme (Disease Ontology:DOID:3073); bipolar disorder (Disease Ontology:DOID:3312); middle cerebral artery infarction (Disease Ontology:DOID:3525); insulinoma (Disease Ontology:DOID:3892); cholangiocarcinoma (Disease Ontology:DOID:4947); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); adenoma (Disease Ontology:DOID:657); type 1 diabetes mellitus (Disease Ontology:DOID:9744); drug dependence (Disease Ontology:DOID:9974)", "pathway": " (mmu:17967); (R-MMU-375165); (R-MMU-419037); (R-MMU-445144); (R-MMU-5673001)", "pathway_count": 5, "publication_count": 32, "publication_id_list": "10.1101/2023.09.13.557529;10331878;10772929;14658030;15345747;16452087;18322192;19349973;19656770;21183079;21750661;22517741;22645316;22826440;2454455;25428506;2721486;28011936;28098160;30899004;32848054;33300544;3396534;3512556;35771867;3595563;3684567;37828378;40021952;40684658;40885482;8673600", "class_list": "glycogene", "function": "This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 11, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 11, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 11, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 44, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 13, "disease_count": 23, "glyco_site_count": 20, "binding_glycan_count": 0, "secondary_ac_list": "P13594;Q61949;Q61950;Q6LBU8;Q8BQ96;Q8C4B2;Q921P2;Q9R2A7", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0019902 phosphatase binding;GO:0030275 LRR domain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0034109 homotypic cell-cell adhesion;GO:0007166 cell surface receptor signaling pathway;GO:0007611 learning or memory;GO:0010288 response to lead ion;GO:0031175 neuron projection development", "synthesized_glycan_count": 0, "hit_score": 6.3, "record_id": "P13595-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001001.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2Q5T5-1", "uniprot_id": [ { "id": "MYMX_MOUSE", "url": "https://www.uniprot.org/uniprot/Q2Q5T5", "type": "external" } ], "mass": 9598.0, "length": 84, "protein_name": "Protein myomixer", "gene_name": "Mymx", "organism": "Mouse", "refseq_name": "protein myomixer isoform 1", "refseq_ac": [ { "id": "NP_001170939", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001170939", "type": "external" } ], "gene_names_uniprotkb": "Mymx; Gm7325", "gene_names_refseq": "EG653016; Esgp; Gm7325; Mymx; minion; myomerger", "protein_names_uniprotkb": "Protein myomixer; ESGP; Embryonic stem cell- and germ cell-specific protein; Microprotein inducer of fusion; Protein minion; Protein myomerger", "protein_names_refseq": "embryonic stem cell- and germ cell-specific protein; microprotein inducer of fusion; protein minion; protein myomerger; protein myomixer isoform 1; protein myomixer", "tax_id": 10090, "disease": "Carey-Fineman-Ziter syndrome 2 (Disease Ontology:DOID:0061116)", "pathway": " (mmu:653016)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "16331322;28386024;28569745;28569755;29581287;30197239;35642635", "class_list": "", "function": "Minion is a novel microprotein required for muscle development Publication Status: Online-Only, [RefSeq, PubMed]; Myoblast-specific protein that mediates myoblast fusion, an essential step for the formation of multi-nucleated muscle fibers (PubMed:28386024, PubMed:28569745, PubMed:28569755, PubMed:30197239). Involved in membrane fusion downstream of the lipid mixing step mediated by MYMK (PubMed:30197239). Acts by generating membrane stresses via its extracellular C-terminus, leading to drive fusion pore formation (PubMed:30197239). Acts independently of MYMK (PubMed:30197239). Involved in skeletal muscle regeneration in response to injury by mediating the fusion of satellite cells, a population of muscle stem cells, with injured myofibers (PubMed:29581287)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Myomerger is a fundamental myoblast fusion protein with roles in skeletal muscle development Publication Status: Online-Only, [RefSeq, PubMed]; The Myomixer-Myomaker pair controls the critical step in myofiber formation during muscle development., [RefSeq, PubMed]; The expression of ESGP is consistent with the expression of Oct-4 during embryonic development.Forced expression of ESGP is not indispensable for the effect of Oct-4 on ES cell self-renewal, and does not affect the differentiation to three germ layers., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9PXI1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0043403 skeletal muscle tissue regeneration;GO:0060538 skeletal muscle organ development;GO:0007520 myoblast fusion;GO:0014905 myoblast fusion involved in skeletal muscle regeneration;GO:0045026 plasma membrane fusion", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q2Q5T5-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K3H5-1", "uniprot_id": [ { "id": "MYO3A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K3H5", "type": "external" } ], "mass": 184730.0, "length": 1613, "protein_name": "Myosin-IIIa", "gene_name": "Myo3a", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Myo3a", "gene_names_refseq": "", "protein_names_uniprotkb": "Myosin-IIIa; 2.7.11.1", "protein_names_refseq": "", "tax_id": 10090, "disease": "autosomal dominant nonsyndromic deafness 90 (Disease Ontology:DOID:0070607); autosomal recessive nonsyndromic deafness 30 (Disease Ontology:DOID:0110489)", "pathway": " (mmu:667663)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12032315;19287378;21750661;25428507;26754646;26926603;34428180;35820727", "class_list": "", "function": "Actin-dependent motor protein with a protein kinase activity, playing an essential role in hearing (PubMed:26754646). Probably plays also a role in vision (By similarity). Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern (PubMed:26754646). Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments (PubMed:19287378)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0015629 actin cytoskeleton;GO:0030175 filopodium;GO:0001917 photoreceptor inner segment", "go_biological_process": "GO:0030832 regulation of actin filament length;GO:0007601 visual perception;GO:0046777 protein autophosphorylation;GO:0007605 sensory perception of sound;GO:0018107 peptidyl-threonine phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8K3H5-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99PD7-1", "uniprot_id": [ { "id": "NCKX3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99PD7", "type": "external" } ], "mass": 71942.0, "length": 645, "protein_name": "Sodium/potassium/calcium exchanger 3", "gene_name": "Slc24a3", "organism": "Mouse", "refseq_name": "sodium/potassium/calcium exchanger 3 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001343426", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001343426", "type": "external" } ], "gene_names_uniprotkb": "Slc24a3; Nckx3", "gene_names_refseq": "NCKX3; Slc24a3", "protein_names_uniprotkb": "Sodium/potassium/calcium exchanger 3; Na(+)/K(+)/Ca(2+)-exchange protein 3; Solute carrier family 24 member 3", "protein_names_refseq": "Na(+)/K(+)/Ca(2+)-exchange protein 3; sodium/potassium/calcium exchanger 3 isoform 1 precursor; sodium/potassium/calcium exchanger 3; solute carrier family 24 member 3", "tax_id": 10090, "disease": "epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:94249); (R-MMU-425561)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;11294880;19464262;19474185;21183079;22677781;28602864;33214341;33807999;34428180", "class_list": "", "function": "Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+)., [UniProtKB, PubMed]; Loss of Nckx3 Exacerbates Experimental DSS-Induced Colitis in Mice through p53/NF-kappaB Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; NCKX3 may play a role in regulating calcium homeostasis., [RefSeq, PubMed]; Potassium-dependent sodium/calcium exchanger 3 (Nckx3) depletion leads to abnormal motor function and social behavior in mice., [RefSeq, PubMed]; Suggest that a high level of renal NCKX3 expression maintain in distal convoluted tubules may play a role in active calcium transport in the kidneys of female mice., [RefSeq, PubMed]; The results of the present study indicate that NCKX3 is abundantly expressed in the uterus and that its expression is regulated by the steroid hormones E2 and P4., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B1AWL7;Q99JR2;Q99PD8", "ec_number_list": [], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0015293 symporter activity;GO:0008273 calcium, potassium:sodium antiporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression;GO:0006874 intracellular calcium ion homeostasis;GO:0006812 monoatomic cation transport;GO:0035725 sodium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q99PD7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DBR7-1", "uniprot_id": [ { "id": "MYPT1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DBR7", "type": "external" } ], "mass": 114996.0, "length": 1029, "protein_name": "Protein phosphatase 1 regulatory subunit 12A", "gene_name": "Ppp1r12a", "organism": "Mouse", "refseq_name": "protein phosphatase 1 regulatory subunit 12A isoform 2", "refseq_ac": [ { "id": "NP_082168", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082168", "type": "external" } ], "gene_names_uniprotkb": "Ppp1r12a; Mypt1", "gene_names_refseq": "1200015F06Rik; 5730577I22Rik; D10Ertd625e; Mypt1; Ppp1r12a", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 12A; Myosin phosphatase target subunit 1; Myosin phosphatase-targeting subunit 1", "protein_names_refseq": "myosin phosphatase target subunit 1; myosin phosphatase-targeting subunit 1; protein phosphatase 1 regulatory subunit 12A isoform 2; protein phosphatase 1, regulatory (inhibitor) subunit 12A", "tax_id": 10090, "disease": "", "pathway": " (mmu:17931); (R-MMU-2565942); (R-MMU-5625740); (R-MMU-5627123)", "pathway_count": 4, "publication_count": 36, "publication_id_list": "10.1101/2023.09.13.557529;10601309;11342221;17242355;18524939;20634291;21183079;21750661;22517741;22645316;22826440;25153642;25428506;25433069;29125738;30016717;30059200;30084848;31883643;32782141;32848054;34428180;34678516;34887587;35820727;35879418;36175407;36288343;36843141;36852467;38934703;39927985;40021952;40885482;40997131;8662509", "class_list": "", "function": "Gallbladder dysfunction caused by MYPT1 ablation triggers cholestasis-induced hepatic fibrosis in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; MYPT1 reduction is a pathogenic factor of erectile dysfunction. Publication Status: Online-Only, [RefSeq, PubMed]; MYPT1-PP1beta phosphatase negatively regulates both chromatin landscape and co-activator recruitment for beige adipogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; MYPT1[SMKO] Mice Function as a Novel Spontaneous Age- and Hypertension-Dependent Animal Model of CSVD., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 33, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 33, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 33, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 26, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 34, "binding_glycan_count": 0, "secondary_ac_list": "Q05A74;Q8CBV2;Q99NB6", "ec_number_list": [], "go_molecular_function": "GO:0017020 myosin phosphatase regulator activity;GO:0004857 enzyme inhibitor activity;GO:0019901 protein kinase binding;GO:0071889 14-3-3 protein binding;GO:0004721 phosphoprotein phosphatase activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0007165 signal transduction;GO:0030155 regulation of cell adhesion;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0046822 regulation of nucleocytoplasmic transport", "synthesized_glycan_count": 0, "hit_score": 7.3, "record_id": "Q9DBR7-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q01097-1", "uniprot_id": [ { "id": "NMDE2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q01097", "type": "external" } ], "mass": 165959.0, "length": 1482, "protein_name": "Glutamate receptor ionotropic, NMDA 2B", "gene_name": "Grin2b", "organism": "Mouse", "refseq_name": "glutamate receptor ionotropic, NMDA 2B precursor", "refseq_ac": [ { "id": "NP_032197", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032197", "type": "external" } ], "gene_names_uniprotkb": "Grin2b", "gene_names_refseq": "GluN2B; GluRepsilon2; Grin2b; NR2B; Nmdar2b", "protein_names_uniprotkb": "Glutamate receptor ionotropic, NMDA 2B; GluN2B; Glutamate [NMDA] receptor subunit epsilon-2; N-methyl D-aspartate receptor subtype 2B; NMDAR2B; NR2B", "protein_names_refseq": "N-methyl D-aspartate receptor subtype 2B; glutamate [NMDA] receptor subunit epsilon-2; glutamate receptor ionotropic, NMDA 2B precursor; glutamate receptor ionotropic, NMDA 2B", "tax_id": 10090, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); nicotine dependence (Disease Ontology:DOID:0050742); withdrawal disorder (Disease Ontology:DOID:0060001); developmental disorder of mental health (Disease Ontology:DOID:0060037); autosomal dominant intellectual developmental disorder 6 (Disease Ontology:DOID:0070036); developmental and epileptic encephalopathy 27 (Disease Ontology:DOID:0080444); retinitis pigmentosa (Disease Ontology:DOID:10584); Alzheimer's disease (Disease Ontology:DOID:10652); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); opioid abuse (Disease Ontology:DOID:11206); sciatic neuropathy (Disease Ontology:DOID:11446); Huntington's disease (Disease Ontology:DOID:12858); cognitive disorder (Disease Ontology:DOID:1561); alcohol use disorder (Disease Ontology:DOID:1574); epilepsy (Disease Ontology:DOID:1826); transient cerebral ischemia (Disease Ontology:DOID:224); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); bipolar disorder (Disease Ontology:DOID:3312); temporal lobe epilepsy (Disease Ontology:DOID:3328); placental insufficiency (Disease Ontology:DOID:3891); egg allergy (Disease Ontology:DOID:4377); schizophrenia (Disease Ontology:DOID:5419); vascular dementia (Disease Ontology:DOID:8725); hyperhomocysteinemia (Disease Ontology:DOID:9279); cannabis abuse (Disease Ontology:DOID:9505); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (mmu:14812); (R-MMU-3928662); (R-MMU-438066); (R-MMU-5673001); (R-MMU-8849932); (R-MMU-9609736)", "pathway_count": 6, "publication_count": 82, "publication_id_list": "10.1101/2023.09.13.557529;10846156;11024032;12008020;12451687;1377365;14602821;16190898;16452087;17045972;17114649;17329427;17460065;17526495;18034455;18716656;19243221;20141836;20722721;20979661;21054385;21118530;21167847;21183079;21750661;21800351;22479519;22492045;22516462;22523092;22544749;22640474;22645316;22909213;23082852;23672716;23866919;24787897;24860422;25100942;25128699;25158771;25890884;25992564;26093036;26494028;26912815;27094400;27134685;27422716;27752082;27785460;28358367;28359951;28649199;28729940;28838956;28912680;29101031;29497125;29577983;30024967;30089263;30233314;30504838;30572184;30899004;31196628;31424425;31787761;33158444;33243040;33250715;33300544;33443215;33478061;33661095;35180934;38452102;40885482;7790891;8789948", "class_list": "", "function": "Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:26912815). Participates in synaptic plasticity for learning and memory formation by contributing to the long-term depression (LTD) of hippocampus membrane currents (PubMed:8789948). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (Probable) (PubMed:1377365, PubMed:20141836, PubMed:7790891). NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium (By similarity). Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (By similarity). In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage (PubMed:20141836). Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (PubMed:20141836)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 7, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 15, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 16, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 16, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 21, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 19, "disease_count": 28, "glyco_site_count": 20, "binding_glycan_count": 0, "secondary_ac_list": "Q9DCB2", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0022849 glutamate-gated calcium ion channel activity;GO:0005102 signaling receptor binding;GO:0005262 calcium channel activity;GO:0008270 zinc ion binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0017146 NMDA selective glutamate receptor complex;GO:0048787 presynaptic active zone membrane;GO:0005737 cytoplasm;GO:0005856 cytoskeleton", "go_biological_process": "GO:1900452 regulation of long-term synaptic depression;GO:0001964 startle response;GO:0001701 in utero embryonic development;GO:0001967 suckling behavior;GO:0007611 learning or memory", "synthesized_glycan_count": 0, "hit_score": 12.2, "record_id": "Q01097-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K4Z3-1", "uniprot_id": [ { "id": "NNRE_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K4Z3", "type": "external" } ], "mass": 30973.0, "length": 282, "protein_name": "NAD(P)H-hydrate epimerase", "gene_name": "Naxe", "organism": "Mouse", "refseq_name": "NAD(P)H-hydrate epimerase isoform 2 precursor", "refseq_ac": [ { "id": "NP_659146", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659146", "type": "external" } ], "gene_names_uniprotkb": "Naxe; Aibp; Apoa1bp", "gene_names_refseq": "AI-BP; AIBP; Apoa1bp; Apoa1ip; ESTM37; Naxe", "protein_names_uniprotkb": "NAD(P)H-hydrate epimerase; 5.1.99.6; AI-BP; Apolipoprotein A-I-binding protein; NAD(P)HX epimerase", "protein_names_refseq": "NAD(P)H-hydrate epimerase isoform 2 precursor; NAD(P)H-hydrate epimerase; apoA-I binding protein; apolipoprotein A-I binding protein; apolipoprotein A-I interacting protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:246703); (R-MMU-196807)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "11991719;18202122;18614015;19131326;21183079;21994945;23806337;32152506;36288343;36429071;36719418;39342323;39927985", "class_list": "", "function": "AI-BP plays an important role in capacitation possibly providing a link between protein phosphorylation and cholesterol efflux., [RefSeq, PubMed]; AIBP Regulates Metabolism of Ketone and Lipids but Not Mitochondrial Respiration. Publication Status: Online-Only, [RefSeq, PubMed]; AIBP controls TLR4 inflammarafts and mitochondrial dysfunction in a mouse model of Alzheimer's disease. Publication Status: Online-Only, [RefSeq, PubMed]; AIBP regulates TRPV1 activation in chemotherapy-induced peripheral neuropathy by controlling lipid raft dynamics and proximity to TLR4 in dorsal root ganglion neurons., [RefSeq, PubMed]; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) (PubMed:21994945). This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX (By similarity). Accelerates cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis (By similarity)., [UniProtKB, HAMAP, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.1.99.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.6", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0000166 nucleotide binding;GO:0052856 NAD(P)HX epimerase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005929 cilium", "go_biological_process": "GO:0006869 lipid transport;GO:0016525 negative regulation of angiogenesis;GO:0002040 sprouting angiogenesis;GO:0010874 regulation of cholesterol efflux;GO:0046496 nicotinamide nucleotide metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8K4Z3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PFD9-1", "uniprot_id": [ { "id": "NUP98_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PFD9", "type": "external" } ], "mass": 197241.0, "length": 1816, "protein_name": "Nuclear pore complex protein Nup98-Nup96", "gene_name": "Nup98", "organism": "Mouse", "refseq_name": "nuclear pore complex protein Nup98-Nup96 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001274093", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001274093", "type": "external" } ], "gene_names_uniprotkb": "Nup98", "gene_names_refseq": "4732457F17; Nup96; Nup98", "protein_names_uniprotkb": "Nuclear pore complex protein Nup98-Nup96; 3.4.21.-; 96 kDa nucleoporin; 98 kDa nucleoporin; Nucleoporin Nup96; Nucleoporin Nup98; Nup96; Nup98", "protein_names_refseq": "nuclear pore complex protein Nup98-Nup96 isoform 1 precursor; nuclear pore complex protein Nup98-Nup96", "tax_id": 10090, "disease": "T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (mmu:269966); (R-MMU-141430); (R-MMU-141444); (R-MMU-159227); (R-MMU-159230); (R-MMU-159231); (R-MMU-159236); (R-MMU-170822); (R-MMU-1855170); (R-MMU-1855196); (R-MMU-1855229); (R-MMU-191859); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-3108214); (R-MMU-3232142); (R-MMU-3301854); (R-MMU-3371453); (R-MMU-4085377); (R-MMU-4551638); (R-MMU-4570464); (R-MMU-4615885); (R-MMU-5663220); (R-MMU-68877); (R-MMU-9615933); (R-MMU-9648025)", "pathway_count": 26, "publication_count": 21, "publication_id_list": "17242355;19144319;20485683;21183079;21606357;21750661;22480613;22645316;29187734;31219806;31599954;32652111;32782141;34428180;34582559;34887587;35820727;36852467;38940430;39627609;40997131", "class_list": "", "function": "NUP98-BPTF promotes oncogenic transformation through PIM1 upregulation., [RefSeq, PubMed]; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes. Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; TLR2/6 signaling promotes the expansion of premalignant hematopoietic stem and progenitor cells in the NUP98-HOXD13 mouse model of MDS., [RefSeq, PubMed]; The menin-MLL1 interaction is a molecular dependency in NUP98-rearranged AML., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 9, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 9, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 9, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 22, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q68G59", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.4.22.49", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.49", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" } ], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0042277 peptide binding;GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0031080 nuclear pore outer ring;GO:0044615 nuclear pore nuclear basket;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005643 nuclear pore", "go_biological_process": "GO:0048026 positive regulation of mRNA splicing, via spliceosome;GO:0006508 proteolysis;GO:0051292 nuclear pore complex assembly;GO:0051028 mRNA transport;GO:0000973 post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "Q6PFD9-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91YT0-1", "uniprot_id": [ { "id": "NDUV1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91YT0", "type": "external" } ], "mass": 50834.0, "length": 464, "protein_name": "NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial", "gene_name": "Ndufv1", "organism": "Mouse", "refseq_name": "NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial precursor", "refseq_ac": [ { "id": "NP_598427", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598427", "type": "external" } ], "gene_names_uniprotkb": "Ndufv1", "gene_names_refseq": "CI-51kD; Ndufv1", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; 7.1.1.2; CI-51kD; Complex I-51kD; NADH-ubiquinone oxidoreductase 51 kDa subunit; NDUFV1", "protein_names_refseq": "24 kDa (FP); NADH dehydrogenase (ubiquinone) flavoprotein 1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial precursor; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; NADH dehydrogenase flavoprotein 1; NADH-ubiquinone oxidoreductase 51 kDa subunit; complex I-51kD", "tax_id": 10090, "disease": "mitochondrial complex I deficiency (Disease Ontology:DOID:0060536); nuclear type mitochondrial complex I deficiency 4 (Disease Ontology:DOID:0112082); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (mmu:17995); (R-MMU-611105); (R-MMU-6799198); (R-MMU-9837999)", "pathway_count": 4, "publication_count": 19, "publication_id_list": "10870971;21750661;22820119;23038253;23576753;23806337;24129315;29915388;31219806;31536960;33300544;34428180;36288343;37029501;37453647;37507081;38575788;39927985;9571201", "class_list": "", "function": "Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; NDUFV1 attenuates renal ischemia-reperfusion injury by improving mitochondrial homeostasis., [RefSeq, PubMed]; The authors clone and characterize the human NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial protein, also known as NDUFV1. They identify transcription factor binding sites as well as consensus motifs for NADH, flavin mononucleotide, and iron-sulfur binding sites. The human ortholog has high homology to the cow NDUFV1 protein., [RefSeq, PubMed]; The authors provide an overview of the function and assembly of human complex I, also known as NADH dehydrogenase (ubiquinone) 1 alpha subcomplex. They discuss its role in oxidative phosphorylation and the implications of complex I deficiency in disease. Review article, [RefSeq, PubMed]; The authors use green fluorescent-tagged complex I subunits to determine the kinetics of assembly. Tagged human NDUFV1 can replace endogenous protein in the holo-complex I protein and was also found in complex I subassemblies, suggesting that NDUFV1 may directly incorporate into the holo-enzyme and may also assemble into smaller complexes or in a monomer pool., [RefSeq, PubMed]; This gene encodes a subunit of the NADH-ubiquinone oxidoreductase (complex I) enzyme, which is a large, multimeric protein. It is the first enzyme complex in the mitochondrial electron transport chain and catalyzes the transfer of electrons from NADH to the electron acceptor ubiquinone. The proton gradient created by electron transfer drives the conversion of ADP to ATP. This gene is a core subunit and is conserved in prokaryotes and eukaryotes. The human ortholog of this protein has been characterized. It has consensus motifs for NADH, flavin mononucleotide, and iron-sulfur binding sites and participates in the oxidation of NADH as part of the dehydrogenase module of complex I. In humans, deficiencies in complex I are associated with myopathies, encephalomyopathies, and neurodegenerative disorders. [provided by RefSeq, Jun 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "1.1.98.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.98.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "1.3.8.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.7", "type": "external" }, { "id": "1.3.8.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.8", "type": "external" }, { "id": "2.1.1.320", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.320", "type": "external" }, { "id": "2.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.2.1", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0051287 NAD binding;GO:0016491 oxidoreductase activity;GO:0008137 NADH dehydrogenase (ubiquinone) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0042775 mitochondrial ATP synthesis coupled electron transport;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q91YT0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54846-1", "uniprot_id": [ { "id": "NRL_MOUSE", "url": "https://www.uniprot.org/uniprot/P54846", "type": "external" } ], "mass": 26083.0, "length": 237, "protein_name": "Neural retina-specific leucine zipper protein", "gene_name": "Nrl", "organism": "Mouse", "refseq_name": "neural retina-specific leucine zipper protein isoform 1", "refseq_ac": [ { "id": "NP_001129546", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129546", "type": "external" } ], "gene_names_uniprotkb": "Nrl", "gene_names_refseq": "D14H14S46E; Nrl", "protein_names_uniprotkb": "Neural retina-specific leucine zipper protein; NRL", "protein_names_refseq": "neural retina-specific leucine zipper protein isoform 1; neural retina-specific leucine zipper protein", "tax_id": 10090, "disease": "enhanced S-cone syndrome 2 (Disease Ontology:DOID:0061232); enhanced S-cone syndrome (Disease Ontology:DOID:0090059); retinitis pigmentosa 27 (Disease Ontology:DOID:0110397); retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (mmu:18185)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11477108;20551322;21750661;22354990;8288222", "class_list": "", "function": "Acts as a transcriptional activator which regulates the expression of several rod-specific genes, including RHO and PDE6B. Also functions as a transcriptional coactivator, stimulating transcription mediated by the transcription factor CRX and NR2E3. Binds to the rhodopsin promoter in a sequence-specific manner., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene encodes a member of the basic leucine zipper domain family of transcription factors. The encoded protein is preferentially expressed in the retina and is necessary for rod photoreceptor development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0043522 leucine zipper domain binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P54846-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UFB7-1", "uniprot_id": [ { "id": "NTRK1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UFB7", "type": "external" } ], "mass": 87738.0, "length": 799, "protein_name": "High affinity nerve growth factor receptor", "gene_name": "Ntrk1", "organism": "Mouse", "refseq_name": "high affinity nerve growth factor receptor precursor", "refseq_ac": [ { "id": "NP_001028296", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028296", "type": "external" } ], "gene_names_uniprotkb": "Ntrk1", "gene_names_refseq": "Ntrk1; Tkr; TrkA; trk", "protein_names_uniprotkb": "High affinity nerve growth factor receptor; 2.7.10.1; Neurotrophic tyrosine kinase receptor type 1", "protein_names_refseq": "high affinity nerve growth factor receptor precursor; high affinity nerve growth factor receptor", "tax_id": 10090, "disease": "hereditary sensory and autonomic neuropathy (Disease Ontology:DOID:0050548); obstructive sleep apnea (Disease Ontology:DOID:0050848); colitis (Disease Ontology:DOID:0060180); congenital insensitivity to pain with anhidrosis (Disease Ontology:DOID:0070146); Parkinsonism (Disease Ontology:DOID:0080855); Hirschsprung's disease (Disease Ontology:DOID:10487); Alzheimer's disease (Disease Ontology:DOID:10652); pulmonary sarcoidosis (Disease Ontology:DOID:13406); glaucoma (Disease Ontology:DOID:1686); pancreatic cancer (Disease Ontology:DOID:1793); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); atopic dermatitis (Disease Ontology:DOID:3310); myofascial pain syndrome (Disease Ontology:DOID:431); rhinitis (Disease Ontology:DOID:4483); retinal detachment (Disease Ontology:DOID:5327); schizophrenia (Disease Ontology:DOID:5419); neuroblastoma (Disease Ontology:DOID:769); periodontitis (Disease Ontology:DOID:824); diabetic neuropathy (Disease Ontology:DOID:9743)", "pathway": " (mmu:18211); (R-MMU-1257604); (R-MMU-170968); (R-MMU-170984); (R-MMU-177504); (R-MMU-187042); (R-MMU-198203)", "pathway_count": 7, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;16113645;16223723;21816277;23785138;25428506;8145823;8815902", "class_list": "", "function": "Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 2, "disease_count": 20, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" } ], "go_molecular_function": "GO:0048406 nerve growth factor binding;GO:0043121 neurotrophin binding;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0046579 positive regulation of Ras protein signal transduction;GO:0021553 olfactory nerve development;GO:0060384 innervation;GO:0061368 behavioral response to formalin induced pain;GO:0042490 mechanoreceptor differentiation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q3UFB7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97799-1", "uniprot_id": [ { "id": "NRSN1_MOUSE", "url": "https://www.uniprot.org/uniprot/P97799", "type": "external" } ], "mass": 21595.0, "length": 196, "protein_name": "Neurensin-1", "gene_name": "Nrsn1", "organism": "Mouse", "refseq_name": "neurensin-1 isoform 1", "refseq_ac": [ { "id": "NP_033539", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033539", "type": "external" } ], "gene_names_uniprotkb": "Nrsn1; Vmp", "gene_names_refseq": "Neurensin-1; Neuro-p24; Nrsn1; Vmp", "protein_names_uniprotkb": "Neurensin-1; Neuro-p24; Vesicular membrane protein of 24 kDa; Vesicular membrane protein p24", "protein_names_refseq": "neurensin-1 isoform 1; vesicular membrane protein of 24 kDa; vesicular membrane protein p24", "tax_id": 10090, "disease": "", "pathway": " (mmu:22360)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12445626;16527258;16696124;17566649;26430118;34678516;9191101", "class_list": "", "function": "In behavioral analyses, overexpressing Nrsn1, one of the newly identified genes undergoing rapid translational repression, or activating ESR1 in the hippocampus impaired memory formation., [RefSeq, PubMed]; May play an important role in neural organelle transport, and in transduction of nerve signals or in nerve growth (PubMed:12445626, PubMed:16527258, PubMed:16696124, PubMed:9191101). May play a role in neurite extension (PubMed:26430118)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Neurensin-1 plays a role in the fiber extension of the retinal neurons, and indicate that the developing retina is a suitable experimental model for the analysis of Neurensin function, both in vivo and in vitro., [RefSeq, PubMed]; Neurensin-2 was expressed in small vesicles including lysosomes in the perinuclear region. And was found in cell bodies., [RefSeq, PubMed]; The results of this study indicate that Nrsn1 plays an active role in axonal regeneration as well as in embryonic development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0030426 growth cone;GO:0043025 neuronal cell body;GO:0031410 cytoplasmic vesicle;GO:0043005 neuron projection", "go_biological_process": "GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P97799-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AJN7-1", "uniprot_id": [ { "id": "S4A11_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AJN7", "type": "external" } ], "mass": 96751.0, "length": 862, "protein_name": "Solute carrier family 4 member 11", "gene_name": "Slc4a11", "organism": "Mouse", "refseq_name": "solute carrier family 4 member 11", "refseq_ac": [ { "id": "NP_001074631", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074631", "type": "external" } ], "gene_names_uniprotkb": "Slc4a11; BTR1", "gene_names_refseq": "BTR1; NaBC1; Slc4a11", "protein_names_uniprotkb": "Solute carrier family 4 member 11; NaBC1; Sodium borate cotransporter 1", "protein_names_refseq": "bicarbonate transporter-related protein 1; sodium bicarbonate transporter-like protein 11; sodium borate cotransporter 1; solute carrier family 4 member 11", "tax_id": 10090, "disease": "congenital hereditary endothelial dystrophy of cornea (Disease Ontology:DOID:0060649); corneal dystrophy-perceptive deafness syndrome (Disease Ontology:DOID:0111620); Fuchs' endothelial dystrophy (Disease Ontology:DOID:11555); anemia (Disease Ontology:DOID:2355)", "pathway": " (mmu:269356)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "19586905;20185830;21750661;23813972;23942972;25123669;25428506;30084848;33247189;34428180;34686736;34871568;35993514;37296649", "class_list": "", "function": "Altered gene expression in slc4a11(-/-) mouse cornea highlights SLC4A11 roles. Publication Status: Online-Only, [RefSeq, PubMed]; Corneal Edema in Inducible Slc4a11 Knockout Is Initiated by Mitochondrial Superoxide Induced Src Kinase Activation. Publication Status: Online-Only, [RefSeq, PubMed]; Corneal dystrophy mutations R125H and R804H disable SLC4A11 by altering the extracellular pH dependence of the intracellular pK that governs H(+)(OH(-)) transport., [RefSeq, PubMed]; Data shows that the function of SLCA11 is to facilitate the movement of water across the basolateral corneal epithelium., [RefSeq, PubMed]; Loss of SLC4A11 leads to morphological changes in the fibrocytes and deafness., [RefSeq, PubMed]; Multifunctional transporter with an impact in cell morphology and differentiation (PubMed:20185830). In the presence of borate B(OH)4(-), acts as a voltage-dependent electrogenic Na(+)-coupled B(OH)4(-) cotransporter controlling boron homeostasis (By similarity). At early stages of stem cell differentiation, participates in synergy with ITGA5-ITGB1 and ITGAV-ITGB3 integrins and BMPR1A to promote cell adhesion and contractility that drives differentiation toward osteogenic commitment while inhibiting adipogenesis (PubMed:33247189). In the absence of B(OH)4(-), acts as a Na(+)-coupled OH(-) or H(+) permeable channel with implications in cellular redox balance. Regulates the oxidative stress response in corneal endothelium by enhancing antioxidant defenses and protecting cells from reactive oxygen species. In response to hypo-osmotic challenge, also acts as water permeable channel at the basolateral cell membrane of corneal endothelial cells and facilitates transendothelial fluid reabsorption in the aqueous humor. In the presence of ammonia, acts as an electrogenic NH3/H(+) cotransporter and may play a role in ammonia transport and reabsorption in renal Henle's loop epithelium (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; RNA sequencing uncovers alterations in corneal endothelial metabolism, pump and barrier functions of Slc4a11 KO mice., [RefSeq, PubMed]; Results demonstrate the importance of NaBC1 in the audio-vestibular system and provide support for the hypothesis that SLC4A11 should be considered a potential candidate gene in patients with isolated sensorineural vestibular hearing abnormalities., [RefSeq, PubMed]; Successful knockout of the Slc4a11 gene was confirmed by immunohistochemistry and RT-PCR. Slit-lamp photography and AS-OCT showed progressive corneal edema. Publication Status: Online-Only, [RefSeq, PubMed]; The declined tumor cell survival following inhibition of BCT could be the consequence of interplay of several inter-connected regulatory molecular events., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q0VG86;Q3URQ1", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0046983 protein dimerization activity;GO:0015293 symporter activity;GO:0005372 water transmembrane transporter activity;GO:0005272 sodium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0012506 vesicle membrane", "go_biological_process": "GO:0071476 cellular hypotonic response;GO:0055085 transmembrane transport;GO:0051881 regulation of mitochondrial membrane potential;GO:0034599 cellular response to oxidative stress;GO:0006814 sodium ion transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "A2AJN7-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BXR1-1", "uniprot_id": [ { "id": "S7A14_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BXR1", "type": "external" } ], "mass": 83984.0, "length": 771, "protein_name": "Solute carrier family 7 member 14", "gene_name": "Slc7a14", "organism": "Mouse", "refseq_name": "solute carrier family 7 member 14", "refseq_ac": [ { "id": "NP_766449", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766449", "type": "external" } ], "gene_names_uniprotkb": "Slc7a14; Kiaa1613", "gene_names_refseq": "A930013N06; Slc7a14", "protein_names_uniprotkb": "Solute carrier family 7 member 14; Gamma-aminobutyric acid transporter SLC7A14", "protein_names_refseq": "gamma-aminobutyric acid transporter SLC7A14; probable cationic amino acid transporter; solute carrier family 7 member 14; solute carrier family 7, member 14", "tax_id": 10090, "disease": "retinitis pigmentosa 68 (Disease Ontology:DOID:0110374); sensorineural hearing loss (Disease Ontology:DOID:10003); blindness (Disease Ontology:DOID:1432)", "pathway": " (mmu:241919)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21183079;21750661;24670872;25428506;36640347;39261456", "class_list": "", "function": "Hypothalamic SLC7A14 accounts for aging-reduced lipolysis in white adipose tissue of male mice. Publication Status: Online-Only, [RefSeq, PubMed]; Imports 4-aminobutanoate (GABA) into lysosomes. May act as a GABA sensor that regulates mTORC2-dependent INS signaling and gluconeogenesis. The transport mechanism and substrate selectivity remain to be elucidated., [UniProtKB, PubMed]; SLC7A14 imports GABA to lysosomes and impairs hepatic insulin sensitivity via inhibiting mTORC2., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q69ZE9", "ec_number_list": [], "go_molecular_function": "GO:0015171 amino acid transmembrane transporter activity;GO:0015185 gamma-aminobutyric acid transmembrane transporter activity;GO:0046943 carboxylic acid transmembrane transporter activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005765 lysosomal membrane;GO:0016020 membrane", "go_biological_process": "GO:0006865 amino acid transport;GO:0051939 gamma-aminobutyric acid import", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BXR1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WVL3-1", "uniprot_id": [ { "id": "S12A7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WVL3", "type": "external" } ], "mass": 119481.0, "length": 1083, "protein_name": "Solute carrier family 12 member 7", "gene_name": "Slc12a7", "organism": "Mouse", "refseq_name": "solute carrier family 12 member 7 isoform 1", "refseq_ac": [ { "id": "NP_035520", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035520", "type": "external" } ], "gene_names_uniprotkb": "Slc12a7; Kcc4", "gene_names_refseq": "D13Ertd261e; Kcc4; Slc12a7", "protein_names_uniprotkb": "Solute carrier family 12 member 7; Electroneutral potassium-chloride cotransporter 4; K-Cl cotransporter 4", "protein_names_refseq": "K-Cl cotransporter 4; electroneutral potassium-chloride cotransporter 4; solute carrier family 12 member 7 isoform 1", "tax_id": 10090, "disease": "epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:20499); (R-MMU-426117)", "pathway_count": 2, "publication_count": 25, "publication_id_list": "10.1101/2023.09.13.557529;10347194;11551954;11976689;12106695;17242355;18322192;19144319;19349973;19656770;21183079;21750661;22872234;23376777;24089410;25605945;28276587;29237092;30084848;30779550;31219806;34203471;34428180;35820727;37507081", "class_list": "", "function": "Data are consistent with a role for KCC4 in salt reabsorption of the thick ascending loop of Henle's loop and acid secretion of the collecting duct., [RefSeq, PubMed]; Deafness and renal tubular acidosis in mice lacking the K-Cl co-transporter Kcc4 GeneRIF: Mice lacking SLC12A7 function suffer from deafness and renal metabolic acidosis. The phenotype suggests a function in inner ear potassium recycling. A function in the proton secreting alpha-intercalating cells of the kidney is shown., [RefSeq, PubMed]; During cell swelling PP1alpha and PP1gamma1 are involved in KCC4 regulation by WNK4, but that the kinase acts upon these phosphatases to inhibit their activity., [RefSeq, PubMed]; Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:11551954, PubMed:12106695). May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti (PubMed:11976689). May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (Probable)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 4, "mined_n_glycosites": 4, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q3TB23;Q3TDX1;Q3UE50;Q6KAS8", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0046872 metal ion binding;GO:0015379 potassium:chloride symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse;GO:0032991 protein-containing complex", "go_biological_process": "GO:0071333 cellular response to glucose stimulus;GO:0007268 chemical synaptic transmission;GO:0006884 cell volume homeostasis;GO:1902476 chloride transmembrane transport;GO:0055075 potassium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "Q9WVL3-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100100001001.111.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZ05-1", "uniprot_id": [ { "id": "E2AK4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QZ05", "type": "external" } ], "mass": 186487.0, "length": 1648, "protein_name": "eIF-2-alpha kinase GCN2", "gene_name": "Eif2ak4", "organism": "Mouse", "refseq_name": "eIF-2-alpha kinase GCN2 isoform 2", "refseq_ac": [ { "id": "NP_001171277", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171277", "type": "external" } ], "gene_names_uniprotkb": "Eif2ak4; Gcn2; Kiaa1338", "gene_names_refseq": "2610011M03; Eif2ak4; GCN2; MGCN2", "protein_names_uniprotkb": "eIF-2-alpha kinase GCN2; 2.7.11.1; Eukaryotic translation initiation factor 2-alpha kinase 4; GCN2-like protein; mGCN2", "protein_names_refseq": "GCN2 eIF2alpha kinase; GCN2-like protein; eIF-2-alpha kinase GCN2 isoform 2; eIF-2-alpha kinase GCN2", "tax_id": 10090, "disease": "pulmonary venoocclusive disease 2 (Disease Ontology:DOID:0081269); pulmonary venoocclusive disease (Disease Ontology:DOID:5453); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:27103)", "pathway_count": 1, "publication_count": 24, "publication_id_list": "10504407;10655230;11106749;12176355;12215525;15213227;15273307;15774759;16054071;16121183;16176978;16601681;19797084;20660158;21750661;23447528;24310610;24333428;25329545;25428506;26102367;31219806;34428180;36210013", "class_list": "", "function": "(Microbial infection) Plays a role in modulating the adaptive immune response to Yellow fever virus infection; promotes dendritic cells to initiate autophagy and antigene presentation to both CD4(+) and CD8(+) T-cells under amino acid starvation., [UniProtKB, PubMed]; (Microbial infection) Plays a role in the antiviral response against alphavirus infection; impairs early viral mRNA translation of the incoming genomic virus RNA, thus preventing alphavirus replication., [UniProtKB, PubMed]; Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to low amino acid availability (PubMed:10504407, PubMed:10655230, PubMed:12176355, PubMed:12215525, PubMed:15213227, PubMed:15774759, PubMed:16054071, PubMed:16121183, PubMed:16176978, PubMed:16601681, PubMed:26102367). Plays a role as an activator of the integrated stress response (ISR) required for adaptation to amino acid starvation (PubMed:10655230, PubMed:11106749, PubMed:12176355, PubMed:15213227, PubMed:16176978, PubMed:26102367). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha into a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, and thus to a reduced overall utilization of amino acids, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion (PubMed:10655230, PubMed:11106749, PubMed:12176355, PubMed:15213227, PubMed:16176978, PubMed:26102367). Required for the translational induction of protein kinase PRKCH following amino acid starvation (PubMed:19797084). Binds uncharged tRNAs (By similarity). Involved in cell cycle arrest by promoting cyclin D1 mRNA translation repression after the unfolded protein response pathway (UPR) activation or cell cycle inhibitor CDKN1A/p21 mRNA translation activation in response to amino acid deprivation (PubMed:16176978, PubMed:26102367). Plays a role in the consolidation of synaptic plasticity, learning as well as formation of long-term memory (PubMed:16121183). Plays a role in neurite outgrowth inhibition (PubMed:23447528). Plays a role in feeding behavior to maintain amino acid homeostasis; contributes to the innate aversion toward diets of imbalanced amino acid composition (PubMed:15774759, PubMed:16054071). Plays a proapoptotic role in response to glucose deprivation (PubMed:20660158). Promotes global cellular protein synthesis repression in response to UV irradiation independently of the stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) and p38 MAPK signaling pathways (PubMed:12176355)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Regulated translation initiation controls stress-induced gene expression in mammalian cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AUM3;A2AUM4;Q6GQT4;Q6ZPT5;Q8C5S0;Q8CIF5;Q9CT30;Q9CUV9;Q9ESB6;Q9ESB7;Q9ESB8", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0071074 eukaryotic initiation factor eIF2 binding;GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0022626 cytosolic ribosome", "go_biological_process": "GO:0070417 cellular response to cold;GO:0001934 positive regulation of protein phosphorylation;GO:0006468 protein phosphorylation;GO:0007612 learning;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q9QZ05-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D9V3-1", "uniprot_id": [ { "id": "ECHD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D9V3", "type": "external" } ], "mass": 35467.0, "length": 322, "protein_name": "Ethylmalonyl-CoA decarboxylase", "gene_name": "Echdc1", "organism": "Mouse", "refseq_name": "ethylmalonyl-CoA decarboxylase isoform b", "refseq_ac": [ { "id": "NP_001103665", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103665", "type": "external" } ], "gene_names_uniprotkb": "Echdc1", "gene_names_refseq": "1700028A24Rik; D10Ertd667e; Echdc1; MMCD", "protein_names_uniprotkb": "Ethylmalonyl-CoA decarboxylase; 4.1.1.94; Enoyl-CoA hydratase domain-containing protein 1; MMCD; Methylmalonyl-CoA decarboxylase", "protein_names_refseq": "enoyl-CoA hydratase domain-containing protein 1; ethylmalonyl-CoA decarboxylase isoform b; ethylmalonyl-CoA decarboxylase; methylmalonyl-CoA decarboxylase", "tax_id": 10090, "disease": "", "pathway": " (mmu:52665)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "21750661;22016388;23576753;23806337;30084848;30779550;31219806;34419447;34428180;37507081", "class_list": "", "function": "Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Acts preferentially on (S)-ethylmalonyl-CoA but also has some activity on the (R)-isomer. Also has methylmalonyl-CoA decarboxylase activity at lower level., [UniProtKB, UniProtKB, UniProtKB, PubMed]; ECHDC1 knockout mice accumulate ethyl-branched lipids and excrete abnormal intermediates of branched-chain fatty acid metabolism., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U8C0;Q3UM30;Q8C185;Q9CTC5", "ec_number_list": [ { "id": "4.1.1.94", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.94", "type": "external" } ], "go_molecular_function": "GO:0004492 methyl/ethyl malonyl-CoA decarboxylase activity;GO:0016831 carboxy-lyase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006635 fatty acid beta-oxidation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9D9V3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P25976-1", "uniprot_id": [ { "id": "UBF1_MOUSE", "url": "https://www.uniprot.org/uniprot/P25976", "type": "external" } ], "mass": 89509.0, "length": 765, "protein_name": "Nucleolar transcription factor 1", "gene_name": "Ubtf", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ubtf; Tcfubf; Ubf-1; Ubf1", "gene_names_refseq": "", "protein_names_uniprotkb": "Nucleolar transcription factor 1; UBF-1; Upstream-binding factor 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "childhood-onset neurodegeneration with brain atrophy (Disease Ontology:DOID:0070474)", "pathway": " (mmu:21429); (R-MMU-73728); (R-MMU-73762); (R-MMU-73772); (R-MMU-73863)", "pathway_count": 5, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;11698641;15197263;17182730;1891354;20168301;21183079;21750661;21930779;34428180;34887587;39627609", "class_list": "", "function": "Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0097110 scaffold protein binding;GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding;GO:0001165 RNA polymerase I cis-regulatory region sequence-specific DNA binding;GO:0001181 RNA polymerase I general transcription initiation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0001650 fibrillar center", "go_biological_process": "GO:0006360 transcription by RNA polymerase I;GO:1990830 cellular response to leukemia inhibitory factor;GO:0000183 rDNA heterochromatin formation;GO:0045943 positive regulation of transcription by RNA polymerase I;GO:0006362 transcription elongation by RNA polymerase I", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P25976-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TPW1-1", "uniprot_id": [ { "id": "NEXN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TPW1", "type": "external" } ], "mass": 72108.0, "length": 607, "protein_name": "Nexilin", "gene_name": "Nexn", "organism": "Mouse", "refseq_name": "nexilin isoform 2", "refseq_ac": [ { "id": "NP_955759", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955759", "type": "external" } ], "gene_names_uniprotkb": "Nexn", "gene_names_refseq": "1110046H09Rik; NELIN; Nexn", "protein_names_uniprotkb": "Nexilin; F-actin-binding protein", "protein_names_refseq": "F-actin-binding protein; nF actin binding protein; nexilin alpha; nexilin beta; nexilin gamma; nexilin isoform 2", "tax_id": 10090, "disease": "hypertrophic cardiomyopathy 20 (Disease Ontology:DOID:0110326); dilated cardiomyopathy 1CC (Disease Ontology:DOID:0110424)", "pathway": " (mmu:68810)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21183079;21750661;24866383;32814711;34887587;36288343;37507081", "class_list": "", "function": "Homozygous G650del nexilin variant causes cardiomyopathy in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; NEXN as a novel gene for ASD and its function to inhibit GATA4 established a critical regulation of an F-actin binding protein on a transcription factor in cardiac development, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QJX5;Q3TQP3;Q3UWU2;Q3UWU6;Q3UX39", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0008307 structural constituent of muscle;GO:0098632 cell-cell adhesion mediator activity;GO:0003779 actin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0005925 focal adhesion;GO:0015629 actin cytoskeleton;GO:0030424 axon", "go_biological_process": "GO:0009617 response to bacterium;GO:0030334 regulation of cell migration;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0051493 regulation of cytoskeleton organization;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q7TPW1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6VNS1-1", "uniprot_id": [ { "id": "NTRK3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6VNS1", "type": "external" } ], "mass": 92760.0, "length": 825, "protein_name": "NT-3 growth factor receptor", "gene_name": "Ntrk3", "organism": "Mouse", "refseq_name": "NT-3 growth factor receptor isoform a precursor", "refseq_ac": [ { "id": "NP_032772", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032772", "type": "external" } ], "gene_names_uniprotkb": "Ntrk3; TrkC", "gene_names_refseq": "Ntrk3_tv3; Ntrk3; TrkC", "protein_names_uniprotkb": "NT-3 growth factor receptor; 2.7.10.1; GP145-TrkC; Neurotrophic tyrosine kinase receptor type 3; Trk-C; TrkC tyrosine kinase", "protein_names_refseq": "GP145-TrkC; NT-3 growth factor receptor isoform a precursor; NT-3 growth factor receptor; neurotrophin-3; trk-C; trkC tyrosine kinase", "tax_id": 10090, "disease": "adenoid cystic carcinoma (Disease Ontology:DOID:0080202); stomach cancer (Disease Ontology:DOID:10534); invasive ductal carcinoma (Disease Ontology:DOID:3008); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); borna disease (Disease Ontology:DOID:5154); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:18213); (R-MMU-1257604); (R-MMU-388844); (R-MMU-6811558); (R-MMU-9034013); (R-MMU-9034793); (R-MMU-9603381)", "pathway_count": 7, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;14614136;18034455;21183079;21750661;23785138;25385546;25428506;30899004;33300544;9802700", "class_list": "", "function": "Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 6, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 8, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 8, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 8, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 8, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 13, "disease_count": 6, "glyco_site_count": 15, "binding_glycan_count": 0, "secondary_ac_list": "A4QPD0;Q9Z2P9;Q9Z2Q0", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" } ], "go_molecular_function": "GO:0043121 neurotrophin binding;GO:0005524 ATP binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity;GO:0002039 p53 binding;GO:0005030 neurotrophin receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol", "go_biological_process": "GO:0097107 postsynaptic density assembly;GO:0042490 mechanoreceptor differentiation;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007507 heart development;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "Q6VNS1-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88522-1", "uniprot_id": [ { "id": "NEMO_MOUSE", "url": "https://www.uniprot.org/uniprot/O88522", "type": "external" } ], "mass": 47972.0, "length": 412, "protein_name": "NF-kappa-B essential modulator", "gene_name": "Ikbkg", "organism": "Mouse", "refseq_name": "NF-kappa-B essential modulator isoform 1", "refseq_ac": [ { "id": "NP_001154895", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001154895", "type": "external" } ], "gene_names_uniprotkb": "Ikbkg; Nemo", "gene_names_refseq": "1110037D23Rik; IKK[g]; Ikbkg; NEMO", "protein_names_uniprotkb": "NF-kappa-B essential modulator; I-kappa-B kinase subunit gamma; IKK-gamma; IKKAP1; IKKG; IkB kinase subunit gamma; IkB kinase-associated protein 1; Inhibitor of nuclear factor kappa-B kinase subunit gamma; NEMO; NF-kappa-B essential modifier; mFIP-3", "protein_names_refseq": "I-kappa-B kinase subunit gamma; IKK-gamma; IKKAP1; IKKG; NF-kappa-B essential modifier; NF-kappa-B essential modulator isoform 1; NF-kappa-B essential modulator; ikB kinase subunit gamma; ikB kinase-associated protein 1; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; inhibitor of nuclear factor kappa-B kinase subunit gamma; mFIP-3", "tax_id": 10090, "disease": "ectodermal dysplasia and immunodeficiency 1 (Disease Ontology:DOID:0081078); immunodeficiency 33 (Disease Ontology:DOID:0112003); Bloch-Sulzberger syndrome (Disease Ontology:DOID:12305); Behcet's disease (Disease Ontology:DOID:13241); liver cancer (Disease Ontology:DOID:3571); hepatocellular carcinoma (Disease Ontology:DOID:684); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677); learning disability (Disease Ontology:DOID:8927); acute myocardial infarction (Disease Ontology:DOID:9408); steatotic liver disease (Disease Ontology:DOID:9452); irritable bowel syndrome (Disease Ontology:DOID:9778)", "pathway": " (mmu:16151); (R-MMU-1169091); (R-MMU-168638); (R-MMU-1810476); (R-MMU-202424); (R-MMU-2871837); (R-MMU-445989); (R-MMU-450302); (R-MMU-450321); (R-MMU-4755510); (R-MMU-5357905); (R-MMU-5357956); (R-MMU-5607764); (R-MMU-5684264); (R-MMU-5689880); (R-MMU-5689896); (R-MMU-9020702); (R-MMU-933542); (R-MMU-937039); (R-MMU-937041); (R-MMU-975144); (R-MMU-9758274); (R-MMU-9833482); (R-MMU-9860276); (R-MMU-9860927); (R-MMU-9909505)", "pathway_count": 26, "publication_count": 21, "publication_id_list": "11080499;11410370;11971901;12133833;16684768;17728323;19303852;19854204;20622870;21183079;21750661;31519886;32935379;34428180;35820727;37436447;37683611;38755681;9657155;9891086;9927690", "class_list": "", "function": "Damaged mitochondria recruit the effector NEMO to activate NF-kappaB signaling., [RefSeq, PubMed]; NEMO/NF-kappaB signaling functions as a double-edged sword in PanIN formation versus progression to pancreatic cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor (PubMed:9927690). Its binding to scaffolding polyubiquitin plays a key role in IKK activation by multiple signaling receptor pathways. Can recognize and bind both 'Lys-63'-linked and linear polyubiquitin upon cell stimulation, with a much higher affinity for linear polyubiquitin. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; USP10 regulates macrophage inflammation responses via stabilizing NEMO in LPS-induced sepsis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 17, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q924H4", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019904 protein domain specific binding;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "O88522-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52503-1", "uniprot_id": [ { "id": "NDUS6_MOUSE", "url": "https://www.uniprot.org/uniprot/P52503", "type": "external" } ], "mass": 13020.0, "length": 116, "protein_name": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial", "gene_name": "Ndufs6", "organism": "Mouse", "refseq_name": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial isoform 1 precursor", "refseq_ac": [ { "id": "NP_035018", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035018", "type": "external" } ], "gene_names_uniprotkb": "Ndufs6; Ip13", "gene_names_refseq": "IP13; Ndufs6", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial; CI-13kD-A; Complex I-13kD-A; NADH-ubiquinone oxidoreductase 13 kDa-A subunit", "protein_names_refseq": "CI-13kD-A; NADH dehydrogenase (ubiquinone) Fe-S protein 6; NADH dehydrogenase Fe-S protein 6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial isoform 1 precursor; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial; NADH-ubiquinone oxidoreductase 13 kDa-A subunit; complex I-13kD-A", "tax_id": 10090, "disease": "mitochondrial complex I deficiency (Disease Ontology:DOID:0060536); nuclear type mitochondrial complex I deficiency 9 (Disease Ontology:DOID:0112073); arteriosclerosis (Disease Ontology:DOID:2349); cervical cancer (Disease Ontology:DOID:4362)", "pathway": " (mmu:407785); (R-MMU-611105); (R-MMU-6799198)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "21750661;22474353;23320803;23576753;25605945;26495903;33323934;34428180;36288343;37507081;38575788;7607554", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]; Adult mesenchymal stem cell ageing interplays with depressed mitochondrial Ndufs6. Publication Status: Online-Only, [RefSeq, PubMed]; Data show that Ndufs6(gt/gt) mice are born healthy, attain normal weight and maturity, and are fertile, however, after 4 mo in males and 8 mo in females, Ndufs6(gt/gt) mice are at increased risk of cardiac failure and death., [RefSeq, PubMed]; The studies identify for the first time that complex I deficiency as the result of interruption of Ndufs6 is an independent cause of renal impairment., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5M9J7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0072359 circulatory system development;GO:0097168 mesenchymal stem cell proliferation;GO:0006631 fatty acid metabolic process;GO:0006936 muscle contraction;GO:0001822 kidney development", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P52503-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91V36-1", "uniprot_id": [ { "id": "NRBP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91V36", "type": "external" } ], "mass": 57348.0, "length": 499, "protein_name": "Nuclear receptor-binding protein 2", "gene_name": "Nrbp2", "organism": "Mouse", "refseq_name": "nuclear receptor-binding protein 2", "refseq_ac": [ { "id": "NP_001345288", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001345288", "type": "external" } ], "gene_names_uniprotkb": "Nrbp2", "gene_names_refseq": "Nrbp2", "protein_names_uniprotkb": "Nuclear receptor-binding protein 2", "protein_names_refseq": "nuclear receptor-binding protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:223649)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "18619852;21183079;21750661;34428180", "class_list": "", "function": "Data show that NRBP2 protein levels increase as neural progenitor cells differentiate, and its down regulation renders neural progenitor cells more vulnerable to apoptosis, which suggest a role in stem cell survival., [RefSeq, PubMed]; May regulate apoptosis of neural progenitor cells during their differentiation., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8R3M0", "ec_number_list": [], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004672 protein kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0012505 endomembrane system", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0043524 negative regulation of neuron apoptotic process;GO:0030182 neuron differentiation;GO:0016242 negative regulation of macroautophagy", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q91V36-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D2N9-1", "uniprot_id": [ { "id": "VP33A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D2N9", "type": "external" } ], "mass": 67555.0, "length": 598, "protein_name": "Vacuolar protein sorting-associated protein 33A", "gene_name": "Vps33a", "organism": "Mouse", "refseq_name": "vacuolar protein sorting-associated protein 33A isoform 1", "refseq_ac": [ { "id": "NP_084205", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084205", "type": "external" } ], "gene_names_uniprotkb": "Vps33a; Bf; Buff", "gene_names_refseq": "3830421M04Rik; Vps33a; bf", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 33A", "protein_names_refseq": "buff; vacuolar protein sorting 33A; vacuolar protein sorting-associated protein 33A isoform 1; vacuolar protein sorting-associated protein 33A; vacuolar sorting protein 33a", "tax_id": 10090, "disease": "Hermansky-Pudlak syndrome (Disease Ontology:DOID:3753)", "pathway": " (mmu:77573)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12538872;21750661;22872234;25266290;25428506;26259518;27628032;30084848;31219806;34428180", "class_list": "", "function": "Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with VPS16 but not VIPAS39. The function in autophagosome-lysosome fusion implicates STX17 but not UVRAG., [UniProtKB, UniProtKB]; VPS33A(D251E) mutation plays dual roles by increasing the HOPS complex assembly and its association with the autophagic SNARE complex, which selectively affects the autophagosome-lysosome fusion., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BGT3", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0030897 HOPS complex;GO:0005769 early endosome;GO:0048471 perinuclear region of cytoplasm;GO:0005764 lysosome;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0006886 intracellular protein transport;GO:0008333 endosome to lysosome transport;GO:0016192 vesicle-mediated transport;GO:0030220 platelet formation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9D2N9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K1X1-1", "uniprot_id": [ { "id": "WDR11_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K1X1", "type": "external" } ], "mass": 135937.0, "length": 1223, "protein_name": "WD repeat-containing protein 11", "gene_name": "Wdr11", "organism": "Mouse", "refseq_name": "WD repeat-containing protein 11", "refseq_ac": [ { "id": "NP_758459", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_758459", "type": "external" } ], "gene_names_uniprotkb": "Wdr11; Brwd2; Kiaa1351", "gene_names_refseq": "2900055P10Rik; Brwd2; Wdr11; mKIAA1351", "protein_names_uniprotkb": "WD repeat-containing protein 11; Bromodomain and WD repeat-containing protein 2", "protein_names_refseq": "WD repeat-containing protein 11; bromodomain and WD repeat domain containing 2; bromodomain and WD repeat-containing protein 2", "tax_id": 10090, "disease": "autosomal recessive intellectual developmental disorder (Disease Ontology:DOID:0060308); ciliopathy (Disease Ontology:DOID:0060340); hypogonadotropic hypogonadism 14 with or without anosmia (Disease Ontology:DOID:0090087); Kallmann syndrome (Disease Ontology:DOID:3614)", "pathway": " (mmu:207425); (R-MMU-9013407)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;20887964;21183079;21750661;29084197;29263200;31219806;34428180;35820727", "class_list": "", "function": "Involved in the Hedgehog (Hh) signaling pathway, is essential for normal ciliogenesis (PubMed:29263200). Regulates the proteolytic processing of GLI3 and cooperates with the transcription factor EMX1 in the induction of downstream Hh pathway gene expression and gonadotropin-releasing hormone production (PubMed:29263200). WDR11 complex facilitates the tethering of Adaptor protein-1 complex (AP-1)-derived vesicles. WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1 (By similarity)., [UniProtKB, UniProtKB, PubMed]; Involved in the Hedgehog (Hh) signaling pathway, is essential for normal ciliogenesis. Regulates the proteolytic processing of GLI3 and cooperates with the transcription factor EMX1 in the induction of downstream Hh pathway gene expression and gonadotropin-releasing hormone production. WDR11 complex facilitates the tethering of Adaptor protein-1 complex (AP-1)-derived vesicles. WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1., [UniProtKB, UniProtKB]; Our study reveals a novel class of ciliopathy caused by WDR11 mutations and suggests that CHH/KS may be a part of the human ciliopathy spectrum., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q69ZL3;Q8C937", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0007507 heart development;GO:0035264 multicellular organism growth;GO:0060271 cilium assembly;GO:0008589 regulation of smoothened signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8K1X1-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15920-1", "uniprot_id": [ { "id": "VPP2_MOUSE", "url": "https://www.uniprot.org/uniprot/P15920", "type": "external" } ], "mass": 98145.0, "length": 856, "protein_name": "V-type proton ATPase 116 kDa subunit a 2", "gene_name": "Atp6v0a2", "organism": "Mouse", "refseq_name": "V-type proton ATPase 116 kDa subunit a 2", "refseq_ac": [ { "id": "NP_035726", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035726", "type": "external" } ], "gene_names_uniprotkb": "Atp6v0a2; Atp6n1b; Tj6", "gene_names_refseq": "8430408C20Rik; ATP6a2; Atp6n1d; Atp6n2; Atp6v0a2; ISF; J6B7; SHIF; Stv1; TJ6M; TJ6s; Tj6; V-ATPase 116 kDa; V-ATPase a2", "protein_names_uniprotkb": "V-type proton ATPase 116 kDa subunit a 2; ISF; Immune suppressor factor J6B7; Lysosomal H(+)-transporting ATPase V0 subunit a 2; ShIF; V-ATPase 116 kDa subunit a 2; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2", "protein_names_refseq": "ATPase, H+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 2 (38kD); ATPase, H+ transporting, lysosomal V0 subunit a; T-cell expressing clone j6; V-ATPase 116 kDa subunit a 2; V-ATPase 116 kDa subunit a2; V-type proton ATPase 116 kDa subunit a 2; V-type proton ATPase 116 kDa subunit a2; V-type proton ATPase 116 kDa subunit a; immune suppressor factor J6B7; lysosomal H(+)-transporting ATPase V0 subunit a 2; vacuolar proton translocating ATPase 116 kDa subunit a", "tax_id": 10090, "disease": "autosomal recessive cutis laxa type IIA (Disease Ontology:DOID:0070134); autosomal recessive osteopetrosis 1 (Disease Ontology:DOID:0110942); wrinkly skin syndrome (Disease Ontology:DOID:0112171); renal tubular acidosis (Disease Ontology:DOID:14219); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:21871); (R-MMU-1222556); (R-MMU-77387); (R-MMU-917977); (R-MMU-983712)", "pathway_count": 5, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;10702241;10722719;11375395;16415858;17242355;21183079;21750661;2247090;22872234;25428506;30084848;34428180", "class_list": "", "function": "Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase., [UniProtKB, UniProtKB]; Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Essential component of the endosomal pH-sensing machinery (PubMed:16415858). May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; This gene encodes a subunit of vacuolar ATPase, a multimeric enzyme that localizes to intracellular vesicles and to the plasma membrane of specialized cells. The encoded protein is a component of the V(0) domain, which functions in proton translocation across membranes. Function of this gene is important in fetal-specific immune suppression during pregnancy. [provided by RefSeq, May 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9820, "biomarker_type": "", "glycan_count": 2, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A4FU82;Q3U2X3;Q8VHU0;Q9JHJ2", "ec_number_list": [], "go_molecular_function": "GO:0051117 ATPase binding;GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0097229 sperm end piece;GO:0033176 proton-transporting V-type ATPase complex;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis;GO:0036295 cellular response to increased oxygen levels;GO:0007035 vacuolar acidification;GO:0038020 insulin receptor recycling", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P15920-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47993-1", "uniprot_id": [ { "id": "XCL1_MOUSE", "url": "https://www.uniprot.org/uniprot/P47993", "type": "external" } ], "mass": 12467.0, "length": 114, "protein_name": "Lymphotactin", "gene_name": "Xcl1", "organism": "Mouse", "refseq_name": "lymphotactin precursor", "refseq_ac": [ { "id": "NP_032536", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032536", "type": "external" } ], "gene_names_uniprotkb": "Xcl1; Lptn; Ltn; Scyc1", "gene_names_refseq": "ATAC; LTN; Lptn; SCM-1a; SCM-1; Scyc1; Xcl1", "protein_names_uniprotkb": "Lymphotactin; C motif chemokine 1; Cytokine SCM-1; Lymphotaxin; Small-inducible cytokine C1", "protein_names_refseq": "c motif chemokine 1; chemokine XCL1; cytokine SCM-1; lymphotactin precursor; lymphotactin; lymphotaxin; small inducible cytokine subfamily C, member 1 (lymphotactin); small-inducible cytokine C1", "tax_id": 10090, "disease": "anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780)", "pathway": " (mmu:16963); (R-MMU-380108); (R-MMU-416476)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "21300913;26495903;28550205;30542351;7875320;7973732;9199871", "class_list": "", "function": "A highly active form of XCL1 is a promising vaccine adjuvant for cross-presenting DCs to induce antigen-specific effector and memory CD8(+) T cells. Publication Status: Online-Only, [RefSeq, PubMed]; Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment., [UniProtKB, PubMed]; Study provides in vitro and in vivo evidence that the interaction between XCL1 and alpha9 integrin has an important role for autoimmune diseases, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0008009 chemokine activity;GO:0042379 chemokine receptor binding;GO:0048020 CCR chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0032703 negative regulation of interleukin-2 production;GO:0006935 chemotaxis;GO:0006954 inflammatory response;GO:0010820 positive regulation of T cell chemotaxis;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P47993-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P59328-1", "uniprot_id": [ { "id": "WDHD1_MOUSE", "url": "https://www.uniprot.org/uniprot/P59328", "type": "external" } ], "mass": 124254.0, "length": 1117, "protein_name": "WD repeat and HMG-box DNA-binding protein 1", "gene_name": "Wdhd1", "organism": "Mouse", "refseq_name": "WD repeat and HMG-box DNA-binding protein 1 isoform 2", "refseq_ac": [ { "id": "NP_766186", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766186", "type": "external" } ], "gene_names_uniprotkb": "Wdhd1; And1", "gene_names_refseq": "A630092E18; AND-1; D630024B06Rik; Wdhd1", "protein_names_uniprotkb": "WD repeat and HMG-box DNA-binding protein 1; Acidic nucleoplasmic DNA-binding protein 1; And-1", "protein_names_refseq": "WD repeat and HMG-box DNA-binding protein 1 isoform 2; acidic nucleoplasmic DNA-binding protein 1", "tax_id": 10090, "disease": "cholangiocarcinoma (Disease Ontology:DOID:4947)", "pathway": " (mmu:218973)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "19131326;19144319;21183079;21750661;23806337;29237092;33716172;36194437;39627609", "class_list": "", "function": "Chromatin remodelers HELLS, WDHD1 and BAZ1A are dynamically expressed during mouse spermatogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Core replisome component that acts as a replication initiation factor. Binds directly to the CMG complex and functions as a hub to recruit additional proteins to the replication fork., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Wdhd1 is essential for early mouse embryogenesis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6P408", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0070063 RNA polymerase binding", "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0005654 nucleoplasm;GO:0000775 chromosome, centromeric region", "go_biological_process": "GO:0033044 regulation of chromosome organization;GO:0000278 mitotic cell cycle;GO:0006281 DNA repair;GO:0006396 RNA processing;GO:0006261 DNA-templated DNA replication", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P59328-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5W1-1", "uniprot_id": [ { "id": "VPS8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q0P5W1", "type": "external" } ], "mass": 161146.0, "length": 1427, "protein_name": "Vacuolar protein sorting-associated protein 8 homolog", "gene_name": "Vps8", "organism": "Mouse", "refseq_name": "vacuolar protein sorting-associated protein 8 homolog isoform 1", "refseq_ac": [ { "id": "NP_001272822", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001272822", "type": "external" } ], "gene_names_uniprotkb": "Vps8; Kiaa0804", "gene_names_refseq": "Vps8; mKIAA0804", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 8 homolog", "protein_names_refseq": "vacuolar protein sorting 8 homolog; vacuolar protein sorting-associated protein 8 homolog isoform 1; vacuolar protein sorting-associated protein 8 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:209018)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "21750661;25266290;25428506;30084848;30779550;33289187;34428180;35820727", "class_list": "", "function": "Low pup survival rate is associated with maternal Naq3 genotype and hypothalamic Vps8 expression levels in mice., [RefSeq, PubMed]; Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Functions predominantly in APPL1-containing endosomes (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UR93;Q80TR5;Q8K280", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005770 late endosome;GO:0033263 CORVET complex", "go_biological_process": "GO:0034058 endosomal vesicle fusion;GO:0006623 protein targeting to vacuole", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q0P5W1-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UVL4-1", "uniprot_id": [ { "id": "VPS51_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UVL4", "type": "external" } ], "mass": 86187.0, "length": 782, "protein_name": "Vacuolar protein sorting-associated protein 51 homolog", "gene_name": "Vps51", "organism": "Mouse", "refseq_name": "vacuolar protein sorting-associated protein 51 homolog", "refseq_ac": [ { "id": "NP_001074510", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074510", "type": "external" } ], "gene_names_uniprotkb": "Vps51; Ffr", "gene_names_refseq": "1110014N23Rik; 3110057M17Rik; Ffr; Vps51", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 51 homolog; Protein fat-free homolog", "protein_names_refseq": "protein fat-free homolog; vacuolar protein sorting 51 homolog; vacuolar protein sorting-associated protein 51 homolog", "tax_id": 10090, "disease": "pontocerebellar hypoplasia type 13 (Disease Ontology:DOID:0112332)", "pathway": " (mmu:68505); (R-MMU-6811440)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;20484733;21183079;21750661;25428506;25428507;25605945;27802388;30084848;30779550;30962439;31219806;31599954;33300544;34203471;34428180;35820727", "class_list": "", "function": "Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN. Acts as a component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane., [UniProtKB, UniProtKB]; Involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. Acts as component of the EARP complex that is involved in endocytic recycling., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q0VF89;Q0VF90;Q3UK22;Q9CXM6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000938 GARP complex;GO:1990745 EARP complex;GO:0005730 nucleolus;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0015031 protein transport;GO:0006605 protein targeting;GO:0006914 autophagy;GO:0042147 retrograde transport, endosome to Golgi;GO:0048854 brain morphogenesis", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q3UVL4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TSP5-1", "uniprot_id": [ { "id": "VTCN1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TSP5", "type": "external" } ], "mass": 30875.0, "length": 283, "protein_name": "V-set domain containing T-cell activation inhibitor 1", "gene_name": "Vtcn1", "organism": "Mouse", "refseq_name": "V-set domain containing T-cell activation inhibitor 1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_848709", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848709", "type": "external" } ], "gene_names_uniprotkb": "Vtcn1; B7h4", "gene_names_refseq": "B7h4; B7s1; B7x; Vtcn1", "protein_names_uniprotkb": "V-set domain containing T-cell activation inhibitor 1; B7 homolog 4; B7-H4; Immune costimulatory protein B7-H4; Protein B7S1; T cell costimulatory molecule B7x", "protein_names_refseq": "B7 homolog 4; V-set domain containing T-cell activation inhibitor 1 isoform 1 precursor; immune costimulatory protein B7-H4; t cell costimulatory molecule B7x", "tax_id": 10090, "disease": "", "pathway": " (mmu:242122)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12818165;12818166;12920180;14568939;16914726;35364006;35505420;36514159;37963469", "class_list": "", "function": "A SOX9-B7x axis safeguards dedifferentiated tumor cells from immune surveillance to drive breast cancer progression., [RefSeq, PubMed]; B7-H4 reduction induced by Toxoplasma gondii infection results in dysfunction of decidual dendritic cells by regulating the JAK2/STAT3 pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Effect of B7-H4 downregulation induced by Toxoplasma gondii infection on dysfunction of decidual macrophages contributes to adverse pregnancy outcomes. Publication Status: Online-Only, [RefSeq, PubMed]; Genomic DNA of mouse B7-H4 is mapped on chromosome 3 comprised of six exons and five introns spanning 66 kb., [RefSeq, PubMed]; May participate in negative regulation of cell-mediated immunity in peripheral tissues, [RefSeq, PubMed]; Microbiota-dependent activation of the myeloid calcineurin-NFAT pathway inhibits B7H3- and B7H4-dependent anti-tumor immunity in colorectal cancer., [RefSeq, PubMed]; Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Novel negative costimulator and regulates the threshold of T cell activation, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q7TPH5;Q8K091", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0042130 negative regulation of T cell proliferation;GO:0050852 T cell receptor signaling pathway;GO:0002250 adaptive immune response;GO:0001817 regulation of cytokine production", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q7TSP5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CFJ9-1", "uniprot_id": [ { "id": "WDR24_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CFJ9", "type": "external" } ], "mass": 88184.0, "length": 790, "protein_name": "GATOR2 complex protein WDR24", "gene_name": "Wdr24", "organism": "Mouse", "refseq_name": "GATOR2 complex protein WDR24", "refseq_ac": [ { "id": "NP_776102", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776102", "type": "external" } ], "gene_names_uniprotkb": "Wdr24", "gene_names_refseq": "Wdr24", "protein_names_uniprotkb": "GATOR2 complex protein WDR24; 2.3.2.27; WD repeat-containing protein 24", "protein_names_refseq": "GATOR complex protein WDR24; GATOR2 complex protein WDR24; WD repeat-containing protein 24", "tax_id": 10090, "disease": "", "pathway": " (mmu:268933); (R-MMU-9639288)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21183079;25428506;36528027;36732624", "class_list": "", "function": "AMPK-dependent phosphorylation of the GATOR2 component WDR24 suppresses glucose-mediated mTORC1 activation., [RefSeq, PubMed]; Catalytic component of the GATOR2 complex, a multiprotein complex that acts as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway (PubMed:36528027). The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex (By similarity). GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1 (By similarity). In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation (By similarity). In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex (By similarity). In addition to its role in regulation of the mTORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux (By similarity). Within the GATOR2 complex, WDR24 constitutes the catalytic subunit that mediates 'Lys-6'-linked ubiquitination of NPRL2 (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005765 lysosomal membrane;GO:0005774 vacuolar membrane;GO:0061700 GATOR2 complex", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0010506 regulation of autophagy;GO:0072659 protein localization to plasma membrane;GO:0045860 positive regulation of protein kinase activity;GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8CFJ9-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1G4-1", "uniprot_id": [ { "id": "VPP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z1G4", "type": "external" } ], "mass": 96467.0, "length": 839, "protein_name": "V-type proton ATPase 116 kDa subunit a 1", "gene_name": "Atp6v0a1", "organism": "Mouse", "refseq_name": "V-type proton ATPase 116 kDa subunit a 1 isoform 3", "refseq_ac": [ { "id": "NP_001229979", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001229979", "type": "external" } ], "gene_names_uniprotkb": "Atp6v0a1; Atp6n1", "gene_names_refseq": "ATP6a1; Atp6n1a; Atp6n1; Atp6v0a1; Atpv0a1; Vpp-1; Vpp1", "protein_names_uniprotkb": "V-type proton ATPase 116 kDa subunit a 1; Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit; V-ATPase 116 kDa subunit a 1; Vacuolar adenosine triphosphatase subunit Ac116; Vacuolar proton pump subunit 1; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1", "protein_names_refseq": "ATPase, H+ transporting, lysosomal (vacuolar proton pump) noncatalytic accessory protein 1 (110/160 kDa); ATPase, H+ transporting, lysosomal (vacuolar proton pump) noncatalytic accessory protein 1A (110/160 kDa); ATPase, H+ transporting, lysosomal V0 subunit a; V-ATPase 116 kDa subunit a 1; V-ATPase 116 kDa subunit a1; V-ATPase a1; V-type proton ATPase 116 kDa subunit a 1 isoform 3; V-type proton ATPase 116 kDa subunit a 1; V-type proton ATPase 116 kDa subunit a1; V-type proton ATPase 116 kDa subunit a; clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit; vacuolar adenosine triphosphatase subunit Ac116; vacuolar proton pump subunit 1; vacuolar proton translocating ATPase 116 kDa subunit a", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 104 (Disease Ontology:DOID:0070390); autosomal recessive osteopetrosis 1 (Disease Ontology:DOID:0110942); renal tubular acidosis (Disease Ontology:DOID:14219); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:11975); (R-MMU-1222556); (R-MMU-6798695); (R-MMU-77387); (R-MMU-917977); (R-MMU-983712)", "pathway_count": 6, "publication_count": 10, "publication_id_list": "10702241;10722719;18034455;21183079;21750661;28024296;33300544;33833240;34428180;36042358", "class_list": "", "function": "ATP6V0A1 encoding the a1-subunit of the V0 domain of vacuolar H(+)-ATPases is essential for brain development in humans and mice. Publication Status: Online-Only, [RefSeq, PubMed]; Adipocytes control food intake and weight regain via Vacuolar-type H(+) ATPase. Publication Status: Online-Only, [RefSeq, PubMed]; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase., [UniProtKB, UniProtKB]; Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for the acidification of various organelles, such as lysosomes, endosomes, the trans-Golgi network, and secretory granules, including synaptic vesicles. In certain cell types, can be exported to the plasma membrane, where it is involved in the acidification of the extracellular environment (By similarity). The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment (By similarity). Required for assembly and activity of the vacuolar ATPase (By similarity). Through its action on compartment acidification, plays an essential role in neuronal development in terms of integrity and connectivity of neurons (PubMed:33833240)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2A5A1;Q9JHJ4;Q9JL13;Q9JL14", "ec_number_list": [], "go_molecular_function": "GO:0051117 ATPase binding;GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0016241 regulation of macroautophagy;GO:0097401 synaptic vesicle lumen acidification;GO:0007035 vacuolar acidification", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9Z1G4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4VA61-1", "uniprot_id": [ { "id": "DSCL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q4VA61", "type": "external" } ], "mass": 224240.0, "length": 2053, "protein_name": "Cell adhesion molecule DSCAML1", "gene_name": "Dscaml1", "organism": "Mouse", "refseq_name": "cell adhesion molecule DSCAML1 precursor", "refseq_ac": [ { "id": "NP_001074739", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074739", "type": "external" } ], "gene_names_uniprotkb": "Dscaml1", "gene_names_refseq": "4921507G06Rik; 4930435C18Rik; Dscaml1; mKIAA1132", "protein_names_uniprotkb": "Cell adhesion molecule DSCAML1; Down syndrome cell adhesion molecule-like protein 1 homolog", "protein_names_refseq": "Down syndrome cell adhesion molecule like 1; Down syndrome cell adhesion molecule-like protein 1 homolog; cell adhesion molecule DSCAML1 precursor; cell adhesion molecule DSCAML1", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); ocular motor apraxia, Cogan type (Disease Ontology:DOID:0080849); ocular motility disease (Disease Ontology:DOID:1279); Down syndrome (Disease Ontology:DOID:14250)", "pathway": " (mmu:114873); (R-MMU-376172)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;19945391;21750661;27637097;30899004;33256836;34428180;36210013;37910517;40885482", "class_list": "", "function": "Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Promotes both isoneuronal self-avoidance for creating an orderly neurite arborization in retinal rod bipolar cells and heteroneuronal self-avoidance to maintain mosaic spacing between AII amacrine cells (PubMed:19945391). Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; Down syndrome cell adhesion molecule like-1 (DSCAML1) links the GABA system and seizure susceptibility. Publication Status: Online-Only, [RefSeq, PubMed]; The rod synapse in aging wildtype and Dscaml1 mutant mice. Publication Status: Online-Only, [RefSeq, PubMed]; Together, these results demonstrate that different cell types have different dependencies on the PDZ-interacting C-termini of DSCAM and DSCAML1 for function, indicating multiple intracellular molecular mechanisms are involved. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 4, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 15, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 15, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 15, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 15, "disease_count": 4, "glyco_site_count": 22, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030424 axon;GO:0045202 synapse;GO:0016020 membrane", "go_biological_process": "GO:0007162 negative regulation of cell adhesion;GO:0007417 central nervous system development;GO:0007420 brain development;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0048704 embryonic skeletal system morphogenesis", "synthesized_glycan_count": 0, "hit_score": 4.2, "record_id": "Q4VA61-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q401-1", "uniprot_id": [ { "id": "RYR2_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q401", "type": "external" } ], "mass": 564819.0, "length": 4966, "protein_name": "Ryanodine receptor 2", "gene_name": "Ryr2", "organism": "Mouse", "refseq_name": "ryanodine receptor 2", "refseq_ac": [ { "id": "NP_076357", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076357", "type": "external" } ], "gene_names_uniprotkb": "Ryr2", "gene_names_refseq": "9330127I20Rik; RYR-2; Ryr2", "protein_names_uniprotkb": "Ryanodine receptor 2; Cardiac muscle ryanodine receptor-calcium release channel; Cardiac muscle ryanodine receptor; RYR-2; RyR2; Type 2 ryanodine receptor", "protein_names_refseq": "calcium release channel; cardiac muscle ryanodine receptor-calcium release channel; cardiac muscle ryanodine receptor; ryanodine receptor 2; ryanodine receptor type 2; type 2 ryanodine receptor", "tax_id": 10090, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); catecholaminergic polymorphic ventricular tachycardia 1 (Disease Ontology:DOID:0060675); pre-eclampsia (Disease Ontology:DOID:10591); heart disease (Disease Ontology:DOID:114); gestational diabetes (Disease Ontology:DOID:11714); alcohol use disorder (Disease Ontology:DOID:1574); congenital myopathy 1A (Disease Ontology:DOID:3529); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); malignant hyperthermia (Disease Ontology:DOID:8545)", "pathway": " (mmu:20191); (R-MMU-2672351); (R-MMU-5578775)", "pathway_count": 3, "publication_count": 27, "publication_id_list": "10.1101/2023.09.13.557529;10473538;17404231;17693412;19913485;20214899;20431056;21098440;21183079;21645850;21750661;22705209;23978697;25428506;26245150;27669760;28740084;30541771;33300544;33536282;34418053;37507081;38385988;38444585;7621815;7876312;9628868", "class_list": "", "function": "Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) cytosolic levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Phosphorylation of RyR2 simultaneously expands the dyad and rearranges the tetramers., [RefSeq, PubMed]; Whole-exome sequencing in familial type 2 diabetes identifies an atypical missense variant in the RyR2 gene. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 12, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 10, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "O70181;Q62174;Q62197;Q9ERN6", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0034236 protein kinase A catalytic subunit binding;GO:0005262 calcium channel activity;GO:0005516 calmodulin binding;GO:0019899 enzyme binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005790 smooth endoplasmic reticulum;GO:0016020 membrane;GO:0031234 extrinsic component of cytoplasmic side of plasma membrane;GO:0030017 sarcomere", "go_biological_process": "GO:0051284 positive regulation of sequestering of calcium ion;GO:0019722 calcium-mediated signaling;GO:0051592 response to calcium ion;GO:0051775 response to redox state;GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "E9Q401-1", "record_type": "protein", "filter_code": "0000000.1100111.000100.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62420-1", "uniprot_id": [ { "id": "SH3G2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62420", "type": "external" } ], "mass": 39955.0, "length": 352, "protein_name": "Endophilin-A1", "gene_name": "Sh3gl2", "organism": "Mouse", "refseq_name": "endophilin-A1 isoform 1", "refseq_ac": [ { "id": "NP_062408", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062408", "type": "external" } ], "gene_names_uniprotkb": "Sh3gl2; Een1; Sh3d2a", "gene_names_refseq": "9530001L19Rik; B930049H17Rik; EEN-B1; EEN1; SH3PA; Sh3d2a; Sh3gl2", "protein_names_uniprotkb": "Endophilin-A1; Endophilin-1; SH3 domain protein 2A; SH3 domain-containing GRB2-like protein 2; SH3p4", "protein_names_refseq": "SH3 domain protein 2A; SH3 domain-containing GRB2-like protein 2; SH3p4; endophilin I; endophilin-1; endophilin-A1 isoform 1; endophilin-A1", "tax_id": 10090, "disease": "", "pathway": " (mmu:20404); (R-MMU-177504); (R-MMU-182971); (R-MMU-2132295); (R-MMU-432720); (R-MMU-432722); (R-MMU-437239); (R-MMU-6807004); (R-MMU-8856825); (R-MMU-8856828)", "pathway_count": 10, "publication_count": 13, "publication_id_list": "10490020;10531379;11978849;16023669;18602463;19481455;21183079;21750661;21849472;28891236;29953872;37837716;9630982", "class_list": "", "function": "Implicated in endocytosis (PubMed:10490020, PubMed:21849472, PubMed:29953872). Involved ultrafast endocytosis, by mediating, in a first step, neck formation and in a second step, aids in the removal of clathrin coats from the regenerated vesicles (PubMed:29953872). May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth (PubMed:21849472). Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes (PubMed:21849472)., [UniProtKB, PubMed, PubMed, PubMed]; The role of EndophilinA1 in chronic unpredicted mild stress-induced depression model mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UTL7;Q3UY49;Q8BXS6;Q8VBV1", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0044325 transmembrane transporter binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005769 early endosome;GO:0005829 cytosol;GO:0016020 membrane;GO:0045202 synapse", "go_biological_process": "GO:0097749 membrane tubulation;GO:1990416 cellular response to brain-derived neurotrophic factor stimulus;GO:0097753 membrane bending;GO:0010629 negative regulation of gene expression;GO:0031175 neuron projection development", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q62420-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97789-1", "uniprot_id": [ { "id": "XRN1_MOUSE", "url": "https://www.uniprot.org/uniprot/P97789", "type": "external" } ], "mass": 194307.0, "length": 1719, "protein_name": "5'-3' exoribonuclease 1", "gene_name": "Xrn1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Xrn1; Dhm2; Exo; Sep1", "gene_names_refseq": "", "protein_names_uniprotkb": "5'-3' exoribonuclease 1; 3.1.13.-; Protein Dhm2; Strand-exchange protein 1 homolog; mXRN1", "protein_names_refseq": "", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (mmu:24127); (R-MMU-450385); (R-MMU-450513)", "pathway_count": 3, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;14580940;19144319;21750661;22517741;25428506;25605945;26495903;29033321;30059200;30084848;30779550;32782141;32848054;34428180;40885482;9049243;9218715", "class_list": "", "function": "Major 5'-3' exoribonuclease involved in mRNA decay (By similarity). Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates (PubMed:9049243). The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex (PubMed:9049243). Plays a role in replication-dependent histone mRNA degradation (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 11, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 11, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 11, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "O35651;P97790;Q3TE44;Q3TRE9;Q3UQL5", "ec_number_list": [ { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "3.6.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.62", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0002151 G-quadruplex RNA binding;GO:0051880 G-quadruplex DNA binding;GO:0004534 5'-3' RNA exonuclease activity;GO:0070034 telomerase RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0071028 nuclear mRNA surveillance;GO:0006396 RNA processing;GO:0000723 telomere maintenance;GO:0017148 negative regulation of translation;GO:0006402 mRNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "P97789-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DBH0-1", "uniprot_id": [ { "id": "WWP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DBH0", "type": "external" } ], "mass": 98761.0, "length": 870, "protein_name": "NEDD4-like E3 ubiquitin-protein ligase WWP2", "gene_name": "Wwp2", "organism": "Mouse", "refseq_name": "NEDD4-like E3 ubiquitin-protein ligase WWP2", "refseq_ac": [ { "id": "NP_080106", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080106", "type": "external" } ], "gene_names_uniprotkb": "Wwp2", "gene_names_refseq": "1300010O06Rik; AIP2; Wwp2", "protein_names_uniprotkb": "NEDD4-like E3 ubiquitin-protein ligase WWP2; 2.3.2.26; HECT-type E3 ubiquitin transferase WWP2; WW domain-containing protein 2", "protein_names_refseq": "HECT-type E3 ubiquitin transferase WWP2; NEDD4-like E3 ubiquitin-protein ligase WWP2; WW domain-containing protein 2; WW domain-containing protein 4", "tax_id": 10090, "disease": "Liddle syndrome (Disease Ontology:DOID:0050477)", "pathway": " (mmu:66894); (R-MMU-8948751); (R-MMU-9013406); (R-MMU-9013420); (R-MMU-9013507)", "pathway_count": 5, "publication_count": 14, "publication_id_list": "16075062;17526739;18776082;19651900;19997087;21750661;25428506;26495903;26740625;28011936;29187734;31599954;37828378;38166045", "class_list": "", "function": "E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; regulates POU5F1 protein level during differentiation of embryonal carcinoma cells (ECCs) but not in undifferentiated ECCs and embryonic stem cells (ESCs). Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Proliferation, migration and phenotypic transformation of VSMC induced via Hcy related to up-expression of WWP2 and p-STAT3. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BTG4;Q923F6", "ec_number_list": [ { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "1.16.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.1.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" } ], "go_molecular_function": "GO:0019870 potassium channel inhibitor activity;GO:0044325 transmembrane transporter binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:1903765 negative regulation of potassium ion export across plasma membrane;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0010629 negative regulation of gene expression;GO:0042391 regulation of membrane potential;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9DBH0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C0R7-1", "uniprot_id": [ { "id": "ZMY15_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C0R7", "type": "external" } ], "mass": 81604.0, "length": 736, "protein_name": "Zinc finger MYND domain-containing protein 15", "gene_name": "Zmynd15", "organism": "Mouse", "refseq_name": "zinc finger MYND domain-containing protein 15 isoform 1", "refseq_ac": [ { "id": "NP_001025100", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025100", "type": "external" } ], "gene_names_uniprotkb": "Zmynd15", "gene_names_refseq": "Zmynd15", "protein_names_uniprotkb": "Zinc finger MYND domain-containing protein 15", "protein_names_refseq": "zinc finger MYND domain-containing protein 15 isoform 1; zinc finger MYND domain-containing protein 15", "tax_id": 10090, "disease": "spermatogenic failure 14 (Disease Ontology:DOID:0070179)", "pathway": " (mmu:574428)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "20675388;21750661", "class_list": "", "function": "Acts as a transcriptional repressor through interaction with histone deacetylases (HDACs). May regulate haploid genes important for spermiogenesis., [UniProtKB, PubMed]; ZMYND15 represents the first transcriptional repressor identified to be essential for sperm production and male fertility., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TAD1", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042826 histone deacetylase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0007286 spermatid development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8C0R7-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D856-1", "uniprot_id": [ { "id": "S39A5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D856", "type": "external" } ], "mass": 56275.0, "length": 535, "protein_name": "Zinc transporter ZIP5", "gene_name": "Slc39a5", "organism": "Mouse", "refseq_name": "zinc transporter ZIP5 precursor", "refseq_ac": [ { "id": "NP_001129709", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129709", "type": "external" } ], "gene_names_uniprotkb": "Slc39a5; Zip5", "gene_names_refseq": "1810013D05Rik; 2010205A06Rik; Slc39a5; Zip5", "protein_names_uniprotkb": "Zinc transporter ZIP5; Solute carrier family 39 member 5; ZIP-5; Zrt- and Irt-like protein 5", "protein_names_refseq": "ZIP-5; solute carrier family 39 member 5; zinc transporter ZIP5 precursor; zinc transporter ZIP5; zrt- and Irt-like protein 5", "tax_id": 10090, "disease": "myopia (Disease Ontology:DOID:11830)", "pathway": " (mmu:72002)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "15322118;15358787;16682017;18020946;21183079;21750661;24039764;24303081;24891338;30324491;34252710;36583994", "class_list": "", "function": "SLC39A5 promotes lung adenocarcinoma cell proliferation by activating PI3K/AKT signaling., [RefSeq, PubMed]; Temporal and spatial patterns of expression of the mouse ZIP1, 3, 4, and 5 genes in the developing intestine and the effects of maternal dietary zinc deficiency on these patterns of expression were examined, [RefSeq, PubMed]; The authors show that Slc39a5-mediated zinc influx induces expression of Glut2 (Glucose Transporter Type 2) via Sirt1 (sirtuin 1)-mediated Pgc-1alpha (peroxisome proliferative activated receptor, gamma, coactivator 1 alpha) activation., [RefSeq, PubMed]; Uniporter that transports zinc(2+) into polarized cells of enterocytes, pancreatic acinar and endoderm cells across the basolateral membrane and participates, notably, in zinc excretion from the intestine by the uptake of zinc from the blood into the intestine (PubMed:15322118, PubMed:24303081). The transport mechanism is temperature- and concentration-dependent and saturable (PubMed:15322118). In addition, is also a high affinity copper transporter in vitro (By similarity). Also may regulate glucose-stimulated insulin secretion (GSIS) in islets primarily through the zinc-activated SIRT1-PPARGC1A axis (PubMed:30324491). Could regulate the BMP/TGF-beta (bone morphogenetic protein/transforming growth factor-beta) signaling pathway and modulates extracellular matrix (ECM) proteins of the sclera (By similarity). Plays a role in eye development (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; ZIP4 and ZIP5 have roles in the adaptive response to dietary zinc in mice [ZIP5], [RefSeq, PubMed]; Zip5 protein is a zinc transporter that localizes to the basolateral surface of polarized cells, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9D909", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0140410 monoatomic cation:bicarbonate symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0048026 positive regulation of mRNA splicing, via spliceosome;GO:0071577 zinc ion transmembrane transport;GO:0006829 zinc ion transport;GO:0030509 BMP signaling pathway;GO:0006882 intracellular zinc ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9D856-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07279-1", "uniprot_id": [ { "id": "NFE2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q07279", "type": "external" } ], "mass": 41565.0, "length": 373, "protein_name": "Transcription factor NF-E2 45 kDa subunit", "gene_name": "Nfe2", "organism": "Mouse", "refseq_name": "transcription factor NF-E2 45 kDa subunit", "refseq_ac": [ { "id": "NP_001289267", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289267", "type": "external" } ], "gene_names_uniprotkb": "Nfe2", "gene_names_refseq": "NF-E2/P45; NF-E2; Nfe2; p45NFE2; p45nf-e2; p45", "protein_names_uniprotkb": "Transcription factor NF-E2 45 kDa subunit; Leucine zipper protein NF-E2; Nuclear factor, erythroid-derived 2 45 kDa subunit; p45 NF-E2", "protein_names_refseq": "leucine zipper protein NF-E2; nuclear factor, erythroid derived 2, 45 kDa; nuclear factor, erythroid-derived 2 45 kDa subunit; transcription factor NF-E2 45 kDa subunit", "tax_id": 10090, "disease": "", "pathway": " (mmu:18022); (R-MMU-983231)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "14597626;16287851;17707229;19966288;21750661;29476075;30755419;36709354;8469283;9171106;9558374", "class_list": "", "function": "Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron., [UniProtKB, PubMed]; Mutations in NFE2 predispose to the acquisition of secondary changes promoting the development of myelosarcoma and/or AML, [RefSeq, PubMed]; The histone demethylase JMJD2C constitutes a novel NFE2 target gene that is required for the survival of JAK2[V617F] mutated cells., [RefSeq, PubMed]; We detected that cigarette smoke significantly increased p45 NFE2 levels in DJ-1 KO mice compared to wild-type mice. Our results indicate that p45 NFE2 expression is induced by exposure to cigarette smoke, has a cytoprotective activity against cell injury, and its downregulation in human primary ATII cells may contribute to emphysema pathogenesis Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P6K5", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0042802 identical protein binding;GO:0050699 WW domain binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016605 PML body;GO:0032993 protein-DNA complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007267 cell-cell signaling;GO:0008285 negative regulation of cell population proliferation;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q07279-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZD4-1", "uniprot_id": [ { "id": "XPF_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QZD4", "type": "external" } ], "mass": 103690.0, "length": 917, "protein_name": "DNA repair endonuclease XPF", "gene_name": "Ercc4", "organism": "Mouse", "refseq_name": "DNA repair endonuclease XPF", "refseq_ac": [ { "id": "NP_056584", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056584", "type": "external" } ], "gene_names_uniprotkb": "Ercc4; Xpf", "gene_names_refseq": "Ercc4; Xpf", "protein_names_uniprotkb": "DNA repair endonuclease XPF; 3.1.-.-; DNA excision repair protein ERCC-4", "protein_names_refseq": "DNA excision repair protein ERCC-4; DNA repair endonuclease XPF; DNA repair endonuclease subunit", "tax_id": 10090, "disease": "xeroderma pigmentosum (Disease Ontology:DOID:0050427); XFE progeroid syndrome (Disease Ontology:DOID:0060590); xeroderma pigmentosum group A (Disease Ontology:DOID:0110843); xeroderma pigmentosum group F (Disease Ontology:DOID:0110848); Fanconi anemia complementation group Q (Disease Ontology:DOID:0111093); Fanconi anemia (Disease Ontology:DOID:13636); polyneuropathy due to drug (Disease Ontology:DOID:14184); cancer (Disease Ontology:DOID:162); pancreatic cancer (Disease Ontology:DOID:1793); Cockayne syndrome (Disease Ontology:DOID:2962); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:50505); (R-MMU-5685938); (R-MMU-5696395); (R-MMU-5696400); (R-MMU-6782135); (R-MMU-6783310)", "pathway_count": 6, "publication_count": 13, "publication_id_list": "10644440;14690602;15199134;21183079;21750661;21952136;25428506;25538220;28368372;30084848;30779550;34428180;35941380", "class_list": "", "function": "Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair, and which is essential for nucleotide excision repair (NER) and interstrand cross-link (ICL) repair., [UniProtKB, UniProtKB]; Data reveal an unanticipated involvement of the ERCC1/XPF NER endonuclease in the regulation of telomere integrity., [RefSeq, PubMed]; ERCC1-XPF cooperates with CTCF and cohesin to facilitate the developmental silencing of imprinted genes and that persistent DNA damage triggers chromatin changes that affect gene expression programs associated with NER disorders. Erratum:[Nat Cell Biol. 2025 Dec;27(12):2240. doi: 10.1038/s41556-025-01791-x. PMID: 41028839], [RefSeq, PubMed]; Mitomycin C triggered sister chromatid exchanges in wild-type cells but chromatid fusions in Ercc1(-/-) and Xpf mutant cells, indicating that in their absence, repair of double-strand breaks(DSBs)is prevented., [RefSeq, PubMed]; The structure-specific endonuclease complex SLX4-XPF regulates Tus-Ter-induced homologous recombination., [RefSeq, PubMed]; These results establish USP45 as a new regulator of XPF-ERCC1 crucial for efficient DNA repair, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O54810;Q8R0I3", "ec_number_list": [ { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "3.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.5.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.6", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.22.-", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.1.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.2", "type": "external" } ], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0003684 damaged DNA binding;GO:0004520 DNA endonuclease activity;GO:0001094 TFIID-class transcription factor complex binding", "go_cellular_component": "GO:0000110 nucleotide-excision repair factor 1 complex;GO:0070522 ERCC4-ERCC1 complex;GO:0000109 nucleotide-excision repair complex;GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0000712 resolution of meiotic recombination intermediates;GO:0032205 negative regulation of telomere maintenance;GO:0061819 telomeric DNA-containing double minutes formation;GO:1905765 negative regulation of protection from non-homologous end joining at telomere;GO:0006281 DNA repair", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9QZD4-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JIY5-1", "uniprot_id": [ { "id": "HTRA2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JIY5", "type": "external" } ], "mass": 49348.0, "length": 458, "protein_name": "Serine protease HTRA2, mitochondrial", "gene_name": "Htra2", "organism": "Mouse", "refseq_name": "serine protease HTRA2, mitochondrial", "refseq_ac": [ { "id": "NP_062726", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062726", "type": "external" } ], "gene_names_uniprotkb": "Htra2; Omi; Prss25", "gene_names_refseq": "Htra2; Omi; Prss25; mnd2", "protein_names_uniprotkb": "Serine protease HTRA2, mitochondrial; 3.4.21.108; High temperature requirement protein A2; HtrA2; Omi stress-regulated endoprotease; Serine protease 25; Serine proteinase OMI", "protein_names_refseq": "high temperature requirement protein A2; motor neuron degeneration 2; omi stress-regulated endoprotease; protease, serine, 25; serine protease 25; serine protease HTRA2, mitochondrial; serine protease OMI; serine proteinase OMI", "tax_id": 10090, "disease": "3-methylglutaconic aciduria type 8 (Disease Ontology:DOID:0070000); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); asphyxia neonatorum (Disease Ontology:DOID:11088); cryptorchidism (Disease Ontology:DOID:11383); endometrial cancer (Disease Ontology:DOID:1380); Parkinson's disease (Disease Ontology:DOID:14330); status epilepticus (Disease Ontology:DOID:1824); transient cerebral ischemia (Disease Ontology:DOID:224); motor neuron disease (Disease Ontology:DOID:231); ovarian cancer (Disease Ontology:DOID:2394); middle cerebral artery infarction (Disease Ontology:DOID:3525); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:64704); (R-MMU-9837999)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;10971580;11604410;21701498;21750661;23479728;34428180;35820727;36525924;36539842;38338855", "class_list": "", "function": "Delayed hair cycle in mnd2 mutant mice lacking HtrA2 serine protease activity., [RefSeq, PubMed]; HTRA2/OMI-Mediated Mitochondrial Quality Control Alters Macrophage Polarization Affecting Systemic Chronic Inflammation. Review article Publication Status: Online-Only, [RefSeq, PubMed]; Insufficient HtrA2 causes meiotic defects in aging germinal vesicle oocytes. Publication Status: Online-Only, [RefSeq, PubMed]; Serine protease that shows proteolytic activity against a non-specific substrate beta-casein (By similarity). Promotes apoptosis by either relieving the inhibition of BIRC proteins on caspases, leading to an increase in caspase activity; or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism (PubMed:11604410). Cleaves BIRC6 and relieves its inhibition on CASP3, CASP7 and CASP9, but it is also prone to inhibition by BIRC6 (By similarity). Cleaves THAP5 and promotes its degradation during apoptosis (By similarity)., [UniProtKB, UniProtKB, PubMed]; Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes apoptosis by either relieving the inhibition of BIRC proteins on caspases, leading to an increase in caspase activity; or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves BIRC6 and relieves its inhibition on CASP3, CASP7 and CASP9, but it is also prone to inhibition by BIRC6. Cleaves THAP5 and promotes its degradation during apoptosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 14, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9R108", "ec_number_list": [ { "id": "3.4.21.108", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.108", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0042802 identical protein binding;GO:0008233 peptidase activity;GO:1990948 ubiquitin ligase inhibitor activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:0006508 proteolysis;GO:0008344 adult locomotory behavior;GO:0030900 forebrain development;GO:0035556 intracellular signal transduction;GO:0040014 regulation of multicellular organism growth", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9JIY5-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08966-1", "uniprot_id": [ { "id": "S22A1_MOUSE", "url": "https://www.uniprot.org/uniprot/O08966", "type": "external" } ], "mass": 61521.0, "length": 556, "protein_name": "Solute carrier family 22 member 1", "gene_name": "Slc22a1", "organism": "Mouse", "refseq_name": "solute carrier family 22 member 1", "refseq_ac": [ { "id": "NP_033228", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033228", "type": "external" } ], "gene_names_uniprotkb": "Slc22a1; Lx1; Oct1", "gene_names_refseq": "Lx1; Oct1; Orct1; Orct; Slc22a1", "protein_names_uniprotkb": "Solute carrier family 22 member 1; Organic cation transporter 1; mOCT1", "protein_names_refseq": "mOCT1; organic cation transporter 1; solute carrier family 22 member 1; solute carrier family 22, member 1", "tax_id": 10090, "disease": "extrahepatic cholestasis (Disease Ontology:DOID:13619); intrahepatic cholestasis (Disease Ontology:DOID:1852); asthma (Disease Ontology:DOID:2841); acute kidney failure (Disease Ontology:DOID:3021)", "pathway": " (mmu:20517); (R-MMU-112311); (R-MMU-181430); (R-MMU-2161517); (R-MMU-442660); (R-MMU-549127); (R-MMU-9793528)", "pathway_count": 7, "publication_count": 17, "publication_id_list": "10216142;11463829;12176030;15458920;16381671;21183079;21750661;23458604;23680637;24961373;28942964;33790797;34040533;34428180;35469921;37511245;8854860", "class_list": "", "function": "Amino acids in transmembrane helix 1 confer major functional differences between human and mouse orthologs of the polyspecific membrane transporter OCT1., [RefSeq, PubMed]; Electrogenic voltage-dependent uniporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics (PubMed:10216142, PubMed:11463829, PubMed:12176030, PubMed:23458604, PubMed:24961373). Functions as a pH- and Na(+)-independent, bidirectional transporter (By similarity). Cation cellular uptake or release is driven by the electrochemical potential (i.e. membrane potential and concentration gradient) and substrate selectivity (By similarity). Hydrophobicity is a major requirement for recognition in polyvalent substrates and inhibitors (PubMed:23458604). Primarily expressed in the basolateral membrane of hepatocytes and proximal tubules and involved in the uptake and disposition of cationic compounds from the blood by hepatic and renal clearance (By similarity). Most likely functions as an uptake carrier in enterocytes contributing to the intestinal elimination of organic cations from the systemic circulation (PubMed:11463829, PubMed:24961373). Transports endogenous monoamines such as N-1-methylnicotinamide (NMN), guanidine, neurotransmitters dopamine, serotonin, noradrenaline, adrenaline and histamine, and quaternary ammonium compound such as choline (PubMed:24961373, PubMed:35469921). Also transports natural polyamines such as spermidine, agmatine and putrescine at low affinity, but relatively high turnover (PubMed:23458604). Involved in the hepatic and intestinal uptake of the vitamin B1/thiamine, hence regulating hepatic lipid and energy metabolism (PubMed:24961373). Contributes to the influx and efflux of fatty acid carriers carnitines and acylcarnitines across the basolateral membrane of hepatocytes, from the liver to the systemic circulation and inversely and may be involved in regulating the systemic availability of hepatic acylcarnitines (PubMed:28942964, PubMed:34040533). Also capable of transporting non-amine endogenous compounds such as prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) (By similarity). May contribute to the transport of cationic compounds in testes across the blood-testis-barrier (By similarity). Also mediates the uptake of xenobiotics tributylmethylammonium (TBuMA), quinidine, N-methyl-quinine (NMQ), N-methyl-quinidine (NMQD) N-(4,4-azo-n-pentyl)-quinuclidine (APQ), azidoprocainamide methoiodide (AMP), N-(4,4-azo-n-pentyl)-21-deoxyajmalinium (APDA) and 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP) (PubMed:11463829)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Role of Mouse Organic Cation Transporter 2 for Nephro- and Peripheral Neurotoxicity Induced by Chemotherapeutic Treatment with Cisplatin. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9R1Q4", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005326 neurotransmitter transmembrane transporter activity;GO:0015651 quaternary ammonium group transmembrane transporter activity;GO:0042910 xenobiotic transmembrane transporter activity;GO:0005334 norepinephrine:sodium symporter activity;GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0016328 lateral plasma membrane;GO:0009925 basal plasma membrane", "go_biological_process": "GO:0015697 quaternary ammonium group transport;GO:0015844 monoamine transport;GO:0015870 acetylcholine transport;GO:0072237 metanephric proximal tubule development;GO:0015695 organic cation transport", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "O08966-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62188-1", "uniprot_id": [ { "id": "DPYL3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62188", "type": "external" } ], "mass": 61936.0, "length": 570, "protein_name": "Dihydropyrimidinase-related protein 3", "gene_name": "Dpysl3", "organism": "Mouse", "refseq_name": "dihydropyrimidinase-related protein 3 isoform CRMP4a", "refseq_ac": [ { "id": "NP_033494", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033494", "type": "external" } ], "gene_names_uniprotkb": "Dpysl3; Drp3; Ulip", "gene_names_refseq": "CRMP-4; DRP-3; Dpysl3; TUC4; ULIP-1; Ulip1; Ulip", "protein_names_uniprotkb": "Dihydropyrimidinase-related protein 3; DRP-3; ULIP-1; Unc-33-like phosphoprotein 1", "protein_names_refseq": "collapsin response mediator protein 4; dihydropyrimidinase-related protein 3 isoform CRMP4a; dihydropyrimidinase-related protein 3; unc-33-like phosphoprotein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:22240); (R-MMU-399956)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "10956643;14685275;15345747;18034455;19131326;21183079;21750661;23568759;25652774;30084848;31599954;34190355;34428180;34860155;35093877;35820727;37507081;37828378;38914219;8551352", "class_list": "", "function": "A CRMP4-dependent retrograde axon-to-soma death signal in amyotrophic lateral sclerosis., [RefSeq, PubMed]; CRMP4 Up-regulates M2 Macrophages and Myeloid-derived Suppressor Cells to Promote Pancreatic Cancer in Mice., [RefSeq, PubMed]; CRMP4-mediated fornix development involves Semaphorin-3E signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; In the human ortholog of Dpysl3, the association between the rs147541241 variant and amyotrophic lateral sclerosis was limited to the French population., [RefSeq, PubMed]; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The role of CRMP4 in LPS-induced neuroinflammation., [RefSeq, PubMed]; This gene encodes a protein that belongs to the TUC (TOAD-64/Ulip/CRMP) family of proteins. Members of this family are phosphoproteins that function in axonal guidance and neuronal differentiation during development and regeneration of the nervous system. A mutation in the human gene is associated with amyotrophic lateral sclerosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0042802 identical protein binding;GO:0051219 phosphoprotein binding;GO:0035374 chondroitin sulfate binding;GO:0031005 filamin binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol;GO:0030027 lamellipodium;GO:0030426 growth cone;GO:0045202 synapse", "go_biological_process": "GO:0007399 nervous system development;GO:0010976 positive regulation of neuron projection development;GO:0030336 negative regulation of cell migration;GO:0010977 negative regulation of neuron projection development;GO:0051017 actin filament bundle assembly", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q62188-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91XQ0-1", "uniprot_id": [ { "id": "DYH8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91XQ0", "type": "external" } ], "mass": 541238.0, "length": 4731, "protein_name": "Dynein axonemal heavy chain 8", "gene_name": "Dnah8", "organism": "Mouse", "refseq_name": "dynein axonemal heavy chain 8", "refseq_ac": [ { "id": "NP_038839", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038839", "type": "external" } ], "gene_names_uniprotkb": "Dnah8; Dnahc8", "gene_names_refseq": "ATPase; Dnah8; Dnahc8; Hst6.7b; P1-Loop", "protein_names_uniprotkb": "Dynein axonemal heavy chain 8; Axonemal beta dynein heavy chain 8; Ciliary dynein heavy chain 8", "protein_names_refseq": "axonemal beta dynein heavy chain 8; axonemal dynein heavy chain 8 Dnahc8; ciliary dynein heavy chain 8; dynein axonemal heavy chain 8; dynein heavy chain 8, axonemal; dynein, axon, heavy chain 8", "tax_id": 10090, "disease": "spermatogenic failure 46 (Disease Ontology:DOID:0112164); sensorineural hearing loss (Disease Ontology:DOID:10003); pre-eclampsia (Disease Ontology:DOID:10591); gestational diabetes (Disease Ontology:DOID:11714)", "pathway": " (mmu:13417)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10602986;12297094;16054618;20173027;20653129;21750661;21913724;25428506;27802388;30084848;30779550;32619401;37014212;40885482;9373155", "class_list": "", "function": "Bi-allelic DNAH8 Variants Lead to Multiple Morphological Abnormalities of the Sperm Flagella and Primary Male Infertility., [RefSeq, PubMed]; Cocaine could inhibit the activities of ATPase, LDH and SDH in cultured splenocytes., [RefSeq, PubMed]; Copper Efflux System Required in Murine Lung Infection by Haemophilus influenzae Composed of a Canonical ATPase Gene and Tandem Chaperone Gene Copies., [RefSeq, PubMed]; Force generating protein component of the outer dynein arms (ODAs) in the sperm flagellum (PubMed:10602986, PubMed:12297094, PubMed:32619401). Produces force towards the minus ends of microtubules (PubMed:32619401). Key component of dynein, a family of motor proteins essential for movement along microtubules (By similarity). Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (PubMed:32619401). Involved in sperm motility; implicated in sperm flagellar assembly (PubMed:32619401)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; T complex distorter 2 candidate gene, Dnahc8, encodes at least two testis-specific axonemal dynein heavy chains that differ extensively at their amino and carboxyl termini, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9Q010;O08830;Q3V0D2;Q91V63;Q91XP8;Q91XP9;Q99MH8;Q9QY72", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0003777 microtubule motor activity;GO:0008569 minus-end-directed microtubule motor activity;GO:0051959 dynein light intermediate chain binding;GO:0045505 dynein intermediate chain binding", "go_cellular_component": "GO:0005874 microtubule;GO:0036126 sperm flagellum;GO:0005930 axoneme;GO:0097228 sperm principal piece;GO:0097225 sperm midpiece", "go_biological_process": "GO:0060294 cilium movement involved in cell motility;GO:0036158 outer dynein arm assembly;GO:0007018 microtubule-based movement", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q91XQ0-1", "record_type": "protein", "filter_code": "0000000.1000111.000100.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52293-1", "uniprot_id": [ { "id": "IMA1_MOUSE", "url": "https://www.uniprot.org/uniprot/P52293", "type": "external" } ], "mass": 57928.0, "length": 529, "protein_name": "Importin subunit alpha-1", "gene_name": "Kpna2", "organism": "Mouse", "refseq_name": "importin subunit alpha-1", "refseq_ac": [ { "id": "NP_034785", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034785", "type": "external" } ], "gene_names_uniprotkb": "Kpna2; Rch1", "gene_names_refseq": "2410044B12Rik; IPOA1; Kpna2; PTAC58; Rch1", "protein_names_uniprotkb": "Importin subunit alpha-1; Importin alpha P1; Karyopherin subunit alpha-2; PTAC58; Pendulin; Pore targeting complex 58 kDa subunit; RAG cohort protein 1; SRP1-alpha", "protein_names_refseq": "RAG cohort protein 1; SRP1-alpha; importin alpha 1; importin alpha P1; importin subunit alpha-1; importin subunit alpha-2; karyopherin (importin) alpha 2; m-importin-alpha-P1; pendulin; pore targeting complex 58 kDa subunit", "tax_id": 10090, "disease": "", "pathway": " (mmu:16647); (R-MMU-5693548)", "pathway_count": 2, "publication_count": 26, "publication_id_list": "10201409;10692581;10764582;11448961;16222336;21183079;21454664;21690087;21750661;22645316;22872234;26689472;29187734;31219806;34203471;34428180;34887587;35820727;36210013;37792911;38656660;39423201;39627609;7565597;7641681;8631802", "class_list": "", "function": "Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1 (PubMed:21690087). Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (PubMed:21690087). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediator of PR-DUB complex component BAP1 nuclear import; acts redundantly with KPNA1 and Transportin-1/TNPO1 (By similarity)., [UniProtKB, UniProtKB, PubMed]; Karyopherin alpha2 is a maternal effect gene required for early embryonic development and female fertility in mice., [RefSeq, PubMed]; Normal male fertility in a mouse model of KPNA2 deficiency. Publication Status: Online-Only, [RefSeq, PubMed]; Nuclear ERK1/2 signaling potentiation enhances neuroprotection and cognition via Importinalpha1/KPNA2., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q64292", "ec_number_list": [], "go_molecular_function": "GO:0042826 histone deacetylase binding;GO:0008139 nuclear localization sequence binding;GO:0061608 nuclear import signal receptor activity;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0045893 positive regulation of DNA-templated transcription;GO:0038061 non-canonical NF-kappaB signal transduction;GO:0032481 positive regulation of type I interferon production;GO:1903902 positive regulation of viral life cycle;GO:0006607 NLS-bearing protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P52293-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70257-3", "uniprot_id": [ { "id": "NFIX_MOUSE", "url": "https://www.uniprot.org/uniprot/P70257", "type": "external" } ], "mass": 53394.0, "length": 488, "protein_name": "Nuclear factor 1 X-type", "gene_name": "Nfix", "organism": "Mouse", "refseq_name": "nuclear factor 1 X-type isoform 1", "refseq_ac": [ { "id": "NP_001075451", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075451", "type": "external" } ], "gene_names_uniprotkb": "Nfix", "gene_names_refseq": "CTF; NF-I/X; NF1-X; NFI-X; Nfix", "protein_names_uniprotkb": "Nuclear factor 1 X-type; CCAAT-box-binding transcription factor; CTF; NF-I/X; NF1-X; NFI-X; Nuclear factor 1/X; Nuclear factor I/X; TGGCA-binding protein", "protein_names_refseq": "CCAAT-box-binding transcription factor; TGGCA-binding protein; nuclear factor 1 X-type isoform 1; nuclear factor 1 X-type; nuclear factor 1/X", "tax_id": 10090, "disease": "Marshall-Smith syndrome (Disease Ontology:DOID:0050858); Sotos syndrome 2 (Disease Ontology:DOID:0112102); Scheuermann's disease (Disease Ontology:DOID:13300)", "pathway": " (mmu:18032)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10087299;12568726;15345747;17242355;21183079;22645316;24129315;25428506;30084848;30779550;32848054;34203471;34428180;35820727;37453647;40885482;8581067;9056636", "class_list": "", "function": "Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. Isoform NFIX1 acts as a transcriptional activator while isoform NFIX3 acts as a repressor., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "O08519;P70258;Q64192;Q99L78;Q9R1G2", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0014016 neuroblast differentiation;GO:0043403 skeletal muscle tissue regeneration;GO:0030316 osteoclast differentiation;GO:0014816 skeletal muscle satellite cell differentiation;GO:0060429 epithelium development", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P70257-3", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O89050-1", "uniprot_id": [ { "id": "MKLN1_MOUSE", "url": "https://www.uniprot.org/uniprot/O89050", "type": "external" } ], "mass": 84878.0, "length": 735, "protein_name": "Muskelin", "gene_name": "Mkln1", "organism": "Mouse", "refseq_name": "muskelin isoform 1", "refseq_ac": [ { "id": "NP_038819", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038819", "type": "external" } ], "gene_names_uniprotkb": "Mkln1", "gene_names_refseq": "A130067F06Rik; Mkln1", "protein_names_uniprotkb": "Muskelin", "protein_names_refseq": "muskelin isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:27418); (R-MMU-9861718)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "18710924;21482357;21586270;21750661;25372678;25428506;30084848;30779550;31219806;34428180;36210013;38460002;9724633", "class_list": "", "function": "Circular RNA MKLN1 promotes epithelial-mesenchymal transition in pulmonary fibrosis by regulating the miR-26a/b-5p/CDK8 axis in human alveolar epithelial cells and mice models., [RefSeq, PubMed]; Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (By similarity). Required for internalization of the GABA receptor GABRA1 from the cell membrane via endosomes and subsequent GABRA1 degradation (PubMed:21482357). Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1 (PubMed:18710924, PubMed:9724633)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; The first crystal structure of mouse muskelin discoidin domain (MK-DD) is reported at 1.55 A resolution, which reveals a distorted eight-stranded beta-barrel with two short alpha-helices at one end of the barrel., [RefSeq, PubMed]; This novel interaction between TBX20b and MKLN1 may help elucidate new regulatory mechanisms within heart development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005938 cell cortex", "go_biological_process": "GO:0007160 cell-matrix adhesion;GO:0030036 actin cytoskeleton organization;GO:0008360 regulation of cell shape;GO:0002090 regulation of receptor internalization;GO:0098968 neurotransmitter receptor transport postsynaptic membrane to endosome", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "O89050-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62504-1", "uniprot_id": [ { "id": "MINT_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62504", "type": "external" } ], "mass": 398754.0, "length": 3644, "protein_name": "Msx2-interacting protein", "gene_name": "Spen", "organism": "Mouse", "refseq_name": "msx2-interacting protein isoform 1", "refseq_ac": [ { "id": "NP_062737", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062737", "type": "external" } ], "gene_names_uniprotkb": "Spen; Kiaa0929; Mint; Sharp", "gene_names_refseq": "Mint; Spen; mKIAA0929", "protein_names_uniprotkb": "Msx2-interacting protein; SMART/HDAC1-associated repressor protein; SPEN homolog", "protein_names_refseq": "Msx2 interacting nuclear target protein; SMART/HDAC1-associated repressor protein; SPEN homolog, transcriptional regulator; msx2-interacting protein isoform 1; msx2-interacting protein", "tax_id": 10090, "disease": "esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (mmu:56381); (R-MMU-9013422)", "pathway_count": 2, "publication_count": 33, "publication_id_list": "10.1101/2023.09.13.557529;10.3389/fragi.2021.757801;10451362;12374742;12594956;15131132;17242355;20484411;21183079;21606357;21750661;22517741;22645316;25428506;26192747;30084848;31219806;32379046;32848054;32986830;34112668;34418053;34428180;34853312;35820727;35822049;36577249;36852467;39627609;40021952;40885482;40997131;9119401", "class_list": "", "function": "Elements at the 5' end of Xist harbor SPEN-independent transcriptional antiterminator activity., [RefSeq, PubMed]; May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways, such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; RNA-binding protein SPEN controls hepatocyte maturation via regulating Hnf4alpha expression during liver development., [RefSeq, PubMed]; SPEN is required for Xist upregulation during initiation of X chromosome inactivation. Publication Status: Online-Only, [RefSeq, PubMed]; Spen links RNA-mediated endogenous retrovirus silencing and X chromosome inactivation. Publication Status: Online-Only, [RefSeq, PubMed]; Time-resolved structured illumination microscopy reveals key principles of Xist RNA spreading., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 16, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 16, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 16, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 45, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 22, "binding_glycan_count": 0, "secondary_ac_list": "Q80TN9;Q99PS4;Q9QZW2", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0003729 mRNA binding;GO:0003714 transcription corepressor activity;GO:0003697 single-stranded DNA binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0017053 transcription repressor complex", "go_biological_process": "GO:0060816 random inactivation of X chromosome;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007219 Notch signaling pathway", "synthesized_glycan_count": 0, "hit_score": 5.5, "record_id": "Q62504-1", "record_type": "protein", "filter_code": "0000000.0000111.001000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2L6-1", "uniprot_id": [ { "id": "MINP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z2L6", "type": "external" } ], "mass": 54537.0, "length": 481, "protein_name": "Multiple inositol polyphosphate phosphatase 1", "gene_name": "Minpp1", "organism": "Mouse", "refseq_name": "multiple inositol polyphosphate phosphatase 1 precursor", "refseq_ac": [ { "id": "NP_034929", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034929", "type": "external" } ], "gene_names_uniprotkb": "Minpp1; MNCb-1572; Mipp", "gene_names_refseq": "Minpp1", "protein_names_uniprotkb": "Multiple inositol polyphosphate phosphatase 1; 2,3-BPG phosphatase; 2,3-bisphosphoglycerate 3-phosphatase; 3.1.3.62; 3.1.3.80", "protein_names_refseq": "2,3-BPG phosphatase; 2,3-bisphosphoglycerate 3-phosphatase; inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase; ins(1,3,4,5)P(4) 3-phosphatase; multiple inositol polyphosphate phosphatase 1 precursor; multiple inositol polyphosphate phosphatase 1", "tax_id": 10090, "disease": "pontocerebellar hypoplasia type 16 (Disease Ontology:DOID:0112333); papillary thyroid carcinoma (Disease Ontology:DOID:3969)", "pathway": " (mmu:17330); (R-MMU-1855231)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;10087200;10938126;30899004;33257696", "class_list": "", "function": "MINPP1 prevents intracellular accumulation of the chelator inositol hexakisphosphate and is mutated in Pontocerebellar Hypoplasia. Publication Status: Online-Only, [RefSeq, PubMed]; Multiple inositol polyphosphate phosphatase that hydrolyzes 1D-myo-inositol 1,3,4,5,6-pentakisphosphate (InsP5[2OH]) and 1D-myo-inositol hexakisphosphate (InsP6) to a range of less phosphorylated inositol phosphates. This regulates the availability of these various small molecule second messengers and metal chelators which control many aspects of cell physiology (PubMed:10087200, PubMed:10938126). Has a weak in vitro activity towards 1D-myo-inositol 1,4,5-trisphosphate which is unlikely to be physiologically relevant. By regulating intracellular inositol polyphosphates pools, which act as metal chelators, it may control the availability of intracellular calcium and iron, which are important for proper neuronal development and homeostasis (PubMed:33257696). May have a dual substrate specificity, and function as a 2,3-bisphosphoglycerate 3-phosphatase hydrolyzing 2,3-bisphosphoglycerate to 2-phosphoglycerate. 2,3-bisphosphoglycerate (BPG) is formed as part of the Rapoport-Luebering glycolytic bypass and is a regulator of systemic oxygen homeostasis as the major allosteric effector of hemoglobin (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 8, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UA76;Q8VDR0;Q9JJD5", "ec_number_list": [ { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.62", "type": "external" }, { "id": "3.1.3.80", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.80", "type": "external" } ], "go_molecular_function": "GO:0003993 acid phosphatase activity;GO:0030351 inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity;GO:0034417 bisphosphoglycerate 3-phosphatase activity;GO:0052745 inositol phosphate phosphatase activity;GO:0016312 inositol bisphosphate phosphatase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005788 endoplasmic reticulum lumen;GO:0005886 plasma membrane", "go_biological_process": "GO:0030003 intracellular monoatomic cation homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9Z2L6-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q810U3-1", "uniprot_id": [ { "id": "NFASC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q810U3", "type": "external" } ], "mass": 137975.0, "length": 1240, "protein_name": "Neurofascin", "gene_name": "Nfasc", "organism": "Mouse", "refseq_name": "neurofascin isoform 1 precursor", "refseq_ac": [ { "id": "NP_874385", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_874385", "type": "external" } ], "gene_names_uniprotkb": "Nfasc", "gene_names_refseq": "D430023G06Rik; NF; Nfasc; mKIAA0756", "protein_names_uniprotkb": "Neurofascin", "protein_names_refseq": "neurofascin isoform 1 precursor", "tax_id": 10090, "disease": "MASA syndrome (Disease Ontology:DOID:0060246); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:269116); (R-MMU-447043); (R-MMU-6798695)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;23897819;30899004;33300544;34428180", "class_list": "", "function": "Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions., [UniProtKB, UniProtKB, UniProtKB]; This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined. [provided by RefSeq, May 2009]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 8, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 12, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 12, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 12, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 34, "disease_count": 2, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0098632 cell-cell adhesion mediator activity;GO:0086080 protein binding involved in heterotypic cell-cell adhesion", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043209 myelin sheath;GO:0033010 paranodal junction", "go_biological_process": "GO:0050808 synapse organization;GO:0072659 protein localization to plasma membrane;GO:0098609 cell-cell adhesion;GO:0007420 brain development;GO:0019226 transmission of nerve impulse", "synthesized_glycan_count": 0, "hit_score": 5.5, "record_id": "Q810U3-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29477-1", "uniprot_id": [ { "id": "NOS2_MOUSE", "url": "https://www.uniprot.org/uniprot/P29477", "type": "external" } ], "mass": 130575.0, "length": 1144, "protein_name": "Nitric oxide synthase, inducible", "gene_name": "Nos2", "organism": "Mouse", "refseq_name": "nitric oxide synthase, inducible isoform b", "refseq_ac": [ { "id": "NP_001300850", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001300850", "type": "external" } ], "gene_names_uniprotkb": "Nos2; Inosl", "gene_names_refseq": "MAC-NOS; NOS-II; Nos-2; Nos2a; Nos2; i-NOS; iNOS", "protein_names_uniprotkb": "Nitric oxide synthase, inducible; 1.14.13.39; Inducible NO synthase; Inducible NOS; MAC-NOS; Macrophage NOS; NOS type II; Peptidyl-cysteine S-nitrosylase NOS2; iNOS", "protein_names_refseq": "NOS type II; inducible NO synthase; inducible NOS; inducible nitric oxide synthase; macrophage NOS; nitric oxide synthase 2, inducible, macrophage; nitric oxide synthase, inducible isoform b; nitric oxide synthase, inducible; peptidyl-cysteine S-nitrosylase NOS2", "tax_id": 10090, "disease": "lissencephaly (Disease Ontology:DOID:0050453); inflammatory bowel disease (Disease Ontology:DOID:0050589); obstructive sleep apnea (Disease Ontology:DOID:0050848); stroke (Disease Ontology:DOID:0051061); colitis (Disease Ontology:DOID:0060180); respiratory allergy (Disease Ontology:DOID:0060496); mucositis (Disease Ontology:DOID:0080178); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); asthma, nasal polyps, and aspirin intolerance (Disease Ontology:DOID:0111579); sleeping sickness (Disease Ontology:DOID:10112); pleurisy (Disease Ontology:DOID:10247); asbestosis (Disease Ontology:DOID:10320); Alzheimer's disease (Disease Ontology:DOID:10652); renal hypertension (Disease Ontology:DOID:1073); otitis media (Disease Ontology:DOID:10754); hypertension (Disease Ontology:DOID:10763); essential hypertension (Disease Ontology:DOID:10825); gastroschisis (Disease Ontology:DOID:11044); meconium aspiration syndrome (Disease Ontology:DOID:11049); pneumocystosis (Disease Ontology:DOID:11339); pulmonary edema (Disease Ontology:DOID:11396); diabetic angiopathy (Disease Ontology:DOID:11713); allergic disease (Disease Ontology:DOID:1205); Lewy body dementia (Disease Ontology:DOID:12217); primary biliary cholangitis (Disease Ontology:DOID:12236); malaria (Disease Ontology:DOID:12365); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); dilated cardiomyopathy (Disease Ontology:DOID:12930); retinopathy of prematurity (Disease Ontology:DOID:13025); dementia (Disease Ontology:DOID:1307); lung cancer (Disease Ontology:DOID:1324); pulmonary sarcoidosis (Disease Ontology:DOID:13406); hepatic encephalopathy (Disease Ontology:DOID:13413); interstitial cystitis (Disease Ontology:DOID:13949); anterior uveitis (Disease Ontology:DOID:1407); toxic shock syndrome (Disease Ontology:DOID:14115); hypothyroidism (Disease Ontology:DOID:1459); cystic fibrosis (Disease Ontology:DOID:1485); pancreatic cancer (Disease Ontology:DOID:1793); epilepsy (Disease Ontology:DOID:1826); impotence (Disease Ontology:DOID:1875); hepatitis (Disease Ontology:DOID:2237); colon adenocarcinoma (Disease Ontology:DOID:234); bronchiolitis obliterans (Disease Ontology:DOID:2799); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); coronary artery disease (Disease Ontology:DOID:3393); middle cerebral artery infarction (Disease Ontology:DOID:3525); allergic rhinitis (Disease Ontology:DOID:4481); rhinitis (Disease Ontology:DOID:4483); uremia (Disease Ontology:DOID:4676); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); cholangiocarcinoma (Disease Ontology:DOID:4947); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); paraplegia (Disease Ontology:DOID:607); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); abdominal aortic aneurysm (Disease Ontology:DOID:7693); extrinsic allergic alveolitis (Disease Ontology:DOID:841); lung disease (Disease Ontology:DOID:850); alcoholic gastritis (Disease Ontology:DOID:8680); nasopharynx carcinoma (Disease Ontology:DOID:9261); type 2 diabetes mellitus (Disease Ontology:DOID:9352); allergic asthma (Disease Ontology:DOID:9415); pulmonary emphysema (Disease Ontology:DOID:9675); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:18126); (R-MMU-1222556); (R-MMU-392154); (R-MMU-9033241)", "pathway_count": 4, "publication_count": 31, "publication_id_list": "10438970;10562538;10562539;10769116;11669619;12437348;12464241;1372907;1373522;1379716;16373578;19144319;20484733;20603330;21199876;21750661;22073225;22081021;24970700;27802388;30084848;31219806;31599954;33231608;34428180;35432339;35978195;7503239;7544010;9334294;9516116", "class_list": "", "function": "Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase that is inducible by a combination of lipopolysaccharide and certain cytokines. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]., [RefSeq]; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:7503239). In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (PubMed:16373578). As component of the iNOS-S100A8/9 transnitrosylase complex is involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM (By similarity). Involved in inflammation, enhances the synthesis of pro-inflammatory mediators such as IL6 and IL8 (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed]; Produces nitric oxide (NO) which is a messenger molecule with diverse functions., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 1, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 70, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O70515;O70516;Q5SXT3;Q6P6A0;Q8R410", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.1.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4", "type": "external" }, { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "1.5.3.13", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.13", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "1.4.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1", "type": "external" }, { "id": "4.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.9", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "1.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.1", "type": "external" }, { "id": "1.5.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.7", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "1.2.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" } ], "go_molecular_function": "GO:0004517 nitric-oxide synthase activity;GO:0034617 tetrahydrobiopterin binding;GO:0003779 actin binding;GO:0005516 calmodulin binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005777 peroxisome;GO:0005829 cytosol", "go_biological_process": "GO:0006954 inflammatory response;GO:0010629 negative regulation of gene expression;GO:0018119 peptidyl-cysteine S-nitrosylation;GO:0032496 response to lipopolysaccharide;GO:0034612 response to tumor necrosis factor", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "P29477-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0100100000001.010.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91ZR4-1", "uniprot_id": [ { "id": "NEK8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91ZR4", "type": "external" } ], "mass": 75265.0, "length": 698, "protein_name": "Serine/threonine-protein kinase Nek8", "gene_name": "Nek8", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase Nek8", "refseq_ac": [ { "id": "NP_543125", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_543125", "type": "external" } ], "gene_names_uniprotkb": "Nek8; Jck", "gene_names_refseq": "4632401F23Rik; Nek8; b2b1449Clo; jck", "protein_names_uniprotkb": "Serine/threonine-protein kinase Nek8; 2.7.11.1; Never in mitosis A-related kinase 8; NimA-related protein kinase 8", "protein_names_refseq": "NIMA-related expressed kinase 8; juvenile cystic kidney; never in mitosis A-related kinase 8; nimA-related protein kinase 8; serine/threonine-protein kinase Nek8", "tax_id": 10090, "disease": "renal-hepatic-pancreatic dysplasia (Disease Ontology:DOID:0060259); amyotrophic lateral sclerosis type 24 (Disease Ontology:DOID:0081378); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); nephronophthisis 9 (Disease Ontology:DOID:0111120)", "pathway": " (mmu:140859)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "12421721;16267153;18199800;18235101;21750661;25428506;25671767;31219806;34428180;37598857;8510385", "class_list": "", "function": "Certain heterozygous variants in the kinase domain of the serine/threonine kinase NEK8 can cause an autosomal dominant form of polycystic kidney disease., [RefSeq, PubMed]; Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia. Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway., [UniProtKB, PubMed]; This gene encodes a NIMA-related kinase. Members of this serine/threonine protein kinase family are structurally-related to NIMA (never in mitosis, gene A) which controls mitotic signaling in Aspergillus nidulans. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U498;Q9D685", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0106310 protein serine kinase activity;GO:0004672 protein kinase activity", "go_cellular_component": "GO:0005813 centrosome;GO:0005929 cilium;GO:0005930 axoneme;GO:0097546 ciliary base;GO:0097543 ciliary inversin compartment", "go_biological_process": "GO:0035330 regulation of hippo signaling;GO:0007507 heart development;GO:0009887 animal organ morphogenesis;GO:0007368 determination of left/right symmetry", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q91ZR4-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P25233-1", "uniprot_id": [ { "id": "NECD_MOUSE", "url": "https://www.uniprot.org/uniprot/P25233", "type": "external" } ], "mass": 36832.0, "length": 325, "protein_name": "Necdin", "gene_name": "Ndn", "organism": "Mouse", "refseq_name": "necdin", "refseq_ac": [ { "id": "NP_035012", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035012", "type": "external" } ], "gene_names_uniprotkb": "Ndn", "gene_names_refseq": "Ndn; Peg6", "protein_names_uniprotkb": "Necdin", "protein_names_refseq": "necdin", "tax_id": 10090, "disease": "Prader-Willi syndrome (Disease Ontology:DOID:11983)", "pathway": " (mmu:17984)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10347180;10965153;2069569;34428180;8557705;9302265;9422723", "class_list": "", "function": "Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle-promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Also functions as a transcription factor and directly binds to specific guanosine-rich DNA sequences., [UniProtKB]; The necdin gene is imprinted, with preferential expression from the paternal allele in human and mouse., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9EJJ5;Q542W7;Q61951", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0043015 gamma-tubulin binding;GO:1990841 promoter-specific chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0003016 respiratory system process;GO:0006351 DNA-templated transcription;GO:0007409 axonogenesis;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P25233-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29595-1", "uniprot_id": [ { "id": "NEDD8_MOUSE", "url": "https://www.uniprot.org/uniprot/P29595", "type": "external" } ], "mass": 8972.0, "length": 81, "protein_name": "Ubiquitin-like protein NEDD8", "gene_name": "Nedd8", "organism": "Mouse", "refseq_name": "ubiquitin-like protein NEDD8", "refseq_ac": [ { "id": "NP_032709", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032709", "type": "external" } ], "gene_names_uniprotkb": "Nedd8; Nedd-8", "gene_names_refseq": "NEDD-8; Nedd8; Rub1", "protein_names_uniprotkb": "Ubiquitin-like protein NEDD8; NEDD-8; Neddylin; Neural precursor cell expressed developmentally down-regulated protein 8", "protein_names_refseq": "neddylin; neural precursor cell expressed developmentally down-regulated protein 8; ubiquitin-like protein NEDD8", "tax_id": 10090, "disease": "alcohol-associated liver disease (Disease Ontology:DOID:0070658); Parkinson's disease (Disease Ontology:DOID:14330); malignant astrocytoma (Disease Ontology:DOID:3069)", "pathway": " (mmu:18002); (R-MMU-2173789); (R-MMU-5689603); (R-MMU-8856825); (R-MMU-8951664); (R-MMU-917937)", "pathway_count": 6, "publication_count": 13, "publication_id_list": "10597293;11696557;12215427;1378265;15183309;21750661;23806337;26740625;28569775;31882005;34428180;8395831;9353319", "class_list": "", "function": "Downregulation of NEDD8 enhanced the susceptibility of nasopharyngeal carcinoma cells to cisplatin and radiation. Publication Status: Online-Only, [RefSeq, PubMed]; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis via its conjugation to a limited number of cellular proteins, such as cullins or p53/TP53 (PubMed:11696557). Attachment of NEDD8 to cullins is critical for the recruitment of E2 to the cullin-RING-based E3 ubiquitin-protein ligase complex, thus facilitating polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. Attachment of NEDD8 to p53/TP53 inhibits p53/TP53 transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M (By similarity). Neddylates EGFR resulting in protein stabilization and translocation to the cell membrane (By similarity)., [UniProtKB, PubMed, UniProtKB]; We present here the first evidence that the neuroinflammatory mediator IL-1beta facilitates ubiquitin ligase parkin/NEDD8 interactions Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0031386 protein tag activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0030162 regulation of proteolysis;GO:0008104 intracellular protein localization;GO:0072757 cellular response to camptothecin;GO:0019941 modification-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P29595-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BTG7-1", "uniprot_id": [ { "id": "NDRG4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BTG7", "type": "external" } ], "mass": 38509.0, "length": 352, "protein_name": "Protein NDRG4", "gene_name": "Ndrg4", "organism": "Mouse", "refseq_name": "protein NDRG4 isoform A", "refseq_ac": [ { "id": "NP_001181935", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181935", "type": "external" } ], "gene_names_uniprotkb": "Ndrg4; Kiaa1180; Ndr4", "gene_names_refseq": "D8Bwg1337e; Ndr1-rs; Ndr4; Ndrg4; SMAP-8", "protein_names_uniprotkb": "Protein NDRG4; N-myc downstream-regulated gene 4 protein; Protein Ndr4", "protein_names_refseq": "N-myc downstream regulated 1, related sequence; N-myc downstream-regulated gene 4 protein; protein NDRG4 isoform A; protein NDRG4; protein Ndr4", "tax_id": 10090, "disease": "glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070)", "pathway": " (mmu:234593)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "17114649;17998568;21183079;21636852;21750661;25428506;28524415;30084848;30779550;33300544;34203471;34428180;35820727;36210013", "class_list": "", "function": "Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress. May enhance growth factor-induced ERK1 and ERK2 phosphorylation. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner., [UniProtKB, PubMed]; NDRG4 is exclusively expressed by central, peripheral and enteric neurons/nerves, suggesting a neuronal-specific role of this protein, [RefSeq, PubMed]; These expression patterns demonstrated the cell type-specific and ubiquitous localization of the NDRG family proteins. Each NDRG may play a partially redundant role in specific cells in the brain., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZPW3;Q923D7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0008542 visual learning;GO:0010976 positive regulation of neuron projection development;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8BTG7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CR61-1", "uniprot_id": [ { "id": "NDUB7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CR61", "type": "external" } ], "mass": 16331.0, "length": 137, "protein_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7", "gene_name": "Ndufb7", "organism": "Mouse", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7", "refseq_ac": [ { "id": "NP_080119", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080119", "type": "external" } ], "gene_names_uniprotkb": "Ndufb7", "gene_names_refseq": "1110002H15Rik; Ndufb7", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7; CI-B18; Complex I-B18; NADH-ubiquinone oxidoreductase B18 subunit", "protein_names_refseq": "CI-B18; NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7; NADH-ubiquinone oxidoreductase B18 subunit; complex I-B18", "tax_id": 10090, "disease": "nuclear type mitochondrial complex I deficiency (Disease Ontology:DOID:0112065); depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (mmu:66916); (R-MMU-611105); (R-MMU-6799198)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "21183079;34428180;36288343;38575788;39927985", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008137 NADH dehydrogenase (ubiquinone) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0022904 respiratory electron transport chain;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9CR61-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WU39-1", "uniprot_id": [ { "id": "SCNNG_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WU39", "type": "external" } ], "mass": 74635.0, "length": 655, "protein_name": "Epithelial sodium channel subunit gamma", "gene_name": "Scnn1g", "organism": "Mouse", "refseq_name": "epithelial sodium channel subunit gamma", "refseq_ac": [ { "id": "NP_035456", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035456", "type": "external" } ], "gene_names_uniprotkb": "Scnn1g", "gene_names_refseq": "SCNEG; Scnn1g", "protein_names_uniprotkb": "Epithelial sodium channel subunit gamma; Amiloride-sensitive sodium channel subunit gamma; Epithelial Na(+) channel subunit gamma; Gamma-ENaC; Gamma-NaCH; Nonvoltage-gated sodium channel 1 subunit gamma; SCNEG", "protein_names_refseq": "ENaC gamma; amiloride-sensitive sodium channel subunit gamma; epithelial Na(+) channel subunit gamma; epithelial sodium channel subunit gamma; gamma-ENaC; gamma-NaCH; nonvoltage-gated sodium channel 1 subunit gamma", "tax_id": 10090, "disease": "Liddle syndrome (Disease Ontology:DOID:0050477); autosomal recessive pseudohypoaldosteronism type 1 (Disease Ontology:DOID:0060854); bronchiectasis 3 (Disease Ontology:DOID:0080528); neurodegenerative disease (Disease Ontology:DOID:1289); hypokalemic periodic paralysis (Disease Ontology:DOID:14452); ischemia (Disease Ontology:DOID:326); pseudohypoaldosteronism (Disease Ontology:DOID:4479)", "pathway": " (mmu:20278); (R-MMU-2672351); (R-MMU-9730628)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10409305;11244092;12424229;12871941;15007080;15123669;18650438;34428180;34681576;38634134", "class_list": "", "function": "Deletion of the Gamma Subunit of ENaC in Endothelial Cells Does Not Protect against Renal Ischemia Reperfusion Injury. Publication Status: Online-Only, [RefSeq, PubMed]; Influence of proteolytic cleavage of ENaC's gamma subunit upon Na[+] and K[+] handling., [RefSeq, PubMed]; This gene encodes the gamma subunit of the epithelial sodium channel, a member of the amiloride-sensitive sodium channel family of proteins. This channel regulates sodium homeostasis and blood pressure, by controlling sodium transport in the kidney, colon and lung. Proteolytic processing of the encoded protein results in the release of an inhibitory peptide and channel activation. Homozygous knockout mice for this gene exhibit perinatal lethality, likely due to excess serum potassium. [provided by RefSeq, Oct 2015]., [RefSeq]; This is one of the three pore-forming subunits of the heterotrimeric epithelial sodium channel (ENaC), a critical regulator of sodium balance and fluid homeostasis (PubMed:10409305, PubMed:12871941, PubMed:15007080). ENaC operates in epithelial tissues, where it mediates the electrodiffusion of sodium ions from extracellular fluid through the apical membrane of cells, with water following osmotically (PubMed:12871941, PubMed:15007080). It plays a key role in maintaining sodium homeostasis through electrogenic sodium reabsorption in the kidneys. Additionally, ENaC is essential for airway surface liquid homeostasis, which is crucial for proper mucus clearance (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005216 monoatomic ion channel activity;GO:0050699 WW domain binding;GO:0015280 ligand-gated sodium channel activity;GO:0005272 sodium channel activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0070062 extracellular exosome", "go_biological_process": "GO:0008217 regulation of blood pressure;GO:1904117 cellular response to vasopressin;GO:0006883 intracellular sodium ion homeostasis;GO:0035313 wound healing, spreading of epidermal cells;GO:0035725 sodium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9WU39-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q04207-1", "uniprot_id": [ { "id": "TF65_MOUSE", "url": "https://www.uniprot.org/uniprot/Q04207", "type": "external" } ], "mass": 60212.0, "length": 549, "protein_name": "Transcription factor p65", "gene_name": "Rela", "organism": "Mouse", "refseq_name": "transcription factor p65 isoform 1", "refseq_ac": [ { "id": "NP_033071", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033071", "type": "external" } ], "gene_names_uniprotkb": "Rela; Nfkb3", "gene_names_refseq": "Rela; p65 NF-kappa B; p65 NFkB; p65", "protein_names_uniprotkb": "Transcription factor p65; Nuclear factor NF-kappa-B p65 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3", "protein_names_refseq": "avian reticuloendotheliosis viral (v-rel) oncogene homolog A; nuclear factor NF-kappa-B p65 subunit; nuclear factor of kappa light polypeptide gene enhancer in B-cells 3; transcription factor p65 isoform 1; transcription factor p65; v-rel reticuloendotheliosis viral oncogene homolog A", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); obstructive sleep apnea (Disease Ontology:DOID:0050848); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); lymphoma (Disease Ontology:DOID:0060058); ductal carcinoma in situ (Disease Ontology:DOID:0060074); colitis (Disease Ontology:DOID:0060180); mastoiditis (Disease Ontology:DOID:0060322); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); Parkinsonism (Disease Ontology:DOID:0080855); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); bacterial infectious disease (Disease Ontology:DOID:104); otitis media (Disease Ontology:DOID:10754); hypertension (Disease Ontology:DOID:10763); cholesteatoma of middle ear (Disease Ontology:DOID:10964); urinary bladder cancer (Disease Ontology:DOID:11054); prostatic hypertrophy (Disease Ontology:DOID:11132); primary biliary cholangitis (Disease Ontology:DOID:12236); uveitis (Disease Ontology:DOID:13141); renovascular hypertension (Disease Ontology:DOID:1591); pancreatic cancer (Disease Ontology:DOID:1793); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); arteriosclerosis (Disease Ontology:DOID:2349); prostate adenocarcinoma (Disease Ontology:DOID:2526); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); lung non-small cell carcinoma (Disease Ontology:DOID:3908); renal cell carcinoma (Disease Ontology:DOID:4450); liver cirrhosis (Disease Ontology:DOID:5082); pulmonary hypertension (Disease Ontology:DOID:6432); end stage renal disease (Disease Ontology:DOID:783); prostate carcinoma in situ (Disease Ontology:DOID:8634); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); steatotic liver disease (Disease Ontology:DOID:9452); encephalitis (Disease Ontology:DOID:9588); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:19697); (R-MMU-1169091); (R-MMU-1810476); (R-MMU-193692); (R-MMU-202424); (R-MMU-209560); (R-MMU-2871837); (R-MMU-3134963); (R-MMU-3214841); (R-MMU-445989); (R-MMU-448706); (R-MMU-4755510); (R-MMU-5607764); (R-MMU-5621575); (R-MMU-9020702); (R-MMU-933542); (R-MMU-9860927); (R-MMU-9958825)", "pathway_count": 18, "publication_count": 69, "publication_id_list": "11931770;12559944;12874295;12881425;15051764;15485901;15616592;15833743;16192349;18025230;18199827;18299349;18362169;18710934;19168128;19249228;19609947;19706715;20007975;2001591;21072211;21131967;21159647;21183079;21596132;21750661;21999414;22140508;22244329;22645316;22761446;22895791;22921934;23616576;23806337;24274545;25024434;25629551;25835259;25915426;26370562;26593914;27075886;27555662;27927986;28378844;28600438;28723419;28865949;29813070;30042374;30405614;30867837;31409917;32038294;32908186;33939070;34428180;34668190;35530146;36149580;37349834;8281153;8816457;8918242;9437432;9450761;9865694;9990853", "class_list": "", "function": "NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric RELA-NFKB1 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. The NF-kappa-B heterodimeric RELA-NFKB1 and RELA-REL complexes, for instance, function as transcriptional activators. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The inhibitory effect of I-kappa-B on NF-kappa-B through retention in the cytoplasm is exerted primarily through the interaction with RELA. RELA shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Besides its activity as a direct transcriptional activator, it is also able to modulate promoters accessibility to transcription factors and thereby indirectly regulate gene expression (PubMed:29813070). Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (By similarity). The NF-kappa-B homodimeric RELA-RELA complex appears to be involved in invasin-mediated activation of IL-8 expression (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 35, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q62025", "ec_number_list": [], "go_molecular_function": "GO:0042301 phosphate ion binding;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse", "go_biological_process": "GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0046627 negative regulation of insulin receptor signaling pathway;GO:1904385 cellular response to angiotensin;GO:0070498 interleukin-1-mediated signaling pathway;GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell", "synthesized_glycan_count": 0, "hit_score": 7.6, "record_id": "Q04207-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08759-1", "uniprot_id": [ { "id": "UBE3A_MOUSE", "url": "https://www.uniprot.org/uniprot/O08759", "type": "external" } ], "mass": 99819.0, "length": 870, "protein_name": "Ubiquitin-protein ligase E3A", "gene_name": "Ube3a", "organism": "Mouse", "refseq_name": "ubiquitin-protein ligase E3A isoform 2", "refseq_ac": [ { "id": "NP_035798", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035798", "type": "external" } ], "gene_names_uniprotkb": "Ube3a", "gene_names_refseq": "4732496B02; 5830462N02Rik; A130086L21Rik; Hpve6a; Ube3a", "protein_names_uniprotkb": "Ubiquitin-protein ligase E3A; 2.3.2.26; HECT-type ubiquitin transferase E3A; Oncogenic protein-associated protein E6-AP", "protein_names_refseq": "E6-AP ubiquitin protein ligase; HECT-type ubiquitin transferase E3A; oncogenic protein-associated protein E6-AP; ubiquitin conjugating enzyme E3A; ubiquitin-protein ligase E3A isoform 2", "tax_id": 10090, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); autism spectrum disorder (Disease Ontology:DOID:0060041); chromosome 15q11.2 deletion syndrome (Disease Ontology:DOID:0060393); intellectual disability (Disease Ontology:DOID:1059); epilepsy (Disease Ontology:DOID:1826); Angelman syndrome (Disease Ontology:DOID:1932)", "pathway": " (mmu:22215); (R-MMU-983168)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "11895368;12668607;17242355;20211139;21183079;21750661;24728990;26255772;30020076;30084848;34428180;39627609;9110176;9182527;9808466", "class_list": "", "function": "E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates (PubMed:20211139, PubMed:24728990, PubMed:30020076). Several substrates have been identified including the BMAL1, ARC, LAMTOR1, RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B (PubMed:20211139, PubMed:24728990, PubMed:30020076). Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins. Finally, UBE3A also promotes its own degradation in vivo (By similarity). Plays an important role in the regulation of the circadian clock: involved in the ubiquitination of the core clock component BMAL1, leading to its proteasomal degradation (PubMed:24728990). Acts as a regulator of synaptic development by mediating ubiquitination and degradation of ARC (PubMed:20211139). Required for synaptic remodeling in neurons by mediating ubiquitination and degradation of LAMTOR1, thereby limiting mTORC1 signaling and activity-dependent synaptic remodeling (PubMed:30020076). Synergizes with WBP2 in enhancing PGR activity (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Ube3a exhibits brain cell type-specific imprinting, with monoallelic expression from the maternal allele in neurons, but biallelic expression in glial cells. The antisense Ube3a transcript is reciprocally imprinted only in neurons., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QKT1;P97482;Q8CE29", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005829 cytosol;GO:0008021 synaptic vesicle;GO:0000502 proteasome complex", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0048167 regulation of synaptic plasticity;GO:0032570 response to progesterone", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "O08759-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6ZPJ3-1", "uniprot_id": [ { "id": "UBE2O_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6ZPJ3", "type": "external" } ], "mass": 140834.0, "length": 1288, "protein_name": "(E3-independent) E2 ubiquitin-conjugating enzyme UBE2O", "gene_name": "Ube2o", "organism": "Mouse", "refseq_name": "(E3-independent) E2 ubiquitin-conjugating enzyme UBE2O isoform 1", "refseq_ac": [ { "id": "NP_776116", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776116", "type": "external" } ], "gene_names_uniprotkb": "Ube2o; Kiaa1734", "gene_names_refseq": "9630022H21; B230113M03Rik; E2-230K; Ube2o; mKIAA1734", "protein_names_uniprotkb": "(E3-independent) E2 ubiquitin-conjugating enzyme UBE2O; 2.3.2.24; E2/E3 hybrid ubiquitin-protein ligase UBE2O; Ubiquitin carrier protein O; Ubiquitin-conjugating enzyme E2 O; Ubiquitin-conjugating enzyme E2 of 230 kDa; Ubiquitin-conjugating enzyme E2-230K; Ubiquitin-protein ligase O", "protein_names_refseq": "(E3-independent) E2 ubiquitin-conjugating enzyme UBE2O isoform 1; (E3-independent) E2 ubiquitin-conjugating enzyme UBE2O; E2/E3 hybrid ubiquitin-protein ligase UBE2O; ubiquitin carrier protein O; ubiquitin-conjugating enzyme E2 of 230 kDa; ubiquitin-conjugating enzyme E2-230K; ubiquitin-protein ligase O; ubiquitinating enzyme E2-230 kDa", "tax_id": 10090, "disease": "", "pathway": " (mmu:217342); (R-MMU-983168)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "12522145;17242355;21183079;25153642;25605945;28528544;30084848;30779550;31219806;31268597;33300544;33725478;34418053;34887587;35820727;36345807;37182872;39627609;7761435;8634298", "class_list": "", "function": "Age-Associated UBE2O Reduction Promotes Neuronal Death in Alzheimer's Disease., [RefSeq, PubMed]; E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins. Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity. Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis. Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location. Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly. Mediates the monoubiquitination of cytoplasmic CTNNA1 to promote cell-to-extracellular matrix adhesions. Mechanistically, ubiquitination of CTNNA1 triggers a binding switch from beta- catenin to vinculin that directs CTNNA1 to mediate matrix adhesion., [UniProtKB, UniProtKB]; Over expression of ubiquitin-conjugating enzyme E2O in bone marrow mesenchymal stromal cells partially attenuates acute myeloid leukaemia progression., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2A7X3;Q60800;Q6PCR9;Q7TPN2;Q8BLE8", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "6.2.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.64", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016604 nuclear body", "go_biological_process": "GO:0030513 positive regulation of BMP signaling pathway;GO:0042147 retrograde transport, endosome to Golgi;GO:0070534 protein K63-linked ubiquitination;GO:0006513 protein monoubiquitination", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q6ZPJ3-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99NB8-1", "uniprot_id": [ { "id": "UBQL4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99NB8", "type": "external" } ], "mass": 63506.0, "length": 596, "protein_name": "Ubiquilin-4", "gene_name": "Ubqln4", "organism": "Mouse", "refseq_name": "ubiquilin-4 isoform 1", "refseq_ac": [ { "id": "NP_277068", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_277068", "type": "external" } ], "gene_names_uniprotkb": "Ubqln4; Cip75; Ubin", "gene_names_refseq": "A1Up; A1u; CIP75; UBIN; Ubqln4", "protein_names_uniprotkb": "Ubiquilin-4; A1Up; Ataxin-1 interacting ubiquitin-like protein; Ataxin-1 ubiquitin-like-interacting protein A1U; CIP75; Connexin43-interacting protein of 75 kDa", "protein_names_refseq": "ataxin-1 interacting ubiquitin-like protein; ataxin-1 ubiquitin-like interacting protein; ataxin-1 ubiquitin-like-interacting protein A1U; connexin43-interacting protein of 75 kDa; ubiquilin-4 isoform 1", "tax_id": 10090, "disease": "amyotrophic lateral sclerosis type 15 (Disease Ontology:DOID:0060206); neurodegenerative disease (Disease Ontology:DOID:1289); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); frontotemporal dementia (Disease Ontology:DOID:9255)", "pathway": " (mmu:94232)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11162551;18079109;20127391;20940304;21750661;25153642;25428506;26495903;27113755;30084848;30779550", "class_list": "", "function": "A novel connexin43-interacting protein, CIP75, which belongs to the UbL-UBA protein family, regulates the turnover of connexin43, [RefSeq, PubMed]; Although CIP75 can interact with ubiquitinated cellular proteins, its interaction with Cx43 and stimulation of Cx43 proteasomal degradation does not require the ubiquitination of Cx43., [RefSeq, PubMed]; Regulator of protein degradation that mediates the proteasomal targeting of misfolded, mislocalized or accumulated proteins (By similarity). Acts by binding polyubiquitin chains of target proteins via its UBA domain and by interacting with subunits of the proteasome via its ubiquitin-like domain (By similarity). Key regulator of DNA repair that represses homologous recombination repair: in response to DNA damage, recruited to sites of DNA damage following phosphorylation by ATM and acts by binding and removing ubiquitinated MRE11 from damaged chromatin, leading to MRE11 degradation by the proteasome (By similarity). MRE11 degradation prevents homologous recombination repair, redirecting double-strand break repair toward non-homologous end joining (NHEJ) (By similarity). Specifically recognizes and binds mislocalized transmembrane-containing proteins and targets them to proteasomal degradation (By similarity). Collaborates with DESI1/POST in the export of ubiquitinated proteins from the nucleus to the cytoplasm (By similarity). Plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (PubMed:18079109, PubMed:20940304). Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery (By similarity). Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; UBQLN4 recognizes not only the defective model substrate but also a pool of endogenous defective proteins that were induced by the depletion of the SRP54 subunit of the signal recognition particle., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8BP88", "ec_number_list": [], "go_molecular_function": "GO:0036435 K48-linked polyubiquitin modification-dependent protein binding;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0031597 cytosolic proteasome complex;GO:0031595 nuclear proteasome complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:1901097 negative regulation of autophagosome maturation;GO:2000042 negative regulation of double-strand break repair via homologous recombination;GO:0006281 DNA repair;GO:0006974 DNA damage response;GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q99NB8-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQ79-1", "uniprot_id": [ { "id": "TXND9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQ79", "type": "external" } ], "mass": 26260.0, "length": 226, "protein_name": "Thioredoxin domain-containing protein 9", "gene_name": "Txndc9", "organism": "Mouse", "refseq_name": "thioredoxin domain-containing protein 9 isoform a", "refseq_ac": [ { "id": "NP_742051", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742051", "type": "external" } ], "gene_names_uniprotkb": "Txndc9; Apacd", "gene_names_refseq": "APACD; Txndc9", "protein_names_uniprotkb": "Thioredoxin domain-containing protein 9; ATP-binding protein associated with cell differentiation", "protein_names_refseq": "ATP binding protein associated with cell differentiation; thioredoxin domain-containing protein 9 isoform a; thioredoxin domain-containing protein 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:98258)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15009089;21750661;28626760;34428180;35820727", "class_list": "", "function": "Results demonstrated that Txndc9 is crucial for mouse oocyte maturation by regulating spindle assembly, polar body extrusion, and redox status., [RefSeq, PubMed]; Significantly diminishes the chaperonin TCP1 complex ATPase activity, thus negatively impacts protein folding, including that of actin or tubulin., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TKD2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0030496 midbody", "go_biological_process": "GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CQ79-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91X17-1", "uniprot_id": [ { "id": "UROM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91X17", "type": "external" } ], "mass": 70845.0, "length": 642, "protein_name": "Uromodulin", "gene_name": "Umod", "organism": "Mouse", "refseq_name": "uromodulin preproprotein", "refseq_ac": [ { "id": "NP_001265534", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001265534", "type": "external" } ], "gene_names_uniprotkb": "Umod", "gene_names_refseq": "THP; Umod; Urehd1; urehr4", "protein_names_uniprotkb": "Uromodulin; THP; Tamm-Horsfall urinary glycoprotein", "protein_names_refseq": "Tamm-Horsfall urinary glycoprotein; uromodulin preproprotein; uromucoid", "tax_id": 10090, "disease": "autosomal dominant tubulointerstitial kidney disease (Disease Ontology:DOID:0060062); autosomal dominant tubulointerstitial kidney disease 1 (Disease Ontology:DOID:0061122); kidney disease (Disease Ontology:DOID:557)", "pathway": " (mmu:22242); (R-MMU-446203)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;11134021;12021773;14665435;14871399;15327412;18375198;21750661;25428506;26673890;31044023;34428180;39007512;7873609", "class_list": "", "function": "Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability. May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelia., [UniProtKB, UniProtKB]; In the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes and inhibits formation of liquid containing supersaturated salts and subsequent formation of salt crystals (PubMed:14871399, PubMed:15327412). Protects against urinary tract infections by binding to type 1 fimbriated E.coli (PubMed:11134021). Binds to the bacterial adhesin fimH which mediates the stable formation of bacterial aggregates, prevents the binding of E.coli to uroplakins UPK1A and UPK1B which act as urothelial receptors for type I fimbriae, and allows for pathogen clearance through micturation (By similarity). Also promotes aggregation of other bacteria including K.pneumoniae, P.aeruginosa and S.mitis and so may also protect against other uropathogens (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; Increased water intake dilutes protective uromodulin levels in urine and results in increased rates of pyelonephritis in a murine model., [RefSeq, PubMed]; Potential THP defects, either quantitative or qualitative, could predispose the urinary bladder to bacterial infections, [RefSeq, PubMed]; THP is a critical urinary defense factor and its deficiency could be an important contributing factor in nephrolithiasis, [RefSeq, PubMed]; THP serves as a soluble receptor for type 1 fimbriated E. coli and helps eliminate bacteria from the urinary tract., [RefSeq, PubMed]; This gene encodes a glycoprotein that is the most abundant protein in mammalian urine under physiological conditions. It is synthesized in the kidney as a glycosyl-phosphatidylinositol anchored protein and released into urine as a soluble form by proteolytic cleavage. It is thought to regulate water and salt balance in the thick ascending limb of Henle and to protect against urinary tract infection and calcium oxalate crystal formation. In mouse deficiency of this gene is associated with increased susceptibility to bacterial infections and formation of calcium crystals in kidneys. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]., [RefSeq]; Urinary uromodulin is generated by a conserved C-terminal proteolytic cleavage and retains its entire ZP domain., [RefSeq, PubMed]", "predicted_glycosites": 10, "predicted_n_glycosites": 9, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "Q3TN64;Q3TP60;Q62285", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0019864 IgG binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005929 cilium", "go_biological_process": "GO:0072070 loop of Henle development;GO:0071918 urea transmembrane transport;GO:0051223 regulation of protein transport;GO:0030644 intracellular chloride ion homeostasis;GO:0072218 metanephric ascending thin limb development", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q91X17-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AN08-1", "uniprot_id": [ { "id": "UBR4_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AN08", "type": "external" } ], "mass": 572290.0, "length": 5180, "protein_name": "E3 ubiquitin-protein ligase UBR4", "gene_name": "Ubr4", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase UBR4", "refseq_ac": [ { "id": "NP_001153791", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153791", "type": "external" } ], "gene_names_uniprotkb": "Ubr4; Kiaa0462", "gene_names_refseq": "1810009A16Rik; A930005E13Rik; D930005K06Rik; Gm1032; Gm1666; RBAF600; Ubr4; Zubr1; mKIAA0462; p600", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase UBR4; 2.3.2.27; N-recognin-4", "protein_names_refseq": "E3 ubiquitin-protein ligase UBR4; N-recognin-4; RING-type E3 ubiquitin transferase UBR4; retinoblastoma-associated factor 600; zinc finger UBR1-type protein 1; zinc finger, UBR1 type 1", "tax_id": 10090, "disease": "intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (mmu:69116); (R-MMU-6798695); (R-MMU-983168)", "pathway_count": 3, "publication_count": 26, "publication_id_list": "10.1101/2023.09.13.557529;16055722;16081543;17242355;18385319;19008229;19892989;20485683;21183079;21750661;22645316;22872234;23431188;25428506;30084848;30111582;31219806;33300544;34203471;34428180;35820727;36210013;37507081;37828378;40885482;41018975", "class_list": "", "function": "Bovine papillomavirus E7 transformation function correlates with cellular p600 protein binding in mice. GeneRIF: Found murine p600 (formally called RBAF600) copurified with the E7 oncoprotein in C127 cells. This interaction was found to correlate with the ability of E7 to increase transformation. Erratum:[Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):3007], [RefSeq, PubMed]; E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm (PubMed:16055722, PubMed:19008229, PubMed:30111582). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:16055722, PubMed:19008229). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (PubMed:16055722, PubMed:19008229). Does not ubiquitinate proteins that are acetylated at the N-terminus (By similarity). Together with UBR5, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR4 probably synthesizes mixed chains containing multiple linkages, while UBR5 is likely branching multiple 'Lys-48'-linked chains of substrates initially modified (By similarity). Together with KCMF1, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (By similarity). Catalytic component of the silencing factor of the integrated stress response (SIFI) complex, a multiprotein complex that turns off the mitochondrial stress response after a specific stress event has been resolved (By similarity). The SIFI complex ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors such as ABHD10 (By similarity). Within the SIFI complex, UBR4 initiates ubiquitin chains that are further elongated or branched by KCMF1 (By similarity). Mediates ubiquitination of ACLY, leading to its subsequent degradation (By similarity). Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Member of UBR box protein family, termed Ubr4. Binds to destabilizing N-terminal residues of N-end rule substrates. Participates in degradation of N-end rule substrates., [RefSeq, PubMed]; This study identified protein 600 (p600) as a novel microtubule-associated protein (MAP) developmentally regulated in neurons. p600 exhibits the unique feature to interact with the endoplasmic reticulum (ER)., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A2AN07;A2AN09;A2AN10;A2AN11;Q52KI4;Q6PB49;Q6PFC7;Q80Y11;Q8BGB9;Q8C3E8;Q8C4W5;Q8C8X7;Q8CGE0;Q8CHF3", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "1.14.19.17", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.17", "type": "external" }, { "id": "5.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.-", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "3.4.21.73", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.73", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "3.2.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.20", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "2.3.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.78", "type": "external" }, { "id": "1.6.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.-", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "3.4.16.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.2", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "3.6.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.29", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "2.3.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.20", "type": "external" }, { "id": "2.3.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.76", "type": "external" } ], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0045717 negative regulation of fatty acid biosynthetic process;GO:0006633 fatty acid biosynthetic process;GO:0060337 type I interferon-mediated signaling pathway;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "A2AN08-1", "record_type": "protein", "filter_code": "0000000.1000111.000100.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C7R4-1", "uniprot_id": [ { "id": "UBA6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C7R4", "type": "external" } ], "mass": 117966.0, "length": 1053, "protein_name": "Ubiquitin-like modifier-activating enzyme 6", "gene_name": "Uba6", "organism": "Mouse", "refseq_name": "ubiquitin-like modifier-activating enzyme 6", "refseq_ac": [ { "id": "NP_766300", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766300", "type": "external" } ], "gene_names_uniprotkb": "Uba6; Ube1l2", "gene_names_refseq": "4930542H01; 5730469D23Rik; E1-L2; Uba6; Ube1l2", "protein_names_uniprotkb": "Ubiquitin-like modifier-activating enzyme 6; 6.2.1.45; E1-L2; Ubiquitin-activating enzyme 6; Ubiquitin-activating enzyme E1-like protein 2", "protein_names_refseq": "ubiquitin-activating enzyme 6; ubiquitin-activating enzyme E1-like 2; ubiquitin-activating enzyme E1-like protein 2; ubiquitin-like modifier-activating enzyme 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:231380); (R-MMU-8866652); (R-MMU-983168)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "17889673;21750661;23499007;23806337;25153642;28135057;28528544;31060776;31219806;34428180;34678516;35011668;36109526;39627609", "class_list": "", "function": "Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (By similarity). Specific for ubiquitin, does not activate ubiquitin-like peptides. Also activates UBD/FAT10 conjugation via adenylation of its C-terminal glycine (PubMed:17889673). Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development., [UniProtKB, UniProtKB, PubMed]; Early-stage paired housing improves social interaction in neuronal Uba6-deficient mice as a model of autism spectrum disorder., [RefSeq, PubMed]; Inhibition of UBA6 by inosine augments tumour immunogenicity and responses. Publication Status: Online-Only, [RefSeq, PubMed]; The identification of an E1-like protein, termed E1-L2, that activates both ubiquitin and another ubiquitin-like protein, FAT10, is reported., [RefSeq, PubMed]; Uba6 and Use1 promote proteasomal turnover of Ube3a in mouse embryo fibroblasts (MEFs) and catalyze Ube3a ubiquitylation in vitro., [RefSeq, PubMed]; Ubiquitin Activating Enzyme UBA6 Regulates Th1 and Tc1 Cell Differentiation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "6.2.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.64", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004839 ubiquitin activating enzyme activity;GO:0019780 FAT10 activating enzyme activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0007612 learning;GO:0007626 locomotory behavior;GO:0021766 hippocampus development;GO:0006974 DNA damage response;GO:0060996 dendritic spine development", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q8C7R4-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VBW6-1", "uniprot_id": [ { "id": "ULA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VBW6", "type": "external" } ], "mass": 60274.0, "length": 534, "protein_name": "NEDD8-activating enzyme E1 regulatory subunit", "gene_name": "Nae1", "organism": "Mouse", "refseq_name": "NEDD8-activating enzyme E1 regulatory subunit isoform 1", "refseq_ac": [ { "id": "NP_659180", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659180", "type": "external" } ], "gene_names_uniprotkb": "Nae1; Appbp1", "gene_names_refseq": "59kDa; Appbp1; Nae1", "protein_names_uniprotkb": "NEDD8-activating enzyme E1 regulatory subunit; APP-BP1; Amyloid beta precursor protein-binding protein 1, 59 kDa; Amyloid protein-binding protein 1", "protein_names_refseq": "APP-BP1; NEDD8-activating enzyme E1 regulatory subunit isoform 1; NEDD8-activating enzyme E1 regulatory subunit; amyloid beta precursor protein binding protein 1, 59kDa; amyloid beta precursor protein-binding protein 1, 59 kDa; amyloid protein-binding protein 1", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); middle cerebral artery infarction (Disease Ontology:DOID:3525)", "pathway": " (mmu:234664)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "16049335;21151996;21750661;21952136;22872234;23806337;25428506;25605945;30084848;34428180;37507081;39927985;40885482", "class_list": "", "function": "APP-BP1 plays an important role in the cell cycle progression of fetal neural stem cells Publication Status: Online-Only, [RefSeq, PubMed]; Cerebral microvascular amyloid beta protein deposition induces vascular degeneration and neuroinflammation in transgenic mice expressing human vasculotropic mutant amyloid beta precursor protein, [RefSeq, PubMed]; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation (By similarity). The covalent attachment of NEDD8 to target proteins is known as 'neddylation' and the process is involved in the regulation of cell growth, viability and development., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8CFL6", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0031625 ubiquitin protein ligase binding;GO:0019781 NEDD8 activating enzyme activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0051402 neuron apoptotic process;GO:0042981 regulation of apoptotic process;GO:0043523 regulation of neuron apoptotic process;GO:0045116 protein neddylation;GO:0033314 mitotic DNA replication checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8VBW6-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52479-1", "uniprot_id": [ { "id": "UBP10_MOUSE", "url": "https://www.uniprot.org/uniprot/P52479", "type": "external" } ], "mass": 87022.0, "length": 792, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 10", "gene_name": "Usp10", "organism": "Mouse", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 10 isoform 2", "refseq_ac": [ { "id": "NP_001297559", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297559", "type": "external" } ], "gene_names_uniprotkb": "Usp10; Kiaa0190; Ode-1; Uchrp", "gene_names_refseq": "2610014N07Rik; UBPO; Uchrp; Usp10; mKIAA0190", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 10; 3.4.19.12; Deubiquitinating enzyme 10; Ubiquitin thioesterase 10; Ubiquitin-specific-processing protease 10", "protein_names_refseq": "deubiquitinating enzyme 10; ubiquintin c-terminal hydrolase related polypeptide; ubiquitin carboxyl-terminal hydrolase 10 isoform 2; ubiquitin carboxyl-terminal hydrolase 10; ubiquitin specific protease 10; ubiquitin thioesterase 10; ubiquitin thiolesterase 10; ubiquitin-specific-processing protease 10", "tax_id": 10090, "disease": "", "pathway": " (mmu:22224); (R-MMU-5656169); (R-MMU-5689880)", "pathway_count": 3, "publication_count": 21, "publication_id_list": "15345747;17242355;18630941;18632802;19144319;21183079;21750661;21952136;22645316;25153642;25428506;28135057;28528544;30084848;31219806;34428180;36210013;38456416;38705504;39236936;39627609", "class_list": "", "function": "Epidermal Growth Factor-Like Repeats and Discoidin I-Like Domains 3 Deficiency Attenuates Dilated Cardiomyopathy by Inhibiting Ubiquitin Specific Peptidase 10 Dependent Smad4 Deubiquitination., [RefSeq, PubMed]; Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, RPS2/us5, RPS3/us3, RPS10/eS10, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Plays a key role in 40S ribosome subunit recycling when a ribosome has stalled during translation: acts both by inhibiting formation of stress granules, which store stalled translation pre-initiation complexes, and mediating deubiquitination of 40S ribosome subunits. Acts as a negative regulator of stress granules formation by lowering G3BP1 and G3BP2 valence, thereby preventing G3BP1 and G3BP2 ability to undergo liquid-liquid phase separation (LLPS) and assembly of stress granules. Promotes 40S ribosome subunit recycling following ribosome dissociation in response to ribosome stalling by mediating deubiquitination of 40S ribosomal proteins RPS2/us5, RPS3/us3 and RPS10/eS10, thereby preventing their degradation by the proteasome. Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): USP10 acts by removing monoubiquitination of RPS2/us5 and RPS3/us3, promoting 40S ribosomal subunit recycling. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. Involved in a TANK-dependent negative feedback response to attenuate NF-kappa-B activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage. Deubiquitinates TBX21 leading to its stabilization. Plays a negative role in the RLR signaling pathway upon RNA virus infection by blocking the RIGI-mediated MAVS activation. Mechanistically, removes the unanchored 'Lys-63'-linked polyubiquitin chains of MAVS to inhibit its aggregation, essential for its activation., [UniProtKB, UniProtKB]; USP10 alleviates Nepsilon-carboxymethyl-lysine-induced vascular calcification and atherogenesis in diabetes mellitus by promoting AMPK activation., [RefSeq, PubMed]; USP10-mediated deubiquitination of NR3C1 regulates bone homeostasis by controlling CST3 expression., [RefSeq, PubMed]; Vasopressin-induced Usp10 deubiquitylates and stabilizes endogenous SNX3 and consequently promotes cell surface expression of ENaC in kidney, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3T9L4;Q3TNN5;Q3TZB8;Q3U5E0;Q6ZQG9;Q91VY7", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.-", "type": "external" } ], "go_molecular_function": "GO:0044325 transmembrane transporter binding;GO:0002039 p53 binding;GO:0004197 cysteine-type endopeptidase activity;GO:0004843 cysteine-type deubiquitinase activity;GO:0140678 molecular function inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005829 cytosol", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0006281 DNA repair;GO:0006338 chromatin remodeling;GO:0010506 regulation of autophagy;GO:0016579 protein deubiquitination", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P52479-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02053-1", "uniprot_id": [ { "id": "UBA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q02053", "type": "external" } ], "mass": 117809.0, "length": 1058, "protein_name": "Ubiquitin-like modifier-activating enzyme 1", "gene_name": "Uba1", "organism": "Mouse", "refseq_name": "ubiquitin-like modifier-activating enzyme 1", "refseq_ac": [ { "id": "NP_001129557", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129557", "type": "external" } ], "gene_names_uniprotkb": "Uba1; Sbx; Ube1ax; Ube1x; Ube1", "gene_names_refseq": "A1S9; Sbx; Uba1; Ube-1; Ube1x", "protein_names_uniprotkb": "Ubiquitin-like modifier-activating enzyme 1; 6.2.1.45; Ubiquitin-activating enzyme E1 X; Ubiquitin-activating enzyme E1; Ubiquitin-like modifier-activating enzyme 1 X", "protein_names_refseq": "ubiquitin-activating enzyme E1, Chr X; ubiquitin-like modifier-activating enzyme 1", "tax_id": 10090, "disease": "VEXAS syndrome (Disease Ontology:DOID:0080828); X-linked spinal muscular atrophy 2 (Disease Ontology:DOID:0111827)", "pathway": " (mmu:22201); (R-MMU-8866652); (R-MMU-983168)", "pathway_count": 3, "publication_count": 26, "publication_id_list": "10.1101/2023.09.13.557529;1511901;15774460;16139798;1684224;17242355;17947660;21183079;22645316;23806337;24788674;25153642;26740625;30084848;31219806;34428180;34887587;35984892;36288343;37453647;37507081;39627609;39927985;7714913;7937138;8948595", "class_list": "", "function": "Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1511901). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites., [UniProtKB, UniProtKB, PubMed]; This gene encodes a member of the ubiquitin-activating E1 family. The encoded protein initiates the ubiquitin activation and transfer cascade, catalyzing the first step in ubiquitin conjugation to mark cellular proteins for proteasome degradation. Ubiquitin activating enzymes use ATP to form a thioester between a conserved catalytic cysteine of the enzyme and the C-terminal carboxylate of ubiquitin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A6H6S6;P31253;Q542H8", "ec_number_list": [ { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "6.2.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.64", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004839 ubiquitin activating enzyme activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006974 DNA damage response;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "Q02053-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6WKZ8-1", "uniprot_id": [ { "id": "UBR2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6WKZ8", "type": "external" } ], "mass": 199155.0, "length": 1755, "protein_name": "E3 ubiquitin-protein ligase UBR2", "gene_name": "Ubr2", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase UBR2 isoform 2", "refseq_ac": [ { "id": "NP_001170845", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001170845", "type": "external" } ], "gene_names_uniprotkb": "Ubr2; Kiaa0349", "gene_names_refseq": "9930021A08Rik; E130209G04Rik; Ubr2; mKIAA0349", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase UBR2; 2.3.2.27; N-recognin-2; Ubiquitin-protein ligase E3-alpha-2; Ubiquitin-protein ligase E3-alpha-II", "protein_names_refseq": "E3 ubiquitin-protein ligase UBR2 isoform 2; E3 ubiquitin-protein ligase UBR2; N-recognin-2; RING-type E3 ubiquitin transferase UBR2; ubiquitin ligase E3 alpha-II; ubiquitin-protein ligase E3-alpha-2; ubiquitin-protein ligase E3-alpha-II", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (mmu:224826); (R-MMU-983168)", "pathway_count": 2, "publication_count": 32, "publication_id_list": "10.1101/2023.09.13.557529;14585983;15548684;16311597;16488448;16606826;18299400;19008229;19224205;19892989;20080676;20173027;20484733;21103378;21750661;22872234;25428506;25428507;28708824;28806172;30084848;30779550;30872531;31219806;31268597;34203471;34428180;35820727;36252004;37507081;37828378;38225265", "class_list": "", "function": "E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (PubMed:14585983, PubMed:19008229, PubMed:30872531, PubMed:31268597). Recognizes and binds to proteins bearing specific N-terminal residues (N-degrons) that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (PubMed:14585983, PubMed:19008229, PubMed:30872531, PubMed:31268597). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (PubMed:19008229). Does not ubiquitinate proteins that are acetylated at the N-terminus (By similarity). In contrast, it strongly binds methylated N-degrons (By similarity). Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A (PubMed:14585983, PubMed:20080676). Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth (By similarity). Required for spermatogenesis, promotes, with Tex19.1, SPO11-dependent recombination foci to accumulate and drive robust homologous chromosome synapsis (PubMed:28708824). Polyubiquitinates LINE-1 retrotransposon encoded, LIRE1, which induces degradation, inhibiting LINE-1 retrotransposon mobilization (PubMed:28806172). Catalyzes ubiquitination and degradation of the N-terminal part of NLRP1B following NLRP1B activation by pathogens and other damage-associated signals: ubiquitination promotes degradation of the N-terminal part and subsequent release of the cleaved C-terminal part of NLRP1B, which polymerizes and forms the NLRP1B inflammasome followed by host cell pyroptosis (PubMed:30872531, PubMed:31268597). Plays a role in T-cell receptor signaling by inducing 'Lys-63'-linked ubiquitination of lymphocyte cell-specific kinase LCK (PubMed:38225265). This activity is regulated by DUSP22, which induces 'Lys-48'-linked ubiquitination of UBR2, leading to its proteasomal degradation by SCF E3 ubiquitin-protein ligase complex (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; UBR2 targets myosin heavy chain IIb and IIx for degradation: Molecular mechanism essential for cancer-induced muscle wasting., [RefSeq, PubMed]; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6DIB9;Q80U31;Q8BUL9;Q8CGW0;Q8K2I6;Q8R0V7;Q8R130", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0070728 L-leucine binding;GO:0141053 histone H2A ubiquitin ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0007283 spermatogenesis;GO:0050852 T cell receptor signaling pathway;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0050862 positive regulation of T cell receptor signaling pathway;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "Q6WKZ8-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q78IK2-1", "uniprot_id": [ { "id": "ATPMK_MOUSE", "url": "https://www.uniprot.org/uniprot/Q78IK2", "type": "external" } ], "mass": 6382.0, "length": 58, "protein_name": "ATP synthase F(0) complex subunit k, mitochondrial", "gene_name": "Atp5mk", "organism": "Mouse", "refseq_name": "ATP synthase F(0) complex subunit k, mitochondrial", "refseq_ac": [ { "id": "NP_075700", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075700", "type": "external" } ], "gene_names_uniprotkb": "Atp5mk; Atp5md; Dapit; Usmg5", "gene_names_refseq": "2010301L15Rik; Atp5md; Atp5mk; Usmg5", "protein_names_uniprotkb": "ATP synthase F(0) complex subunit k, mitochondrial; ATP synthase membrane subunit DAPIT, mitochondrial; Diabetes-associated protein in insulin-sensitive tissues; Up-regulated during skeletal muscle growth protein 5", "protein_names_refseq": "ATP synthase F(0) complex subunit k, mitochondrial; ATP synthase membrane subunit DAPIT, mitochondrial; ATP synthase membrane subunit K, mitochondrial; diabetes-associated protein in insulin-sensitive tissues; up-regulated during skeletal muscle growth protein 5; upregulated during skeletal muscle growth 5", "tax_id": 10090, "disease": "mitochondrial complex V (ATP synthase) deficiency nuclear type 6 (Disease Ontology:DOID:0111749)", "pathway": " (mmu:66477); (R-MMU-163210); (R-MMU-8949613)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "23576753;30084848;31219806;34428180;36288343;37453647;37507081", "class_list": "", "function": "Subunit k, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (By similarity). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (By similarity). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (By similarity). Required for dimerization of the ATP synthase complex and as such regulates ATP synthesis in the mitochondria (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9ER48", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q78IK2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CGY6-1", "uniprot_id": [ { "id": "UN45B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CGY6", "type": "external" } ], "mass": 103638.0, "length": 931, "protein_name": "Protein unc-45 homolog B", "gene_name": "Unc45b", "organism": "Mouse", "refseq_name": "protein unc-45 homolog B isoform 1", "refseq_ac": [ { "id": "NP_848795", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848795", "type": "external" } ], "gene_names_uniprotkb": "Unc45b; Cmya4", "gene_names_refseq": "Cmya4; D230041A13Rik; UNC-45B; Unc45b; Unc45", "protein_names_uniprotkb": "Protein unc-45 homolog B; Unc-45B", "protein_names_refseq": "cardiomyopathy associated 4; protein unc-45 homolog B isoform 1; protein unc-45 homolog B; striated muscle UNC45", "tax_id": 10090, "disease": "myofibrillar myopathy 11 (Disease Ontology:DOID:0081338); cataract 43 (Disease Ontology:DOID:0110259)", "pathway": " (mmu:217012)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12356907;18326487;18478096;25428506;30084848;31599954;37507081;39927985", "class_list": "", "function": "Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain. Plays a role in sarcomere formation during muscle cell development (PubMed:12356907, PubMed:18326487, PubMed:18478096). Is necessary for normal early lens development (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; Mammalian Unc45b is a cytosolic protein that forms a stable complex with Hsp90, selectively binds the unfolded conformation of the myosin motor domain, and promotes motor domain folding Publication Status: Online-Only, [RefSeq, PubMed]; Vertebrate Unc45 isoforms clearly demonstrates a direct role for Unc45 in Hsp90-mediated myosin motor domain folding and highlights major differences between the isoforms in substrate specificity and mechanism, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5XG72;Q8BHC5;Q8BWK3", "ec_number_list": [], "go_molecular_function": "GO:0051879 Hsp90 protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0030018 Z disc;GO:0031672 A band", "go_biological_process": "GO:0030154 cell differentiation;GO:0007517 muscle organ development;GO:0006457 protein folding;GO:0002088 lens development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8CGY6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K1B8-1", "uniprot_id": [ { "id": "URP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K1B8", "type": "external" } ], "mass": 75635.0, "length": 665, "protein_name": "Fermitin family homolog 3", "gene_name": "Fermt3", "organism": "Mouse", "refseq_name": "fermitin family homolog 3", "refseq_ac": [ { "id": "NP_722490", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_722490", "type": "external" } ], "gene_names_uniprotkb": "Fermt3; Kind3; Urp2", "gene_names_refseq": "Fermt3; Kindlin3", "protein_names_uniprotkb": "Fermitin family homolog 3; Kindlin-3; Unc-112-related protein 2", "protein_names_refseq": "fermitin family homolog 3; unc-112-related protein 2", "tax_id": 10090, "disease": "Kindler syndrome (Disease Ontology:DOID:0060472); leukocyte adhesion deficiency 1 (Disease Ontology:DOID:0110910); leukocyte adhesion deficiency 3 (Disease Ontology:DOID:0110912); ovarian cancer (Disease Ontology:DOID:2394); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (mmu:108101); (R-MMU-114608)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "16876785;18278053;18662549;19234460;19234461;21750661;25605945;26495903;29125738;29187734;31219806;34428180;37507081;38255822;39627609", "class_list": "", "function": "Identify a genetic disease that severely compromises the health of the affected individuals and establish an essential role of KINDLIN-3 in integrin activation in humans, [RefSeq, PubMed]; Immune-Related Molecules CD3G and FERMT3: Novel Biomarkers Associated with Sepsis. Publication Status: Online-Only, [RefSeq, PubMed]; Kindlin-3 was identified as a novel and essential element for platelet integrin activation in hemostasis and thrombosis., [RefSeq, PubMed]; Plays a central role in cell adhesion in hematopoietic cells (By similarity). Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3) (PubMed:18278053). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells (PubMed:19234461). Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (PubMed:18278053)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Stable isotope labeling by amino acids in cell culture confirmed their absence and disclosed a structural defect of the red blood cell membrane skeleton in Kindlin-3-deficient erythrocytes., [RefSeq, PubMed]; The genomic organization, gene expression and subcellular localization of murine Kindlins-1 to -3, is described., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0002102 podosome;GO:0030055 cell-substrate junction", "go_biological_process": "GO:0007229 integrin-mediated signaling pathway;GO:0030335 positive regulation of cell migration;GO:0007160 cell-matrix adhesion;GO:0033632 regulation of cell-cell adhesion mediated by integrin;GO:0007159 leukocyte cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q8K1B8-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35123-1", "uniprot_id": [ { "id": "UBP4_MOUSE", "url": "https://www.uniprot.org/uniprot/P35123", "type": "external" } ], "mass": 108343.0, "length": 962, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 4", "gene_name": "Usp4", "organism": "Mouse", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 4 isoform 1", "refseq_ac": [ { "id": "NP_035808", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035808", "type": "external" } ], "gene_names_uniprotkb": "Usp4; Unp", "gene_names_refseq": "F730026I20Rik; Unp; Usp4; mKIAA4155", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 4; 3.4.19.12; Deubiquitinating enzyme 4; Ubiquitin thioesterase 4; Ubiquitin-specific-processing protease 4; Ubiquitous nuclear protein", "protein_names_refseq": "deubiquitinating enzyme 4; ubiquitin carboxyl-terminal hydrolase 4 isoform 1; ubiquitin carboxyl-terminal hydrolase 4; ubiquitin specific peptidase 4 (proto-oncogene); ubiquitin specific protease 4 (proto-oncogene); ubiquitin thioesterase 4; ubiquitin thiolesterase 4; ubiquitin-specific-processing protease 4; ubiquitous nuclear protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:22258); (R-MMU-5357786); (R-MMU-5357905); (R-MMU-5357956); (R-MMU-5689880)", "pathway_count": 5, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;11571651;15494318;21183079;21750661;25153642;26503449;26740625;28528544;34144056;34428180;38134227;39266638;39927985;8336951;9602026", "class_list": "", "function": "Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes., [UniProtKB, UniProtKB]; Deubiquitinating enzyme that removes conjugated ubiquitin from target proteins (By similarity). Deubiquitinates PDPK1 (By similarity). Deubiquitinates TRIM21 (By similarity). Deubiquitinates receptor ADORA2A which increases the amount of functional receptor at the cell surface (By similarity). Deubiquitinates HAS2 (By similarity). Deubiquitinates RHEB in response to EGF signaling, promoting mTORC1 signaling (By similarity). Deubiquitinates MAVS leading to maintain MAVS protein stability, resulting in increased production of type I interferons (IFN-I) and enhanced antiviral innate immune responses against viral infections (By similarity). May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3 (By similarity). This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6.U5 snRNP (By similarity). May also play a role in the regulation of quality control in the ER (By similarity)., [UniProtKB, UniProtKB]; Deubiquitinating enzyme that removes conjugated ubiquitin from target proteins. Deubiquitinates PDPK1. Deubiquitinates TRIM21. Deubiquitinates receptor ADORA2A which increases the amount of functional receptor at the cell surface. Deubiquitinates HAS2. Deubiquitinates RHEB in response to EGF signaling, promoting mTORC1 signaling. Deubiquitinates MAVS leading to maintain MAVS protein stability, resulting in increased production of type I interferons (IFN-I) and enhanced antiviral innate immune responses against viral infections. May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3. This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6.U5 snRNP. May also play a role in the regulation of quality control in the ER., [UniProtKB, UniProtKB]; FBXO3 stabilizes USP4 and Twist1 to promote PI3K-mediated breast cancer metastasis. Publication Status: Online-Only, [RefSeq, PubMed]; USP4 is pathogenic in allergic airway inflammation by inhibiting regulatory T cell response., [RefSeq, PubMed]; USP4 regulates ribosome biogenesis and protein synthesis for hematopoietic stem cell regeneration and leukemia progression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O54704;Q8BTL9", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0031685 adenosine receptor binding;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0000244 spliceosomal tri-snRNP complex assembly;GO:0031647 regulation of protein stability", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P35123-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62257-1", "uniprot_id": [ { "id": "UBE2H_MOUSE", "url": "https://www.uniprot.org/uniprot/P62257", "type": "external" } ], "mass": 20655.0, "length": 183, "protein_name": "Ubiquitin-conjugating enzyme E2 H", "gene_name": "Ube2h", "organism": "Mouse", "refseq_name": "ubiquitin-conjugating enzyme E2 H isoform 1", "refseq_ac": [ { "id": "NP_033485", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033485", "type": "external" } ], "gene_names_uniprotkb": "Ube2h", "gene_names_refseq": "1500009C23Rik; E2-20K; Gid3; Ubc8; Ube2h", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 H; (E3-independent) E2 ubiquitin-conjugating enzyme H; 2.3.2.23; 2.3.2.24; E2 ubiquitin-conjugating enzyme H; UBCH2; Ubiquitin carrier protein H; Ubiquitin-conjugating enzyme E2-20K; Ubiquitin-protein ligase H", "protein_names_refseq": "(E3-independent) E2 ubiquitin-conjugating enzyme H; E2 ubiquitin-conjugating enzyme H; UBCH2; ubiquitin carrier protein H; ubiquitin-conjugating enzyme E2 H isoform 1; ubiquitin-conjugating enzyme E2-20K; ubiquitin-protein ligase H", "tax_id": 10090, "disease": "viral infectious disease (Disease Ontology:DOID:934)", "pathway": " (mmu:22214); (R-MMU-8866652); (R-MMU-983168)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "21750661;22872234;23806337;23965929;31219806;34428180;36210013;7590289;7761435", "class_list": "", "function": "Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. E2 ubiquitin conjugating enzyme that transfers ubiquitin to MAEA, a core component of the CTLH E3 ubiquitin-protein ligase complex. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; MG53 is an ubiquitin E3 ligase that induces IRS-1 ubiquitination with the help of an E2-conjugating enzyme, UBE2H., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P37286", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "6.2.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.64", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004842 ubiquitin-protein transferase activity;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0070979 protein K11-linked ubiquitination;GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0070936 protein K48-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P62257-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0KK59-1", "uniprot_id": [ { "id": "UNC79_MOUSE", "url": "https://www.uniprot.org/uniprot/Q0KK59", "type": "external" } ], "mass": 290740.0, "length": 2596, "protein_name": "Protein unc-79 homolog", "gene_name": "Unc79", "organism": "Mouse", "refseq_name": "protein unc-79 homolog", "refseq_ac": [ { "id": "NP_001074486", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074486", "type": "external" } ], "gene_names_uniprotkb": "Unc79; Kiaa1409", "gene_names_refseq": "9030205A07Rik; Mlca3; Unc79", "protein_names_uniprotkb": "Protein unc-79 homolog", "protein_names_refseq": "modifier of locomotor activity 3; protein unc-79 homolog", "tax_id": 10090, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:217843); (R-MMU-2672351)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;14680840;16807365;20714347;21040849;21183079;21750661;31219806;32620897;34203471", "class_list": "", "function": "Auxilary subunit of the NALCN channelosome complex, which regulates the resting membrane potential by depolarizing sodium leak currents (By similarity). The NALCN channelosome complex is a voltage-gated ion channel responsible for the resting Na(+) permeability that controls neuronal excitability (By similarity). The NALCN channelosome is constitutively active and conducts monovalent cations but is blocked by physiological concentrations of extracellular divalent cations (By similarity). Activated by neuropeptides substance P, neurotensin, and extracellular Ca(2+) that regulates neuronal excitability by controlling the sizes of NALCN-dependent sodium-leak current (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Therefore, extracellular Ca(2+) influences neuronal excitability through the UNC79-unc-80 homolog (C. elegans) protein unc-80-non-selective protein voltage gated channel like 1 complex in a G protein-dependent fashion, [RefSeq, PubMed]; Unc-79 mutanted mouse consume more ethanol than wild-type littermates. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9545, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q0KK54;Q6L9U9;Q8CCC5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0001518 voltage-gated sodium channel complex", "go_biological_process": "GO:0001967 suckling behavior;GO:0030534 adult behavior;GO:0048149 behavioral response to ethanol;GO:0035264 multicellular organism growth;GO:0035725 sodium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q0KK59-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ES00-1", "uniprot_id": [ { "id": "UBE4B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ES00", "type": "external" } ], "mass": 133318.0, "length": 1173, "protein_name": "Ubiquitin conjugation factor E4 B", "gene_name": "Ube4b", "organism": "Mouse", "refseq_name": "ubiquitin conjugation factor E4 B isoform 1", "refseq_ac": [ { "id": "NP_071305", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071305", "type": "external" } ], "gene_names_uniprotkb": "Ube4b; Ufd2a; Ufd2", "gene_names_refseq": "4930551I19Rik; 4933406G05Rik; D4Bwg0973e; UFD2a; UFD2; Ube4b; Ufd2p; mKIAA0684", "protein_names_uniprotkb": "Ubiquitin conjugation factor E4 B; 2.3.2.27; RING-type E3 ubiquitin transferase E4 B; Ubiquitin fusion degradation protein 2", "protein_names_refseq": "RING-type E3 ubiquitin transferase E4 B; ubiquitin conjugation factor E4 B isoform 1; ubiquitin conjugation factor E4 B; ubiquitin fusion degradation protein 2; ubiquitination factor E4B, UFD2 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:63958)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "11027338;11435423;11770485;12504083;15345747;17242355;21183079;21750661;25428506;25605945;30084848;34428180;36440598;36852467;39627609", "class_list": "", "function": "Fine-tuning of mTOR signaling by the UBE4B-KLHL22 E3 ubiquitin ligase cascade in brain development., [RefSeq, PubMed]; Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. Also functions as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6DID4;Q9EQE0", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0051082 unfolded protein binding;GO:0051117 ATPase binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0031175 neuron projection development;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0006457 protein folding;GO:0009411 response to UV;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9ES00-1", "record_type": "protein", "filter_code": "0000000.1100101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8QZY6-1", "uniprot_id": [ { "id": "TSN14_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8QZY6", "type": "external" } ], "mass": 30674.0, "length": 270, "protein_name": "Tetraspanin-14", "gene_name": "Tspan14", "organism": "Mouse", "refseq_name": "tetraspanin-14", "refseq_ac": [ { "id": "NP_001303677", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001303677", "type": "external" } ], "gene_names_uniprotkb": "Tspan14; D14Ertd226e; Tm4sf14", "gene_names_refseq": "D14Ertd226e; Tm4sf14; Tspan14; tspan-14", "protein_names_uniprotkb": "Tetraspanin-14; Transmembrane 4 superfamily member 14; Tspan-14", "protein_names_refseq": "tetraspanin-14; transmembrane 4 superfamily member 14", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:52588); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "23035126;26668317;32152506", "class_list": "", "function": "Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates (PubMed:23035126, PubMed:26668317). Negatively regulates ADAM10-mediated cleavage of GP6 (PubMed:26668317). Promotes ADAM10-mediated cleavage of CDH5 (PubMed:23035126)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0097197 tetraspanin-enriched microdomain", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0045747 positive regulation of Notch signaling pathway;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8QZY6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R317-1", "uniprot_id": [ { "id": "UBQL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R317", "type": "external" } ], "mass": 61976.0, "length": 582, "protein_name": "Ubiquilin-1", "gene_name": "Ubqln1", "organism": "Mouse", "refseq_name": "ubiquilin-1 isoform 1", "refseq_ac": [ { "id": "NP_081118", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081118", "type": "external" } ], "gene_names_uniprotkb": "Ubqln1; Plic1", "gene_names_refseq": "1110046H03Rik; 1810030E05Rik; D13Ertd372e; Da41; Dsk2; Plic-1; Plic1; Ubqln1; Xdrp1", "protein_names_uniprotkb": "Ubiquilin-1; PLIC-1; Protein linking IAP with cytoskeleton 1", "protein_names_refseq": "protein linking IAP with cytoskeleton 1; ubiquilin-1 isoform 1", "tax_id": 10090, "disease": "amyotrophic lateral sclerosis type 15 (Disease Ontology:DOID:0060206); neurodegenerative disease (Disease Ontology:DOID:1289); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); frontotemporal dementia (Disease Ontology:DOID:9255)", "pathway": " (mmu:56085); (R-MMU-8856825)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "10549293;15004330;18299400;19148225;20529957;21750661;21952136;25428506;26495903;30084848;33300544;33725478;34428180;35820727;37014234;37463174;39159700;39927985;40997131", "class_list": "", "function": "Described results suggest that ubiquilin proteins play an important role in regulating presenilin 2 (PS2) protein levels in cells., [RefSeq, PubMed]; Hepatocyte CD36 modulates UBQLN1-mediated proteasomal degradation of autophagic SNARE proteins contributing to septic liver injury., [RefSeq, PubMed]; Plays a role in unfolded protein response (UPR) by attenuating the induction of UPR-inducible genes, DDTI3/CHOP, HSPA5 and PDIA2 during ER stress., [UniProtKB, UniProtKB]; Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome. Plays a role in the ERAD pathway via its interaction with ER-localized proteins UBXN4, VCP and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome. Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion. Negatively regulates the TICAM1/TRIF-dependent toll-like receptor signaling pathway by decreasing the abundance of TICAM1 via the autophagic pathway. Promotes the ubiquitination and lysosomal degradation of ORAI1, consequently down-regulating the ORAI1-mediated Ca2+ mobilization. Suppresses the maturation and proteasomal degradation of amyloid beta A4 protein (A4) by stimulating the lysine 63 (K63)-linked polyubiquitination. Delays the maturation of A4 by sequestering it in the Golgi apparatus and preventing its transport to the cell surface for subsequent processing (By similarity). Links CD47 to the cytoskeleton (PubMed:10549293). Ubiquitinates BCL2L10 and thereby stabilizes protein abundance (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Sec13 promotes glycolysis by inhibiting Ubqln1 mediated Pgm1 ubiquitination in ALI., [RefSeq, PubMed]; UBQLN1 deficiency mediates telomere shortening and IPF through interacting with RPA1. Publication Status: Online-Only, [RefSeq, PubMed]; UBQLN1-transfected cells did not show increased starvation-induced cell death, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80V10;Q8C7T4;Q8C835;Q8K141;Q91VI8;Q9D0Z0;Q9QZM1", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0019904 protein domain specific binding;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0042802 identical protein binding;GO:0019900 kinase binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0000045 autophagosome assembly;GO:0016241 regulation of macroautophagy;GO:0071456 cellular response to hypoxia;GO:0031398 positive regulation of protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q8R317-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q922Y1-1", "uniprot_id": [ { "id": "UBXN1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q922Y1", "type": "external" } ], "mass": 33573.0, "length": 297, "protein_name": "UBX domain-containing protein 1", "gene_name": "Ubxn1", "organism": "Mouse", "refseq_name": "UBX domain-containing protein 1", "refseq_ac": [ { "id": "NP_666205", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666205", "type": "external" } ], "gene_names_uniprotkb": "Ubxn1; D19Ertd721e; Saks1", "gene_names_refseq": "2B28; 4930455J02Rik; D19Ertd721e; Ubxn1; mY33K", "protein_names_uniprotkb": "UBX domain-containing protein 1; Protein 2B28; SAPK substrate protein 1; UBA/UBX 33.3 kDa protein; mY33K", "protein_names_refseq": "SAPK substrate protein 1; UBA/UBX 33.3 kDa protein; UBX domain-containing protein 1; protein 2B28", "tax_id": 10090, "disease": "", "pathway": " (mmu:225896); (R-MMU-532668); (R-MMU-5693565)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "11562482;15345747;15944415;16075062;16709668;17242355;21183079;21750661;22517741;22645316;26495903;28528544;36288343;38773518", "class_list": "", "function": "Specific interaction of rat protein 2B28 with rat Homer2 may play a role in regulation of protein degradation by ubiquitin-proteasome systems and that this function may be specific to Homer2 proteins among Homer family proteins., [RefSeq, PubMed]; UBXN1 promotes liver tumorigenesis by regulating mitochondrial homeostasis. Publication Status: Online-Only, [RefSeq, PubMed]; Ubiquitin-binding protein that plays a role in the modulation of innate immune response. Blocks both the RIG-I-like receptors (RLR) and NF-kappa-B pathways. Following viral infection, UBXN1 is induced and recruited to the RLR component MAVS. In turn, interferes with MAVS oligomerization, and disrupts the MAVS/TRAF3/TRAF6 signalosome. This function probably serves as a brake to prevent excessive RLR signaling. Interferes with the TNFalpha-triggered NF-kappa-B pathway by interacting with cellular inhibitors of apoptosis proteins (cIAPs) and thereby inhibiting their recruitment to TNFR1. Also prevents the activation of NF-kappa-B by associating with CUL1 and thus inhibiting NF-kappa-B inhibitor alpha/NFKBIA degradation that remains bound to NF-kappa-B. Interacts with the BRCA1-BARD1 heterodimer and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1 leads to the inhibition of the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UCP8", "ec_number_list": [], "go_molecular_function": "GO:0036435 K48-linked polyubiquitin modification-dependent protein binding;GO:0071796 K6-linked polyubiquitin modification-dependent protein binding;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0051117 ATPase binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0031397 negative regulation of protein ubiquitination;GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:1904293 negative regulation of ERAD pathway;GO:1903094 negative regulation of protein K48-linked deubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q922Y1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q925K9-1", "uniprot_id": [ { "id": "TSSK6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q925K9", "type": "external" } ], "mass": 30287.0, "length": 273, "protein_name": "Testis-specific serine/threonine-protein kinase 6", "gene_name": "Tssk6", "organism": "Mouse", "refseq_name": "testis-specific serine/threonine-protein kinase 6", "refseq_ac": [ { "id": "NP_114393", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114393", "type": "external" } ], "gene_names_uniprotkb": "Tssk6; Sstk", "gene_names_refseq": "Sstk; TSK-6; TSSK-6; Tssk6", "protein_names_uniprotkb": "Testis-specific serine/threonine-protein kinase 6; 2.7.11.1; Serine/threonine-protein kinase SSTK; Small serine/threonine kinase; TSK-6; TSSK-6; Testis-specific kinase 6", "protein_names_refseq": "serine/threonine protein kinase SSTK; small serine/threonine kinase; testis-specific kinase 6; testis-specific serine/threonine-protein kinase 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:83984)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15870294;20829357;23599433;28389581;37295417", "class_list": "", "function": "HSP90 function abolished the catalytic activities of TSSK4 and -6 but did not significantly alter the specific activities of TSSK1 and -2. Inhibition of HSP90 resulted in increased TSSK ubiquitination and proteasomal degradation, [RefSeq, PubMed]; HSP90 is essential for functional maturation of the kinase and identify SIP as a cochaperone that is critical to the HSP90-mediated activation of SSTK., [RefSeq, PubMed]; Results demonstrate that SSTK is required for proper postmeiotic chromatin remodeling and male fertility, [RefSeq, PubMed]; Serine/threonine-protein kinase component of the sperm flagellar doublet microtubules (PubMed:15870294, PubMed:37295417). May act as a regulator of sperm motility by mediating phosphorylation of sperm doublet microtubule proteins (PubMed:37295417). Plays a role in DNA condensation during postmeiotic chromatin remodeling and histone-to-protamine transition during spermatogenesis (PubMed:15870294, PubMed:28389581)., [UniProtKB, PubMed, PubMed, PubMed]; TSSK6 is required for gammaH2AX formation during spermiogenesis, and also link gammaH2AX to the histone-to-protamine transition and male fertility., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5RL09;Q8C625", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0044877 protein-containing complex binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0036126 sperm flagellum;GO:0160110 axonemal microtubule doublet inner sheath", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0030317 flagellated sperm motility;GO:0007286 spermatid development;GO:0035092 sperm DNA condensation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q925K9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JMH6-1", "uniprot_id": [ { "id": "TRXR1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JMH6", "type": "external" } ], "mass": 67084.0, "length": 613, "protein_name": "Thioredoxin reductase 1, cytoplasmic", "gene_name": "Txnrd1", "organism": "Mouse", "refseq_name": "thioredoxin reductase 1, cytoplasmic isoform 1", "refseq_ac": [ { "id": "NP_001035978", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035978", "type": "external" } ], "gene_names_uniprotkb": "Txnrd1; Trxr1", "gene_names_refseq": "TR1; TR; TrxR1; Txnrd1", "protein_names_uniprotkb": "Thioredoxin reductase 1, cytoplasmic; 1.11.1.2; 1.8.1.9; Peroxidase TXNRD1; TR; Thioredoxin reductase TR1", "protein_names_refseq": "TR alpha; peroxidase TXNRD1; thioredoxin reductase 1, cytoplasmic isoform 1; thioredoxin reductase 1, cytoplasmic; thioredoxin reductase TR1", "tax_id": 10090, "disease": "amyotrophic lateral sclerosis (Disease Ontology:DOID:332); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (mmu:50493); (R-MMU-3299685); (R-MMU-499943); (R-MMU-5263617); (R-MMU-5628897)", "pathway_count": 5, "publication_count": 17, "publication_id_list": "10721726;11060283;11737861;15592455;21750661;22645316;23806337;24788674;25428506;28528544;31219806;31599954;34428180;37453647;37828378;39059206;39927985", "class_list": "", "function": "Reduces disulfide protein thioredoxin (Trx) to its dithiol-containing form. Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation. A selenocysteine residue at the C-terminal active site is essential for catalysis. Also has reductase activity on hydrogen peroxide (H2O2)., [UniProtKB, UniProtKB]; The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing, primarily at the 5' end, results in transcript variants encoding same or different isoforms. [provided by RefSeq, May 2017]., [RefSeq]; TrxR1 is involved in the activation of Caspase-11 by regulating the oxidative-reductive status of Trx-1., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3UEB7;Q3UK84;Q8CI31;Q99P49;Q9CSV5", "ec_number_list": [ { "id": "1.8.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.9", "type": "external" }, { "id": "1.11.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.2", "type": "external" } ], "go_molecular_function": "GO:0004791 thioredoxin-disulfide reductase (NADPH) activity;GO:0042802 identical protein binding;GO:0071949 FAD binding;GO:0016174 NAD(P)H oxidase H2O2-forming activity;GO:0045340 mercury ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0008283 cell population proliferation;GO:0043065 positive regulation of apoptotic process;GO:0045454 cell redox homeostasis;GO:0001707 mesoderm formation", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9JMH6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZM0-1", "uniprot_id": [ { "id": "UBQL2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QZM0", "type": "external" } ], "mass": 67351.0, "length": 638, "protein_name": "Ubiquilin-2", "gene_name": "Ubqln2", "organism": "Mouse", "refseq_name": "ubiquilin-2", "refseq_ac": [ { "id": "NP_061268", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061268", "type": "external" } ], "gene_names_uniprotkb": "Ubqln2; Plic2", "gene_names_refseq": "Chap1; Dsk2; HRIHFB2157; Plic-2; Plic2; Ubqln2", "protein_names_uniprotkb": "Ubiquilin-2; Chap1; DSK2 homolog; PLIC-2; Protein linking IAP with cytoskeleton 2; Ubiquitin-like product Chap1/Dsk2", "protein_names_refseq": "Ubiquitin-related protein; protein linking IAP with cytoskeleton 2; ubiquilin-2; ubiquitin-like product Chap1/Dsk2", "tax_id": 10090, "disease": "amyotrophic lateral sclerosis type 15 (Disease Ontology:DOID:0060206); neurodegenerative disease (Disease Ontology:DOID:1289); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); frontotemporal dementia (Disease Ontology:DOID:9255)", "pathway": " (mmu:54609); (R-MMU-8856825)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "10549293;15345747;16075062;17114649;20665223;25428506;26495903;29125738;30084848;32782141;33300544;33725478;33991504;34678516;35082119;36288343;36609661;39627609;39927985;40997131", "class_list": "", "function": "Disrupting the Balance of Protein Quality Control Protein UBQLN2 Accelerates Tau Proteinopathy., [RefSeq, PubMed]; Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome. Plays a role in the ERAD pathway via its interaction with ER-localized proteins FAF2/UBXD8 and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome. Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion. Negatively regulates the endocytosis of GPCR receptors: AVPR2 and ADRB2, by specifically reducing the rate at which receptor-arrestin complexes concentrate in clathrin-coated pits (CCPs) (By similarity). Links CD47 to vimentin-containing intermediate filaments of the cytoskeleton (PubMed:10549293)., [UniProtKB, UniProtKB, PubMed]; UBQLN2-HSP70 axis reduces poly-Gly-Ala aggregates and alleviates behavioral defects in the C9ORF72 animal model., [RefSeq, PubMed]; Ubiquilin-2 regulates pathological alpha-synuclein. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 16, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 16, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 16, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 16, "binding_glycan_count": 0, "secondary_ac_list": "B1AY62;Q7TSJ8;Q8VDH9", "ec_number_list": [], "go_molecular_function": "GO:0031593 polyubiquitin modification-dependent protein binding;GO:0042802 identical protein binding;GO:0140693 molecular condensate scaffold activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0016241 regulation of macroautophagy;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0036503 ERAD pathway;GO:1904294 positive regulation of ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "Q9QZM0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VEE6-1", "uniprot_id": [ { "id": "ZN800_MOUSE", "url": "https://www.uniprot.org/uniprot/Q0VEE6", "type": "external" } ], "mass": 74813.0, "length": 662, "protein_name": "Zinc finger protein 800", "gene_name": "Zfp800; Znf800", "organism": "Mouse", "refseq_name": "zinc finger protein 800 isoform a", "refseq_ac": [ { "id": "NP_001075147", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075147", "type": "external" } ], "gene_names_uniprotkb": "Zfp800; Znf800; Zfp800", "gene_names_refseq": "Zfp800; Znf800", "protein_names_uniprotkb": "Zinc finger protein 800", "protein_names_refseq": "zinc finger protein 800 isoform a", "tax_id": 10090, "disease": "", "pathway": " (mmu:627049)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17242355;21183079;21750661;31219806;33653874;34428180;35820727", "class_list": "", "function": "A developmental lineage-based gene co-expression network for mouse pancreatic beta-cells reveals a role for Zfp800 in pancreas development. Publication Status: Online-Only, [RefSeq, PubMed]; DNA-binding transcription repressor that acts as a master repressor of enteroendocrine cell differentiation (By similarity). Acts upstream of the endocrine gene network and directly represses expression of enteroendocrine transcription factors, such as NEUROG3, INSM1 and SOX4 (By similarity). In the intestine, prevents enterochromaffin cell differentiation by repressing expression of PAX4, a transcription factor that drives differentiation of enterochromaffin cell and restricts differentiation of other intestinal enteroendocrine cell types (By similarity). Also involved in the differentiation and development of type B pancreatic cells (PubMed:33653874)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q0VEE6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61464-1", "uniprot_id": [ { "id": "ZN638_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61464", "type": "external" } ], "mass": 218134.0, "length": 1960, "protein_name": "Zinc finger protein 638", "gene_name": "Zfp638; Znf638", "organism": "Mouse", "refseq_name": "zinc finger protein 638 isoform 2", "refseq_ac": [ { "id": "NP_001159843", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159843", "type": "external" } ], "gene_names_uniprotkb": "Zfp638; Znf638; Np220; Zfml; Zfp638", "gene_names_refseq": "Np220; Zfml; Zfp638; Znf638; mNP220", "protein_names_uniprotkb": "Zinc finger protein 638; Nuclear protein 220; Zinc finger matrin-like protein", "protein_names_refseq": "nuclear protein 220; zinc finger matrin-like protein; zinc finger protein 638 isoform 2; zinc finger, matrin-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:18139)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21602272;21750661;24788674;25024404;25428506;30487602;31219806;33040080;34428180;38211696;40885482;8670298", "class_list": "", "function": "Transcription factor that binds to cytidine clusters in double-stranded DNA (By similarity). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (PubMed:21602272). May also regulate alternative splicing of target genes during adipogenesis (PubMed:25024404)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; USP7 mediates pathological hepatic de novo lipogenesis through promoting stabilization and transcription of ZNF638. Publication Status: Online-Only, [RefSeq, PubMed]; Zinc finger protein ZNF638 regulates triglyceride metabolism via ANGPTL8 in an estrogen dependent manner., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q6DFV9;Q8C941", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003729 mRNA binding;GO:0008270 zinc ion binding;GO:0003723 RNA binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0008380 RNA splicing;GO:0043484 regulation of RNA splicing", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q61464-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61624-1", "uniprot_id": [ { "id": "ZN148_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61624", "type": "external" } ], "mass": 88751.0, "length": 794, "protein_name": "Zinc finger protein 148", "gene_name": "Zfp148; Znf148", "organism": "Mouse", "refseq_name": "zinc finger protein 148", "refseq_ac": [ { "id": "NP_035879", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035879", "type": "external" } ], "gene_names_uniprotkb": "Zfp148; Znf148; Zbp89; Zfp148", "gene_names_refseq": "2210405J08Rik; BERF-1; BFCOL1; ZBP-89; Zfp148; Znf148", "protein_names_uniprotkb": "Zinc finger protein 148; Beta enolase repressor factor 1; G-rich box-binding protein; Transcription factor BFCOL1; Transcription factor ZBP-89; Zinc finger DNA-binding protein 89", "protein_names_refseq": "G-rich box-binding protein; beta enolase repressor factor 1; transcription factor BFCOL1; transcription factor ZBP-89; zinc finger DNA-binding protein 89; zinc finger protein 148", "tax_id": 10090, "disease": "", "pathway": " (mmu:22661)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10727401;17242355;21183079;21750661;22872859;25428506;31219806;34105348;35603790;36710662;37948511;40997131;8943318;9030551;9417107", "class_list": "", "function": "Beta Cell-specific deletion of Zfp148 improves nutrient-stimulated beta cell Ca2+ responses. Publication Status: Online-Only, [RefSeq, PubMed]; Identification of the MALAT1/miR-106a-5p/ZNF148 feedback loop in regulating HaCaT cell proliferation, migration and apoptosis., [RefSeq, PubMed]; Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Zfp281 and Zfp148 control CD4[+] T cell thymic development and TH2 functions., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P97475", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q61624-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6ZPZ3-1", "uniprot_id": [ { "id": "ZC3H4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6ZPZ3", "type": "external" } ], "mass": 140967.0, "length": 1304, "protein_name": "Zinc finger CCCH domain-containing protein 4", "gene_name": "Zc3h4", "organism": "Mouse", "refseq_name": "zinc finger CCCH domain-containing protein 4 isoform 2", "refseq_ac": [ { "id": "NP_941033", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_941033", "type": "external" } ], "gene_names_uniprotkb": "Zc3h4; Kiaa1064", "gene_names_refseq": "Bwq1; Gm768; Kiaa1064-hp; Zc3h4", "protein_names_uniprotkb": "Zinc finger CCCH domain-containing protein 4", "protein_names_refseq": "zinc finger CCCH domain-containing protein 4 isoform 2; zinc finger CCCH domain-containing protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:330474); (R-MMU-9930044)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "17242355;21183079;21750661;24129315;33246328;33767452;34979141;35820727;37866415;37944732", "class_list": "", "function": "CircDYM attenuates microglial apoptosis via CEBPB/ZC3H4 axis in LPS-induced mouse model of depression., [RefSeq, PubMed]; RNA-binding protein that suppresses transcription of long non-coding RNAs (lncRNAs) (PubMed:33767452). LncRNAs are defined as transcripts more than 200 nucleotides that are not translated into protein (PubMed:33767452). Together with WDR82, part of a transcription termination checkpoint that promotes transcription termination of lncRNAs and their subsequent degradation by the exosome (PubMed:33767452). The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs (PubMed:33767452)., [UniProtKB, PubMed]; RNA-binding protein that suppresses transcription of long non-coding RNAs (lncRNAs). LncRNAs are defined as transcripts more than 200 nucleotides that are not translated into protein. Together with WDR82, part of a transcription termination checkpoint that promotes transcription termination of lncRNAs and their subsequent degradation by the exosome. The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs., [UniProtKB, UniProtKB, UniProtKB]; ZC3H4 governs epithelial cell migration through ROCK/p-PYK2/p-MLC2 pathway in silica-induced pulmonary fibrosis., [RefSeq, PubMed]; ZC3H4 promotes pulmonary fibrosis via an ER stress-related positive feedback loop., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:1990841 promoter-specific chromatin binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005694 chromosome;GO:0005634 nucleus", "go_biological_process": "GO:0032785 negative regulation of DNA-templated transcription, elongation;GO:0006353 DNA-templated transcription termination;GO:0071027 nuclear RNA surveillance;GO:0110064 lncRNA catabolic process;GO:0140744 negative regulation of lncRNA transcription", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q6ZPZ3-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63932-1", "uniprot_id": [ { "id": "MP2K2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q63932", "type": "external" } ], "mass": 44402.0, "length": 401, "protein_name": "Dual specificity mitogen-activated protein kinase kinase 2", "gene_name": "Map2k2", "organism": "Mouse", "refseq_name": "dual specificity mitogen-activated protein kinase kinase 2 isoform 1", "refseq_ac": [ { "id": "NP_075627", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075627", "type": "external" } ], "gene_names_uniprotkb": "Map2k2; Mek2; Mkk2; Prkmk2", "gene_names_refseq": "MEK2; MK2; Map2k2; Prkmk2", "protein_names_uniprotkb": "Dual specificity mitogen-activated protein kinase kinase 2; 2.7.12.2; ERK activator kinase 2; MAP kinase kinase 2; MAPK/ERK kinase 2; MAPKK 2; MEK 2", "protein_names_refseq": "ERK activator kinase 2; MAP kinase kinase 2; MAP kinase/Erk kinase; MAPK/ERK kinase 2; MAPKK 2; MEK 2; dual specificity mitogen-activated protein kinase kinase 2 isoform 1; dual specificity mitogen-activated protein kinase kinase 2; protein kinase, mitogen activated, kinase 2, p45", "tax_id": 10090, "disease": "RASopathy (Disease Ontology:DOID:0080690); cardiofaciocutaneous syndrome 4 (Disease Ontology:DOID:0111463); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); glioblastoma (Disease Ontology:DOID:3068); small intestine adenocarcinoma (Disease Ontology:DOID:4906); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:26396); (R-MMU-112411); (R-MMU-170968); (R-MMU-445144); (R-MMU-5673000); (R-MMU-5674135); (R-MMU-5674499)", "pathway_count": 7, "publication_count": 8, "publication_id_list": "10409742;1381507;15118098;19219045;21750661;28225038;34428180;8297798", "class_list": "", "function": "Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (PubMed:19219045). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9D7B0", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005769 early endosome", "go_biological_process": "GO:2000641 regulation of early endosome to late endosome transport;GO:0030878 thyroid gland development;GO:0048679 regulation of axon regeneration;GO:0002931 response to ischemia;GO:0006468 protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q63932-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PZQ0-1", "uniprot_id": [ { "id": "RYR1_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PZQ0", "type": "external" } ], "mass": 565039.0, "length": 5035, "protein_name": "Ryanodine receptor 1", "gene_name": "Ryr1", "organism": "Mouse", "refseq_name": "ryanodine receptor 1", "refseq_ac": [ { "id": "NP_033135", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033135", "type": "external" } ], "gene_names_uniprotkb": "Ryr1", "gene_names_refseq": "RYR-1; Ryr1; Ryr; skrr", "protein_names_uniprotkb": "Ryanodine receptor 1; RYR-1; RyR1; Skeletal muscle calcium release channel; Skeletal muscle ryanodine receptor; Skeletal muscle-type ryanodine receptor; Type 1 ryanodine receptor", "protein_names_refseq": "calcium release channel; ryanodine receptor 1; skeletal muscle calcium release channel; skeletal muscle ryanodine receptor; skeletal muscle-type ryanodine receptor; type 1 ryanodine receptor", "tax_id": 10090, "disease": "King Denborough syndrome (Disease Ontology:DOID:0080990); congenital myopathy 1B (Disease Ontology:DOID:0080991); pre-eclampsia (Disease Ontology:DOID:10591); gestational diabetes (Disease Ontology:DOID:11714); intracranial vasospasm (Disease Ontology:DOID:13100); primary pulmonary hypertension (Disease Ontology:DOID:14557); alcohol use disorder (Disease Ontology:DOID:1574); osteochondrodysplasia (Disease Ontology:DOID:2256); congenital myopathy 1A (Disease Ontology:DOID:3529); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); malignant hyperthermia (Disease Ontology:DOID:8545)", "pathway": " (mmu:20190); (R-MMU-2672351); (R-MMU-5578775)", "pathway_count": 3, "publication_count": 18, "publication_id_list": "18003898;18268335;20214899;21156754;21183079;21750661;22036948;23070698;25428506;35469018;38445312;38820626;39927985;7515481;7621815;7635066;7724570;7876312", "class_list": "", "function": "A novel, patient-derived RyR1 mutation impairs muscle function and calcium homeostasis in mice., [RefSeq, PubMed]; Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules (PubMed:18003898, PubMed:21156754, PubMed:7515481, PubMed:7621815). Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm (PubMed:18268335). Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain (PubMed:22036948). Required for normal embryonic development of muscle fibers and skeletal muscle (PubMed:7515481). Required for normal heart morphogenesis, skin development and ossification during embryogenesis (PubMed:18003898, PubMed:7515481)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Physiological role for S-nitrosylation of RyR1 in skeletal muscle function and development., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 13, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q60834;Q61779;Q61780;Q62173;Q62196;Q62235;Q78EJ6;Q7TNG1;Q80UQ5;Q80X16;Q99JF9", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0002020 protease binding;GO:0005262 calcium channel activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005790 smooth endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0016020 membrane", "go_biological_process": "GO:0043931 ossification involved in bone maturation;GO:0006936 muscle contraction;GO:0051289 protein homotetramerization;GO:0001666 response to hypoxia;GO:0006816 calcium ion transport", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "E9PZQ0-1", "record_type": "protein", "filter_code": "0000000.1100111.000100.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60644-1", "uniprot_id": [ { "id": "NR1H2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60644", "type": "external" } ], "mass": 49720.0, "length": 446, "protein_name": "Oxysterols receptor LXR-beta", "gene_name": "Nr1h2", "organism": "Mouse", "refseq_name": "oxysterols receptor LXR-beta isoform a", "refseq_ac": [ { "id": "NP_001272446", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001272446", "type": "external" } ], "gene_names_uniprotkb": "Nr1h2; Lxrb; Rip15; Unr2; Unr", "gene_names_refseq": "LXRBSV; LXRB; LXRbeta; LXR; NER1; Nr1h2; OR-1; RIP15; UR; Unr2; Unr", "protein_names_uniprotkb": "Oxysterols receptor LXR-beta; Liver X receptor beta; Nuclear receptor subfamily 1 group H member 2; Retinoid X receptor-interacting protein No.15; Ubiquitously-expressed nuclear receptor", "protein_names_refseq": "LXR beta; liver X receptor beta; oxysterols receptor LXR-beta isoform a; oxysterols receptor LXR-beta; retinoid X receptor-interacting protein No.15; ubiquitously-expressed nuclear receptor 2", "tax_id": 10090, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:22260); (R-MMU-383280); (R-MMU-4090294); (R-MMU-8866427); (R-MMU-9029569); (R-MMU-9623433)", "pathway_count": 6, "publication_count": 12, "publication_id_list": "10675617;18055760;19520913;20427281;21750661;24206663;25724563;25806685;28661453;28846071;39125645;7760852", "class_list": "", "function": "Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:18055760, PubMed:19520913, PubMed:20427281). Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4) (PubMed:18055760, PubMed:19520913, PubMed:20427281). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8 (PubMed:18055760, PubMed:19520913, PubMed:20427281). Interplays functionally with RORA for the regulation of genes involved in liver metabolism (PubMed:18055760, PubMed:19520913, PubMed:20427281, PubMed:24206663, PubMed:28846071). Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis (PubMed:25806685, PubMed:28846071). Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles (PubMed:25806685). Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators (PubMed:24206663). Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; The Regulation of Frontal Cortex Cholesterol Metabolism Abnormalities by NR3C1/NRIP1/NR1H2 Is Involved in the Occurrence of Stress-Induced Depression. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0034191 apolipoprotein A-I receptor binding;GO:0051117 ATPase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0048550 negative regulation of pinocytosis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006629 lipid metabolic process;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q60644-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2B5-1", "uniprot_id": [ { "id": "E2AK3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z2B5", "type": "external" } ], "mass": 124682.0, "length": 1114, "protein_name": "Eukaryotic translation initiation factor 2-alpha kinase 3", "gene_name": "Eif2ak3", "organism": "Mouse", "refseq_name": "eukaryotic translation initiation factor 2-alpha kinase 3 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001300847", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001300847", "type": "external" } ], "gene_names_uniprotkb": "Eif2ak3; Pek; Perk", "gene_names_refseq": "Eif2ak3; Pek; Perk", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 2-alpha kinase 3; 2.7.10.2; 2.7.11.1; PRKR-like endoplasmic reticulum kinase; Pancreatic eIF2-alpha kinase; Protein tyrosine kinase EIF2AK3", "protein_names_refseq": "PRKR-like endoplasmic reticulum kinase; eukaryotic translation initiation factor 2-alpha kinase 3 isoform 2 precursor; pancreatic eIF2-alpha kinase; protein tyrosine kinase EIF2AK3", "tax_id": 10090, "disease": "Wolcott-Rallison syndrome (Disease Ontology:DOID:0090060); pulmonary venoocclusive disease (Disease Ontology:DOID:5453); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:13666); (R-MMU-381042)", "pathway_count": 2, "publication_count": 31, "publication_id_list": "10.1101/2023.09.13.557529;10854322;10882126;11035797;11106749;11430819;11997520;12446838;14517290;14978030;16418533;17998206;21543844;21750661;21954288;22509299;23921556;24371088;25428506;25925385;26495903;29386355;29449538;31023583;32029570;32180905;32788341;32811828;34203471;34428180;9930704", "class_list": "", "function": "Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress, such as unfolded protein response (UPR) (PubMed:10882126, PubMed:11106749, PubMed:11430819, PubMed:11997520, PubMed:14978030, PubMed:16418533, PubMed:17998206, PubMed:21954288, PubMed:23921556, PubMed:9930704). Key effector of the integrated stress response (ISR) to unfolded proteins: EIF2AK3/PERK specifically recognizes and binds misfolded proteins, leading to its activation and EIF2S1/eIF-2-alpha phosphorylation (PubMed:11106749, PubMed:16418533, PubMed:17998206, PubMed:21954288, PubMed:23921556, PubMed:29386355, PubMed:9930704). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming (PubMed:10882126, PubMed:11106749, PubMed:11430819, PubMed:11997520, PubMed:23921556). The EIF2AK3/PERK-mediated unfolded protein response increases mitochondrial oxidative phosphorylation by promoting ATF4-mediated expression of COX7A2L/SCAF1, thereby increasing formation of respiratory chain supercomplexes (PubMed:31023583). In contrast to most subcellular compartments, mitochondria are protected from the EIF2AK3/PERK-mediated unfolded protein response due to EIF2AK3/PERK inhibition by ATAD3A at mitochondria-endoplasmic reticulum contact sites (By similarity). In addition to EIF2S1/eIF-2-alpha, also phosphorylates NFE2L2/NRF2 in response to stress, promoting release of NFE2L2/NRF2 from the BCR(KEAP1) complex, leading to nuclear accumulation and activation of NFE2L2/NRF2 (PubMed:14517290, PubMed:14978030). Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1) (PubMed:11035797). Involved in control of mitochondrial morphology and function (PubMed:23921556)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in a similar gene in human are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9CTK8;Q9CWT5", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0071074 eukaryotic initiation factor eIF2 binding;GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0070417 cellular response to cold;GO:1903788 positive regulation of glutathione biosynthetic process;GO:0032055 negative regulation of translation in response to stress;GO:0001525 angiogenesis;GO:0006468 protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "Q9Z2B5-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.1000000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K1I7-1", "uniprot_id": [ { "id": "WIPF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K1I7", "type": "external" } ], "mass": 50080.0, "length": 493, "protein_name": "WAS/WASL-interacting protein family member 1", "gene_name": "Wipf1", "organism": "Mouse", "refseq_name": "WAS/WASL-interacting protein family member 1", "refseq_ac": [ { "id": "NP_001276651", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276651", "type": "external" } ], "gene_names_uniprotkb": "Wipf1; Waspip; Wip", "gene_names_refseq": "D2Ertd120e; WIP; Waspip; Wipf1", "protein_names_uniprotkb": "WAS/WASL-interacting protein family member 1; WASP-interacting protein; Wiskott-Aldrich syndrome protein-interacting protein", "protein_names_refseq": "WAS/WASL-interacting protein family member 1; WASP interacting protein; Wiskott-Aldrich syndrome protein interacting protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:215280); (R-MMU-2029482); (R-MMU-5663213)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "12147689;12724353;19144319;19910490;21183079;21750661;24129315;25428506;26453379;26495903;26664784;30021160;34428180;36935496", "class_list": "", "function": "CLDN6 inhibits breast cancer metastasis through WIP-dependent actin cytoskeleton-mediated autophagy. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation (By similarity). Plays a role in the formation of cell ruffles., [UniProtKB, PubMed, PubMed]; These experiments identify WIP as a member of a signaling cascade comprised of Abl family kinases, mTORC1 and S6K, which regulates neuron development and specifically, neuritic branching and complexity. Publication Status: Online-Only, [RefSeq, PubMed]; WIP binding to actin, independent of its binding to WASp, is critical for actin cytoskeleton plasticity in B cells., [RefSeq, PubMed]; WIP participates in the actin reorganization that leads to ruffle formation., [RefSeq, PubMed]; WIPf1 deficiency results in defective B cell function. By regulating the cortical actin cytoskeleton, WIPf1 influences the function of CD19 as a general hub for PI3K signaling., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U0U8", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0017124 SH3 domain binding;GO:0008093 cytoskeletal anchor activity;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005884 actin filament;GO:0015629 actin cytoskeleton;GO:0031410 cytoplasmic vesicle;GO:0001726 ruffle;GO:0005737 cytoplasm", "go_biological_process": "GO:0051707 response to other organism;GO:0046827 positive regulation of protein export from nucleus;GO:0030036 actin cytoskeleton organization;GO:0030048 actin filament-based movement", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8K1I7-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54799-1", "uniprot_id": [ { "id": "NMBR_MOUSE", "url": "https://www.uniprot.org/uniprot/O54799", "type": "external" } ], "mass": 43623.0, "length": 390, "protein_name": "Neuromedin-B receptor", "gene_name": "Nmbr", "organism": "Mouse", "refseq_name": "neuromedin-B receptor", "refseq_ac": [ { "id": "NP_032729", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032729", "type": "external" } ], "gene_names_uniprotkb": "Nmbr", "gene_names_refseq": "Nmbr", "protein_names_uniprotkb": "Neuromedin-B receptor; NMB-R; Neuromedin-B-preferring bombesin receptor", "protein_names_refseq": "NMB-R; neuromedin-B receptor; neuromedin-B-preferring bombesin receptor", "tax_id": 10090, "disease": "", "pathway": " (mmu:18101); (R-MMU-375276); (R-MMU-416476)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "11803457;21183079;21750661;26855425;28780306;30734045;31601264;34133943;35068177;9262170", "class_list": "", "function": "Disruption of neuromedin B receptor improves mitochondrial oxidative phosphorylation capacity in gastrocnemius muscle of female mice., [RefSeq, PubMed]; NMB-R-deficient mice exhibited decreased behavior in both the L-D box and elevated plus maze tests., [RefSeq, PubMed]; NMB-treated mice were less susceptible to virus challenge, as evidenced by increased survival, increased body weight, and decreased viral NP expression compared with the control animals. As expected, opposing effects were observed in the NMBR antagonist-treated cells and mice, which further confirmed the effects of NMB. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for neuromedin-B (By similarity). Contributes to the maintenance of basal sigh rate through signaling in the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (PubMed:26855425). Contributes to the induction of sneezing following exposure to chemical irritants or allergens which causes release of NMB by nasal sensory neurons and activation of NMBR-expressing neurons in the sneeze-evoking region of the brainstem (PubMed:34133943). These in turn activate neurons of the caudal ventral respiratory group, giving rise to the sneezing response (PubMed:34133943). Contributes to induction of acute itch, possibly through its activation on dorsal root ganglion neurons by the NMB peptide (PubMed:30734045). Plays a role in the innate immune response to influenza A virus infection by enhancing interferon alpha expression and reducing expression of IL6 (PubMed:31601264). Plays a role in CSF1-induced proliferation of osteoclast precursors by contributing to the positive regulation of the expression of the CSF1 receptor CSF1R (PubMed:28780306)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008188 neuropeptide receptor activity;GO:0004946 bombesin receptor activity;GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0032727 positive regulation of interferon-alpha production;GO:0007186 G protein-coupled receptor signaling pathway;GO:0032715 negative regulation of interleukin-6 production;GO:0090290 positive regulation of osteoclast proliferation;GO:0140374 antiviral innate immune response", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O54799-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62509-1", "uniprot_id": [ { "id": "ERR3_MOUSE", "url": "https://www.uniprot.org/uniprot/P62509", "type": "external" } ], "mass": 51306.0, "length": 458, "protein_name": "Estrogen-related receptor gamma", "gene_name": "Esrrg", "organism": "Mouse", "refseq_name": "estrogen-related receptor gamma isoform 2", "refseq_ac": [ { "id": "NP_001230721", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001230721", "type": "external" } ], "gene_names_uniprotkb": "Esrrg; Err3; Kiaa0832; Nr3b3", "gene_names_refseq": "ERR3; Errg; Esrrg; NR3B3; mKIAA0832", "protein_names_uniprotkb": "Estrogen-related receptor gamma; Estrogen receptor-related protein 3; Nuclear receptor subfamily 3 group B member 3", "protein_names_refseq": "estrogen receptor-related protein 3; estrogen-related receptor 3; estrogen-related receptor gamma isoform 2; nuclear receptor subfamily 3 group B member 3", "tax_id": 10090, "disease": "azoospermia (Disease Ontology:DOID:14227); cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:26381); (R-MMU-383280)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10428842;11864604;15161930;21750661;27335230;28572090;34428180;38733994;38912580", "class_list": "", "function": "ESRRG-controlled downregulation of KCNN1 in primary sensory neurons is required for neuropathic pain. Publication Status: Online-Only, [RefSeq, PubMed]; Metabolic regulator ERRgamma governs gastric stem cell differentiation into acid-secreting parietal cells., [RefSeq, PubMed]; Orphan receptor that acts as a transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements. Induces the expression of PERM1 in the skeletal muscle., [UniProtKB, PubMed]; Transcriptional activation by ERR3 can be ligand-independent., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 2, "mined_n_glycosites": 0, "mined_o_glycosites": 2, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O75454;O96021;Q8CHC9;Q9R1F3", "ec_number_list": [], "go_molecular_function": "GO:0034056 estrogen response element binding;GO:0003677 DNA binding;GO:0005516 calmodulin binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P62509-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0100010001001.011.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3KNJ2-1", "uniprot_id": [ { "id": "NHEJ1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3KNJ2", "type": "external" } ], "mass": 32739.0, "length": 295, "protein_name": "Non-homologous end-joining factor 1", "gene_name": "Nhej1", "organism": "Mouse", "refseq_name": "non-homologous end-joining factor 1 isoform 1", "refseq_ac": [ { "id": "NP_083618", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083618", "type": "external" } ], "gene_names_uniprotkb": "Nhej1; Xlf", "gene_names_refseq": "1700029B21Rik; Nhej1; XLF; cernunnos", "protein_names_uniprotkb": "Non-homologous end-joining factor 1; Protein cernunnos; XRCC4-like factor", "protein_names_refseq": "XRCC4-like factor; non-homologous end-joining factor 1 isoform 1; nonhomologous end-joining factor 1; protein cernunnos", "tax_id": 10090, "disease": "severe combined immunodeficiency 124 (Disease Ontology:DOID:0061090)", "pathway": " (mmu:75570); (R-MMU-5693571)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "17360556;18775323;21183079;21750661;27601299;27601633;27798842;27830975;28051062;29077092;30017584;31219806;37027298", "class_list": "", "function": "DNA repair protein involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair and V(D)J recombination (PubMed:17360556, PubMed:27601299, PubMed:27601633, PubMed:27798842, PubMed:27830975, PubMed:28051062, PubMed:29077092, PubMed:30017584). It is also involved in telomere maintenance (By similarity). Plays a key role in NHEJ by promoting the ligation of various mismatched and non-cohesive ends (PubMed:17360556). Interacts with POLL (DNA polymerase lambda); promoting POLL recruitment to double-strand breaks (DSBs) and stimulation of the end-filling activity of POLL (By similarity). May act in concert with XRCC5-XRCC6 (Ku) to stimulate XRCC4-mediated joining of blunt ends and several types of mismatched ends that are non-complementary or partially complementary (PubMed:17360556). In some studies, has been shown to associate with XRCC4 to form alternating helical filaments that bridge DNA and act like a bandage, holding together the broken DNA until it is repaired (By similarity). Alternatively, it has also been shown that rather than forming filaments, a single NHEJ1 dimer interacts through both head domains with XRCC4 to promote the close alignment of DNA ends (By similarity). The XRCC4-NHEJ1/XLF subcomplex binds to the DNA fragments of a DSB in a highly diffusive manner and robustly bridges two independent DNA molecules, holding the broken DNA fragments in close proximity to one other (By similarity). The mobility of the bridges ensures that the ends remain accessible for further processing by other repair factors (By similarity). Binds DNA in a length-dependent manner (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; XLF/Cernunnos loss impairs mouse brain development by altering symmetric proliferative divisions of neural progenitors., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2RT39;Q99JK0;Q9D9U0", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0070182 DNA polymerase binding;GO:0045027 DNA end binding", "go_cellular_component": "GO:0070419 nonhomologous end joining complex;GO:0032807 DNA ligase IV complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0001650 fibrillar center", "go_biological_process": "GO:0000723 telomere maintenance;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0010212 response to ionizing radiation;GO:0030183 B cell differentiation;GO:0030217 T cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q3KNJ2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q571B6-1", "uniprot_id": [ { "id": "WHAMM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q571B6", "type": "external" } ], "mass": 88997.0, "length": 793, "protein_name": "WASP homolog-associated protein with actin, membranes and microtubules", "gene_name": "Whamm", "organism": "Mouse", "refseq_name": "WASP homolog-associated protein with actin, membranes and microtubules", "refseq_ac": [ { "id": "NP_001004185", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004185", "type": "external" } ], "gene_names_uniprotkb": "Whamm; Kiaa1971; Whdc1", "gene_names_refseq": "Whamm; Whdc1; mKIAA1971", "protein_names_uniprotkb": "WASP homolog-associated protein with actin, membranes and microtubules; WAS protein homology region 2 domain-containing protein 1; WH2 domain-containing protein 1", "protein_names_refseq": "WAS protein homology region 2 domain containing 1; WAS protein homology region 2 domain-containing protein 1; WASP homolog-associated protein with actin, membranes and microtubules; WH2 domain-containing protein 1", "tax_id": 10090, "disease": "Fanconi syndrome (Disease Ontology:DOID:1062)", "pathway": " (mmu:434204)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "18614018;21183079;21750661;23160625;31219806;34428180;36210013;38598293", "class_list": "", "function": "Acts as a nucleation-promoting factor (NPF) that stimulates Arp2/3-mediated actin polymerization both at the Golgi apparatus and along tubular membranes. Involved as a regulator of Golgi positioning and morphology. Its activity in membrane tubulation requires F-actin and interaction with microtubules. Proposed to use coordinated actin-nucleating and microtubule-binding activities of distinct WHAMM molecules to drive membrane tubule elongation; when MT-bound can recruit and remodel membrane vesicles but is prevented to activate the Arp2/3 complex. Required for RhoD-dependent actin reorganization such as in cell adhesion and cell migration (By similarity). Participates in vesicle transport between the endoplasmic reticulum and the Golgi complex., [UniProtKB, PubMed, UniProtKB]; Data suggest that WHAMM is required for peripheral spindle migration and asymmetric cytokinesis during mouse oocyte maturation, [RefSeq, PubMed]; WHAMM functions in kidney reabsorption and polymerizes actin to promote autophagosomal membrane closure and cargo sequestration., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80VK9;Q80YT0;Q8BJP8", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0008017 microtubule binding;GO:0031267 small GTPase binding;GO:0071933 Arp2/3 complex binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0007015 actin filament organization;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0030032 lamellipodium assembly;GO:0048041 focal adhesion assembly;GO:0034314 Arp2/3 complex-mediated actin nucleation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q571B6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19324-1", "uniprot_id": [ { "id": "SERPH_MOUSE", "url": "https://www.uniprot.org/uniprot/P19324", "type": "external" } ], "mass": 46534.0, "length": 417, "protein_name": "Serpin H1", "gene_name": "Serpinh1", "organism": "Mouse", "refseq_name": "serpin H1 precursor", "refseq_ac": [ { "id": "NP_001104513", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104513", "type": "external" } ], "gene_names_uniprotkb": "Serpinh1; Cbp1; Hsp47", "gene_names_refseq": "BERF-1; Cbp1; Cbp2; Hsp47; J6; Serpinh1; Serpinh2; gp46", "protein_names_uniprotkb": "Serpin H1; 47 kDa heat shock protein; Collagen-binding protein; Colligin; Serine protease inhibitor J6", "protein_names_refseq": "47 kDa heat shock protein; beta enolase repressor factor 1; collagen binding protein 1; colligin; serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 1; serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 2; serine protease inhibitor J6; serpin H1 precursor; serpin H1", "tax_id": 10090, "disease": "osteogenesis imperfecta type 10 (Disease Ontology:DOID:0110346); preterm premature rupture of the membranes (Disease Ontology:DOID:0111144); liver cirrhosis (Disease Ontology:DOID:5082)", "pathway": " (mmu:12406); (R-MMU-1650814)", "pathway_count": 2, "publication_count": 24, "publication_id_list": "10.1101/2023.09.13.557529;12542794;1317794;1639782;21750661;22645316;23806337;2394749;25428506;26495903;30059200;30084848;30779550;30899004;31219806;31599954;34428180;35820727;36288343;37507081;37828378;37951979;39927985;8482533", "class_list": "", "function": "Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen., [UniProtKB]; HSP47 levels determine the degree of body adiposity. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 7, "disease_count": 3, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q5U4D0", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0051082 unfolded protein binding;GO:0005518 collagen binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0031012 extracellular matrix", "go_biological_process": "GO:0030199 collagen fibril organization;GO:0051604 protein maturation;GO:0032964 collagen biosynthetic process;GO:0003433 chondrocyte development involved in endochondral bone morphogenesis", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "P19324-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CG80-1", "uniprot_id": [ { "id": "SHF_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CG80", "type": "external" } ], "mass": 26893.0, "length": 238, "protein_name": "SH2 domain-containing adapter protein F", "gene_name": "Shf", "organism": "Mouse", "refseq_name": "SH2 domain-containing adapter protein F isoform 2", "refseq_ac": [ { "id": "NP_001013851", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013851", "type": "external" } ], "gene_names_uniprotkb": "Shf", "gene_names_refseq": "Shf", "protein_names_uniprotkb": "SH2 domain-containing adapter protein F", "protein_names_refseq": "SH2 domain-containing adapter protein F isoform 2; SH2 domain-containing adapter protein F", "tax_id": 10090, "disease": "", "pathway": " (mmu:435684)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "18034455;21183079;21750661;30006735", "class_list": "", "function": "Adapter protein which may play a role in the regulation of apoptosis in response to PDGF., [UniProtKB, UniProtKB]; These results, obtained from the integrative approach, suggest that LBH and SHF are associated with the Alzheimer's disease pathogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AQ90;A2AQ91", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0007165 signal transduction;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8CG80-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TXX3-1", "uniprot_id": [ { "id": "ZFY27_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TXX3", "type": "external" } ], "mass": 46202.0, "length": 415, "protein_name": "Protrudin", "gene_name": "Zfyve27", "organism": "Mouse", "refseq_name": "protrudin isoform 2", "refseq_ac": [ { "id": "NP_001158003", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158003", "type": "external" } ], "gene_names_uniprotkb": "Zfyve27", "gene_names_refseq": "2210011N02Rik; 9530077C24Rik; Zfyve27", "protein_names_uniprotkb": "Protrudin; Zinc finger FYVE domain-containing protein 27", "protein_names_refseq": "protrudin isoform 2; protrudin; zinc finger FYVE domain-containing protein 27", "tax_id": 10090, "disease": "", "pathway": " (mmu:319740)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "17082457;18459960;21750661;21976701;24251978;24668814;26495903;31772151;32917905;33172474;34428180;36210013", "class_list": "", "function": "Molecular tethering protein, which plays a role in the formation of membrane contact sites between the endoplasmic reticulum and late endosomes/lysosomes (PubMed:32917905). Promotes neurite formation by tethering endosomes to the endoplasmic reticulum membrane: interacts with Rab7-positive late endosomes, acting as a bridge to form endoplasmic reticulum membrane-endosome contact sites (PubMed:32917905). Acts in cooperation with vesicle-associated membrane protein-associated protein (VAPA or VAPB), thereby facilitating loading of the endosome membrane with KIF5, which is required for movement of the endosomes along microtubules in the plus-end direction (By similarity). Also associates with Rab11-positive recycling endosomes, facilitating exocytosis and membrane expansion (By similarity). Contributes to both the formation and stabilization of the tubular endoplasmic reticulum network (By similarity). Involved in endoplasmic reticulum morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections (By similarity)., [UniProtKB, UniProtKB, PubMed]; Protrudin and KIF5 interact in mouse brain.Protrudin-KIF5 complex contributes to the vesicular transport in neurons., [RefSeq, PubMed]; Protrudin and PDZD8 contribute to neuronal integrity by promoting lipid extraction required for endosome maturation. Publication Status: Online-Only, [RefSeq, PubMed]; Protrudin modulates seizure activity through GABAA receptor regulation. Publication Status: Online-Only, [RefSeq, PubMed]; Protrudin regulates Rab11-dependent membrane recycling to promote the directional membrane trafficking required for neurite formation [protrudin], [RefSeq, PubMed]; Protrudin-deficient mice manifest depression-like behavior with abnormalities in activity, attention, and cued fear-conditioning. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8CFP8", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0032584 growth cone membrane;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0031175 neuron projection development;GO:0072659 protein localization to plasma membrane;GO:0016192 vesicle-mediated transport;GO:0045773 positive regulation of axon extension;GO:0048011 neurotrophin TRK receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q3TXX3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q69ZI1-1", "uniprot_id": [ { "id": "SH3R1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q69ZI1", "type": "external" } ], "mass": 93447.0, "length": 892, "protein_name": "E3 ubiquitin-protein ligase SH3RF1", "gene_name": "Sh3rf1", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase SH3RF1", "refseq_ac": [ { "id": "NP_067481", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067481", "type": "external" } ], "gene_names_uniprotkb": "Sh3rf1; Kiaa1494; Posh1; Posh; Sh3md2", "gene_names_refseq": "2200003J05Rik; Posh; Sh3md2; Sh3rf1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase SH3RF1; 2.3.2.27; Plenty of SH3s; Protein POSH; RING-type E3 ubiquitin transferase SH3RF1; SH3 domain-containing RING finger protein 1; SH3 multiple domains protein 2", "protein_names_refseq": "E3 ubiquitin-protein ligase SH3RF1; RING-type E3 ubiquitin transferase SH3RF1; SH3 domain-containing RING finger protein 1; SH3 multiple domains 2; SH3 multiple domains protein 2; plenty of SH3 domains; plenty of SH3s; putative E3 ubiquitin-protein ligase SH3RF1", "tax_id": 10090, "disease": "retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (mmu:59009); (R-MMU-9013424); (R-MMU-983168)", "pathway_count": 3, "publication_count": 24, "publication_id_list": "10.1101/2023.09.13.557529;12514131;14504284;16230351;16571722;21183079;21750661;22517741;22645316;22959435;23963642;27084103;29237092;29432529;30016717;31219806;32782141;32848054;35385725;35822049;36852467;40021952;40885482;9482736", "class_list": "", "function": "Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination. Stimulates ubiquitination of potassium channel KCNJ1, enhancing its dynamin-dependent and clathrin-independent endocytosis (By similarity). Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the differentiation of CD4(+) and CD8(+) T-cells and promotes T-helper 1 (Th1) cell differentiation. Regulates the activation of MAPK8/JNK1 and MAPK9/JNK2 in CD4(+) T-cells and the activation of MAPK8/JNK1 in CD8(+) T-cells (PubMed:23963642, PubMed:27084103, PubMed:9482736). Plays a crucial role in the migration of neocortical neurons in the developing brain. Controls proper cortical neuronal migration and the formation of proximal cytoplasmic dilation in the leading process (PCDLP) in migratory neocortical neurons by regulating the proper localization of activated RAC1 and F-actin assembly (PubMed:22959435)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; POSH regulates assembly of the NMDAR/PSD-95/Shank complex and synaptic function., [RefSeq, PubMed]; Siah1 is a binding partner for POSH (plenty of SH3s), a scaffold component of the apoptotic JNK pathway, [RefSeq, PubMed]; The pro-apoptotic JNK scaffold protein POSH mediates CHMP2BIntron5-associated toxicity in animal models of frontotemporal dementia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 8, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 8, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 8, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "O70254;Q3UG42;Q6P9M8;Q8BR66;Q8C2T5", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0005078 MAP-kinase scaffold activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0030027 lamellipodium;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:2000564 regulation of CD8-positive, alpha-beta T cell proliferation;GO:0043066 negative regulation of apoptotic process;GO:0046330 positive regulation of JNK cascade;GO:0001764 neuron migration;GO:2001237 negative regulation of extrinsic apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "Q69ZI1-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99MJ6-1", "uniprot_id": [ { "id": "NHRF4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99MJ6", "type": "external" } ], "mass": 53525.0, "length": 498, "protein_name": "Na(+)/H(+) exchange regulatory cofactor NHE-RF4", "gene_name": "Nherf4", "organism": "Mouse", "refseq_name": "Na(+)/H(+) exchange regulatory cofactor NHE-RF4", "refseq_ac": [ { "id": "NP_573489", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_573489", "type": "external" } ], "gene_names_uniprotkb": "Nherf4; Pdzd3; Pdzk2", "gene_names_refseq": "NaPi-Cap2; Nherf4; Pdzd3; Pdzk2", "protein_names_uniprotkb": "Na(+)/H(+) exchange regulatory cofactor NHE-RF4; NHERF-4; Na/Pi cotransporter C-terminal-associated protein 2; NaPi-Cap2; Natrium-phosphate cotransporter IIa C-terminal-associated protein 2; PDZ domain-containing protein 2; PDZ domain-containing protein 3; Sodium-hydrogen exchanger regulatory factor 4", "protein_names_refseq": "NHERF-4; Na(+)/H(+) exchange regulatory cofactor NHE-RF4; PDZ domain containing 2; PDZ domain containing 3; PDZ domain-containing protein 2; PDZ domain-containing protein 3; na/Pi cotransporter C-terminal-associated protein 2; natrium-phosphate cotransporter IIa C-terminal-associated protein 2; sodium-hydrogen exchanger regulatory factor 4; sodium-phosphate cotransporter IIa C-terminal-associated protein 2", "tax_id": 10090, "disease": "hypophosphatemic nephrolithiasis/osteoporosis 2 (Disease Ontology:DOID:0080078)", "pathway": " (mmu:170761)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11099500;17645868;19088451;21750661;22627094;25428506;26756164", "class_list": "", "function": "Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation (By similarity). Stimulates SLC9A3 activity in the presence of elevated calcium ions (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; PDZK2 is an essential TRPV6 interacting protein as a physiological modulator of TRPV6., [RefSeq, PubMed]; Regulation of NHE3 depends on the nature of the NHERF family member associating with NHE3 and the accompanying NHE3 complexes.[IKEPP], [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BWE5", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0043495 protein-membrane adaptor activity;GO:1990381 ubiquitin-specific protease binding;GO:0030251 guanylate cyclase inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005903 brush border;GO:0016020 membrane;GO:0045177 apical part of cell", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0010754 negative regulation of cGMP-mediated signaling", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q99MJ6-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0Y9-1", "uniprot_id": [ { "id": "NR1H3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z0Y9", "type": "external" } ], "mass": 50418.0, "length": 445, "protein_name": "Oxysterols receptor LXR-alpha", "gene_name": "Nr1h3", "organism": "Mouse", "refseq_name": "oxysterols receptor LXR-alpha", "refseq_ac": [ { "id": "NP_001171201", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171201", "type": "external" } ], "gene_names_uniprotkb": "Nr1h3; Lxra", "gene_names_refseq": "LXR; Nr1h3; RLD1; Unr1", "protein_names_uniprotkb": "Oxysterols receptor LXR-alpha; Liver X receptor alpha; Nuclear receptor subfamily 1 group H member 3", "protein_names_refseq": "LXR alpha; liver X receptor alpha; oxysterols receptor LXR-alpha; ubiquitously-expressed nuclear receptor 1", "tax_id": 10090, "disease": "metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); pre-eclampsia (Disease Ontology:DOID:10591); carotid stenosis (Disease Ontology:DOID:13001); atherosclerosis (Disease Ontology:DOID:1936); coronary artery disease (Disease Ontology:DOID:3393); cerebral infarction (Disease Ontology:DOID:3526); ovarian hyperstimulation syndrome (Disease Ontology:DOID:5425); myocardial infarction (Disease Ontology:DOID:5844); cerebrovascular disease (Disease Ontology:DOID:6713); abdominal aortic aneurysm (Disease Ontology:DOID:7693); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:22259); (R-MMU-383280); (R-MMU-4090294); (R-MMU-8866427); (R-MMU-9029569); (R-MMU-9623433)", "pathway_count": 6, "publication_count": 19, "publication_id_list": "10675617;10890879;16107141;18055760;18800767;19167885;19520913;20427281;21750661;24206663;25724563;25806685;27383786;28661453;28846071;29950315;32496563;33772096;34428180", "class_list": "", "function": "Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:18055760, PubMed:19520913, PubMed:20427281). Interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis (PubMed:25806685, PubMed:28846071). Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles (PubMed:25806685). Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators (PubMed:24206663)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9QUH7", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0044877 protein-containing complex binding;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0048550 negative regulation of pinocytosis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006629 lipid metabolic process;GO:0010875 positive regulation of cholesterol efflux;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q9Z0Y9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQ80-1", "uniprot_id": [ { "id": "NIF3L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EQ80", "type": "external" } ], "mass": 41746.0, "length": 376, "protein_name": "NIF3-like protein 1", "gene_name": "Nif3l1", "organism": "Mouse", "refseq_name": "NIF3-like protein 1", "refseq_ac": [ { "id": "NP_075364", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075364", "type": "external" } ], "gene_names_uniprotkb": "Nif3l1", "gene_names_refseq": "1110030G24Rik; Nif3l1", "protein_names_uniprotkb": "NIF3-like protein 1", "protein_names_refseq": "GTP cyclohydrolase I; NIF3-like protein 1; Ngg1 interacting factor 3 homolog-like 1; putative GTP cyclohydrolase 1 type 2 Nif3l1", "tax_id": 10090, "disease": "", "pathway": " (mmu:65102)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11124544;12522100;12951069;21183079;21750661;34428180;35820727;37507081", "class_list": "", "function": "May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Nif3l1 participates in neural differentiation of P19 cells through cooperation with Trip15/CSN2., [RefSeq, PubMed]; This gene is a member of the NGG1-interacting factor 3-like superfamily of transcriptional regulators and is ubiquitously expressed throughout embryonic development. The encoded protein interacts with a component of the constitutive photomorphogenesis 9 signalosome, and functions as a transcriptional corepressor of genes involved in neuronal differentiation. This gene is highly conserved from bacteria to human. [provided by RefSeq, Sep 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P1B7;Q9D098", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0030182 neuron differentiation;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9EQ80-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JL19-1", "uniprot_id": [ { "id": "NCOA6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JL19", "type": "external" } ], "mass": 219663.0, "length": 2067, "protein_name": "Nuclear receptor coactivator 6", "gene_name": "Ncoa6", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ncoa6; Aib3; Prip; Rap250; Trbp", "gene_names_refseq": "", "protein_names_uniprotkb": "Nuclear receptor coactivator 6; ASC-2; Activating signal cointegrator 2; Amplified in breast cancer protein 3; Cancer-amplified transcriptional coactivator ASC-2; NRC; Nuclear receptor coactivator RAP250; Nuclear receptor-activating protein, 250 kDa; PPAR-interacting protein; Peroxisome proliferator-activated receptor-interacting protein; Thyroid hormone receptor-binding protein", "protein_names_refseq": "", "tax_id": 10090, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930); lung cancer (Disease Ontology:DOID:1324); breast cancer (Disease Ontology:DOID:1612); colon cancer (Disease Ontology:DOID:219); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (R-MMU-400206); (R-MMU-9707564); (R-MMU-9772755); (R-MMU-9818564)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "10681503;10788465;11704680;21183079;21750661;22517741;23806337;24129315;26192747;31219806;34428180;35822049;36852467;40885482", "class_list": "", "function": "Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins. Involved in placental, cardiac, hepatic and embryonic development., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 8, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 8, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 8, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "Q9JLT9", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0019899 enzyme binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005667 transcription regulator complex;GO:0035097 histone methyltransferase complex", "go_biological_process": "GO:0007507 heart development;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0002793 positive regulation of peptide secretion;GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q9JL19-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70172-1", "uniprot_id": [ { "id": "NTCP2_MOUSE", "url": "https://www.uniprot.org/uniprot/P70172", "type": "external" } ], "mass": 38134.0, "length": 348, "protein_name": "Ileal sodium/bile acid cotransporter", "gene_name": "Slc10a2", "organism": "Mouse", "refseq_name": "ileal sodium/bile acid cotransporter", "refseq_ac": [ { "id": "NP_035518", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035518", "type": "external" } ], "gene_names_uniprotkb": "Slc10a2; Ntcp2", "gene_names_refseq": "9130221J18Rik; ASBT; IBAT; ISBT; Slc10a2", "protein_names_uniprotkb": "Ileal sodium/bile acid cotransporter; ASBT; Apical sodium-dependent bile acid transporter; IBAT; ISBT; Ileal Na(+)/bile acid cotransporter; Ileal sodium-dependent bile acid transporter; Na(+)-dependent ileal bile acid transporter; Sodium/taurocholate cotransporting polypeptide, ileal; Solute carrier family 10 member 2", "protein_names_refseq": "Na(+)-dependent ileal bile acid transporter; apical sodium-dependent bile acid transporter; ileal Na(+)/bile acid cotransporter; ileal sodium-dependent bile acid transporter; ileal sodium/bile acid cotransporter; sodium/taurocholate cotransporting polypeptide, ileal", "tax_id": 10090, "disease": "intestinal disease (Disease Ontology:DOID:5295)", "pathway": " (mmu:20494); (R-MMU-159418)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10101301;12819193;21183079;36410025", "class_list": "", "function": "Loss of apical sodium bile acid transporter alters bile acid circulation and reduces biliary damage in cholangitis., [RefSeq, PubMed]; Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine (PubMed:10101301). Transports various bile acids, unconjugated or conjugated, such as cholate and taurocholate (PubMed:10101301). Also responsible for bile acid transport in the renal proximal tubules, a salvage mechanism that helps conserve bile acids. Works collaboratively with the Na(+)-taurocholate cotransporting polypeptide (NTCP), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation (By similarity)., [UniProtKB, UniProtKB, PubMed]; Slc10a2 is essential for efficient intestinal absorption of bile acids, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8VI83;Q925U7", "ec_number_list": [], "go_molecular_function": "GO:0008508 bile acid:sodium symporter activity", "go_cellular_component": "GO:0016324 apical plasma membrane;GO:0005902 microvillus;GO:0000502 proteasome complex", "go_biological_process": "GO:0015721 bile acid and bile salt transport;GO:0009617 response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P70172-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35488-1", "uniprot_id": [ { "id": "S27A2_MOUSE", "url": "https://www.uniprot.org/uniprot/O35488", "type": "external" } ], "mass": 70423.0, "length": 620, "protein_name": "Long-chain fatty acid transport protein 2", "gene_name": "Slc27a2", "organism": "Mouse", "refseq_name": "long-chain fatty acid transport protein 2", "refseq_ac": [ { "id": "NP_036108", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036108", "type": "external" } ], "gene_names_uniprotkb": "Slc27a2; Acsvl1; Facvl1; Fatp2; Vlacs; Vlcs", "gene_names_refseq": "ACSVL1; FATP2; Slc27a2; VLCS; Vlacs; Vlac", "protein_names_uniprotkb": "Long-chain fatty acid transport protein 2; 6.2.1.-; 6.2.1.15; 6.2.1.24; 6.2.1.3; 6.2.1.7; Arachidonate--CoA ligase; FATP-2; Fatty acid transport protein 2; Fatty-acid-coenzyme A ligase, very long-chain 1; Long-chain-fatty-acid--CoA ligase; Phytanate--CoA ligase; Slc27a2; Solute carrier family 27 member 2; THCA-CoA ligase; VLACS; VLCS; Very long-chain acyl-CoA synthetase; Very long-chain-fatty-acid-CoA ligase", "protein_names_refseq": "FATP-2; THCA-CoA ligase; arachidonate--CoA ligase; fatty acid transport protein 2; fatty-acid-coenzyme A ligase, very long-chain 1; long-chain fatty acid transport protein 2; long-chain-fatty-acid--CoA ligase; phytanate--CoA ligase; solute carrier family 27 member 2; very long-chain acyl-CoA synthetase; very long-chain acyl-Coenzyme A dehydrogenase synthase; very long-chain-fatty-acid-CoA ligase", "tax_id": 10090, "disease": "", "pathway": " (mmu:26458); (R-MMU-193368); (R-MMU-193775); (R-MMU-389599); (R-MMU-390247); (R-MMU-6798695); (R-MMU-75105); (R-MMU-9033241)", "pathway_count": 8, "publication_count": 14, "publication_id_list": "11980911;15699031;20530735;21183079;21750661;23576753;30084848;34428180;36169895;37453647;38461272;38743615;9559670;9671728", "class_list": "", "function": "Bladder-cancer-derived exosomal circRNA_0013936 promotes suppressive immunity by up-regulating fatty acid transporter protein 2 and down-regulating receptor-interacting protein kinase 3 in PMN-MDSCs. Publication Status: Online-Only, [RefSeq, PubMed]; Epoxygenase Cyp2c44 Regulates Hepatic Lipid Metabolism and Insulin Signaling by Controlling FATP2 Localization and Activation of the DAG/PKCdelta Axis., [RefSeq, PubMed]; Feedback loop between fatty acid transport protein 2 and receptor interacting protein 3 pathways promotes polymorphonuclear neutrophil myeloid-derived suppressor cells-potentiated suppressive immunity in bladder cancer., [RefSeq, PubMed]; Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport across cell membranes, playing an important role in hepatic fatty acid uptake (PubMed:15699031, PubMed:20530735, PubMed:9671728). Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake (PubMed:15699031, PubMed:20530735). Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis (PubMed:15699031, PubMed:20530735). Can also activate branched-chain fatty acids such as phytanic acid and pristanic acid (By similarity). May contribute to the synthesis of sphingosine-1-phosphate (By similarity). Does not activate C24 bile acids, cholate and chenodeoxycholate (By similarity). In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. However, it is not critical for THCA activation and bile synthesis in vivo (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O70550;O88560;Q91WV6", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "1.14.19.17", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.17", "type": "external" }, { "id": "5.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.-", "type": "external" }, { "id": "5.1.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4", "type": "external" }, { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.4.21.73", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.73", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "2.3.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.78", "type": "external" }, { "id": "6.2.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.76", "type": "external" }, { "id": "1.6.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.-", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "1.5.3.13", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.13", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "6.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.2", "type": "external" }, { "id": "6.2.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.25", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "1.4.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1", "type": "external" }, { "id": "4.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.9", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "1.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.1", "type": "external" }, { "id": "1.5.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.7", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "1.2.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "2.3.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.20", "type": "external" }, { "id": "2.3.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.76", "type": "external" } ], "go_molecular_function": "GO:0015245 fatty acid transmembrane transporter activity;GO:0005324 long-chain fatty acid transmembrane transporter activity;GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0004467 long-chain fatty acid-CoA ligase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0000038 very long-chain fatty acid metabolic process;GO:0001676 long-chain fatty acid metabolic process;GO:0006635 fatty acid beta-oxidation;GO:0006699 bile acid biosynthetic process;GO:0042760 very long-chain fatty acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "O35488-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91X43-1", "uniprot_id": [ { "id": "SH319_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91X43", "type": "external" } ], "mass": 86077.0, "length": 789, "protein_name": "SH3 domain-containing protein 19", "gene_name": "Sh3d19", "organism": "Mouse", "refseq_name": "SH3 domain-containing protein 19 isoform 1", "refseq_ac": [ { "id": "NP_001075883", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075883", "type": "external" } ], "gene_names_uniprotkb": "Sh3d19", "gene_names_refseq": "Kryn; Sh3d19", "protein_names_uniprotkb": "SH3 domain-containing protein 19; Kryn", "protein_names_refseq": "SH3 domain containing protein D 19; SH3 domain-containing protein 19 isoform 1; SH3 domain-containing protein 19", "tax_id": 10090, "disease": "", "pathway": " (mmu:27059); (R-MMU-432722)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "12615363;17242355;21183079;21750661;34428180;35820727;39927985;40885482", "class_list": "", "function": "May play a role in regulating A disintegrin and metalloproteases (ADAMs) in the signaling of EGFR-ligand shedding. May be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1. Plays a role in the regulation of cell morphology and cytoskeletal organization., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Sh3d19 transcripts in mouse skin expressed in accordance with hair cycle. Transcripts detected predominantly in medulla cells at level corresponding to keratogenous zone of hair follicles during mid and late anagen phases., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O08635;O35146;Q8C7I2", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0070064 proline-rich region binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005737 cytoplasm", "go_biological_process": "GO:0051044 positive regulation of membrane protein ectodomain proteolysis;GO:0007010 cytoskeleton organization;GO:0022604 regulation of cell morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q91X43-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ES52-1", "uniprot_id": [ { "id": "SHIP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ES52", "type": "external" } ], "mass": 133542.0, "length": 1191, "protein_name": "Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1", "gene_name": "Inpp5d", "organism": "Mouse", "refseq_name": "phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform 2", "refseq_ac": [ { "id": "NP_001103662", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103662", "type": "external" } ], "gene_names_uniprotkb": "Inpp5d; 7a33; Ship1; Ship", "gene_names_refseq": "Inpp5d; SHIP-1; SHIP1; SHIP; SIP-145; p150Ship; s-SHIP", "protein_names_uniprotkb": "Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1; 3.1.3.36; 3.1.3.56; 3.1.3.86; Inositol polyphosphate-5-phosphatase D; Inositol polyphosphate-5-phosphatase of 145 kDa; Phosphatidylinositol-4,5-bisphosphate 5-phosphatase; SH2 domain-containing inositol 5'-phosphatase 1; SH2 domain-containing inositol phosphatase 1; SHIP-1; SIP-145; p150Ship", "protein_names_refseq": "SH2 domain-containing inositol 5'-phosphatase 1; SH2 domain-containing inositol phosphatase 1; SH2-containing inositol phosphatase SHIP; Src homology 2 domain-containing inositol-5-phosphatase; inositol polyphosphate-5-phosphatase, 145 kDa; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform 2; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1; phosphatidylinositol-4,5-bisphosphate 5-phosphatase", "tax_id": 10090, "disease": "Paget's disease of bone (Disease Ontology:DOID:5408); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:16331); (R-MMU-1660499); (R-MMU-1855204); (R-MMU-202424); (R-MMU-210990); (R-MMU-912526)", "pathway_count": 6, "publication_count": 64, "publication_id_list": "10.1101/2023.09.13.557529;10068665;10395202;10660611;10779347;10794720;11013080;11016922;11031258;11136821;11222379;11247302;11359765;11567986;11896575;12161749;12370370;12393695;12447389;12882960;14993273;15166241;15456754;15492005;16000869;16406061;17105399;17142780;17173042;17947660;19144319;20526344;21183079;21750661;25605945;30084848;31599954;32823063;34428180;38777089;38923164;38923171;39627609;8632995;8643691;8654924;8723348;8805618;8805703;9027494;9083021;9099679;9110989;9244303;9341117;9367159;9393882;9485206;9531585;9620849;9694708;9736736;9763612;9857188", "class_list": "", "function": "Inpp5d haplodeficiency alleviates tau pathology in the PS19 mouse model of Tauopathy., [RefSeq, PubMed]; Loss of Inpp5d has disease-relevant and sex-specific effects on glial transcriptomes., [RefSeq, PubMed]; Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (By similarity). Also, is able to hydrolyze the 5-phosphate of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P3), 1D-myo-inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate (PubMed:9367159). Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; SHIP1 modulation and proteome characterization of microglia., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3UPF9;Q4U212;Q61034;Q61173;Q61181;Q9JKR7;Q9JLF9;Q9JLG0;Q9QVN8;Q9WUC2", "ec_number_list": [ { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.95", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.95", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "2.7.1.134", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.134", "type": "external" }, { "id": "2.7.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.159", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" } ], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0051425 PTB domain binding;GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity;GO:0004445 inositol-polyphosphate 5-phosphatase activity;GO:0052659 inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005884 actin filament;GO:0005886 plasma membrane;GO:0045121 membrane raft", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0035556 intracellular signal transduction;GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0032715 negative regulation of interleukin-6 production", "synthesized_glycan_count": 0, "hit_score": 6.9, "record_id": "Q9ES52-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QXS6-1", "uniprot_id": [ { "id": "DREB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QXS6", "type": "external" } ], "mass": 77287.0, "length": 706, "protein_name": "Drebrin", "gene_name": "Dbn1", "organism": "Mouse", "refseq_name": "drebrin isoform 1", "refseq_ac": [ { "id": "NP_001170842", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001170842", "type": "external" } ], "gene_names_uniprotkb": "Dbn1; Drba", "gene_names_refseq": "Dbn1", "protein_names_uniprotkb": "Drebrin; Developmentally-regulated brain protein", "protein_names_refseq": "developmentally-regulated brain protein; drebrin A; drebrin E2; drebrin isoform 1", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); sciatic neuropathy (Disease Ontology:DOID:11446); Down syndrome (Disease Ontology:DOID:14250); Parkinson's disease (Disease Ontology:DOID:14330); cognitive disorder (Disease Ontology:DOID:1561); transient cerebral ischemia (Disease Ontology:DOID:224); temporal lobe epilepsy (Disease Ontology:DOID:3328)", "pathway": " (mmu:56320)", "pathway_count": 1, "publication_count": 24, "publication_id_list": "10633083;11991718;12761245;15345747;16452087;21183079;21750661;22645316;24637538;24720729;24788674;25153642;25865831;25945928;26495903;28135057;30084848;32848054;33300544;34428180;34678516;34887587;38271699;38376048", "class_list": "", "function": "A lack of drebrin causes olfactory impairment., [RefSeq, PubMed]; Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections (By similarity). Required for actin polymerization at immunological synapses (IS) and for the recruitment of the chemokine receptor CXCR4 to IS (By similarity). Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines (PubMed:25865831). Involved in memory-related synaptic plasticity in the hippocampus (PubMed:25865831)., [UniProtKB, UniProtKB, PubMed]; Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections. Required for actin polymerization at immunological synapses (IS) and for the recruitment of the chemokine receptor CXCR4 to IS. Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines. Involved in memory-related synaptic plasticity in the hippocampus., [UniProtKB, UniProtKB]; Drebrin is Required for Myosin-facilitated Actin Cytoskeletal Remodeling during Pulmonary Alveolar Development., [RefSeq, PubMed]; Drebrin is involved in regulation of actin dynamics also outside the nervous system. Drebrin is one of the actin-binding proteins regulating the actomyosin system and the dynamics of mesangial cells and foot processes in podocytes., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A2CG16;Q3V234;Q922X1;Q9QXS5", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0008092 cytoskeletal protein binding;GO:0005522 profilin binding;GO:0140311 protein sequestering activity;GO:0140661 cytoskeletal motor inhibitor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098871 postsynaptic actin cytoskeleton;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005884 actin filament", "go_biological_process": "GO:0032507 maintenance of protein location in cell;GO:0098828 modulation of inhibitory postsynaptic potential;GO:1904113 negative regulation of muscle filament sliding;GO:0001701 in utero embryonic development;GO:0007015 actin filament organization", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q9QXS6-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35438-1", "uniprot_id": [ { "id": "NMDZ1_MOUSE", "url": "https://www.uniprot.org/uniprot/P35438", "type": "external" } ], "mass": 105481.0, "length": 938, "protein_name": "Glutamate receptor ionotropic, NMDA 1", "gene_name": "Grin1", "organism": "Mouse", "refseq_name": "glutamate receptor ionotropic, NMDA 1 isoform 2", "refseq_ac": [ { "id": "NP_001171127", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171127", "type": "external" } ], "gene_names_uniprotkb": "Grin1; Glurz1", "gene_names_refseq": "GluN1; GluRdelta1; GluRzeta1; Grin1; M100174; NMD-R1; NMDAR1; NR1; Nmdar; Rgsc174", "protein_names_uniprotkb": "Glutamate receptor ionotropic, NMDA 1; GluN1; Glutamate [NMDA] receptor subunit zeta-1; N-methyl-D-aspartate receptor subunit NR1; NMD-R1", "protein_names_refseq": "N-methyl-D-aspartate receptor subunit NR1; glutamate [NMDA] receptor subunit zeta-1; glutamate receptor ionotropic, NMDA 1 isoform 2; glutamate receptor ionotropic, NMDA 1", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal dominant neurodevelopmental disorder with or without hyperkinetic movements and seizures (Disease Ontology:DOID:0070038); developmental and epileptic encephalopathy 101 (Disease Ontology:DOID:0070387); Alzheimer's disease (Disease Ontology:DOID:10652); opioid abuse (Disease Ontology:DOID:11206); sciatic neuropathy (Disease Ontology:DOID:11446); neurodegenerative disease (Disease Ontology:DOID:1289); cognitive disorder (Disease Ontology:DOID:1561); alcohol use disorder (Disease Ontology:DOID:1574); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); middle cerebral artery infarction (Disease Ontology:DOID:3525); cerebral infarction (Disease Ontology:DOID:3526); placental insufficiency (Disease Ontology:DOID:3891); schizophrenia (Disease Ontology:DOID:5419); vascular dementia (Disease Ontology:DOID:8725)", "pathway": " (mmu:14810); (R-MMU-3928662); (R-MMU-438066); (R-MMU-5673001); (R-MMU-8849932); (R-MMU-9609736)", "pathway_count": 6, "publication_count": 35, "publication_id_list": "10.1101/2023.09.13.557529;12008020;12860921;14602821;14662521;1532151;17329422;18000809;18849881;18940194;19283475;19751394;19776282;21277878;21750661;22383997;23524343;25080220;25120077;25301084;25557043;26041915;26390873;26490687;30899004;31599954;33300544;35180934;36058615;37142655;40885482;7790891;8060614;9030583;9049108", "class_list": "", "function": "Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:12008020, PubMed:12860921, PubMed:14602821, PubMed:1532151, PubMed:8060614, PubMed:9049108). NMDARs participate in synaptic plasticity for learning and memory formation by contributing to the long-term potentiation (LTP) (By similarity). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:12008020, PubMed:1532151, PubMed:7790891, PubMed:8060614). NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium (PubMed:12860921). Each GluN2 or GluN3 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (PubMed:12008020, PubMed:14602821)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 12, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 11, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 12, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 12, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 21, "disease_count": 16, "glyco_site_count": 17, "binding_glycan_count": 0, "secondary_ac_list": "A2AI15;A2AI18;Q8CFS4", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0022849 glutamate-gated calcium ion channel activity;GO:0022824 transmitter-gated monoatomic ion channel activity;GO:0005102 signaling receptor binding;GO:0005262 calcium channel activity;GO:0005516 calmodulin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0017146 NMDA selective glutamate receptor complex;GO:0048787 presynaptic active zone membrane;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0060179 male mating behavior;GO:0001964 startle response;GO:1903539 protein localization to postsynaptic membrane;GO:0001967 suckling behavior", "synthesized_glycan_count": 0, "hit_score": 7.3, "record_id": "P35438-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02780-1", "uniprot_id": [ { "id": "NFIA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q02780", "type": "external" } ], "mass": 58553.0, "length": 532, "protein_name": "Nuclear factor 1 A-type", "gene_name": "Nfia", "organism": "Mouse", "refseq_name": "nuclear factor 1 A-type isoform 1", "refseq_ac": [ { "id": "NP_001116424", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116424", "type": "external" } ], "gene_names_uniprotkb": "Nfia", "gene_names_refseq": "1110047K16Rik; 9430022M17Rik; CTF; NF1-A; NF1A; Nfia", "protein_names_uniprotkb": "Nuclear factor 1 A-type; CCAAT-box-binding transcription factor; CTF; NF-I/A; NF1-A; NFI-A; Nuclear factor 1/A; Nuclear factor I/A; TGGCA-binding protein", "protein_names_refseq": "CCAAT-box-binding transcription factor; TGGCA-binding protein; nuclear factor 1 A-type isoform 1; nuclear factor 1 A-type; nuclear factor 1/A", "tax_id": 10090, "disease": "NFIA-related disorder (Disease Ontology:DOID:0060409)", "pathway": " (mmu:18027)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10087299;11978849;12568726;15345747;1699939;17242355;21183079;21750661;22517741;23443134;24129315;34678516;40997131;9056636", "class_list": "", "function": "Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 8, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 8, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 8, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "P70250;P70251;Q3UUZ2;Q61960;Q8VBT5;Q9R1G5", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0030054 cell junction", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0000902 cell morphogenesis;GO:0006260 DNA replication", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q02780-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4ACU6-1", "uniprot_id": [ { "id": "SHAN3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q4ACU6", "type": "external" } ], "mass": 185397.0, "length": 1730, "protein_name": "SH3 and multiple ankyrin repeat domains protein 3", "gene_name": "Shank3", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Shank3; Kiaa1650; Prosap2", "gene_names_refseq": "", "protein_names_uniprotkb": "SH3 and multiple ankyrin repeat domains protein 3; ProSAP2; Proline-rich synapse-associated protein 2; SPANK-2; Shank3", "protein_names_refseq": "", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); schizophrenia 15 (Disease Ontology:DOID:0070091); Phelan-McDermid syndrome (Disease Ontology:DOID:0080354); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:58234); (R-MMU-6794361); (R-MMU-8853659)", "pathway_count": 3, "publication_count": 20, "publication_id_list": "16452087;16606358;17242355;18034455;20613842;21183079;21423165;21558424;21750661;22645316;22699619;23739967;24129315;24153177;24164323;24259569;30610205;31600191;33300544;38233523", "class_list": "", "function": "Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 32, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "F8S0X0;F8S0X2;F8S0X3;F8S0X5;F8S0X6;Q69ZD8;Q9JJZ3;S6BMD3;S6CCV8", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0008270 zinc ion binding;GO:0017124 SH3 domain binding;GO:0042802 identical protein binding;GO:0001664 G protein-coupled receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0043197 dendritic spine", "go_biological_process": "GO:0097107 postsynaptic density assembly;GO:1900452 regulation of long-term synaptic depression;GO:0097117 guanylate kinase-associated protein clustering;GO:1904717 regulation of AMPA glutamate receptor clustering;GO:0050975 sensory perception of touch", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q4ACU6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08609-1", "uniprot_id": [ { "id": "MLX_MOUSE", "url": "https://www.uniprot.org/uniprot/O08609", "type": "external" } ], "mass": 33339.0, "length": 298, "protein_name": "Max-like protein X", "gene_name": "Mlx", "organism": "Mouse", "refseq_name": "max-like protein X isoform alpha", "refseq_ac": [ { "id": "NP_001152856", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152856", "type": "external" } ], "gene_names_uniprotkb": "Mlx; Tcfl4", "gene_names_refseq": "Mlx; Tcfl4; Tf4; bHLHd13", "protein_names_uniprotkb": "Max-like protein X; Max-like bHLHZip protein; Protein BigMax; Transcription factor-like protein 4", "protein_names_refseq": "BigMax alpha; MAX-like bHLHZIP protein; max-like protein X isoform alpha; protein BigMax; transcription factor-like 4; transcription factor-like protein 4", "tax_id": 10090, "disease": "oligoasthenoteratozoospermia (Disease Ontology:DOID:0070311); Takayasu's arteritis (Disease Ontology:DOID:2508)", "pathway": " (mmu:21428)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10593926;10918583;11073985;16644671;17242355;20484733;21183079;21750661;31219806;34669700;8973301", "class_list": "", "function": "The glucose-sensing transcription factor MLX balances metabolism and stress to suppress apoptosis and maintain spermatogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MAD1, MAD4, MNT, WBSCR14 and MLXIP which recognizes the core sequence 5'-CACGTG-3'. The TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14 complexes are transcriptional repressors. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9EQJ7;Q9EQJ8", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031965 nuclear membrane", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006913 nucleocytoplasmic transport;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O08609-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99KK2-1", "uniprot_id": [ { "id": "NEUA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99KK2", "type": "external" } ], "mass": 48058.0, "length": 432, "protein_name": "N-acylneuraminate cytidylyltransferase", "gene_name": "Cmas", "organism": "Mouse", "refseq_name": "N-acylneuraminate cytidylyltransferase isoform 1", "refseq_ac": [ { "id": "NP_034038", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034038", "type": "external" } ], "gene_names_uniprotkb": "Cmas", "gene_names_refseq": "CMPNeu5Ac; Cmas; D6Bwg0250e", "protein_names_uniprotkb": "N-acylneuraminate cytidylyltransferase; 2.7.7.43; CMP-N-acetylneuraminic acid synthase; CMP-NeuNAc synthase", "protein_names_refseq": "CMP-N-acetylneuraminic acid synthase; CMP-N-acetylneuraminic acid synthetase; CMP-Neu5Ac synthase; CMP-NeuNAc synthase; CMP-NeuNAc synthetase; CMP-sialic acid synthetase; N-acylneuraminate cytidylyltransferase isoform 1; N-acylneuraminate cytidylyltransferase", "tax_id": 10090, "disease": "focal segmental glomerulosclerosis (Disease Ontology:DOID:1312)", "pathway": " (mmu:12764); (R-MMU-4085001)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "11893746;14636592;21750661;22645316;24129315;27802388;33087464;9689047", "class_list": "glycogene", "function": "Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Cytidine Monophosphate N-Acetylneuraminic Acid Synthetase and Solute Carrier Family 35 Member A1 Are Required for Reovirus Binding and Infection. Publication Status: Online-Only, [RefSeq, PubMed]; Nuclear localization signal of murine CMP-Neu5Ac synthetase includes residues required for both nuclear targeting and enzymatic activity, [RefSeq, PubMed]; Results describe the crystal structure of the N-terminal catalytically active domain of the murine 5-N-acetylneuraminic acid synthetase in complex with the reaction product, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 13, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88719;Q8C330;Q8K2G7", "ec_number_list": [ { "id": "2.7.7.43", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.43", "type": "external" } ], "go_molecular_function": "GO:0008781 N-acylneuraminate cytidylyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0006054 N-acetylneuraminate metabolic process;GO:0006055 CMP-N-acetylneuraminate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q99KK2-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0100000000000.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C008-1", "uniprot_id": [ { "id": "DZAN1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C008", "type": "external" } ], "mass": 85025.0, "length": 778, "protein_name": "Double zinc ribbon and ankyrin repeat-containing protein 1", "gene_name": "Dzank1", "organism": "Mouse", "refseq_name": "double zinc ribbon and ankyrin repeat-containing protein 1 isoform 1", "refseq_ac": [ { "id": "NP_766447", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766447", "type": "external" } ], "gene_names_uniprotkb": "Dzank1; 6330439K17Rik", "gene_names_refseq": "2810039F03Rik; 6330439K17Rik; Ankrd64; Dzank1", "protein_names_uniprotkb": "Double zinc ribbon and ankyrin repeat-containing protein 1", "protein_names_refseq": "ankyrin repeat-containing protein C20orf12 homolog; double zinc ribbon and ankyrin repeat-containing protein 1 isoform 1; double zinc ribbon and ankyrin repeat-containing protein 1; likely ortholog of H. sapiens chromosome 20 open reading frame 12 (C20orf12)", "tax_id": 10090, "disease": "", "pathway": " (mmu:241688)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;16452087;20173027;21183079;21750661;27310661", "class_list": "", "function": "Association of a chromosomal rearrangement event with mouse posterior polymorphous corneal dystrophy and alterations in Csrp2bp, Dzank1, and Ovol2 gene expression have been reported. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in vesicle transport in photoreceptor cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AN93;Q8C060", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005929 cilium", "go_biological_process": "GO:0042462 eye photoreceptor cell development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8C008-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00375-1", "uniprot_id": [ { "id": "DYR_MOUSE", "url": "https://www.uniprot.org/uniprot/P00375", "type": "external" } ], "mass": 21606.0, "length": 187, "protein_name": "Dihydrofolate reductase", "gene_name": "Dhfr", "organism": "Mouse", "refseq_name": "dihydrofolate reductase", "refseq_ac": [ { "id": "NP_034179", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034179", "type": "external" } ], "gene_names_uniprotkb": "Dhfr", "gene_names_refseq": "8430436I03Rik; Dhfr", "protein_names_uniprotkb": "Dihydrofolate reductase; 1.5.1.3", "protein_names_refseq": "dihydrofolate reductase", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:13361); (R-MMU-196757)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "15681865;17019704;18703847;19748785;2263462;23806337;25980602;2982814;360074;36336227;37665322;6121807;6244105;6282858;6573667;762074", "class_list": "", "function": "Catalyzes the reduction of 7,8-dihydrofolate (DHF) to 5,6,7,8-tetrahydrofolate in a NADPH-dependent manner (PubMed:19748785, PubMed:25980602). Key enzyme in folate metabolism. Contributes to the nuclear and mitochondrial de novo thymidylate biosynthesis pathway (PubMed:25980602). Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (PubMed:25980602). Binds its own mRNA and that of DHFR2 (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; Dihydrofolate reductase activity controls neurogenic transitions in the developing neocortex., [RefSeq, PubMed]; Endothelial NOX4 aggravates eNOS uncoupling by decreasing dihydrofolate reductase after subarachnoid hemorrhage., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P70693;Q61485;Q61487;Q61579", "ec_number_list": [ { "id": "1.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.3", "type": "external" } ], "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity;GO:1990825 sequence-specific mRNA binding;GO:0004146 dihydrofolate reductase activity;GO:0060090 molecular adaptor activity;GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0046654 tetrahydrofolate biosynthetic process;GO:0046655 folic acid metabolic process;GO:0031427 response to methotrexate;GO:0006729 tetrahydrobiopterin biosynthetic process;GO:0031103 axon regeneration", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P00375-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61501-1", "uniprot_id": [ { "id": "E2F1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61501", "type": "external" } ], "mass": 46323.0, "length": 430, "protein_name": "Transcription factor E2F1", "gene_name": "E2f1", "organism": "Mouse", "refseq_name": "transcription factor E2F1 isoform a", "refseq_ac": [ { "id": "NP_031917", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031917", "type": "external" } ], "gene_names_uniprotkb": "E2f1", "gene_names_refseq": "E2F-1; E2f1; Tg(Wnt1-cre)2Sor; mKIAA4009", "protein_names_uniprotkb": "Transcription factor E2F1; E2F-1", "protein_names_refseq": "transcription factor E2F1 isoform a; transcription factor E2F1", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); urinary bladder cancer (Disease Ontology:DOID:11054); Huntington's disease (Disease Ontology:DOID:12858); Sjogren's syndrome (Disease Ontology:DOID:12894); dementia (Disease Ontology:DOID:1307); pancreatic cancer (Disease Ontology:DOID:1793); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); osteosarcoma (Disease Ontology:DOID:3347); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); lung small cell carcinoma (Disease Ontology:DOID:5409); viral encephalitis (Disease Ontology:DOID:646); chronic myeloid leukemia (Disease Ontology:DOID:8552); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:13555); (R-MMU-68911); (R-MMU-69231)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "11459832;11672531;15716352;20176812;20680651;20940255;24741006;25428506;31666529;36689330;8114719;8336704;9376316;9674698", "class_list": "", "function": "Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication (PubMed:11672531, PubMed:20176812, PubMed:9674698). The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase (By similarity). E2F1 binds preferentially RB1 in a cell-cycle dependent manner (By similarity). It can mediate both cell proliferation and TP53/p53-dependent apoptosis (PubMed:9674698). Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:11672531, PubMed:20176812). Directly activates transcription of PEG10 (By similarity). Positively regulates transcription of RRP1B (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 19, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80VZ3", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0019901 protein kinase binding;GO:0046983 protein dimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0070345 negative regulation of fat cell proliferation;GO:1990086 lens fiber cell apoptotic process;GO:0060252 positive regulation of glial cell proliferation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q61501-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2R9-1", "uniprot_id": [ { "id": "E2AK1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z2R9", "type": "external" } ], "mass": 69702.0, "length": 619, "protein_name": "Eukaryotic translation initiation factor 2-alpha kinase 1", "gene_name": "Eif2ak1", "organism": "Mouse", "refseq_name": "eukaryotic translation initiation factor 2-alpha kinase 1 isoform 1", "refseq_ac": [ { "id": "NP_038585", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038585", "type": "external" } ], "gene_names_uniprotkb": "Eif2ak1; Hri", "gene_names_refseq": "Eif2ak1; HCR; Hri", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 2-alpha kinase 1; 2.7.11.1; HCR; Heme-controlled repressor; Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase; Heme-regulated inhibitor; Hemin-sensitive initiation factor 2-alpha kinase", "protein_names_refseq": "eukaryotic translation initiation factor 2-alpha kinase 1 isoform 1; heme-controlled repressor; heme-regulated eukaryotic initiation factor eIF-2-alpha kinase; heme-regulated inhibitor; hemin-sensitive initiation factor 2-alpha kinase", "tax_id": 10090, "disease": "", "pathway": " (mmu:15467); (R-MMU-9840373)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "11050009;11560503;11689689;11726526;12767237;14752110;15931390;16893190;17932563;20071449;20173027;25428506;27802388;30084848;30779550;33168630;33795747;34428180;9822714", "class_list": "", "function": "Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions (PubMed:11726526, PubMed:12767237, PubMed:16893190). Key activator of the integrated stress response (ISR) required for adaptation to various stress, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock (PubMed:11726526, PubMed:16893190). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming (PubMed:11726526, PubMed:16893190). Acts as a key sensor of heme-deficiency: in normal conditions, binds hemin via a cysteine thiolate and histidine nitrogenous coordination, leading to inhibit the protein kinase activity (PubMed:16893190). This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell: heme depletion relieves inhibition and stimulates kinase activity, activating the ISR (PubMed:16893190). Thanks to this unique heme-sensing capacity, plays a crucial role to shut off protein synthesis during acute heme-deficient conditions (PubMed:16893190). In red blood cells (RBCs), controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties (PubMed:11050009, PubMed:11726526, PubMed:15931390). It thereby plays an essential protective role for RBC survival in anemias of iron deficiency (PubMed:11726526). Iron deficiency also triggers activation by full-length DELE1 (By similarity). Also activates the ISR in response to mitochondrial dysfunction: HRI/EIF2AK1 protein kinase activity is activated upon binding to the processed form of DELE1 (S-DELE1), thereby promoting the ATF4-mediated reprogramming (By similarity). Also acts as an activator of mitophagy in response to mitochondrial damage: catalyzes phosphorylation of eIF-2-alpha (EIF2S1) following activation by S-DELE1, thereby promoting mitochondrial localization of EIF2S1, triggering PRKN-independent mitophagy (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; The eIF2alpha kinase HRI triggers the autophagic clearance of cytosolic protein aggregates., [RefSeq, PubMed]; Wnt5a promotes hippocampal postsynaptic development and GluN2B-induced expression via the eIF2alpha HRI kinase. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2TA96;Q69ZK8;Q8C024;Q8K123;Q9CTP5;Q9D601", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity;GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0020037 heme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0070585 protein localization to mitochondrion;GO:1901526 positive regulation of mitophagy;GO:0006417 regulation of translation;GO:0008285 negative regulation of cell population proliferation;GO:0006909 phagocytosis", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9Z2R9-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQ20-1", "uniprot_id": [ { "id": "MMSA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EQ20", "type": "external" } ], "mass": 57916.0, "length": 535, "protein_name": "Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial", "gene_name": "Aldh6a1", "organism": "Mouse", "refseq_name": "methylmalonate-semialdehyde/malonate- semialdehyde dehydrogenase [acylating], mitochondrial isoform 1 precursor", "refseq_ac": [ { "id": "NP_598803", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598803", "type": "external" } ], "gene_names_uniprotkb": "Aldh6a1", "gene_names_refseq": "1110038I05Rik; Aldh6a1; Mmsdh", "protein_names_uniprotkb": "Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial; 1.2.1.27; Aldehyde dehydrogenase family 6 member A1; MMSDH; Malonate-semialdehyde dehydrogenase [acylating]", "protein_names_refseq": "aldehyde dehydrogenase family 6 member A1; malonate-semialdehyde dehydrogenase; methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial; methylmalonate-semialdehyde/malonate- semialdehyde dehydrogenase [acylating], mitochondrial isoform 1 precursor; methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:104776); (R-MMU-70895)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;21750661;23576753;23806337;30084848;34428180;36288343;37453647;37507081;39927985", "class_list": "", "function": "Malonate and methylmalonate semialdehyde dehydrogenase involved in the catabolism of valine, thymine, and compounds catabolized by way of beta-alanine, including uracil and cytidine., [UniProtKB, UniProtKB]; This gene encodes a member of the aldehyde dehydrogenase protein family. The encoded enzyme is a mitochondrial methylmalonate semialdehyde dehydrogenase that plays a role in the valine and pyrimidine catabolic pathways. This enzyme catalyzes the irreversible oxidative decarboxylation of malonate and methylmalonate semialdehydes to acetyl- and propionyl-CoA. Mutations in the human gene result in Methylmalonate Semialdehyde Dehydrogenase Deficiency, characterized by elevated beta-alanine, 3-hydroxypropionic acid, and both isomers of 3-amino and 3-hydroxyisobutyric acids in urine organic acids. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TDA2;Q8CIB4", "ec_number_list": [ { "id": "1.2.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.27", "type": "external" } ], "go_molecular_function": "GO:0016790 thiolester hydrolase activity;GO:0004491 methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006210 thymine catabolic process;GO:0050873 brown fat cell differentiation;GO:0006574 L-valine catabolic process;GO:0006573 valine metabolic process;GO:0019859 thymine metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9EQ20-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DC61-1", "uniprot_id": [ { "id": "MPPA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DC61", "type": "external" } ], "mass": 58279.0, "length": 524, "protein_name": "Mitochondrial-processing peptidase subunit alpha", "gene_name": "Pmpca", "organism": "Mouse", "refseq_name": "mitochondrial-processing peptidase subunit alpha isoform a precursor", "refseq_ac": [ { "id": "NP_775272", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775272", "type": "external" } ], "gene_names_uniprotkb": "Pmpca; Inpp5e", "gene_names_refseq": "1200002L24Rik; 4933435E07Rik; Alpha-MPP; P-55; Pmpca", "protein_names_uniprotkb": "Mitochondrial-processing peptidase subunit alpha; Alpha-MPP; Inactive zinc metalloprotease alpha; P-55", "protein_names_refseq": "inactive zinc metalloprotease alpha; mitochondrial matrix processing protease, alpha subunit; mitochondrial-processing peptidase subunit alpha isoform a precursor; mitochondrial-processing peptidase subunit alpha", "tax_id": 10090, "disease": "autosomal recessive spinocerebellar ataxia 2 (Disease Ontology:DOID:0080061)", "pathway": " (mmu:66865); (R-MMU-8949664); (R-MMU-9837999)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "19656850;21750661;23576753;23806337;24129315;24903103;28135057;31219806;34428180;37507081", "class_list": "", "function": "Data show that Afg3l1 or Afg3l2 are required for maturation of newly imported paraplegin subunits after their cleavage by MPP., [RefSeq, PubMed]; OxLDL triggers retrograde translocation of arginase2 in aortic endothelial cells via ROCK and mitochondrial processing peptidase., [RefSeq, PubMed]; Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TF19", "ec_number_list": [], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0017087 mitochondrial processing peptidase complex;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0016485 protein processing;GO:0006627 protein processing involved in protein targeting to mitochondrion;GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9DC61-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53986-1", "uniprot_id": [ { "id": "MOT1_MOUSE", "url": "https://www.uniprot.org/uniprot/P53986", "type": "external" } ], "mass": 53267.0, "length": 493, "protein_name": "Monocarboxylate transporter 1", "gene_name": "Slc16a1", "organism": "Mouse", "refseq_name": "monocarboxylate transporter 1", "refseq_ac": [ { "id": "NP_033222", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033222", "type": "external" } ], "gene_names_uniprotkb": "Slc16a1; Mct1", "gene_names_refseq": "Mct1; Slc16a1", "protein_names_uniprotkb": "Monocarboxylate transporter 1; MCT 1; Solute carrier family 16 member 1", "protein_names_refseq": "monocarboxylate transporter 1; solute carrier family 16 member 1", "tax_id": 10090, "disease": "familial hyperinsulinemic hypoglycemia 7 (Disease Ontology:DOID:0070214); lymphangioleiomyomatosis (Disease Ontology:DOID:3319)", "pathway": " (mmu:20501); (R-MMU-210991); (R-MMU-433692); (R-MMU-9749641)", "pathway_count": 4, "publication_count": 24, "publication_id_list": "17114649;17208939;17242355;18630941;19131326;19144319;21183079;21792931;22522610;24367518;25428506;25605945;30084848;30779550;31219806;32946811;34428180;36210013;36288343;37453647;37828378;39927985;8603082;9725820", "class_list": "", "function": "Bidirectional proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, acetate and the ketone bodies acetoacetate and beta-hydroxybutyrate, and thus contributes to the maintenance of intracellular pH (By similarity). The transport direction is determined by the proton motive force and the concentration gradient of the substrate monocarboxylate. MCT1 is a major lactate exporter (By similarity). Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis (PubMed:22522610, PubMed:24367518). Facilitates the protonated monocarboxylate form of succinate export, that its transient protonation upon muscle cell acidification in exercising muscle and ischemic heart. Functions via alternate outward- and inward-open conformation states. Protonation and deprotonation of 302-Asp is essential for the conformational transition (PubMed:32946811)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0015295 solute:proton symporter activity;GO:0046943 carboxylic acid transmembrane transporter activity;GO:0008028 monocarboxylic acid transmembrane transporter activity;GO:0015129 lactate transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005813 centrosome;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0030054 cell junction", "go_biological_process": "GO:0035873 lactate transmembrane transport;GO:0006629 lipid metabolic process;GO:0032094 response to food;GO:0042593 glucose homeostasis;GO:0050796 regulation of insulin secretion", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P53986-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U9N9-1", "uniprot_id": [ { "id": "MOT10_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U9N9", "type": "external" } ], "mass": 55320.0, "length": 512, "protein_name": "Monocarboxylate transporter 10", "gene_name": "Slc16a10", "organism": "Mouse", "refseq_name": "monocarboxylate transporter 10 isoform 1", "refseq_ac": [ { "id": "NP_001107804", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107804", "type": "external" } ], "gene_names_uniprotkb": "Slc16a10; Mct10; Tat1", "gene_names_refseq": "2610103N14Rik; 9830169E08; Mct10; PRO0813; Slc16a10; TAT1", "protein_names_uniprotkb": "Monocarboxylate transporter 10; Aromatic amino acid transporter 1; MCT 10; Solute carrier family 16 member 10; T-type amino acid transporter 1", "protein_names_refseq": "MCT 10; T-type amino acid transporter 1; aromatic amino acid transporter 1; monocarboxylate transporter 10 isoform 1; monocarboxylate transporter 10; solute carrier family 16 member 10", "tax_id": 10090, "disease": "esophagus squamous cell carcinoma (Disease Ontology:DOID:3748)", "pathway": " (mmu:72472); (R-MMU-352230)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "16245314;17242355;17273864;19144319;21183079;21750661;23045339;24994998;34071318;34669927;38396788", "class_list": "", "function": "Sodium- and proton-independent thyroid hormones and aromatic acids transporter. Mediates both uptake and efflux of 3,5,3'-triiodothyronine (T3) and 3,5,3',5'-tetraiodothyronine (T4) with high affinity, suggesting a role in the homeostasis of thyroid hormone levels (By similarity). Responsible for low affinity bidirectional transport of the aromatic amino acids, such as phenylalanine, tyrosine, tryptophan and L-3,4-dihydroxyphenylalanine (L-dopa) (PubMed:16245314). Plays an important role in homeostasis of aromatic amino acids (PubMed:23045339)., [UniProtKB, PubMed, PubMed, UniProtKB]; TAT1 is a basolateral epithelial transporter and can function as a net efflux pathway for aromatic amino acids. We propose that it may supply parallel exchangers with recycling uptake substrates that could drive the efflux of other amino acids., [RefSeq, PubMed]; The Amino Acid Transporter Mct10/Tat1 Is Important to Maintain the TSH Receptor at Its Canonical Basolateral Localization and Assures Regular Turnover of Thyroid Follicle Cells in Male Mice. Publication Status: Online-Only, [RefSeq, PubMed]; The Differential Effect of a Shortage of Thyroid Hormone Compared with Knockout of Thyroid Hormone Transporters Mct8 and Mct10 on Murine Macrophage Polarization. Publication Status: Online-Only, [RefSeq, PubMed]; The Thyroid Hormone Transporter MCT10 Is a Novel Regulator of Trabecular Bone Mass and Bone Turnover in Male Mice., [RefSeq, PubMed]; The aromatic amino acid diffusion pathway TAT1 can control neutral amino acid efflux via neighboring exchanger LAT2-4F2hc, by recycling its aromatic influx substrates, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TNJ1;Q3UAN9;Q8BWR7", "ec_number_list": [], "go_molecular_function": "GO:0015196 L-tryptophan transmembrane transporter activity;GO:0022857 transmembrane transporter activity;GO:0015173 aromatic amino acid transmembrane transporter activity;GO:0015349 thyroid hormone transmembrane transporter activity;GO:0005302 L-tyrosine transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0030054 cell junction", "go_biological_process": "GO:0006590 thyroid hormone generation;GO:0070460 thyroid-stimulating hormone secretion;GO:0015801 aromatic amino acid transport;GO:0070327 thyroid hormone transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q3U9N9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PGF2-1", "uniprot_id": [ { "id": "MORN4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PGF2", "type": "external" } ], "mass": 16206.0, "length": 146, "protein_name": "MORN repeat-containing protein 4", "gene_name": "Morn4", "organism": "Mouse", "refseq_name": "MORN repeat-containing protein 4", "refseq_ac": [ { "id": "NP_932776", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932776", "type": "external" } ], "gene_names_uniprotkb": "Morn4", "gene_names_refseq": "Morn4", "protein_names_uniprotkb": "MORN repeat-containing protein 4", "protein_names_refseq": "MORN repeat-containing protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:226123)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22496551;26754646;36682578", "class_list": "", "function": "MORN4 protects cardiomyocytes against ischemic injury via MFN2-mediated mitochondrial dynamics and mitophagy., [RefSeq, PubMed]; Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0042995 cell projection;GO:0032433 filopodium tip;GO:0032426 stereocilium tip", "go_biological_process": "GO:0048678 response to axon injury", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6PGF2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QVP4-1", "uniprot_id": [ { "id": "MLRA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QVP4", "type": "external" } ], "mass": 19450.0, "length": 175, "protein_name": "Myosin regulatory light chain 2, atrial isoform", "gene_name": "Myl7", "organism": "Mouse", "refseq_name": "myosin regulatory light chain 2, atrial isoform", "refseq_ac": [ { "id": "NP_075017", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075017", "type": "external" } ], "gene_names_uniprotkb": "Myl7; Mylc2a", "gene_names_refseq": "MLC-2alpha; MLC2a; MYL2A; Myl7; Mylc2a; RLC-A", "protein_names_uniprotkb": "Myosin regulatory light chain 2, atrial isoform; MLC-2a; MLC2a; Myosin light chain 2a; Myosin regulatory light chain 7", "protein_names_refseq": "MLC-2a; myosin light chain 2a; myosin light chain, regulatory A; myosin regulatory light chain 2, atrial isoform; myosin regulatory light chain 7", "tax_id": 10090, "disease": "hypertrophic cardiomyopathy 10 (Disease Ontology:DOID:0110316)", "pathway": " (mmu:17898); (R-MMU-445355)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11124527;21183079;30084848;37507081;8207020;8777429", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q63977;Q9JIE8", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0043197 dendritic spine;GO:0030016 myofibril;GO:0031672 A band;GO:0016459 myosin complex", "go_biological_process": "GO:0060047 heart contraction;GO:0048738 cardiac muscle tissue development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9QVP4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O09130-1", "uniprot_id": [ { "id": "NF2IP_MOUSE", "url": "https://www.uniprot.org/uniprot/O09130", "type": "external" } ], "mass": 45121.0, "length": 412, "protein_name": "NFATC2-interacting protein", "gene_name": "Nfatc2ip", "organism": "Mouse", "refseq_name": "NFATC2-interacting protein isoform 1", "refseq_ac": [ { "id": "NP_035030", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035030", "type": "external" } ], "gene_names_uniprotkb": "Nfatc2ip; Nip45", "gene_names_refseq": "D7Ertd304e; NIP45; Nfatc2ip", "protein_names_uniprotkb": "NFATC2-interacting protein; 45 kDa NF-AT-interacting protein; 45 kDa NFAT-interacting protein; Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein", "protein_names_refseq": "45 kDa NF-AT-interacting protein; 45 kDa NFAT-interacting protein; NFATC2-interacting protein isoform 1; NFATC2-interacting protein; nuclear factor of activated T-cells, cytoplasmic 2-interacting protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:18020)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "11435475;15327772;16352630;17242355;20077568;20133688;21183079;21750661;22105856;23159618;31666531;8943202", "class_list": "", "function": "Data report a role for arginine methylation of NIP45 in regulating cytokine gene transcription in the T helper lymphocyte., [RefSeq, PubMed]; In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression. Down-regulates formation of poly-SUMO chains by UBE2I/UBC9., [UniProtKB, PubMed, PubMed]; Results indicate that RANKL signaling down regulates NIP45 expression and that NIP45 is a negative regulator of osteoclast differentiation, [RefSeq, PubMed]; Targeted deletion of NFAT-Interacting-Protein-(NIP) 45 resolves experimental asthma by inhibiting Innate Lymphoid Cells group 2 (ILC2). Publication Status: Online-Only, [RefSeq, PubMed]; Under standard, non-stressful conditions, FLAG-mNip45 diffusely distributed in the nucleus., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8CDG2;Q9CVY5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O09130-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5DTT1-1", "uniprot_id": [ { "id": "NEXMI_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5DTT1", "type": "external" } ], "mass": 167102.0, "length": 1515, "protein_name": "Neurite extension and migration factor", "gene_name": "Nexmif", "organism": "Mouse", "refseq_name": "neurite extension and migration factor", "refseq_ac": [ { "id": "NP_001070822", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070822", "type": "external" } ], "gene_names_uniprotkb": "Nexmif; Kiaa2022", "gene_names_refseq": "A230051P11; KIDLIA; Nexmif; Xpn", "protein_names_uniprotkb": "Neurite extension and migration factor; KIAA2022 protein associated with intellectual disability, language impairment and autistic behavior homolog; KIDLIA", "protein_names_refseq": "XLMR protein related to neurite extension; neurite extension and migration factor", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); non-syndromic X-linked intellectual disability 98 (Disease Ontology:DOID:0112044)", "pathway": " (mmu:245555)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "19524067;22531377;27822498;30084848;31704787;34887587;35820727;40885482", "class_list": "", "function": "Ale NEXMIF KO mice demonstrate reduced sociability and communication, elevated repetitive grooming behavior, and deficits in learning and memory. Loss of NEXMIF/KIDLIA expression results in a significant decrease in synapse density and synaptic protein expression. Male KO animals show aberrant synaptic function as measured by excitatory miniatures and postsynaptic currents in the hippocampus., [RefSeq, PubMed]; Involved in neurite outgrowth by regulating cell-cell adhesion via the N-cadherin signaling pathway. May act by regulating expression of protein-coding genes, such as N-cadherins and integrin beta-1 (ITGB1)., [UniProtKB, PubMed]; Knockdown of KIAA2022/KIDLIA leads to altered neuron migration and a reduction in dendritic growth and disorganized apical dendrite projections in layer II/III cortical neurons. In cultured neurons loss of KIDLIA expression also leads to suppression of dendritic growth and branching. KIDLIA suppression leads to an increase in cell-surface N-cadherin and an elevated association of N-cadherin with delta-catenin. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q003Y8;Q8BW26;Q8BYR0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0030496 midbody", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007399 nervous system development;GO:0001953 negative regulation of cell-matrix adhesion;GO:0033629 negative regulation of cell adhesion mediated by integrin;GO:2001223 negative regulation of neuron migration", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q5DTT1-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6R891-1", "uniprot_id": [ { "id": "NEB2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6R891", "type": "external" } ], "mass": 89520.0, "length": 817, "protein_name": "Neurabin-2", "gene_name": "Ppp1r9b", "organism": "Mouse", "refseq_name": "neurabin-2", "refseq_ac": [ { "id": "NP_758465", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_758465", "type": "external" } ], "gene_names_uniprotkb": "Ppp1r9b", "gene_names_refseq": "Ppp1r9b; SPL; Spn", "protein_names_uniprotkb": "Neurabin-2; Neurabin-II; Protein phosphatase 1 regulatory subunit 9B; Spinophilin", "protein_names_refseq": "neurabin-2; neurabin-II; spinophilin", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); Parkinson's disease (Disease Ontology:DOID:14330); schizophrenia (Disease Ontology:DOID:5419); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:217124)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;12738775;14550532;15728359;16300646;16628014;17826804;19144319;22210881;26407691;28634551;31219806;34428180;34887587;36210013;36822932;38630048;40684658", "class_list": "", "function": "Mechanisms of spinophilin-dependent pancreas dysregulation in obesity., [RefSeq, PubMed]; Role in stabilizing cell surface expression of alpha 2B-adrenergic receptors, [RefSeq, PubMed]; Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Plays a role in regulation of G protein-coupled receptor signaling, including dopamine D2 receptors and alpha-adrenergic receptors. May establish a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Binds to ADRA1B and RGS2 and mediates regulation of ADRA1B signaling. May confer to Rac signaling specificity by binding to both, RacGEFs and Rac effector proteins. Probably regulates p70 S6 kinase activity by forming a complex with TIAM1. Required for hepatocyte growth factor (HGF)-induced cell migration (By similarity)., [UniProtKB]; Spinophilin Limits Metabotropic Glutamate Receptor 5 Scaffolding to the Postsynaptic Density and Cell Type Specifically Mediates Excessive Grooming., [RefSeq, PubMed]; The coiled-coil domain of neurabin II binds to a DCX region encompassing the C-terminal portion of the second DCX repeat and the N-terminal portion of the Ser/Pro-rich domain., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8K0X7", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0004672 protein kinase activity;GO:0051015 actin filament binding;GO:0044325 transmembrane transporter binding;GO:0019900 kinase binding", "go_cellular_component": "GO:1990780 cytoplasmic side of dendritic spine plasma membrane;GO:0098978 glutamatergic synapse;GO:0098890 extrinsic component of postsynaptic membrane;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0003006 developmental process involved in reproduction;GO:1903119 protein localization to actin cytoskeleton;GO:1904372 positive regulation of protein localization to actin cortical patch;GO:1904386 response to L-phenylalanine derivative;GO:0060179 male mating behavior", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q6R891-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EPN1-1", "uniprot_id": [ { "id": "NBEA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EPN1", "type": "external" } ], "mass": 326743.0, "length": 2936, "protein_name": "Neurobeachin", "gene_name": "Nbea", "organism": "Mouse", "refseq_name": "neurobeachin", "refseq_ac": [ { "id": "NP_085098", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_085098", "type": "external" } ], "gene_names_uniprotkb": "Nbea; Lyst2", "gene_names_refseq": "Lyst2; Nbea; mKIAA1544", "protein_names_uniprotkb": "Neurobeachin; Lysosomal-trafficking regulator 2", "protein_names_refseq": "lysosomal trafficking regulator 2; neurobeachin", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); stomach cancer (Disease Ontology:DOID:10534)", "pathway": " (mmu:26422)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "10.1101/2023.09.13.557529;11102458;12160729;17114649;21183079;21750661;22517741;22645316;22872234;25428506;30084848;31219806;32848054;33300544;34203471;34418053;34428180;34678516;35822049;37506311;40021952;40885482", "class_list": "", "function": "Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins. May have a role in membrane trafficking., [UniProtKB, PubMed]; Neurobeachin haploinsufficient mice display sex-independent alterations in cued and contextual fear conditioning., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 20, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 20, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 20, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 11, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 2, "glyco_site_count": 26, "binding_glycan_count": 0, "secondary_ac_list": "Q8C931;Q9EPM9;Q9EPN0;Q9WVM9", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0051018 protein kinase A binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0098890 extrinsic component of postsynaptic membrane;GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0050808 synapse organization;GO:0006605 protein targeting;GO:0008104 intracellular protein localization;GO:0006892 post-Golgi vesicle-mediated transport;GO:0098696 regulation of neurotransmitter receptor localization to postsynaptic specialization membrane", "synthesized_glycan_count": 0, "hit_score": 5.4, "record_id": "Q9EPN1-1", "record_type": "protein", "filter_code": "0000000.1000111.001000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ERR1-1", "uniprot_id": [ { "id": "NDEL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ERR1", "type": "external" } ], "mass": 38366.0, "length": 345, "protein_name": "Nuclear distribution protein nudE-like 1", "gene_name": "Ndel1", "organism": "Mouse", "refseq_name": "nuclear distribution protein nudE-like 1 isoform 1", "refseq_ac": [ { "id": "NP_076157", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076157", "type": "external" } ], "gene_names_uniprotkb": "Ndel1; Nudel", "gene_names_refseq": "2600006O07Rik; MITAP1; NUDEL; Ndel1; mNudE-L; mNudel", "protein_names_uniprotkb": "Nuclear distribution protein nudE-like 1; Protein Nudel; Protein mNudE-like; mNudE-L", "protein_names_refseq": "nuclear disribution gene E like; nuclear distribution gene E-like homolog 1; nuclear distribution protein nudE-like 1 isoform 1; nuclear distribution protein nudE-like 1; protein Nudel", "tax_id": 10090, "disease": "lissencephaly (Disease Ontology:DOID:0050453); epilepsy (Disease Ontology:DOID:1826); Rubinstein-Taybi syndrome (Disease Ontology:DOID:1933); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:83431); (R-MMU-141430); (R-MMU-141444); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-5663220); (R-MMU-68877); (R-MMU-9648025)", "pathway_count": 8, "publication_count": 22, "publication_id_list": "11163259;11163260;11231056;12796778;14962739;15147871;15208636;15473966;15473967;15797709;16107726;16203747;17242355;18809722;21183079;25698733;27333658;27777970;28315936;31219806;34319758;34428180", "class_list": "", "function": "Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (PubMed:27777970). Plays a role, together with DISC1, in the regulation of neurite outgrowth (By similarity). May act as a RAB9A/B effector that tethers RAB9-associated late endosomes to the dynein motor for their retrograde transport to the trans-Golgi network (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, PubMed]; Roles for Ndel1 in keratin organization and desmosome function., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D0Q4;Q9EPT6", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0048487 beta-tubulin binding;GO:0043014 alpha-tubulin binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005813 centrosome;GO:0005819 spindle;GO:0005874 microtubule;GO:0030424 axon", "go_biological_process": "GO:0048680 positive regulation of axon regeneration;GO:0021799 cerebral cortex radially oriented cell migration;GO:0008090 retrograde axonal transport;GO:0007059 chromosome segregation;GO:0016477 cell migration", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q9ERR1-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31649-1", "uniprot_id": [ { "id": "S6A13_MOUSE", "url": "https://www.uniprot.org/uniprot/P31649", "type": "external" } ], "mass": 68285.0, "length": 602, "protein_name": "Sodium- and chloride-dependent GABA transporter 2", "gene_name": "Slc6a13", "organism": "Mouse", "refseq_name": "sodium- and chloride-dependent GABA transporter 2 isoform a", "refseq_ac": [ { "id": "NP_653095", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_653095", "type": "external" } ], "gene_names_uniprotkb": "Slc6a13; Gabt2; Gabt3; Gat-3; Gat2; Gat3", "gene_names_refseq": "GAT3; Gabt3; Gat2; Slc6a13", "protein_names_uniprotkb": "Sodium- and chloride-dependent GABA transporter 2; GAT-2; GAT-3; Sodium- and chloride-dependent GABA transporter 3; Solute carrier family 6 member 13", "protein_names_refseq": "GAT-2; GAT-3; gamma-aminobutyric acid (GABA-A) transporter 3; sodium- and chloride-dependent GABA transporter 2 isoform a; sodium- and chloride-dependent GABA transporter 2; sodium- and chloride-dependent GABA transporter 3; solute carrier family 6 member 13", "tax_id": 10090, "disease": "", "pathway": " (mmu:14412); (R-MMU-442660); (R-MMU-888593)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "17242355;21183079;21750661;22896705;25605945;30084848;30270321;30779550;34428180;35797984;8420981", "class_list": "", "function": "Mediates sodium- and chloride-dependent transport of gamma-aminobutyric acid (GABA) (PubMed:22896705, PubMed:30270321, PubMed:8420981). Can also mediate transport of beta-alanine, taurine and hypotaurine and is the major taurine transporter in hepatocytes (PubMed:22896705, PubMed:30270321, PubMed:8420981)., [UniProtKB, PubMed, PubMed, PubMed]; Slc6a13 Deficiency Attenuates Pasteurella multocida Infection-Induced Inflammation via Glycine-Inflammasome Signaling., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005332 gamma-aminobutyric acid:sodium:chloride symporter activity;GO:0016597 amino acid binding;GO:0015171 amino acid transmembrane transporter activity;GO:0005283 amino acid:sodium symporter activity;GO:0005369 taurine:sodium symporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0042995 cell projection;GO:0016020 membrane", "go_biological_process": "GO:0006865 amino acid transport;GO:0035725 sodium ion transmembrane transport;GO:0015734 taurine transmembrane transport;GO:0015881 creatine transmembrane transport;GO:0051939 gamma-aminobutyric acid import", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P31649-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5DTL9-1", "uniprot_id": [ { "id": "S4A10_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5DTL9", "type": "external" } ], "mass": 125817.0, "length": 1118, "protein_name": "Sodium-driven chloride bicarbonate exchanger", "gene_name": "Slc4a10", "organism": "Mouse", "refseq_name": "sodium-driven chloride bicarbonate exchanger isoform 4", "refseq_ac": [ { "id": "NP_001229309", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001229309", "type": "external" } ], "gene_names_uniprotkb": "Slc4a10; Kiaa4136; Ncbe", "gene_names_refseq": "NCBE; Slc4a10; mKIAA4136", "protein_names_uniprotkb": "Sodium-driven chloride bicarbonate exchanger; Solute carrier family 4 member 10", "protein_names_refseq": "sodium bicarbonate cotransporter NBCn2-E; sodium bicarbonate cotransporter member 10 variant NBCn2-E'; sodium-driven chloride bicarbonate exchanger isoform 4; sodium-driven chloride bicarbonate exchanger", "tax_id": 10090, "disease": "anemia (Disease Ontology:DOID:2355)", "pathway": " (mmu:94229); (R-MMU-425381)", "pathway_count": 2, "publication_count": 22, "publication_id_list": "10.1101/2023.09.13.557529;10993873;14592810;15567717;16452087;17114649;17928512;18061361;18165320;20541593;20566632;21183079;21439947;23056253;23409100;24905082;26136660;28935959;37459438;37828581;38054405;38674160", "class_list": "", "function": "Biallelic variants in SLC4A10 encoding a sodium-dependent bicarbonate transporter lead to a neurodevelopmental disorder., [RefSeq, PubMed]; In vitro investigation of the effect of proinflammatory cytokines on mouse choroid plexus membrane transporters Ncbe and NKCC1. Publication Status: Online-Only, [RefSeq, PubMed]; K[+]-Driven Cl[-]/HCO3[-] Exchange Mediated by Slc4a8 and Slc4a10. Publication Status: Online-Only, [RefSeq, PubMed]; NCBE is expressed in the peripheral nervous system and in non-neuronal tissues as the choroid plexus, the dura, and some epithelia including the acid secreting epithelium of the stomach and the duodenal epithelium., [RefSeq, PubMed]; SLC4A10 gene product and NBCn1 both function as basolateral HCO3- entry pathways and that the SLC4A10 gene product may be responsible for the stilbene-sensitive Na+-HCO3- uptake that is essential for cerebrospinal fluid production., [RefSeq, PubMed]; SLC4A10 mutation causes a neurological disorder associated with impaired GABAergic transmission., [RefSeq, PubMed]; Sodium/bicarbonate cotransporter which mediates cotransport of sodium and bicarbonate in association with an efflux of intracellular chloride., [UniProtKB, PubMed]; Sodium/bicarbonate cotransporter which plays an important role in regulating intracellular pH (PubMed:20566632). Has been shown to act as a sodium/bicarbonate cotransporter in exchange for intracellular chloride (PubMed:20566632). Has also been shown to act as a sodium/biocarbonate cotransporter which is not responsible for net efflux of chloride, with the observed chloride efflux being due to chloride self-exchange (By similarity). Controls neuronal pH and may contribute to the secretion of cerebrospinal fluid (PubMed:18165320). Acting on presynaptic intracellular pH, it promotes GABA release, reduces the excitability of CA1 pyramidal neurons, and modulates short-term synaptic plasticity (PubMed:26136660, PubMed:37459438). Required in retinal cells to maintain normal pH which is necessary for normal vision (PubMed:23056253). In the kidney, likely to mediate bicarbonate reclamation in the apical membrane of the proximal tubules (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "E9NX85;F1DFN1;G3F8Y7;G3F8Y8;G3F8Y9;G3F8Z0;I6VS12;J7K287;Q8CFS3;Q9EST0", "ec_number_list": [], "go_molecular_function": "GO:0008510 sodium:bicarbonate symporter activity;GO:0140892 sodium,bicarbonate:chloride antiporter activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0048172 regulation of short-term neuronal synaptic plasticity;GO:0055085 transmembrane transport;GO:0009101 glycoprotein biosynthetic process;GO:0035264 multicellular organism growth;GO:0007601 visual perception", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q5DTL9-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CCI5-1", "uniprot_id": [ { "id": "RYBP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CCI5", "type": "external" } ], "mass": 24777.0, "length": 228, "protein_name": "RING1 and YY1-binding protein", "gene_name": "Rybp", "organism": "Mouse", "refseq_name": "RING1 and YY1-binding protein", "refseq_ac": [ { "id": "NP_062717", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062717", "type": "external" } ], "gene_names_uniprotkb": "Rybp; Dedaf", "gene_names_refseq": "2410018J24Rik; DEDAF; Rybp; YEAF1", "protein_names_uniprotkb": "RING1 and YY1-binding protein; DED-associated factor; Death effector domain-associated factor", "protein_names_refseq": "DED-associated factor; RING1 and YY1-binding protein; Ring1 interactor Rybp; death effector domain-associated factor", "tax_id": 10090, "disease": "", "pathway": " (mmu:56353); (R-MMU-8939243); (R-MMU-8953750)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "10369680;14765135;16055728;17070805;17874297;19170609;21183079;22226355;22325148;27748911;28596365;36751888;37196079;37935677", "class_list": "", "function": "Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:22325148, PubMed:28596365). Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (PubMed:28596365). May stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites (PubMed:22325148, PubMed:28596365). Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes (By similarity). May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis (PubMed:17874297). May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1 (By similarity). May bind to DNA (PubMed:19170609). May play a role in the repression of tumor growth and metastasis in breast cancer by down-regulating SRRM3 (PubMed:27748911)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Functional dissection of PRC1 subunits RYBP and YAF2 during neural differentiation of embryonic stem cells. Publication Status: Online-Only, [RefSeq, PubMed]; Polycomb protein RYBP activates transcription factor Plagl1 during in vitro cardiac differentiation of mouse embryonic stem cells., [RefSeq, PubMed]; Rybp/DEDAF is required for early postimplantation and for central nervous system development, [RefSeq, PubMed]; USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RRB6;Q9WVK2", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity;GO:0003676 nucleic acid binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0031519 PcG protein complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0043065 positive regulation of apoptotic process;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8CCI5-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62419-1", "uniprot_id": [ { "id": "SH3G1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62419", "type": "external" } ], "mass": 41518.0, "length": 368, "protein_name": "Endophilin-A2", "gene_name": "Sh3gl1", "organism": "Mouse", "refseq_name": "endophilin-A2 isoform 1", "refseq_ac": [ { "id": "NP_038692", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038692", "type": "external" } ], "gene_names_uniprotkb": "Sh3gl1; Sh3d2b", "gene_names_refseq": "EEN; SH3P8; Sh3d2b; Sh3gl1", "protein_names_uniprotkb": "Endophilin-A2; Endophilin-2; SH3 domain protein 2B; SH3 domain-containing GRB2-like protein 1; SH3p8", "protein_names_refseq": "SH3 domain protein 2B; SH3 domain-containing GRB2-like protein 1; endophilin II; endophilin-2; endophilin-A2 isoform 1; endophilin-A2", "tax_id": 10090, "disease": "high grade glioma (Disease Ontology:DOID:3070); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (mmu:20405); (R-MMU-182971); (R-MMU-6807004); (R-MMU-8856825); (R-MMU-8856828)", "pathway_count": 5, "publication_count": 25, "publication_id_list": "15592455;19144319;19224205;20173027;21750661;22517741;22645316;23255596;26740625;28528544;29953872;30016717;30059200;31138815;32782141;33504785;34310897;34428180;34512174;35822049;36852467;37828378;40021952;40885482;9630982", "class_list": "", "function": "Endophilin A2 deficiency protects rodents from autoimmune arthritis by modulating T cell activation. Publication Status: Online-Only, [RefSeq, PubMed]; Endophilin A2-mediated alleviation of endoplasmic reticulum stress-induced cardiac injury involves the suppression of ERO1alpha/IP3R signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Endophilin-A2 is a critical mediator of endothelial cell migration and sprouting angiogenesis. ENDOA2 deficiency reduces VEGFR2 internalization and inhibits downstream activation of the signaling effector PAK but not ERK, thereby affecting front-rear polarity and migration but not proliferation or survival. Publication Status: Online-Only, [RefSeq, PubMed]; Implicated in endocytosis (PubMed:29953872). In a first step mediates neck formation during ultrafast endocytosis and function at a second step to aid in the removal of clathrin coats from the regenerated vesicles (PubMed:29953872). May recruit other proteins to membranes with high curvature (By similarity)., [UniProtKB, PubMed]; The variations of endophilin A2-FoxO3a-autophagy signal in angiotensin II-induced dopaminergic neuron injury mouse model and by biochanin A., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0044325 transmembrane transporter binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0045202 synapse", "go_biological_process": "GO:1900244 positive regulation of synaptic vesicle endocytosis;GO:0006897 endocytosis;GO:0098815 modulation of excitatory postsynaptic potential;GO:0061024 membrane organization;GO:0036465 synaptic vesicle recycling", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q62419-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C3Q5-1", "uniprot_id": [ { "id": "SHSA7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C3Q5", "type": "external" } ], "mass": 58334.0, "length": 558, "protein_name": "Protein shisa-7", "gene_name": "Shisa7", "organism": "Mouse", "refseq_name": "protein shisa-7 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001277220", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277220", "type": "external" } ], "gene_names_uniprotkb": "Shisa7", "gene_names_refseq": "Shisa7; ckamp59", "protein_names_uniprotkb": "Protein shisa-7; CKAMP59; Cystine-knot AMPAR modulating protein of 59 kDa; GABA(A) receptor auxiliary subunit Shisa7; Shisa family member 7", "protein_names_refseq": "GABA(A) receptor auxiliary subunit Shisa7; cysteine-knot AMPAR-modulating protein 59; cystine-knot AMPAR modulating protein of 59 kDa; protein shisa-7 isoform 2 precursor; protein shisa-7; shisa homolog 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:232813)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;16452087;21183079;21750661;26192747;26623514;29199957;30899004;31601770;33761345;35534528", "class_list": "", "function": "Activity- and sleep-dependent regulation of tonic inhibition by Shisa7., [RefSeq, PubMed]; Data indicate that Shisa7 regulates GABAAR trafficking, function, and pharmacology and reveal a previously unknown molecular interaction that modulates benzodiazepine action in the brain, [RefSeq, PubMed]; This study indicates that AMPAR function is very precisely controlled by the cell-type specific expression of the CKAMP family members 39, 52 and 59. Erratum:[Elife. 2018 Oct 11;7:e42543. doi: 10.7554/eLife.42543. PMID: 30306889] Publication Status: Online-Only, [RefSeq, PubMed]; Thus, Shisa7 is a bona-fide AMPA receptor modulatory protein affecting channel kinetics of the receptors, necessary for synaptic hippocampal plasticity, and memory recall. Erratum:[Elife. 2018 May 04;7:e36711. doi: 10.7554/eLife.36711. PMID: 29726811] Publication Status: Online-Only, [RefSeq, PubMed]; Transmembrane protein that regulates gamma-aminobutyric acid type A receptor (GABA(A)R) trafficking, channel deactivation kinetics and pharmacology, necessary for fast inhibitory transmission in the brain (PubMed:31601770). Enhances the action of benzodiazepine, a primary GABA(A)Rs target drug, in the brain (PubMed:31601770). May affect channel kinetics of AMPA-type glutamate receptors (AMPAR), the brain's main excitatory neurotransmitter, necessary for synaptic hippocampal plasticity, and memory recall (Probable). May regulate the induction and maintenance of long-term potentiation at Schaffer collaterals/CA3-CA1 excitatory synapses (Probable)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A0A172Q401;A0A172Q418;Q3UMB3", "ec_number_list": [], "go_molecular_function": "GO:0050811 GABA receptor binding;GO:0035255 ionotropic glutamate receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0014069 postsynaptic density;GO:0045211 postsynaptic membrane;GO:0032591 dendritic spine membrane;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0106040 regulation of GABA-A receptor activity;GO:0097112 gamma-aminobutyric acid receptor clustering;GO:1904717 regulation of AMPA glutamate receptor clustering;GO:0007613 memory;GO:1900273 positive regulation of long-term synaptic potentiation", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q8C3Q5-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.1100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q921I6-1", "uniprot_id": [ { "id": "SH3B4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q921I6", "type": "external" } ], "mass": 107584.0, "length": 962, "protein_name": "SH3 domain-binding protein 4", "gene_name": "Sh3bp4", "organism": "Mouse", "refseq_name": "SH3 domain-binding protein 4", "refseq_ac": [ { "id": "NP_598577", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598577", "type": "external" } ], "gene_names_uniprotkb": "Sh3bp4", "gene_names_refseq": "BOG25; Sh3bp4", "protein_names_uniprotkb": "SH3 domain-binding protein 4", "protein_names_refseq": "SH3 domain-binding protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:98402); (R-MMU-9639288)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;19122209;21183079;22575674;34203471;34428180", "class_list": "", "function": "May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy (By similarity)., [UniProtKB]; SH3BP4 is a negative regulator of the Rag GTPase complex and amino acid-dependent mTORC1 signaling, [RefSeq, PubMed]; TTP Ser(245) is the principal target for the modulation of this protein via the AKT signalling cascade., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BXV5;Q8BY95;Q8C007", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0031267 small GTPase binding;GO:0005092 GDP-dissociation inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005905 clathrin-coated pit;GO:0030136 clathrin-coated vesicle", "go_biological_process": "GO:0006897 endocytosis;GO:0008285 negative regulation of cell population proliferation;GO:0050790 regulation of catalytic activity;GO:0030308 negative regulation of cell growth;GO:0010508 positive regulation of autophagy", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q921I6-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21614-1", "uniprot_id": [ { "id": "VTDB_MOUSE", "url": "https://www.uniprot.org/uniprot/P21614", "type": "external" } ], "mass": 53600.0, "length": 476, "protein_name": "Vitamin D-binding protein", "gene_name": "Gc", "organism": "Mouse", "refseq_name": "vitamin D-binding protein precursor", "refseq_ac": [ { "id": "NP_032122", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032122", "type": "external" } ], "gene_names_uniprotkb": "Gc", "gene_names_refseq": "DBP; Gc; VDB", "protein_names_uniprotkb": "Vitamin D-binding protein; DBP; Gc-globulin; Group-specific component; VDB", "protein_names_refseq": "gc-globulin; group specific component; vitamin D-binding protein precursor", "tax_id": 10090, "disease": "primary progressive multiple sclerosis (Disease Ontology:DOID:0050784); pre-eclampsia (Disease Ontology:DOID:10591); sciatic neuropathy (Disease Ontology:DOID:11446); osteoporosis (Disease Ontology:DOID:11476); dengue disease (Disease Ontology:DOID:12205); Graves' disease (Disease Ontology:DOID:12361); neurodegenerative disease (Disease Ontology:DOID:1289); uveitis (Disease Ontology:DOID:13141); hepatic encephalopathy (Disease Ontology:DOID:13413); rheumatic fever (Disease Ontology:DOID:1586); brain ischemia (Disease Ontology:DOID:2316); multiple sclerosis (Disease Ontology:DOID:2377); asthma (Disease Ontology:DOID:2841); endometriosis (Disease Ontology:DOID:289); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); arthritis (Disease Ontology:DOID:848); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:14473); (R-MMU-196791)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;10052453;1696927;17330941;21750661;26495903;26740625;32152506;3243374;34428180;36445949;37453647;37507081;39627609;39927985", "class_list": "", "function": "GC-Globulin/Vitamin D-Binding Protein Is Required for Pancreatic alpha-Cell Adaptation to Metabolic Stress., [RefSeq, PubMed]; Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 24, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q7TS97;Q91XG1;Q9CY31", "ec_number_list": [], "go_molecular_function": "GO:0090482 vitamin transmembrane transporter activity;GO:0003779 actin binding;GO:0005499 vitamin D binding;GO:1902118 calcidiol binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0030424 axon;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0042359 vitamin D metabolic process;GO:0031667 response to nutrient levels", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P21614-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PEV3-1", "uniprot_id": [ { "id": "WIPF2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PEV3", "type": "external" } ], "mass": 46297.0, "length": 440, "protein_name": "WAS/WASL-interacting protein family member 2", "gene_name": "Wipf2", "organism": "Mouse", "refseq_name": "WAS/WASL-interacting protein family member 2", "refseq_ac": [ { "id": "NP_922922", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_922922", "type": "external" } ], "gene_names_uniprotkb": "Wipf2; Wire", "gene_names_refseq": "1110014J05Rik; 5730509C05Rik; Gm1176; Wich; Wipf2; Wire", "protein_names_uniprotkb": "WAS/WASL-interacting protein family member 2; WASP-interacting protein-related protein; WIP-related protein", "protein_names_refseq": "WAS/WASL-interacting protein family member 2; WASP-binding protein; WASP-interacting protein-related protein; WIP-related protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:68524)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;24129315;26192747;32782141;34428180", "class_list": "", "function": "Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q6PEV3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27870-1", "uniprot_id": [ { "id": "VAV_MOUSE", "url": "https://www.uniprot.org/uniprot/P27870", "type": "external" } ], "mass": 98137.0, "length": 845, "protein_name": "Proto-oncogene vav", "gene_name": "Vav1", "organism": "Mouse", "refseq_name": "proto-oncogene vav isoform 1", "refseq_ac": [ { "id": "NP_035821", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035821", "type": "external" } ], "gene_names_uniprotkb": "Vav1; Vav", "gene_names_refseq": "Vav1; Vav; vav-T", "protein_names_uniprotkb": "Proto-oncogene vav; p95vav", "protein_names_refseq": "p95vav; proto-oncogene vav isoform 1; proto-oncogene vav; vav 1 oncogene; vav oncogene", "tax_id": 10090, "disease": "endometriosis (Disease Ontology:DOID:289); lymphopenia (Disease Ontology:DOID:614); hepatocellular carcinoma (Disease Ontology:DOID:684); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:22324); (R-MMU-114604); (R-MMU-1257604); (R-MMU-1433557); (R-MMU-193648); (R-MMU-2029482); (R-MMU-2871796); (R-MMU-2871809); (R-MMU-389359); (R-MMU-416482); (R-MMU-4420097); (R-MMU-512988); (R-MMU-5218920); (R-MMU-6811558); (R-MMU-8980692); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013408); (R-MMU-9027284); (R-MMU-912631); (R-MMU-9748787); (R-MMU-983695)", "pathway_count": 22, "publication_count": 22, "publication_id_list": "10521418;10646608;10646609;10662792;11463797;1565462;17000758;17947660;19064729;19577230;2005887;20644716;2069873;21750661;24584089;34428180;35752351;35895495;38565808;39627609;8877094;9400828", "class_list": "", "function": "Characterization of the spectrum of trivalent VAV1-mutation-driven tumours using a gene-edited mouse model., [RefSeq, PubMed]; Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation., [UniProtKB]; Positive regulation of Vav1 by Themis controls CD4 T cell pathogenicity in a mouse model of central nervous system inflammation. Publication Status: Online-Only, [RefSeq, PubMed]; Vav1 accelerates Ras-driven lung cancer and modulates its tumor microenvironment., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BTV7", "ec_number_list": [], "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0008270 zinc ion binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0140031 phosphorylation-dependent protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005911 cell-cell junction", "go_biological_process": "GO:0006955 immune response;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007229 integrin-mediated signaling pathway;GO:0016477 cell migration;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P27870-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47810-1", "uniprot_id": [ { "id": "WEE1_MOUSE", "url": "https://www.uniprot.org/uniprot/P47810", "type": "external" } ], "mass": 71578.0, "length": 646, "protein_name": "Wee1-like protein kinase", "gene_name": "Wee1", "organism": "Mouse", "refseq_name": "wee1-like protein kinase isoform 1", "refseq_ac": [ { "id": "NP_033542", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033542", "type": "external" } ], "gene_names_uniprotkb": "Wee1", "gene_names_refseq": "Wee1A; Wee1", "protein_names_uniprotkb": "Wee1-like protein kinase; 2.7.10.2; Wee1A kinase", "protein_names_refseq": "WEE1 tyrosine kinase; wee1-like protein kinase isoform 1; wee1-like protein kinase; wee1A kinase", "tax_id": 10090, "disease": "", "pathway": " (mmu:22390); (R-MMU-156711); (R-MMU-69202); (R-MMU-69273); (R-MMU-69478); (R-MMU-69656); (R-MMU-75035)", "pathway_count": 7, "publication_count": 10, "publication_id_list": "11528126;21183079;31219806;34428180;37549603;38874119;38992067;39407201;7551544;9016762", "class_list": "", "function": "Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation., [UniProtKB, UniProtKB]; Androgen blockage impairs proliferation and function of Sertoli cells via Wee1 and Lfng. Publication Status: Online-Only, [RefSeq, PubMed]; Autophagy modulates the stability of Wee1 and cell cycle G2/M transition., [RefSeq, PubMed]; Hyperactivation of p53 contributes to mitotic catastrophe in podocytes through regulation of the Wee1/CDK1/cyclin B1 axis., [RefSeq, PubMed]; Synergistic induction of mitotic pyroptosis and tumor remission by inhibiting proteasome and WEE family kinases. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9EPL7", "ec_number_list": [ { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004672 protein kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007077 mitotic nuclear membrane disassembly;GO:0010971 positive regulation of G2/M transition of mitotic cell cycle;GO:0018108 peptidyl-tyrosine phosphorylation;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P47810-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6GQR8-1", "uniprot_id": [ { "id": "ZN329_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6GQR8", "type": "external" } ], "mass": 59832.0, "length": 522, "protein_name": "Zinc finger protein 329", "gene_name": "Zfp329; Znf329", "organism": "Mouse", "refseq_name": "zinc finger protein 329", "refseq_ac": [ { "id": "NP_080322", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080322", "type": "external" } ], "gene_names_uniprotkb": "Zfp329; Znf329; Zfp329", "gene_names_refseq": "2810439M05Rik; 4632409L22Rik; ZNF329; Zfp329", "protein_names_uniprotkb": "Zinc finger protein 329", "protein_names_refseq": "zinc finger protein 329", "tax_id": 10090, "disease": "", "pathway": " (mmu:67230)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21183079;21750661", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BKL5;Q9D459", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0009891 positive regulation of biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6GQR8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q6W4-1", "uniprot_id": [ { "id": "ZN296_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q6W4", "type": "external" } ], "mass": 47821.0, "length": 445, "protein_name": "Zinc finger protein 296", "gene_name": "Znf296", "organism": "Mouse", "refseq_name": "zinc finger protein 296", "refseq_ac": [ { "id": "NP_071854", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071854", "type": "external" } ], "gene_names_uniprotkb": "Znf296; Zfp296", "gene_names_refseq": "2210018A16Rik; Zfp296; Znf296", "protein_names_uniprotkb": "Zinc finger protein 296; Hepatocellular carcinoma-associated antigen MHCA108", "protein_names_refseq": "hepatocellular carcinoma-associated antigen MHCA108; zinc finger protein 296", "tax_id": 10090, "disease": "", "pathway": " (mmu:63872)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11063263;24161396;37488353;38334180", "class_list": "", "function": "May be a transcriptional corepressor with KLF4., [UniProtKB, PubMed]; The stem cell transcription factor ZFP296 transforms NIH3T3 cells and promotes anchorage-independent growth of cancer cells., [RefSeq, PubMed]; Zfp296 knockout enhances chromatin accessibility and induces a unique state of pluripotency in embryonic stem cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4FZI6;Q9D7X0;Q9EPM0", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:2000171 negative regulation of dendrite development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "E9Q6W4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61527-1", "uniprot_id": [ { "id": "ERBB4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61527", "type": "external" } ], "mass": 146855.0, "length": 1308, "protein_name": "Receptor tyrosine-protein kinase erbB-4", "gene_name": "Erbb4", "organism": "Mouse", "refseq_name": "receptor tyrosine-protein kinase erbB-4 precursor", "refseq_ac": [ { "id": "NP_034284", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034284", "type": "external" } ], "gene_names_uniprotkb": "Erbb4; Mer4", "gene_names_refseq": "Erbb4; Her4; c-erbB-4", "protein_names_uniprotkb": "Receptor tyrosine-protein kinase erbB-4; 2.7.10.1; Proto-oncogene-like protein c-ErbB-4; s80HER4", "protein_names_refseq": "avian erythroblastosis oncogene B 4; proto-oncogene-like protein c-ErbB-4; receptor tyrosine-protein kinase erbB-4 precursor; receptor tyrosine-protein kinase erbB-4; v-erb-a erythroblastic leukemia viral oncogene homolog 4", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); stroke (Disease Ontology:DOID:0051061); ductal carcinoma in situ (Disease Ontology:DOID:0060074); amyotrophic lateral sclerosis type 19 (Disease Ontology:DOID:0060210); intestinal cancer (Disease Ontology:DOID:10155); prostate cancer (Disease Ontology:DOID:10283); amblyopia (Disease Ontology:DOID:10376); urinary bladder cancer (Disease Ontology:DOID:11054); interstitial cystitis (Disease Ontology:DOID:13949); alcohol use disorder (Disease Ontology:DOID:1574); cancer (Disease Ontology:DOID:162); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); transitional cell carcinoma (Disease Ontology:DOID:2671); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); carcinoma (Disease Ontology:DOID:305); bipolar disorder (Disease Ontology:DOID:3312); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung adenocarcinoma (Disease Ontology:DOID:3910); radiculopathy (Disease Ontology:DOID:4306); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450); schizophrenia (Disease Ontology:DOID:5419); stomach carcinoma (Disease Ontology:DOID:5517); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); median neuropathy (Disease Ontology:DOID:571); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:13869); (R-MMU-1227986); (R-MMU-1236394); (R-MMU-1250196); (R-MMU-1250342); (R-MMU-1250347); (R-MMU-1251985); (R-MMU-1253288); (R-MMU-1257604); (R-MMU-1963640); (R-MMU-1963642); (R-MMU-5673001); (R-MMU-6785631); (R-MMU-6811558); (R-MMU-8847993); (R-MMU-8863795); (R-MMU-9018519)", "pathway_count": 17, "publication_count": 24, "publication_id_list": "10.1101/2023.09.13.557529;10353604;10508857;10655590;12824469;12954715;14504474;15543145;15863494;16815842;16837552;19596786;19632177;21295966;21750661;24142862;26745281;28743784;29636063;30899004;34428180;7477376;7589796;9334263", "class_list": "", "function": "Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 5, "disease_count": 32, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "B2KGF5;B2KGF6;O88460;Q3UNS6", "ec_number_list": [ { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.4.23.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.-", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" } ], "go_molecular_function": "GO:0038131 neuregulin receptor activity;GO:0038132 neuregulin binding;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005886 plasma membrane", "go_biological_process": "GO:0021551 central nervous system morphogenesis;GO:0061026 cardiac muscle tissue regeneration;GO:0072046 establishment of planar polarity involved in nephron morphogenesis;GO:0006351 DNA-templated transcription;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "Q61527-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1W617-1", "uniprot_id": [ { "id": "SHRM4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q1W617", "type": "external" } ], "mass": 163238.0, "length": 1475, "protein_name": "Protein Shroom4", "gene_name": "Shroom4", "organism": "Mouse", "refseq_name": "protein Shroom4 isoform 1", "refseq_ac": [ { "id": "NP_001035549", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035549", "type": "external" } ], "gene_names_uniprotkb": "Shroom4; Kiaa1202", "gene_names_refseq": "D430043L16Rik; Gm724; Shrm4; Shroom4", "protein_names_uniprotkb": "Protein Shroom4", "protein_names_refseq": "protein Shroom4 isoform 1; protein Shroom4", "tax_id": 10090, "disease": "", "pathway": " (mmu:208431)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "16249884;16615870;17009331;21183079;21750661;31654185;34418053;36379543;40885482", "class_list": "", "function": "Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II., [UniProtKB, PubMed]; The overexpression of Shrm4 or activation of GABAB1 upregulated the levels of Shrm4, GABAB1, Bcl-2, MAP-2 and SOCS2, while downregulated Bax and cleaved Caspase-3 in NSCs. Overall, overexpression of Shrm4 activated GABAB1 to stimulate the proliferation and differentiation of NSCs. Erratum:[Mol Cell Biochem. 2020 Sep;472(1-2):255-257. doi: 10.1007/s11010-020-03786-8. PMID: 32583147], [RefSeq, PubMed]; X-linked variations in SHROOM4 are implicated in congenital anomalies of the urinary tract and the anorectal, cardiovascular and central nervous systems., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2ADV9;B2RX74;Q69ZN9", "ec_number_list": [], "go_molecular_function": "GO:0045159 myosin II binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005884 actin filament", "go_biological_process": "GO:0007015 actin filament organization;GO:0050890 cognition;GO:0007420 brain development;GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q1W617-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3THJ3-1", "uniprot_id": [ { "id": "EIF1A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3THJ3", "type": "external" } ], "mass": 19520.0, "length": 170, "protein_name": "Probable RNA-binding protein EIF1AD", "gene_name": "Eif1ad", "organism": "Mouse", "refseq_name": "probable RNA-binding protein EIF1AD", "refseq_ac": [ { "id": "NP_081512", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081512", "type": "external" } ], "gene_names_uniprotkb": "Eif1ad", "gene_names_refseq": "2010003J03Rik; Eif1ad1; Eif1ad", "protein_names_uniprotkb": "Probable RNA-binding protein EIF1AD; Eukaryotic translation initiation factor 1A domain-containing protein", "protein_names_refseq": "eukaryotic translation initiation factor 1A domain-containing protein; probable RNA-binding protein EIF1AD", "tax_id": 10090, "disease": "", "pathway": " (mmu:69860)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21183079", "class_list": "", "function": "Plays a role into cellular response to oxidative stress. Decreases cell proliferation (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K1C2;Q9D8F9", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3THJ3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61211-1", "uniprot_id": [ { "id": "EIF2D_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61211", "type": "external" } ], "mass": 62830.0, "length": 570, "protein_name": "Eukaryotic translation initiation factor 2D", "gene_name": "Eif2d", "organism": "Mouse", "refseq_name": "eukaryotic translation initiation factor 2D isoform 1", "refseq_ac": [ { "id": "NP_001129542", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129542", "type": "external" } ], "gene_names_uniprotkb": "Eif2d; Lgtn", "gene_names_refseq": "D1Ertd5e; Eif2d; Lgtn", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 2D; Ligatin; eIF2D", "protein_names_refseq": "eukaryotic translation initiation factor 2D isoform 1; ligatin", "tax_id": 10090, "disease": "", "pathway": " (mmu:16865)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21183079;21750661;31219806;34428180;35820727;9070942", "class_list": "", "function": "Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TDE0;Q3THV5;Q3TTP4;Q8C491;Q8CBF1;Q8CC17;Q8R1I9;Q8R3M5", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016604 nuclear body", "go_biological_process": "GO:0032790 ribosome disassembly;GO:0075522 IRES-dependent viral translational initiation;GO:0001731 formation of translation preinitiation complex", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q61211-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q69ZW3-1", "uniprot_id": [ { "id": "EHBP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q69ZW3", "type": "external" } ], "mass": 139104.0, "length": 1231, "protein_name": "EH domain-binding protein 1", "gene_name": "Ehbp1", "organism": "Mouse", "refseq_name": "EH domain-binding protein 1 isoform 1", "refseq_ac": [ { "id": "NP_001239444", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239444", "type": "external" } ], "gene_names_uniprotkb": "Ehbp1; Kiaa0903", "gene_names_refseq": "Ehbp1; Flj21950; NACSIN", "protein_names_uniprotkb": "EH domain-binding protein 1", "protein_names_refseq": "DNA sequence AF424697; EH domain-binding protein 1 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:216565)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;12174196;14676205;15247266;15345747;21183079;21750661;34203471", "class_list": "", "function": "EHBP1 is an EH domain binding protein that, along with EHD2, has a role in coupling endocytosis to the actin cytoskeleton [EHBP1], [RefSeq, PubMed]; EHD1 and EHBP1, but not EHD2, are required for perinuclear localization of GLUT4 and reveal that loss of EHBP1 disrupts insulin-regulated GLUT4 recycling in cultured adipocytes., [RefSeq, PubMed]; May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (By similarity). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9718, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QMJ9;Q5SQK3;Q91ZJ6", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005768 endosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0015031 protein transport;GO:0030036 actin cytoskeleton organization;GO:0032456 endocytic recycling", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q69ZW3-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6X7S9-1", "uniprot_id": [ { "id": "EID2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6X7S9", "type": "external" } ], "mass": 25304.0, "length": 236, "protein_name": "EP300-interacting inhibitor of differentiation 2", "gene_name": "Eid2", "organism": "Mouse", "refseq_name": "EP300-interacting inhibitor of differentiation 2", "refseq_ac": [ { "id": "NP_940817", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_940817", "type": "external" } ], "gene_names_uniprotkb": "Eid2; Cri2", "gene_names_refseq": "Cri2; EID-2; Eid2", "protein_names_uniprotkb": "EP300-interacting inhibitor of differentiation 2; CREBBP/EP300 inhibitor 2; EID-1-like inhibitor of differentiation 2; EID-2", "protein_names_refseq": "CREBBP/EP300 inhibitor 2; CREBBP/EP300 inhibitory protein 2; E1A like inhibitor of differentiation 2; EID-1-like inhibitor of differentiation 2; EP300-interacting inhibitor of differentiation 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:386655)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "14585496;15970276;24129315", "class_list": "", "function": "Interacts with EP300 and acts as a repressor of MYOD-dependent transcription and muscle differentiation. Inhibits EP300 histone acetyltransferase activity. Acts as a repressor of TGFB/SMAD transcriptional responses. May act as a repressor of the TGFB/SMAD3-dependent signaling by selectively blocking formation of TGFB-induced SMAD3-SMAD4 complex (By similarity)., [UniProtKB, UniProtKB]; Unlike that of EID-2, the C-terminus, but not the N-terminus, of EID-3 was required for nuclear localization. EID-3 formed a homodimer or heterodimer with EID-2, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003714 transcription corepressor activity;GO:0046332 SMAD binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0042127 regulation of cell population proliferation;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6X7S9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BMS1-1", "uniprot_id": [ { "id": "ECHA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BMS1", "type": "external" } ], "mass": 82670.0, "length": 763, "protein_name": "Trifunctional enzyme subunit alpha, mitochondrial", "gene_name": "Hadha", "organism": "Mouse", "refseq_name": "trifunctional enzyme subunit alpha, mitochondrial precursor", "refseq_ac": [ { "id": "NP_849209", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_849209", "type": "external" } ], "gene_names_uniprotkb": "Hadha", "gene_names_refseq": "Hadha; MLCL AT; Mtpa; TP-alpha", "protein_names_uniprotkb": "Trifunctional enzyme subunit alpha, mitochondrial; 2.3.1.-; MLCL AT; Monolysocardiolipin acyltransferase; TP-alpha", "protein_names_refseq": "hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit; monolysocardiolipin acyltransferase; trifunctional enzyme subunit alpha, mitochondrial precursor; trifunctional enzyme subunit alpha, mitochondrial", "tax_id": 10090, "disease": "long chain 3-hydroxyacyl-CoA dehydrogenase deficiency (Disease Ontology:DOID:0061186); mitochondrial trifunctional protein deficiency 1 (Disease Ontology:DOID:0070619); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Alzheimer's disease (Disease Ontology:DOID:10652); lipid metabolism disorder (Disease Ontology:DOID:3146); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (mmu:97212); (R-MMU-1482798); (R-MMU-77285); (R-MMU-77305); (R-MMU-77310); (R-MMU-77346); (R-MMU-77348); (R-MMU-77350)", "pathway_count": 8, "publication_count": 21, "publication_id_list": "15887119;16916647;21183079;23576753;23806337;24129315;29187734;29949755;30084848;31219806;31599954;33300544;34428180;35820727;36064721;36288343;37453647;37507081;37843279;39627609;39927985", "class_list": "", "function": "Heterozygosity for beta-oxidation defects predisposes to fatty live disease and insulin resistance in aging mice, [RefSeq, PubMed]; Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through cycles of four consecutive reactions. Each beta-oxidation cycle shortens the fatty acyl-CoA by two carbons, yielding one acetyl-CoA (for the citric acid cycle), one FADH(2), and one NADH (which donate electrons to the respiratory chain for ATP production). These cycles repeat until the chain is fully degraded to acetyl-CoA units. Among the enzymes involved in this pathway, the trifunctional protein--responsible for the hydration, dehydrogenation, and thiolysis steps, shows specificity for long-chain fatty acids, such as those from dietary and stored fats. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enzyme subunit alpha/HADHA described here carries the 2,3-enoyl-CoA hydratase and the 3-hydroxyacyl-CoA dehydrogenase activities while the trifunctional enzyme subunit beta/HADHB bears the 3-ketoacyl-CoA thiolase activity. These activities have been experimentally confirmed on a few substrates derived from beta-oxidation of long-chain saturated fatty acids such as palmitate (hexadecanoate) and laurate (dodecanoate). In addition, based on its established catalytic mechanism, and combined genetic interaction or mutant phenotype evidence, it is predicted to act also on other substrates, including long-chain unsaturated fatty acids such as oleate (9Z-octadecenoate), linoleate (9Z,12Z-octadecadienoate), linolenate (9Z,12Z,15Z-octadecatrienoate), and others. Independently of subunit beta, HADHA also exhibits a cardiolipin acyltransferase activity that participates in cardiolipin remodeling; cardiolipin is a major mitochondrial membrane phospholipid. HADHA may act downstream of Tafazzin/TAZ, that remodels monolysocardiolipin (MLCL) to a cardiolipin intermediate, and then HADHA may continue to remodel this species into mature tetralinoleoyl-cardiolipin. Has also been proposed to act directly on MLCL; capable of acylating MLCL using different acyl-CoA substrates, with highest activity for oleoyl-CoA., [UniProtKB, UniProtKB]; Zfp335 establishes eTreg lineage and neonatal immune tolerance by targeting Hadha-mediated fatty acid oxidation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TCY3;Q5U5Y5;Q8QZU4", "ec_number_list": [ { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "4.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.17", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "1.1.1.211", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.211", "type": "external" } ], "go_molecular_function": "GO:0016509 long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity;GO:0051287 NAD binding;GO:0044877 protein-containing complex binding;GO:0000062 fatty-acyl-CoA binding;GO:0070403 NAD+ binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0042645 mitochondrial nucleoid;GO:0016507 mitochondrial fatty acid beta-oxidation multienzyme complex", "go_biological_process": "GO:0006635 fatty acid beta-oxidation;GO:0032868 response to insulin;GO:0035965 cardiolipin acyl-chain remodeling;GO:0009410 response to xenobiotic stimulus", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q8BMS1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D4J1-1", "uniprot_id": [ { "id": "EFHD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D4J1", "type": "external" } ], "mass": 27000.0, "length": 240, "protein_name": "EF-hand domain-containing protein D1", "gene_name": "Efhd1", "organism": "Mouse", "refseq_name": "EF-hand domain-containing protein D1", "refseq_ac": [ { "id": "NP_083165", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083165", "type": "external" } ], "gene_names_uniprotkb": "Efhd1; Sws2", "gene_names_refseq": "4931430I01Rik; Efhd1; PP3051; mitocalcin", "protein_names_uniprotkb": "EF-hand domain-containing protein D1; EF-hand domain-containing protein 1; Mitocalcin; Swiprosin-2", "protein_names_refseq": "EF-hand domain-containing protein 1; EF-hand domain-containing protein D1; swiprosin-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:98363)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12270117;16336229;28524857;32414840;34428180;37507081", "class_list": "", "function": "Acts as a calcium sensor for mitochondrial flash (mitoflash) activation, an event characterized by stochastic bursts of superoxide production (By similarity). May play a role in neuronal differentiation (PubMed:16336229)., [UniProtKB, PubMed, UniProtKB]; Coordinated expression of EFhd1 in pro B cells and by the pre BCR regulates metabolic changes and pro/pre B-cell development., [RefSeq, PubMed]; Regulation of axonal morphogenesis by the mitochondrial protein Efhd1. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q543U4", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0061891 calcium ion sensor activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0031175 neuron projection development;GO:1900069 regulation of cellular hyperosmotic salinity response", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9D4J1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DCR4-1", "uniprot_id": [ { "id": "EID1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DCR4", "type": "external" } ], "mass": 18921.0, "length": 169, "protein_name": "EP300-interacting inhibitor of differentiation 1", "gene_name": "Eid1", "organism": "Mouse", "refseq_name": "EP300-interacting inhibitor of differentiation 1", "refseq_ac": [ { "id": "NP_079889", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079889", "type": "external" } ], "gene_names_uniprotkb": "Eid1; Cri1", "gene_names_refseq": "2610002K20Rik; Cri1; EID-1; Eid1; ORF12; PNAS-22; PTD014", "protein_names_uniprotkb": "EP300-interacting inhibitor of differentiation 1; CREBBP/EP300 inhibitory protein 1; E1A-like inhibitor of differentiation 1; EID-1", "protein_names_refseq": "CREBBP/EP300 inhibitory protein 1; E1A-like inhibitor of differentiation 1; EP300-interacting inhibitor of differentiation 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:58521)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11964378;18182853;26497028;30926163;31381951;32056205", "class_list": "", "function": "EID-1 is expressed in the mouse testis, and its expression decreases during testis development. The results of the present study suggest that EID-1 can act as a repressor, regulating the function of SF-1., [RefSeq, PubMed]; EID1 suppresses lipid accumulation by inhibiting the expression of GPDH in 3T3-L1 preadipocytes., [RefSeq, PubMed]; Eid1 knockout impeded the proliferation of neural stem cells., [RefSeq, PubMed]; Interacts with RB1 and EP300 and acts as a repressor of MYOD1 transactivation. Inhibits EP300 and CBP histone acetyltransferase activity. May be involved in coupling cell cycle exit to the transcriptional activation of genes required for cellular differentiation. May act as a candidate coinhibitory factor for NR0B2 that can be directly linked to transcription inhibitory mechanisms., [UniProtKB, PubMed]; Isolation of mouse E1A-like inhibitor of differentiation 1 (EID1) as a candidate coinhibitor for SHP, [RefSeq, PubMed]; Palmitoylation modified E1A-like inhibitor of differentiation one (EID1) and this modification regulated EID1 degradation and CREB-binding protein (CBP)/p300 histone acetyltransferase activity at the switch between self-renewal and differentiation of neural stem cells., [RefSeq, PubMed]; Regulation of cell proliferation is the main functions of Eid1 in mice brain., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T9D1;Q8BP25;Q9CQ17;Q9CYM0", "ec_number_list": [], "go_molecular_function": "GO:0003714 transcription corepressor activity;GO:0035035 histone acetyltransferase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0036464 cytoplasmic ribonucleoprotein granule", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9DCR4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32020-1", "uniprot_id": [ { "id": "SCP2_MOUSE", "url": "https://www.uniprot.org/uniprot/P32020", "type": "external" } ], "mass": 59126.0, "length": 547, "protein_name": "Sterol carrier protein 2", "gene_name": "Scp2", "organism": "Mouse", "refseq_name": "sterol carrier protein 2", "refseq_ac": [ { "id": "NP_035457", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035457", "type": "external" } ], "gene_names_uniprotkb": "Scp2; Scp-2", "gene_names_refseq": "NSL-TP; SCP-2; SCP-X; SCPX; Scp2; ns-LTP", "protein_names_uniprotkb": "Sterol carrier protein 2; 2.3.1.155; 2.3.1.16; 2.3.1.176; Acetyl-CoA C-myristoyltransferase; NSL-TP; Non-specific lipid-transfer protein; Propanoyl-CoA C-acyltransferase; SCP-2/3-oxoacyl-CoA thiolase; SCP-2/thiolase; SCP-2; SCP-X; SCP-chi; Sterol carrier protein X", "protein_names_refseq": "SCP-2/3-oxoacyl-CoA thiolase; SCP-2/thiolase; SCP-chi; acetyl-CoA C-myristoyltransferase; non-specific lipid-transfer protein; nonspecific lipid transfer protein; propanoyl-CoA C-acyltransferase; sterol carrier protein 2; sterol carrier protein X; straight-chain acyl-CoA oxidase", "tax_id": 10090, "disease": "Zellweger syndrome (Disease Ontology:DOID:905); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:20280); (R-MMU-193368); (R-MMU-2046106); (R-MMU-389887); (R-MMU-9033241)", "pathway_count": 5, "publication_count": 19, "publication_id_list": "10706581;11003606;16916647;1709640;17208939;17242355;21750661;23576753;23806337;26901662;29700117;29763591;31487051;34428180;37453647;37507081;8428655;8751375;9553048", "class_list": "", "function": "Both FABP1 and SCP-2 participate in regulating the Brain endocannabinoids (EC) system in the brain., [RefSeq, PubMed]; Mediates the transfer of all common phospholipids, cholesterol and gangliosides from the endoplasmic reticulum to the plasma membrane. May play a role in regulating steroidogenesis (By similarity). Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol (By similarity). Also binds fatty acids and fatty acyl Coenzyme A (CoA) such as phytanoyl-CoA (PubMed:9553048). Involved in the regulation phospholipid synthesis in endoplasmic reticulum enhancing the incorporation of exogenous fatty acid into glycerides (PubMed:11003606). Seems to stimulate the rate-limiting step in phosphatidic acid formation mediated by GPAT3 (PubMed:11003606). Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs (PubMed:9553048)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]; Plays a crucial role in the peroxisomal oxidation of branched-chain fatty acids (PubMed:10706581). Catalyzes the last step of the peroxisomal beta-oxidation of branched chain fatty acids and the side chain of the bile acid intermediates di- and trihydroxycoprostanic acids (DHCA and THCA) (PubMed:10706581). Also active with medium and long straight chain 3-oxoacyl-CoAs (By similarity). Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol and transfers phosphatidylcholine and 7-dehydrocholesterol between membrances, in vitro (By similarity). Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs (PubMed:9553048)., [UniProtKB, UniProtKB, PubMed, PubMed]; These findings suggested that ablation of the Scp-2/Scp-x gene in Fabp1 null mice exacerbated hepatic endocannabinoid (EC) accumulation and antagonized the impact of high fat diet on hepatic EC levels-suggesting both proteins play important roles in regulating the hepatic EC system., [RefSeq, PubMed]; These results indicate an important regulatory role for SCP2 deficiency in attenuating diet-induced atherosclerosis by limiting intestinal cholesterol absorption and decreasing hepatic triglyceride/VLDL secretion., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2APS2;A2APS3;Q9DBM7", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.1.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4", "type": "external" }, { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "1.5.3.13", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.13", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "1.4.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1", "type": "external" }, { "id": "4.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.9", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "1.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.1", "type": "external" }, { "id": "1.5.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.7", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "1.2.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" } ], "go_molecular_function": "GO:0033814 propanoyl-CoA C-acyltransferase activity;GO:0050632 propionyl-CoA C2-trimethyltridecanoyltransferase activity;GO:0070538 oleic acid binding;GO:0005102 signaling receptor binding;GO:0005504 fatty acid binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005782 peroxisomal matrix", "go_biological_process": "GO:0032385 positive regulation of intracellular cholesterol transport;GO:0032959 inositol trisphosphate biosynthetic process;GO:0045940 positive regulation of steroid metabolic process;GO:1901373 lipid hydroperoxide transport;GO:0071926 endocannabinoid signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P32020-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35436-1", "uniprot_id": [ { "id": "NMDE1_MOUSE", "url": "https://www.uniprot.org/uniprot/P35436", "type": "external" } ], "mass": 165421.0, "length": 1464, "protein_name": "Glutamate receptor ionotropic, NMDA 2A", "gene_name": "Grin2a", "organism": "Mouse", "refseq_name": "glutamate receptor ionotropic, NMDA 2A precursor", "refseq_ac": [ { "id": "NP_032196", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032196", "type": "external" } ], "gene_names_uniprotkb": "Grin2a", "gene_names_refseq": "GluN2A; GluRepsilon1; Grin2a; NMDAR2A; NR2A", "protein_names_uniprotkb": "Glutamate receptor ionotropic, NMDA 2A; GluN2A; Glutamate [NMDA] receptor subunit epsilon-1; N-methyl D-aspartate receptor subtype 2A; NMDAR2A; NR2A", "protein_names_refseq": "N-methyl D-aspartate receptor subtype 2A; glutamate [NMDA] receptor subunit epsilon-1; glutamate receptor ionotropic, NMDA 2A precursor; glutamate receptor ionotropic, NMDA 2A", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); withdrawal disorder (Disease Ontology:DOID:0060001); developmental disorder of mental health (Disease Ontology:DOID:0060037); Alzheimer's disease (Disease Ontology:DOID:10652); opioid abuse (Disease Ontology:DOID:11206); Huntington's disease (Disease Ontology:DOID:12858); cognitive disorder (Disease Ontology:DOID:1561); alcohol use disorder (Disease Ontology:DOID:1574); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); post-traumatic stress disorder (Disease Ontology:DOID:2055); transient cerebral ischemia (Disease Ontology:DOID:224); bipolar disorder (Disease Ontology:DOID:3312); placental insufficiency (Disease Ontology:DOID:3891); schizophrenia (Disease Ontology:DOID:5419); vascular dementia (Disease Ontology:DOID:8725); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261); hyperhomocysteinemia (Disease Ontology:DOID:9279); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:14811); (R-MMU-438066); (R-MMU-8849932); (R-MMU-9609736)", "pathway_count": 4, "publication_count": 23, "publication_id_list": "10.1101/2023.09.13.557529;10436042;12008020;1374164;17114649;17329427;18322192;19243221;21183079;23524343;25301084;25368549;25645137;28649199;29754475;30899004;31196628;33158444;35820727;40885482;7790891;7816096;8987814", "class_list": "", "function": "Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:12008020, PubMed:1374164). NMDARs participate in synaptic plasticity for learning and memory formation by contributing to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (PubMed:7816096, PubMed:8987814). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:12008020, PubMed:1374164, PubMed:7790891). NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium (By similarity). Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (PubMed:10436042, PubMed:12008020). Participates in the synaptic plasticity regulation through activation by the L-glutamate releaseed by BEST1, into the synaptic cleft, upon F2R/PAR-1 activation in astrocyte (PubMed:25645137)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 9, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 10, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 10, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 9, "disease_count": 20, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0022849 glutamate-gated calcium ion channel activity;GO:0005102 signaling receptor binding;GO:0005262 calcium channel activity;GO:0008270 zinc ion binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0017146 NMDA selective glutamate receptor complex;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "GO:0001964 startle response;GO:1903539 protein localization to postsynaptic membrane;GO:0007611 learning or memory;GO:0007612 learning;GO:0007613 memory", "synthesized_glycan_count": 0, "hit_score": 4.4, "record_id": "P35436-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49117-1", "uniprot_id": [ { "id": "NR2C2_MOUSE", "url": "https://www.uniprot.org/uniprot/P49117", "type": "external" } ], "mass": 65239.0, "length": 596, "protein_name": "Nuclear receptor subfamily 2 group C member 2", "gene_name": "Nr2c2", "organism": "Mouse", "refseq_name": "nuclear receptor subfamily 2 group C member 2 isoform 1", "refseq_ac": [ { "id": "NP_001334271", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334271", "type": "external" } ], "gene_names_uniprotkb": "Nr2c2; Mtr2r1; Tak1; Tr4", "gene_names_refseq": "Nr2c2; TAK1; Tr4; mKIAA4145", "protein_names_uniprotkb": "Nuclear receptor subfamily 2 group C member 2; Orphan nuclear receptor TAK1; Orphan nuclear receptor TR4; Testicular receptor 4", "protein_names_refseq": "nuclear receptor subfamily 2 group C member 2 isoform 1; nuclear receptor subfamily 2, group H, member 2; orphan nuclear receptor TAK1; orphan nuclear receptor TR4; orphan receptor, TR4; testicular receptor 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:22026); (R-MMU-383280); (R-MMU-9940951)", "pathway_count": 3, "publication_count": 21, "publication_id_list": "10.1101/2023.09.13.557529;10347174;12093744;15199144;16887930;17706948;17974920;19131575;20393820;21478464;21750661;23806337;30084848;34428180;35820727;37832545;38429762;38729452;38773142;7590273;7841789", "class_list": "", "function": "Disruption of TIGAR-TAK1 alleviates immunopathology in a murine model of sepsis. Publication Status: Online-Only, [RefSeq, PubMed]; Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Activates transcriptional activity of LHCG and is antagonist of PPARA-mediated transactivation (By similarity). Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Roquin-2 promotes oxidative stress-induced cell death by ubiquitination-dependent degradation of TAK1., [RefSeq, PubMed]; TAK1 is an essential kinase for STING trafficking., [RefSeq, PubMed]; TR4 worsen urosepsis by regulating GSDMD. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9768, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P55093", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016605 PML body", "go_biological_process": "GO:0048520 positive regulation of behavior;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P49117-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6GQT9-1", "uniprot_id": [ { "id": "NOMO1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6GQT9", "type": "external" } ], "mass": 133420.0, "length": 1214, "protein_name": "BOS complex subunit NOMO1", "gene_name": "Nomo1", "organism": "Mouse", "refseq_name": "BOS complex subunit NOMO1 precursor", "refseq_ac": [ { "id": "NP_694697", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694697", "type": "external" } ], "gene_names_uniprotkb": "Nomo1", "gene_names_refseq": "D7Ertd156e; Nomo1; Nomo; pM5", "protein_names_uniprotkb": "BOS complex subunit NOMO1; Nodal modulator 1", "protein_names_refseq": "BOS complex subunit NOMO1 precursor; BOS complex subunit NOMO1", "tax_id": 10090, "disease": "", "pathway": " (mmu:211548)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;17242355;18299400;20484733;21952136;22872234;25428506;25576386;30084848;30779550;30899004;31219806;33649389;34203471;34428180;37507081;40997131", "class_list": "", "function": "Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions., [UniProtKB, UniProtKB]; NOMO1 gene knockdown inhibits the differentiation of P19 cells into cardiomyocytes, which highlights a potential role for NOMO1 in early cardiogenesis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 9, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q3TKZ1;Q8BJM1;Q8BJM8;Q8BLS9;Q8K074;Q8R1I7", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0043022 ribosome binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0032991 protein-containing complex;GO:0160064 multi-pass translocon complex", "go_biological_process": "GO:0160063 multi-pass transmembrane protein insertion into ER membrane", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "Q6GQT9-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BH74-1", "uniprot_id": [ { "id": "NU107_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BH74", "type": "external" } ], "mass": 106717.0, "length": 926, "protein_name": "Nuclear pore complex protein Nup107", "gene_name": "Nup107", "organism": "Mouse", "refseq_name": "nuclear pore complex protein Nup107 isoform 1", "refseq_ac": [ { "id": "NP_598771", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598771", "type": "external" } ], "gene_names_uniprotkb": "Nup107", "gene_names_refseq": "Nup107", "protein_names_uniprotkb": "Nuclear pore complex protein Nup107; 107 kDa nucleoporin; Nucleoporin Nup107", "protein_names_refseq": "107 kDa nucleoporin; nuclear pore complex protein Nup107 isoform 1; nuclear pore complex protein Nup107; nucleoporin Nup107", "tax_id": 10090, "disease": "nephrotic syndrome type 11 (Disease Ontology:DOID:0080385); ovarian dysgenesis 6 (Disease Ontology:DOID:0080498); Galloway-Mowat syndrome (Disease Ontology:DOID:0080694); 46 XX gonadal dysgenesis (Disease Ontology:DOID:14450)", "pathway": " (mmu:103468); (R-MMU-141430); (R-MMU-141444); (R-MMU-159227); (R-MMU-159230); (R-MMU-159231); (R-MMU-159236); (R-MMU-170822); (R-MMU-1855170); (R-MMU-1855196); (R-MMU-1855229); (R-MMU-191859); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-3108214); (R-MMU-3232142); (R-MMU-3301854); (R-MMU-3371453); (R-MMU-4085377); (R-MMU-4551638); (R-MMU-4570464); (R-MMU-4615885); (R-MMU-5663220); (R-MMU-68877); (R-MMU-9615933); (R-MMU-9648025)", "pathway_count": 26, "publication_count": 9, "publication_id_list": "21183079;21750661;24129315;26495903;30022050;31219806;33300544;34887587;39627609", "class_list": "", "function": "Functions as a component of the nuclear pore complex (NPC)., [UniProtKB, UniProtKB]; Nucleoporins 107, 62 and 153 mediate Kcnq1ot1 imprinted domain regulation in extraembryonic endoderm stem cells. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Required for the assembly of peripheral proteins into the NPC. May anchor NUP62 to the NPC. Involved in nephrogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q99KH5", "ec_number_list": [], "go_molecular_function": "GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0031080 nuclear pore outer ring;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0031965 nuclear membrane;GO:0000776 kinetochore", "go_biological_process": "GO:0072006 nephron development;GO:0006406 mRNA export from nucleus;GO:0006913 nucleocytoplasmic transport;GO:0008585 female gonad development;GO:0051292 nuclear pore complex assembly", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8BH74-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91ZA8-1", "uniprot_id": [ { "id": "NRARP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91ZA8", "type": "external" } ], "mass": 12492.0, "length": 114, "protein_name": "Notch-regulated ankyrin repeat-containing protein", "gene_name": "Nrarp", "organism": "Mouse", "refseq_name": "notch-regulated ankyrin repeat-containing protein", "refseq_ac": [ { "id": "NP_080256", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080256", "type": "external" } ], "gene_names_uniprotkb": "Nrarp", "gene_names_refseq": "2700054M22Rik; Nrarp", "protein_names_uniprotkb": "Notch-regulated ankyrin repeat-containing protein", "protein_names_refseq": "notch-regulated ankyrin repeat-containing protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:67122)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11744373;11783997;12794108;19154719;19268448;21795391;21998026;24015274", "class_list": "", "function": "Different effects of Nrarp overexpression suggest that alternate Notch signaling pathways mediate T- versus B-cell lineage commitment and thymocyte maturation., [RefSeq, PubMed]; Downstream effector of Notch signaling. Involved in the regulation of liver cancer cells self-renewal (By similarity). Involved in the regulation of canonical Wnt signaling by stabilizing LEF1 (By similarity). Involved in angiogenesis acting downstream of Notch at branch points to regulate vascular density. Proposed to integrate endothelial Notch and Wnt signaling to control stalk cell proliferation and to stablilize new endothelial connections during angiogenesis (PubMed:19154719). During somitogenesis involved in maintenance of proper somite segmentation and proper numbers of somites and vertebrae. Required for proper anterior-posterior somite patterning. Proposed to function in a negative feedback loop to destabilize Notch 1 intracellular domain (NICD) and down-regulate the Notch signal, preventing expansion of the Notch signal into the anterior somite domain (PubMed:21795391, PubMed:21998026)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Please add ref to Xenopus: 2002 Mechanisms of Development 110, 113-124. Where they call it 'Xnap', [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80UV7;Q9CZM1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007219 Notch signaling pathway;GO:0022407 regulation of cell-cell adhesion;GO:0001938 positive regulation of endothelial cell proliferation;GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q91ZA8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99K48-1", "uniprot_id": [ { "id": "NONO_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99K48", "type": "external" } ], "mass": 54541.0, "length": 473, "protein_name": "Non-POU domain-containing octamer-binding protein", "gene_name": "Nono", "organism": "Mouse", "refseq_name": "non-POU domain-containing octamer-binding protein isoform a", "refseq_ac": [ { "id": "NP_001239447", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239447", "type": "external" } ], "gene_names_uniprotkb": "Nono", "gene_names_refseq": "NRB54; Nono; P54NRB; nonA", "protein_names_uniprotkb": "Non-POU domain-containing octamer-binding protein; NonO protein", "protein_names_refseq": "non-POU domain-containing octamer-binding protein isoform a", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); syndromic X-linked intellectual disability 34 (Disease Ontology:DOID:0060817); aortic dissection (Disease Ontology:DOID:0080685); intellectual disability (Disease Ontology:DOID:1059); atherosclerosis (Disease Ontology:DOID:1936); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (mmu:53610)", "pathway_count": 1, "publication_count": 29, "publication_id_list": "12522145;15140795;15860628;19144319;21183079;21750661;22645316;22966205;23806337;24788674;25153642;25605945;26571461;28135057;28528544;32286661;33300544;33725478;34428180;34678516;34887587;36852467;37453647;38417578;38964745;40885482;8355702;8626664;9001221", "class_list": "", "function": "An N-terminal and ankyrin repeat domain interactome of Shank3 identifies the protein complex with the splicing regulator Nono in mice., [RefSeq, PubMed]; DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double-stranded DNA (PubMed:8355702). Also binds single-stranded DNA and RNA at a site independent of the duplex site (By similarity). Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ (By similarity). Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b (By similarity). Together with PSPC1, required for the formation of nuclear paraspeckles (By similarity). The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs (By similarity). The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1 (By similarity). The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends (By similarity). In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex (By similarity). NONO is involved in transcriptional regulation (By similarity). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity (By similarity). NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription (PubMed:9001221). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (PubMed:22966205). Important for the functional organization of GABAergic synapses (PubMed:26571461). Plays a specific and important role in the regulation of synaptic RNAs and GPHN/gephyrin scaffold structure, through the regulation of GABRA2 transcript (PubMed:26571461). Plays a key role during neuronal differentiation by recruiting TET1 to genomic loci and thereby regulating 5-hydroxymethylcytosine levels (PubMed:32286661). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Paraspeckle protein NONO attenuates vascular calcification by inhibiting bone morphogenetic protein 2 transcription., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q63887;Q9CYQ4;Q9DBP2", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0042802 identical protein binding;GO:0106222 lncRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0016607 nuclear speck;GO:0001650 fibrillar center", "go_biological_process": "GO:1904385 cellular response to angiotensin;GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "Q99K48-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99P88-1", "uniprot_id": [ { "id": "NU155_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99P88", "type": "external" } ], "mass": 155118.0, "length": 1391, "protein_name": "Nuclear pore complex protein Nup155", "gene_name": "Nup155", "organism": "Mouse", "refseq_name": "nuclear pore complex protein Nup155", "refseq_ac": [ { "id": "NP_573490", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_573490", "type": "external" } ], "gene_names_uniprotkb": "Nup155", "gene_names_refseq": "D930027M19Rik; Nup155; mKIAA0791", "protein_names_uniprotkb": "Nuclear pore complex protein Nup155; 155 kDa nucleoporin; Nucleoporin Nup155", "protein_names_refseq": "155 kDa nucleoporin; nuclear pore complex protein Nup155; nucleoporin Nup155", "tax_id": 10090, "disease": "familial atrial fibrillation (Disease Ontology:DOID:0050650)", "pathway": " (mmu:170762); (R-MMU-159227); (R-MMU-159230); (R-MMU-159231); (R-MMU-159236); (R-MMU-170822); (R-MMU-1855170); (R-MMU-1855196); (R-MMU-1855229); (R-MMU-191859); (R-MMU-3108214); (R-MMU-3232142); (R-MMU-3301854); (R-MMU-3371453); (R-MMU-4085377); (R-MMU-4551638); (R-MMU-4570464); (R-MMU-4615885); (R-MMU-9615933)", "pathway_count": 19, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;19070573;21750661;22645316;23641069;24788674;28135057;28528544;29187734;29848314;31219806;34428180;34887587;35820727;36210013;37828378;39627609", "class_list": "", "function": "Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; NUP155 regulates cardioplasticity of a sub-network embedded within a larger framework of genome integrity, and exemplifies how transcriptome cardiogenicity in an embryonic stem cell genome is recalibrated by nucleoporin dysfunction Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0031965 nuclear membrane;GO:0044611 nuclear pore inner ring;GO:0005643 nuclear pore", "go_biological_process": "GO:0006406 mRNA export from nucleus;GO:0006913 nucleocytoplasmic transport;GO:0034504 protein localization to nucleus;GO:0035196 miRNA processing;GO:0086014 atrial cardiac muscle cell action potential", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q99P88-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61120-1", "uniprot_id": [ { "id": "SHC3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61120", "type": "external" } ], "mass": 52121.0, "length": 474, "protein_name": "SHC-transforming protein 3", "gene_name": "Shc3", "organism": "Mouse", "refseq_name": "SHC-transforming protein 3", "refseq_ac": [ { "id": "NP_033193", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033193", "type": "external" } ], "gene_names_uniprotkb": "Shc3; Nshc; ShcC", "gene_names_refseq": "N-Shc; Rai; Shc3; ShcC", "protein_names_uniprotkb": "SHC-transforming protein 3; N-Shc; Neuronal Shc; SH2 domain protein C3; SHC-transforming protein C; Src homology 2 domain-containing-transforming protein C3", "protein_names_refseq": "SH2 domain protein C3; SHC-transforming protein 3; SHC-transforming protein C; neuronal Shc", "tax_id": 10090, "disease": "", "pathway": " (mmu:20418); (R-MMU-167044); (R-MMU-5673001); (R-MMU-8853659)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "21183079;21750661;25428506;31134091;31944299;34360699;8610109", "class_list": "", "function": "Differential Proteomic Analysis of Astrocytes and Astrocytes-Derived Extracellular Vesicles from Control and Rai Knockout Mice: Insights into the Mechanisms of Neuroprotection. Publication Status: Online-Only, [RefSeq, PubMed]; Rai deficiency enhances the ability of astrocytes to upregulate the expression and activity of the ectonucleotidase CD39, which catalyzes the conversion of extracellular ATP to the immunosuppressive metabolite adenosine, through both contact-dependent and-independentmechanisms. Publication Status: Online-Only, [RefSeq, PubMed]; Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons (By similarity)., [UniProtKB]; The Shc protein Rai enhances T-cell survival under hypoxia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZAX2", "ec_number_list": [], "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0030971 receptor tyrosine kinase binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007611 learning or memory;GO:0035556 intracellular signal transduction;GO:0035249 synaptic transmission, glutamatergic", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q61120-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6V4S5-1", "uniprot_id": [ { "id": "SDK2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6V4S5", "type": "external" } ], "mass": 239902.0, "length": 2176, "protein_name": "Protein sidekick-2", "gene_name": "Sdk2", "organism": "Mouse", "refseq_name": "protein sidekick-2 precursor", "refseq_ac": [ { "id": "NP_766388", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766388", "type": "external" } ], "gene_names_uniprotkb": "Sdk2; Kiaa1514", "gene_names_refseq": "4632412F08Rik; 5330435L01Rik; Sdk-2; Sdk2; mKIAA1514", "protein_names_uniprotkb": "Protein sidekick-2", "protein_names_refseq": "protein sidekick-2 precursor; protein sidekick-2; sidekick 2; sidekick homolog 2", "tax_id": 10090, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:237979); (R-MMU-373756)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;15213259;15703275;20219992;21750661;25428506;26287463;30150416;30899004;31219806;33300544;34428180", "class_list": "", "function": "Adhesion molecule that promotes lamina-specific synaptic connections in the retina and is specifically required for the formation of neuronal circuits that detect motion (PubMed:26287463). Acts by promoting formation of synapses between two specific retinal cell types: the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. Formation of synapses between these two cells plays a key role in detection of motion (PubMed:26287463). Promotes synaptic connectivity via homophilic interactions (PubMed:26287463)., [UniProtKB, PubMed]; Results establish that the first and second immunoglobulin domains of sidekick-1 and -2 are necessary and sufficient to mediate and target homophilic adhesion, [RefSeq, PubMed]; The results suggest that the Ig-like domains and the fibronectin III (FnIII) domains of Sidekicks play different roles in cell adhesion. The Ig-like domains mediate the homophilic transinteractions bridging adjacent cells, while the FnIII domains interact with membranes, resulting in a tight adhesion interface between cells, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 16, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 17, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 17, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 18, "disease_count": 1, "glyco_site_count": 19, "binding_glycan_count": 0, "secondary_ac_list": "Q3TTK1;Q5U5W7;Q6ZPP2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse;GO:0016020 membrane", "go_biological_process": "GO:0007416 synapse assembly;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0010842 retina layer formation;GO:0060219 camera-type eye photoreceptor cell differentiation;GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 4.9, "record_id": "Q6V4S5-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1100000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q923E4-1", "uniprot_id": [ { "id": "SIR1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q923E4", "type": "external" } ], "mass": 80372.0, "length": 737, "protein_name": "NAD-dependent protein deacetylase sirtuin-1", "gene_name": "Sirt1", "organism": "Mouse", "refseq_name": "NAD-dependent protein deacetylase sirtuin-1 isoform 1", "refseq_ac": [ { "id": "NP_062786", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062786", "type": "external" } ], "gene_names_uniprotkb": "Sirt1; Sir2l1", "gene_names_refseq": "SIR2L1; Sir2alpha; Sir2a; Sir2; Sirt1", "protein_names_uniprotkb": "NAD-dependent protein deacetylase sirtuin-1; 2.3.1.-; 2.3.1.286; NAD-dependent protein deacylase sirtuin-1; Regulatory protein SIR2 homolog 1; SIR2-like protein 1; SIR2alpha; Sir2; mSIR2a", "protein_names_refseq": "NAD-dependent protein deacetylase sirtuin-1 isoform 1; NAD-dependent protein deacetylase sirtuin-1; NAD-dependent protein deacylase sirtuin-1; SIR2-like protein 1; regulatory protein SIR2 homolog 1; sirtuin 1 ((silent mating type information regulation 2, homolog) 1", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); osteoporosis (Disease Ontology:DOID:11476); nephrogenic diabetes insipidus (Disease Ontology:DOID:12387); Huntington's disease (Disease Ontology:DOID:12858); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); epilepsy (Disease Ontology:DOID:1826); impotence (Disease Ontology:DOID:1875); atherosclerosis (Disease Ontology:DOID:1936); acute kidney failure (Disease Ontology:DOID:3021); middle cerebral artery infarction (Disease Ontology:DOID:3525); macular degeneration (Disease Ontology:DOID:4448); myocardial infarction (Disease Ontology:DOID:5844); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); senile cataract (Disease Ontology:DOID:9669); obesity (Disease Ontology:DOID:9970); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (mmu:93759); (R-MMU-3371453); (R-MMU-9617629); (R-MMU-9856649)", "pathway_count": 4, "publication_count": 71, "publication_id_list": "10693811;11250901;11672522;12482959;12651913;12887892;12960381;15175761;15220471;15632193;15716268;15744310;15788402;16098828;16224023;16269335;16366736;16790548;16892051;17098745;17197703;17347648;17620057;17901049;17936707;18004385;18270565;18296641;18371449;18477450;18662546;18662547;18687325;18687677;19299583;19356714;19478080;19680552;20167603;20620997;20668652;20817729;20955178;20972425;20975832;21176092;21183079;21187328;21189328;21622680;21750661;22195961;22510882;22645316;23142079;23160044;26910618;27470296;28364022;28533219;28842251;28883095;28923965;30026585;30193097;31219806;32152092;34428180;38300636;39627609;39695235", "class_list": "", "function": "Catalytically inactive 75SirT1 may be involved in regulation of apoptosis. May be involved in protecting chondrocytes from apoptotic death by associating with cytochrome C and interfering with apoptosome assembly., [UniProtKB, UniProtKB]; Deacetylates 'Lys-382' of p53/TP53, however with lower activity than isoform 1. In combination, the two isoforms exert an additive effect. Isoform 2 regulates p53/TP53 expression and cellular stress response and is in turn repressed by p53/TP53 presenting a SIRT1 isoform-dependent auto-regulatory loop., [UniProtKB, UniProtKB]; NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy (PubMed:11250901, PubMed:11672522, PubMed:12651913, PubMed:12887892, PubMed:12960381, PubMed:15175761, PubMed:15220471, PubMed:15632193, PubMed:15744310, PubMed:15788402, PubMed:16098828, PubMed:16366736, PubMed:16790548, PubMed:16892051, PubMed:17098745, PubMed:17347648, PubMed:17620057, PubMed:17901049, PubMed:17936707, PubMed:18004385, PubMed:18296641, PubMed:18371449, PubMed:18477450, PubMed:18662546, PubMed:18662547, PubMed:18687677, PubMed:19299583, PubMed:19356714, PubMed:20167603, PubMed:20817729, PubMed:21176092, PubMed:21187328, PubMed:21189328, PubMed:21622680, PubMed:23160044, PubMed:28883095). Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression (By similarity). Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively (By similarity). Serves as a sensor of the cytosolic ratio of NAD(+)/NADH which is altered by glucose deprivation and metabolic changes associated with caloric restriction (By similarity). Is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT) (PubMed:12887892, PubMed:18477450). Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes (By similarity). The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus (PubMed:18004385). Deacetylates 'Lys-266' of SUV39H1, leading to its activation (By similarity). Inhibits skeletal muscle differentiation by deacetylating PCAF and MYOD1 (PubMed:12887892). Deacetylates H2A and 'Lys-26' of H1-4 (By similarity). Deacetylates 'Lys-16' of histone H4 (in vitro) (By similarity). Involved in NR0B2/SHP corepression function through chromatin remodeling: Recruited to LRH1 target gene promoters by NR0B2/SHP thereby stimulating histone H3 and H4 deacetylation leading to transcriptional repression (By similarity). Proposed to contribute to genomic integrity via positive regulation of telomere length; however, reports on localization to pericentromeric heterochromatin are conflicting (PubMed:21187328). Proposed to play a role in constitutive heterochromatin (CH) formation and/or maintenance through regulation of the available pool of nuclear SUV39H1 (By similarity). Upon oxidative/metabolic stress decreases SUV39H1 degradation by inhibiting SUV39H1 polyubiquitination by MDM2 (By similarity). This increase in SUV39H1 levels enhances SUV39H1 turnover in CH, which in turn seems to accelerate renewal of the heterochromatin which correlates with greater genomic integrity during stress response (By similarity). Deacetylates 'Lys-382' of p53/TP53 and impairs its ability to induce transcription-dependent proapoptotic program and modulate cell senescence (PubMed:11672522, PubMed:12960381). Deacetylates TAF1B and thereby represses rDNA transcription by the RNA polymerase I (PubMed:11250901). Deacetylates MYC, promotes the association of MYC with MAX and decreases MYC stability leading to compromised transformational capability (By similarity). Deacetylates FOXO3 in response to oxidative stress thereby increasing its ability to induce cell cycle arrest and resistance to oxidative stress but inhibiting FOXO3-mediated induction of apoptosis transcriptional activity; also leading to FOXO3 ubiquitination and protesomal degradation (By similarity). Appears to have a similar effect on MLLT7/FOXO4 in regulation of transcriptional activity and apoptosis (By similarity). Deacetylates DNMT1; thereby impairs DNMT1 methyltransferase-independent transcription repressor activity, modulates DNMT1 cell cycle regulatory function and DNMT1-mediated gene silencing (By similarity). Deacetylates RELA/NF-kappa-B p65 thereby inhibiting its transactivating potential and augments apoptosis in response to TNF (By similarity). Deacetylates HIF1A, KAT5/TIP60, RB1 and HIC1 (PubMed:17620057). Deacetylates FOXO1, which increases its DNA binding ability and enhances its transcriptional activity leading to increased gluconeogenesis in liver (PubMed:15220471, PubMed:15788402). Inhibits E2F1 transcriptional activity and apoptotic function, possibly by deacetylation (PubMed:16892051). Involved in HES1- and HEY2-mediated transcriptional repression (By similarity). In cooperation with MYCN seems to be involved in transcriptional repression of DUSP6/MAPK3 leading to MYCN stabilization by phosphorylation at 'Ser-62' (By similarity). Deacetylates MEF2D (By similarity). Required for antagonist-mediated transcription suppression of AR-dependent genes which may be linked to local deacetylation of histone H3 (By similarity). Represses HNF1A-mediated transcription (PubMed:21176092). Required for the repression of ESRRG by CREBZF (By similarity). Deacetylates NR1H3 and NR1H2 and deacetylation of NR1H3 at 'Lys-434' positively regulates transcription of NR1H3:RXR target genes, promotes NR1H3 proteasomal degradation and results in cholesterol efflux; a promoter clearing mechanism after reach round of transcription is proposed (PubMed:17936707). Involved in lipid metabolism: deacetylates LPIN1, thereby inhibiting diacylglycerol synthesis (By similarity). Implicated in regulation of adipogenesis and fat mobilization in white adipocytes by repression of PPARG which probably involves association with NCOR1 and SMRT/NCOR2 (PubMed:15175761). Deacetylates p300/EP300 and PRMT1 (PubMed:15632193, PubMed:28883095). Deacetylates ACSS2 leading to its activation, and HMGCS1 deacetylation (PubMed:16790548). Involved in liver and muscle metabolism (By similarity). Through deacetylation and activation of PPARGC1A is required to activate fatty acid oxidation in skeletal muscle under low-glucose conditions and is involved in glucose homeostasis (PubMed:15716268, PubMed:15744310, PubMed:17347648, PubMed:23142079). Involved in regulation of PPARA and fatty acid beta-oxidation in liver (PubMed:19356714). Involved in positive regulation of insulin secretion in pancreatic beta cells in response to glucose; the function seems to imply transcriptional repression of UCP2 (PubMed:16098828, PubMed:16366736, PubMed:17901049). Proposed to deacetylate IRS2 thereby facilitating its insulin-induced tyrosine phosphorylation (PubMed:17901049). Deacetylates SREBF1 isoform SREBP-1C thereby decreasing its stability and transactivation in lipogenic gene expression (By similarity). Involved in DNA damage response by repressing genes which are involved in DNA repair, such as XPC and TP73, deacetylating XRCC6/Ku70, and facilitating recruitment of additional factors to sites of damaged DNA, such as SIRT1-deacetylated NBN can recruit ATM to initiate DNA repair and SIRT1-deacetylated XPA interacts with RPA2 (By similarity). Also involved in DNA repair of DNA double-strand breaks by homologous recombination and specifically single-strand annealing independently of XRCC6/Ku70 and NBN (By similarity). Promotes DNA double-strand breaks by mediating deacetylation of SIRT6 (By similarity). Transcriptional suppression of XPC probably involves an E2F4:RBL2 suppressor complex and protein kinase B (AKT) signaling (By similarity). Transcriptional suppression of TP73 probably involves E2F4 and PCAF (By similarity). Deacetylates WRN thereby regulating its helicase and exonuclease activities and regulates WRN nuclear translocation in response to DNA damage (By similarity). Deacetylates APEX1 at 'Lys-6' and 'Lys-7' and stimulates cellular AP endonuclease activity by promoting the association of APEX1 to XRCC1 (By similarity). Catalyzes deacetylation of ERCC4/XPF, thereby impairing interaction with ERCC1 and nucleotide excision repair (NER) (By similarity). Increases p53/TP53-mediated transcription-independent apoptosis by blocking nuclear translocation of cytoplasmic p53/TP53 and probably redirecting it to mitochondria (By similarity). Deacetylates XRCC6/Ku70 at 'Lys-537' and 'Lys-540' causing it to sequester BAX away from mitochondria thereby inhibiting stress-induced apoptosis (By similarity). Is involved in autophagy, presumably by deacetylating ATG5, ATG7 and MAP1LC3B/ATG8 (PubMed:18296641, PubMed:21189328). Deacetylates AKT1 which leads to enhanced binding of AKT1 and PDK1 to PIP3 and promotes their activation (By similarity). Acts as a regulator of AMPK activity in response to calorie restriction: deacetylates the ATP6V1E1 subunit of the V-ATPase complex following activation by TULP3, leading to (1) V-ATPase complex inhibition on lysosomes and (2) AMPK activation via the AXIN1-STK11/LKB1 axis (PubMed:39695235). Proposed to play role in regulation of STK11/LBK1-dependent AMPK signaling pathways implicated in cellular senescence which seems to involve the regulation of the acetylation status of STK11/LBK1 (PubMed:18687677). Can deacetylate STK11/LBK1 and thereby increase its activity, cytoplasmic localization and association with STRAD; however, the relevance of such activity in normal cells is unclear (By similarity). In endothelial cells is shown to inhibit STK11/LBK1 activity and to promote its degradation (By similarity). Deacetylates SMAD7 at 'Lys-64' and 'Lys-70' thereby promoting its degradation (PubMed:17098745). Deacetylates CIITA and augments its MHC class II transactivation and contributes to its stability (By similarity). Deacetylates MECOM/EVI1 (By similarity). Deacetylates PML at 'Lys-487' and this deacetylation promotes PML control of PER2 nuclear localization (By similarity). During the neurogenic transition, represses selective NOTCH1-target genes through histone deacetylation in a BCL6-dependent manner and leading to neuronal differentiation (By similarity). Regulates the circadian expression of several core clock genes, including BMAL1, RORC, PER2 and CRY1 and plays a critical role in maintaining a controlled rhythmicity in histone acetylation, thereby contributing to circadian chromatin remodeling (PubMed:18662546, PubMed:18662547, PubMed:19299583). Deacetylates BMAL1 and histones at the circadian gene promoters in order to facilitate repression by inhibitory components of the circadian oscillator (PubMed:18662546, PubMed:18662547, PubMed:19299583). Deacetylates PER2, facilitating its ubiquitination and degradation by the proteasome (PubMed:18662546). Protects cardiomyocytes against palmitate-induced apoptosis (PubMed:21622680). Deacetylates XBP1 isoform 2; deacetylation decreases protein stability of XBP1 isoform 2 and inhibits its transcriptional activity (By similarity). Deacetylates PCK1 and directs its activity toward phosphoenolpyruvate production promoting gluconeogenesis (PubMed:30193097). Involved in the CCAR2-mediated regulation of PCK1 and NR1D1 (By similarity). Deacetylates CTNB1 at 'Lys-49' (By similarity). In POMC (pro-opiomelanocortin) neurons, required for leptin-induced activation of PI3K signaling (PubMed:20620997). Deacetylates SOX9; promoting SOX9 nuclear localization and transactivation activity (PubMed:26910618). Involved in the regulation of centrosome duplication: Deacetylates CENATAC in G1 phase, allowing for SASS6 accumulation on the centrosome and subsequent procentriole assembly (By similarity). Deacetylates NDC80/HEC1 (By similarity). In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by mediating protein delactylation, depropionylation and decrotonylation (PubMed:30026585). Mediates depropionylation of Osterix (SP7) (PubMed:30026585). Catalyzes decrotonylation of histones; it however does not represent a major histone decrotonylase (By similarity). Mediates protein delactylation of TEAD1 and YAP1 (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Sirt1(Sir2alpha) deacetylates p53 and promotes survival, [RefSeq, PubMed]; This gene encodes a member of the sirtuin family of proteins, characterized by their deacetylase activity and proposed role in longevity. The encoded protein regulates gene expression in a wide range of cell and tissue types through its NAD+-dependent deacetylation of histones, transcription factors and transcriptional coactivators. Brain-specific overexpression of this gene has been shown to result in increased median lifespan. Viability of homozygous knockout mice for this gene varies with strain background. Homozygous knockout mice of strains that do not exhibit embryonic lethality are sterile and have a reduced lifespan. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 15, "reported_mutagensis": 21, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 21, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9QXG8", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.3.1.286", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.286", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" }, { "id": "3.9.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.-", "type": "external" } ], "go_molecular_function": "GO:1990254 keratin filament binding;GO:0046970 histone H4K16 deacetylase activity, NAD-dependent;GO:0003713 transcription coactivator activity;GO:0004857 enzyme inhibitor activity;GO:0008047 enzyme activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0010824 regulation of centrosome duplication;GO:1903427 negative regulation of reactive oxygen species biosynthetic process;GO:0070857 regulation of bile acid biosynthetic process;GO:0051315 attachment of mitotic spindle microtubules to kinetochore;GO:0090400 stress-induced premature senescence", "synthesized_glycan_count": 0, "hit_score": 7.4, "record_id": "Q923E4-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P69744-1", "uniprot_id": [ { "id": "TRPV5_MOUSE", "url": "https://www.uniprot.org/uniprot/P69744", "type": "external" } ], "mass": 82218.0, "length": 723, "protein_name": "Transient receptor potential cation channel subfamily V member 5", "gene_name": "Trpv5", "organism": "Mouse", "refseq_name": "transient receptor potential cation channel subfamily V member 5", "refseq_ac": [ { "id": "NP_001007573", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007573", "type": "external" } ], "gene_names_uniprotkb": "Trpv5", "gene_names_refseq": "CAT2; D630033B11; ECAC1; Trpv5", "protein_names_uniprotkb": "Transient receptor potential cation channel subfamily V member 5; CaT2; Calcium transport protein 2; ECaC1; Epithelial calcium channel 1; OTRPC3; Osm-9-like TRP channel 3; TrpV5", "protein_names_refseq": "OTRPC3; calcium transport protein 2; epithelial calcium channel 1; osm-9-like TRP channel 3; transient receptor potential cation channel subfamily V member 5", "tax_id": 10090, "disease": "pre-eclampsia (Disease Ontology:DOID:10591); gestational diabetes (Disease Ontology:DOID:11714)", "pathway": " (mmu:194352); (R-MMU-3295583)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "12077127;12574114;12660155;14679186;15123711;16380433;21183079;21750661;26747426;27102152;30916584", "class_list": "", "function": "Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine (PubMed:12077127, PubMed:14679186). Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules (PubMed:14679186). The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay (PubMed:12077127). Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; The key function of TRPV5 is in active Ca2+ reabsorption and it has an essential role in Ca2+ homeostasis, [RefSeq, PubMed]; This study found that TRPV5 and TRPV6 are involved in calcium transport in the placenta and bone, and therefore play a role in calcium homeostasis during embryonic and fetal development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 1, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q2TB50", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0005516 calmodulin binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0034704 calcium channel complex", "go_biological_process": "GO:0051289 protein homotetramerization;GO:0006816 calcium ion transport;GO:0006874 intracellular calcium ion homeostasis;GO:0035809 regulation of urine volume;GO:0070588 calcium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P69744-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000100000001.010.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22366-1", "uniprot_id": [ { "id": "MYD88_MOUSE", "url": "https://www.uniprot.org/uniprot/P22366", "type": "external" } ], "mass": 33753.0, "length": 296, "protein_name": "Myeloid differentiation primary response protein MyD88", "gene_name": "Myd88", "organism": "Mouse", "refseq_name": "myeloid differentiation primary response protein MyD88", "refseq_ac": [ { "id": "NP_034981", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034981", "type": "external" } ], "gene_names_uniprotkb": "Myd88", "gene_names_refseq": "Myd88", "protein_names_uniprotkb": "Myeloid differentiation primary response protein MyD88", "protein_names_refseq": "myeloid differentiation primary response protein 88; myeloid differentiation primary response protein MyD88", "tax_id": 10090, "disease": "diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); lymphoplasmacytic lymphoma (Disease Ontology:DOID:0060901); colorectal carcinoma (Disease Ontology:DOID:0080199); Coronavirus infectious disease (Disease Ontology:DOID:0080599); anogenital venereal wart (Disease Ontology:DOID:11168); testicular lymphoma (Disease Ontology:DOID:12253); lung cancer (Disease Ontology:DOID:1324); breast cancer (Disease Ontology:DOID:1612); hepatitis B (Disease Ontology:DOID:2043); colon adenocarcinoma (Disease Ontology:DOID:234); central nervous system lymphoma (Disease Ontology:DOID:3234); lung non-small cell carcinoma (Disease Ontology:DOID:3908); esophageal cancer (Disease Ontology:DOID:5041); primary immunodeficiency disease (Disease Ontology:DOID:612); hepatocellular carcinoma (Disease Ontology:DOID:684); monoclonal gammopathy of uncertain significance (Disease Ontology:DOID:7442); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:17874); (R-MMU-1257604); (R-MMU-1810476); (R-MMU-209543); (R-MMU-3134963); (R-MMU-6811558); (R-MMU-9020702)", "pathway_count": 7, "publication_count": 19, "publication_id_list": "11909531;16951688;17018642;17635956;18941239;20173027;21750661;21897371;21998396;22187460;2374694;29395066;30905847;31507457;34428180;9013863;9344657;9575168;9697844", "class_list": "", "function": "Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response (PubMed:9697844). Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:9575168, PubMed:9697844). Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway (PubMed:9697844). Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (PubMed:17018642). Upon TLR8 activation by GU-rich single-stranded RNA (GU-rich RNA) derived from viruses, induces IL1B release through NLRP3 inflammasome activation (By similarity). MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (PubMed:17635956, PubMed:21998396). Mediates leukocyte recruitment at the inflammatory site (PubMed:18941239)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Defective in its ability to induce IRAK phosphorylation and NF-kappa-B activation and can function as a negative regulator of activation by IL-1 or lipopolysaccharide (LPS)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35916", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0035591 signaling adaptor activity;GO:0035325 Toll-like receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0070498 interleukin-1-mediated signaling pathway;GO:0032747 positive regulation of interleukin-23 production;GO:0002283 neutrophil activation involved in immune response;GO:0032740 positive regulation of interleukin-17 production;GO:0006954 inflammatory response", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P22366-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q71FD5-1", "uniprot_id": [ { "id": "ZNRF2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q71FD5", "type": "external" } ], "mass": 23705.0, "length": 238, "protein_name": "E3 ubiquitin-protein ligase ZNRF2", "gene_name": "Znrf2", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase ZNRF2", "refseq_ac": [ { "id": "NP_954594", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_954594", "type": "external" } ], "gene_names_uniprotkb": "Znrf2", "gene_names_refseq": "1190002C14Rik; D6Ertd365e; Znrf2", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase ZNRF2; 2.3.2.27; RING-type E3 ubiquitin transferase ZNRF2; Zinc/RING finger protein 2", "protein_names_refseq": "E3 ubiquitin-protein ligase ZNRF2; RING-type E3 ubiquitin transferase ZNRF2; zinc finger/RING finger 2; zinc/RING finger protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:387524); (R-MMU-983168)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "14561866;17242355;19131326;19144319;21183079;21750661", "class_list": "", "function": "E3 ubiquitin-protein ligase that plays a role in the establishment and maintenance of neuronal transmission and plasticity. Ubiquitinates the Na(+)/K(+) ATPase alpha-1 subunit/ATP1A1 and thereby influences its endocytosis and/or degradation. Also acts as a positive regulator of mTORC1 activation by amino acids, which functions upstream of the V-ATPase and of Rag-GTPases. In turn, phosphorylation by mTOR leads to its inhibition via targeting to the cytosol allowing a self-regulating feedback mechanism., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0001650 fibrillar center", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0070936 protein K48-linked ubiquitination;GO:0030007 intracellular potassium ion homeostasis;GO:0160177 positive regulation of autophagosome-lysosome fusion", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q71FD5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K0L9-1", "uniprot_id": [ { "id": "ZBT20_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K0L9", "type": "external" } ], "mass": 81034.0, "length": 741, "protein_name": "Zinc finger and BTB domain-containing protein 20", "gene_name": "Zbtb20", "organism": "Mouse", "refseq_name": "zinc finger and BTB domain-containing protein 20 isoform L", "refseq_ac": [ { "id": "NP_001272734", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001272734", "type": "external" } ], "gene_names_uniprotkb": "Zbtb20; Zfp288", "gene_names_refseq": "1300017A20Rik; 7330412A13Rik; A930017C21Rik; D16Wsu73e; DPZF; HOF; J20; ODA-8S; Oda8; Tg(PDGFB-APPSwInd)20Lms; Zbtb20; Zfp288", "protein_names_uniprotkb": "Zinc finger and BTB domain-containing protein 20; BTB/POZ domain zinc finger factor HOF; Zinc finger protein 288", "protein_names_refseq": "APP Tg; BTB/POZ domain zinc finger factor HOF; PDGF-APPSwInd; PDGF-hAPP695,751,770V171F, KM670/671NL; POZ/zinc finger transcription factor ODA-8; zinc finger and BTB domain-containing protein 20 isoform L; zinc finger and BTB domain-containing protein 20; zinc finger protein 288", "tax_id": 10090, "disease": "", "pathway": " (mmu:56490)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "11744704;17242355;21183079;21750661;22645316;23213215;27446912;32782141;32848054;34428180;34678516;35822049;36852467;40021952;40885482;40997131", "class_list": "", "function": "May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses (By similarity). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (PubMed:27446912)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 13, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 13, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 13, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "A6X916;Q9DBD4;Q9QZ87", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0010629 negative regulation of gene expression;GO:0055088 lipid homeostasis;GO:0071333 cellular response to glucose stimulus", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "Q8K0L9-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R020-1", "uniprot_id": [ { "id": "ZRAB2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R020", "type": "external" } ], "mass": 37350.0, "length": 330, "protein_name": "Zinc finger Ran-binding domain-containing protein 2", "gene_name": "Zranb2", "organism": "Mouse", "refseq_name": "zinc finger Ran-binding domain-containing protein 2 isoform 1", "refseq_ac": [ { "id": "NP_059077", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059077", "type": "external" } ], "gene_names_uniprotkb": "Zranb2; Zfp265; Zis; Znf265", "gene_names_refseq": "Zfp265; Zis; Znf265; Zranb2", "protein_names_uniprotkb": "Zinc finger Ran-binding domain-containing protein 2; Zinc finger protein 265; Zinc finger, splicing", "protein_names_refseq": "zinc finger Ran-binding domain-containing protein 2 isoform 1; zinc finger Ran-binding domain-containing protein 2; zinc finger protein 265; zinc finger, splicing", "tax_id": 10090, "disease": "", "pathway": " (mmu:53861)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10773668;17242355;17805964;21183079;21750661;22021003;23806337;34428180", "class_list": "", "function": "Findings suggested that Zranb2 is a novel BMP suppressor that forms a complex with Smads in the nucleus., [RefSeq, PubMed]; Regulation of GluR-B and SMN2 pre-mRNA splicing by ZNF265 implies this newly identified SR protein may play important roles in maintaining normal neuronal function and SMA pathogenesis, [RefSeq, PubMed]; Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (By similarity). May interfere with constitutive 5'-splice site selection (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TI29;Q3TLF5;Q3TUB7;Q3UD16", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0001530 lipopolysaccharide binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005634 nucleus", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0006396 RNA processing", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9R020-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q811H0-1", "uniprot_id": [ { "id": "ZBT42_MOUSE", "url": "https://www.uniprot.org/uniprot/Q811H0", "type": "external" } ], "mass": 46717.0, "length": 420, "protein_name": "Zinc finger and BTB domain-containing protein 42", "gene_name": "Zbtb42", "organism": "Mouse", "refseq_name": "zinc finger and BTB domain-containing protein 42", "refseq_ac": [ { "id": "NP_001093930", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093930", "type": "external" } ], "gene_names_uniprotkb": "Zbtb42", "gene_names_refseq": "EG382639; Gm5188; Zbtb42; simiRP58", "protein_names_uniprotkb": "Zinc finger and BTB domain-containing protein 42; Protein simiRP58", "protein_names_refseq": "protein simiRP58; zinc finger and BTB domain-containing protein 42", "tax_id": 10090, "disease": "distal arthrogryposis (Disease Ontology:DOID:0050646); lethal congenital contracture syndrome (Disease Ontology:DOID:0060558)", "pathway": " (mmu:382639)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "18262495;21193930;21750661", "class_list": "", "function": "Data show that ZBTB42 protein is expressed in human skeletal muscle and a murine cell line C2C12 myotubes., [RefSeq, PubMed]; Transcriptional repressor. Specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007517 muscle organ development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q811H0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DAU9-1", "uniprot_id": [ { "id": "ZN654_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DAU9", "type": "external" } ], "mass": 126445.0, "length": 1112, "protein_name": "Zinc finger protein 654", "gene_name": "Zfp654; Znf654", "organism": "Mouse", "refseq_name": "zinc finger protein 654", "refseq_ac": [ { "id": "NP_001334174", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334174", "type": "external" } ], "gene_names_uniprotkb": "Zfp654; Znf654; Zfp654", "gene_names_refseq": "1600021C16Rik; 1810008K20Rik; 433036; Gm5488; Zfp654; Znf654", "protein_names_uniprotkb": "Zinc finger protein 654", "protein_names_refseq": "zinc finger protein 654", "tax_id": 10090, "disease": "", "pathway": " (mmu:72020)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17242355;21183079;21750661", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A140LI34;Q8K390", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9DAU9-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BG28-1", "uniprot_id": [ { "id": "B3GL2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BG28", "type": "external" } ], "mass": 57219.0, "length": 504, "protein_name": "UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2", "gene_name": "B3galnt2", "organism": "Mouse", "refseq_name": "UDP-GalNAc:beta-1, 3-N-acetylgalactosaminyltransferase 2", "refseq_ac": [ { "id": "NP_848755", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848755", "type": "external" } ], "gene_names_uniprotkb": "B3galnt2", "gene_names_refseq": "A930105D20Rik; B3galnt2; D230016N13Rik", "protein_names_uniprotkb": "UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2; 2.4.1.313; Beta-1,3-GalNAc-T2; Beta-1,3-N-acetylgalactosaminyltransferase II", "protein_names_refseq": "UDP-GalNAc:beta-1, 3-N-acetylgalactosaminyltransferase 2; beta-1,3-GalNAc-T2; beta-1,3-N-acetylgalactosaminyltransferase II", "tax_id": 10090, "disease": "congenital muscular dystrophy-dystroglycanopathy type A11 (Disease Ontology:DOID:0111230)", "pathway": " (mmu:97884); (R-MMU-8932505)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "14724282;21750661;25428506;30084848;31219806;34428180", "class_list": "glycogene;glycosyltransferase", "function": "Beta-1,3-N-acetylgalactosaminyltransferase that synthesizes a unique carbohydrate structure, GalNAc-beta-1-3GlcNAc, on N- and O-glycans. Has no galactose nor galactosaminyl transferase activity toward any acceptor substrate. Involved in alpha-dystroglycan (DAG1) glycosylation: acts coordinately with GTDC2/POMGnT2 to synthesize a GalNAc-beta3-GlcNAc-beta-terminus at the 4-position of protein O-mannose in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan, which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 28, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q5U4F9;Q8BXL0", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.313", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.313", "type": "external" } ], "go_molecular_function": "GO:0008194 UDP-glycosyltransferase activity;GO:0008376 acetylgalactosaminyltransferase activity;GO:0016758 hexosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006493 protein O-linked glycosylation;GO:0009101 glycoprotein biosynthetic process;GO:0019276 UDP-N-acetylgalactosamine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BG28-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.11000", "kg_view_protein": true } ]